CN1253815A - Preparation for external application for curing hypertension and hyperlipemia and its preparation method - Google Patents
Preparation for external application for curing hypertension and hyperlipemia and its preparation method Download PDFInfo
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- CN1253815A CN1253815A CN 99115920 CN99115920A CN1253815A CN 1253815 A CN1253815 A CN 1253815A CN 99115920 CN99115920 CN 99115920 CN 99115920 A CN99115920 A CN 99115920A CN 1253815 A CN1253815 A CN 1253815A
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Abstract
The external application medicinal preparation for curing hypertension and hyperlipemia is formed from the Chinese medicinal materials of uncaria stem and thorn, dogbane, gynostemma pentaphylla, eucommia bark, yinyanglian (a Chinese herbal medicine), prunella, fetid cassia seed, salvia root and clonidine and hydrochlorothiazide. Said invented medicine can be applied on the skin so as to attain the goal of reducing blood pressure and reducing blood-lipid by means of transdermal absorption. Said invention is low in cost, convenient in application, and has no toxic side effect.
Description
The present invention is a kind of treatment hypertension, hyperlipidemia, the Transdermal absorption external preparation of being made up of Chinese medicine and western medicine.
Hypertension is a kind of worldwide commonly encountered diseases, its sickness rate is 11.8% in China, be about 20% in developed country, hypertension, hyperlipidemia are again coronary heart disease, apoplexy, arteriosclerotic main pathogenic factors, and the case fatality rate of the cardiovascular and cerebrovascular disease that is caused by hypertension occupies position first of China's case fatality rate.
The objective of the invention is at the problem in the existing treatment, a kind of no pain in effective, cheap, easy to use, the treatment, nontoxic pair of effect, the treatment hypertension that does not influence gastrointestinal function, external preparation of hyperlipidemia for the treatment of is provided.
For achieving the above object, solution of the present invention is: raw material is made up of following Chinese medicine and western medicine, that is, Chinese medicine Ramulus Uncariae Cum Uncis, Herba Apocyni veneti, Herb Gynostemmae Pentaphylli, the Cortex Eucommiae, Rhizoma Polygoni Cuspidati, Spica Prunellae, Semen Cassiae, Radix Salviae Miltiorrhizae and clonidine (dichloroaniline imidazoles), hydrochlorothiazide are formed.
The prescription foundation: hypertension, high fat of blood doctor trained in Western medicine are thought the higher nervous activity dysfunction, and the autonomic center irritability increases, and the disease that the imbalance of metabolism and endocrine function causes, is had a liking for tobacco and wine and family history is relevant at this disease and age, occupation.Motherland's medical science thinks that primary disease is troubled thoughts brain anger, the sad god of consumption or surfeit delicious food savoury, block meridians and worn with age, deficiency of kidney-YIN, the kidney failing to nourish the liver, the liver failing to be nourished, liver-yang are high partially and fall ill, and the rule of treatment is answered suppressing the hyperactive liver and subsiding YANG, tranquilizing by nourishing the heart, nourishing the liver and kidney, dredged channels and activating collaterals, activating blood circulation to dissipate blood stasis.According to Chinese and western medicine theory separately, taked following prescription:
Ramulus Uncariae Cum Uncis: nature and flavor sweetness and bitterness is slightly cold, and the heat clearing away suppressing the hyperactive liver is arranged, the arresting convulsion function that relieves dizziness, high fever, infantile convulsions, epilepsy, etc., and the zoopery proof has the effect of calm and blood pressure lowering.Main effect link is at nerve centre, and is relevant with the sympathetic nerve blocking-up, and the effect (1668 pages of Chinese medicine voluminous dictionaries) of blood vessel dilating is arranged.
Herba Apocyni veneti: nature and flavor sweetness and bitterness cold.The energy heat clearing away and internal heat reducing, suppressing the hyperactive liver to relieve the wind syndrome.Composition mainly contains flavone and rutin in its leaf, but the blood pressure lowering calmness.Root contains cardiotonic glycoside and strophanthin, and the heart tonifying diuresis is arranged.The zoopery proof has stronger hypotensive effect to the Canis familiaris L. of renal hypertension.(1355 pages of Chinese medicine voluminous dictionaries)
Rhizoma Polygoni Cuspidati: nature and flavor sweetness and bitterness is slightly cold, energy suppressing the hyperactive liver and subsiding YANG, soothing the channels and quicking the network vessels, nourishing liver and kidney, clearing heat and relieving fidgetness.Experimental results show that the effect of calmness, blood pressure lowering and cholesterol reducing, also have the function (Xinjiang Chinese herbal medicine) of blood sugar lowering.
