CN103432200B - A kind of medicine for the treatment of Orthopeadic Surgery disease - Google Patents
A kind of medicine for the treatment of Orthopeadic Surgery disease Download PDFInfo
- Publication number
- CN103432200B CN103432200B CN201310420875.2A CN201310420875A CN103432200B CN 103432200 B CN103432200 B CN 103432200B CN 201310420875 A CN201310420875 A CN 201310420875A CN 103432200 B CN103432200 B CN 103432200B
- Authority
- CN
- China
- Prior art keywords
- parts
- salviae miltiorrhizae
- extract
- rhizoma chuanxiong
- radix salviae
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides a kind of medicine for the treatment of cardiovascular and Orthopeadic Surgery disease, be made up of the component of following masses part: Radix Notoginseng total arasaponins 30 ~ 80 parts, Radix Salviae Miltiorrhizae 200 ~ 250 parts, Folium Ginkgo 200 ~ 250 parts, Rhizoma Chuanxiong 150 ~ 200 parts.By adding ethanol carry out reflux, extract, twice to Radix Salviae Miltiorrhizae, Folium Ginkgo, Rhizoma Chuanxiong coarse powder, filtering residue is decocted with water again, after then gained ethanol extract and decocting liquid being merged, be condensed into thick paste; The fine powder adding Radix Notoginseng total arasaponins again obtains the Chinese medicine composition with blood circulation invigorating efficacies.This Chinese medicine composition, has blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, and the effect such as to promote blood circulation active, also has the immunologic function of good easing pain and diminishing inflammation, antiallergic, enhancing body.Accelerate the Healing of fracture and wound tissue.For the good effect of cardiovascular disease, the caused by energy stagnation and blood stasis thoracic obstruction and angina pectoris, dizzy i.e. cerebral arteriosclerosis, thromboembolic stroke.And there is significant curative effects such as recovering soon, relapse rate is low, safety is high, have no side effect, simple for production.
Description
Technical field
The present invention relates to a kind of medicine, particularly relate to one and there is blood circulation invigorating efficacies, the Chinese medicine composition of cardiovascular and Orthopeadic Surgery disease can be treated simultaneously, belong to biological technical field.
Background technology
Along with our people's growth in the living standard, the quality of life of resident constantly improves, and the diet not science of many people, think that plenty of meat and fish is exactly the raising of quality of life, actually this is not so.Middle age, the overweight people of more than 45 years old, there is hyperlipemia family history person, often participate in food and drink dinner party person, highly spiritual tense working person, easily suffer from cardiovascular disease.Common sympton had palpitation, faint, dyspnea, dizzy etc., directly affect the healthy of middle-aged and elderly people and quality of life.
In addition, Orthopeadic Surgery disease is also a kind of serious multiple diseases, as various acute or chronic soft tissue injury, acute and chronic neck lumbar muscular injury, soft tissue of joint damage, cervical spondylosis, lumbar spondylosis, scapulohumeral periarthritis, tennis elbow, fracture etc., also brings puzzlement.
At present, though the medicine for the treatment of this kind of disease has multiple, there is the problem of toxic and side effects in chemical drugs wherein, and eutherapeutic Chinese medicine preparation and also seldom, especially to cardiovascular disease and all medicable Chinese medicine of Orthopeadic Surgery disease rare especially.
Summary of the invention
For overcoming the problems such as curative effect is slow, side effect is large, the object of the present invention is to provide a kind of medicine with blood circulation invigorating efficacies, to cardiovascular disease and Orthopeadic Surgery disease all powerful.
The present invention is to provide a kind of like this medicine for the treatment of cardiovascular and Orthopeadic Surgery disease, it is characterized in that being made up of the component of following masses part:
Radix Notoginseng total arasaponins 30 ~ 80 parts
Radix Salviae Miltiorrhizae 200 ~ 250 parts
Folium Ginkgo 200 ~ 250 parts
Rhizoma Chuanxiong 150 ~ 200 parts.
The invention provides a kind of medicine for the treatment of cardiovascular and Orthopeadic Surgery disease, preferred ingredient is made up of the component of following masses part:
Radix Notoginseng total arasaponins 50 parts
Radix Salviae Miltiorrhizae 225 parts
Folium Ginkgo 225 parts
Rhizoma Chuanxiong 200 parts.
