CN102743584B - Traditional Chinese medicine for decreasing blood sugar and preparation method thereof - Google Patents
Traditional Chinese medicine for decreasing blood sugar and preparation method thereof Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine for decreasing blood sugar and a preparation method thereof. Active pharmaceutical ingredients of the traditional Chinese medicine for decreasing the blood sugar comprises extracts and 10-12 parts by weight of buck wheat flour, wherein the extracts are extracted by water decocting or alcohol refluxing a mixture of 45-55 parts by weight of astragalus, 28-32 parts by weight of polygonatum, 28-32 parts by weight of polygonatum odoratum, 38-42 parts by weight of cortex lycii radicis, 18-22 parts by weight of rhizoma dioscoreae and 18-22 parts by weight of rhizoma alismatis. The preparation method comprises the steps of mixing astragalus, polygonatum, polygonatum odoratum, cortex lycii radicis, rhizoma dioscoreae and rhizoma alismatis, adding water into the mixture and decocting, concentrating a drug solution to obtain an extract, or extracting by alcohol reflux, concentrating a drug solution to obtain an extract; and mixing the extract obtained from one of the above method and buck wheat flour to obtain the traditional Chinese medicine for decreasing the blood sugar. The traditional Chinese medicine for decreasing the blood sugar has the beneficial effects of providing novel traditional Chinese medicine species effective in treatment for treating hyperglycemia diseases.
Description
Technical field
The invention belongs to field of medicaments, be specifically related to a kind of hypoglycemic Chinese medicine.
Background technology
Before this, had several hypoglycemic Chinese patent medicines to use in hyperglycemia population, but have no therapeutic effect comparatively outstanding, can be by comparatively universally recognized kind.
Summary of the invention
The object of this invention is to provide a kind of hypoglycemic Chinese medicine and preparation method, for treatment hyperglycemia disease provides new herbal species, to improving the curative effect of Chinese medicine in treatment hyperglycemia.
Antidiabetic drug of the present invention: after being mixed by Radix Astragali 45-55 weight portion, Rhizoma Polygonati 28-32 weight portion, Rhizoma Polygonati Odorati 28-32 weight portion, Cortex Lycii 38-42 weight portion, Rhizoma Dioscoreae 18-22 weight portion, Rhizoma Alismatis 18-22 weight portion, extract and the Radix Et Rhizoma Fagopyri Tatarici powder 10-12 weight portion of water boiling and extraction or alcohol reflux form medicinal active ingredient.
The best medical material usage ratio of antidiabetic drug of the present invention is: the Radix Astragali 50 weight portions, Rhizoma Polygonati 30 weight portions, Rhizoma Polygonati Odorati 30 weight portions, Cortex Lycii 40 weight portions, Rhizoma Dioscoreae 20 weight portions, Rhizoma Alismatis 20 weight portions, Radix Et Rhizoma Fagopyri Tatarici 11 weight portions.
Preparation method of the present invention comprises:
Method 1
(1) get Radix Astragali 45-55 weight portion, Rhizoma Polygonati 28-32 weight portion, Rhizoma Polygonati Odorati 28-32 weight portion, Cortex Lycii 38-42 weight portion, Rhizoma Dioscoreae 18-22 weight portion, Rhizoma Alismatis 18-22 weight portion, Radix Et Rhizoma Fagopyri Tatarici 10-12 weight portion;
(2) step (1) Radix Astragali of getting, Rhizoma Polygonati, Rhizoma Polygonati Odorati, Cortex Lycii, Rhizoma Dioscoreae, Rhizoma Alismatis are mixed, add 8 times of water soaking 1h of medical material weight, then decoct 2h, filter filtrate for later use;
(3) medicinal residues that step (2) leached add the water with step (2) equivalent again, then decoct 2h, filter, and obtain filtrate;
(4) combining step (2), (3) gained filtrate, quiescent setting 6h, gets supernatant centrifugal treating;
(5) medicinal liquid of processing through step (4) is evaporated under 70-80 ℃, 0.075-0.085Mpa condition to the thick extractum of 60 ℃ of lower density 120-130;
(6) use Co 60 with the sterilizing of 5kgy amount of radiation step (1) Radix Et Rhizoma Fagopyri Tatarici of getting;
(7) Radix Et Rhizoma Fagopyri Tatarici powder through step (6) sterilizing is broken into 80-100 object fine powder;
(8) the thick extractum of step (5) gained is mixed with the Radix Et Rhizoma Fagopyri Tatarici powder of step (7) gained, concentrating under reduced pressure under 70-80 ℃, 0.075-0.085Mpa condition, obtains dry extract shape blood-sugar lowering tcm drug;
(9) step (8) gained dry extract is broken into extract powder and mixes with dextrine powder 1.5 weight portions, encapsulated, obtain blood-sugar lowering tcm drug capsule of the present invention, or by extract powder and other conventional pharmaceutical carrier or mixed with excipients, make conventional peroral dosage form.
