CN101518584A - Traditional Chinese medicine for curing urinary system infection and preparation method thereof - Google Patents
Traditional Chinese medicine for curing urinary system infection and preparation method thereof Download PDFInfo
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- CN101518584A CN101518584A CN200910131685A CN200910131685A CN101518584A CN 101518584 A CN101518584 A CN 101518584A CN 200910131685 A CN200910131685 A CN 200910131685A CN 200910131685 A CN200910131685 A CN 200910131685A CN 101518584 A CN101518584 A CN 101518584A
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Abstract
The invention discloses a traditional Chinese medicine for curing urinary system infection and a preparation method thereof. The traditional Chinese medicine is prepared by extracting and condensing Chinese thorowax, shizandra, Polygonum aviculare, phellodendron, angelica dahurica, teasel roots, mistletoe, Semen Abutili and liquorice and adding suitable medical accessories, has the functions of fever reduction, stranguria treatment, urination promotion, pain relief, kidney tonifying, essence strengthening, and the like and is used for curing pyretic stranguria, hot and ardor urine and various diseases of the urinary system infection. The invention has the advantages of simple preparation process and controllable quality. The medicine is made from pure Chinese medicinal herb, has remarkable curative effect, treats both principal and secondary aspects of the diseases, has no untoward effect and toxic side effect and is convenient to take and carry.
Description
Technical field
The present invention relates to a kind of Chinese drugs agentia for the treatment of urinary system infection and preparation method thereof.Especially a kind of medicament of Chinese medicine being made multiple diseases such as being used for pyretic stranguria, hot urination burning pain and urinary system infection and preparation method thereof.
Background technology
Urinary system infection typically refers to by antibacterial and directly attacks the nonspecific infection that urinary tract causes, comprises pyelonephritis, cystitis and urethritis.Because of infection is difficult to the location, so can be referred to as urinary system infection or urinary tract infection.Chinese medicine thinks that this disease belongs to " gonorrhea " category more, and its morbidity is many because of " damp-heat in lower-JIAO ", and sick position is at bladder and kidney, and characteristic of disease is based on damp and hot, deficient, blood stasis.Tcm clinical practice thinks that urinary system infection is that penting up in the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels is disease owing to invade or damp-heat in middle-JIAO is made a bet in damp and hot.Pyretic stranguria causes irritative symptoms of bladder such as frequent micturition, urgent micturition, dysurea; Treatment is then with clearing away heat-damp and promoting diuresis, and it is treating stranguria to detoxify, and the medicine of the kidney tonifying of invigorating blood circulation is main.
At present, the clinical treatment medicine is divided into two big classes:
The first kind is chemical medicine class.As the penbritin class: ampicillin, amoxicillin etc., quinolones; As levofloxacin, Gatifloxacin.Cephamycin class: as ceftazidime, cefoperazone.Macrolide:, act on chlamydia, mycoplasma, responsive microbial gonorrhea, cervicitis, urinary system infection etc. as azithromycin, Roxithromycin etc.
Second class is a Chinese medicine class preparation.
At present commercially available relevant Chinese medicine preparation has: comprise FUFANG SHIWEI JIAONANG, and the Herba Lysimachiae capsule, the peaceful granule of urine sense drenches granule clearly, BAZHENG HEJI, the clear granule of pyretic stranguria, MINIAONING KELI, SANJIN PIAN etc.
Treatment for urinary system infection, chemical medicine class is often selected in doctor's medication, chemistry medicine antimicrbial power is strong, and instant effect is though may control symptom in a short time, but because pathogenic bacterium can produce drug resistance rapidly, make when urinary system infection shows effect once more, curative effect worse and worse, taking dose is more and more higher, not only be difficult to cure, and often produce various toxic and side effects.Can cause the fetus permanent deafness as streptomycin and gentamycin, adult's acoustic nerve is also had certain infringement.Du-6859a also can cause renal damage in addition.Chinese patent medicine is relatively safe, and toxic and side effects is little, is difficult for making pathogenic bacterium to produce drug resistance, and it is invalid or chemical sproof patient is arranged that those are taken chemical medicine repeatedly, and it is suitable using Chinese medicine.
Through looking into Chinese medicine by nine flavors such as Radix Bupleuri, Fructus Schisandrae Chinensis, Herba Polygoni Avicularis, Cortex Phellodendri, the Radix Angelicae Dahuricae, Radix Dipsaci, Herba Taxilli, Semen Abutili, Radix Glycyrrhizae, have effects such as clearing heat and freeing strangury, promoting urination and stopping pain, reinforcing kidney and strengthening resistance, be used for multiple diseases such as pyretic stranguria, hot urination burning pain and urinary system infection.Former side preparation technology adopts perfect square to merge decocting extraction or Fructus Schisandrae Chinensis, the Radix Angelicae Dahuricae is only put forward the method that liposoluble partly adds Radix Bupleuri, Herba Polygoni Avicularis, Cortex Phellodendri, Radix Dipsaci, Herba Taxilli, Semen Abutili, Radix Glycyrrhizae water extract.