Described Radix Notoginseng total arasaponins is commercial products.
The medicine for the treatment of cardiovascular provided by the invention and Orthopeadic Surgery disease is prepared through following method:
(1) by following mass parts feeding:
Radix Notoginseng total arasaponins 30 ~ 80 parts
Radix Salviae Miltiorrhizae 200 ~ 250 parts
Folium Ginkgo 200 ~ 250 parts
Rhizoma Chuanxiong 150 ~ 200 parts;
(2) by the Radix Salviae Miltiorrhizae of step (1), Rhizoma Chuanxiong, Folium Ginkgo, decoct with water 2-3 time, filter to get filtrate and filtering residue, in filtrate, add Radix Notoginseng total arasaponins, the decoction of cardiovascular and Orthopeadic Surgery disease must be treated.
The medicine for the treatment of cardiovascular provided by the invention and Orthopeadic Surgery disease is prepared through following method:
(1) by following mass parts feeding:
Radix Notoginseng total arasaponins 30 ~ 80 parts
Radix Salviae Miltiorrhizae 200 ~ 250 parts
Folium Ginkgo 200 ~ 250 parts
Rhizoma Chuanxiong 150 ~ 200 parts;
(2) Radix Salviae Miltiorrhizae in step (1), Rhizoma Chuanxiong, ginkgo leaf powder are broken into coarse powder, be 1 ︰ 4 ~ 8 by solid-liquid mass ratio, add in Radix Salviae Miltiorrhizae, Folium Ginkgo, Rhizoma Chuanxiong coarse powder mass concentration be 95% ethanol carry out reflux, extract, 1 ~ 2 hour, filter to get filtrate and filtering residue; Be 1 ︰ 3 ~ 7 by solid-liquid mass ratio again, add in filtering residue mass concentration be 50% ethanol carry out reflux, extract, 0.5 ~ 1.5 hour, then filter to get filtrate and filtering residue; Merge the filtrate of twice reflux, extract, and reclaim ethanol and obtain ethanol extract;
(3) in step (2) gained filtering residue, be 1 ︰ 4 ~ 8 by solid-liquid mass ratio, decoct with water 1 ~ 3 hour, filter and obtain decocting liquid; After step (2) gained ethanol extract and decocting liquid being merged, relative density when being concentrated into 50 DEG C is the thick paste of 1.35 ~ 1.40 again; Finally Radix Notoginseng total arasaponins fine powder is added in thick paste, mix homogeneously, add appropriate customary adjuvant, by conventional method of the prior art, make any one oral formulations following of pharmaceutically acceptable treatment cardiovascular and Orthopeadic Surgery disease: the preparations such as tablet, capsule, soft capsule, granule, pill, oral liquid.
Described Radix Notoginseng total arasaponins: nature and flavor: bitter in the mouth, micro-sweet; Cure mainly: blood circulation promoting and blood stasis dispelling, promote blood circulation active, there is the effect of anticoagulant and increase heart and brain blood flow.Radix Salviae Miltiorrhizae: nature and flavor: bitter in the mouth, cold nature; Enter heart channel; Effect: promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, removing heat from blood eliminating carbuncle, clear away heart-fire relieving restlessness, nourishing blood to tranquillize the mind.Folium Ginkgo: sweet: bitter, flat; Cure mainly: blood circulation promoting and blood stasis dispelling, change turbid blood fat reducing, removing obstruction in the collateral to relieve pain.Rhizoma Chuanxiong: pungent: temperature: cure mainly: blood-activating and qi-promoting, wind-expelling pain-stopping.Each composition of the present invention is national corporation of medical herbs commercially available prod.
The invention provides the pharmacological action of medicine:
Modern medicine study confirms, Radix Notoginseng total arasaponins (PNS) has many-sided biological activity, is a kind of active drug of prevention and cure of cardiovascular disease.There is effect, the more widely antiarrhythmic effects such as obvious heart tonifying, coronary artery dilator, increase coronary flow, myocardial metabolism of improving, free radical resisting, Ca2+ overloading, be improved hemorheology and microcirculatory effect, have antiplatelet aggregation and anti-thrombosis function, have certain effect for reducing fat and good study of anti-atherogenic effect etc., there is larger exploitation prospect.
