CN117771340A - Composition for nourishing yin, clearing lung and relieving cough and preparation method thereof - Google Patents

Abstract

The invention relates to the technical field of foods, in particular to a composition for nourishing yin, clearing lung and relieving cough and a preparation method thereof. The composition mainly comprises 9 raw materials of longstamen onion bulb, lily bulb, bergamot pear, rhizoma polygonati, dried ginger, liquorice, shaddock, platycodon grandiflorum, dangshen and the like, and the preparation process adopts the technologies of crushing, low-temperature efficient extraction, centrifugation, membrane concentration and the like, and improves the release of active ingredients through an ultrasonic resonance technology. The traditional Chinese medicine composition provided by the invention adopts raw materials, all the raw materials complement each other, so that the effects of nourishing yin, moistening lung, relieving cough and clearing phlegm are achieved.

Description

Composition for nourishing yin, clearing lung and relieving cough and preparation method thereof

[ field of technology ]

The invention relates to the technical field of foods, in particular to a composition for nourishing yin, clearing lung and relieving cough and a preparation method thereof.

[ background Art ]

In autumn and winter, a series of respiratory symptoms are easily caused, and the daily life of people is still affected. The common symptoms of cough, asthma, excessive phlegm and the like are that some patients suffering from respiratory diseases for a long time are more concerned about the health condition of the patients, especially the weak population such as children and old people and the patients suffering from severe respiratory diseases. Therefore, the attention of respiratory symptoms has increased significantly, and people are more concerned about how to alleviate respiratory discomfort through daily healthcare.

In the theory of traditional Chinese medicine, the respiratory system is regarded as the "lung" of the human body, which is one of the organs that dominate the qi flow. The lung governs qi and breathing, and is important for normal physiological activities of the human body. Traditional Chinese medicine advocates improving yin-yang balance of the body by adjusting diet, life style and health care so as to enhance self-healing capacity of the body.

In the face of respiratory discomfort, an increasing number of people prefer to improve their health by routine maintenance. This transition in mind stems from the more active awareness of people's own health and trust in treatment of ill-conditioned therapies. It is increasingly recognized that the combination of herbs and traditional Chinese medical health concepts may provide a milder, comprehensive solution to respiratory problems. Therefore, people prefer to care the respiratory system carefully in daily life through diet, health-preserving drinks and the like to prevent and alleviate potential health problems.

In the current market, the traditional Chinese patent medicines are mainly used for preventing, treating or improving respiratory symptoms, and the beverage with the effects of moistening lung and relieving cough is very few, and meanwhile, certain limitations exist in the product, so that people feel unsatisfactory when seeking the support of comprehensive respiratory health. The disadvantages of these products are mainly manifested in a number of ways, one of which is: the traditional Chinese herbal medicine decoction method is generally adopted in the existing lung-moistening and cough-relieving beverage preparation process, and the traditional process has certain limitation; the traditional method has a certain influence on the enzyme activity in the raw material, so that the stability of the product is poor, and precipitation and turbidity are easy to occur. Aiming at the technical problems that the current market lacks drinks/soup with lung moistening and cough relieving effects aiming at respiratory symptoms, the current soup drink preparation technology is not ideal, and the product stability is poor, a drink with lung moistening and cough relieving effects needs to be developed.

[ invention ]

The invention aims at: aiming at the problems in the background technology, the composition for nourishing yin, clearing lung and relieving cough is provided, the raw materials supplement each other, the composition has the effects of nourishing yin, moistening lung, relieving cough and clearing phlegm, accords with the formula principle of monarch, minister, assistant and guide in traditional Chinese medicine, comprehensively conditions the respiratory system, and provides mild and comprehensive health care support.

In order to achieve the above purpose, the technical scheme adopted by the invention is as follows:

a composition for nourishing yin, clearing lung and relieving cough comprises the following components in parts by weight: 2-7 parts of allium macrostemon, 25-40 parts of bergamot pear, 3-12 parts of grapefruit, 13-20 parts of lily, 12-25 parts of rhizoma polygonati, 1-4 parts of dried ginger, 2-5 parts of liquorice, 2-7 parts of platycodon grandiflorum and 0.01-0.1 part of radix codonopsis.