Summary of the invention
The object of the invention is to provide a kind of new extraction preparation method and Chinese drugs agentia thereof that is used for the treatment of urinary system infection, shows that through the animal experiment drug effect the present invention is better than other.
It is characterized in that it being that raw material by following weight ratio is made: Radix Bupleuri 0.1-120 part, Fructus Schisandrae Chinensis 0.1-100 Fen, Herba Polygoni Avicularis 0.1-100 part, Cortex Phellodendri 0.1-120 part, Radix Angelicae Dahuricae 0.1-100 part, Radix Dipsaci 0.1-100 part, Herba Taxilli 0.1-100 part, Semen Abutili 0.1-120 part, Radix Glycyrrhizae 0.1-100 part, its preparation method is: earlier separately or the liposoluble part in the united extraction Radix Angelicae Dahuricae, Fructus Schisandrae Chinensis, the part after above-mentioned two flavors are extracted and other seven flavors separately or combination in any extract water-soluble part; Water-soluble part partly merged with liposoluble make Chinese medicine preparation.
The specific embodiment
Embodiment 1, with Radix Bupleuri 120g, Fructus Schisandrae Chinensis 100g, Herba Polygoni Avicularis 100g, Cortex Phellodendri 120g, Radix Angelicae Dahuricae 100g, Radix Dipsaci 100g, Herba Taxilli 100g, Semen Abutili 120g, Radix Glycyrrhizae 100g, more than nine flavors, (1) gets Fructus Schisandrae Chinensis, the Radix Angelicae Dahuricae, adopts the supercritical carbon dioxide extraction method effective component extracting; (2) get Cortex Phellodendri, add 10 times of water gagings, decoct 3 times, each 1.5h filters, merging filtrate, and being evaporated to relative density is the clear paste of 1.30 (80 ℃); (3) get all the other 6 herbal medicines, add Fructus Schisandrae Chinensis, the Radix Angelicae Dahuricae, decoct with water secondary through extracting, 2 hours for the first time, 1.5 hours for the second time, collecting decoction, leave standstill, precipitate 24 hours, filter, filtrate is concentrated into the clear paste that relative density is about 1.1-1.3 (80 ℃), and 1 part of qinghuo reagent is with 4 parts of sucrose, 1 part in dextrin is made granule, drying, sieve, make 100 bags, promptly.
Character is: this product is brown xanchromatic granule; Sweet and sour, little hardship.
Usage and consumption: boiled water is taken after mixing it with water, one time 1 bag, 3 times on the one, children's is cut down according to the circumstance.
Embodiment 2, Radix Bupleuri 120g, Fructus Schisandrae Chinensis 100g, Herba Polygoni Avicularis 100g, Cortex Phellodendri 120g, Radix Angelicae Dahuricae 100g, Radix Dipsaci 100g, Herba Taxilli 100g, Semen Abutili 120g, Radix Glycyrrhizae 100g, more than nine the flavor, (1) gets Fructus Schisandrae Chinensis, add 10 times of amount 60% ethanol, reflux, extract, 2 times, each 1.5h.Merge ethanol extract, decompression recycling ethanol is condensed into thick paste, and is standby; (2) get the Radix Angelicae Dahuricae, add 10 times of amount 40% ethanol, reflux, extract, 2 times, each 2.5h.Merge ethanol extract, decompression recycling ethanol is condensed into thick paste, and is standby; (3) get Cortex Phellodendri, add 10 times of water gagings, decoct 3 times, each 1.5h filters, merging filtrate, and being evaporated to relative density is the clear paste of 1.30 (80 ℃); (4) get Radix Bupleuri, Herba Polygoni Avicularis, Radix Dipsaci, Herba Taxilli, Semen Abutili, Radix Glycyrrhizae mixing, add Fructus Schisandrae Chinensis, the Radix Angelicae Dahuricae through extracting, add 10 times of water gagings, decoct 2 times, 2 hours for the first time, 1.5 hours for the second time, collecting decoction, staticly settled 24 hours, and filtered, filtrate is concentrated into the clear paste that relative density is about 1.3 (80 ℃); (5) get above-mentioned every 1 part of clear paste that mixes down, add medicinal right amount of auxiliary materials, make granule, drying is sieved, and packing is made 100 bags, promptly.
Character is: this product is brown xanchromatic granule; Sweet and sour, little hardship.
Usage and consumption: boiled water is taken after mixing it with water, one time 1 bag, 3 times on the one, children's is cut down according to the circumstance.
