CN104398969A

CN104398969A - Post-renal transplantation treating and health care traditional Chinese medicine

Info

Publication number: CN104398969A
Application number: CN201410589323.9A
Authority: CN
Inventors: 刘佰祥
Original assignee: Individual
Current assignee: Individual
Priority date: 2014-10-22
Filing date: 2014-10-22
Publication date: 2015-03-11
Anticipated expiration: 2034-10-22
Also published as: CN104398969B

Abstract

The invention discloses a post-renal transplantation treating and health care traditional Chinese medicine. The post-renal transplantation treating and health care traditional Chinese medicine comprises active components and auxiliary materials. The active components comprise, by weight, 10-18 parts of turmeric, 15-30 parts of glossy privet fruits, 6-10 parts of bighead atractylodes rhizome, 10-15 parts of oriental wormwood, 8-12 parts of radix lsatidis, 10-15 parts of lysimachia christinae hance, 10-15 parts of polygonum cuspidatum, 5-10 parts of schisandra chinensis and 10-15 parts of Chinese dates. The post-renal transplantation treating and health care traditional Chinese medicine has the effects of detoxification, dampness resolving, kidney strengthening, liver protection, spleen tonifying, blood nourishing, blood circulation invigorating, diureses and heart strengthening; the physiological function of the kidney can be effectively strengthened; and drug-induced liver cirrhosis and renal fibrosis are prevented. Obvious treatment and prevention effects on edema, hydronephrosis, the fatty liver and the like are achieved. The post-renal transplantation treating and health care traditional Chinese medicine is used for post-renal transplantation, the rejection resisting capacity of the transplant kidney can be improved; and toxic and side effects of immunosuppressant on the liver and the kidney are reduced. The chronic allograft nephropathy can be prevented, and the comprehensive health care effect is achieved.

Description

A kind of Post kidney transplantation treatment and health Chinese medicine

Technical field

The invention belongs to Chinese herbal medicine preparing technical field, be specifically related to a kind of Post kidney transplantation treatment and health compound Chinese medicinal preparation.

Background technology

How Post kidney transplantation, allow operation receiveing person's long-term health survive, and is a difficult problem of medical circle always.The domestic and international insider of tool investigates proof: in recent years, although make great progress in distribution type technology and operation level, immunosuppressant is also in continuous renewal, survival rate in renal transplantation 10 years is greatly improved, but send out in disease and chronic allograft nephropathy (chronic kidney is lost) in treatment and prevention Shu Hou Merger, few of breakthrough, and compares in the past, and long-term surviving rate does not obviously change.This has become the global difficult problem together in renal transplantation.Prevention rejection and chronic kidney are lost, and traditional viewpoint is thought, selects with better function, more senior immunosuppressant, or takes the way of escalated dose, reduce the immunocompetence of body further.But use immunosuppressant in a large number, can cause heavier financial burden to operation receiveing person on the one hand, on the other hand, operation receiveing person produces Zhu Duo Merger and sends out disease because immune function declines to a great extent, sometimes may cause very serious consequence.Though some people often can be seen in clinical not reject, be badly damaged harmful because of liver or get killed because of pulmonary's fungal infection.In order to treat and prevent produced problem, while taking anti-rejection medication, also to take some adjuvant therapy medicaments.As: hepatoprotective, BAOSHEN YAO.Uric acid resisting medicine, depressor, reducing blood viscosity medicine ... etc. (sometimes will take nearly several very to tens kinds).Remaining attends to one thing and lose sight of another like this is difficult to save from damage.

Summary of the invention

The object of the present invention is to provide a kind of Post kidney transplantation to protect the liver, protect kidney, improve transplanted kidney physiological function, prevention rejection and chronic kidney are lost, and prevent the Chinese medicine compound novel formulation of post-operative complication.

To achieve the above object of the invention, the technical solution used in the present invention is:

A kind of Post kidney transplantation treatment and health Chinese medicine, comprise active component and adjuvant, counting its active component is by weight: Rhizoma Curcumae Longae 10-18 part, Fructus Ligustri Lucidi 15-30 part, Rhizoma Atractylodis Macrocephalae 6-10 part, Herba Artemisiae Scopariae 10-15 part, Radix Isatidis 8-12 part, Herba Lysimachiae 10-15 part, Rhizoma Polygoni Cuspidati 10-15 part, Fructus Schisandrae Chinensis 5-10 part, Fructus Jujubae 10-15 part.

Further, described Post kidney transplantation treatment and health Chinese medicine, counting its active component is by weight: 15 parts, Rhizoma Curcumae Longae, Fructus Ligustri Lucidi 20 parts, the Rhizoma Atractylodis Macrocephalae 8 parts, Herba Artemisiae Scopariae 12 parts, Radix Isatidis 10 parts, Herba Lysimachiae 12 parts, Rhizoma Polygoni Cuspidati 12 parts, Fructus Schisandrae Chinensis 8 parts, 12 parts, Fructus Jujubae.

Further, described Post kidney transplantation treatment and health Chinese medicine can be made into tablet, granule or capsule.

Further preferably, concentrated capsule preparations made by described Post kidney transplantation treatment and health Chinese medicine.