Method 2
(1) get Radix Astragali 45-55 weight portion, Rhizoma Polygonati 28-32 weight portion, Rhizoma Polygonati Odorati 28-32 weight portion, Cortex Lycii 38-42 weight portion, Rhizoma Dioscoreae 18-22 weight portion, Rhizoma Alismatis 18-22 weight portion, Radix Et Rhizoma Fagopyri Tatarici 10-12 weight portion;
(2) step (1) Radix Astragali of getting, Rhizoma Polygonati, Rhizoma Polygonati Odorati, Cortex Lycii, Rhizoma Dioscoreae, Rhizoma Alismatis are mixed, add medical material weight 10-20 doubly, the concentration alcohol reflux that is 50～90% 2～4 times, each time is 0.5～3h, reclaim ethanol, merge extractive liquid, is evaporated to extracting solution the thick extractum of 60 ℃ of lower density 1.20-1.30 under 70-80 ℃, 0.075-0.085Mpa condition;
(3) use Co 60 with the sterilizing of 5kgy amount of radiation step (1) Radix Et Rhizoma Fagopyri Tatarici of getting;
(4) Radix Et Rhizoma Fagopyri Tatarici powder through step (3) sterilizing is broken into 80-100 object fine powder;
(5) the thick extractum of step (2) gained is mixed with the Radix Et Rhizoma Fagopyri Tatarici powder of step (4) gained, concentrating under reduced pressure under 70-80 ℃, 0.075-0.085Mpa condition, obtains dry extract shape blood-sugar lowering tcm drug;
(6) step (5) gained dry extract is broken into extract powder and mixes with dextrine powder 1.5 weight portions, encapsulated, obtain blood-sugar lowering tcm drug capsule of the present invention, or by extract powder and other conventional pharmaceutical carrier or mixed with excipients, make conventional peroral dosage form.
Instructions of taking and consumption: oral, every day 2 times, each 1.2-1.5g.
The invention has the beneficial effects as follows: take the Radix Astragali, Rhizoma Polygonati is principal agent, can benefiting QI for strengthening the superficies, YIN nourishing and the production of body fluid promoting is monarch; Take Rhizoma Polygonati Odorati, Cortex Lycii is minister, assists nourishing YIN to relieve dryness, promoting the production of body fluid to quench thirst; Rhizoma Dioscoreae, Rhizoma Alismatis strengthening spleen, tonifying kidney, promoting diuresis with drugs of tasteless flavour for assistant, make body fluid You Zishengzhi source; Less with Radix Et Rhizoma Fagopyri Tatarici for making, physical strength profiting, continuous spirit, sharp knowledge, have the wide intestinal digestion promoting function of sending down the abnormal ascending QI.All raw materials share common tune and mend internal organs, from QI invigorating kidney tonifying, nourishing YIN and clearing away heat, and then reach auxiliary hyperglycemic, for treatment hyperglycemia disease provides Chinese medicine new varieties evident in efficacy.