Radix Salviae Miltiorrhizae mainly contains blood circulation promoting and blood stasis dispelling, the effect of nourishing blood to tranquillize the mind.Be widely used in the pain over the chest and back of internal medicine, side of body rib epigastric pain, hypertension, apoplexy, apoplexy sequela, cardiopalmus, palpitation with a distress feeling, irritated insomnia etc.; The thrombophlebitis, vasculitis etc. of surgery; The amenorrhea of department of obstetrics and gynecology, dysmenorrhea, menoxenia, prolonged lochia, can apply separately, main containing TANSHINONES, salvianolic acid first, second, third and vitamin etc., it can expand peripheral vessels, reduce blood pressure, coronary artery dilator, increases arteria coronaria vascular flow, there is the effect of anticoagulation and antiplatelet aggregation, also have effect of blood sugar lowering, stable, calm, analgesia.Radix Salviae Miltiorrhizae enters blood system, and promoting the circulation of blood falls in hardship, and the overstocked row then stasis of blood only unstings; Radix Salviae Miltiorrhizae is cold in nature, therefore has clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling, the effect of menstruction regulating and pain relieving; Radix Salviae Miltiorrhizae both can lead to thinking, the heat in purifying the blood again, therefore the effect having clearing heat and relieving fidgetness; So, Radix Salviae Miltiorrhizae to trusted subordinate's pain caused by the stagnant detention of the stasis of blood, pain in chest and hypochondrium caused by liver and spleen blood stasis defect, and heat diseases such as point finding dysphoria and insomnia of joining the army are all effective in cure.
Semen Ginkgo is Relict Plant the most ancient in existing seed plant, becomes the seeds of China's uniqueness, be described as " living fossil " at academia always after the 4th century glacier.So it is " palo santo ", " god tree " that our people always worships Semen Ginkgo.The effective medicinal component of kind more than 160 can be extracted from Semen Ginkgo.The most important effective ingredient of Folium Ginkgo is bilobalide and flavonol.
The clinical practice of Folium Ginkgo, in motherland's medical science, has activating blood circulation to dissipate blood stasis and dredge the collateral pain relieving, changes effect of turbid blood fat reducing, clinical obstruction of qi in the chest and cardialgia, apoplexy, the hemiplegia caused for obstruction of collaterals by blood stasis, and stiff tongue language is stuttering; Treating Stable Angina Pectoris of Coronary Artery Disease, cerebral infarction and hyperlipemia are shown in above-mentioned patient.The bitter lactone of Folium Ginkgo institute composition containing ginkgo, has powerful PAF antagonist, wherein especially obvious with GB, and PAF antagonism has high degree of specificity and dose dependent.Flavone compound contained by Folium Ginkgo has powerful effect of scavenging radical, suppresses the generation of free radical, to the Cell membrane lipids peroxidating that free radical resisting causes, thus can the integrity of Cell protection film.In addition, Folium Ginkgo extract can also be eliminated human free radical, improve immunity of human body itself, prevents senile plaque, skin protection, beauty treatment, radiant skin etc.
The pharmacological action of Folium Ginkgo: to platelet aggregation and anastalsis; To the effect of myocardial function and myocardial infarction; To the effect of blood vessel; To the protective effect of brain; Folium Ginkgo is one of Chinese medicine with resistant activity gene ability, in protection lipid (ingredient of cell membrane) from very effective in free radical injury.Consider that brain cell contains the unsaturated fatty acid of maximum concentration in all cells, this effectively supports the protective effect of Semen Ginkgo to cardiovascular and central nervous system.Folium Ginkgo can promote brain and the sanguimotor ability of acra, and protection tremulous pulse, vein and blood capillary escape injury, and strengthen intensity and the elasticity of blood vessel.In addition, Semen Ginkgo is by reducing platelet (one forms arteriosclerotic key factor) viscosity, protecting erythrocyte escape injury and keep it to be evenly distributed, thus direct blood circulation promoting.Therefore, Semen Ginkgo has significant protective effect to cardiovascular and central nervous system.In addition Folium Ginkgo also has the effects such as antiinflammatory, antiallergic, shock, antitumor.And clinical middle non-evident effect, be treat the desirable Chinese patent medicine preparation of Cardial or cerebral vascular diseases.Gingko leaf preparation is very safe.