Another object of the present invention is to the preparation method that a kind of described Post kidney transplantation treatment and health Chinese medicine is provided: by weight proportion, by above crude drug decoction pieces, well sifted remove impurity is for subsequent use; Beat powder after getting Rhizoma Curcumae Longae, the Rhizoma Atractylodis Macrocephalae, Radix Isatidis, three kinds of medicine mixing in proportion, cross 80 mesh sieves, obtain fine powder, for subsequent use; All the other flavour of a drug soak four hours, and the adjustment water yield there was not medicine 4-5cm, and normal pressure decocts three times, often all over two hours, merged medicinal liquid, after being condensed into cream, adding above medicated powder, mix well, the dry rear pulverizing of the universe after filtration, crossed 14 mesh sieves, made granule coarse powder, fill No. 0 capsule; Every powder charge powder 0.5g.

Therapeutic dose: every day two to three times, each five;

Postoperative health care: every day secondary, each four (body weight 60-80kg) body weight are excessive, suitable dosage.Anemia of pregnant woman is cautious use of.

Chinese medicine composition of the present invention, is formed by nine taste Chinese herbal medicine compatibilities such as Rhizoma Curcumae Longae, Fructus Ligustri Lucidi, the Rhizoma Atractylodis Macrocephalae, Herba Artemisiae Scopariae, Radix Isatidis, Herba Lysimachiae, Rhizoma Polygoni Cuspidati, Fructus Schisandrae Chinensis, Fructus Jujubaes.

Fructus Ligustri Lucidi in side: be the dry mature fruit of Oleaceae plants Fructus Ligustri Lucidi.Gather during fruit maturation in winter.

Concoct: removing branch and leaf, after slightly steaming or putting in boiling water and slightly scald, dry.

Nature and flavor with return through sweet, bitter, cold.Return liver, kidney channel.

Function with cure mainly: nourishing the liver and kidney, improving eyesight black hair.For dizzy, tinnitus, soreness of the waist and knees, early whitening of beard and hair, poor vision.There is nourishing the liver and kidney, merit that tonifying YIN nourishes blood.

Pharmacological action: modern medicine study proves, Fructus Ligustri Lucidi includes ursolic acid, mannitol, glucose, fatty wet goods, there are heart tonifying, diuresis and hepatoprotective effect, the leukopenia quantity caused because of chemotherapy can be made to raise, and have inhibitory action to staphylococcus aureus, escherichia coli.In recent years, there is people to treat chronic hepatitis with it, obtained definite curative effect.This is because containing oleanolic acid, mannitol, linoleic acid, Fructus Ligustri Lucidi element etc. in his chemical analysis, and a large amount of glucose.And modern pharmacology analysis shows, oleanolic acid has leukocyte increasing, the acute and chronic liver injury that antagonism carbon tetrachloride causes, and prevents hepatitis interstitialis chronica, promotes the function of liver cell regeneration; And have the effect such as heart tonifying, diuresis.

The Rhizoma Atractylodis Macrocephalae: be the dry rhizome of the feverfew Rhizoma Atractylodis Macrocephalae.Excavate when withered and yellow, the upper blade of inferior leads in winter becomes fragile, removing silt, dries or dries, then remove fibrous root.

Concoct: removing impurity, clean, run through, cut sheet, dry.

Nature and flavor with return through: bitter, sweet, temperature.Return spleen, stomach warp.

Function with cure mainly: invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention, dizzy, edema, spontaneous perspiration, frequent fetal movement.

Pharmacological action

(1) experiment in vitro tool active anticancer.

(2) volatile oil has cytotoxicity; Stronger inhibitory action is had to cancer cell.

(3) body hormonal regulation and enzyme system function can be promoted, strengthen antineoplastic immunization.

(4) decoct all has obvious and lasting diuresis to kind animals such as rat, rabbit, Canis familiaris L.s; To not anaesthetizing Canis familiaris L. venous pulse injection decoct 0.05 ~ 0.25 g/kg, urine volume increase reaches more than 9 times; As with gastric infusion 1 ~ 3 g/kg, urine volume comparatively can increase by 2 ~ 6 times before medication, and majority in medication after 6 ~ 7 hours still more than normal output, not only increase the excretion of water, and amount of electrolyte absorbed reduce, too increase the output of sodium and chlorine.

(5) decoct gavages to rabbit and blood glucose can be made in a slight decrease; The assimilation of glucose in acceleration bodies is had thus to fall hypoglycemic effect to rats gavaged; There is the liver protecting to mouse gavaging, prevent carbon tetrachloride from causing the effects such as liver glycogen minimizing.

(6) rat gavages decoct 0.5 g/kg every day, totally 1 ~ 4 week, can make prothrombin time significant prolongation; Healthy People takes each 1 soupspoon of decoct (1: 20), 3 times on the 1st, prothrombin time and the equal significant prolongation of clotting time after 4 days, and drug withdrawal just recovers normal after 10 days.

(7) mice to gavage decoct 6 gs/kg every day 1 month, can promote that its body weight increases; And with the provable effect having muscle strength reinforcing of swimming test.

(8) decoct declines to the leukocyte caused by chemotherapy or X-ray therapy the effect making it raise.

Rhizoma Curcumae Longae:

The dry rhizome of zingiberaceous plant Rhizoma Curcumae Longae.In winter, excavate when stem and leaf is withered, clean, boil or steam to the saturating heart, drying, removing fibrous root.

