CN104189199A - Pharmaceutical composition for treating urinary tract infection, and preparation method - Google Patents
Pharmaceutical composition for treating urinary tract infection, and preparation method Download PDFInfo
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Abstract
The invention discloses a pharmaceutical composition for treating urinary tract infection. The pharmaceutical composition comprises the following raw materials in parts by weight: 10-14 parts of amur corktree bark, 11-13 parts of radix bupleuri, 7-9 parts of scutellaria baicalensis, 9-11 parts of cortex acanthopanacis, 9-11 parts of shizandra berry, 9-11 parts of radix angelicae, 9-11 parts of desmodium, 9-11 parts of eucommia ulmoides, 11-13 parts of cluster mallow fruit and 9-11 parts of liquorice. The invention further discloses a preparation method for the pharmaceutical composition for treating the urinary tract infection. The pharmaceutical composition has the benefits that as a method of clearing away heat and detoxifying, and eliminating dampness and smoothing showering is adopted for urinary tract infection, the better curative effect is achieved, and the total effective rate is 98 percent.
Description
Technical field
The present invention relates to pharmaceutical composition technical field, relate in particular to a kind of pharmaceutical composition for the treatment of urinary tract infection and preparation method thereof.
Background technology
Urinary tract infection is to have a large amount of bacterial reproductions in urine, to cause urinary tract inflammation, and taking frequent micturition, urgent micturition, dysurea, urinary tract infection symptom etc. as clinical characters.Doctor trained in Western medicine medication is at present mainly antibiotic and antibiotic medicine, antiinflammatory is cured the symptoms, not the disease, and the side effect of antibiotic life-time service is larger, and part patient can produce drug resistance, antibiotic is again the medicine that country's restriction is used, and the Chinese medicine of therefore researching and developing a kind of safe and effective treatment urinary tract infection is significant.
Stranguria in the traditional Chinese medical science be by suffering from a deficiency of the kidney, damp-heat in the urinary bladder is mainly to cause bladder qi dysfunction, urethra is unfavorable, the not smooth class disease of urinating.The basic Clinical symptoms of stranguria is that frequent micturition is short puckery, and sound of rain pattering twinge is wanted not to the greatest extent, lower abdomen contracture, or bitterly draw waist abdomen, or with hematuria, or with turbid urine, or discharge sandstone etc.Therefore, urinary tract infection should be attributed to the category of traditional Chinese medical science stranguria.
The Etiological pathogenesis of urinary tract infection is generally following 6 points: 1, damp-heat in the urinary bladder: feel how unclean because of lower the moon in epigenesist, foul heresy is violated bladder from lower orifices, makes raw damp and hot; Or diseases caused by exogenous pathogenic factor are damp and hot, bet small intestinal, imports bladder into, is born in interior person, and how, because of the product of surfeit delicious food wine heat, transporting and transforming function of the spleen and stomach is not normal, long-pending humidogene heat, and damp and hot inflow bladder, disturbance in functioning of QI, disturbance in water passage, sends out then as stranguria; 2, dampness-heat in the liver and gallbladder: because feelings will is become estranged, angry impairing the liver, depression of liver-QI, gallbladder loses tonneau, stagnant heat in the liver and gall, Yu Huahuo for a long time, gas fire stagnation, in the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels, follows through bet bladder, and wine is raw damp and hot, sends out as primary disease; 3, three warmers are damp and hot: the friendship in autumn in summer, and damp and hot evil Sheng, invasion and attack body, the damp and hot tired resistance of heresy three warmers, disorder of QI movement, sends out as primary disease; Or damp and hot damaging the spleen and stomach, middle Jiao does not transport, disorder in ascending and descending, and turbid YIN failing to descend, the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels is unfavorable, damp and hot interior strongly fragrant, sends out as primary disease; 4, spleen deficiency of kidney-QI; With the passing of time stranguria, is crossed and is taken cold and coolly, and damaging the spleen and stomach is upset one's stomach, or overstrain, damage spleen soil, or damp-heat in the urinary bladder accumulates for a long time, internal injury, in kidney, causes spleen deficiency of kidney-QI, spleen is transporting not, kidney lose open entire, disturbance in water passage, turbid damp is reluctant to leave and is not gone, and drenches drop endlessly, time while doing only; 5, the hepatic and renal YIN deficiency: damp and hotly accumulate for a long time, or eliminating dampness by diuresis diuresis too, injures kidney yin; Deficiency of kidney yin, the kidney failing to nourish the liver, causes the hepatic and renal YIN deficiency.The deficiency of YIN and damp and hot being reluctant to leave, functioning of bladder is unfavorable, and dribbling urination is endlessly; Or hyperactivity of fire caused by deficiency of YIN, the asthenic fire network that burns, network blood trouble is overflow, and blood is with drowning; 6, deficiency of both QI and YIN: gonorrhea is controlled inadequate, though clear proof is gone, remaining heresy to the greatest extent, does not stop holding the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels, secretly consumes gas the moon; If clear profit is too, to go though damp and hot, healthy energy is injured; Or lose and control, obstinate disease, does not damp and hotly remove, impairment of both QI and YIN.Can show that from above the cause of disease of urinary tract infection is taking damp and hot as main, its pathological lesion has two large features: the one, damp and hotly run through the course of disease all the time; The 2nd, the damp and hot mechanism of qi that is jammed, hinders gasification.
Summary of the invention
The technical problem that basic background technology exists, the present invention proposes a kind of pharmaceutical composition for the treatment of urinary tract infection and preparation method thereof, for the damp-heat disease of urinary tract infection because of, adopt heat-clearing and toxic substances removing, method that dampness removing is treating stranguria, reached good therapeutic effect, total effective rate is 98%.
