CN102370776A - Chinese medicinal compound preparation for treating prostatitis and preparation method thereof - Google Patents
Chinese medicinal compound preparation for treating prostatitis and preparation method thereof Download PDFInfo
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Abstract
The invention relates to Chinese medicinal compound preparation for treating prostatitis. The Chinese medicinal compound preparation comprises the following Chinese medicinal raw materials by weight: 13-17 grams of red-rooted salvia root, 8-12 grams of dahurian patrinia herb, 13-17 grams of wild chrysanthemum, 13-17 grams of spreading hedyotis herb, 8-12 grams of safflower, 8-12 grams of peach kernel, 8-12 grams of red paeony root, 8-12 grams of Chinese angelica, 5-7 grams of lightyellow sophora root and 8-12 grams of amur corktree bark. A preparation method of the Chinese medicinal compound preparation comprises the following steps of: cleaning the ten types of medicinal materials; mixing proportionally; adding water in an amount which is 5-7 times the total weight of the medicinal materials or 75 percent by volume of ethanol for decocting twice, every time for 80 minutes; combining decoction solutions obtained in two times; filtering; and concentrating to obtain a liquid extract of which the specific weight is 1.09 at 60 DEG C. The Chinese medicinal compound preparation can be prepared into any pharmaceutical dosage form, such as tablets, capsules, granules, oral liquid, pills and syrup with the conventional preparation process. The Chinese medicinal compound preparation prepared with the method has a remarkable curative effect, has a better effect than the conventional Western medicament therapy method for prostatitis, does not have any untoward reaction, and is worth popularizing on a large scale.
Description
Technical field
The present invention relates to prostatitic compound Chinese medicinal preparation of a kind of treatment and preparation method thereof, belong to field of traditional Chinese.
Background technology
Prostatitis is meant the acute and chronic inflammation due to prostate specific and the non-special infection, thus whole body that causes or local symptom.Prostatitis is one of commonly encountered diseases of young and middle-aged male, can be divided into acute and chronic two kinds.Acute prostatitis is by the body of prostate due to antibacterial or its toxin and the acute inflammation of glandular tube; Chronic prostatitis can be secondary to acute prostatitis or chronic posterior urethritis, also can be secondary to the infection at other positions of whole body.
Western medicine prostatitis curative effect is unstable at present, and side effect is more; And the treatment by Chinese herbs prostatitis not only can reach the purpose of treating both the principal and secondary aspects of a disease, has more reduced the side effect of prostatitis treating medication to patient body.
Summary of the invention
The object of the present invention is to provide prostatitic Chinese traditional compound medicine of a kind of treatment and preparation method thereof.
The present invention provides the compound Chinese medicinal preparation of a kind of Radix Salviae Miltiorrhizae, Herba Patriniae, Flos Chrysanthemi Indici, Herba Hedyotidis Diffusae, Flos Carthami, Semen Persicae, Radix Paeoniae Rubra, Radix Angelicae Sinensis, Radix Sophorae Flavescentis, Cortex Phellodendri compatibility to be used to treat prostatitis, and is evident in efficacy, has no adverse reaction.
Technical scheme of the present invention is following:
The prostatitic Chinese traditional compound medicine of a kind of treatment comprises the following weight Chinese medicinal raw materials: Radix Salviae Miltiorrhizae 13-17, Herba Patriniae 8-12, Flos Chrysanthemi Indici 13-17, Herba Hedyotidis Diffusae 13-17, Flos Carthami 8-12, Semen Persicae 8-12, Radix Paeoniae Rubra 8-12, Radix Angelicae Sinensis 8-12, Radix Sophorae Flavescentis 5-7, Cortex Phellodendri 8-12.