Concoct: removing impurity, slightly bubble, clean, run through, cut sheet, dry.

Nature and flavor with return through: pungent, bitter, temperature.Return spleen, Liver Channel.

Function with cure mainly: removing blood stasis circulation of qi promoting, inducing menstruation to relieve menalgia.For the twinge of the breast side of body, amenorrhea ， mass in the abdomen, rheumatism shoulder arm pain, tumbling and swelling.

Chemical composition: root stock is containing curcumin about 0.3%, volatile oil about 1 ~ 5%, and in oil, main component is turmerone and dihydro turmerone 50%, zingiberene 20% phellandrene 1%, eucalyptol 1% etc.In addition, still containing starch 30 ~ 40%, a small amount of fatty oil.

Pharmacological action: (1) function of gallbladder promoting: 50% Rhizoma Curcumae Longae decocting liquid, hydrochloric acid leachate all have obvious choleretic effect, and its choleretic effect all can maintain 1 ~ 2 hour.Yellow contained by Rhizoma Curcumae Longae have contraction gallbladder, eliminates the effect of obstructive jaundice.

(2) 50% Curcumas have the effect in excited uterus, uterus can be made to produce paroxysmal constriction, can maintain 5 ~ 7 hours.

(3) ether extract of Rhizoma Curcumae Longae is oral to the rabbit of hypercholesterolemia, makes its cholesterolemia drop to 36 milligrams of % from 266 milligrams of % in three weeks.

(4) in Mice Body or intracranial inoculation Viral Assay, result proves, Rhizoma Curcumae Longae group is long compared with the life span of control animals.

(5) antibacterial: the water logging agent of Rhizoma Curcumae Longae has bacteriostasis to Common Pathogenic dermatophytes in vitro.Rhizoma Curcumae Longae has inhibitory action to hepatitis virus, is improved the effect of liver parenchyma disease damage.

Curcumol extract, Rhizoma Curcumae Longae volatile oil and curcumin can make the T-CHOL in aorta, content of triglyceride reduces; Inhibitory action is had to platelet aggregation; Rhizoma Curcumae Longae have the effect increasing fibrinolytic, and therefore, Rhizoma Curcumae Longae has antiatherogenic effect.

Herba Artemisiae Scopariae:

For the ground drying nest of feverfew Artemisia scoparia Waldst. et Kit. or Herba Artemisiae Scopariae.Gather during the high 6 ~ 10cm of seedling in spring or autumn taps when alabastrum is grown up, removing impurity and old stem, dry.The habit of gathering spring claims " capillary wormwood ", taps autumn claim " Herba Artemisiae Scopariae ".

Concoct: removing undesirable root and impurity, rub broken or chopping with the hands.Capillary wormwood sieve dedust bits.

Nature and flavor with return through: bitter, pungent, be slightly cold.Return spleen, stomach, liver, gallbladder meridian.

Function with cure mainly: clearing away damp-heat, jaundice eliminating subcutaneous ulcer.For jaundice oliguria, eczema pruritus; Infectious jaundice type hepatitis.Its volatile oil component has: Capillene, capillarin, capillin, capillin, Herba Artemisiae Scopariae alkynol; Deng, also containing three kinds of capillarisins.

Pharmacological action: Herba Artemisiae Scopariae water decoction, all has through animal experiment and promotes bile secretion effect, has and promotes liver cell regeneration effect, and have diuresis to rabbit; Herba Artemisiae Scopariae volatile oil can make urine volume increase to the rabbit of toxic hepatitis, and urine color is clear by xanthochromia.

Radix Isatidis:

For the dry root of cruciferae isatis.Autumn excavates, and removing silt, dries.

Concoct: removing impurity, clean, run through, cut sheet, dry.

Nature and flavor with return through: bitter, cold.GUIXIN, stomach warp.

Function with cure mainly: heat-clearing and toxic substances removing, removing heat from blood sore-throat relieving.For maculae caused by violent heat pathogen, crimson tongue is purple dark, mumps, sore throat, scarlet fever, major part pestilence, erysipelas, carbuncle.

Pharmacological action: 1. antibiosis and antiviral functions: Radix Isatidis has effect to various bacteria.Infusion is to bacillus subtilis, staphylococcus aureus, and sarcine, escherichia coli, Bacillus typhi, paratyphoid fever bacillus, dysentery (will Hayes, Fu Shi) bacillus, bacillus enteritidis etc. have inhibitory action; Acetone leachate also has similar effect, and to Hemolytic streptococcus effectively (all using agar aperture flat band method).Similar to the bacteriostasis of A type meningococcus and Bulbus Allii, Flos Lonicerae.

2. the Radix Isatidis of anti-leptospira effect more than 1: 100 or Folium Isatidis solution, all has the effect of killing Leptospira in trial operation.

3. Detoxication: it is reported, dog Radix Isatidis, Rhizoma Coptidis powder and Rhizoma et radix veratri (Radix Rhizoma Veratri), with taking (each 2.0g/kg), can separate Rhizoma et radix veratri (Radix Rhizoma Veratri) poison, reduce mortality rate; If again with it after veratrum poisoning, then invalid; Alone Radix Isatidis powder or Rhizoma Coptidis powder respectively, effect is also bad.