Rhizoma Chuanxiong is used for pain in chest and hypochondrium, rheumatic arthralgia, and lump in the abdomen lumps, and skin infection swells and ache, and falls and flutters the pain of injury, menoxenia, amenorrhea dysmenorrhea, puerperal the disease such as stasis of blood pain.The pungent loose temperature of Rhizoma Chuanxiong is led to, function blood circulation promoting and blood stasis dispelling, and effect extensively, is applicable to the disease of various stagnation of blood stasis.The pungent perfume (or spice) of Rhizoma Chuanxiong is kind to be risen, and can push up on up head mountain peak, has wind-expelling pain-stopping effect, for controlling wind syndrome of head, headache key medicine, also can follow and what belonging to through carrying out suitable compatibility according to headache.In addition, clinical these product conventional treat angina pectoris in recent years.
Radix Notoginseng total arasaponins, Radix Salviae Miltiorrhizae, Folium Ginkgo, Rhizoma Chuanxiong can strengthen effect of blood circulation promoting and blood stasis dispelling after combining.The Chinese medicine composition with blood circulation invigorating efficacies provided by the invention, has good blood circulation promoting and blood stasis dispelling, effect of strengthening the body resistance, and energy blood vessel dilating, reduces blood fat amount and blood glucose amount, reduces blood viscosity, improves microcirculation; Thus change hemorheology, increase cerebrovascular and coronary flow; Improve cardiac diastolic function, improve Calcium and magnesium on myocardial cell sarcoplasmic reticulum, correct cardiac energy unbalance; And the activity of superoxide dismutase in cerebral tissue (SOD) can be improved, reduce the amount of lipid peroxide (LPO) and lipofuscin in cerebral tissue, there is stronger antioxidation, contribute to suppressing arteriosclerosis; This prescription is made preparation and is taken and can promote human body cell metabolism, improves the phagocytic activity of macrophage, enhancing human body immunity function.Concrete pharmacological action is as follows:
(1) function of resisting myocardial ischemia: Radix Notoginseng total arasaponins significantly can improve the ischemia performance of surface ecg; reduce myocardial infarct size; reduce the synthesis that LDH and a-TdR in cell infiltrates cytoprotective and safeguard DNA; reduce the release of CPK in cell; the generation of calcium gathering and MDA; improve the generation of SOD, the Left ventricular dilatation dysfunction of reversible angina of effort patient even can make it to recover normal.
(2) antiplatelet aggregative activity: Radix Notoginseng total arasaponins can suppress ADP, arachidonic acid, under platelet activating factor, colloid, thrombin induction, platelet aggregation, platelet T × A2 content can be made to decline, Ca2+ concentration significantly declines along with the increase of dosage, also collagen-induced platelet aggregation can be suppressed, its ZC50 is 0.185mg/mL and the amount of intra platelet free calcium 5-HT can be made to reduce CAMP content in platelet then obviously to increase, and prompting PNG and Radix Notoginseng alcohol glycosides wherein all have the antiplatelet aggregative activity of affirmative.
(3) blood viscosity, the effect for the treatment of coronary heart disease is reduced: have blood circulation promoting and blood stasis dispelling, nourishing blood and invigorating qi, also disappear also auxiliary dual regulation, effectively can reduce blood fat, cholesterol, vessel softening, regulate vasomotor centre, improve cardiac-cerebral ischemia anaerobic condition, improve body energy.
The effect that the present invention possesses and advantage:
The Chinese medicine composition with blood circulation invigorating efficacies provided by the invention, compatibility science, curative effect is obvious.There is blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, promote blood circulation active, change the effects such as turbid blood fat reducing, to various acute or chronic soft tissue injury, acute and chronic neck lumbar muscular injury, soft tissue of joint damage, cervical spondylosis, lumbar spondylosis, scapulohumeral periarthritis, tennis elbow, fracture etc., there is good easing pain and diminishing inflammation and Healing.For cardiovascular disease, there is suppressing the hyperactive liver and subsiding YANG, promoting blood circulation to remove obstruction in the collateral, enhancing immunologic function, endocrine regulation, promote the effects such as equilibrium between yin and yang.And there is the significant curative effects such as instant effect, relapse rate is low, safety is high, have no side effect, simple for production.