Compliance test result
Using the Chinese medicine of the present invention of capsule formulation as test medication, in test, claim in " Chinese medicine of the present invention ".
one, the impact of Chinese medicine of the present invention on epinephrine type hyperglycemic rat blood sugar level
Get 60 of healthy male rats, be divided at random 6 groups. 10 every group.Be respectively Normal group, model group, the high, medium and low dosage of Chinese medicine of the present invention (0.50,0.25,0.13g/kg) group, ginseng stilbene Chinese medicine of the present invention (0.5g/kg) group.All, by the volume gastric infusion of 1ml/100g body weight, Normal group and model group give distilled water.Every day 1 time, continuously 15d.Before last administration, water 12d is can't help in fasting, 1.5h after last administration, and except Normal group, each organizes equal lumbar injection epinephrine 0.5mg/kg, and while gavage glucose solution 1g/kg, to strengthen modeling.Respectively at after modeling 1,2,3h surveys blood sugar content on an empty stomach, all takes determination of glucose oxidase serum glucose level.The results are shown in Table 1.
Result shows, Chinese drug-treated group of the present invention can obviously reduce epinephrine type hyperglycemic rat blood sugar level, remarkable with model group comparing difference.
two, the impact of Chinese medicine of the present invention on alloxan type hyperglycemic rat blood glucose, insulin level
choose 70 of healthy rats, water 12h is can't help in fasting, and 72h after ip alloxan 160mg/kg cuts tail blood sampling and measures blood glucose.By 20 higher and lower rejectings of blood glucose in modeling rat, select 40 of the approaching hyperglycemic rats of blood sugar level (blood glucose value 16-21mmol/L).Be divided at random 5 groups, 10 every group.Be respectively model control group, the large, medium and small dosage of Chinese medicine of the present invention (0.5,2.5,1.3g/kg) group, SHENQI JIANGTANG glue (0.4g/kg) group, separately gets 10 of healthy rats and makes Normal group, and gastric infusion method is the same.Before last administration, water 12h is can't help in fasting, and after last administration, 1.5h cuts tail blood sampling, determination of glucose oxidase blood glucose, and radiation epidemic disease method is measured insulin level, the results are shown in Table 2.
Result shows, Chinese drug-treated group of the present invention can obviously reduce alloxan type hyperglycemic rat blood sugar level, improves insulin level, remarkable with model group comparing difference.
Three,
the impact of Chinese medicine of the present invention on the little blood sugar content of normal mice
?get 50 of mices, male and female half and half, are divided into 5 groups at random. and 10 every group.Be respectively Normal group, Chinese medicine of the present invention high, medium and low (0.64,0.32,0.16 g/kg) group, ginseng stilbene Chinese medicine of the present invention (0.6 g/kg).Normal group steams water, and all the other respectively organize equal gastric infusion, and capacity is 0.1ml/kg, every day 1 time, continuously 15d.Before last administration, water 12d is can't help in fasting, 1.5h after last administration, and vena ophthalmica clump is got blood, adopts determination of glucose oxidase serum glucose level.The results are shown in Table 3
Result shows that Chinese drug-treated group of the present invention has no significant effect normal mouse blood sugar.
Four,
the impact of Chinese medicine of the present invention on glucose tolerance
get 50 of mices, grouping is with experiment three.All the other respectively organize equal gastric infusion, and capacity is 0.2ml/kg, and Normal group steams water.Every day 1 time, continuously 15d.Water 12d is can't help in fasting before last administration, 1.5h after last administration, and each organizes gavage glucose solution 2g/kg, respectively at 0,0.5,1,2h vena ophthalmica clump gets blood, measures blood sugar level.The results are shown in Table 4.
Result shows that Chinese drug-treated group of the present invention has no significant effect normal mouse blood sugar tolerance.