4. antitumor action: to rat w256 solid tumor and Mice Bearing Lewis Lung Cancer injection indirubin 200mg/kg, continuous 6-7 days, the suppression ratio of result to rat w256 solid tumor is respectively 47-50% and 50-58%, and when subcutaneous injection reduces to below 100mg/kg every day most, its inhibitory action is not obvious.Indirubin 500mg/kg gavage is 23-33% to the suppression ratio of rat w256 solid tumor, to the suppression ratio about 30% of sarcoma180.Indirubin can extend the life span about 20% of leukemic lymphoblastoid L7212 mice.In addition, prove through the test of Mouse Spermatogonial Cells method, indirubin can not suppress sperma-togonium B and spermatid specifically.

5. pair leukemia effect: pharmacological research tentatively shows, indirubin has the effect destroying leukaemia.From ultrastructural morphology, under indirubin effect, the cell of degeneration necrosis is swelling, lytic necrosis.Find in experiment that indirubin can strengthen the phagocytic activity of the Mononuclear phagocyte system of animal.Mononuclear phagocyte system plays a part certain in organism immune response, therefore the antitumaous effect of indirubin may be relevant with raising body immunity.

Herba Lysimachiae:

The dry herb of spring flower section Lysimachia christinae Hance.Summer, Qiu Erji gather, and removing impurity, dries.

Concoct: removing impurity, slightly wash, cutting, dry.

Nature and flavor with return through: sweet, salty, be slightly cold.Return liver, gallbladder, kidney, urinary bladder channel.

Function with cure mainly: eliminating damp-heat, treating stranguria, detumescence.For pyretic stranguria, Sha Lin, urinates and puckeryly to have a pain, jaundice, dark coloured urine carbuncle furuncle, venom, liver and bile stone, lithangiuria.

Pharmacological action: 1, calculus effect: Herba Lysimachiae has effect of cholagogic and lithagogue and diuresis and expelling stone.Show by Tinea Ranae experimental calcium oxalate renal calculus model test, Herba Lysimachiae decocts juice, is effective for prevention and therapy Tinea Ranae experimental kidney stone.Anesthesia Canis familiaris L., semi open model recording system experimental result shows, Herba Lysimachiae can cause proximal ureteral cavity pressure to increase, and ureteral peristalsis strengthens, and urine volume increases, and has extruding and percussion, impel ureteral calculus to discharge to ureteral calculus.Water calcium oxalate is the main component of lithangiuria, and the polysaccharide component in the alcohol-insoluble substances of Herba Lysimachiae has inhibitory action to the crystalline growth of water calcium oxalate,

2, antiinflammatory action Herba Lysimachiae 50g/kg and total flavones thereof and phenolic acid thing 3.75g/kg lumbar injection, significant inhibitory action is had to the mice vascular permeability increase that histamine causes, mouse ear inflammation caused by Oleum Tiglii is had to the inhibitory action of highly significant, the ankle swelling in rat cause albumen injection and rat granuloma swell and all have significant inhibitory action.

3, inhibitory action is had to immune system effect Herba Lysimachiae to cellular immunization.Rosette Test: Herba Lysimachiae mouse boosting cell and sheep red blood cell (SRBC) form the percentage rate of Flos Rosae Rugosae, are starkly lower than matched group, even if after drug withdrawal 10 days still suppressed, its degree is similar to cyclophosphamide.It is more obvious that Herba Lysimachiae and cyclophosphamide share suppression.Skin graft rejection reacts: the time that Herba Lysimachiae group and the graft-rejection of cyclophosphamide group mouse skin occur, all late than matched group, and two medicines also use group more so.Herba Lysimachiae also has inhibitory action to humoral immunization.The mice of immunity, take Herba Lysimachiae group Hemolysin formation suppressed, in serum, content is about 1/2 of matched group; It is suppressed that Herba Lysimachiae group mice generation leptospira coagulates molten antibody, and in serum, titre is generally lower than matched group;

4, there is relexation to the effect Herba Lysimachiae of vascular smooth muscle and human blood platelets to vascular smooth muscle, also have certain inhibitory action to the human platelet aggregation of in vitro ADP and arachidonic acid-induction.

5, toxicity clinical report Herba Lysimachiae can cause contact dermatitis and anaphylaxis.

Rhizoma Polygoni Cuspidati:

The dry rhizome of polygonaceae plant Rhizoma Polygoni Cuspidati and root.Spring, Qiu Erji excavate, and removing fibrous root, cleans, take advantage of fresh-cut and become short section or rear panel, dry.

Concoct: removing impurity, clean, run through, cut sheet, dry.

Nature and flavor with return through: micro-hardship, is slightly cold.Return liver, gallbladder, lung meridian.

Function with cure mainly: expelling wind and removing dampness, dissipating blood stasis analgesic therapy, relieving cough and resolving phlegm.For joint paralysis, jaundice due to damp-heat, amenorrhea ， mass in the abdomen, cough with copious phlegm, burn due to hot liquid or fire, injury from falling down, too fat to move sore.

Pharmacological action:

1, heart tonifying: polydatin has obvious positive inotropic action to working heart, does not accelerate heart rate.Isolated guinea pig heart contractive amplitude can be made to increase, strengthen myocardial contraction, improve circulation, increase coronary flow.