Accompanying drawing explanation
Fig. 1 is that the symptom of clinical treatment old cardiovascular disease group improves situation block diagram.
Detailed description of the invention
Illustrate content of the present invention further below in conjunction with embodiment, but protection scope of the present invention is not limited in these embodiments.
Embodiment 1
(1) by following mass parts feeding:
Radix Notoginseng total arasaponins 50 parts
Radix Salviae Miltiorrhizae 225 parts
Folium Ginkgo 225 parts
Rhizoma Chuanxiong 200 parts;
(2) Radix Salviae Miltiorrhizae in step (1), Rhizoma Chuanxiong, ginkgo leaf powder are broken into coarse powder, the Radix Notoginseng total arasaponins in step (1) is ground into fine powder; By solid-liquid mass ratio be 1 ︰ 6 add in Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Folium Ginkgo coarse powder mass concentration be 95% ethanol carry out reflux, extract, 1.5 hours, then filter; Again by solid-liquid mass ratio be 1 ︰ 5 add in filtering residue mass concentration be 50% ethanol carry out reflux, extract, 1 hour, then filter to obtain filtering residue; Merge the filtrate of twice reflux, extract, and reclaim ethanol and obtain ethanol extract;
(3) be that 1 ︰ 6 decocts with water 2 hours by step (2) gained filtering residue by solid-liquid mass ratio, filter and obtain decocting liquid; After step (2) gained ethanol extract and decocting liquid being merged, relative density when being concentrated into 50 DEG C is the thick paste of 1.40 again; Finally add in thick paste by the fine powder of gained Radix Notoginseng total arasaponins in step (2), mix homogeneously, adds appropriate customary adjuvant, makes the tablet for the treatment of cardiovascular and Orthopeadic Surgery disease by conventional method of the prior art, containing ginsenoside Rb in every sheet
1(C
54h
92o
23) 13.5mg, ginsenoside Rg must not be less than
1(C
42h
72o
14) 9.0mg, Panax Notoginseng saponin R must not be less than
1(C
47h
80o
18) must not 2.25mg be less than; And ginsenoside Rb
1, ginsenoside Rg
1, Panax Notoginseng saponin R
1total amount must not be less than 27.0mg.
Embodiment 2
(1) by following mass parts feeding:
Radix Notoginseng total arasaponins 30 parts
Radix Salviae Miltiorrhizae 250 parts
Folium Ginkgo 200 parts
Rhizoma Chuanxiong 150 parts;
(2) Radix Salviae Miltiorrhizae in step (1), Rhizoma Chuanxiong, ginkgo leaf powder are broken into coarse powder, the Radix Notoginseng total arasaponins in step (1) is ground into fine powder; By solid-liquid mass ratio be 1 ︰ 4 add in Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Folium Ginkgo coarse powder mass concentration be 95% ethanol carry out reflux, extract, 2 hours, then filter; Again by solid-liquid mass ratio be 1 ︰ 7 add in filtering residue mass concentration be 50% ethanol carry out reflux, extract, 0.5 hour, then filter to obtain filtering residue; Merge the filtrate of twice reflux, extract, and reclaim ethanol and obtain ethanol extract;
(3) be that 1 ︰ 4 decocts with water 3 hours by step (2) gained filtering residue by solid-liquid mass ratio, filter and obtain decocting liquid; After step (2) gained ethanol extract and decocting liquid being merged, relative density when being concentrated into 50 DEG C is the thick paste of 1.38 again; Finally add in thick paste by the fine powder of gained Radix Notoginseng total arasaponins in step (2), mix homogeneously, adds appropriate customary adjuvant, makes the capsule for the treatment of cardiovascular and Orthopeadic Surgery disease by conventional method of the prior art.