The invention provides a composition for nourishing yin, clearing lung and relieving cough, which comprises the following components:

monarch drug-lily bulb and rhizoma polygonati (main drug): lily is sweet and cold in nature and enters heart and lung meridians. Has effects of nourishing yin, moistening lung, clearing heart fire, and tranquilizing; polygonatum sibiricum is sweet and flat in nature, enters lung, spleen and kidney meridians, has the effects of strengthening spleen, moistening lung and tonifying kidney, and is compatible with the lung meridian, so that symptoms such as dry cough, little phlegm, dry mouth, dry throat, red tongue, little tongue coating and the like caused by lung yin deficiency are improved.

Ministerial drug-bergamot pear and shaddock (assisting and strengthening monarch drug effect): bergamot pear is sweet and cold in nature, enters lung and stomach channels, and has the effects of promoting fluid production, moistening dryness, clearing lung and eliminating phlegm; the pomelo has bitter and cold nature, enters lung and spleen channels, and has the effects of regulating qi, resolving phlegm, lowering adverse qi and relieving cough; all the flavors moisten the lung together. In addition, the unique flavor substances of the bergamot pears and the grapefruits are helpful for improving the freshness and flavor of the beverage.

Adjuvant drug-dangshen and platycodon root (adjuvant drug): dang Shen is sweet and calm, enters spleen and lung meridians. Strengthening the spleen, tonifying the lung, nourishing blood and promoting the production of body fluid, and is particularly suitable for chronic cough caused by deficiency of spleen-lung qi. Ji Geng is pungent and sweet in nature, and is indicated for lung meridian. Has effects in dispersing lung qi, relieving sore throat, eliminating phlegm, expelling pus, regulating lung qi, and relieving phlegm retention.

Adjuvant drug-dried ginger, allium macrostemon (adjuvant drug): the dry Jiang Xingwei is pungent and warm, enters lung, spleen and stomach meridians, has the effects of warming lung to dispel cold, resolving phlegm and relieving cough, and is helpful for relieving cold evil. The allium macrostemon is pungent, bitter and warm in nature, enters heart, lung, stomach and large intestine meridians, has the effects of regulating qi-flowing, resolving phlegm, promoting qi circulation and resolving depression, and is beneficial to relieving pulmonary discomfort.

Radix Glycyrrhizae (harmonizing the ingredients): licorice is sweet in nature, flat in taste, enters lung, heart, spleen and stomach meridians, has the effects of tonifying middle-jiao and Qi, regulating middle-jiao and eliminating phlegm, and harmonizes the actions among all the medicines.

The preparation method of the composition for nourishing yin, clearing lung and relieving cough comprises the following steps:

A. pulverizing Bulbus Lilii, radix Codonopsis, radix Platycodi, rhizoma Zingiberis, bulbus Allii Macrostemi, and Glycyrrhrizae radix by dry method, sieving with 0.8-3mm sieve to obtain mixed powder;

B. adding 3 times of water into rhizoma Polygonati, fructus Pyri and fructus Citri Grandis, wet pulverizing, and sieving with 0.8-3mm sieve to obtain mixed fine powder slurry;

C. extracting the mixed powder and the mixed fine pulp by low-temperature high-efficiency extraction complete equipment, centrifuging the extracting solution at a high speed, carrying out microfiltration treatment on the centrifugate by adopting a tubular ceramic membrane, carrying out membrane concentration on the obtained filtrate by using a coiled composite membrane to obtain concentrated solution, and sterilizing to obtain the composition for nourishing yin, clearing lung and relieving cough.

In an optimized scheme, the solid content of the concentrated solution is 10-20%.

The optimized scheme is that the temperature is controlled to be less than or equal to 30 ℃ in the low-temperature efficient extraction process so as to retain the effective components in the raw materials; the extraction pressure of the low-temperature high-efficiency extraction is 26-34MPa, and the high pressure is 30-40MPa.

In a further optimized scheme, the water adopted in wet crushing is chilled water, and the temperature T of the chilled water is less than or equal to 5 ℃.

In a further preferred embodiment, the high-speed centrifugation has a frequency of 45HZ.

In a further optimized scheme, an ultrasonic resonance technology is introduced into the extracting solution before the extracting solution is centrifuged, wherein specific parameters of the ultrasonic resonance technology are set to be 200W in power, 30 minutes in time and 20kHz in frequency.

According to a further optimized scheme, the solid content of the composition for nourishing yin, clearing lung and relieving cough is more than or equal to 13%.

In a further optimized scheme, the Brix value of the tube type ceramic membrane for microfiltration is less than 3.0%, and the Brix value of the coiled composite membrane for membrane concentration is 0.5-14%.

In summary, due to the adoption of the technical scheme, the beneficial effects of the invention are as follows:

according to the formula principle of monarch, minister, assistant and guide, the yin-nourishing lung-heat-clearing cough-relieving composition is prepared by reasonably proportioning raw materials such as lily, rhizoma polygonati, dangshen, platycodon grandiflorum, dried ginger, liquorice, allium macrostemon, bergamot pear and pomelo, applying a high-efficiency high-pressure-difference low-temperature continuous extraction separation technology, and performing processes such as high-speed centrifugation, ceramic membrane microfiltration and membrane concentration, has the effects of nourishing yin, moistening lung, relieving cough and clearing phlegm, and is especially suitable for dry cough patients without phlegm and with little phlegm.

The water adopted in the wet crushing is chilled water, the temperature T of the chilled water is less than or equal to 5 ℃, and a low-temperature efficient extraction technology is adopted, so that the temperature is controlled to be less than or equal to 30 ℃ in the extraction process, and active ingredients in raw materials are reserved to the greatest extent. The method is not only beneficial to improving the bioavailability of the product, but also effectively avoids adverse effects on the activity of enzymes in raw materials in the traditional preparation process, avoids the treatment method of enzyme killing and glycoside protecting after the activity of plant enzymes is excited in the traditional preparation process, and ensures that the obtained product has stable quality and can not generate sediment and turbidity in a holding period.

An ultrasonic resonance technology is introduced into the extracting solution, and the micro-motion mechanical effect in the liquid phase is increased through the action of ultrasonic waves, so that the release and the dissolution of beneficial components in the raw material are effectively promoted, the concentration of active components in the extracting solution is improved, and the release and the dissolution of the beneficial components in the raw material are improved. The specific parameters of the technology are set to be 200W in power, 30 minutes in time and 20kHz in frequency, so that the high efficiency and stability of extraction are ensured.

Realizing the effects of comprehensively moistening lung and relieving cough. Each component is carefully selected to provide synergy under the guidance of the theory of traditional Chinese medicine, providing more comprehensive respiratory health support.

[ description of the drawings ]

FIG. 1 specific experimental HPLC chromatogram

FIG. 2 example 8 test sample and standard fingerprint of composition for nourishing yin, clearing lung-heat and relieving cough.

[ detailed description ] of the invention

The invention is further illustrated below with reference to examples.

Example 1

A composition for nourishing yin, clearing lung and relieving cough comprises the following components in parts by weight: 13 parts of lily, 12 parts of rhizoma polygonati, 1 part of dried ginger, 2 parts of liquorice, 2 parts of allium macrostemon, 25 parts of bergamot pear, 3 parts of pomelo, 0.01 part of radix codonopsis and 2 parts of platycodon grandiflorum.

Example 2

A composition for nourishing yin, clearing lung and relieving cough comprises the following components in parts by weight: 20 parts of lily, 25 parts of rhizoma polygonati, 4 parts of dried ginger, 5 parts of liquorice, 7 parts of allium macrostemon, 40 parts of bergamot pear, 12 parts of pomelo, 0.1 part of radix codonopsis and 7 parts of platycodon grandiflorum.

Example 3

A composition for nourishing yin, clearing lung and relieving cough comprises the following components in parts by weight: 15 parts of lily, 14 parts of rhizoma polygonati, 2 parts of dried ginger, 3 parts of liquorice, 3 parts of allium macrostemon, 35 parts of bergamot pear, 6 parts of pomelo, 0.03 part of radix codonopsis and 3 parts of platycodon grandiflorum.

Example 4

A method for preparing a composition of examples 1-3 for nourishing yin, clearing lung-heat and relieving cough, comprising the steps of:

A. pulverizing Bulbus Lilii, radix Codonopsis, radix Platycodi, rhizoma Zingiberis, bulbus Allii Macrostemi, and Glycyrrhrizae radix by dry method, sieving with 0.8-3mm sieve (0.8 mm sieve or any sieve of 0.8-3mm in this embodiment) to obtain mixed powder;

B. adding 3 times of water into rhizoma Polygonati, fructus Pyri and fructus Citri Grandis respectively, wet pulverizing, sieving with 0.8-3mm sieve (1.2 mm sieve or 0.8-3mm sieve in this example) to obtain mixed fine powder slurry;

C. extracting the mixed powder and the mixed fine pulp through low-temperature efficient extraction complete equipment, centrifuging the extracting solution at a high speed, carrying out microfiltration treatment on the centrifugate by adopting a tubular ceramic membrane, and concentrating the obtained filtrate by using a coiled composite membrane to obtain a concentrated solution, wherein the concentration solution is concentrated to a liquid-material ratio of 1:1.8, the composition for nourishing yin, clearing lung and relieving cough is obtained.

The temperature is controlled to be less than or equal to 30 ℃ in the low-temperature efficient extraction process so as to retain the effective components in the raw materials; extracting at low temperature and high efficiency under 26-34MPa, 30-40MPa and 20-30MPa.

The water adopted in wet crushing is chilled water, and the temperature T of the chilled water is less than or equal to 5 ℃.

The frequency of high speed centrifugation was 45HZ.

The Brix value of the tube type ceramic membrane for microfiltration is less than 3.0, and the Brix value of the roll type composite membrane for membrane concentration is 0.5-14%.

Example 5

The rest of the procedure is as in example 4, and an ultrasonic resonance technique is introduced into the extract before the centrifugation of the extract, the specific parameters of the ultrasonic resonance technique being set to 200W for 30 minutes at a frequency of 20kHz.

Example 6

Pulverizing Bulbus Lilii, radix Codonopsis, radix Platycodi, zingiberis rhizoma, bulbus Allii Macrostemi, glycyrrhrizae radix, fructus Citri Grandis, rhizoma Polygonati, and fructus Pyri in the composition of example 3, soaking for 30min with 10 times of water, heating, boiling for 30min, filtering, keeping filtrate for use, heating the residue with 8 times of water, boiling for 30min, and filtering; heating the residue with 8 times of water, boiling for 30min, filtering, and mixing the filtrates; evaporating and concentrating the filtrate at 90 ℃ until the liquid-material ratio is 1:1.8 Filtering with 200 mesh filter screen, and sterilizing to obtain the control sample of example 6.

Example 7

Taking the proportion of the compositions in examples 1-3 respectively, and preparing according to the preparation method of example 4 to obtain samples of examples 1-3 respectively; prepared by the method of example 5 using the composition ratio of example 3, obtaining samples of example 5, respectively; the sample prepared in example 6 was the control sample of example 6.

Solid content test

Samples of examples 1-6 were taken for solids content and product quality stability testing, and 100ml samples were taken in parallel for 3 times for solids content testing, respectively. The solid content of the concentrate was measured by a conventional method, the data was averaged, and the experimental results are shown in table 1.

TABLE 1 solids content of concentrate

Sample of	Solid content (%)
		Example 1 sample	13.4
Example 2 sample	14.2
		Example 3 sample	13.8
Example 5 sample	15.6
		Example 6 control sample	12.3

Accelerated test of product quality stability

The long-term storage condition is simulated, and the quality stability of the composition for nourishing yin, clearing lung and relieving cough is accelerated to be evaluated so as to predict the possible quality change condition in the two-year shelf life.

The samples were all placed in a high temperature and high humidity environment to accelerate the aging process of the samples by increasing the temperature and humidity.

Test conditions: temperature: the sample was placed in an incubator at 37 ℃. Humidity: the sample was placed in a high humidity environment with a relative humidity of 75%; and the storage is carried out for 3 months under the condition of avoiding direct light.

Test time: continuous acceleration tests were performed to observe quality changes at various time points, including 0 days, 1 month, 2 months, and 3 months.

The experimental results are shown in Table 2.

TABLE 2 accelerated test results of quality stability

Example 5 the sample had very little change in overall appearance, suspended matter and solids precipitation due to the use of ultrasonic resonance techniques and was relatively stable in quality. The samples of examples 1, 2, 3 have similar tendencies in terms of color, suspended matter and solids precipitation, but may show slight variations at 3 months, and may require further optimization of the process. Example 6 control samples were relatively unstable in quality due to the conventional poaching process, with large changes in color, suspended solids and solid precipitation.

Example 8

Standard fingerprint comparison test

And (3) equipment: shimadzu LC-10AT high performance liquid chromatograph

Reagent: acetonitrile (chromatographic purity, di ma company, usa), phosphoric acid (analytical purity, chengdu, kelong chemical reagent company), rutin (Beijing instrumentation and general labeling technology Co., ltd., lot number 17031501), glycyrrhizic acid (China medicine biosystems, lot number 100080-200306), naringin (China medicine biosystems, lot number 111538-200504), and primary water.

Sample: taking the sample (No. 1) of the example 3, the sample (No. 2) of the example 5 and the control sample (No. 3) of the example 6, taking 60g of lily lung fixing sample in an evaporation bottle, concentrating by rotary evaporation at the water bath temperature of 60-70 ℃, cooling after concentrating, placing in a 50mL volumetric flask, placing in an ultrasonic wave instrument for 30min, taking out, placing to room temperature, and fixing the volume by using a methanol solution to obtain the lily lung fixing liquid.

Preparation of a control solution: respectively precisely weighing appropriate amounts of rutin, glycyrrhizic acid and naringin reference substances, dissolving in methanol to constant volume in a 10mL volumetric flask, and respectively preparing a rutin reference substance containing 0.1234mg per 1mL, a glycyrrhizic acid reference substance containing 0.1303mg per 1mL and a naringin reference substance containing 0.0673mg per 1mL by adopting methanol to constant volume in the embodiment.

The chromatographic conditions were determined as: and (3) equipment: the Shimadzu LC-10AT high performance liquid chromatograph adopts a Platisil 5 mu m ODS (250 mm multiplied by 4.6mm,5 mu m) chromatographic column, uses acetonitrile (A) -0.3% phosphoric acid water (B) solution as mobile phase to carry out gradient elution, the flow rate is 1mL/min, the wavelength is 280nm, the sample injection amount is 10 mu L, and the column temperature is 25 ℃; the elution procedure was condition 6, see in particular table 3:

TABLE 3 gradient elution conditions for mobile phases

The chromatogram similarity is analyzed by software of a traditional Chinese medicine chromatographic fingerprint similarity evaluation system (2012 edition), and the standard fingerprint of the composition for nourishing yin, clearing lung and relieving cough is a common mode control spectrum of the composition for nourishing yin, clearing lung and relieving cough, which is established in the previous study, and the common mode control spectrum and the specificity investigation control spectrum are shown in figure 1. From the results, it is known that:

2,4,5,7,8, peak No. 11 is assigned to lily;

10 Peaks No. 12, 13 are ascribed to grapefruit;

peak No. 9, 14 was assigned to licorice;

peak No. 15 belongs to dried ginger;

the No. 5 peak is the common peak of lily, platycodon grandiflorum and allium macrostemon.

The relative retention time and the relative peak area of the common peak of each batch of samples are shown in tables 4 and 5, the similarity of chromatograms is shown in table 6, and the spectrum comparison of each sample and the standard fingerprint is shown in figure 2. The results show that the RSD of the samples of the embodiment 3 and the sample of the embodiment 5 is less than or equal to 5 percent of the relative retention time, the RSD of the relative peak area is less than or equal to 5 percent, the peak-out time of each common peak is stable, the characteristics of the fingerprint are provided, the fingerprint can be preliminarily formulated as index component groups of the beverage for nourishing yin, clearing lung and relieving cough, the product quality is qualified, the similarity of the chromatograms is above 0.9, and the fingerprint meets the technical requirements of the fingerprint. But the relative retention time of the control sample of the embodiment 6 adopting different preparation processes is more than or equal to 5 percent, the relative peak area is more than or equal to 5 percent, the chromatogram similarity is less than 0.9, the quality of the product cannot reach the factory standard of enterprises, the content of the effective components is greatly different, and the production process influences the final quality of the product even though the raw materials of the product are the same. TABLE 4 relative retention time of each common peak for different samples

TABLE 5 relative peak areas for various samples

TABLE 6 evaluation of finger print similarity of different samples

Example 9 Effect test

1. Diagnostic criteria

(1) Inclusion criteria

All the research cases are included according to the traditional Chinese medicine disease diagnosis curative effect standard and the cough diagnosis and treatment guide (2015). Inclusion criteria: 18-75 years old; cough time > 3 weeks; coughing induced by paroxysmal itching of the throat is a typical symptom; no obvious lesions were seen in chest X-ray examination.

(2) Exclusion criteria

Cough with drug origin; with obvious symptoms of shortness of breath, dyspnea, hemoptysis, fever, etc., or obvious lesions of pneumonia, bronchitis changes, etc. found by chest X-ray examination.

2. Test method

The cases are 300 cases of cough with laryngeal origin due to yin deficiency and lung dryness. The patients are divided into six groups by adopting a random number table method, 150 cases are adopted in the embodiment, 30 cases are adopted for men and 20 cases are adopted for women; age 36-69 years, average 51.07 + -6.76 years; example 250, 28 men and 22 women; age 35-66 years, average 50.54+ -7.01 years old; example 350, 29 men and 21 women; ages 37-65 years, average 50.67 + -7.38 years; example 550, 33 men and 17 women; age 39-71 years, average 55.56+ -6.35 years; example 650, 29 men and 21 women; age 38-66 years, average 53.87 + -7.77 years; control group 50, 30 men and 20 women; ages 43-67, average 53.11 + -7.34 years. The clinical trial notification is perfected, so that patients and families can be fully aware of the traditional Chinese and western medicine treatment method of the study, the conventional nursing measures of the disease and the like, and all sign informed consent under the fully voluntary condition. The sex and age differences of the two groups of patients are not statistically significant (P > 0.05), and the patients are comparable.

The control group was taken orally with 30mg of dextromethorphan tablet, tid. The observation group adopts the concentrated solution composition prepared by each example for treatment, the prescription is shown in the example, the administration dosage is 40g, tid, and the oral administration is carried out. The treatment course was 1 treatment course over 4 weeks, and the total observation was 4 weeks.

3. Evaluation of efficacy

The curative effect evaluation is carried out by referring to the diagnosis standards in the clinical study guidelines (trial) of new traditional Chinese medicine and the diagnosis curative effect standard of traditional Chinese medicine symptoms.

Clinical control: the clinical symptoms disappear or basically disappear, the main symptom score is 0, and the reduction is more than or equal to 80.0% compared with the treatment before treatment;

the effect is shown: the clinical symptoms are obviously improved, and the integral of the main symptoms is reduced by 66.7 to 80 percent compared with that before treatment;

the method is effective: clinical symptoms are reduced, and the integral of main symptoms is reduced by 33.3 to 66.7 percent compared with that before treatment;

invalidation: the clinical symptoms are not obviously improved or aggravated, and the integral of the main symptoms is reduced by less than 33.3 percent compared with the integral of the main symptoms before treatment.

4. Statistical methods: data processing was performed using statistical software SPSS 20.0. The count data is described in terms of rate (%), χ is used ² Checking and analyzing; metering data toDescribed and analyzed using a t-test method. The difference was statistically significant with P < 0.05.