2, increase cardiac muscle nutritional blood flow, Rhizoma Polygoni Cuspidati injection mouse peritoneal is injected, and obviously can increase cardiac muscle nutritional blood flow, and have synergism with aminophylline.

3, expand blood capillary: severe hemorrhagic shock rat, after injection polydatin, three grades of arteriovenous calibers of contraction return to original level, and blood pressure moderate is gone up, and pulse pressure recovers normal.There is artery blood flow in blood capillary opening part, promotes the restoration of blood flow flowing of stagnating, thus improve the microcirculatory disorder of shock.

4, arrhythmia: to experimental rat ventricular tachycardia, Huzhang and polydatin make it fast quick-recovery sinus rate.

5, enzyme falls: resveratrol and polydatin have significantly suppression rat liver microsomal lipid peroxidation reaction to hepatocellular damage and fracture effect, can reduce serum GPT, GOT regulating liver-QI LP0.Huzhang is by promoting the reparation of animal liver cell, regenerating and the approach such as to reduce inflammation, and make liver function recovery normal, jaundice is removed.

6, HBsAg is suppressed: Huzhang has inhibitory action to HBsAg, and emodin and flavonoid can make hepatitis B antigen titre decline 8 times.Phenolic glycoside also has more weak inhibitory action to HBsg.

7, Rhizoma Polygoni Cuspidati has significantly increases liver bile secretion and the oddi sphincter effect that relaxes, and thus has choleretic effect.

8, antibacterial: Anthraquinones of Polygonum Cuspidatum Sieb class has the antibacterial action of wide spectrum.Resveratrol has very strong antibacterial action to multiple pathomycete.

9, antiviral: Huzhang all has stronger inhibitory action to multiple viruses such as Asia influenza virus, echovirus, Coxsackie virus, herpes simplex virus, adenoviruss.

10, anticancer: Rhizoma Polygoni Cuspidati emodin gavage, all there is significant curative effect to mice S180, rat liver cancer, mouse breast cancer, mice ehrlich carcinoma, mouse lymph sarcoma etc.Tannin From Polygonum Cuspidatum has anti-promoting and prevents the effect of canceration.

11, incidence rate and the case fatality rate of animal diabetes can be reduced.

12, Huzhang, polydatin, emodin all have antitussive effect.The guinea-pig isolated trachea that Huzhang can cause antihistamine shrinks, and has more weak spasmolytic antiasthmatic effect.

13, Tannin From Polygonum Cuspidatum has obvious scavenging hydroxyl free radical.

Fructus Schisandrae Chinensis:

The dry mature fruit of orchid Fructus Schisandrae Chinensis or yellow angledtwig magnoliavine fruit.The former practises title " Radix Schisandrae Bicoloris ", and the latter practises title " Fructus Schisandrae Sphenantherae ".Pluck during fruit maturation in autumn, dry or dry after steaming, removing carpopodium and impurity.

Concoct: removing impurity.Used time smashs to pieces.

Nature and flavor with return through: sour, sweet, temperature.Return lung, the heart, kidney channel.

Function with cure mainly: restrain astringent or styptic treatment for spontaneous sweating, the raw spleen of QI invigorating, kidney calming.For chronic cough dyspnea due to deficiency, emission, enuresis frequent micturition, incessant chronic diarrhea, spontaneous perspiration, night sweat, Tianjin wound is thirsty, and deficient pulse of losing heart, interior-heat is quenched one's thirst, palpitation and insomnia.

Pharmacological action:

1, Fructus Schisandrae Chinensis has antiinflammation: Fructus Schisandrae Chinensis has antiinflammation, to prevent hepar damnification, activate anabolic process to promote the reparation of wounded hepatocytes, and the activity of DNA (DNA) synthetic and ornithine decarboxylase can be strengthened, regeneration liver cell.Carbon tetrachloride (CCl4) be wherein a kind of to liver most poison material.Countless research displays, the potent liver-protecting efficacy of Fructus Schisandrae Chinensis can resist the toxic action of CCl4.Fructus Schisandrae Chinensis has very large effect at the liver protecting from daily toxin infringement as can be seen here!

2, protection and strengthen heart body: Fructus Schisandrae Chinensis is conducive to histiocytic oxygen exchange, and in the case of some anoxias and myocardial damage, has obtained confirmation and can produce protective effect to heart tissue.It also can palmic rate and alleviate hypertension gently.

3, intelligence is promoted sound: Fructus Schisandrae Chinensis can activate nervous system, promote respond, mental concentration and coordinative role, and it is clear to strengthen thinking.Although it has the effect of activation, there is no caffeine side effect restless.This slight berry, is also used to treat melancholia sometimes, and helps improvement agitation and forgetful problem.Strengthen device endurance, Fructus Schisandrae Chinensis energy stamina intensifying and strength also accelerate antisecosis.In Russia, show with the result of study that Plant personnel and child are subjects, Fructus Schisandrae Chinensis can promote endurance, physical strength reinforcing and minimizing disease.

4, anti-anti-free radical infringement: free radical causes the hypodynamic main cause of atherosclerosis, cancer, coronary heart disease and immunity, is also the arch-criminal causing ageing process to accelerate.Lignan contained by Fructus Schisandrae Chinensis is potent antioxidants, can suppress free radical, and can increase the level of the antioxidant-glutathion in liver.