Embodiment 3
(1) by following mass parts feeding:
Radix Notoginseng total arasaponins 80 parts
Radix Salviae Miltiorrhizae 250 parts
Folium Ginkgo 250 parts
Rhizoma Chuanxiong 180 parts;
(2) Radix Salviae Miltiorrhizae in step (1), Rhizoma Chuanxiong, ginkgo leaf powder are broken into coarse powder, the Radix Notoginseng total arasaponins in step (1) is ground into fine powder; By solid-liquid mass ratio be 1 ︰ 8 add in Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Folium Ginkgo coarse powder mass concentration be 95% ethanol carry out reflux, extract, 1 hour, then filter; Again by solid-liquid mass ratio be 1 ︰ 3 add in filtering residue mass concentration be 50% ethanol carry out reflux, extract, 1.5 hours, then filter to obtain filtering residue; Merge the filtrate of twice reflux, extract, and reclaim ethanol and obtain ethanol extract;
(3) be that 1 ︰ 8 decocts with water 1 hour by step (2) gained filtering residue by solid-liquid mass ratio, filter and obtain decocting liquid; After step (2) gained ethanol extract and decocting liquid being merged, relative density when being concentrated into 50 DEG C is the thick paste of 1.35 again; Finally add in thick paste by the fine powder of gained Radix Notoginseng total arasaponins in step (2), mix homogeneously, adds appropriate customary adjuvant, makes the oral liquid for the treatment of cardiovascular and Orthopeadic Surgery disease by conventional method of the prior art.
Embodiment 4
(1) by following mass parts feeding:
Radix Notoginseng total arasaponins 60 parts
Radix Salviae Miltiorrhizae 220 parts
Folium Ginkgo 230 parts
Rhizoma Chuanxiong 190 parts;
(2) by the Radix Salviae Miltiorrhizae of step (1), Rhizoma Chuanxiong, Folium Ginkgo, decoct with water 2-3 time, filter to get filtrate and filtering residue, in filtrate, add Radix Notoginseng total arasaponins, the decoction of cardiovascular and Orthopeadic Surgery disease must be treated.
Get the tablet of above-described embodiment 1 gained treatment cardiovascular and Orthopeadic Surgery disease, treat for following clinical:
One, treatment target
1, cardiovascular disease group 1000 example, wherein: angina pectoris 200 example, dyspnea 200 example, coronary heart disease 200 example, hypertension and hyperlipidemia 200 example, myocardial infarction 200 example.
2, Orthopeadic Surgery disease group 500 example, wherein: acute soft tissue injury 90 example, fracture 60 example, 50 Cases of Chronic Soft Tissue Injury, Hypertrophic osteoarthritis 50 example, 50 Cases of Scapulohumeral Periarthritis, neck lumbar muscular injury 100 example, cervical spondylosis and lumbar spondylosis 100 example.
Two, instructions of taking
1, cardiovascular disease group everyone oral 2 at every turn, every day 3 times, serve on 21;
2, Orthopeadic Surgery disease group everyone oral 2 at every turn, every day 3 times, serve on 21.
Three, result
1, to the clinical efficacy of cardiovascular disease, its effective percentage is all more than 93%, and average effectiveness level reaches 96%, and wherein, angina pectoris reaches 98%, and myocardial infarction reaches 93.5%, and coronary heart disease reaches 95.2%, and dyspnea reaches 96%, and hypertension and hyperlipidemia reach 94.7%.Prove medicine provided by the invention, can effectively suppressing the hyperactive liver and subsiding YANG, promoting blood circulation to remove obstruction in the collateral, enhancing immunologic function, reduce blood fat, cholesterol, vessel softening, improves cardiac-cerebral ischemia anaerobic condition, improve body energy; Promptly can eliminate the symptom such as uncomfortable in chest, chest pain, dyspnea, the cardiopalmus of cardiovascular disease, dizzy headache, numb limbs and tense tendons.
2, to the clinical efficacy of Orthopeadic Surgery disease, total effective rate reaches 98%.Wherein, acute soft tissue injury cures 58 examples, effective percentage reaches 97%, and fracture effective percentage reaches 99%, and chronic soft tissue injuries cures 40 examples, effective percentage reaches 100%, Hypertrophic osteoarthritis effective percentage reaches 95%, and scapulohumeral periarthritis effective percentage reaches 95%, and neck lumbar muscular injury cures 80 examples, effective percentage reaches 97%, and cervical spondylosis and lumbar spondylosis effective percentage reach 96%.Prove medicine provided by the invention, there is blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, the effect such as to promote blood circulation active, also there is good easing pain and diminishing inflammation, accelerate the Healing of fracture and wound tissue.