Wherein method for preparing is that above-mentioned 10 flavor medical materials are cleaned, and proportional mixing, the 5-7 that adds medical material gross weight water or volume ratio doubly is that 75% ethanol decocts 2 times; Each 80 minutes, merge 2 times decoction liquor, filter; And concentrate, proportion is 1.09 fluid extract when obtaining 60 ℃, adopts conventional preparation technology; Chinese medicine preparation of the present invention can be made into said dosage form on any pharmaceutics, like tablet, capsule, granule, oral liquid, pill, syrup.
Radix Salviae Miltiorrhizae, Flos Carthami, Semen Persicae blood circulation promoting and blood stasis dispelling in the present invention's prescription, removing obstruction for relieving pain; The Herba Patriniae clearing away heat-damp and promoting diuresis; Herba Hedyotidis Diffusae, Flos Chrysanthemi Indici heat-clearing and toxic substances removing, medicinal powder for relieving pain knot, promoting urination to remove dampness; All medicine comprehensive functions, heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, removing obstruction for relieving pain are accelerated microcirculation, improve the chronic congestion process of muscle group at the bottom of the basin; The releasing inflammatory blocks, and unimpeded prostate glandular tube increases the permeability of medicine, helps drug osmotic and goes into prostate and play a role.So the Chinese traditional compound medicine that the present invention makes is evident in efficacy, has no adverse reaction.
Specific embodiment
Embodiment 1:
The prostatitic Chinese traditional compound medicine of a kind of treatment comprises the following weight Chinese medicinal raw materials: Radix Salviae Miltiorrhizae 13, Herba Patriniae 8, Flos Chrysanthemi Indici 13, Herba Hedyotidis Diffusae 13, Flos Carthami 8, Semen Persicae 8, Radix Paeoniae Rubra 8, Radix Angelicae Sinensis 8, Radix Sophorae Flavescentis 5, Cortex Phellodendri 8.
Wherein method for preparing is that above-mentioned 10 flavor medical materials are cleaned, proportional mixing, and 5 times the decocting that adds the medical material gross weight boils 2 times, and each 80 minutes, merge 2 times decoction liquor, to filter, and concentrate, proportion is 1.09 fluid extract when obtaining 60 ℃.
Embodiment 2:
The prostatitic Chinese traditional compound medicine of a kind of treatment comprises the following weight Chinese medicinal raw materials: Radix Salviae Miltiorrhizae 15, Herba Patriniae 10, Flos Chrysanthemi Indici 15, Herba Hedyotidis Diffusae 15, Flos Carthami 10, Semen Persicae 10, Radix Paeoniae Rubra 10, Radix Angelicae Sinensis 10, Radix Sophorae Flavescentis 6, Cortex Phellodendri 10.
All the other are with embodiment 1.
Embodiment 3:
The prostatitic Chinese traditional compound medicine of a kind of treatment comprises the following weight Chinese medicinal raw materials: Radix Salviae Miltiorrhizae 17, Herba Patriniae 12, Flos Chrysanthemi Indici 17, Herba Hedyotidis Diffusae 17, Flos Carthami 12, Semen Persicae 12, Radix Paeoniae Rubra 12, Radix Angelicae Sinensis 12, Radix Sophorae Flavescentis 7, Cortex Phellodendri 12.
Wherein method for preparing is that above-mentioned 10 flavor medical materials are cleaned, proportional mixing, and 5 times of volume ratios that add the medical material gross weight are that 75% ethanol decocts 2 times, each 80 minutes, merges 2 times decoction liquor, filter, and concentrated, proportion is 1.09 fluid extract when obtaining 60 ℃.
Embodiment 4:
The prostatitic Chinese traditional compound medicine of a kind of treatment, wherein method for preparing is the medical material in the prescription to be cleaned proportional mixing; 6 times the volume ratio that adds the medical material gross weight is that 75% ethanol decocts 2 times; Each 80 minutes, merge 2 times decoction liquor, filter; And concentrate, proportion is 1.09 fluid extract when obtaining 60 ℃.
All the other are with embodiment 1.