5, delay the aging process: research report shows, and Fructus Schisandrae Chinensis is often used as the tonic of aging resistance and QI invigorating, and recent result of study more illustrates this principle.Research finds, the lignan contained by Fructus Schisandrae Chinensis can strengthen the energy production of adenosine triphyosphate (ATP) or mitochondrion (cellular energy storehouse), protects grain line body to encroach on from oxidative pressure simultaneously.These effects are enough to illustrate that why Fructus Schisandrae Chinensis can slow down ageing process and delay to occur ageing-related disease, as heart failure, Alzheimer disease and Parkinson's disease.

6, nourishing and enhancing kidney function: in the angle of the traditional Chinese medical science, Fructus Schisandrae Chinensis is often used to nourishing kidney and promotes the production of body fluid, and helps treatment night sweat, excessive thirst and pollakiuria problem, and also helpful in treatment urinary incontinence and premature ejaculation.

7, potent adaptation agent: Fructus Schisandrae Chinensis is that the most effective plant adapts to one of agent, can promote intelligence, physical ability and sense organ function, and strengthen the resistance to pressure.In brief, it can help human body to bear the pressure factor of such as hot and cold, noise, emotion over loading and so on, therefore contributes to promoting work performance, stamina intensifying and lessening fatigue.

Fructus Jujubae:

For the dry mature fruit of Rhamnaceae plant Fructus Jujubae.Gather during fruit maturation in autumn, dry.

Concoct: removing impurity, clean, dry.Used time breaks or enucleation.

Nature and flavor with return through: sweet, temperature.Return spleen, stomach warp.

Function with cure mainly: invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind.For insufficiency of the spleen lack of appetite, weak loose stool, woman hysteria.

The present invention, from theory of Chinese medical science, proposes by the method for anti-phase thinking, with raising transplanted kidney physiological function, strengthens the method for transplanted kidney self immunologic rejection ability, the new approaches of prevention rejection.In treatment and complication prevention and chronic allograft nephropathy, with kidney tonifying, spleen invigorating, heart tonifying, protect the liver as aim, prescription pharmacy.

The present invention has removing toxic substances removing dampness, kidney tonifying hepatoprotective, spleen invigorating, nourish blood, invigorate blood circulation, diuresis, heart tonifying function, effectively can strengthen the physiological function of kidney; Preventive drug physical property liver cirrhosis and renal fibrosis.To edema, hydronephrosis, fatty liver, etc. have significantly treatment and preventive effect.For Post kidney transplantation, the immunologic rejection ability of transplanted kidney can be improved, alleviate the toxic and side effects of immunosuppressant to liver, kidney.Prevent chronic allograft nephropathy, there is more comprehensive health-care effect.

Detailed description of the invention

Below in conjunction with embodiment to further instruction of the present invention, in embodiment, be parts by weight, but the present invention is not limited thereto.

Application Example one

Embodiment 1

By existing Chinese medicine crude drug decoction pieces standard, by weight proportion, by crude drug decoction pieces, well sifted remove impurity is for subsequent use; Beat powder after getting 18 parts, Rhizoma Curcumae Longae, the Rhizoma Atractylodis Macrocephalae 10 parts, Radix Isatidis 12 parts, three kinds of medicine mixing in proportion, cross 80 mesh sieves, obtain fine powder, for subsequent use; All the other flavour of a drug Fructus Ligustri Lucidi 30 parts, Herba Artemisiae Scopariae 15 parts, Herba Lysimachiae 15 parts, Rhizoma Polygoni Cuspidati 15 parts, Fructus Schisandrae Chinensis 10 parts, 15 parts, Fructus Jujubae soak four hours, the adjustment water yield there was not medicine 4-5cm, and normal pressure decocts three times, often all over two hours, medicinal liquid is merged after filtration, after being condensed into cream, adding above medicated powder, mix well, the dry rear pulverizing of the universe, cross 14 mesh sieves, make granule coarse powder, fill No. 0 capsule; Every powder charge powder 0.5g.

Embodiment 2

15 parts, Rhizoma Curcumae Longae, Fructus Ligustri Lucidi 20 parts, the Rhizoma Atractylodis Macrocephalae 8 parts, Herba Artemisiae Scopariae 12 parts, Radix Isatidis 10 parts, Herba Lysimachiae 12 parts, Rhizoma Polygoni Cuspidati 12 parts, Fructus Schisandrae Chinensis 8 parts, 12 parts, Fructus Jujubae;

Preparation method is with embodiment 1.

Embodiment 3

10 parts, Rhizoma Curcumae Longae, Fructus Ligustri Lucidi 15 parts, the Rhizoma Atractylodis Macrocephalae 6 parts, Herba Artemisiae Scopariae 10 parts, Radix Isatidis 8 parts, Herba Lysimachiae 10 parts, Rhizoma Polygoni Cuspidati 10 parts, Fructus Schisandrae Chinensis 5 parts, 10 parts, Fructus Jujubae;

Preparation method is with embodiment 1.