Herb Gynostemmae Pentaphylli: bitter in the mouth, cold in nature, nontoxic.Contain the Ginsenoside Rb
1, Rd
3, Rg
3Deng and gypenoside.Pharmacology and clinical research prove: this product has the effect of remarkable reduction serum cholesterol (TCH), triglyceride (TG), low density lipoprotein, LDL (LDL-C) and high density lipoprotein increasing (IIDL-C).Can also regulate lipid metabolism, stop lipid effect such as long-pending and raise immunity in the Shen of blood vessel wall.
The Cortex Eucommiae: nature and flavor are hot flat, go into the Liver and kidney warp, and the function of invigorating the liver and kidney, bone and muscle strengthening is arranged.Contain compositions such as gutta-percha, alkaloid, aldose, zoopery has the effect of persistent hypotensive effect and coronary artery dilator blood vessel and renal blood vessels.
Spica Prunellae: property is equalled little hardship, contains oleanolic acid, vitamin C, and water-soluble inorganic salt (wherein 68% is potassium chloride) zoopery has obvious hypotensive effect (1827 pages of Chinese medicine voluminous dictionaries).
Radix Salviae Miltiorrhizae: the nature and flavor hardship is slightly cold, and major function is a blood circulation promoting and blood stasis dispelling, and pharmacology is done the interaction energy calmness, calmed the nerves, and expansion peripheral vessels and blood pressure lowering can improve cAMP in the cell can anticoagulant and microcirculation improvement, and the lowering fat and protecting liver function is arranged.
Semen Cassiae: nature and flavor sweetness and bitterness is slightly cold, and returns the Liver and kidney warp, can drive having a dizzy spell of the hot and suffocating regulating liver-QI sun rising of liver and gall by liver heat removing and eyesight improving.Pharmacological testing has the effect of blood pressure lowering, heart tonifying, diuresis and blood fat reducing.
Clonidine: be the maincenter receptor agonist, can touch prominent cephacoria α by excited maincenter
zReceptor is by excited cerebrovascular motorium with suppress sympathetic nerve and improve vagal tone, suppress the secretion of catecholamine, and can reduce the effect of renin activity, thereby cause blood pressure drops, " clonidine preparation capable of permeating skin (catapresTTs) is more effective and safety to senile hypertension ".(Clin pharmacol 1989; 29:123 English)
Hydrochlorothiazide: mainly press down agent kidney medullary loop ascending branch cortex portion to receiving and the absorption again of chlorine, thereby promote kidney that the drainage of sodium chloride is produced diuresis.Can coordinate and strengthen the hypotensive effect of other depressor.(the 12nd edition 462 pages of new pharmacologies).
The present invention is applied to clinical 60 examples, average systolic 167.4 ± 15.0mm/Hg before the treatment, diastolic pressure 97.6 ± 10.3mm/Hg, after using this preparation blood pressure lowering spray Kang Sizhou, average systolic is 139.9 ± 13.0mm/Hg, soothing liver-QI is pressed 86.7 ± 7.5mm/Hg (P＜0.01) curative effect highly significant, and pays effect without any bad poison.And can microcirculation improvement and certain effect for reducing fat arranged.
The objective of the invention is to be achieved through the following technical solutions:
One, a kind of external preparation for the treatment of hypertension, hyperlipidemia---blood pressure lowering spray health, it is formed drug solution and is respectively by weight percentage: Ramulus Uncariae Cum Uncis 15, Herba Apocyni veneti 12, Herb Gynostemmae Pentaphylli 12, Rhizoma Polygoni Cuspidati 12, the Cortex Eucommiae 12, Spica Prunellae 10, Semen Cassiae 6, Radix Salviae Miltiorrhizae 6, clonidine (dichloroaniline imidazoles) 1, hydrochlorothiazide 1.
Two, embodiment
With Ramulus Uncariae Cum Uncis, Herba Apocyni veneti,, Herb Gynostemmae Pentaphylli, the Cortex Eucommiae, Rhizoma Polygoni Cuspidati, Spica Prunellae, Semen Cassiae, Radix Salviae Miltiorrhizae drop into the sandwich interlayer pressure pan internal heating and cover medical material to soaking fully, (require 113～115 ℃ of temperature, pressure is 1.5kg/cm in the water proof heating
2) decoct 30min and remove slag, when the medicinal liquid evaporation and concentration is concentrated at 2: 1, adding 95% ethanol of equivalent again, hybrid filtering reclaims ethanol, adds activated carbon decolorizing by 2%, and it is standby to make Chinese medicine stock solution after the filtration.Get Chinese medicine stock solution 200ml, add clonidine 1g and hydrochlorothiazide 1g and add aquae destillata again, stir, add an amount of essence and derivant azone again to 1000ml, hybrid filtering bottling vanning, standby by cobalt 60 illumination-based disinfections at last.