Embodiment 3, Radix Bupleuri 120g, Fructus Schisandrae Chinensis 100g, Herba Polygoni Avicularis 100g, Cortex Phellodendri 120g, Radix Angelicae Dahuricae 100g, Radix Dipsaci 100g, Herba Taxilli 100g, Semen Abutili 120g, Radix Glycyrrhizae 100g, more than nine the flavor, (1) gets Fructus Schisandrae Chinensis, add 10 times of amount 50% ethanol, soak and adopt percolation to extract after 24 hours, merge ethanol extract, decompression recycling ethanol is condensed into thick paste, and is standby; (2) get the Radix Angelicae Dahuricae, add 10 times of amount 40% ethanol, soak and adopt percolation to extract after 24 hours.Merge ethanol extract, decompression recycling ethanol is condensed into thick paste, and is standby; (3) get Cortex Phellodendri, add 10 times of water gagings, decoct 3 times, each 2h filters, merging filtrate, and being evaporated to relative density is the clear paste of 1.30 (80 ℃); (4) get Radix Bupleuri, Herba Polygoni Avicularis, Radix Dipsaci, Herba Taxilli, Semen Abutili, Radix Glycyrrhizae mixing, add Fructus Schisandrae Chinensis, the Radix Angelicae Dahuricae through extracting, add 10 times of water gagings, decoct 2 times, 2 hours for the first time, 1.5 hours for the second time, collecting decoction, staticly settled 24 hours, and filtered, filtrate is concentrated into the clear paste that relative density is about 1.3 (80 ℃); (5) get above-mentioned every 1 part of clear paste that mixes down, add medicinal right amount of auxiliary materials, make granule, drying is sieved, and packing is made 100 bags, promptly.
Character is: this product is brown xanchromatic granule; Sweet and sour, little hardship.
Usage and consumption: boiled water is taken after mixing it with water, one time 1 bag, 3 times on the one, children's is cut down according to the circumstance.
Claims (3)
1, a kind of Chinese medicine preparation for the treatment of urinary system infection, and the preparation method of Chinese drugs agentia; It is characterized in that the Chinese medicine preparation that it is made up of following materials of weight proportions: Radix Bupleuri 0.1-120 part, Fructus Schisandrae Chinensis 0.1-100 Fen, Herba Polygoni Avicularis 0.1-100 part, Cortex Phellodendri 0.1-120 part, Radix Angelicae Dahuricae 0.1-100 part, Radix Dipsaci 0.1-100 part, Herba Taxilli 0.1-100 part, Semen Abutili 0.1-120 part, Radix Glycyrrhizae 0.1-100 part; Its preparation method is: earlier separately or the liposoluble part in the united extraction Radix Angelicae Dahuricae, Fructus Schisandrae Chinensis, the part after above-mentioned two flavors are extracted and other seven flavors separately or combination in any extract water-soluble part; Water-soluble part partly merged with liposoluble make Chinese medicine preparation.
2, extracting the solvent that uses in the liposoluble part method in the Radix Angelicae Dahuricae, the Fructus Schisandrae Chinensis according to claim 1 can be water, ethanol, ether, ethyl acetate, petroleum ether, hexane, butanols, dichloromethane, chloroform, benzene, carbon dioxide, acetone, carbon tetrachloride.
3, the Chinese medicine preparation for the treatment of urinary system infection according to claim 1 can be the dosage form described in the pharmaceutics, can be; Tablet, capsule, suspensoid, soft capsule, granule, oral liquid, unguentum, pill, injection, suppository, aerosol, spray and powder spray, fluid extract, extractum, powder, drop pill, mixture, syrup, transfusion.
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103007232A (en) * | 2012-12-27 | 2013-04-03 | 陈为兵 | Medicine for treating infantile urinary tract infection |
CN104189199A (en) * | 2014-09-25 | 2014-12-10 | 合肥平光制药有限公司 | Pharmaceutical composition for treating urinary tract infection, and preparation method |
CN112057519A (en) * | 2020-10-19 | 2020-12-11 | 中南大学湘雅医院 | Preparation method of medicament for treating urinary system infection |
-
2009
- 2009-04-15 CN CN200910131685A patent/CN101518584A/en active Pending
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103007232A (en) * | 2012-12-27 | 2013-04-03 | 陈为兵 | Medicine for treating infantile urinary tract infection |
CN103007232B (en) * | 2012-12-27 | 2014-07-30 | 陈为兵 | Medicine for treating infantile urinary tract infection |
CN104189199A (en) * | 2014-09-25 | 2014-12-10 | 合肥平光制药有限公司 | Pharmaceutical composition for treating urinary tract infection, and preparation method |
CN112057519A (en) * | 2020-10-19 | 2020-12-11 | 中南大学湘雅医院 | Preparation method of medicament for treating urinary system infection |
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Application publication date: 20090902 |