CN101480472B - Medicament for reducing blood pressure and regulating blood fat and production method - Google Patents
Medicament for reducing blood pressure and regulating blood fat and production method Download PDFInfo
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- CN101480472B CN101480472B CN2008100728032A CN200810072803A CN101480472B CN 101480472 B CN101480472 B CN 101480472B CN 2008100728032 A CN2008100728032 A CN 2008100728032A CN 200810072803 A CN200810072803 A CN 200810072803A CN 101480472 B CN101480472 B CN 101480472B
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Abstract
The invention discloses a medicament for lowering blood pressure and regulating blood lipid and a preparation method of the medicament. The medicament is mainly prepared by using 0.5 to 8 portions of sophora alopecuroide, 10 to 35 portions of cassia seed, 10 to 35 portions of hawthorn, 8 to 30 portions of radix pseudostell, 3 to 25 portions of rhizoma gastrodiae used as raw material through alcohol extraction, water extraction, preparation forming and the like. The medicament has the advantages of convenience for carrying and convenience for oral administration and is favorable to the long-term oral administration and the effective control of patient's conditions. In the preparation method, different medicinal materials are processed through the alcohol extraction or the water extraction respectively, thus the effective components can be fully extracted and utilized.
Description
Technical field
The present invention relates to a kind of medicine and production method of transferring blood fat.
Background technology
Hyperlipidemia is the healthy common frdquently encountered disease of a kind of harm humans, also is a kind of disease of very difficult healing.Be western medical treatment to the most direct efficacious therapy of hyperlipemia both at home and abroad at present, but use Western medicine merely, be prone to cause hepatorenal damage, gastrointestinal reaction and other side reaction.The domestic report that many Chinese medicine hyperlipemias are also arranged, clinical research show that Chinese medicine can improve function, corrects dysequilibrium, relief of symptoms, consolidate curative effect, is characterized in that the Chinese herbal medicine property of medicine is pure and gentle; Side effect is less, but existing Chinese medicinal formulae one is owing to the side's of choosing reason, and the 2nd, application method mainly is to fry in shallow oil into decoction to take; Medication inconvenience; Can not form the production of scale property ground, often make patient be difficult to adhere to that long-term stability takes effectively, influence curative effect to a certain extent.
Summary of the invention
The purpose of patent of the present invention is that toxic and side effects is little, therapeutic effect good and the medicine and the production method of the accent blood fat of taking convenience.
Drug main of the present invention will be produced by the medical material of following weight proportion: 0.5～8 part of Herba Sophorae alopecuroidis, 10～35 parts of Semen Cassiaes, 10～35 parts of Fructus Crataegis, 8～30 parts of Radix Pseudostellariaes, 3～25 parts in Rhizoma Gastrodiae.
The preferred version of above-mentioned medical material is: 0.5～2.5 part of Herba Sophorae alopecuroidis, 22～35 parts of Semen Cassiaes, 22～35 parts of Fructus Crataegis, 10～25 parts of Radix Pseudostellariaes, 3～18 parts in Rhizoma Gastrodiae.
As further improved plan, when producing, above-mentioned medicine preferably adds in the following medicinal materials one or more:
8～30 parts of the Radixs Astragali, 6～25 parts of Herb Gynostemmae Pentaphylli, 8～30 parts of Radix Codonopsis, Radix Glycyrrhizae 1～15,4～25 parts of Radix Scutellariaes, 4～25 parts of Semen Raphanis.It is preferably: 16～25 parts of the Radixs Astragali, 6～15 parts of Herb Gynostemmae Pentaphylli, 16～25 parts of Radix Codonopsis, 1.5～10 parts in Radix Glycyrrhizae, 5～20 parts of Radix Scutellariaes, 12～20 parts of Semen Raphanis.
The production method of said medicine is following:
Alcohol extraction:
Take by weighing Semen Cassiae, Fructus Crataegi, be crushed to below the granularity 5mm by proportioning; Add 6～24 times of 35～95% ethanol by weight as solvent; Reflux, extract, 2～6 times; Each 15～360 minutes, mistake≤250 μ m sieve extract, be evaporated to every 1ml with Rotary Evaporators and contain primary medicine 0.2～4g and get the concentrated solution I;
Also can add Herb Gynostemmae Pentaphylli in the medical material of above-mentioned alcohol extraction.