A kind of pharmaceutical composition for the treatment of urinary tract infection that the present invention proposes, its raw material comprises by weight: Cortex Phellodendri 10-14 part, Radix Bupleuri 11-13 part, Radix Scutellariae 7-9 part, Cortex Acanthopancis 9-11 part, Fructus Schisandrae Chinensis 9-11 part, Radix Angelicae Dahuricae 9-11 part, Herba Lysimachiae 9-11 part, Cortex Eucommiae 9-11 part, Fructus Malvae 11-13 part, Radix Glycyrrhizae 9-11 part.
Cortex Phellodendri, calls as Cortex Phellodendri, Cortex Phellodendri, bark of a cork tree wood, bark of a cork tree skin, is the dry bark of rutaceae wampee or Cortex Phellodendri, and the former practises title " Cortex Phellodendri ", and the latter practises title " Cortex Phellodendri ".Bitter in the mouth, cold in nature, return kidney, bladder, large intestine channel.There is heat clearing and damp drying, pathogenic fire purging except steaming, effect of detoxification sore treatment.Cure mainly hygropyretic dysentery, have loose bowels, jaundice; Nocturnal emission, stranguria with turbid discharge, leukorrhagia; Hectic fever due to YIN-deficiency consumptive fever; And aphtha of the mouth and tongue; Conjunctival congestion and swelling pain; Skin sore; Skin eczema.
Radix Bupleuri, begins to be loaded in Shennong's Herbal, classifies as top grade.Its another name for smoke, Asia puecon Hu, mountain dish, eat grass, faggot etc., be the dry root of umbelliferae bupleurum or Radix Bupeuri Scorzonerfolii..Bitter in the mouth, cold nature.Return liver, gallbladder meridian.There is reconciling superficies and interior, soothing the liver, the effect of yang invigorating.For cold, fever, alternate attack of chill and fever, distending pain in the chest and hypochondrium, menoxenia, uterine prolapse, proctoptosis.
The composition of Radix Bupleuri is mainly saikoside, sterol, volatile oil (bupleurumol, eugenol etc.), fatty oil (oleic acid, linoleic acid, Palmic acid, stearic acid etc.) and polysaccharide etc.In addition, still contain alkaloid, flavonoid, Rhizoma Kaempferiae glycosides, glucose, aminoacid etc.The pharmacological research demonstration of Radix Bupleuri, it has antipyretic, calmness, analgesia, antitussive, antibacterial, antiviral, antiinflammatory, the effects such as Promote immunity function; Wherein the effective ingredient of antiinflammatory is saponin, activate Pituitary Adrenal cortex system, many links that can act on inflammatory process as oozed out, capillary permeability, inflammatory mediator release, leukoplania, connective tissue proliferation etc., can all there is inhibitory action with desmoplastic inflammation to ankle joint due to multiple proinflammatory agent is swollen, and the effective ingredient of Promote immunity function is Bupleurum chinense polysaccharide, in reinforcement, engulf increased functionality, Natural killer activity, improve special viral antibody titre, improve lymphocyte and turn core rate, improve skin delayed hypersensitivity reaction.And Radix Bupleuri can kill or suppress Hemolytic streptococcus, staphylococcus aureus, vibrio cholera, tubercule bacillus, the pathogenic bacterias such as leptospira, from source treatment urinary tract infection.
Radix Scutellariae, calls as Radix Scutellariae, scutellaria tea, tsuchikane tea root etc., is the dry root of labiate Radix Scutellariae.Spring, Qiu Erji excavate, and remove fibrous root and silt, hit rough bark after solarization, dry.Bitter in the mouth, cold in nature, return lung, gallbladder, spleen, small intestinal, large intestine channel.There is heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive effect.Cure mainly high fever excessive thirst, cough due to lung-heat, damp-heat dysentery, jaundice, pyretic stranguria, tells, is defeated in battle, collapses, leaks, conjunctival congestion and swelling pain, frequent fetal movement, carbuncle furuncle.
Modern study proves, Radix Scutellariae is mainly containing baicalin, baicalin, wogonin, the compositions such as wogonoside, neobaicalein, cupreol.Its antimicrobial spectrum is wider, and does not develop immunity to drugs, and various bacteria, dermatophytes, leptospira etc. are had to inhibitory action.Even if the staphylococcus aureus that the antibiotic such as penicillin are developed immunity to drugs is still very sensitive to Radix Scutellariae.
Cortex Acanthopancis, have another name called Cortex Acanthopanacis Radicis, order bone, chase after that wind makes, CORTEX ACANTHOPANACIS etc., for Araliaceae machaka acanthopanax gracilistylus and the dry root bark of Acanthopanax sessiliflorus(Rupr.et Maxim.) Seem., main product in Hubei, the ground such as Henan, Anhui, Sichuan, wherein with Hubei produced it " CORTEX ACANTHOPANACIS " best in quality.Acrid in the mouth, hardship, warm in nature.Return liver, kidney channel.There is wind-damp dispelling; Invigorating the liver and kidney; Bone and muscle strengthening; The arteries and veins effect of invigorating blood circulation.For anemofrigid-damp arthralgia; Lumbocrural pain; Muscles and bones flaccidity is soft; Children's's walking retardation in children; Body void is frail; Traumatic injury; Fracture; Edema; Foot gas; Uncontrolled urination is itched.
Cortex Acanthopancis is carried out to pharmacological research discovery: Cortex Acanthopancis reaches antiphlogistic effects by reducing the release of inflammatory mediator and suppressing its proinflammatory effect; Cortex Acanthopancis total saponins and polysaccharide in Cortex Acanthopancis can improve body's immunity, and n-butanol extract and Cortex Acanthopancis ethanol extract in Cortex Acanthopancis all can improve the threshold of pain, has obvious analgesic activity.