The specific embodiment
1 gets Radix Astragali 500g, Rhizoma Polygonati 300g, Rhizoma Polygonati Odorati 300g, Cortex Lycii 400g, Rhizoma Dioscoreae 200g, Rhizoma Alismatis 200g, Radix Et Rhizoma Fagopyri Tatarici 110g, dextrin 15g;
2, by the Radix Astragali that step 1 is got,, Rhizoma Polygonati,, Rhizoma Polygonati Odorati,, Cortex Lycii,, Rhizoma Dioscoreae,, Rhizoma Alismatis mixes, and adds 8 times of water soaking 1h of medical material weight, then decocts 2h, filters filtrate for later use;
3, the medicinal residues that step 2 leached add the water with step 2 equivalent again, then decoct 2h, filter, and obtain filtrate;
4, combining step 2,3 gained filtrates, quiescent setting 6h, gets supernatant centrifugal treating;
5, the medicinal liquid of processing through step 4 is evaporated under 70-80 ℃, 0.075-0.085Mpa condition to the thick extractum of 60 ℃ of lower density 120-130;
6, use Co 60 with the sterilizing of 5kgy amount of radiation Radix Et Rhizoma Fagopyri Tatarici that step 1 is got;
7, the Radix Et Rhizoma Fagopyri Tatarici powder through step 6 sterilizing is broken into 80-100 object fine powder;
8, the thick extractum of step 5 gained is mixed with the Radix Et Rhizoma Fagopyri Tatarici powder of step 7 gained, concentrating under reduced pressure under 70-80 ℃, 0.075-0.085Mpa condition, obtains dry extract shape blood-sugar lowering tcm drug;
9, step 8 gained dry extract is broken into extract powder and mixes with dextrine powder, divide and be filled in 1000 capsules, in every capsules, powder charge 0.45g obtains blood-sugar lowering tcm drug capsule of the present invention.
Claims (4)
1. a hypoglycemic Chinese medicine, is characterized in that: after being mixed by Radix Astragali 45-55 weight portion, Rhizoma Polygonati 28-32 weight portion, Rhizoma Polygonati Odorati 28-32 weight portion, Cortex Lycii 38-42 weight portion, Rhizoma Dioscoreae 18-22 weight portion, Rhizoma Alismatis 18-22 weight portion, extract and the Radix Et Rhizoma Fagopyri Tatarici powder 10-12 weight portion of water boiling and extraction or alcohol reflux form medicinal active ingredient.
2. a kind of hypoglycemic Chinese medicine according to claim 1, is characterized in that medical material usage ratio is: the Radix Astragali 50 weight portions, Rhizoma Polygonati 30 weight portions, Rhizoma Polygonati Odorati 30 weight portions, Cortex Lycii 40 weight portions, Rhizoma Dioscoreae 20 weight portions, Rhizoma Alismatis 20 weight portions, Radix Et Rhizoma Fagopyri Tatarici 11 weight portions.
3. a preparation method for blood sugar lowering Chinese medicine, comprises the following steps
(1) get Radix Astragali 45-55 weight portion, Rhizoma Polygonati 28-32 weight portion, Rhizoma Polygonati Odorati 28-32 weight portion, Cortex Lycii 38-42 weight portion, Rhizoma Dioscoreae 18-22 weight portion, Rhizoma Alismatis 18-22 weight portion, Radix Et Rhizoma Fagopyri Tatarici 10-12 weight portion;
(2) step (1) Radix Astragali of getting, Rhizoma Polygonati, Rhizoma Polygonati Odorati, Cortex Lycii, Rhizoma Dioscoreae, Rhizoma Alismatis are mixed, add 8 times of water soaking 1h of medical material weight, then decoct 2h, filter filtrate for later use;
(3) medicinal residues that step (2) leached add the water with step (2) equivalent again, then decoct 2h, filter, and obtain filtrate;
(4) combining step (2), (3) gained filtrate, quiescent setting 6h, gets supernatant centrifugal treating;
(5) medicinal liquid of processing through step (4) is evaporated under 70-80 ℃, 0.075-0.085Mpa condition to the thick extractum of 60 ℃ of lower density 1.20-1.30;
(6) use Co 60 with the sterilizing of 5kgy amount of radiation step (1) Radix Et Rhizoma Fagopyri Tatarici of getting;
(7) Radix Et Rhizoma Fagopyri Tatarici powder through step (6) sterilizing is broken into 80-100 object fine powder;
(8) the thick extractum of step (5) gained is mixed with the Radix Et Rhizoma Fagopyri Tatarici powder of step (7) gained, concentrating under reduced pressure under 70-80 ℃, 0.075-0.085Mpa condition, obtains dry extract shape blood-sugar lowering tcm drug;
(9) step (8) gained dry extract is broken into extract powder and mixes with dextrine powder 1.5 weight portions, encapsulated, obtain blood-sugar lowering tcm drug capsule, or by extract powder and other conventional pharmaceutical carrier or mixed with excipients, make conventional peroral dosage form.