Water is carried:
Take by weighing Herba Sophorae alopecuroidis, Radix Pseudostellariae, Rhizoma Gastrodiae by proportioning, be crushed to below the granularity 5mm, add 5～30 times of water by weight, decoct 1～5 time at 85～110 ℃; The each decoction 15～300 minutes, mistake≤250 μ m sieve extract, be concentrated into every 1ml and contain primary medicine 0.2～4g; Add 35～95% ethanol then, make medicinal liquid contain the alcohol amount and reach 50～90%, placed 6～48 hours; Filter, decompression filtrate recycling ethanol contains primary medicine 0.2～4g to every 1ml and gets the concentrated solution II, and is subsequent use.
Also can add in the Radix Astragali, Semen Raphani, Radix Glycyrrhizae, Radix Scutellariae, Rhizoma Gastrodiae, the Herb Gynostemmae Pentaphylli one or more in the medical material that above-mentioned water is carried.
Become the preparation of agent:
With above-mentioned alcohol extraction and water carry gained concentrated solution I and concentrated solution II filtrating merge extractum; In selection sucrose, dextrin, starch or the mannitol one or more are pressed arbitrary proportion and are mixed as diluent; Press the ratio mixing granulation of extractum and diluent 1:1.5～8; Intensive drying to water content≤10% in baking oven below 80 ℃ promptly obtains medicine of the present invention.
Above-mentioned diluent is preferably mannitol or starch.
As improved technical scheme, above-mentioned alcohol extraction and water are carried and can be supersound extraction:
Alcohol extraction: 300～1000 kilo hertzs of following alcohol extractions of supersonic frequency 10～180 minutes.
Water is carried: carry 10～180 minutes at 300～1000 kilo hertzs of following water of supersonic frequency.
The studies on acute toxicity of pharmaceutical preparation of the present invention: 60 of Kunming mouses, male and female half and half are divided into 6 groups at random, and the experiment prospective adaptation fed for 1 week, observed each mice health status.Water is can't help in 12h fasting before the administration, the drug extract of the present invention of 1,2,3 group of white mice filling clothes variable concentrations 1 time; 4,5 groups of white mice are irritated the drug extract of the present invention 2 times of clothes variable concentrations, and be 4h twice blanking time, and dosage is than being 1:0.75 between group; 6 groups of white mice are irritated the clothes normal saline; Freely drink water after the administration, every day at the upper and lower noon respectively observes 2 times, observes continuously 7 days.The result sees table 1
Table 1 mouse stomach drug extract maximum tolerated dose of the present invention
| Group | Mus is counted n | Medicine | Dosage mL/10g.d | Death toll n |
| 1 | 10 | Drug extract of the present invention | 0.19 | 0 |
| 2 | 10 | Drug extract of the present invention | 0.26 | 0 |
| 3 | 10 | Drug extract of the present invention | 0.35 | 0 |
| 4 | 10 | Drug extract of the present invention | 0.46 | 0 |
| 5 | 10 | Drug extract of the present invention | 0.61 | 2 |
| 6 | 10 | Normal saline | 0.61 | 0 |
The result shows that mouse stomach maximum tolerated dose dosage is 0.46mL/10g.d; Drug level is 5.4g/mL, and promptly 248.4g/kg.d is 81g with the 1d consumption of being grown up; Average weight is that 60kg calculates, and the maximum tolerated dose of mice is 184 times of the daily dosage of the clinical plan of adult.
Carrying out on the white mice acute toxicity testing basis, selecting 50 routine hyperlipidemia patients to carry out clinical research, observing influence, for thoroughly evaluating medicine of the present invention is transferred blood fat the hyperlipidemia patient lipid metabolism.
Case is selected from the outpatient of First Affiliated Hospital, Shihezi University College of Medicine, totally 50 examples, male 28 people, women 22 people, 34～68 years old age.Patient's course of disease is the shortest 1 year, year, wherein 5 routine complicated hypertensions surplus in the of the longest 10.Preceding 1 week of patient's medication, two groups of medicines of all stopping using the blood fat reducing Chinese medicine and western medicine and influencing hemorheological property, dietary structure is constant.
The treatment group gives the identical medical material prescription of the present invention decocting, divides and takes for 2 times, 1 dose of every day.
Matched group gives the identical medical material of the present invention made medicament capsule of filling a prescription, each 0.4g, every day 2 times.
Two groups all per 4 all further consultations are once write down the variation of blood fat, symptom, sign, continuous 12 weeks.