Embodiment 5:
The prostatitic Chinese traditional compound medicine of a kind of treatment, wherein method for preparing is the medical material in the prescription to be cleaned proportional mixing; 6 times the decocting that adds the medical material gross weight boils 2 times, each 80 minutes, merges 2 times decoction liquor; Filter, and concentrate, proportion is 1.09 fluid extract when obtaining 60 ℃.
All the other are with embodiment 2.
Embodiment 6:
The prostatitic Chinese traditional compound medicine of a kind of treatment, wherein method for preparing is the medical material in the prescription to be cleaned proportional mixing; 6 times the decocting that adds the medical material gross weight boils 2 times, each 80 minutes, merges 2 times decoction liquor; Filter, and concentrate, proportion is 1.09 fluid extract when obtaining 60 ℃.
All the other are with embodiment 3.
Embodiment 7:
The prostatitic Chinese traditional compound medicine of a kind of treatment, wherein method for preparing is the medical material in the prescription to be cleaned proportional mixing; 7 times of volume ratios that add the medical material gross weight are that 75% ethanol decocts 2 times; Each 80 minutes, merge 2 times decoction liquor, filter; And concentrate, proportion is 1.09 fluid extract when obtaining 60 ℃.
All the other are with embodiment 2.
Embodiment 8:
The prostatitic Chinese traditional compound medicine of a kind of treatment comprises the following weight Chinese medicinal raw materials: Radix Salviae Miltiorrhizae 20, Herba Patriniae 15, Flos Chrysanthemi Indici 20, Herba Hedyotidis Diffusae 20, Flos Carthami 15, Semen Persicae 5, Radix Paeoniae Rubra 5, Radix Angelicae Sinensis 5, Radix Sophorae Flavescentis 2, Cortex Phellodendri 5.
Wherein method for preparing is that the medical material in the prescription is cleaned, proportional mixing, and 7 times the decocting that adds the medical material gross weight boils 2 times, and each 80 minutes, merge 2 times decoction liquor, to filter, and concentrate, proportion is 1.09 fluid extract when obtaining 60 ℃.
Embodiment 9:
The prostatitic Chinese traditional compound medicine of a kind of treatment comprises the following weight Chinese medicinal raw materials: Radix Salviae Miltiorrhizae 10, Herba Patriniae 5, Flos Chrysanthemi Indici 10, Herba Hedyotidis Diffusae 10, Flos Carthami 5, Semen Persicae 15, Radix Paeoniae Rubra 15, Radix Angelicae Sinensis 15, Radix Sophorae Flavescentis 10, Cortex Phellodendri 15.
Wherein method for preparing is that the medical material in the prescription is cleaned, proportional mixing, and 7 times of volume ratios that add the medical material gross weight are that 75% ethanol decocts 2 times, each 80 minutes, merges 2 times decoction liquor, filter, and concentrated, proportion is 1.09 fluid extract when obtaining 60 ℃.
Embodiment 10:
The prostatitic Chinese traditional compound medicine of a kind of treatment comprises the following weight Chinese medicinal raw materials: Radix Salviae Miltiorrhizae 12, Herba Patriniae 12, Flos Chrysanthemi Indici 12, Herba Hedyotidis Diffusae 18, Flos Carthami 7, Semen Persicae 13, Radix Paeoniae Rubra 7, Radix Angelicae Sinensis 12, Radix Sophorae Flavescentis 4, Cortex Phellodendri 12.
Wherein method for preparing is that above-mentioned 10 flavor medical materials are cleaned, proportional mixing, and 4 times the decocting that adds the medical material gross weight boils 2 times, and each 80 minutes, merge 2 times decoction liquor, to filter, and concentrate, proportion is 1.09 fluid extract when obtaining 60 ℃.
Embodiment 11:
According to " therapy of combining Chinese and Western medicine chronic prostatitis 132 examples " the disclosed prostate soup in " Liaoning University of TCM's journal " 2006,8 (5), comprise the raw material of Chinese medicine of following weight: Flos Carthami 10g; Herba Hedyotidis Diffusae 15g, Radix Salviae Miltiorrhizae 20g, Radix Paeoniae Rubra, each 15g of Rhizoma Chuanxiong; Semen Vaccariae 30g, Squama Manis lOg, Cortex Phellodendri, each 20g of Herba Lycopi; Semen Persicae, each 10g of Herba Lobeliae Chinensis, Herba Patriniae 30g, Radix Glycyrrhizae 6g.The damp and hot partially Flos Lonicerae 20g that adds, Herba Taraxaci 30g; The gas deficiency of YIN adds Radix Astragali 30g, Radix Angelicae Sinensis 15g, Cortex Lycii 1Og partially; Asthenia of both the spleen and kidney adds Radix Codonopsis 30g, Rhizoma Dioscoreae 15g, Herba Epimedii lOg partially; There is obvious distending pain symptom to add Rhizoma Corydalis 12g.The usefulness that is decocted in water for oral dose, every day potion.
Embodiment 12:
Be the prescription and the production technology of 02137976.9 the disclosed a kind of medicine granule for treating prostatitis of patent according to application number, comprise the raw material of Chinese medicine of following weight: Cortex Phellodendri 10g, Folium Pyrrosiae 20g, Herba Hedyotidis Diffusae 30g, Herba Patriniae 20g, Semen Coicis 20g, LIUYI SAN 20g, Semen Vaccariae 20g, Radix Salviae Miltiorrhizae 20g, Flos Carthami 10g, Radix Achyranthis Bidentatae 20g, Herba Leonuri 30g, Semen Plantaginis 20g.Various medicines are processed into lamellar remove slag after sieve is got through boiling, the decocting liquid after removing slag concentrates, and adds ethanol precipitation, filtered and recycled ethanol.Go solution behind the alcohol through being condensed into clear paste (clear paste proportion is 1.30-1.35), clear paste through detect qualified after with Icing Sugar, dextrin is processed granule (clear paste, Icing Sugar, dextrin ratio are 1:4:1); Dry once at 50 ℃ then; Granulate, by 15g * 10 wrap the specification requirement packing, the packing.One time one bag of taking after mixing it with water, twice on the one.
Embodiment 13: adopt conventional preparation technology, Chinese medicine preparation of the present invention can be made into said dosage form on any pharmaceutics, like tablet, capsule, granule, oral liquid, pill, syrup.
All the other are with embodiment 1-10.
Embodiment 14: the fluid extract of the mix homogeneously that will be made by embodiment 1-10 concentrates, and according to the operational approach of conventional tablet, adds pharmaceutic adjuvant; With each component mix homogeneously, wet granulation sieves; Adopt conventional tablet preparation method tabletting to process tablet, wherein each components contents is following:
Composition weight (part)
Mixed flow extractum 50
Starch 25
Microcrystalline Cellulose 12
Pulvis Talci 13
Polyethylene Glycol 10
All the other are with embodiment 1-10.
Embodiment 15: the fluid extract of the mix homogeneously that will be made by embodiment 1-10 concentrates, and according to the operational approach of conventional capsule, adds pharmaceutic adjuvant; With each component mix homogeneously; Granulate, adopt conventional capsule preparation method to fill and process capsule, wherein each components contents is following:
Composition weight (part)
Mixed flow extractum 100
Pregelatinized Starch 30
Lactis Anhydrous 20
Microcrystalline Cellulose 16
Calcium hydrogen phosphate 5
All the other are with embodiment 1-10.
Embodiment 16: the fluid extract of the mix homogeneously that will be made by embodiment 1-10 concentrates, according to the operational approach of conventional oral liquid, ethanol precipitation 1-2 time; Filter, concentrate aqueous precipitation; Filter, add pharmaceutic adjuvant, filter; The packing sterilization adopts conventional oral liquid preparation method to prepare oral liquid, and wherein each components contents is following:
Composition weight (part)
Mixed flow extractum 100
Ethanol 155
Sucrose 80
Sodium carboxymethyl cellulose 16
Oleum menthae 5
Sorbic acid 3
All the other are with embodiment 1-10.
The effectiveness study experiment:
Patient's data:
Totally 416 routine prostatitis patients, age 43-68 year, average 56.7 years old, course of disease 1-8, average 3.9 years; Be divided into 13 groups to 416 routine patients at random, every group 32 example, one group as matched group, organizes as treatment for 12 groups.
Therapeutic Method:
2 of matched group oral administered compound sulfamethoxazoles, 2 times/d, obey Tamsulosin 0.2 mg simultaneously, 1 time/d, the preceding clothes of sleeping; The Chinese medical concrete that embodiment 1-11 is made is 10 times of dilute with waters respectively by volume, take for respectively 11 groups of treatment groups,, each 100ml, 2 times/d, remaining two groups of treatment groups are taken the medicine that embodiment 11 and embodiment 12 make; Treatment group and matched group were all taken medicine 2 months continuously.
Criterion of therapeutical effect:
Recovery from illness: transference cure, EPS are checked continuous normal more than 2 times, and B is ultra, and inspection is normal.Produce effects: symptom disappears basically, EPS check continuous more than 2 times the more preceding minimizing 1/2 of WBC value or＜15/HP, B is ultra, and inspection makes moderate progress.Effectively: sx, EPS checks more preceding improvement.Invalid: symptom, sign and EPS inspection all do not have improvement or increase the weight of.
Table 1 is respectively organized clinical efficacy relatively
Drug eruption 1 example appears in matched group in therapeutic process, nausea and vomiting 2 examples; And any untoward reaction does not appear in the treatment group.
Can find out that from therapeutic effect efficacy result of the present invention obviously is superior to matched group, and be superior to the curative effect of the Chinese medicine medicine that similar prescription makes in the prior art, wherein best with the curative effect of embodiment 5, and do not have any untoward reaction; So the Chinese traditional compound medicine that the present invention makes is evident in efficacy, and effect is superior to existing prostatitic Therapeutic Method, has no adverse reaction, and is worth promoting on a large scale.
Claims (5)
1. the prostatitic Chinese traditional compound medicine of treatment comprises the following weight Chinese medicinal raw materials: Radix Salviae Miltiorrhizae 13-17, Herba Patriniae 8-12, Flos Chrysanthemi Indici 13-17.
2. the prostatitic Chinese traditional compound medicine of treatment comprises the following weight Chinese medicinal raw materials: Radix Salviae Miltiorrhizae 13-17, Herba Patriniae 8-12, Flos Chrysanthemi Indici 13-17, Herba Hedyotidis Diffusae 13-17, Flos Carthami 8-12, Semen Persicae 8-12, Radix Paeoniae Rubra 8-12, Radix Angelicae Sinensis 8-12, Radix Sophorae Flavescentis 5-7, Cortex Phellodendri 8-12.
3. the prostatitic Chinese traditional compound medicine of treatment comprises the following weight Chinese medicinal raw materials: Radix Salviae Miltiorrhizae 15, Herba Patriniae 10, Flos Chrysanthemi Indici 15, Herba Hedyotidis Diffusae 15, Flos Carthami 10, Semen Persicae 10, Radix Paeoniae Rubra 10, Radix Angelicae Sinensis 10, Radix Sophorae Flavescentis 6, Cortex Phellodendri 10.
4. like claim 2 or 3 said a kind of method for preparinies of treating prostatitic Chinese traditional compound medicine, it is characterized by: be that 10 flavor medical materials are cleaned proportional mixing; The 5-7 that adds medical material gross weight water or volume ratio doubly is that 75% ethanol decocts 2 times, each 80 minutes, merges 2 times decoction liquor; Filter; Concentrate, proportion is 1.09 fluid extract when obtaining 60 ℃, adopts conventional preparation technology; Can be made into said dosage form on any pharmaceutics, like tablet, capsule, granule, oral liquid, pill, syrup.
5. a kind of method for preparing of treating prostatitic Chinese traditional compound medicine as claimed in claim 4 is characterized by: be that above-mentioned 10 flavor medical materials are cleaned proportional mixing; 6 times the decocting that adds the medical material gross weight boils 2 times, each 80 minutes, merges 2 times decoction liquor; Filter, concentrate, proportion is 1.09 fluid extract when obtaining 60 ℃; Adopt conventional preparation technology, can be made into said dosage form on any pharmaceutics, like tablet, capsule, granule, oral liquid, pill, syrup.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104474349A (en) * | 2014-12-19 | 2015-04-01 | 黄根强 | Traditional Chinese medicine capsules for treating prostatitis and preparation method of traditional Chinese medicine capsules |
| CN105148135A (en) * | 2015-10-08 | 2015-12-16 | 温州医科大学附属第一医院 | Traditional Chinese medicine preparation for treating chronic prostatitis |
| CN105878540A (en) * | 2014-11-21 | 2016-08-24 | 朱丙臣 | Medicine for rapidly curing prostatitis, proctitis, impotence and premature ejaculation |
| CN107456386A (en) * | 2017-07-03 | 2017-12-12 | 上海长海医院 | The acupuncture needle of a kind of anti-inflammatory analgesic and can packing type field operation quick needle insertion device |
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| CN1102330A (en) * | 1993-11-04 | 1995-05-10 | 徐新宪 | Hip bath agent for prostatic diseases |
| CN1468622A (en) * | 2002-07-16 | 2004-01-21 | 卢国频 | Recipe and production process of medicine granule for treating prostatitis |
| CN1824205A (en) * | 2005-12-22 | 2006-08-30 | 于浩芬 | Medicine for treating chronic prostatitis and its preparation method |
| CN101020015A (en) * | 2006-02-15 | 2007-08-22 | 吴鹏 | Externally applied medicine for treating chronic prostatitis and prostatic hyperplasia |
| CN101152407A (en) * | 2007-10-17 | 2008-04-02 | 长春市三硕医药科技开发有限公司 | Medicament for treating chronic prostatitis and method of preparing the same |
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- 2011-11-17 CN CN2011103642694A patent/CN102370776A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1102330A (en) * | 1993-11-04 | 1995-05-10 | 徐新宪 | Hip bath agent for prostatic diseases |
| CN1468622A (en) * | 2002-07-16 | 2004-01-21 | 卢国频 | Recipe and production process of medicine granule for treating prostatitis |
| CN1824205A (en) * | 2005-12-22 | 2006-08-30 | 于浩芬 | Medicine for treating chronic prostatitis and its preparation method |
| CN101020015A (en) * | 2006-02-15 | 2007-08-22 | 吴鹏 | Externally applied medicine for treating chronic prostatitis and prostatic hyperplasia |
| CN101152407A (en) * | 2007-10-17 | 2008-04-02 | 长春市三硕医药科技开发有限公司 | Medicament for treating chronic prostatitis and method of preparing the same |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105878540A (en) * | 2014-11-21 | 2016-08-24 | 朱丙臣 | Medicine for rapidly curing prostatitis, proctitis, impotence and premature ejaculation |
| CN104474349A (en) * | 2014-12-19 | 2015-04-01 | 黄根强 | Traditional Chinese medicine capsules for treating prostatitis and preparation method of traditional Chinese medicine capsules |
| CN105148135A (en) * | 2015-10-08 | 2015-12-16 | 温州医科大学附属第一医院 | Traditional Chinese medicine preparation for treating chronic prostatitis |
| CN107456386A (en) * | 2017-07-03 | 2017-12-12 | 上海长海医院 | The acupuncture needle of a kind of anti-inflammatory analgesic and can packing type field operation quick needle insertion device |
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Application publication date: 20120314 |