Fructus Schisandrae Chinensis, is commonly called as Fructus Zanthoxyli Plansipini, sliding weight of steelyard, medicine Fructus Schisandrae Chinensis, face rattan, five Fructus Armeniacae Mumes etc., and " the sweet acid of five tastes skin and flesh, works hard in core, has saline taste " carried in Tang etc. " Newly Revised Canon of Materia Medica ", therefore there is the name of Fructus Schisandrae Chinensis.Ancient medical book Cheng Qi Wei Chi Zhu, profound and, meeting and, list in the earliest Sheng Nong's herbal classic top grade, herbal function is the power of strengthening by means of tonics, medical value is high.Fructus Schisandrae Chinensis is perennial fallen leaves liana, and plant can be for viewing and admiring.For magnoliaceae schisandra, practise and claim " Radix Schisandrae Bicoloris ".Sour in the mouth, sweet, warm in nature, return lung, the heart, kidney channel, there is convergence astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming function.For chronic cough dyspnea due to deficiency, emission, enuresis frequent micturition, incessant chronic diarrhea, spontaneous perspiration, night sweat, Tianjin wound is thirsty, the deficient pulse of losing heart, interior-heat is quenched one's thirst, palpitation and insomnia.
The Radix Angelicae Dahuricae, another name is Xue, the root of Dahurian angelica (" Songs of the South "), fragrance (" herbal classic "), membrane inside the rush stalk Li, Ze Fen (" WU Pu Bencao "), white Chai (" not Lu "), Radix Angelicae Dahuricae (Radix Heraclei Scabridi) (" smooth hard will ") is the root of samphire Yu Radix Angelicae Dahuricae, Xingan's Radix Angelicae Dahuricae, angelica anomala, Radix angelicae dahuricae or Yunnan cattle Radix Saposhnikoviae.Acrid in the mouth, warm in nature.Attach to the lung and stomach meridians.There is expelling wind and cold, understand things pain-stopping, detumescence and apocenosis, effect of dampness leukorrhagia stopping.For headache, toothache, nasal sinusitis, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, skin pruritus.
The Radix Angelicae Dahuricae be studies have shown that, main containing volatile oil, coumarin and derivant thereof (as angelicin, white Radix Angelicae Sinensis ether, Imperatoria ostruthium second element, angelicotoxin etc.) in the Radix Angelicae Dahuricae, in volatile oil, contain 3-methylene-6-cyclohexene, 11 charcoal alkene-4, elemene, hexadecanoic acid, nonenol etc., have the effects such as antiinflammatory, antipyretic-antalgic, spasmolytic, antibacterial, anticancer, radioprotective, it is effective that the illness such as hydrarthrosis, herpes zoster, psoriasis are controlled in the external of the clinical report Radix Angelicae Dahuricae.
Radix Glycyrrhizae, sweet in the mouth, property is flat, enters spleen, stomach, lung meridian.Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, clear throat, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
Herba Lysimachiae, calls as DIWUGONG, Drymoglossum subcordatum, Herba pteridis vittatae, Hydrocotyle vulgaris L., Lysimachia christinae Hance, Herba Dichodrae, gong, Huang, floor file lotus etc. everywhere, is the dry herb of Ofthe Primulaceae Lysimachia christinae Hance.Summer, Qiu Erji gather, and remove impurity, dry, and cutting is raw to be used.Sweet in the mouth, micro-hardship, cool in nature, return liver, gallbladder, kidney, urinary bladder channel.There is heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling, effect of dampness removing jaundice eliminating, can be used for pyretic stranguria, and Sha Lin urinates and puckeryly has a pain, jaundice dark coloured urine, carbuncle furuncle, venom, liver and bile stone, the diseases such as lithangiuria.Modern study shows, Herba Lysimachiae mainly, containing phenolic constituent and sterol, flavonoid, aminoacid, tannin, volatile oil, choline, potassium salt etc., has calculus, and antibacterial, antiinflammatory action, all has inhibitory action to humoral immunization, cellular immunization.
The Cortex Eucommiae, claims again to think celestial (" herbal classic "), Mian (" Bencao Tujing "), and Shi Sixian (" Amplification on Materia Medica addendum "), silk gross weight, silk neem bark (" Chinese medicinal herbal ") etc., be the bark of the Eucommiaceae plant Cortex Eucommiae.Sweet in the mouth, warm in nature, return Liver Channel, kidney channel.Energy invigorating the liver and kidney, bone and muscle strengthening, antiabortive.Cure mainly spinal column ache, foot and knee flaccidity, dribbling urination, uncontrolled urination is itched, and vaginal bleeding during pregnancy is wanted to fall, frequent fetal movement, hypertension.Pharmaceutical research to the Cortex Eucommiae shows, the extract of the Cortex Eucommiae or decoct have the effect of blood pressure lowering and diuresis.
Fructus Malvae, claims again Semen Abutili, is Mongols's conventional crude drugs, is the dry mature fruit of Malvaceae plant Semen Abutili.Summer, two season of autumn gather when fruit maturation, remove impurity, dry in the shade.Sweet in the mouth, puckery, cool in nature.There is clearing away heat and promoting diuresis, the function of detumescence.For urine retention, edema, thirsty; Urinary tract infection.
Preferably, the weight ratio of Radix Bupleuri, Radix Scutellariae, Cortex Acanthopancis, Fructus Schisandrae Chinensis, the Radix Angelicae Dahuricae and Herba Lysimachiae is 11.2-12.4:7.5-8.3:9.6-10.1:9.3-10.2:9.7-10.5:9.9-10.4.
Preferably, its raw material comprises by weight: Cortex Phellodendri 11-13 part, Radix Bupleuri 11.2-12.4 part, Radix Scutellariae 7.5-8.3 part, Cortex Acanthopancis 9.6-10.1 part, Fructus Schisandrae Chinensis 9.3-10.2 part, Radix Angelicae Dahuricae 9.7-10.5 part, Herba Lysimachiae 9.9-10.4 part, Cortex Eucommiae 9.5-10.3 part, Fructus Malvae 11.6-12.3 part, Radix Glycyrrhizae 9.4-10.4 part.