Experimental result is seen table 2-1,2-2
Two groups of clinical efficacies of table 2-1 are (%) relatively
| Group | n | Clinic control | Produce effects | Effectively | Invalid | Total effective rate |
| The treatment group | 30 | 8(26.7) | 15(50.0) | 3(10.0) | 4(13.3) | 86.7 |
| Matched group | 20 | 5(25.0) | 12(60.0) | 1(5.0) | 2(10.0) | 90.0 |
TC, TG, LDL-C and HDL-C change relatively (x ± s, mmolL before and after two groups of treatments of table 2-2
-1)
| ? | n | Time | TC | TG | LDL-C | HDL-C |
| The treatment group | 30 | Before the medicine | 6.66±1.36 | 3.89±3.20 | 2.74±1.10 | 1.55±0.37 |
| ? | ? | 4 weeks of medication | 5.14±3.16 | 3.17±2.84 | 2.48±1.10 | 1.46±0.35 |
| ? | ? | 8 weeks of medication | 5.05±2.98** | 2.73±1.68 | 2.15±0.77** | 1.48±0.32 |
| ? | ? | 12 weeks of medication | 4.70±2.27** | 2.59±2.03* | 2.10±0.84* | 2.88±0.90** |
| Matched group | 20 | Before the medicine | 6.47±0.96 | 3.78±2.78 | 3.02±0.90 | 1.43±0.42 |
| ? | ? | 4 weeks of medication | 4.79±0.94** | 2.82±1.32 | 2.73±0.74 | 1.48±0.20 |
| ? | ? | 8 weeks of medication | 4.71±1.03** | 2.44±0.83* | 2.23±0.69** | 1.61±0.36 |
| ? | ? | 12 weeks of medication | 4.22±1.26** | 2.35±1.31* | 2.31±0.58** | 1.93±0.96**^^ |
Annotate: with comparing * before the medicine is that < 0.05, * * is P < 0.01 to P; With matched group comparison ^^ be P < 0.01.
The result shows total effective rate 86.7%; 90.0%, two group of total effective rate of matched group total effective rate relatively, difference does not have significance (P>0.05); The treatment group can significantly reduce plasma TC, TG, LDL (P < 0.01), rising HDL (P 0.01).
Medicine of the present invention is described and is had identical curative effect with square Chinese medicine decoction agent; All can obviously improve blood fat disorder patient's situation; Especially medicine of the present invention also have can carry, the advantage of taking convenience, help taking for a long time, effective control conditions of patients is highly profitable; On preparation method, take alcohol extraction or extraction process by water respectively, make effective ingredient be able to abundant extraction and application to different medical materials.
The specific embodiment
Embodiment 1:
Get 8 parts of Herba Sophorae alopecuroidiss by weight, 10 parts of Semen Cassiaes, 15 parts of Fructus Crataegis, 10 parts of Radix Pseudostellariaes, 8 parts in Rhizoma Gastrodiae, 20 parts of the Radixs Astragali, 25 parts of Herb Gynostemmae Pentaphylli.
With Semen Cassiae, Fructus Crataegi, the Herb Gynostemmae Pentaphylli mixed powder is broken to below the granularity 2mm, adds 15 times of 70% ethanol by weight as solvent; Reflux, extract, 3 times; Each 180 minutes, cross 250 μ m sieve extract, be evaporated to every 1ml with Rotary Evaporators and contain primary medicine 3g and get the concentrated solution I;
Herba Sophorae alopecuroidis, Rhizoma Gastrodiae, Radix Pseudostellariae, Radix Astragali mixed powder are broken to below the granularity 5mm, add 30 times of water by weight, decoct 3 times down at 98 ℃; The each decoction 60 minutes, cross 250 μ m sieve extract, adopt the low-voltage vacuum method to be concentrated into every 1ml and contain primary medicine 3g; Add 70% ethanol then, make medicinal liquid contain the alcohol amount and reach 80%, placed 24 hours; Filter with 150 μ m sieve, decompression filtrate recycling ethanol contains primary medicine 3g to every 1ml and gets the concentrated solution II, and is subsequent use.
With above-mentioned alcohol extraction and water carry gained concentrated solution I and concentrated solution II filtrating merge extractum; With the starch of 1:1 proportioning and mannitol mixture as diluent; Press the ratio mixing granulation of extractum and diluent 1:3; Intensive drying to water content≤7% in baking oven below 80 ℃ promptly obtains medicine of the present invention.
Embodiment 2:
Get 4 parts of Herba Sophorae alopecuroidiss by weight, 18 parts of Semen Cassiaes, 10 parts of Fructus Crataegis, 25 parts of Radix Pseudostellariaes, 20 parts in Rhizoma Gastrodiae, 25 parts of the Radixs Astragali, 20 parts of Herb Gynostemmae Pentaphylli, 10 parts in Radix Glycyrrhizae, 5 parts of Radix Scutellariaes.