Pass through observation on Clinical Application, the Chinese medicine composition with blood circulation invigorating efficacies provided by the invention, has good clinical efficacy at some important diseases such as treatment ischemic cerebrovascular, cerebral infarction, hyperlipidemia, coronary heart diseases and angina pectoris, the geriatric of vertebral-basal artery ischemia, blood high viscosity syndromes.
Four, conclusion
The Chinese medicine composition with blood circulation invigorating efficacies provided by the invention, there is the dissipating blood stasis hemostasis of Radix Notoginseng, reducing swelling and alleviating pain, softening the hard mass eliminate indigestion, outside the function of nourishing and fit keeping function, also has the promoting tissue regeneration by removing blood stasis of Radix Salviae Miltiorrhizae, promoting blood circulation to remove obstruction in the collateral, the function of relieving restlessness with all worries set aside and the clinical practice of Folium Ginkgo, in motherland's medical science, main blood circulation promoting and blood stasis dispelling, removing obstruction in the collateral to relieve pain, are astringed the lung and are relievingd asthma, change turbid fat-reducing effect.Clinical in diseases such as apoplectic hemiplegia, coronary heart disease, myocardial infarction, apoplectic hemiplegia and cough and asthma due to lung deficiency.The advantage such as there is good effect, application safety, have no side effect in clinical practice.The preparation method of this Chinese medicine composition is simple, and constant product quality is easy to use, is suitable for clinical application.Substantially the requirement of " safe, effective, quality controllable " is reached.
Claims (2)
1. treat a medicine for Orthopeadic Surgery disease, it is characterized in that crude drug is made up of the component of following masses part:
Radix Notoginseng total arasaponins 30 ~ 80 parts
Radix Salviae Miltiorrhizae 200 ~ 250 parts
Folium Ginkgo 200 ~ 250 parts
Rhizoma Chuanxiong 150 ~ 200 parts.
2. prepare the method for medicine described in claim 1, it is characterized in that through following each step:
(1) by following mass parts feeding:
Radix Notoginseng total arasaponins 30 ~ 80 parts
Radix Salviae Miltiorrhizae 200 ~ 250 parts
Folium Ginkgo 200 ~ 250 parts
Rhizoma Chuanxiong 150 ~ 200 parts;
(2) Radix Salviae Miltiorrhizae in step (1), Rhizoma Chuanxiong, ginkgo leaf powder are broken into coarse powder, be 1 ︰ 4 ~ 8 by solid-liquid mass ratio, add in Radix Salviae Miltiorrhizae, Folium Ginkgo, Rhizoma Chuanxiong coarse powder mass concentration be 95% ethanol carry out reflux, extract, 1 ~ 2 hour, filter to get filtrate and filtering residue; Be 1 ︰ 3 ~ 7 by solid-liquid mass ratio again, add in filtering residue mass concentration be 50% ethanol carry out reflux, extract, 0.5 ~ 1.5 hour, then filter to get filtrate and filtering residue; Merge the filtrate of twice reflux, extract, and reclaim ethanol and obtain ethanol extract;
(3) in step (2) gained filtering residue, be 1 ︰ 4 ~ 8 by solid-liquid mass ratio, decoct with water 1 ~ 3 hour, filter and obtain decocting liquid; After step (2) gained ethanol extract and decocting liquid being merged, relative density when being concentrated into 50 DEG C is the thick paste of 1.35 ~ 1.40 again; Finally Radix Notoginseng total arasaponins fine powder is added in thick paste, mix homogeneously, the medicine of the Orthopeadic Surgery disease that namely obtains medical treatment.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310420875.2A CN103432200B (en) | 2013-09-16 | 2013-09-16 | A kind of medicine for the treatment of Orthopeadic Surgery disease |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310420875.2A CN103432200B (en) | 2013-09-16 | 2013-09-16 | A kind of medicine for the treatment of Orthopeadic Surgery disease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103432200A CN103432200A (en) | 2013-12-11 |
| CN103432200B true CN103432200B (en) | 2016-03-09 |
Family
ID=49685985