Preferably, its raw material comprises by weight: 12 parts of Cortex Phellodendris, 12 parts of Radix Bupleuri, 8 parts of Radix Scutellariaes, 10 parts of Cortex Acanthopanciss, 10 parts of Fructus Schisandrae Chinensis, 10 parts of the Radixs Angelicae Dahuricae, 10 parts, Radix Glycyrrhizae, 10 parts of Herba Lysimachiaes, 10 parts of the Cortexs Eucommiae, 12 parts of Fructus Malvae.
Preferably, its raw material also comprises adjuvant, adjuvant by steviosin and dextrin by weight forming for 1:121-125.
Adjuvant, refers in the time that preparation prescription designs, and adds the general designation of the medicinal material of all except principal agent in prescription for solving mouldability, effectiveness, stability, the safety of preparation.Its basic material and important component part that is pharmaceutical preparation, it is the material base that ensures pharmaceutical preparation prodution and development, in preparation formulation and production, play a part crucial, not only give medicine certain dosage form, and having very large relation with the curative effect, the reduction untoward reaction that improve medicine, its reliability and multiformity are the bases that ensures dosage form and preparation advance.
Steviosin is the main sweet substance in South America Paraguay and the common herbaceos perennial-Folium Stevlae Rebaudianae of Brazilian intersection leaf, and extract is crystalloid, also claims stevioside for sweetening agent.Refining steviosin is the crystallization of colorless and odorless, its sugariness is sucrose 300 times.Because heat is low, soluble in water or ethanol, also have a thermostability, be empty calory for sugar product, be diet or the conventional sugariness material of slimming food of diabetics.Steviosin has abundant medicinal and edibility, and safety simultaneously also obtains the detection certification of international professional institution in many ways.Present all International Controllers organize the safe edible product that all stevioside are considered as.These tissues comprise: Codex Alimentarius Commission (CAC), food additive joint specialist committee of Food and Agricultural Organization of the United Nations/World Health Organization (WHO) (JECFA), EFSA (EFSA), food and drug administration (FDA) and food standard management board of New Zealand (FSANZ).
Substituting saccharose, as correctives, makes patient take the fluctuation that can not produce blood glucose in process of the present invention in the present invention, thereby can not affect secretion and the effect of insulin in body, to expand use crowd, is conducive to the use of Patients With Abnormalities of Glucose Metabolism.
Preferably, its raw material also comprises adjuvant, adjuvant by steviosin and dextrin by weight forming for 1:123.
The preparation method of the pharmaceutical composition of a kind of above-mentioned treatment urinary tract infection that the present invention also proposes, using Cortex Phellodendri, Radix Bupleuri, Radix Scutellariae, Cortex Acanthopancis, Fructus Schisandrae Chinensis, the Radix Angelicae Dahuricae, Radix Glycyrrhizae, Herba Lysimachiae, the Cortex Eucommiae and Fructus Malvae as major ingredient, drop in extraction pot, decoct with water for the first time after 1.5-2.5h, add water for the second time and decoct again 1-2h and obtain decoction liquor twice, the water adding for the first time and the weight ratio of major ingredient are 7-9:1, and the water adding for the second time and the weight ratio of major ingredient are 5-7:1; After twice decoction liquor merged, filter and obtain filtering residue and filtrate; Filtrate is crossed after 95-105 mesh sieve, in the time of 88-92 DEG C, be concentrated into the extractum that relative density is 1.24-1.28; Extractum is crossed after atomization drying to 75-85 mesh sieve and obtained extract powder; Extract powder and adjuvant are mixed, granulate, are dried, sieve and are get final product.
Relative density in the present invention is that the density (being 1g/cm3) water in 4 DEG C is used as 1 and is used using water as with reference to density, is divided by and obtains with the density of water with the density of extractum.In actual production process, adopt gravimeter to measure the relative density of extractum.
Extractum is by suitable solvent extraction (or fried) active ingredient for medical material, concentrated, adjusts powdery or ointment preparation that concentration is made to required standard.
Preferably, using Cortex Phellodendri, Radix Bupleuri, Radix Scutellariae, Cortex Acanthopancis, Fructus Schisandrae Chinensis, the Radix Angelicae Dahuricae, Radix Glycyrrhizae, Herba Lysimachiae, the Cortex Eucommiae and Fructus Malvae as major ingredient, drop in extraction pot, decoct with water for the first time after 1.8-2.3h, add water for the second time and decoct again 1.4-1.6h and obtain decoction liquor twice, the water adding for the first time and the weight ratio of major ingredient are 7.8-8.3:1, and the water adding for the second time and the weight ratio of major ingredient are 5.5-6.4:1; After twice decoction liquor merged, filter and obtain filtering residue and filtrate; Filtrate is crossed after 93-102 mesh sieve, in the time of 89-91 DEG C, be concentrated into the extractum that relative density is 1.25-1.27; Extractum is crossed after atomization drying to 78-82 mesh sieve and obtained extract powder; Extract powder and adjuvant are mixed, granulate, are dried, sieve and are get final product.
Preferably, using Cortex Phellodendri, Radix Bupleuri, Radix Scutellariae, Cortex Acanthopancis, Fructus Schisandrae Chinensis, the Radix Angelicae Dahuricae, Radix Glycyrrhizae, Herba Lysimachiae, the Cortex Eucommiae and Fructus Malvae as major ingredient, drop in extraction pot, decoct with water for the first time after 2h, add water for the second time and decoct again 1.5h and obtain decoction liquor twice, the water adding for the first time and the weight ratio of major ingredient are 8:1, and the water adding for the second time and the weight ratio of major ingredient are 6:1; After twice decoction liquor merged, filter and obtain filtering residue and filtrate; Filtrate is crossed after 100 mesh sieves, in the time of 90 DEG C, be concentrated into relative density and be 1.26 extractum; Extractum is crossed after atomization drying to 80 mesh sieves and obtained extract powder; Extract powder and adjuvant are mixed, granulate, are dried, sieve and are get final product.