With Semen Cassiae, Fructus Crataegi, Rhizoma Gastrodiae, Herb Gynostemmae Pentaphylli mixed powder are broken to below the granularity 1mm, add 15 times of 85% ethanol by weight as solvent; Reflux, extract, 4 times; Each 240 minutes, cross 150 μ m sieve extract, be evaporated to every 1ml with Rotary Evaporators and contain primary medicine 2g and get the concentrated solution I;
Herba Sophorae alopecuroidis, the Radix Astragali, Radix Pseudostellariae, Radix Glycyrrhizae, Radix Scutellariae mixed powder are broken to below the granularity 3mm, add 20 times of water by weight, decoct 4 times down at 100 ℃; The each decoction 40 minutes, cross 150 μ m sieve extract, adopt the low-voltage vacuum method to be concentrated into every 1ml and contain primary medicine 3g; Add 85% ethanol then, make medicinal liquid contain the alcohol amount and reach 80%, placed 48 hours; Filter with 150 μ m sieve, decompression filtrate recycling ethanol contains primary medicine 2g to every 1ml and gets the concentrated solution II, and is subsequent use.
With above-mentioned alcohol extraction and water carry gained concentrated solution I and concentrated solution II filtrating merge extractum, as diluent, press the ratio mixing granulation of extractum and diluent 1:5 with starch, intensive drying to water content≤5% in baking oven below 80 ℃ promptly obtains medicine of the present invention.
Embodiment 3:
Get 6 parts of Herba Sophorae alopecuroidiss by weight, 25 parts of Semen Cassiaes, 18 parts of Fructus Crataegis, 20 parts of Radix Pseudostellariaes, 5 parts in Rhizoma Gastrodiae, 10 parts of the Radixs Astragali, 15 parts of Herb Gynostemmae Pentaphylli, 2 parts in Radix Glycyrrhizae, 10 parts of Radix Scutellariaes.
Semen Cassiae, Fructus Crataegi, Rhizoma Gastrodiae, Herb Gynostemmae Pentaphylli mixed powder are broken to below the granularity 1mm; Add 15 times of 85% ethanol by weight as solvent, reflux, extract, 4 times, each 240 minutes; Cross 150 μ m sieve extract, be evaporated to every 1ml with Rotary Evaporators and contain primary medicine 2g and get the concentrated solution I;
Herba Sophorae alopecuroidis, the Radix Astragali, Radix Pseudostellariae, Radix Glycyrrhizae, Radix Scutellariae mixed powder are broken to below the granularity 3mm, add 20 times of water by weight, decoct 4 times down at 100 ℃; The each decoction 40 minutes, cross 150 μ m sieve extract, adopt the low-voltage vacuum method to be concentrated into every 1ml and contain primary medicine 3g; Add 85% ethanol then, make medicinal liquid contain the alcohol amount and reach 80%, placed 48 hours; Filter with 150 μ m sieve, decompression filtrate recycling ethanol contains primary medicine 2g to every 1ml and gets the concentrated solution II, and is subsequent use.
With above-mentioned alcohol extraction and water carry gained concentrated solution I and concentrated solution II merge extractum, as diluent, press the ratio mixing granulation of extractum and diluent 1:5 with starch, intensive drying to water content≤5% in baking oven below 80 ℃ promptly obtains medicine of the present invention.
Embodiment 4:
Get 6 parts of Herba Sophorae alopecuroidiss by weight, 18 parts of Semen Cassiaes, 10 parts of Fructus Crataegis, 25 parts of Radix Pseudostellariaes, 20 parts in Rhizoma Gastrodiae, 25 parts of the Radixs Astragali, 25 parts of Herb Gynostemmae Pentaphylli, 10 parts in Radix Glycyrrhizae, 5 parts of Radix Scutellariaes, 15 parts of Semen Raphanis.
Semen Cassiae, Fructus Crataegi mixed powder are broken to below the granularity 1mm, add 18 times of 90% ethanol by weight as solvent, reflux, extract, 3 times, each 210 minutes, cross 125 μ m sieve extract, be evaporated to every 1ml and contain primary medicine 1g and get the concentrated solution I;
Herba Sophorae alopecuroidis, the Radix Astragali, Radix Glycyrrhizae, Radix Pseudostellariae, Radix Scutellariae, Semen Raphani, Rhizoma Gastrodiae, Herb Gynostemmae Pentaphylli mixed powder are broken to below the granularity 1mm, add 150 times of water by weight, decoct 5 times down at 100 ℃; The each decoction 50 minutes, cross 125 μ m sieve extract, adopt the low-voltage vacuum method to be concentrated into every 1ml and contain primary medicine 2g; Add 80% ethanol then; Make medicinal liquid contain the alcohol amount and reach 80%, placed 30 hours, filter with 106 μ m sieve; Decompression filtrate recycling ethanol contains primary medicine 1g to every 1ml and gets the concentrated solution II, and is subsequent use.
With above-mentioned alcohol extraction and water carry gained concentrated solution I and concentrated solution II merge extractum, as diluent, press the ratio mixing granulation of extractum and diluent 1:8 with mannitol, intensive drying to water content≤5% in baking oven below 80 ℃ promptly obtains medicine of the present invention.
Embodiment 5:
Get by weight: 2.5 parts of Herba Sophorae alopecuroidiss, 22 parts of Semen Cassiaes, 25 parts of Fructus Crataegis, 10 parts of Radix Pseudostellariaes, 6 parts in Rhizoma Gastrodiae, 10 parts of the Radixs Astragali, 1 part of Herb Gynostemmae Pentaphylli, 10 parts of Radix Codonopsis, 3 parts in Radix Glycyrrhizae, 5 parts of Radix Scutellariaes, 12 parts of Semen Raphanis.
Depend on pine torch, Fructus Crataegi, Herb Gynostemmae Pentaphylli, Rhizoma Gastrodiae; Be crushed to below the granularity 0.8mm; Add 10 times of 95% ethanol by weight as solvent, 800 kilo hertzs of following alcohol extractions of supersonic frequency 4 times, each 15 minutes; Cross 106 μ m sieve extract, be evaporated to every 1ml with Rotary Evaporators and contain primary medicine 4g and get the concentrated solution I;
Get Herba Sophorae alopecuroidis, Radix Pseudostellariae, 10 parts of the Radixs Astragali, Radix Codonopsis, Radix Glycyrrhizae, Radix Scutellariae, Semen Raphani and be crushed to below the granularity 1.2mm, add 15 times of water by weight, carry 4 times 15 minutes at 800 kilo hertzs of following water of supersonic frequency.Cross 150 μ m sieve extract, be concentrated into every 1ml and contain primary medicine 2g, add 95% ethanol then, make medicinal liquid contain alcohol amount and reach 90%, placed 28 hours, cross 106 μ m sieve, decompression filtrate recycling ethanol extremely every 1ml contains primary medicine 4g and gets the concentrated solution II;
With above-mentioned alcohol extraction and water carry gained concentrated solution I and concentrated solution II merge extractum; Select dextrin, starch to press the 1:1 mixed as diluent; Press the ratio mixing granulation of extractum and diluent 1:3, intensive drying to water content≤6% in baking oven below 80 ℃ promptly obtains medicine of the present invention.
Embodiment 6:
Get 0.5 part of Herba Sophorae alopecuroidis by weight, 22 parts of Semen Cassiaes, 25 parts of Fructus Crataegis, 10 parts of Radix Pseudostellariaes, 3 parts in Rhizoma Gastrodiae, 25 parts of the Radixs Astragali, 25 parts of Radix Codonopsis, 8 parts in Radix Glycyrrhizae, 80 parts of Radix Scutellariaes.
Be crushed to below the granularity 2.5mm, add 20 times of 65% ethanol by weight as solvent, reflux, extract, 5 times, each 240 minutes, cross 180 μ m sieve extract, be evaporated to every 1ml with Rotary Evaporators and contain primary medicine 0.5g and get the concentrated solution I;
Get Herba Sophorae alopecuroidis, Radix Pseudostellariae, the Radix Astragali, Radix Codonopsis, Radix Glycyrrhizae, Radix Scutellariae powder and be broken to below the granularity 5mm, add 15 times of water by weight, decoct 5 times at 90 ℃; The each decoction 120 minutes, cross 180 μ m sieve extract, be concentrated into every 1ml and contain primary medicine 0.5g; Add 65% ethanol then, make medicinal liquid contain the alcohol amount and reach 60%, placed 10 hours; Cross 180 μ m sieve, decompression filtrate recycling ethanol contains primary medicine 0.5g to every 1ml and gets the concentrated solution II;
With above-mentioned alcohol extraction and water carry gained concentrated solution I and concentrated solution II merge extractum, select starch as diluent, press the ratio mixing granulation of extractum and diluent 1:7, intensive drying to water content≤6% in 80 ℃ of following baking ovens promptly obtains medicine of the present invention.
Embodiment 7:
Get 2 parts of Herba Sophorae alopecuroidiss by weight, 30 parts of Semen Cassiaes, 20 parts of Fructus Crataegis, 25 parts of Radix Pseudostellariaes, 3 parts in Rhizoma Gastrodiae.
Depend on that pine torch, Fructus Crataegi, Rhizoma Gastrodiae powder are broken to below the granularity 1mm; Add 12 times of 80% ethanol by weight as solvent, 500 kilo hertzs of following alcohol extractions of supersonic frequency 3 times, each 50 minutes; Cross 212 μ m sieve extract, be evaporated to every 1ml with Rotary Evaporators and contain primary medicine 1.5g and get the concentrated solution I;
Get Herba Sophorae alopecuroidis, Radix Pseudostellariae is crushed to below the granularity 1mm, adds 25 times of water by weight, carry 4 times at 500 kilo hertzs of following water of supersonic frequency; Each 50 minutes, cross 212 μ m sieve extract, be concentrated into every 1ml and contain primary medicine 1.5g; Add 80% ethanol then, make medicinal liquid contain the alcohol amount and reach 60%, placed 10 hours; Cross 212 μ m sieve, decompression filtrate recycling ethanol contains primary medicine 1.5g to every 1ml and gets the concentrated solution II;
With above-mentioned alcohol extraction and water carry gained concentrated solution I and concentrated solution II merge extractum, select mannitol as diluent, press the ratio mixing granulation of extractum and diluent 1:5, intensive drying to water content≤8% in 65 ℃ of following baking ovens promptly obtains medicine of the present invention.
Embodiment 8:
Get 2.5 parts of Herba Sophorae alopecuroidiss by weight, 25 parts of Semen Cassiaes, 28 parts of Fructus Crataegis, 16 parts of Radix Pseudostellariaes, 7 parts in Rhizoma Gastrodiae, 12 parts of Herb Gynostemmae Pentaphylli, 14 parts of Radix Codonopsis, 7 parts in Radix Glycyrrhizae, 18 parts of Semen Raphanis.
Depend on that pine torch, Fructus Crataegi powder are broken to below the granularity 2mm; Add 20 times of 75% ethanol by weight as solvent, 300 kilo hertzs of following alcohol extractions of supersonic frequency 5 times, each 180 minutes; Cross 150 μ m sieve extract, be evaporated to every 1ml with Rotary Evaporators and contain primary medicine 2.5g and get the concentrated solution I;
Get Herba Sophorae alopecuroidis, Radix Pseudostellariae, the Radix Astragali, Radix Codonopsis, Radix Glycyrrhizae, Radix Scutellariae, Semen Raphani, Rhizoma Gastrodiae, Herb Gynostemmae Pentaphylli powder and be broken to below the granularity 2mm, add 18 times of water by weight, carry 5 times at 300 kilo hertzs of following water of supersonic frequency; Each 180 minutes, cross 150 μ m sieve extract, be concentrated into every 1ml and contain primary medicine 2g; Add 75% ethanol then, make medicinal liquid contain the alcohol amount and reach 60%, placed 35 hours; Cross 150 μ m sieve, decompression filtrate recycling ethanol contains primary medicine 2.5g to every 1ml and gets the concentrated solution II;
With above-mentioned alcohol extraction and water carry gained concentrated solution I and concentrated solution II merge extractum; Select sucrose, dextrin, starch to press the 1:1:1 mixed as diluent; Press extractum and diluent 1:5.5 mixing granulation; Intensive drying to water content≤6% in 75 ℃ of following baking ovens promptly obtains medicine of the present invention.
Embodiment 9:
Get 1.8 parts of Herba Sophorae alopecuroidiss by weight, 26 parts of Semen Cassiaes, 30 parts of Fructus Crataegis, 10 parts of Radix Pseudostellariaes, 3 parts in Rhizoma Gastrodiae, 12 parts of Radix Codonopsis, 3.5 parts in Radix Glycyrrhizae, 12 parts of Radix Scutellariaes.
Depend on that pine torch, Fructus Crataegi, Rhizoma Gastrodiae powder are broken to below the granularity 0.5mm; Add 24 times of 94% ethanol by weight as solvent; 450 kilo hertzs of following alcohol extractions of supersonic frequency 3 times; Each 100 minutes, cross 75 μ m sieve extract, be evaporated to every 1ml with Rotary Evaporators and contain primary medicine 3.5g and get the concentrated solution I;
Get Herba Sophorae alopecuroidis, Radix Pseudostellariae, Radix Codonopsis, Radix Glycyrrhizae, Radix Scutellariae powder and be broken to below the granularity 0.5mm, add 30 times of water by weight, carry 3 times at 450 kilo hertzs of following water of supersonic frequency; Each 100 minutes, cross 75 μ m sieve extract, be concentrated into every 1ml and contain primary medicine 1g; Add 90% ethanol then, make medicinal liquid contain the alcohol amount and reach 80%, placed 20 hours; Cross 75 μ m sieve, decompression filtrate recycling ethanol contains primary medicine 3.5g to every 1ml and gets the concentrated solution II;
With above-mentioned alcohol extraction and water carry gained concentrated solution I and concentrated solution II merge extractum; Select sucrose, starch, mannitol to press the 1:2:1 mixed as diluent; Press the ratio mixing granulation of extractum and diluent 1:7; Intensive drying to water content≤5% in 70 ℃ of following baking ovens promptly obtains medicine of the present invention.
Embodiment 10:
Get 1.3 parts of Herba Sophorae alopecuroidiss by weight, 32 parts of Semen Cassiaes, 27 parts of Fructus Crataegis, 17 parts of Radix Pseudostellariaes, 14 parts in Rhizoma Gastrodiae, 21 parts of the Radixs Astragali, 14 parts of Herb Gynostemmae Pentaphylli, 16 parts of Radix Codonopsis, 6 parts in Radix Glycyrrhizae, 16 parts of Semen Raphanis.
Depend on that pine torch, Fructus Crataegi, Rhizoma Gastrodiae, Herb Gynostemmae Pentaphylli powder are broken to below the granularity 0.7mm; Add 22 times of 85% ethanol by weight as solvent; 750 kilo hertzs of following alcohol extractions of supersonic frequency 3 times; Each 90 minutes, cross 150 μ m sieve extract, be evaporated to every 1ml with Rotary Evaporators and contain primary medicine 0.8g and get the concentrated solution I;
Take by weighing Herba Sophorae alopecuroidis, Radix Pseudostellariae, the Radix Astragali, Radix Codonopsis, Radix Glycyrrhizae, Semen Raphani by proportioning and be crushed to below the granularity 2mm, add 18 times of water by weight, decoct 5 times at 98 ℃; The each decoction 45 minutes, cross 150 μ m sieve extract, be concentrated into every 1ml and contain primary medicine 0.8g; Add 85% ethanol then, make medicinal liquid contain the alcohol amount and reach 70%, placed 30 hours; Cross 100 μ m sieve, decompression filtrate recycling ethanol contains primary medicine 0.8g to every 1ml and gets the concentrated solution II;
With above-mentioned alcohol extraction and water carry gained concentrated solution I and concentrated solution II merge extractum; Press any 2:1 mixed as diluent with starch, mannitol; Press the ratio mixing granulation of extractum and diluent 1:4.5; Intensive drying to water content≤7% in 70 ℃ of following baking ovens promptly obtains medicine of the present invention.
Embodiment 11:
Get 2.4 parts of Herba Sophorae alopecuroidiss by weight, 24 parts of Semen Cassiaes, 32 parts of Fructus Crataegis, 18 parts of Radix Pseudostellariaes, 18 parts in Rhizoma Gastrodiae, 18 parts of the Radixs Astragali, 10 parts of Herb Gynostemmae Pentaphylli, 10 parts of Radix Codonopsis, 1.5 parts in Radix Glycyrrhizae, 5 parts of Radix Scutellariaes, 5 parts of Semen Raphanis.
Depend on that pine torch, Fructus Crataegi, Rhizoma Gastrodiae, Herb Gynostemmae Pentaphylli powder are broken to below the granularity 0.5mm; Add 16 times of 92% ethanol by weight as solvent, reflux, extract, 6 times, each 120 minutes; Cross 75 μ m sieve extract, be evaporated to every 1ml with Rotary Evaporators and contain primary medicine 2.5g and get the concentrated solution I;
Get Herba Sophorae alopecuroidis, Radix Pseudostellariae, the Radix Astragali, Radix Codonopsis, Radix Glycyrrhizae, Radix Scutellariae, Semen Raphani and be crushed to below the granularity 2mm, add 5～30 times of water by weight, carry 5 times at 850 kilo hertzs of following water of supersonic frequency; Each 60 minutes, cross 100 μ m sieve extract, be concentrated into every 1ml and contain primary medicine 1.5g; Add 85% ethanol then, make medicinal liquid contain the alcohol amount and reach 80%, placed 20 hours; Cross 75 μ m sieve, decompression filtrate recycling ethanol contains primary medicine 2.5g to every 1ml and gets the concentrated solution II;
With above-mentioned alcohol extraction and water carry gained concentrated solution I and concentrated solution II merge extractum, as diluent, press the ratio mixing granulation of extractum and diluent 1:7.5 with starch, intensive drying to water content≤5% in baking oven below 75 ℃ promptly obtains medicine of the present invention.
Claims (3)
1. medicine of transferring blood fat is characterized in that being produced by the medical material of following weight proportion:
0.5～8 part of Herba Sophorae alopecuroidis, 10～35 parts of Semen Cassiaes, 10～35 parts of Fructus Crataegis, 8～30 parts of Radix Pseudostellariaes, 3～25 parts in Rhizoma Gastrodiae.
2. the medicine of accent blood fat according to claim 1 is characterized in that described medical material is:
0.5～2.5 part of Herba Sophorae alopecuroidis, 22～35 parts of Semen Cassiaes, 22～35 parts of Fructus Crataegis, 10～25 parts of Radix Pseudostellariaes, 3～18 parts in Rhizoma Gastrodiae.
3. according to the production of medicine method of claim 1 or the described accent blood fat of 2 each claim, it is characterized in that containing following technical process:
Alcohol extraction: take by weighing Semen Cassiae, Fructus Crataegi, Rhizoma Gastrodiae powder by proportioning and be broken to below the granularity 5mm; Add 6～24 times of 35～95% ethanol by weight as solvent; Reflux, extract, 2～6 times; Each 15～360 minutes, mistake≤250 μ m sieve extract, be evaporated to every 1ml with Rotary Evaporators and contain primary medicine 0.2～4g and get the concentrated solution I;
Water is carried: take by weighing Herba Sophorae alopecuroidis, Radix Pseudostellariae by proportioning, be crushed to below the granularity 5mm, add 5～30 times of water by weight; Decoct 1～5 time at 85～110 ℃, decocted 15～300 minutes at every turn, mistake≤250 μ m sieve extract; Be concentrated into every 1ml and contain primary medicine 0.2～4g, add 35～95% ethanol then, make medicinal liquid contain the alcohol amount and reach 50～90%; Placed 6～48 hours, and filtered, decompression filtrate recycling ethanol contains primary medicine 0.2～4g to every 1ml and gets the concentrated solution II;
Become the preparation of agent: with above-mentioned alcohol extraction and water carry gained concentrated solution I and concentrated solution II filtrate merge extractum; In selection sucrose, dextrin, starch or the mannitol one or more are pressed arbitrary proportion and are mixed as diluent; Press the ratio mixing granulation of extractum and diluent 1:1.5～8; Intensive drying to water content≤10% in baking oven below 80 ℃ promptly obtains medicine of the present invention.
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| CN102293810A (en) * | 2011-07-05 | 2011-12-28 | 食品行业生产力促进中心 | Pseudostellaria root functional component extraction method by ultrasonic |
| CN104398852A (en) * | 2014-11-10 | 2015-03-11 | 成都果睿医药科技有限公司 | Pharmaceutical composition containing cassia seed for reducing blood fat |
| CN116098981A (en) * | 2023-01-10 | 2023-05-12 | 辽宁农业职业技术学院 | Medicinal and edible traditional Chinese medicine composition for reducing blood fat and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1253815A (en) * | 1999-11-24 | 2000-05-24 | 刘思宁 | Preparation for external application for curing hypertension and hyperlipemia and its preparation method |
| CN1413601A (en) * | 2001-10-22 | 2003-04-30 | 孟宪茹 | Chinese medicine for compound circulation treatment of angiocardiopathy and cerebrovascular disease |
| CN1772208A (en) * | 2004-11-08 | 2006-05-17 | 北京万邦医药投资有限公司 | Chinese medicine composition for preventing and treating hypertension, hyperlipemia and hyperglycemia |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1253815A (en) * | 1999-11-24 | 2000-05-24 | 刘思宁 | Preparation for external application for curing hypertension and hyperlipemia and its preparation method |
| CN1413601A (en) * | 2001-10-22 | 2003-04-30 | 孟宪茹 | Chinese medicine for compound circulation treatment of angiocardiopathy and cerebrovascular disease |
| CN1772208A (en) * | 2004-11-08 | 2006-05-17 | 北京万邦医药投资有限公司 | Chinese medicine composition for preventing and treating hypertension, hyperlipemia and hyperglycemia |
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| 杜华.中医药治疗高脂血症30例.《四川中医》.2004,第22卷(第6期), * |
| 王明远.复方苦豆子制剂对实验性高血脂动物血脂的影响.《石河子大学学报(自然科学版)》.2006,第24卷(第2期), * |
| 马建慧.调脂方治疗高脂血症30例.《陕西中西》.2006,第27卷(第2期), * |
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