Embodiment 4

12 parts, Rhizoma Curcumae Longae, Fructus Ligustri Lucidi 25 parts, the Rhizoma Atractylodis Macrocephalae 8 parts, Herba Artemisiae Scopariae 14 parts, Radix Isatidis 12 parts, Herba Lysimachiae 10 parts, Rhizoma Polygoni Cuspidati 14 parts, Fructus Schisandrae Chinensis 8 parts, 10 parts, Fructus Jujubae;

Preparation method is with embodiment 1.

Embodiment 5

18 parts, Rhizoma Curcumae Longae, Fructus Ligustri Lucidi 18 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, Herba Artemisiae Scopariae 8 parts, Radix Isatidis 13 parts, Herba Lysimachiae 12 parts, Rhizoma Polygoni Cuspidati 15 parts, Fructus Schisandrae Chinensis 10 parts, 14 parts, Fructus Jujubae;

Preparation method is with embodiment 1.

Embodiment 6

16 parts, Rhizoma Curcumae Longae, Fructus Ligustri Lucidi 28 parts, the Rhizoma Atractylodis Macrocephalae 8 parts, Herba Artemisiae Scopariae 11 parts, Radix Isatidis 10 parts, Herba Lysimachiae 12 parts, Rhizoma Polygoni Cuspidati 12 parts, Fructus Schisandrae Chinensis 6 parts, 11 parts, Fructus Jujubae;

Preparation method is with embodiment 1.

Application Example two

Embodiment 7 clinical example

Complications after kidney transplantation 32 example wherein routine women 12 example of male 20 is treated altogether from 2002-2014.In 32 routine cases, early stage liver cirrhosis ascites 5 example, the heart failure, edema, hydronephrosis etc. 19 that kidney underactivity toxin expelling dampness removing difference causes is routine, abnormal liver function, and high, the multiple enzyme of bilirubin raises 8 examples.

Efficacy evaluation: divide effective, effective, invalid three kinds.After the tablet has been ingested after January to March, ascites disappears, and heart failure is corrected, and edema disappears, and liver, kidney merit, be clearly better, for effective.In early days in cirrhotic ascites 5 case, effective 4 examples, effective 1 example, invalid is 0.In heart failure edema, hydronephrosis 19 example, effective 16 examples, effective 3 examples, invalid is 0.In the 8 routine cases that the multiple enzyme of abnormal liver function raises, 5 examples are effective, and effectively, invalid 1 is routine for 2 examples.

In 32 cases, effective 25 examples, be 78.12 ‰, effective 6 examples are 18.75 ‰, and invalid 1 example is 3.12 ‰, and total effective rate is more than 96 ‰.

Because of it, there is removing toxic substances removing dampness simultaneously, kidney tonifying hepatoprotective effect, confirm through routine case up to a hundred, this medicine five is taken compared with not medication for (immediately) before drinking or after drinking, 1, same drinking amount is liquor-saturated (taking before drinking) not easily, 2, back of getting up the next morning is not confused not bitterly, in high spirits.

Application Example three model case

Embodiment 8

Liu's ××, man, 69 years old now, doctor.In June, 94 does renal transplantation in Xi'an Jiao great Yi Fu institute, so far Two decades years is had a surplus, after surgery more than a year in, the toxin expelling dampness removing function of kidney is poor, afternoon edema of lower limbs, heart failure, sensation of oppression over the chest with shortness of breath, night can not put down sleeping, kidney district often distending pain can not be belt, blood pressure is at 140-150/95-100mmhg, and dizziness, limbs are trembled, need people to mix on foot holds up, and liver, kidney merit are chemically examined multinomial abnormal.Blood uric acid higher the highest time be 620umol/L, once occur urinary stone once, liver function chemical examination have multiple enzyme to raise, total bilirubin is between 32-38mmol/L, and the red matter of direct gallbladder is between 13-19mmol/L, and blood viscosity is high, each blood test, the blood of 10ml all will connect bundle three ability and take out enough reluctantly.Once took multiple adjuvant therapy medicaments, effect is all undesirable.Start to develop postoperative health care new drug in postoperative Second Year, and try out on one's body, along with adjusting to the right place gradually of medicine composition, clinical various symptom also fades away, and physical recovery is normal.Postoperative 4th year, immunosuppressant was by three-drug therapy.(environmental protection element, azathioprine, hormone) changes bigeminy into, stops using environmental protection element, only with domestic azathioprine and hormone, coordinates and takes this medicine.Except this medicine, expenses for medicine is monthly less than 30 yuan.At present, healthy, liver, the chemical examination of kidney merit, substantially all in normal range, if stop using or reduce this medicine, just there will be brothers' edema, the abnormal conditions such as uncomfortable in chest after a period of time.

Embodiment 9

King ×, female, 45 years old now, Hanzhong City people from Nanzheng County, Shaanxi Province.In April, 2005 just does kidney transfer operation with hospital in Xi'an, postoperative generation acute renal allograft rejection, and through rescuing, heavy dose of Glucocorticoid impact, still has edema though take a favorable turn, heart failure, and the multinomial abnormal bran that is associated with of Liver and kidney merit urinates the situations such as sick.When not having other ways, started to take this medicine in postoperative 3rd month, after taking January, edema disappears, and heart failure is corrected, and liver, kidney merit indices recover gradually, leave hospital and go home to take good care of.So far, Post operation is had a surplus for 9 years, and the indices of liver, kidney merit recovers normal already.

Embodiment 10

Contain ×, man, people from Wuhan City, 45 years old now, Wuhan City taxi driver, did kidney transfer operation in Wuhan City No.1 Hospital in 2003, a postoperative half a year, recovered not good, often had uncomfortable in chest, nervous edema.Start to take this medicine, within 8 years, have a surplus so far, the chemical examination of Liver and kidney merit is all in normal range, and healthy, every day can adhere to normal working.

Embodiment 11

Liu's ××, man, 2002 28 years old, east, Changan District, Xi'an adult.Suffer from more than ten years of nephropathy, after half a year of having dialysed, in June, 2000 has done renal transplantation in Xi'an Jiao great Yi Fu institute, postoperative FK506 and valiant breath, takes the multiple adjuvant drug protecting the liver, protect kidney, blood pressure lowering simultaneously.In October calendar year 2001, substitute MMF with azathioprine, with prednisone, F K506 and azathioprine three-drug therapy.Find after three months that bilirubin raises, indigestion and loss of appetite, abdominal distention, discomfort uncomfortable in chest.In February, 2002, abdominal distention increases the weight of, poor appetite.Daily inspection in April 4, abdomen, distension of jugular vein, under abdominal distension, liver spleen rib can and, 47mm, portal vein 13mm under spleen rib, ascites formed.Maximum fluid level 62mm when lying on the back, pericardium has hydrops.Be diagnosed as: cirrhotic ascites after renal transplantation, companion's pericardial effusion and constrictive pericarditis (being two Grade A hospital diagnostic results), turn the Second Academy of army medical university and do operation on heart.Anuria at that time, take diuretic mixture just can have a small amount of urine, refuse to obey then without.In March, 2002 starts to take this medicine, in order to alleviate the burden of liver.Advise it except the original immunosuppressant used uses as usual, other adjuvant drug comprises diuretic and all stops using, and take medicine second day, urine volume obviously increases.3rd day, abdominal distention alleviated, diet increases, spirit takes a turn for the better, nervous, uncomfortable in chest, obviously alleviated.After two weeks, nervous, disappearance uncomfortable in chest, ascites reduces, and heart is checked, without the necessity of performing an operation again.After one month, because riding motor traumatic injury, wound infection, after using antibiotics, ascites rises again, and inactive antibiotics in a fortnight, recovers again normal gradually.Following the service (this medicine) is after 1 year, and blood pressure reduces to 105/75mmhg, and kidney, liver function are clearly better.Within 2 years, marry afterwards and have a baby born, happy and harmonious.Afterwards, its household waits for information other people slanderous talk, this medicine of stopping using voluntarily when not informing.Have a relapse after half a year, reject, after by transplanted kidney extract, after the several months, Si Yu Merger sends out disease.

Although the present invention describes with reference to specific embodiment as above; but those skilled in the art will be appreciated that; above embodiment is only that the present invention instead of restriction the present invention are described, as long as all should fall in the scope of claims request protection of the application the change of above-described embodiment, modification in spirit of the present invention.

Claims

1. a Post kidney transplantation treatment and health Chinese medicine, comprise active component and adjuvant, counting its active component is by weight: Rhizoma Curcumae Longae 10-18 part, Fructus Ligustri Lucidi 15-30 part, Rhizoma Atractylodis Macrocephalae 6-10 part, Herba Artemisiae Scopariae 10-15 part, Radix Isatidis 8-12 part, Herba Lysimachiae 10-15 part, Rhizoma Polygoni Cuspidati 10-15 part, Fructus Schisandrae Chinensis 5-10 part, Fructus Jujubae 10-15 part.

2. Post kidney transplantation treatment and health Chinese medicine according to claim 1, is characterized in that counting its active component is by weight: 15 parts, Rhizoma Curcumae Longae, Fructus Ligustri Lucidi 20 parts, the Rhizoma Atractylodis Macrocephalae 8 parts, Herba Artemisiae Scopariae 12 parts, Radix Isatidis 10 parts, Herba Lysimachiae 12 parts, Rhizoma Polygoni Cuspidati 12 parts, Fructus Schisandrae Chinensis 8 parts, 12 parts, Fructus Jujubae.

3. Post kidney transplantation treatment and health Chinese medicine according to claim 1 and 2, is characterized in that: described Chinese medicine composition makes tablet, granule or capsule.

4. Post kidney transplantation treatment and health Chinese medicine according to claim 3, is characterized in that: described Chinese medicine composition makes capsule.

5. Post kidney transplantation treatment and health Chinese medicine according to claim 4, is characterised in that its preparation method comprises the steps:

1) by weight proportion, by above crude drug decoction pieces, well sifted remove impurity is for subsequent use; 2) beat powder after getting Rhizoma Curcumae Longae, the Rhizoma Atractylodis Macrocephalae, Radix Isatidis, three kinds of medicine mixing in proportion, cross 80 mesh sieves, obtain fine powder, for subsequent use; 3) all the other flavour of a drug soak four hours, and the adjustment water yield there was not medicine 4-5cm, and normal pressure decocts three times, often all over two hours, merges medicinal liquid, be condensed into cream after filtration; 4) add above medicated powder, mix well, the dry rear pulverizing of the universe, cross 14 mesh sieves, make granule coarse powder, fill No. 0 capsule and get final product.