5. Therapeutic effects

Table 7 comparison of the efficacy of patients in each group

Note that: compared with the control group, the value of the #P is less than 0.05

Table 8 cough score comparison for each group of patientsDividing into two parts

Group of	Number of examples	Before treatment	After treatment
				Example 1	50	3.50±1.29	1.96±1.43*#
Example 2	50	3.49±1.40	1.90±1.32*#
				Example 3	50	3.51±1.33	1.95±1.15*#
Example 5	50	3.58±1.30	1.85±1.30*#
				Example 6	50	3.66±1.51	2.50±1.45*#
Control group	50	3.48±1.22	2.55±1.22*

Note that: p < 0.05 compared to pre-treatment; in comparison with the control group, #P < 0.05.

TABLE 9 LCQ integral comparison for two groups of patientsDividing into two parts

Note that: p < 0.05 compared to pre-treatment; in comparison with the control group, #P < 0.05.

6. Adverse reactions

In the study, adverse reactions did not occur in each example, and the control group had 2 cases of adverse reactions with dizziness and headache.

The foregoing description is directed to the preferred embodiments of the present invention, but the embodiments are not intended to limit the scope of the invention, and all equivalent changes or modifications made under the technical spirit of the present invention should be construed to fall within the scope of the present invention.

Claims (9)

1. The composition for nourishing yin, clearing lung and relieving cough is characterized by comprising the following components in parts by weight: 2-7 parts of allium macrostemon, 25-40 parts of bergamot pear, 3-12 parts of grapefruit, 13-20 parts of lily, 12-25 parts of rhizoma polygonati, 1-4 parts of dried ginger, 2-5 parts of liquorice, 2-7 parts of platycodon grandiflorum and 0.01-0.1 part of radix codonopsis.

2. A method of preparing the yin nourishing lung heat clearing and cough relieving composition as claimed in claim 1, comprising the steps of:

A. pulverizing Bulbus Lilii, rhizoma Zingiberis, bulbus Allii Macrostemi, glycyrrhrizae radix, radix Platycodi, and radix Codonopsis by dry method, sieving with 0.8-3mm sieve to obtain mixed powder;

B. adding 3 times of water into rhizoma Polygonati, fructus Pyri and fructus Citri Grandis, wet pulverizing, and sieving with 0.8-3mm sieve to obtain mixed fine powder slurry;

C. extracting the mixed powder and the mixed fine pulp by low-temperature efficient extraction complete equipment, wherein the total water consumption for extraction is 19 times of that of the dry materials, centrifuging the extracting solution at high speed, carrying out microfiltration treatment on the centrifugate by adopting a tubular ceramic membrane, and carrying out membrane concentration on the obtained filter liquor by using a coiled composite membrane to obtain a concentrated solution, namely the composition for nourishing yin, clearing lung and relieving cough.

3. The method for preparing the composition for nourishing yin, clearing lung and relieving cough according to claim 2, wherein the temperature is controlled to be less than or equal to 30 ℃ in the low-temperature efficient extraction process so as to retain the effective components in the raw materials; the extraction pressure of the low-temperature high-efficiency extraction is 26-34MPa, and the high pressure is 30-40MPa.

4. The method for preparing the composition for nourishing yin, clearing lung and relieving cough according to claim 2, wherein the water adopted in the wet crushing is chilled water, and the temperature T of the chilled water is less than or equal to 5 ℃.

5. The method for preparing a composition for nourishing yin, clearing lung and relieving cough according to claim 2, wherein the frequency of the high-speed centrifugation is 45HZ.

6. The method for preparing the composition for nourishing yin, clearing lung and relieving cough according to claim 2, wherein an ultrasonic resonance technology is introduced into the extracting solution before the extracting solution is centrifuged, and specific parameters of the ultrasonic resonance technology are set to be 200W, 30 minutes and 20kHz.

7. The method for preparing a composition for nourishing yin, clearing lung and relieving cough according to claim 2, wherein the solid content is more than or equal to 13%.

8. The method for preparing the composition for nourishing yin, clearing lung and relieving cough according to claim 2, wherein the Brix value of the tube type ceramic membrane for microfiltration is less than 3.0%, and the Brix value of the roll type composite membrane for membrane concentration is 0.5-14%.

9. The method for preparing a composition for nourishing yin, clearing lung and relieving cough according to claim 8, wherein the solid content of the concentrated solution is 10-20%.