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310420875.2A Active CN103432200B (en) | 2013-09-16 | 2013-09-16 | A kind of medicine for the treatment of Orthopeadic Surgery disease |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103432200B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110227111B (en) * | 2019-07-25 | 2022-03-25 | 文山郑保骨伤科医院 | Bone fracture powder with effects of promoting blood circulation, removing blood stasis, relieving swelling and pain |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101524421A (en) * | 2008-12-31 | 2009-09-09 | 江西本草天工科技有限责任公司 | Traditional Chinese medicine preparation for treating cardiovascular and cerebrovascular diseases |
| CN101612196A (en) * | 2009-08-18 | 2009-12-30 | 庞会心 | A kind of Chinese medicine composition and application thereof that prevents and treats cardiovascular and cerebrovascular disease |
| CN103083400A (en) * | 2013-03-01 | 2013-05-08 | 云南郡筹制药有限公司 | Drug for treating cardiovascular disease |
-
2013
- 2013-09-16 CN CN201310420875.2A patent/CN103432200B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101524421A (en) * | 2008-12-31 | 2009-09-09 | 江西本草天工科技有限责任公司 | Traditional Chinese medicine preparation for treating cardiovascular and cerebrovascular diseases |
| CN101612196A (en) * | 2009-08-18 | 2009-12-30 | 庞会心 | A kind of Chinese medicine composition and application thereof that prevents and treats cardiovascular and cerebrovascular disease |
| CN103083400A (en) * | 2013-03-01 | 2013-05-08 | 云南郡筹制药有限公司 | Drug for treating cardiovascular disease |
Non-Patent Citations (1)
| Title |
|---|
| 三七总皂苷的药理作用研究进展;甘雨;《时珍国医国药》;20071231;第18卷(第5期);1251-1252 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103432200A (en) | 2013-12-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103083400A (en) | Drug for treating cardiovascular disease | |
| CN113041293A (en) | Traditional Chinese medicine composition for treating atherosclerosis | |
| CN103623280B (en) | A kind of Chinese medicine preparation for the treatment of cardiovascular and cerebrovascular disease | |
| CN103041191A (en) | Traditional Chinese medicine composition for reducing blood pressure | |
| CN103432200B (en) | A kind of medicine for the treatment of Orthopeadic Surgery disease | |
| CN104083438A (en) | Balsam pear-containing traditional Chinese medicinal preparation for alleviating hypertension, and preparation method thereof | |
| CN101085233A (en) | Civil Chinese medicinal herb with hypotensive, antilipemic and hypoylycemic function | |
| CN105168713A (en) | Traditional Chinese medicine for treating migraine | |
| CN105412279A (en) | Blood-fat-reducing traditional Chinese medicine health care product | |
| CN102049010B (en) | Medicament for preventing and treating ischemic cerebrovascular diseases | |
| CN103860824A (en) | Pharmaceutical composition for treating fracture | |
| CN103393753B (en) | Traditional Chinese medicinal composition for treating cardiovascular and cerebrovascular diseases | |
| CN102343049A (en) | Chinese medicinal capsules for treating hypertension due to liver-yang hyperactivity | |
| CN106138831A (en) | A kind of Chinese medicine composition treating cardiovascular and cerebrovascular disease and preparation method thereof | |
| CN102327498A (en) | Novel anti-cancer medicament containing taxol extractum | |
| CN102266481B (en) | Chinese medicinal preparation for treating chronic cerebral circulation insufficiency | |
| CN105664030A (en) | Traditional Chinese medicine composition for improving cerebral small vessel disease cognition impairment and preparation method and application thereof | |
| CN101904891A (en) | Ginkgo leaf pills and preparation method thereof | |
| CN105169034A (en) | Traditional Chinese medicine composition for treating hypertension and preparation method thereof | |
| CN102423339A (en) | Drug for treating cadiovascular and orthopaedics diseases | |
| CN109771567A (en) | A kind of formula of Chinese herbal medicine supporting vital QI and dispersing blood stasis toxin expelling tumour | |
| CN102228567A (en) | Medicine for treating trigeminal neuralgia | |
| CN105687962A (en) | Electuary capable of treating atherosclerosis of coronary artery and preparation method thereof | |
| CN102716293A (en) | Capsule for treating hypertension, hyperlipemia, arteriosclerosis and coronary heart disease | |
| CN105663224A (en) | Composition for treating cardiovascular and cerebrovascular diseases and preparation thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |