CN110227111B - Bone fracture powder with effects of promoting blood circulation, removing blood stasis, relieving swelling and pain - Google Patents
Bone fracture powder with effects of promoting blood circulation, removing blood stasis, relieving swelling and pain Download PDFInfo
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Abstract
In order to solve the defects of the prior art, the invention provides bone fracture powder with the functions of promoting blood circulation, removing blood stasis, relieving swelling and pain, which is prepared by the following method: s1, preparing medicinal materials. S2, drying the prepared medicinal materials, and crushing the medicinal materials into fine powder according to the formula amount. And S3, sieving and uniformly mixing to obtain the bone fracture powder with the functions of promoting blood circulation, removing blood stasis, relieving swelling and pain. In part by mass, the medicinal materials in step S1 include: 300 portions of large-bonesetting pill 100-. The bone fracture powder prepared by the invention not only has good effect of curing bone fracture, but also has obvious effect of promoting blood circulation, removing blood stasis, relieving swelling and alleviating pain. And is suitable for large-scale production and use, has better curative effect on most people and has high total cure rate.
Description
Technical Field
The invention belongs to the technical field of external medicines, and particularly relates to bone fracture powder with the effects of promoting blood circulation, removing blood stasis, relieving swelling and pain.
Background
The earliest special monograph of traumatology in China exists: the eight methods of bone setting are taught in the secret prescription of xuan Zhishang Duan of Xian dynasty iris: touch, connect, hold, lift, tui, Na, an and M ó. The main symptoms of bone injury are: pain, swelling, dysfunction. The special signs are: tenderness, deformity, rubbing bone and empty glenoid cavity. Among them, the fracture healing process is divided into three stages, 1 hematoma organization stage, which takes about 2 weeks for the growth of fibrous junctions. 2 the callus formation stage, i.e. the fracture has reached the clinical healing stage, which takes about 2 months. 3, in the callus forming period, the marrow cavity is communicated again, and the process of recovering the original shape takes about 2 years. The callus formation period is also called as fracture rehabilitation period, natural healing or external medicines are mainly adopted in the prior art, but the effect is not obvious, particularly in the large-scale use process aiming at different crowds, the total cure rate is not high and is generally lower than 70%, and the effect is relatively single.
Disclosure of Invention
Aiming at the defects in the prior art, the invention provides bone fracture powder with the functions of promoting blood circulation, removing blood stasis, relieving swelling and pain, which is prepared by the following method:
s1, preparing medicinal materials.
S2, drying the prepared medicinal materials, and crushing the medicinal materials into fine powder according to the formula amount.
And S3, sieving and uniformly mixing to obtain the bone fracture powder with the effects of promoting blood circulation, removing blood stasis, relieving swelling and pain.
Further, the medicinal materials in step S1 include, in parts by mass: 300 portions of large-bonesetting pill 100-.
Further, the medicinal materials in step S1 include, in parts by mass: 250 portions of large-bonesetting pill, 180 portions of small-bonesetting pill, 180 portions of salvia miltiorrhiza, 180 portions of pseudo-ginseng, 70-90 portions of green grape and 150 portions of giant knotweed rhizome.
Further, in step S2, the drying is: drying the prepared medicinal materials in a constant temperature oven at 55-65 deg.C until the water content of the medicinal materials is less than 6%.
Further, in step S2, the pulverizing step is: the crushing operation is carried out in a low-temperature crusher.
Further, the crushing operation includes:
(1) replacing air environment in the crushing cabin with dry air, starting a crushing mechanism in the crusher at normal pressure, and crushing the medicinal materials in the crushing cabin for 3-5 min.
(2) On the basis of keeping the crushing mechanism running, the cabin filled with the medicinal materials in the crusher is pressurized, and the pressure in the cabin is increased to 2-3 atmospheric pressures within 2 min. Then the operation of the crushing mechanism and 2-3 atmospheric pressures in the cabin are maintained for 4-6 min.
(3) And (4) on the basis of stopping the operation of the crushing mechanism, the pressure in the crushing cabin is increased to the room pressure within 10-15 min.
Further, the cabin filled with the medicinal materials in the crusher is pressurized in the step (2), and mixed gas is adopted for carrying out the operation. The mixed gas comprises 3-5% of water vapor, 40-50% of carbon dioxide gas and the balance of nitrogen or air.
Further, the sieving in step S3 is: sieving with 80-120 mesh sieve, and collecting the filtered product as the target product. And collecting the sieved filter residue part, and returning the filter residue to a crushing cabin for re-crushing operation until the mass of the filter residue part is not more than 2% of the total mass of the batch of medicines.
Further, the re-crushing operation is: pulverizing under 2-3 atmospheric pressure in mixed gas environment for 5-10 min. The mixed gas comprises 60-70% of carbon dioxide gas and the balance of nitrogen.
Furthermore, the bone fracture powder with the functions of promoting blood circulation, removing blood stasis, relieving swelling and pain is determined by a hot dipping method under the alcohol soluble extract determination method, and the extract is not less than 16.0 percent.
The invention has at least one of the following advantages:
1. the bone fracture powder prepared by the invention not only has good effect of curing bone fracture, but also has obvious effect of promoting blood circulation, removing blood stasis, relieving swelling and alleviating pain.
2. The bone fracture powder is suitable for large-scale production and use, has a good cure effect on most people, and is high in overall cure rate.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is described in further detail below. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
Example 1
A bone fracture powder with the functions of promoting blood circulation, removing blood stasis, relieving swelling and pain is prepared by the following steps:
s1, preparing medicinal materials.
S2, drying the prepared medicinal materials, and crushing the medicinal materials into fine powder according to the formula amount.
And S3, sieving and uniformly mixing to obtain the bone fracture powder with the effects of promoting blood circulation, removing blood stasis, relieving swelling and pain.
In part by mass, the medicinal materials in step S1 include: 200 parts of large bone-knitting pill, 150 parts of small bone-knitting pill, 180 parts of salvia miltiorrhiza, 200 parts of pseudo-ginseng, 80 parts of green grape and 150 parts of giant knotweed.
The drying in step S2 is: drying the prepared medicinal materials in a constant temperature oven at 60 deg.C until the water content of the medicinal materials is less than 6%. The crushing in the step S2 is: the crushing operation is carried out in a low-temperature crusher.
The sieving in step S3 is: sieving with a 100-mesh sieve, and taking a filtered product as a target product. And collecting the sieved filter residue part, and returning the filter residue to a crushing cabin for re-crushing operation until the mass of the filter residue part is not more than 2% of the total mass of the batch of medicines.
The bone injury powder with the functions of promoting blood circulation, removing blood stasis, relieving swelling and pain is determined by a hot dipping method under the alcohol-soluble extract determination method, and the extract is not less than 16.0 percent.
Example 2
A bone fracture powder with the functions of promoting blood circulation, removing blood stasis, relieving swelling and pain is prepared by the following steps:
s1, preparing medicinal materials.
S2, drying the prepared medicinal materials, and crushing the medicinal materials into fine powder according to the formula amount.
And S3, sieving and uniformly mixing to obtain the bone fracture powder with the effects of promoting blood circulation, removing blood stasis, relieving swelling and pain.
In part by mass, the medicinal materials in step S1 include: 300 parts of large bonesetting pill, 200 parts of small bonesetting pill, 300 parts of salvia miltiorrhiza, 250 parts of pseudo-ginseng, 100 parts of green grape and 200 parts of giant knotweed.
The drying in step S2 is: drying the prepared medicinal materials in a constant temperature oven at 65 deg.C until the water content of the medicinal materials is less than 6%. The crushing in the step S2 is: the crushing operation is carried out in a low-temperature crusher.
The sieving in step S3 is: sieving with a 80-mesh sieve, and taking a filtered product as a target product. And collecting the sieved filter residue part, and returning the filter residue to a crushing cabin for re-crushing operation until the mass of the filter residue part is not more than 2% of the total mass of the batch of medicines.
The bone injury powder with the functions of promoting blood circulation, removing blood stasis, relieving swelling and pain is determined by a hot dipping method under the alcohol-soluble extract determination method, and the extract is not less than 16.0 percent.
Example 3
A bone fracture powder with the functions of promoting blood circulation, removing blood stasis, relieving swelling and pain is prepared by the following steps:
s1, preparing medicinal materials.
S2, drying the prepared medicinal materials, and crushing the medicinal materials into fine powder according to the formula amount.
And S3, sieving and uniformly mixing to obtain the bone fracture powder with the effects of promoting blood circulation, removing blood stasis, relieving swelling and pain.
In part by mass, the medicinal materials in step S1 include: 100 parts of large bonesetting pill, 100 parts of small bonesetting pill, 150 parts of salvia miltiorrhiza, 160 parts of pseudo-ginseng, 50 parts of green grape and 100 parts of giant knotweed.
The drying in step S2 is: drying the prepared medicinal materials in a 55 deg.C oven until the water content is less than 6%. The crushing in the step S2 is: the crushing operation is carried out in a low-temperature crusher.
The sieving in step S3 is: sieving with a 120-mesh sieve, and taking a filtered product as a target product. And collecting the sieved filter residue part, and returning the filter residue to a crushing cabin for re-crushing operation until the mass of the filter residue part is not more than 2% of the total mass of the batch of medicines.
The bone injury powder with the functions of promoting blood circulation, removing blood stasis, relieving swelling and pain is determined by a hot dipping method under the alcohol-soluble extract determination method, and the extract is not less than 16.0 percent.
Example 4
A bone fracture powder with the functions of promoting blood circulation, removing blood stasis, relieving swelling and pain is prepared by the following steps:
s1, preparing medicinal materials.
S2, drying the prepared medicinal materials, and crushing the medicinal materials into fine powder according to the formula amount.
And S3, sieving and uniformly mixing to obtain the bone fracture powder with the effects of promoting blood circulation, removing blood stasis, relieving swelling and pain.
In part by mass, the medicinal materials in step S1 include: 280 parts of large bonesetting pill, 180 parts of small bonesetting pill, 180 parts of salvia miltiorrhiza, 180 parts of pseudo-ginseng, 90 parts of green grape and 150 parts of polygonum cuspidatum.
The drying in step S2 is: drying the prepared medicinal materials in a constant temperature oven at 60 deg.C until the water content of the medicinal materials is less than 6%. The crushing in the step S2 is: the crushing operation is carried out in a low-temperature crusher.
The sieving in step S3 is: sieving with a 100-mesh sieve, and taking a filtered product as a target product. And collecting the sieved filter residue part, and returning the filter residue to a crushing cabin for re-crushing operation until the mass of the filter residue part is not more than 2% of the total mass of the batch of medicines.
The bone injury powder with the functions of promoting blood circulation, removing blood stasis, relieving swelling and pain is determined by a hot dipping method under the alcohol-soluble extract determination method, and the extract is not less than 16.0 percent.
Example 5
A bone fracture powder with the functions of promoting blood circulation, removing blood stasis, relieving swelling and pain is prepared by the following steps:
s1, preparing medicinal materials.
S2, drying the prepared medicinal materials, and crushing the medicinal materials into fine powder according to the formula amount.
And S3, sieving and uniformly mixing to obtain the bone fracture powder with the effects of promoting blood circulation, removing blood stasis, relieving swelling and pain.
In part by mass, the medicinal materials in step S1 include: 250 parts of large bone-knitting pill, 160 parts of small bone-knitting pill, 160 parts of salvia miltiorrhiza, 160 parts of pseudo-ginseng, 70 parts of green grape and 120 parts of giant knotweed.
The drying in step S2 is: drying the prepared medicinal materials in a constant temperature oven at 58 deg.C until the water content of the medicinal materials is less than 6%. The crushing in the step S2 is: the crushing operation is carried out in a low-temperature crusher.
The sieving in step S3 is: sieving with a 110-mesh sieve, and taking a filtered product as a target product. And collecting the sieved filter residue part, and returning the filter residue to a crushing cabin for re-crushing operation until the mass of the filter residue part is not more than 2% of the total mass of the batch of medicines.
The bone injury powder with the functions of promoting blood circulation, removing blood stasis, relieving swelling and pain is determined by a hot dipping method under the alcohol-soluble extract determination method, and the extract is not less than 16.0 percent.
Example 6
The bone fracture powder with the effects of promoting blood circulation, removing blood stasis, relieving swelling and pain as in any one of the embodiments 1-5 comprises the following crushing operations:
(1) the air environment in the crushing cabin is replaced by dry air, and a crushing mechanism in the crusher is started under normal pressure to crush the medicinal materials in the crushing cabin for 4 min.
(2) On the basis of keeping the operation of the crushing mechanism, the cabin filled with the medicinal materials in the crushing mechanism is pressurized, and the pressure in the cabin is increased to 2 atmospheric pressures within 2 min. Then the operation of the crushing mechanism and the 2-atmosphere pressure in the cabin are maintained for 5 min.
(3) After the operation of the crushing mechanism was stopped, the pressure in the crushing chamber was increased to the chamber pressure at 13 min.
Example 7
The bone fracture powder with the effects of promoting blood circulation, removing blood stasis, relieving swelling and pain as in any one of the embodiments 1-5 comprises the following crushing operations:
(1) the air environment in the crushing cabin is replaced by dry air, and a crushing mechanism in the crusher is started under normal pressure to crush the medicinal materials in the crushing cabin for 5 min.
(2) On the basis of keeping the operation of the crushing mechanism, the cabin filled with the medicinal materials in the crushing mechanism is pressurized, and the pressure in the cabin is increased to 3 atmospheric pressures within 2 min. Then, the operation of the crushing mechanism and the 3 atmospheric pressures in the cabin are maintained for 4 min.
(3) After the operation of the crushing mechanism was stopped, the pressure in the crushing chamber was brought to the chamber pressure in 15 min.
Example 8
The bone fracture powder with the effects of promoting blood circulation, removing blood stasis, relieving swelling and pain as in any one of the embodiments 1-5 comprises the following crushing operations:
(1) the air environment in the crushing cabin is replaced by dry air, and a crushing mechanism in the crusher is started under normal pressure to crush the medicinal materials in the crushing cabin for 3 min.
(2) On the basis of keeping the operation of the crushing mechanism, the cabin filled with the medicinal materials in the crushing mechanism is pressurized, and the pressure in the cabin is increased to 2 atmospheric pressures within 2 min. Then the operation of the crushing mechanism and the 2-atmosphere pressure in the cabin are maintained for 6 min.
(3) After the operation of the crushing mechanism was stopped, the pressure in the crushing chamber was brought to the chamber pressure within 10 min.
By adopting the crushing operation, the effective substances in the medicinal materials can be obviously overflowed to the outer layer, so that the efficacy of the medicinal powder is improved.
Example 9
Based on the bone fracture powder with the effects of promoting blood circulation, removing blood stasis, relieving swelling and pain in any embodiment of 6-8, the cabin filled with medicinal materials in the crusher is pressurized in the step (2), and the operation is carried out by adopting mixed gas. The mixed gas comprises 3-5% of water vapor, preferably 4%, 40-50% of carbon dioxide gas, preferably 45% and the balance of nitrogen or air.
The re-crushing operation is as follows: the pulverization is carried out under a mixed gas atmosphere of 2-3 atmospheres, preferably 2 atmospheres, for 5-10min, preferably 8 min. The mixed gas comprises 60-70% of carbon dioxide gas, preferably 65% of carbon dioxide gas and the balance of nitrogen gas.
The adoption of mixed air pressure for pressurization can absorb the frictional heat generated in the process of crushing the medicinal materials, play a role in reducing the temperature of the medicinal materials and avoid the inactivation of the effective components in the medicinal materials at high temperature. On the other hand, the oxidation inactivation of the effective components in the medicinal powder under the action of frictional heat can be effectively prevented. In addition, the fiber tissue of the medicinal powder can be softened, so that the active ingredients contained in the medicinal powder can be absorbed by human body when the medicinal powder is used, and the medicinal effect can be improved.
According to an embodiment of the invention, the bone fracture powder with the effects of promoting blood circulation, removing blood stasis, relieving swelling and pain is obtained by uniformly mixing after sieving in the step S3, and the product is obtained by subpackaging after being qualified through the following identification operations:
(1) taking 25g of the product, adding 100ml of methanol, heating and refluxing for 20 minutes, cooling, filtering, evaporating filtrate to dryness, adding 30ml of water into residue, slightly heating to dissolve, filtering, extracting filtrate with 25ml of water-saturated n-butanol, taking n-butanol solution, washing with 25ml of ammonia test solution, discarding ammonia solution, washing with 2 times of water-saturated n-butanol, 25ml each time, evaporating n-butanol solution to dryness, and adding 1ml of methanol to residue to dissolve to obtain a sample solution. Taking ginsenoside Rb1, ginsenoside Rg1 and notoginsenoside R1 as reference substances, adding methanol to obtain mixed solution containing 1mg of ginsenoside Rb1, ginsenoside Rg1 and notoginsenoside R1 per 1ml, and using as reference substance solution. According to a thin-layer chromatography (Chinese pharmacopoeia), 5-10 μ l of each of the two solutions is absorbed and respectively spotted on the same silica gel G thin-layer plate, a lower layer solution placed at the temperature of below 10 ℃ in chloroform-methanol-water (13: 7: 2) is used as a developing agent, the developing solution is taken out, dried in the air, sprayed with a 10% sulfuric acid ethanol solution, and heated at the temperature of 110 ℃ until spots are clearly developed. Spots of the same color appear in the chromatogram of the test solution at positions corresponding to those in the chromatogram of the control solution.
(2) Taking 6g of the product, adding 30ml of methanol, carrying out ultrasonic treatment (100W, frequency of 25kHz) for 30 minutes, filtering, evaporating filtrate to dryness, adding 20ml of 2.5mol/L sulfuric acid solution into residue, heating in water bath for 30 minutes, cooling, extracting with chloroform for 2 times, 20ml each time, combining chloroform solutions, evaporating to dryness, adding 1ml of chloroform into residue to dissolve, and taking the residue as a test solution. Another control medicinal material 0.5g is prepared, and the same method is used to prepare control medicinal solution. Then adding methanol into emodin and physcion reference substances to obtain solutions each containing 1mg per 1ml as reference substance solutions. According to a thin-layer chromatography (Chinese pharmacopoeia) test, absorbing 5-10 mul of each of the four solutions, respectively dropping the solution on the same silica gel G thin-layer plate, developing by using an upper-layer solution of petroleum ether (30-60 ℃) -ethyl formate-formic acid (15:5:1) as a developing agent, taking out, drying in the air, and inspecting under an ultraviolet lamp (365 nm). The test chromatogram shows fluorescent spots of the same color at the positions corresponding to those of the control chromatogram.
The clinical curative effect is summarized as follows:
5231 patients suffering from fracture, 209 patients suffering from soft tissue injury and 185 patients suffering from joint dislocation in 1-2016 (12-10-year in 2014, 5523 patients are treated by using the bone injury powder disclosed by the invention, and 16020 plaster prepared from the bone injury powder is used together; the total number of patients who use the bone injury powder is 10261, wherein the total number of patients who use the bone injury powder is 6016, the number of patients who suffer from soft tissue injury is 3100, the number of patients who suffer from lumbar muscle strain is 525, the number of patients who suffer from traumatic arthritis is 420, and the sequelae of fracture is 200. The observation and statistics of clinical curative effect and adverse reaction are carried out on 150 patients with bone fracture, 150 patients with soft tissue injury, 100 patients with lumbar muscle strain, 60 patients with traumatic arthritis and 60 patients with fracture sequelae, wherein the fracture patients and the soft tissue injury patients use the bone fracture medicine powder of the invention in the department of living, and the statistical results show that: the Zhengbao bone fracture medicinal liquor has the effects of activating blood circulation, removing stasis, relieving swelling and pain, the obvious effect rate of treating the fracture is 89.33 percent, and the total effective rate is 92.00 percent; 94.67 percent of obvious effect rate for treating soft tissue injury and 100.00 percent of total effective rate; 88.00 percent of obvious effect rate for treating lumbar muscle strain and 95.00 percent of total effective rate; the total effective rate of treating traumatic arthritis is 63.33%, and the significant efficiency is 78.33%; the obvious effect rate for treating the fracture sequelae is 66.67 percent, and the total effective rate is 80.00 percent. The using condition and the curative effect observation data are shown in tables 1 to 3.
TABLE 12014-2016 hospitalization use of the bone fracture powder of the invention statistical table
Table 22014-2016 outpatient service using the bone fracture medicine powder statistical table
TABLE 32014-2016 years Table for observing curative effect of the bone fracture medicine powder
Note: the significant efficiency is [ (number of cured cases + number of significant cases) ÷ total cases ] × 100%;
total effective rate [ (number of cure cases + number of effective cases) ÷ total number of cases ] × 100%
It is to be understood and appreciated that various changes and modifications can be made to the invention as described in detail above without departing from the spirit and scope of the invention as claimed. Accordingly, the scope of the claimed subject matter is not limited by any of the specific exemplary teachings provided.
Claims (6)
1. The preparation method of the external bone fracture powder with the functions of activating blood circulation, removing blood stasis, relieving swelling and pain is characterized by comprising the following steps:
s1, preparing medicinal materials;
s2, drying the prepared medicinal materials, and crushing the medicinal materials into fine powder according to the formula amount;
s3, sieving and mixing uniformly to obtain the external bone fracture powder with the functions of promoting blood circulation, removing blood stasis, relieving swelling and pain;
the medicinal materials in the step S1 comprise, by mass, 300 parts of large-bonesetting pill 100-;
the crushing in the step S2 is: in a low-temperature pulverizer;
the crushing operation comprises:
(1) replacing the air environment in the crushing cabin with dry air, starting a crushing mechanism in the crusher at normal pressure, and crushing the medicinal materials in the crushing cabin for 3-5 min;
(2) on the basis of keeping the operation of the crushing mechanism, pressurizing a cabin filled with medicinal materials in the crushing mechanism, and increasing the pressure in the cabin to 2-3 atmospheric pressures within 2 min; then the operation of the crushing mechanism and 2-3 atmospheric pressures in the cabin are maintained for 4-6 min;
(3) on the basis of stopping the operation of the crushing mechanism, reducing the pressure in the cabin of the crushing machine to room pressure within 10-15 min;
wherein, the crushing operation step (2) is to pressurize the cabin filled with the medicinal materials in the crusher and adopt mixed gas to perform the operation; the mixed gas consists of 3-5% of water vapor, 40-50% of carbon dioxide gas and the balance of nitrogen or air.
2. The preparation method of the external bone fracture powder with the effects of activating blood circulation, removing stasis, relieving swelling and alleviating pain as claimed in claim 1, wherein the medicinal materials in the step S1 comprise 280 parts by mass of Dajiegudan, 180 parts by mass of Xiaojiegudan, 180 parts by mass of Salvia miltiorrhiza Bunge, 180 parts by mass of Panax notoginseng Burk, 70-90 parts by mass of green grape and 150 parts by mass of Polygonum cuspidatum Bunge.
3. The method for preparing bone fracture powder for external use with effects of activating blood circulation to dissipate blood stasis, relieving swelling and alleviating pain as claimed in claim 1, wherein the drying in step S2 is: drying the prepared medicinal materials in a constant temperature oven at 55-65 deg.C until the water content of the medicinal materials is less than 6%.
4. The method for preparing bone fracture powder for external use with effects of activating blood circulation to dissipate blood stasis, relieving swelling and alleviating pain as claimed in claim 1, wherein the sieving in step S3 is: sieving with 80-120 mesh sieve, and collecting the filtered product as the target product; and collecting the sieved filter residue part, and returning the filter residue to a crushing cabin for re-crushing operation until the mass of the filter residue part is not more than 2% of the total mass of the medicine.
5. The method for preparing bone fracture powder for external use with effects of activating blood circulation to dissipate blood stasis, relieving swelling and pain as claimed in claim 4, wherein the regrinding operation is: pulverizing under 2-3 atmospheric pressure in mixed gas environment for 5-10 min; the mixed gas consists of 60-70% of carbon dioxide gas and the balance of nitrogen.
6. The method for preparing powder for bone fracture for external use with effects of promoting blood circulation, removing blood stasis, relieving swelling and pain as claimed in claim 1, wherein the powder for bone fracture for external use with effects of promoting blood circulation, removing blood stasis, relieving swelling and pain is not less than 16.0% extract measured by hot dipping method in alcohol-soluble extract measuring method.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN203264795U (en) * | 2013-04-02 | 2013-11-06 | 上海姚琴机械制造有限公司 | Power pressurizing quick-pulverizing machine |
| CN106729218A (en) * | 2017-02-16 | 2017-05-31 | 丁继昌 | Relaxing muscles and joints and promoting blood circulation dissipates |
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| CN1161140C (en) * | 2001-11-09 | 2004-08-11 | 天津天士力制药股份有限公司 | Medicine for preventing and treating coronary heart disease and angina pectoris and its prepn and other use |
| CN102423339A (en) * | 2011-12-10 | 2012-04-25 | 云南楚雄天利药业有限公司 | Drug for treating cadiovascular and orthopaedics diseases |
| CN103432200B (en) * | 2013-09-16 | 2016-03-09 | 云南楚雄天利药业有限公司 | A kind of medicine for the treatment of Orthopeadic Surgery disease |
| CN105343170A (en) * | 2015-11-20 | 2016-02-24 | 广西天天乐药业股份有限公司 | Traditional Chinese medicinal composition for treating extravasated blood impatency, and preparation method thereof |
| CN105343137A (en) * | 2015-12-16 | 2016-02-24 | 刘东波 | Gas explosion treatment of ganoderma spores |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN203264795U (en) * | 2013-04-02 | 2013-11-06 | 上海姚琴机械制造有限公司 | Power pressurizing quick-pulverizing machine |
| CN106729218A (en) * | 2017-02-16 | 2017-05-31 | 丁继昌 | Relaxing muscles and joints and promoting blood circulation dissipates |
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