Three, effect
The external hypertension and hyperlipemia cutaneous permeable agent treatment hypertension of fast method preparation in the use, hyperlipidemia, definite effect uses said preparation after 3 days, can make systolic pressure reduce by 20～30mm/Hg, and diastolic pressure reduces by 8～10mm/Hg.After around using, blood fat also has decline in various degree.
Four, characteristics
1. said preparation is to form with technological means is refining according to Chinese medicine and western medicine theory and the bonded method of Chinese medicine and western medicine.
2. by the skin spraying, Transdermal absorption reaches the purpose of blood pressure lowering, blood fat reducing.
3. without digestive tract, eliminated stimulation or infringement, avoided the decomposition of factors such as pH value, food and Digestive system medicine to intestines and stomach.
4. avoid liver first-pass effect, reduce burden of liver.
5. therapeutic effect is definite, and is easy to use, cheap, is fit to China's actual conditions.
6. experimental results show that the function that except that blood pressure lowering, blood fat reducing, also has microcirculation improvement.
7. can be developed to spray liniment, toothpaste, soap, the use of wiping face wet goods product, have a extensive future.
Five, using method
The through port transmucosal absorbed and reaches the purpose of blood pressure lowering, blood fat reducing when the each once a day 3～5ml of spray liniment spraying extremity and skin of abdomen, toothpaste can a twice-daily be brushed teeth.
Six, poison is paid effect
The present invention's blood pressure lowering, blood fat reducing by skin or mucosa and absorption; The no any poison of zoopery proof is paid effect.
Claims (2)
- One, a kind of external preparation for the treatment of hypertension, hyperlipidemia.It is characterized in that: it is made up of following raw materials according, and described composition of raw materials ratio is (by solution quality %): Ramulus Uncariae Cum Uncis 15, the Cortex Eucommiae 12, Herb Gynostemmae Pentaphylli 12, Herba Apocyni veneti 12, Rhizoma Polygoni Cuspidati 12, Spica Prunellae 10, Semen Cassiae 10, Radix Salviae Miltiorrhizae 10, clonidine 1, hydrochlorothiazide 1 are formed.
- Two, preparation method is: with above-mentioned Chinese medicine through decoct, concentrate, alcohol analyses, decolours, filters, adds clonidine, hydrochlorothiazide in proportion, adds an amount of essence and azone, process cobalt 60 illumination-based disinfections are standby after the bottling.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 99115920 CN1117584C (en) | 1999-11-24 | 1999-11-24 | Preparation for external application for curing hypertension and hyperlipemia and its preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 99115920 CN1117584C (en) | 1999-11-24 | 1999-11-24 | Preparation for external application for curing hypertension and hyperlipemia and its preparation method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1253815A true CN1253815A (en) | 2000-05-24 |
| CN1117584C CN1117584C (en) | 2003-08-13 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 99115920 Expired - Fee Related CN1117584C (en) | 1999-11-24 | 1999-11-24 | Preparation for external application for curing hypertension and hyperlipemia and its preparation method |
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|---|---|
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1294967C (en) * | 2003-12-15 | 2007-01-17 | 王建民 | Externally applied plaster for treating hypertension |
| CN100402057C (en) * | 2006-04-05 | 2008-07-16 | 季凤文 | Hypotensor pillow |
| CN101480472B (en) * | 2008-01-09 | 2012-02-29 | 石河子大学 | Medicament for reducing blood pressure and regulating blood fat and production method |
| CN113694110A (en) * | 2021-09-01 | 2021-11-26 | 深圳市资福药业有限公司 | Incadronate disodium product and preparation method thereof |
-
1999
- 1999-11-24 CN CN 99115920 patent/CN1117584C/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1294967C (en) * | 2003-12-15 | 2007-01-17 | 王建民 | Externally applied plaster for treating hypertension |
| CN100402057C (en) * | 2006-04-05 | 2008-07-16 | 季凤文 | Hypotensor pillow |
| CN101480472B (en) * | 2008-01-09 | 2012-02-29 | 石河子大学 | Medicament for reducing blood pressure and regulating blood fat and production method |
| CN113694110A (en) * | 2021-09-01 | 2021-11-26 | 深圳市资福药业有限公司 | Incadronate disodium product and preparation method thereof |
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| Publication number | Publication date |
|---|---|
| CN1117584C (en) | 2003-08-13 |
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