4. a preparation method for blood sugar lowering Chinese medicine, comprises the following steps
(1) get Radix Astragali 45-55 weight portion, Rhizoma Polygonati 28-32 weight portion, Rhizoma Polygonati Odorati 28-32 weight portion, Cortex Lycii 38-42 weight portion, Rhizoma Dioscoreae 18-22 weight portion, Rhizoma Alismatis 18-22 weight portion, Radix Et Rhizoma Fagopyri Tatarici 10-12 weight portion;
(2) step (1) Radix Astragali of getting, Rhizoma Polygonati, Rhizoma Polygonati Odorati, Cortex Lycii, Rhizoma Dioscoreae, Rhizoma Alismatis are mixed, add medical material weight 10-20 doubly, the concentration alcohol reflux that is 50～90% 2～4 times, each time is 0.5～3h, reclaim ethanol, merge extractive liquid, is evaporated to extracting solution the thick extractum of 60 ℃ of lower density 1.20-1.30 under 70-80 ℃, 0.075-0.085Mpa condition;
(3) use Co 60 with the sterilizing of 5kgy amount of radiation step (1) Radix Et Rhizoma Fagopyri Tatarici of getting;
(4) Radix Et Rhizoma Fagopyri Tatarici powder through step (3) sterilizing is broken into 80-100 object fine powder;
(5) the thick extractum of step (2) gained is mixed with the Radix Et Rhizoma Fagopyri Tatarici powder of step (4) gained, concentrating under reduced pressure under 70-80 ℃, 0.075-0.085Mpa condition, obtains dry extract shape blood-sugar lowering tcm drug;
(6) step (5) gained dry extract is broken into extract powder and mixes with dextrine powder 1.5 weight portions, encapsulated, obtain blood-sugar lowering tcm drug capsule, or by extract powder and other conventional pharmaceutical carrier or mixed with excipients, make conventional peroral dosage form.
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| CN103315221A (en) * | 2013-05-30 | 2013-09-25 | 宁国市亿邦生物科技有限公司 | Instant powder having auxiliary blood sugar-reduction effect and preparation method thereof |
| CN104083578A (en) * | 2014-07-14 | 2014-10-08 | 上海浦东高星生物技术研究所 | Chinese patent medicine for promoting urination and reducing blood sugar |
| CN105685754A (en) * | 2016-01-20 | 2016-06-22 | 哈尔滨瑞烨环保科技有限公司 | Inonotuso bliquus pilat compound solid beverage as well as preparation method and application thereof |
| CN105918572A (en) * | 2016-06-23 | 2016-09-07 | 冯世英 | Brewing bag type blood glucose lowering tea |
| CN108523129A (en) * | 2018-05-14 | 2018-09-14 | 珠海联邦制药股份有限公司 | A kind of auxiliary hyperglycemic composition and preparation method thereof |
Citations (3)
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| CN1650990A (en) * | 2004-12-16 | 2005-08-10 | 贺国政 | Chinese medicine for treating diabetes |
| CN101134083A (en) * | 2007-09-18 | 2008-03-05 | 王平 | Chinese medicinal herb capsule for treating diabetes and its complication and method for preparing the same |
| CN101433597A (en) * | 2007-11-16 | 2009-05-20 | 北京因科瑞斯医药科技有限公司 | Chinese medicinal composition with function for reducing blood sugar and preparation method thereof |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1650990A (en) * | 2004-12-16 | 2005-08-10 | 贺国政 | Chinese medicine for treating diabetes |
| CN101134083A (en) * | 2007-09-18 | 2008-03-05 | 王平 | Chinese medicinal herb capsule for treating diabetes and its complication and method for preparing the same |
| CN101433597A (en) * | 2007-11-16 | 2009-05-20 | 北京因科瑞斯医药科技有限公司 | Chinese medicinal composition with function for reducing blood sugar and preparation method thereof |
Non-Patent Citations (2)
| Title |
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| 中医药治疗2型糖尿病的研究进展;朱志远等;《四川中医》;20110515;第29卷(第5期);第48-51页 * |
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