Cortex Phellodendri, Radix Bupleuri, Radix Scutellariae, Cortex Acanthopancis, Fructus Schisandrae Chinensis, the Radix Angelicae Dahuricae, Radix Glycyrrhizae, Herba Lysimachiae, the Cortex Eucommiae and Fructus Malvae as major ingredient, obtain extract powder through decocting, concentrate, being dried at raw material in preparation process, and the effective ingredient for the treatment of urinary tract infection medicine is provided; And steviosin and dextrin composition adjuvant, dextrin is preparation need of production as filler, in order to increase the weight and volume of tablet, steviosin as correctives in order to improve mouthfeel.Ratio between major ingredient (or extract powder) and adjuvant is not limited, and must depend on the circumstances according to production requirement.
Urinary tract infection is attributed to the category of traditional Chinese medical science stranguria, according to theory of Chinese medical science, etiology and pathogenesis analysis is drawn, the cause of disease of urinary tract infection is taking damp and hot as main, the present invention is directed to the cause of disease and adopts heat-clearing and toxic substances removing, method that dampness removing is treating stranguria, dispel damp and hot, blood circulation promoting and blood stasis dispelling, unimpeded mechanism of qi.The present invention is taking Cortex Phellodendri as monarch drug, heat clearing and damp drying, detoxification sore treatment; Taking the Radix Angelicae Dahuricae, Herba Lysimachiae and Fructus Malvae as ministerial drug, auxiliary monarch drug heat clearing and damp drying, eliminating fire and detoxication, can also expelling wind and cold, dissipating blood stasis for subsidence of swelling, understand things pain-stopping; Using Radix Scutellariae, Radix Bupleuri, Cortex Acanthopancis, Fructus Schisandrae Chinensis and the Cortex Eucommiae as adjuvant drug, excessive bitter cold in alleviation the monarch and his subjects medicine and excessively strong dampness ability, and there is reconciling superficies and interior, soothing the liver yang invigorating, restrain effect astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, also strengthen the water transport ability of Liver and kidney and the ability of bacteriostasis and sterilization, and promoted pathogenic bacteria to discharge with urine; With Radix Glycyrrhizae for making medicine, invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription; Above-mentioned Ten Herbs cooperatively interacts, clearing away heat-damp and promoting diuresis, and blood circulation promoting and blood stasis dispelling, bactericidal, functions of detumescence, relieving inflammation, treating both the principal and secondary aspects of a disease, reaches the effect of better treatment urinary tract infection.Confirm through clinical trial, cure rate of the present invention is 64%, and obvious effective rate is 20%, and effective percentage is 14%, and total effective rate is 98%.
Detailed description of the invention
Below, by specific embodiment, technical scheme of the present invention is elaborated.
Embodiment 1
The present invention proposes a kind of pharmaceutical composition for the treatment of urinary tract infection, and its raw material comprises major ingredient and adjuvant, and its major ingredient comprises by weight: 12 parts of Cortex Phellodendris, 12 parts of Radix Bupleuri, 8 parts of Radix Scutellariaes, 10 parts of Cortex Acanthopanciss, 10 parts of Fructus Schisandrae Chinensis, 10 parts of the Radixs Angelicae Dahuricae, 10 parts, Radix Glycyrrhizae, 10 parts of Herba Lysimachiaes, 10 parts of the Cortexs Eucommiae, 12 parts of Fructus Malvae; Its adjuvant by steviosin and dextrin by weight forming for 1:122.
The present invention also proposes a kind of preparation method of pharmaceutical composition of above-mentioned treatment urinary tract infection, using Cortex Phellodendri, Radix Bupleuri, Radix Scutellariae, Cortex Acanthopancis, Fructus Schisandrae Chinensis, the Radix Angelicae Dahuricae, Radix Glycyrrhizae, Herba Lysimachiae, the Cortex Eucommiae and Fructus Malvae as major ingredient, drop in extraction pot, decoct with water for the first time after 1.5h, add water for the second time and decoct again 1h and obtain decoction liquor twice, the water adding for the first time and the weight ratio of major ingredient are 9:1, and the water adding for the second time and the weight ratio of major ingredient are 7:1; After twice decoction liquor merged, filter and obtain filtering residue and filtrate; Filtrate is crossed after 95 mesh sieves, in the time of 92 DEG C, be concentrated into relative density and be 1.24 extractum; Extractum is crossed after atomization drying to 85 mesh sieves and obtained extract powder; Extract powder and adjuvant are mixed, granulate, are dried, sieve and are get final product.
Embodiment 2
The present invention proposes a kind of pharmaceutical composition for the treatment of urinary tract infection, and its raw material comprises major ingredient and adjuvant, and its major ingredient comprises by weight: 10 parts of Cortex Phellodendris, 13 parts of Radix Bupleuri, 7 parts of Radix Scutellariaes, 11 parts of Cortex Acanthopanciss, 9 parts of Fructus Schisandrae Chinensis, 11 parts of the Radixs Angelicae Dahuricae, 9 parts of Herba Lysimachiaes, 11 parts of the Cortexs Eucommiae, 11 parts of Fructus Malvae, 11 parts, Radix Glycyrrhizae; Its adjuvant by steviosin and dextrin by weight forming for 1:121.
The present invention also proposes a kind of preparation method of pharmaceutical composition of above-mentioned treatment urinary tract infection, using Cortex Phellodendri, Radix Bupleuri, Radix Scutellariae, Cortex Acanthopancis, Fructus Schisandrae Chinensis, the Radix Angelicae Dahuricae, Radix Glycyrrhizae, Herba Lysimachiae, the Cortex Eucommiae and Fructus Malvae as major ingredient, drop in extraction pot, decoct with water for the first time after 2.3h, add water for the second time and decoct again 1.6h and obtain decoction liquor twice, the water adding for the first time and the weight ratio of major ingredient are 7.8:1, and the water adding for the second time and the weight ratio of major ingredient are 5.5:1; After twice decoction liquor merged, filter and obtain filtering residue and filtrate; Filtrate is crossed after 102 mesh sieves, in the time of 89 DEG C, be concentrated into relative density and be 1.27 extractum; Extractum is crossed after atomization drying to 78 mesh sieves and obtained extract powder; Extract powder and adjuvant are mixed, granulate, are dried, sieve and are get final product.
Embodiment 3
The present invention proposes a kind of pharmaceutical composition for the treatment of urinary tract infection, its raw material comprises major ingredient and adjuvant, and its major ingredient comprises by weight: 13 parts of Cortex Phellodendris, 11.2 parts of Radix Bupleuri, 8.3 parts of Radix Scutellariaes, 9.6 parts of Cortex Acanthopanciss, 10.2 parts of Fructus Schisandrae Chinensis, 9.7 parts of the Radixs Angelicae Dahuricae, 10.4 parts of Herba Lysimachiaes, 9.5 parts of the Cortexs Eucommiae, 12.3 parts of Fructus Malvae, 9.4 parts, Radix Glycyrrhizae; Its adjuvant by steviosin and dextrin by weight forming for 1:123.
The present invention also proposes a kind of preparation method of pharmaceutical composition of above-mentioned treatment urinary tract infection, using Cortex Phellodendri, Radix Bupleuri, Radix Scutellariae, Cortex Acanthopancis, Fructus Schisandrae Chinensis, the Radix Angelicae Dahuricae, Radix Glycyrrhizae, Herba Lysimachiae, the Cortex Eucommiae and Fructus Malvae as major ingredient, drop in extraction pot, decoct with water for the first time after 2h, add water for the second time and decoct again 1.5h and obtain decoction liquor twice, the water adding for the first time and the weight ratio of major ingredient are 8:1, and the water adding for the second time and the weight ratio of major ingredient are 6:1; After twice decoction liquor merged, filter and obtain filtering residue and filtrate; Filtrate is crossed after 100 mesh sieves, in the time of 90 DEG C, be concentrated into relative density and be 1.26 extractum; Extractum is crossed after atomization drying to 80 mesh sieves and obtained extract powder; Extract powder and adjuvant are mixed, granulate, are dried, sieve and are get final product.
Embodiment 4
The present invention proposes a kind of pharmaceutical composition for the treatment of urinary tract infection, and its raw material comprises major ingredient and adjuvant, and its major ingredient comprises by weight: 14 parts of Cortex Phellodendris, 11 parts of Radix Bupleuri, 9 parts of Radix Scutellariaes, 9 parts of Cortex Acanthopanciss, 11 parts of Fructus Schisandrae Chinensis, 9 parts of the Radixs Angelicae Dahuricae, 11 parts of Herba Lysimachiaes, 9 parts of the Cortexs Eucommiae, 13 parts of Fructus Malvae, 9 parts, Radix Glycyrrhizae; Its adjuvant by steviosin and dextrin by weight forming for 1:125.
The present invention also proposes a kind of preparation method of pharmaceutical composition of above-mentioned treatment urinary tract infection, using Cortex Phellodendri, Radix Bupleuri, Radix Scutellariae, Cortex Acanthopancis, Fructus Schisandrae Chinensis, the Radix Angelicae Dahuricae, Radix Glycyrrhizae, Herba Lysimachiae, the Cortex Eucommiae and Fructus Malvae as major ingredient, drop in extraction pot, decoct with water for the first time after 2.5h, add water for the second time and decoct again 2h and obtain decoction liquor twice, the water adding for the first time and the weight ratio of major ingredient are 7:1, and the water adding for the second time and the weight ratio of major ingredient are 5:1; After twice decoction liquor merged, filter and obtain filtering residue and filtrate; Filtrate is crossed after 105 mesh sieves, in the time of 88 DEG C, be concentrated into relative density and be 1.28 extractum; Extractum is crossed after atomization drying to 75 mesh sieves and obtained extract powder; Extract powder and adjuvant are mixed, granulate, are dried, sieve and are get final product.
Embodiment 5
The present invention proposes a kind of pharmaceutical composition for the treatment of urinary tract infection, its raw material comprises major ingredient and adjuvant, and its major ingredient comprises by weight: 11 parts of Cortex Phellodendris, 12.4 parts of Radix Bupleuri, 7.5 parts of Radix Scutellariaes, 10.1 parts of Cortex Acanthopanciss, 9.3 parts of Fructus Schisandrae Chinensis, 10.5 parts of the Radixs Angelicae Dahuricae, 9.9 parts of Herba Lysimachiaes, 10.3 parts of the Cortexs Eucommiae, 11.6 parts of Fructus Malvae, 10.4 parts, Radix Glycyrrhizae; Its adjuvant by steviosin and dextrin by weight forming for 1:124.
The present invention also proposes a kind of preparation method of pharmaceutical composition of above-mentioned treatment urinary tract infection, using Cortex Phellodendri, Radix Bupleuri, Radix Scutellariae, Cortex Acanthopancis, Fructus Schisandrae Chinensis, the Radix Angelicae Dahuricae, Radix Glycyrrhizae, Herba Lysimachiae, the Cortex Eucommiae and Fructus Malvae as major ingredient, drop in extraction pot, decoct with water for the first time after 1.8h, add water for the second time and decoct again 1.4h and obtain decoction liquor twice, the water adding for the first time and the weight ratio of major ingredient are 8.3:1, and the water adding for the second time and the weight ratio of major ingredient are 6.4:1; After twice decoction liquor merged, filter and obtain filtering residue and filtrate; Filtrate is crossed after 93 mesh sieves, in the time of 91 DEG C, be concentrated into relative density and be 1.25 extractum; Extractum is crossed after atomization drying to 82 mesh sieves and obtained extract powder; Extract powder and adjuvant are mixed, granulate, are dried, sieve and are get final product.
Adopt embodiment 3 to prepare medicament, three times on the one, each 10g, two weeks is a course for the treatment of.Choose at random 100 cases of urinary tract infections, wherein upper urinary tract infection 52 examples, lower urinary tract infection 48 examples.After 2 courses for the treatment of, 64 examples of fully recovering altogether, effective 20 examples, effective 14 examples, invalid 2 examples.Cure rate of the present invention is 64%, and obvious effective rate is 20%, and effective percentage is 14%, and total effective rate is 98%, and inefficiency is 2%.
The wherein diagnostic criteria of urinary tract infection (being the standard that the academic meeting of Second China National nephropathy is passed through) is:
1, regular CCMS (require urine rest in bladder more than 4-6 hour) bacteria quantified is cultivated, clump count >=105/ml, and within 2 days, planted agent repeats to cultivate 1 time;
2, with reference to clean centrifugal stage casing uropsammus examination, leukocyte > 10/HP, or (possessing above-mentioned 1,2 can make a definite diagnosis urinary tract infection symptom person; As remake and urinate bacterium count check without 2, as still >=105/ml, and twice identical person of antibacterial, can make a definite diagnosis);
3, make punctio vesicae urine and cultivate, as positive for bacteria, can make a definite diagnosis;
4, do urine bacterium and cultivate the person of having any problem, midstream urine in early morning (urine stays in more than bladder 4-6 hour) before available treatment, the centrifugal Urine sediments analyzer Gram’s staining of canonical procedure is looked for antibacterial, mirror as oily in antibacterial > 1/ visual field, in conjunction with clinical urinary tract infection symptom, can make a definite diagnosis;
5, urine bacterial population person between 104-105/ml, should check, and as being still 104-105/ml, need diagnosing or do the cultivation of punctio vesicae urine and make a definite diagnosis in conjunction with clinical manifestation.
The wherein criterion of urinary tract infection therapeutic effect:
1, recovery from illness: the disappearance of clinical symptoms sign, it is normal that routine urianlysis recovers for 2 times, urine bacterium feminine gender, and urinate bacterium 1 time in check in the 2nd, 6 weeks, and all negative, be recent healing; Following the trail of 6 months is healing completely without recidivist;
2, effective: clinical symptoms sign alleviates or substantially disappears, routine urinalysis is normal or approach normally urine bacterium feminine gender;
3, effective: clinical symptoms, sign alleviate, and routine urinalysis significantly improves, urine is cultivated the even positive that has;
4, invalid: symptom and urine examination improve not obvious, the quantitative check of urine bacterium is still positive, or it is positive in the time within the 1st, 6 weeks, checking, to urinate bacterium, and is same strain.
The above; it is only preferably detailed description of the invention of the present invention; but protection scope of the present invention is not limited to this; any be familiar with those skilled in the art the present invention disclose technical scope in; be equal to replacement or changed according to technical scheme of the present invention and inventive concept thereof, within all should being encompassed in protection scope of the present invention.
Claims (9)
1. treat the pharmaceutical composition of urinary tract infection for one kind, it is characterized in that, its raw material comprises by weight: Cortex Phellodendri 10-14 part, Radix Bupleuri 11-13 part, Radix Scutellariae 7-9 part, Cortex Acanthopancis 9-11 part, Fructus Schisandrae Chinensis 9-11 part, Radix Angelicae Dahuricae 9-11 part, Herba Lysimachiae 9-11 part, Cortex Eucommiae 9-11 part, Fructus Malvae 11-13 part, Radix Glycyrrhizae 9-11 part.
2. treat according to claim 1 the pharmaceutical composition of urinary tract infection, it is characterized in that, the weight ratio of Radix Bupleuri, Radix Scutellariae, Cortex Acanthopancis, Fructus Schisandrae Chinensis, the Radix Angelicae Dahuricae and Herba Lysimachiae is 11.2-12.4:7.5-8.3:9.6-10.1:9.3-10.2:9.7-10.5:9.9-10.4.
3. treat according to claim 2 the pharmaceutical composition of urinary tract infection, it is characterized in that, its raw material comprises by weight: Cortex Phellodendri 11-13 part, Radix Bupleuri 11.2-12.4 part, Radix Scutellariae 7.5-8.3 part, Cortex Acanthopancis 9.6-10.1 part, Fructus Schisandrae Chinensis 9.3-10.2 part, Radix Angelicae Dahuricae 9.7-10.5 part, Herba Lysimachiae 9.9-10.4 part, Cortex Eucommiae 9.5-10.3 part, Fructus Malvae 11.6-12.3 part, Radix Glycyrrhizae 9.4-10.4 part.
4. according to the pharmaceutical composition for the treatment of urinary tract infection described in claim 2 or 3, it is characterized in that, its raw material comprises by weight: 12 parts of Cortex Phellodendris, 12 parts of Radix Bupleuri, 8 parts of Radix Scutellariaes, 10 parts of Cortex Acanthopanciss, 10 parts of Fructus Schisandrae Chinensis, 10 parts of the Radixs Angelicae Dahuricae, 10 parts, Radix Glycyrrhizae, 10 parts of Herba Lysimachiaes, 10 parts of the Cortexs Eucommiae, 12 parts of Fructus Malvae.
5. the pharmaceutical composition for the treatment of according to claim 4 urinary tract infection, is characterized in that, its raw material also comprises adjuvant, adjuvant by steviosin and dextrin by weight forming for 1:121-125.
6. the pharmaceutical composition for the treatment of according to claim 5 urinary tract infection, is characterized in that, its raw material also comprises adjuvant, adjuvant by steviosin and dextrin by weight forming for 1:123.
7. one kind according to the preparation method for the treatment of the pharmaceutical composition of urinary tract infection described in claim 1-6 any one, it is characterized in that, using Cortex Phellodendri, Radix Bupleuri, Radix Scutellariae, Cortex Acanthopancis, Fructus Schisandrae Chinensis, the Radix Angelicae Dahuricae, Radix Glycyrrhizae, Herba Lysimachiae, the Cortex Eucommiae and Fructus Malvae as major ingredient, drop in extraction pot, decoct with water for the first time after 1.5-2.5h, add water for the second time and decoct again 1-2h and obtain decoction liquor twice, the water adding for the first time and the weight ratio of major ingredient are 7-9:1, and the water adding for the second time and the weight ratio of major ingredient are 5-7:1; After twice decoction liquor merged, filter and obtain filtering residue and filtrate; Filtrate is crossed after 95-105 mesh sieve, in the time of 88-92 DEG C, be concentrated into the extractum that relative density is 1.24-1.28; Extractum is crossed after atomization drying to 75-85 mesh sieve and obtained extract powder; Extract powder and adjuvant are mixed, granulate, are dried, sieve and are get final product.
8. treat according to claim 7 the preparation method of the pharmaceutical composition of urinary tract infection, it is characterized in that, using Cortex Phellodendri, Radix Bupleuri, Radix Scutellariae, Cortex Acanthopancis, Fructus Schisandrae Chinensis, the Radix Angelicae Dahuricae, Radix Glycyrrhizae, Herba Lysimachiae, the Cortex Eucommiae and Fructus Malvae as major ingredient, drop in extraction pot, decoct with water for the first time after 1.8-2.3h, add water for the second time and decoct again 1.4-1.6h and obtain decoction liquor twice, the water adding for the first time and the weight ratio of major ingredient are 7.8-8.3:1, and the water adding for the second time and the weight ratio of major ingredient are 5.5-6.4:1; After twice decoction liquor merged, filter and obtain filtering residue and filtrate; Filtrate is crossed after 93-102 mesh sieve, in the time of 89-91 DEG C, be concentrated into the extractum that relative density is 1.25-1.27; Extractum is crossed after atomization drying to 78-82 mesh sieve and obtained extract powder; Extract powder and adjuvant are mixed, granulate, are dried, sieve and are get final product.
9. according to the preparation method of pharmaceutical composition for the treatment of urinary tract infection described in claim 7 or 8, it is characterized in that, using Cortex Phellodendri, Radix Bupleuri, Radix Scutellariae, Cortex Acanthopancis, Fructus Schisandrae Chinensis, the Radix Angelicae Dahuricae, Radix Glycyrrhizae, Herba Lysimachiae, the Cortex Eucommiae and Fructus Malvae as major ingredient, drop in extraction pot, decoct with water for the first time after 2h, adding water for the second time decocts 1.5h again and obtains decoction liquor twice, and the water adding for the first time and the weight ratio of major ingredient are 8:1, and the water adding for the second time and the weight ratio of major ingredient are 6:1; After twice decoction liquor merged, filter and obtain filtering residue and filtrate; Filtrate is crossed after 100 mesh sieves, in the time of 90 DEG C, be concentrated into relative density and be 1.26 extractum; Extractum is crossed after atomization drying to 80 mesh sieves and obtained extract powder; Extract powder and adjuvant are mixed, granulate, are dried, sieve and are get final product.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105362502A (en) * | 2015-11-16 | 2016-03-02 | 宁国仙霞骨伤医院 | Traditional Chinese medicine composition for treating stranguria |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1559535A (en) * | 2004-03-09 | 2005-01-05 | 陈玲玲 | Chinese medicine oral preparaton for treating urinary system infestation and its preparation method |
| CN1839997A (en) * | 2006-01-17 | 2006-10-04 | 张宏业 | Medicinal capsule for treating urinary system disease and preparation method thereof |
| CN1903281A (en) * | 2006-08-01 | 2007-01-31 | 兰玉岐 | Traditional Chinese medicine composition for treating urinary system infection |
| CN101518584A (en) * | 2009-04-15 | 2009-09-02 | 河北大学 | Traditional Chinese medicine for curing urinary system infection and preparation method thereof |
| CN103705818A (en) * | 2014-01-16 | 2014-04-09 | 张云刚 | Traditional Chinese medicine for treating non-gonococcal urethritis |
-
2014
- 2014-09-25 CN CN201410497599.4A patent/CN104189199A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1559535A (en) * | 2004-03-09 | 2005-01-05 | 陈玲玲 | Chinese medicine oral preparaton for treating urinary system infestation and its preparation method |
| CN1839997A (en) * | 2006-01-17 | 2006-10-04 | 张宏业 | Medicinal capsule for treating urinary system disease and preparation method thereof |
| CN1903281A (en) * | 2006-08-01 | 2007-01-31 | 兰玉岐 | Traditional Chinese medicine composition for treating urinary system infection |
| CN101518584A (en) * | 2009-04-15 | 2009-09-02 | 河北大学 | Traditional Chinese medicine for curing urinary system infection and preparation method thereof |
| CN103705818A (en) * | 2014-01-16 | 2014-04-09 | 张云刚 | Traditional Chinese medicine for treating non-gonococcal urethritis |
Non-Patent Citations (1)
| Title |
|---|
| 朴志贤主编: "《肾脏病临床诊治》", 31 January 2006 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105362502A (en) * | 2015-11-16 | 2016-03-02 | 宁国仙霞骨伤医院 | Traditional Chinese medicine composition for treating stranguria |
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Effective date of registration: 20160510 Address after: 454000 Jiaozuo urban and rural integration demonstration area Yuxi Road, Henan Province Applicant after: Jiangsu Pingguang Xinyi (Jiaozuo) Chinese medicine limited company Address before: Xifei River Road Changfeng Shuangfeng Economic Development Zone of Hefei City, Anhui Province, No. 008 231131 Applicant before: HEFEI PINGGUANG PHARMACEUTICAL CO., LTD. |
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