CN116509971A

CN116509971A - Traditional Chinese medicine formula, traditional Chinese medicine liquid and medicinal preparation with intelligence improving effect

Info

Publication number: CN116509971A
Application number: CN202310657436.7A
Authority: CN
Inventors: 刘远平; 刘儒达
Original assignee: Individual
Current assignee: Individual
Priority date: 2023-06-05
Filing date: 2023-06-05
Publication date: 2023-08-01

Abstract

The invention discloses a traditional Chinese medicine formula, traditional Chinese medicine liquid and a pharmaceutical preparation with an intelligence improving effect, which are prepared from the following raw material medicines: chinese angelica, polygala tenuifolia, dried rehmannia root, semen cuscutae, shizandra berry, grassleaf sweetflag rhizome, dragon bone, szechuan lovage rhizome, cortex lycii radicis, chinese olive, fructus terminaliae bellae, emblic leafflower fruit, common anemarrhena rhizome, rhodiola root, american ginseng, liquorice, indian buead, spina date seed, chinese angelica, lucid ganoderma, cortex albiziae, lily, chinese yam, platycladi seed, glossy privet fruit, red sage root, radix sophorae flavescentis, rhizoma polygonati, oyster, longan pulp, tortoise shell glue and fructus alpiniae oxyphyllae, and the special formula is carefully matched to mainly treat amnesia and enhance memory according to the formula principle of ' monarch, minister, assistant and guide's theory ' of traditional Chinese medicine; improving cerebral blood and oxygen supply, resisting fatigue and hypoxia, improving learning concentration, improving phenomenon of learning concentration failure, and improving stress capability of organism; has effects of invigorating heart and kidney, improving intelligence, and tranquilizing mind, and can be used for treating amnesia, listlessness, delayed reaction , and insomnia caused by incoordination between heart and kidney; through long-term clinical verification, the efficacy is clinically verified.

Description

Traditional Chinese medicine formula, traditional Chinese medicine liquid and medicinal preparation with intelligence improving effect

Technical Field

The invention relates to the field of traditional Chinese medicine foods and health care products, in particular to a traditional Chinese medicine formula, traditional Chinese medicine liquid and a pharmaceutical preparation with an intelligence improving effect.

Background

Children and teenagers are the future of families and society, while intelligence is one of the most important elements in the growth and development of the children and teenagers, and is the most interesting thing of each family. Learning ability is the ability to acquire and use knowledge, and is a comprehensive representation of various abilities such as perception, cognition, self-control ability, understanding, memory, operation ability and the like.

The learning ability is more related to intelligence and reaction ability, the traditional Chinese medicine considers that the insufficient intelligence or the hypophrenia is related to the factors such as deficiency of heart and spleen, fire excess from yin deficiency, imbalance of heart and kidney, phlegm-fluid and blood stasis, and the like, so the traditional Chinese medicine with the effects of tonifying deficiency and qi, tonifying spleen and kidney, eliminating phlegm and inducing resuscitation, promoting blood circulation and removing blood stasis, soothing the nerves and improving intelligence is compounded to play the effect of improving intelligence, such as ginseng, astragalus mongholicus, pseudo-ginseng, ganoderma lucidum, polygala tenuifolia, fructus alpiniae oxyphyllae, chinese yam and the like, but the target deficiency is often obvious on differentiation and treatment, the synergic mechanism of the traditional Chinese medicine in the prescription is not clear, the quality control and the cost control difficulty are increased, and the traditional Chinese medicine comprises the following raw materials: ginseng, prepared fleece-flower root, astragalus root, pseudo-ginseng, acanthopanax root, ganoderma lucidum, medlar, polygala tenuifolia, dried sweet potato, sesame oil and Chinese yam. Western medicine is used for treating patients suffering from brain injury and suffering from mental retardation, and has the advantages of lowering blood lipid and blood pressure, dilating blood vessels, improving circulation, promoting metabolism, inducing neuro-energy factors and the like, but has poor overall curative effect and obvious limitation on treatment means.

Therefore, the person skilled in the art is dedicated to develop a traditional Chinese medicine formula, a traditional Chinese medicine liquid and a pharmaceutical preparation with the effects of strengthening brain and improving intelligence.

Disclosure of Invention

In view of the above-mentioned drawbacks of the prior art, the present invention aims to provide a traditional Chinese medicine formulation, a traditional Chinese medicine liquid and a pharmaceutical preparation with an intelligence improving effect.

In order to achieve the aim, the invention provides a traditional Chinese medicine formula with an intelligence improving effect, which is prepared from the following raw materials in parts by weight: 175-185 parts of polygala tenuifolia, 95-105 parts of dried rehmannia root, 95-105 parts of semen cuscutae, 145-155 parts of shizandra berry, 145-155 parts of rhizoma acori graminei, 95-105 parts of dragon bone, 145-155 parts of ligusticum chuanxiong, 95-105 parts of cortex lycii radicis, 75-85 parts of fructus chebulae, 75-85 parts of fructus phyllanthi, 145-155 parts of rhizoma anemarrhenae, 115-125 parts of rhodiola rosea, 145-155 parts of American ginseng, 45-55 parts of liquorice, 95-105 parts of poria cocos, 145-155 parts of spina date seed, 145-155 parts of angelica sinensis, 85-95 parts of lucid ganoderma, 95-105 parts of cortex albiziae, 115-125 parts of lily, 145-155 parts of Chinese yam, 45-55 parts of platycladi seed, 45-55 parts of radix salviae miltiorrhizae, 115-125 parts of radix polygonati officinalis, 145-155 parts of oyster, 95-105 parts of longan pulp, 95-105 parts of tortoise plastron glue and 145-155 parts of fructus alpiniae oxyphyllae.

Preferably, the traditional Chinese medicine formula is prepared from the following raw materials in parts by weight: 175-180 parts of polygala tenuifolia, 95-100 parts of radix rehmanniae, 95-100 parts of semen cuscutae, 145-150 parts of shizandra berry, 145-150 parts of rhizoma acori graminei, 95-100 parts of dragon bone, 145-150 parts of ligusticum chuanxiong, 95-100 parts of cortex lycii radicis, 75-80 parts of fructus amomi, 75-80 parts of fructus terminaliae, 75-80 parts of fructus phyllanthi, 145-150 parts of rhizoma anemarrhenae, 115-120 parts of rhodiola rosea, 145-150 parts of American ginseng, 45-50 parts of liquorice, 95-100 parts of poria cocos, 145-150 parts of spina date seed, 145-150 parts of angelica sinensis, 85-90 parts of ganoderma lucidum, 95-100 parts of cortex albiziae, 115-120 parts of lily, 145-150 parts of Chinese yam, 45-50 parts of platycladi seed, 45-50 parts of radix salviae miltiorrhizae, 115-120 parts of radix polygonati officinalis, 145-150 parts of oyster, 95-100 parts of longan pulp, 95-100 parts of tortoise plastron glue and 145-150 parts of fructus alpiniae oxyphyllae.

Preferably, the traditional Chinese medicine formula is prepared from the following raw materials in parts by weight: 180-185 parts of polygala tenuifolia, 100-105 parts of dried rehmannia root, 100-105 parts of semen cuscutae, 150-155 parts of shizandra berry, 150-155 parts of rhizoma acori graminei, 100-105 parts of dragon bone, 150-155 parts of ligusticum wallichii, 100-105 parts of cortex lycii radicis, 80-85 parts of fructus chebulae, 80-85 parts of fructus phyllanthi, 150-155 parts of rhizoma anemarrhenae, 120-125 parts of rhodiola rosea, 150-155 parts of American ginseng, 50-55 parts of liquorice, 100-105 parts of poria cocos, 150-155 parts of spina date seed, 150-155 parts of angelica sinensis, 90-95 parts of lucid ganoderma, 100-105 parts of cortex albiziae, 120-125 parts of lily, 150-155 parts of Chinese yam, 50-55 parts of platycladi seed, 50-55 parts of radix salviae miltiorrhizae, 120-125 parts of pickled ginseng, 150-155 parts of rhizoma polygonati, 150-155 parts of oyster, 100-105 parts of longan pulp, 100-105 parts of tortoise plastron glue and 150-155 parts of fructus alpiniae.

Preferably, the traditional Chinese medicine formula is prepared from the following raw materials in parts by weight: 180 parts of polygala tenuifolia, 100 parts of dried rehmannia root, 100 parts of semen cuscutae, 150 parts of schisandra chinensis, 150 parts of rhizoma acori graminei, 100 parts of dragon bone, 150 parts of ligusticum wallichii, 100 parts of cortex lycii radicis, 80 parts of fructus amomi, 80 parts of fructus phyllanthi, 150 parts of rhizoma anemarrhenae, 120 parts of rhodiola rosea, 150 parts of American ginseng, 50 parts of liquorice, 100 parts of poria cocos, 150 parts of semen zizyphi spinosae, 150 parts of angelica sinensis, 90 parts of lucid ganoderma, 100 parts of cortex albiziae, 120 parts of lily, 150 parts of rhizoma dioscoreae, 50 parts of platycladi seed, 50 parts of glossy privet fruit, 150 parts of radix salviae miltiorrhizae, 120 parts of radix ginseng, 150 parts of rhizoma polygonati, 150 parts of oyster, 100 parts of arillus longan, 100 parts of tortoise shell glue and 150 parts of fructus alpiniae oxyphyllae.

The components are proportioned by weight, and can be increased or reduced according to proportion during production, for example, large-scale production can be carried out in kilograms or tons, small-scale production can be carried out in grams, and the weight can be increased or reduced, but the proportion of the weight proportion of crude drugs among the components is unchanged.

According to another aspect of the invention, the invention also provides a traditional Chinese medicine liquid with an intelligence improving effect, the traditional Chinese medicine liquid is obtained by the method of decocting the traditional Chinese medicine prescription with water, and the total water adding amount is calculated according to 3 to 5 times of the total weight of all the raw materials, and the traditional Chinese medicine liquid is decocted in two times.

Further, the preparation method of the traditional Chinese medicine liquid is as follows:

(1) Soaking: the following raw materials are used: radix Polygalae, radix rehmanniae, semen Cuscutae, fructus Schisandrae chinensis, rhizoma Acori Graminei, os Draconis, rhizoma Ligustici Chuanxiong, cortex Lycii, fructus Chebulae, fructus Phyllanthi, rhizoma anemarrhenae, radix Rhodiolae, radix Panacis Quinquefolii, glycyrrhrizae radix, poria, semen Ziziphi Spinosae, radix Angelicae sinensis, ganoderma, cortex Albizziae, bulbus Lilii, rhizoma Dioscoreae, semen Platycladi, fructus Ligustri Lucidi, saviae Miltiorrhizae radix, radix Ginseng, rhizoma Polygonati, concha Ostreae and arillus longan by soaking in 60% clear water for 2 hr;

(2) Decocting: boiling with strong fire, decocting with middle fire for 0.5 hr, adding fructus Alpinae Oxyphyllae, decocting for 0.5 hr, and pouring out the decoction; adding the residual water into the residue, decocting for the second time, boiling with strong fire, decocting with middle fire for 45 min, and pouring out the decoction; in the step, as the fructus alpiniae oxyphyllae contains the fragrant volatile oil, in order to ensure the efficacy of the fructus alpiniae oxyphyllae, the fructus alpiniae oxyphyllae is added at the moment instead of being soaked and decocted with the prior raw material medicines simultaneously;

(3) Standing and filtering: mixing the two decoctions, standing for 3 hr, and filtering with 200 mesh sieve; filtering the decoction, standing for 2 hr, and filtering again;

(4) Concentrating: and (3) boiling the filtered medicinal juice with strong fire, continuously concentrating with medium fire until the volume of the filtered medicinal juice is 40-42%, adding tortoise-plastron glue, and concentrating with slow fire until the volume of the filtered medicinal juice is 36-38%.

Still further, step (4) is followed by step (5) of adding a flavoring agent, wherein the flavoring agent is one or more of a sweetener, a flavoring agent, a mucilage, and an effervescent agent.

The sweetener is one or more of sucrose, simple syrup, orange peel syrup, citric syrup, cherry syrup, licorice syrup, cinnamon syrup, stevioside, glycerol, sorbitol, mannitol, saccharin sodium, aspartame and neotame. The sweetener can mask the astringent and bitter tastes of the medicine.

The flavoring agent is one or more of lemon, fennel, peppermint oil, apple essence, orange essence and banana essence. Fragrances are used in medicaments to improve the odor of the medicament.

The mucilage is one or a combination of sodium alginate, acacia, gelatin, methylcellulose and sodium carboxymethylcellulose. The mucilage has the property of being sticky and mild, and can interfere with the taste of taste buds to have the function of flavoring.

Furthermore, the flavoring agent is a combination of an effervescent agent and a sweetener, the effervescent agent is sodium bicarbonate powder, the sweetener is neotame, the sodium bicarbonate powder is added first, and when the foam in the medicinal juice is completely dispersed, the neotame is added. The reason that the neotame is added until the foam in the medicine juice is completely dispersed is that a large amount of organic acid substances exist in the medicine juice, which is a main reason for the sour taste of the medicine, after baking soda powder is added, a large amount of foam is generated in the acid-base neutralization process, the organic acid substances form organic acid sodium salt, the carbonic acid radical is replaced by carbonic acid, and the carbonic acid is decomposed into carbon dioxide gas to volatilize from the medicine juice, so that a large amount of foam is generated, and the neotame cannot react with the organic acid substances after being added, so that the sweet taste of the neotame is ensured to be kept in the medicine juice.

Further, the baking soda powder comprises, by weight, 2-10 parts of baking soda powder and 1-6 parts of neotame.

Still further, the method further comprises the step (6) of adding a preservative after the step (5), wherein the preservative is potassium sorbate, and the potassium sorbate is 1-10 parts by weight.

And (3) filling in the step (7) after the step (6), obtaining concentrated solution when the medicine juice is concentrated to 34-35% of the volume of the filtered medicine juice, stopping heating, placing the concentrated solution in a paste filling machine when the temperature of the medicine juice is reduced to 60 ℃, and filling in a sterilized oral liquid bottle.

Furthermore, the tortoise-plastron glue is crushed into powder by a crusher, so that the tortoise-plastron glue is ensured to be dissolved more completely and distributed more uniformly in the medicinal juice.

Further, the fructus chebulae, fructus chebulae and fructus alpiniae oxyphyllae are respectively smashed by a mortar, so that the effective components of the fructus chebulae, fructus chebulae and fructus alpiniae oxyphyllae can be fully dissolved in the medicinal juice.

According to another aspect of the invention, the invention also provides a pharmaceutical preparation with a beneficial effect, wherein the pharmaceutical preparation is prepared by adding the traditional Chinese medicine liquid into auxiliary materials commonly used in pharmacy. Pharmaceutically usual excipients that may be used in the present invention include, but are not limited to, pharmaceutically acceptable carriers, diluents, excipients, adjuvants, buffers, pH adjusting agents, preservatives, antioxidants, bacteriostats, stabilizers, suspending agents, solubilizing agents, surfactants (e.g., wetting agents), colorants, and isotonizing solutes. Suitable carriers, diluents, excipients, and the like can be found in standard pharmaceutical books. See, e.g., handbook of pharmaceutical additives (Handbook of Pharmaceutical Additives), second edition (editors m.ash and i.ash), 2001 (Synapse Information Resources, inc., endicott, new York, USA); remington's Pharmaceutical Science, 18 th edition, mack Publishing Company, easton, pa.,1990; and handbooks of pharmaceutical excipients (Handbook of Pharmaceutical Excipients), second edition, 1994.

Furthermore, the dosage form of the pharmaceutical preparation belongs to an oral pharmaceutical dosage form.

Further, the oral pharmaceutical dosage forms comprise sugar-coated tablets, film-coated tablets, enteric-coated tablets, capsules, oral liquid, syrup, buccal agent, granules, dripping pills, powder, ointment, suspension and powder.

The production processes for preparing the aforementioned pharmaceutical formulations are well known to those skilled in the art.

The beneficial effects of the invention are as follows: the invention is a special formulation carefully matched according to the formulation principle of 'monarch, minister, assistant and guide' of the traditional Chinese medicine ointment formulation theory, takes reading pills (polygala tenuifolia, grassleaved sweetflag rhizome, semen cuscutae, radix rehmanniae, cortex lycii radicis, schisandra chinensis, spina date seed, chinese angelica and ligusticum wallichii) as the monarch formulation, mainly treats amnesia and enhances memory; the Chinese medicinal composition is prepared from Sanle pulp (fructus Chebulae, fructus Phyllanthi, radix Rhodiolae, and radix Panacis Quinquefolii), and has effects of relieving fatigue, resisting anoxia, regulating immunity, improving memory function, increasing cerebral blood supply and oxygen supply, improving learning concentration, and improving phenomenon of study concentration failure; the ministerial decoction (tortoise shell glue, dragon bone, polygala root, grassleaved sweetflag rhizome and lucid ganoderma) has the effects of tonifying heart and kidney, promoting intelligence and soothing nerves, and is used for treating insomnia, amnesia and listlessness caused by imbalance of heart and kidney so as to enhance the effect of the monarch prescription in mainly treating amnesia; the jujube decoction (semen Ziziphi Spinosae, rhizoma Ligustici Chuanxiong, rhizoma anemarrhenae, poria, glycyrrhrizae radix, arillus longan and Concha Ostreae) is added to enhance the effect of the monarch prescription in treating amnesia; secondly, has the effects of nourishing blood, tranquilizing the mind, clearing heat and relieving restlessness, and is suitable for insomnia caused by insufficient liver blood and excessive pressure. Then the fructus alpiniae oxyphyllae is added for warming spleen, kidney and intelligence; the lily and the platycladi seed are added, so that the heart-fire clearing and nerve-soothing effects are realized, and the memory is helped; with the assistance of Chinese yam, rhizoma polygonati and glossy privet fruit, the kidney tonifying, yin nourishing and brain strengthening effects are achieved; with the assistance of cortex albiziae, the salvia miltiorrhiza has the effects of promoting blood circulation and dredging collaterals, and resolving depression and tranquillizing; the guiding drug is liquorice, harmonizes the drugs and rectifies the flavor; the whole formula is supplemented with clear and no stagnation. Through long-term clinical verification, the efficacy of the traditional Chinese medicine composition is clinically verified.

Detailed Description

The present invention will be described in further detail with reference to the following examples in order to make the objects, technical solutions and advantages of the present invention more apparent. It should be understood that the specific embodiments described herein are for purposes of illustration only and are not intended to limit the scope of the invention.

All the features disclosed in this specification, or the steps of all the methods or processes disclosed, except for the mutually exclusive features and/or steps, may be combined in any combination, unless specifically stated otherwise, with other equivalents or alternatives having a similar purpose, i.e., each feature may be replaced by one embodiment of a series of equivalents or similar features.

The traditional Chinese medicine has many discussions on nourishing brain and improving intelligence, and the mechanism of the traditional Chinese medicine can be slightly observed from the following aspects. The brain-nourishing and intelligence-improving Chinese medicine considers that the substance constituting the brain parenchyma is marrow, and human brain is formed by gathering marrow, for example, the brain is marrow sea, the inter-element and five viscera generating article, the marrow-bearing people belong to the brain. The "human memory is in the brain", so the brain-nourishing can enhance the memory. The Shen nong Ben Cao Jing (Shen nong's herbal) and Shen Hu Ma ren (Shen nong's herbal) have the functions of nourishing brain marrow and improving hearing and hearing, and the Shen Hua Zi Ben Cao (Shen nong's herbal) and the Lei Gong Zhi Jiu (Lei Gong Yao Jiu). Qing-Wang Qing Ji points out that "the inspiration is in the brain, and the clear of the healthy qi and blood, the long muscles and the essence and juice is converted into marrow, which goes upward from the spinal cord into the brain, called the day's brain marrow. The ears lead to the brain, and the heard sound is attributed to the brain; the two eyes are longer than the brain, and the seen thing goes to the brain; the nose is responsible for the brain, and the smell of smell is attributed to the brain. The children's brain is gradually born by the age of the year, and the tongue can say a Chinese character ' di '. In the sense of the gradual enrichment of brain marrow, infants start speaking, understanding and other mental activities, and the brain marrow works normally, so that the infants have preliminary mental activities in sense of sense perception such as vision, hearing and smell. The traditional Chinese medicine for invigorating brain can gain intelligence.

In addition, the spinal cord is particularly important in the process of forming and developing brain marrow, and is a channel connecting the brain and the whole body and continuously supplying nutrition to the brain, and the spinal cord is also the position of the governor vessel. The "difficult menstruation, twenty-eight difficult" says "the governor vessel starts from the back of the lower electrode and goes up to the wind-fu in the spine, and pertains to the brain". It has important effect on transporting essence to brain, so it goes up to brain and down to the bottom of tail, all of which are ascending and descending in essence (medical entry). Therefore, filling the spirit of the governor vessel to nourish the brain and improve the intelligence is also an important idea of the traditional Chinese medicine for nourishing the brain and improving the intelligence. As the former considers, the prescription of pilose antler, deer horn, tortoise plastron, marrow-supplementing pill and the like has the effects of directly filling marrow of governor vessel and nourishing brain and improving intelligence.

One of the characteristics of the theory of traditional Chinese medicine for nourishing heart and improving intelligence is the concept of unity. The understanding of brain function by traditional Chinese medicine also focuses on the general theory. The function of the brain is classified as five zang organs, the center of which is the most important. More emphasis is placed on mental activities of the human brain. For instance, in the theory of Ling Shu-Ben Shen, so that the person receiving the foreign matters is considered to be the heart.

Because of this knowledge, the traditional Chinese medicine claims to strengthen the thinking activities of people through the methods of tranquilizing mind, tonifying heart blood, tonifying heart qi, clearing heart heat and the like, so the mind-nourishing and intelligence-improving idea is provided. Because heart governs mind, there are many prescriptions for improving intelligence by tranquilizing mind, such as fructus Schisandrae chinensis and Zhenxindan. Heart governs blood vessels, and blood is the main material basis for mental activities. When heart blood is full, the mind is clear, the thinking is agile, and a good intelligence state can be shown; for example, heart blood deficiency often leads to pathological changes of heart spirit, resulting in insomnia, dreaminess, amnesia, etc., which impairs mental activities. At this time, heart blood is supplemented to promote intelligence, such as Dang Gui, di Huang, shou Wu and Tian Wang Buxin Dan. Blood does not run in the pulse to nourish the brain and the whole body, and depends on the promotion of heart qi, so that the heart qi is exuberant, and the blood pulse is full, so that the normal exertion of the function of "inducing resuscitation" can be ensured, and the mental thinking aspect is low and disturbed due to insufficient heart qi, heart blood deficiency or unsmooth blood circulation. At this time, it is indicated for heart qi to benefit intelligence, such as dangshen, huang Qi, ren Shen Yangrong Tang and Fu Yuan san.

Kidney-tonifying and intelligence-improving brains are located in the cranium and are formed by the marrow, how are the marrow produced? "Ling Shu & Jing Mai" indicates that "people start growing, first forming essence, then forming brain marrow". Brain marrow is considered to originate from the congenital essence of a person, i.e., the reproductive essence of a parent, while the kidney is responsible for reproduction, and the essence of reproduction is the essence of the kidney, so the formation and development of brain marrow has a very close relationship with the function of the kidney. Congenital essence is the basic substance forming the brain marrow, while acquired essence is a nutritional source that continuously fills the brain marrow. Acquired essence is the essence of the five zang-organs and six fu-organs, which is stored by the kidneys, as in the theory of inter-plain ancient book, "kidney governs water and is stored by the essence of the five zang-organs and six fu-organs". When kidney essence is sufficient, marrow is biochemically active, and when marrow is abundant, brain is vigorous, energy is abundant, and the brain is powerful, hearing and hearing are intelligent, and memory is not forgotten; deficiency of kidney essence, deficiency of brain, poor skill ability, amnesia, insomnia, and slow-down of the mind and aging. Therefore, the 'ling pi-hai Lun' says that 'marrow sea is excessive, light and powerful, from its excessive, marrow sea is insufficient, brain turning tinnitus, shin epidemic glaring, blindness, and relaxing and lying down'. From the above, it is clear that the traditional Chinese medicine emphasizes tonifying kidney to promote intelligence. The method is one of the important principles of traditional Chinese medicine intelligence development, and is used for tonifying kidney and replenishing essence, regenerating marrow and benefiting brain so as to achieve the purpose of enhancing intelligence. Ancient people required to tonify the marrow of the brain, it should first tonify the middle energizer essence.

Based on the theory, the scheme aims at the following three aspects of improving intelligence, strengthening brain, nourishing blood, tranquillizing and mainly treating heart and kidney deficiency, so the following raw material medicines are adopted:

radix polygalae: bitter and pungent properties and warm property. It enters heart, kidney and lung meridians. Polygalae radix is indicated for its property Xin Sangu to relieve heat and unblock the heart, lung and kidney meridians. Not only can invigorate heart yang and nourish heart qi, but also can induce resuscitation by dispelling phlegm, so as to treat heart-mind restlessness or phlegm obstructing heart orifices. The product contains saponin, and also contains polygalanone, alkaloid, polygalanol, tenuifolia alkali, fatty oil, resin, etc. Has effects of tranquilizing mind, improving intelligence, regulating heart and kidney, eliminating phlegm, and relieving swelling. Meanwhile, the Chinese medicinal composition also has the effects of enhancing learning and memory, tranquilizing and allaying excitement and resisting depression, and specific reference materials are [ 1 ] Korean, zhang Zhihua, cao Qiushi, lv Yinjuan. Pharmaceutical analysis of polygala tenuifolia [ J ]. Chinese medicinal report, 2018,24 (24): 127-129.【2】 Ind. Liu Yaqing, tian Cheng, zhang Xiaobo, wang Haibo. Evaluation of the quality of the active effect of polygala Multi-index ingredient, J. University of Liaoning, vol.24No.4Apr.,2022.

Radix rehmanniae: (Di Huang belongs to the genus Di Huang) generally refers to Di Huang, sheng Di Huang is sweet in flavor and cold in nature, and enters heart, liver and kidney meridians. Has effects of clearing heat, cooling blood, nourishing yin and promoting fluid production. This product was originally described in Shen nong Ben Cao Jing (Shen nong's herbal), and is listed as the above product: the main fracture failing to break the tendons and hurt the middle energizer. Dispel the blood stasis, fill the bone marrow and grow the muscles. It can be used as decoction for removing cold and heat accumulation and arthralgia. The chemical components in rehmannia root mainly comprise oligosaccharide, polysaccharide, iridoid glycoside, amino acid and the like, so that the rehmannia root also has the functions of promoting hematopoiesis, enhancing learning and memory capacity and improving hematopoiesis, and specific reference materials are [ 3 ] Liu Weixin, lu Yanwei, du Haitao and Wu Zuze, and the research progress of the pharmacological actions of the rehmannia root and active components thereof [ J ]. International pharmaceutical research journal 2009, 8 months, 36, 4.

Semen cuscutae: pungent and sweet in flavor, pacify and enter liver, kidney and spleen meridians. Semen Cuscutae can supplement Xin Run, has effects of relieving flatly and warming, nourishing yin and yang, and inducing astringency. Entering kidney meridian, tonifying yang and yin, securing essence and reducing urination, and treating impotence due to kidney deficiency, spermatorrhea, frequent urination, leukorrhagia and the like; enters liver and spleen meridians, nourishes liver and improves vision, tonifies spleen and relieves diarrhea, and treats diarrhea due to spleen deficiency and blindness. In addition, it can also promote the production of body fluid and quench thirst by tonifying liver and kidney, and can also promote the production of body fluid and quench thirst by regulating yin and yang. Mainly contains flavonoid, organic acids and other components, and also contains trace elements such as calcium, potassium, phosphorus and amino acids. Meanwhile, the Chinese medicinal composition also has the capability of improving cerebral ischemia, and specific reference materials are [ 4 ] Wang Huanjiang, zhao Jinjuan, liu Jinxian, wang Lei, lin Jianjiang and Lin Huibin, wherein the pharmacological action of the semen cuscutae and the development prospect of the semen cuscutae are [ J ]. Chinese medicinal journal.40, no.6 and 2012.

Chinese magnoliavine fruit: sour, sweet and warm nature, enter lung, heart and kidney meridians. Wu Wei Zi has the actions of astringing essence, moistening and tonifying, astringing and tonifying, and enters lung, kidney and heart meridians. It can astringe lung to relieve cough and dyspnea, nourish kidney, astringe essence to stop diarrhea, promote fluid production, calm heart and tranquilize mind, and strengthen exterior to arrest sweating. Five flavors are prepared, and only acid is unique; although warm, the skin is moist; astringing and tonifying are combined, and throttling and amplifying are performed. The herb is strong in action and is the key herb for tonifying deficiency, strengthening body and astringing. Meanwhile, the Chinese magnoliavine fruit health care food also has the effects of improving sleep and improving brain tissue functions, and specific reference materials are [ 5 ] Liu Jie, xu Jian and Guo Jiangtao, namely the Chinese magnoliavine fruit active ingredient and pharmacological effect research progress [ J ]. J.Chinese experimental prescription journal of science, vol.25, no.11Jun.,2019.【6】 Aristolochia Wang Shihua development of the pharmacological action of Schisandra chinensis [ J ]. Evaluation and analysis of Chinese Hospital medication Vol.18No.8,2018.

Rhizoma Acori Graminei: pungent, bitter and warm in property. It enters heart and stomach meridians. Grassleaf sweelflag rhizome Xin Sanxiang is used for channeling, bitter and dry, warm, and enter heart and stomach meridians. It is good at resolving phlegm-dampness, inducing resuscitation and relieving the symptoms of phlegm-dampness obstructing the heart orifice; it also has the actions of calming heart-mind, regulating stomach-qi, and treating palpitation, insomnia, amnesia, absentmindedness, damp-turbidity obstruction, vomiting and dysentery due to deficiency of heart-qi. Meanwhile, the Chinese medicinal composition also has the capability of improving spatial cognition and enhancing learning and memory, and specific reference materials are [ 7 ] Guo Junhe, chen Yunbo, wei Gang, nie Hui, zhou Ying, cheng Shuyi, wang Ji and Chen Dongfeng. The active components of grassleaved sweetflag rhizome have different proportion compatibility and influence on learning and memory functions of dementia mice [ J ]. Chinese medicinal novel medicaments and clinical pharmacology [ 2012March, vol.23 and No.2.

Keel: astringent, sweet and neutral in nature. It enters heart, liver and kidney meridians. Calm heart and tranquilize mind, calm liver and subdue yang, induce astringency and astringe. Can be used for treating palpitation, insomnia, amnesia, convulsion, epilepsy, giddiness, spontaneous perspiration, night sweat, spermatorrhea, enuresis, metrorrhagia, leukorrhagia, chronic diarrhea, chronic dysentery, ulcer, and damp sore. Keel is indicated for a wide variety of diseases, but not for the qi of the heart, it is astringent and can remove qi and consolidate the qi. The heart and abdomen cursory, the old charm of essence, the infantile convulsion and epilepsy caused by the dream and the disturbance of the mind, the dragon bone can calm the mind and calm the mind. Specific reference is [ 8 ] Li Yanran, chen Liyun. Herbal koku [ J ] university of Liaoning Chinese medical university journal of Vol.24, no.9, sep.,2022.

Ligusticum wallichii: pungent and warm in property. Enter liver, gallbladder and pericardium meridians. Rhizoma Ligustici Chuanxiong Xin Xianghang is used for dispelling heat and dredging, and is added into liver, gallbladder and pericardium channels. Ascending head and descending blood sea, moving blood and qi internally and dispelling wind-cold externally. It is indicated for pain due to blood stasis and qi stagnation with strong blood activating effect, and is most suitable for people with cold syndrome, and is known as qi-flowing in blood by the former. Treating various headaches, which are the best for wind-cold and blood stasis; it is also indicated for wind-heat, wind-damp and blood deficiency, so the former has the meaning of "headache is not separated from Chuan Xiong". Meanwhile, the compound preparation has the capabilities of enhancing cell viability, improving learning and memory capabilities and improving the survival rate of dopamine neurons, and specific reference materials are [ 9 ] o-secret, xu Shijun, and active ingredients of the rhizome of Sichuan lovage for improving the pharmacology of neurodegenerative diseases [ J ]. The world Chinese medicine August 2022, vol.15 and No.8.

Cortex Lycii: bitter taste; it is cold in nature. It enters liver, kidney, large intestine and stomach meridians. Can be used for treating dysentery with blood heat toxin, diarrhea due to intestinal wind, jaundice, leucorrhea with red and white discharge, infantile pneumonia, infantile malnutrition, acute tonsillitis, anal fistula, rectocele, skin pruritus, scabies, malignant sore, yin sore, damp itch, scrofula, and scald. It is used for treating trichomonas vaginitis. Modern pharmacological research shows that betaine in cortex lycii can inhibit the increase of RhoA, ROCK1 and ROCK2 protein expression in rat myocardial tissue, improve myocardial tissue necrosis, inflammatory cell infiltration and interstitial edema to protect rat acute myocardial ischemia injury induced by ISO.

Fructus Chebulae Immaturus: bitter and astringent, slightly cold. Enters the lung and stomach meridians. Clear heat and promote the production of body fluid, detoxify and astringe intestines. For pneumonia, dysentery, diphtheria due to yin deficiency. And (3) relieving aconite toxicity. The compound has a certain antioxidant activity, and specific reference materials are [ 10 ] Zhao Hongyan, liu Fang, xie Yonggong, dai Qing and Liu Songqing. Preliminary research on the antioxidant activity of the extract of fructus Canarii albi in vitro [ J ]. Third army university of medical science, 2017 and 39 (9).

Terminalia chebula fruit: neutral in nature, sweet and astringent in taste. It enters meridians and collaterals. Clearing heat and detoxicating, astringing and nourishing blood, and harmonizing various medicines. Belongs to the category of heat-clearing herbs and toxicity-removing herbs. The medicine has the functions of resisting depression, protecting heart and dilating blood vessels, and protecting rat brain from oxidative stress, and specific reference materials are [ 11 ] Cui Yu, dong Wanrong, liu Tiantian, zhu Weidong, zhougao, chen Yuxin, and the research progress of chemical components and pharmacological actions of the Terminalia chebula [ J ]. Chinese modern traditional Chinese medicine Jan.2023Vol.25No.1.

Fructus Phyllanthi: sweet, sour, astringent and cool in flavor, and enters lung and stomach meridians. Has effects of clearing heat and cooling blood, resolving food stagnation and invigorating stomach, promoting fluid production and relieving cough, and is commonly used for treating blood heat and blood stasis, dyspepsia, abdominal distention, cough, laryngalgia and dry mouth. The fructus Phyllanthi contains tannins, which contain various chemical substances such as glucogallin, gallic acid, etc. Fructus Phyllanthi, fructus crataegi and radix Canarii albi are arranged in parallel. The selenium content of the phyllanthus emblica fruit powder is 0.24 mg of selenium per 100 g of phyllanthus emblica fruit powder, which is positioned on the crown of the known human food. Selenium is the most important mineral nutrient for life extension. The extract has the effect of resisting arteriosclerosis, and specific reference materials are [ 12 ] Fan Yuan, liu Zhuhuan. The research progress of the arteriosclerosis resisting effect of the active component of phyllanthus emblica [ J ]. The Proc. Of Yunnan Chinese medicine university, vol.34No.2.4.2011.

Rhizoma anemarrhenae: bitter, sweet and cold in nature. It enters lung, stomach and kidney meridians. Rhizoma anemarrhenae, bitter in flavor, has a clear effect of expelling cold, and Gan Runzi is slippery, and enters the lung and stomach meridians as well as the kidney and large intestine meridians. But clear and descend, but not disperse, and nourish yin. Clearing lung-heat upwards to purge fire, clearing stomach-heat in the middle-jiao to relieve polydipsia, nourishing kidney-yin downwards to moisten dryness and smooth intestines, and removing deficiency-heat. Although it is inferior to Shi Gao in clearing heat and purging fire, it is good at nourishing yin and moistening dryness, and both dispelling pathogenic factors and strengthening body resistance. It is especially indicated for excessive heat, deficiency heat, high fever, dryness-heat and fluid impairment and yin deficiency with fever. The product contains saponin, rhizoma anemarrhenae polysaccharide, mangiferin, isoperidin, alkaloid, organic acid, etc. Has effects of clearing heat, purging pathogenic fire, nourishing yin, and moistening dryness. Timosaponin ZMS, an active ingredient of anemarrhena, is a novel anti-senile dementia drug, and can obviously improve the learning and memory capacity of rats with natural aging and the memory capacity of the old. Specific reference materials are [ 13 ] Chen Qin, hu Zhier and Xia Zongqin. Influence of timosaponin on learning and memory disorder and brain choline ethylphthalein transferase activity reduction caused by east-west alkali [ J ]. 24, 7 th, 2001, 7 th month of traditional Chinese medicine materials. 【14】 Feng Fei the development of pharmacological effect of rhizoma anemarrhenae [ J ] the clinical study of Chinese medicine in 2017, volume 9, phase 12.

Rhodiola rosea: sweet, bitter and flat property. Enter lung and heart meridians. Rhodiola rosea is sweet, bitter and purulent, flat and cool, and is also used for tonifying and dispersing, and entering lung and heart meridians. It is indicated for various syndromes due to qi deficiency, blood stasis and unsmooth blood vessels, especially for those with heat. Has the effects of tonifying qi, promoting blood circulation and relieving asthma, and has certain intelligence promoting effect, and can improve learning and memory ability, and specific reference materials are [ 15 ] Sun Xutao, liu Ying, jiang Deyou, chen Fei, jie Ying, sun Yang. 【16】 Huangfang active ingredients of radix Rhodiolae and pharmacological action [ J ]. J. Of Chinese medicine, oct.2008.Vol.20, no.5.

American ginseng: sweet and spicy in flavor, cool in nature and nontoxic. Enters the heart, lung and kidney. Benefit lung yin, clear deficiency fire, promote the production of body fluid and quench thirst. For chronic cough due to lung deficiency, blood loss, dry throat, thirst, dysphoria due to deficiency-heat. It has effects in relieving fatigue, enhancing anoxia resistance, and improving memory. Specific reference is [ 17 ] Wang Junmo. Recent progress in research on pharmacological actions of American ginseng [ J ]. Traditional Chinese medicine pharmacology and clinic 2001;17 (4).

Licorice root, radix Glycyrrhizae is sweet in nature and calm in nature, and enters heart, lung, spleen and stomach meridians. Licorice root, radix Glycyrrhizae Praeparata, sweet in taste, nourishes and moistens slowly, produces flat and cool, and is roasted to calm and warm, and enters spleen and lung meridians, stomach and heart meridians. Not only tonify qi and strengthen middle energizer, but also relieve spasm and pain, alleviate drug properties, and also eliminate phlegm and relieve cough and detoxify. The honey-fried qi-tonifying and urgent-relieving effects are strong; it can purge fire and detoxify. The product contains triterpene saponins and flavonoids. The licorice has the effects of invigorating spleen and replenishing qi, clearing heat and detoxicating, eliminating phlegm and relieving cough, relieving spasm and pain, and harmonizing various medicines, is mainly used for treating weakness of spleen and stomach, cough and excessive phlegm, poisoning and the like, and modern pharmacological researches prove that the licorice also has the effects of resisting tumor, resisting inflammation, participating in enzyme reaction, resisting bacteria, protecting liver, reducing blood sugar and estrogen, resisting rheumatism, resisting mental depression, inhibiting human immunodeficiency virus proliferation and the like. Specific reference materials are [ 18 ] Wang Bo, wang Li, liu Xiaofeng, cao Xinyuan, huang Wenhua and Xu Chao. The components and pharmacological actions of the Chinese medicinal licorice root and the research progress of modern clinical application [ J ] the Chinese medicine 2022, 2 nd month, 17 nd stage 2.

Poria cocos: sweet and bland in property and flat. It enters heart, lung, spleen and kidney meridians. Poria, poria cocos, radix et rhizoma Rhei, and Poria cocos, are sweet and light in nature, good in spleen and kidney meridians, and capable of excreting dampness and promoting diuresis to remove water retention, and invigorating spleen to promote water dampness transportation and transformation; it is indicated for heart meridian entered, heart-soothing and tranquillizing, and water-qi-flowing and heart-qi-flowing. It is good at treating edema due to spleen deficiency or excessive dampness, because it is indicated for water-damp and fluid retention, both cold and heat and spleen deficiency. The product mainly contains polysaccharide, triterpene component, sterol component, protein, fat, lecithin, adenine, etc. It has sedative hypnotic effect, and specific reference materials are [ 19 ] Pan Xin, dong Fangni, chen Yihan, zheng Dongmei. TOPSIS comprehensive analysis method for 6 active ingredients in Poria examined [ J ]. Shizhen national medicine, volume 32, 3 of 2021. 【20】 Azurin, liu Dongsheng, wang Lanxia, liu Jing, zhang Maina, gao Jia, zhu Xujiang Poria chemical composition, pharmacological action, and quality control study progress [ J ].2023, 2 nd month, 40 nd stage 2.

Semen Ziziphi Spinosae: sweet and sour in nature and flat in taste. It enters liver, gallbladder and heart meridians. The wild jujube seed is sweet, sour and calm, has flat property, enters heart, liver and gall meridians, nourishes heart, nourishes liver and benefit gall to calm the mind, and is an essential medicine for treating heart-mind restlessness, insomnia, dreaminess and palpitation due to deficiency of yin and blood; it can also arrest sweating, and is indicated for deficiency and excessive sweating. The product contains triterpene saponin, alkaloid, flavonoid, volatile oil, saccharide, protein, and organic acid. Has effects of nourishing heart, nourishing liver, tranquilizing mind, arresting sweating, and promoting salivation. The semen Ziziphi Spinosae is used as one of the common traditional Chinese medicines for treating insomnia, and has different pharmacological actions such as saponin, flavone, alkaloid, oil, etc. Specific reference materials are [ 21 ] Yuan Yangyang, sun Congyong, xu Ximing and Yu Jiang, and the research progress of pharmacological action mechanism of the active component of the semen zizyphi spinosae [ J ]. Chinese pharmacist, 2017, volume 20, 9.

Cortex Albiziae: sweet and flat property. It enters heart, liver and lung meridians. Albizia Pi Gan is mild, bitter in taste and can release, and mild in nature, enters heart and liver meridians. It is good at relieving liver depression and tranquillizing and stabilizing, and is commonly used for treating depression and insomnia; it also has effects in promoting blood circulation, dispelling blood stasis, and relieving carbuncle, swelling, and treating traumatic fracture, sore, carbuncle, and pulmonary abscess. The product mainly contains lignans, terpenes, saponins and tannins. Has effects of resolving depression, tranquilizing, promoting blood circulation, and relieving swelling. Meanwhile, the traditional Chinese medicine composition also has the functions of resisting anxiety and depression, and specific reference data are [ 22 ] Yang Lei and Li Dihua ] the chemical components and pharmacological activity of cortex albiziae and the development of toxicology research [ J ] the journal 2019 of the combination of Chinese traditional and Western medicine and surgery, the 25 th volume and the 6 th phase of the 12 th month.

Lily: sweet in flavor and cold in nature. It enters heart and lung meridians. Nourishing yin, moistening lung, clearing away heart-fire and tranquillizing. Can be used for treating cough due to yin deficiency and dryness, cough due to fatigue, hemoptysis, dysphoria, palpitation, insomnia, dreaminess, and absentmindedness. Meanwhile, the product also has the effects of tranquilizing, promoting sleep and improving memory, and the specific reference data is [ 23 ] Leimengmen, pharmacology action research progress [ J ] of Paeonia ostii, volume 34, 3 of professional and health 2018, 2 months.

Semen Platycladi: sweet and flat property. It enters heart, kidney and large intestine meridians. Bai Zi ren is sweet and can tonify, smooth and cool, and moisten, and is a food for smooth and moisten dryness. Entering heart and kidney meridians, it can tonify yin and blood to tranquilize the mind and nourish heart, and treat dysphoria and insomnia due to yin and blood deficiency; it enters large intestine meridian, can moisten intestine and dry stool to relieve constipation, and is indicated for constipation due to yin-blood deficiency. In addition, it can tonify yin and blood to stop sweating and treat night sweat due to yin deficiency. The product mainly contains cypress wood alcohol, sitosterol and diterpenoid components; also contains fatty oil, and contains small amount of volatile oil, saponin, vitamin A, protein, etc. Has effects of nourishing heart, tranquilizing mind, loosening bowel to relieve constipation, and relieving sweat. Meanwhile, the compound preparation has the effect of improving the behaviors of rats with Alzheimer's Disease (AD) models and prolonging the sleeping time of the mice, and specific reference data are [ 24 ] Zhujing, xu Yifan. Research progress of chemical components and pharmacological activity of platycladi [ J ]. Chemical research, 2019, 7 months, 30 th and 4 th phases. 【25】 Ma Xinyue, li Ruihai, gu Tianzhu pharmaceutical activity of semen Platycladi total terpenoid component and extraction process research [ J ]. Practical medicine and clinical 2017, volume 20, stage 1.

Fructus ligustri lucidi: sweet, bitter and cool in property. It enters liver and kidney meridians. The glossy privet fruit is sweet and cool and clear, bitter and free from greasy, enters liver and kidney meridians, and is a cool and tonic herb. It is good at nourishing yin of liver and kidney, and can clear deficiency heat and improve eyesight. Fructus Ligustri Lucidi contains triterpene component, iridoid glycoside component, flavonoid component, fatty acid component, volatile oil, and polysaccharide. Meanwhile, the Chinese herbal medicine fructus ligustri lucidi has the functions of resisting aging, resisting oxidation and enhancing immunoregulation, and specific reference materials are [ 26 ] Bi Ying, zhao Yuan, li Zhixiao, zhang Heming, sun Yunlong and Shang Kun.

Root of red-rooted salvia: bitter can dispel heat, clear slightly cold, enter heart and liver meridians. Not only activating blood and removing stasis to relieve pain, but also refreshing and cooling blood to relieve restlessness and remove carbuncle, and is mainly indicated for blood stasis, blood heat and heat disturbing heart-mind syndromes, and also for sore and abscess swelling and pain due to heat toxin. The product contains quinone components, protocatechuic aldehyde, protocatechuic acid, lactic acid, vitamin E, etc., and has effects of promoting blood circulation, removing blood stasis, dredging channels, relieving pain, clearing heart fire, relieving restlessness, cooling blood, and removing carbuncle. Meanwhile, the composition also has the effects of improving hemodynamic effects, resisting thrombus and resisting lipid peroxidation, and the specific reference data is [ 27 ] high wave, pharmacological analysis of the red sage root and clinical application research [ J ]. Chinese health standard management CHSM 09.【28】 Song Liqun the progress of the research on the pharmacological actions of Salvia Miltiorrhiza [ J ]. Community journal of medicine, 2012, 12 th month, 10 th edition, 24 th edition.

Radix Ginseng alba (radix adenophorae): sweet and slightly bitter in flavor and slightly cold in nature. Enter lung and stomach meridians. Nourishing yin, clearing heat, moistening lung, resolving phlegm, benefiting stomach and promoting fluid production. Can be used for treating chronic cough due to yin deficiency, tuberculosis, cough with phlegm blood, dry cough with little phlegm, asthenic fever, pharyngitis, and thirst due to fluid consumption. Meanwhile, the Chinese medicinal composition also has the effect of improving memory, and specific reference materials are [ 29 ] Liang Li, wang Ting, qiao Hua, chang Wei and Li Dan, the research on pharmacological effects of the adenophora polysaccharide is [ J ]. North pharmaceutical journal of northwest, volume 23, and 5 of 2008, 10 months.

Rhizoma polygonati: sweet in property, and good in property, enters spleen, lung and kidney meridians. Polygonatum rhizome, rhizoma Polygonati is sweet and tonic in nature, is flat but not biased, has mild action, enters spleen, lung and kidney meridians, and is a herb of balancing and tonifying qi and yin. It is effective in nourishing yin, moistening lung, invigorating kidney, replenishing vital essence, invigorating spleen, and replenishing qi, and can be used for treating deficiency of both lung and kidney, and deficiency of both qi and yin. The product contains polysaccharide, saponins, flavonoids, etc., and has effects of invigorating qi, nourishing yin, invigorating spleen, moistening lung, and invigorating kidney. The polygonatum cyrtonema has pharmacological effects of anti-tumor, anti-oxidation, anti-aging, anti-fatigue, blood sugar and blood lipid reducing, atherosclerosis resisting, sterilization and anti-inflammatory activities and the like, and specific reference data are [ 30 ] high-concentration, active ingredients of polygonatum cyrtonema and pharmacological effect research progress [ J ] Fujian agriculture technology, 2021, 52 (8).

Oyster: salty-wet and cool. Enter the liver and kidney meridians. Astringing yin, suppressing yang, suppressing sweating, astringing essence, eliminating phlegm, and softening hard masses. It is indicated for convulsive epilepsy, dizziness, spontaneous perspiration, night sweat, spermatorrhea, stranguria with turbid urine, metrorrhagia, leukorrhagia, scrofula and goiter. Can be used for treating palpitation, insomnia, dizziness, tinnitus, scrofula, phlegm nodule, spontaneous perspiration, night sweat, spermatorrhea, leukorrhagia, gastralgia, and pantothenic acid. Calcined oyster has the effect of astringing and inducing astringency. The Chinese medicinal composition also has the effects of improving the immunity of organisms, enhancing the memory, supplementing energy and the like, and specific reference data are [ 31 ] Feng Li, zhao Wenjing, but only the pharmacological action of oyster, the research progress of clinical application [ J ]. Chinese medicinal information, volume 28 of 2011, phase 1.

Longan pulp: sweet and flat. Enter heart and spleen meridians. Tonifying heart and spleen; tonifying qi and blood; an Xinshen. Deficiency of both the heart and spleen; palpitations caused by deficiency of qi and blood; palpitations; insomnia; forgetfulness; blood deficiency sallow; the menstruation is not regulated; metrorrhagia and metrostaxis. The longan pulp is nutritious, and has main chemical components including saccharide, lipid, saponin, polypeptide, polyphenol, volatile component, amino acid and trace elements. Meanwhile, the compound also has the effects of anti-stress, anti-anxiety and anti-oxidation, and specific reference materials are [ 32 ] Cheng Kangmei and Wang Hongjie, namely, the research progress of chemical components and pharmacological actions of longan pulp [ J ]. Chinese experimental prescription journal, namely, the 5 th stage of the 16 th volume of 2010 and 5 months.

Fructus alpiniae oxyphyllae: pungent and warm in nature; enter spleen and kidney meridians. It is pungent, warm, fragrant and dry, and enters spleen and kidney meridians. Not only warms the kidney, fixes essence and reduces urine, but also treats seminal emission and spermatorrhea due to kidney deficiency; but also warm spleen to check diarrhea, promote appetite and take in saliva, treat diarrhea, abdominal pain or salivary saliva due to cold in spleen. The product mainly contains volatile oil: eucalyptol, gingerol, and the like; also contains heptane derivatives, trace elements, vitamins, amino acids, fatty acids, etc. The active ingredients of fructus Alpinae Oxyphyllae have definite neuroprotection, and specific reference materials are [ 33 ] Wang Shuang, wang Tingting, zhang Hong, shi Huaisheng, zhao Saijun, po Jin Hua, tian Junna [ J ]. Based on network pharmacology, the action mechanism of fructus Alpinae on Alzheimer disease is discussed.

Chinese yam: the mountain drug property Ping Weigan is warm and different, slightly fragrant and not dry, enters spleen, lung and kidney meridians, is a good drug for tonifying spleen and stomach, promoting the production of body fluid and benefiting lung, and is also a traditional health food. Rhizoma Dioscoreae contains abundant microelements. The Chinese yam extract has the functions of resisting oxidation and improving senile dementia, and specific reference materials are [ 34 ] Liu Gaizhi, zhu Yilin, xu Dujuan, liu Mengya and Cai Bangrong. The network pharmacological action mechanism of the Chinese yam active ingredient for resisting senile dementia is discussed [ J ]. New Chinese medicine and clinical pharmacology are [ 2021, 3 rd month, 32 rd stage. 【35】 Yang Yan, sun Yuling, sun Jianmei, tang Zongxiang research progress of pharmacological action of active ingredient of rhizoma Dioscoreae [ J ]. Chinese wild plant resource, 2022, 12, 41, 12.

Ganoderma lucidum: ping Wei it is sweet in property, and can be used for treating heart, liver, lung and kidney meridians, and cough and asthma due to its action of tonifying qi and tranquillizing, and for treating symptoms such as restlessness, insomnia, palpitation, cough and asthma due to lung deficiency, consumptive disease, short breath, and anorexia. Ganoderma contains various chemical components, wherein the active ingredients are mainly polysaccharides, triterpenes, nucleosides, and sterols. The ganoderma lucidum has wide regulation effect on cardiovascular system, and adenosine contained in the ganoderma lucidum can effectively reduce blood viscosity, inhibit platelet aggregation in vivo, improve the content of hemoglobin, improve the oxygen supply capacity of blood and accelerate blood circulation. Ganoderma has two-way regulating effect on blood pressure; can effectively relax coronary artery, increase blood flow, improve body microcirculation, increase myocardial oxygen supply, and reduce cholesterol and neutral fat content in blood. Specific reference materials are [ 36 ] Xie Yiqiong, wang Qirui, sun Saiya, laimeng ru, cheng Rubin, xiaohua. Pharmacological action of ganoderma lucidum and clinical application research progress [ J ]. Clinical medicine research and practice. 2020,5 (10). 【37】 Song Baolan the research progress of the pharmacological action of Ganoderma lucidum [ J ]. Chinese folk medicine 2014,23 (10).

Chinese angelica root: dang Gui is warm, pungent and sweet in nature and has the effects of moistening dryness and lubricating intestines, treating constipation and irregular menstruation, etc., so that it is often called "Yaowang" by Chinese medicine. Meanwhile, the Chinese medicinal composition also has the effects of increasing blood flow, enriching blood, protecting nervous system, and has good effects of anticonvulsant, easing pain, repairing nerves and the like, and specific reference data are [ 37 ] Huang Gonghong, margaritima and Liu Xianfu. Chemical composition analysis and pharmacological action research [ J ] of Chinese angelica, the 19 th 58 th period of the latest medical information abstract in the world in 2019.

Tortoise-shell glue: cool and salty in taste, enters liver, kidney and heart meridians, mainly has the effects of nourishing yin and blood, strengthening tendons and bones and the like, is suitable for symptoms such as yin deficiency hectic fever, bone steaming night sweat, soreness and weakness of waist and knees, blood deficiency and sallow complexion and the like, and is especially suitable for female people needing to strengthen tendons and bones, nourish yin and blood and climacteric. Meanwhile, the traditional Chinese medicine has the effects of enhancing immunity, increasing coronary flow and improving hypoxia tolerance, and specific reference materials are [ 38 ] Zheng Benduan, lv Guo, luo Ziwen, and the research on the pharmacological action of tortoise shell glue is [ J ]. Shizhen national medicine, 2001, volume 12, and 5.

The traditional Chinese medicine formula with the intelligence-improving effect is based on the formula idea of the traditional Chinese medicine ointment formula: the pill is prepared from cortex et radix Polygalae, rhizoma Acori Graminei, semen Cuscutae, radix rehmanniae, cortex Lycii, fructus Schisandrae chinensis, semen Ziziphi Spinosae, radix Angelicae sinensis, and rhizoma Ligustici Chuanxiong by taking as principal prescription, and can be used for treating amnesia and improving memory; the Chinese medicinal composition is prepared from Sanle pulp (fructus Chebulae, fructus Phyllanthi, radix Rhodiolae, and radix Panacis Quinquefolii), and has effects of relieving fatigue, resisting anoxia, regulating immunity, improving memory function, increasing cerebral blood supply and oxygen supply, improving learning concentration, and improving phenomenon of study concentration failure; the ministerial decoction (tortoise shell glue, dragon bone, polygala root, grassleaved sweetflag rhizome and lucid ganoderma) has the effects of tonifying heart and kidney, promoting intelligence and soothing nerves, and is used for treating insomnia, amnesia and listlessness caused by imbalance of heart and kidney so as to enhance the effect of the monarch prescription in mainly treating amnesia; the jujube decoction (semen Ziziphi Spinosae, rhizoma Ligustici Chuanxiong, rhizoma anemarrhenae, poria, glycyrrhrizae radix, arillus longan and Concha Ostreae) is added to enhance the effect of the monarch prescription in treating amnesia; secondly, has the effects of nourishing blood, tranquilizing the mind, clearing heat and relieving restlessness, and is suitable for insomnia caused by insufficient liver blood and excessive pressure. Then the fructus alpiniae oxyphyllae is added for warming spleen, kidney and intelligence; the lily and the platycladi seed are added, so that the heart-fire clearing and nerve-soothing effects are realized, and the memory is helped; with the assistance of Chinese yam, rhizoma polygonati and glossy privet fruit, the kidney tonifying, yin nourishing and brain strengthening effects are achieved; with the assistance of cortex albiziae, the salvia miltiorrhiza has the effects of promoting blood circulation, dredging collaterals, resolving depression and soothing nerves, so that the whole formula is supplemented with the functions of clearing heat and tonifying without stagnation.

Comprehensive view of the whole formula: has effects of improving intelligence, nourishing brain, nourishing blood, tranquilizing mind, and can be used for treating hypomnesis, amnesia, fatigue, inattention, hypofunction, insomnia, etc. due to heart and kidney deficiency. The recipe gives consideration to the five zang organs, has the functions of invigorating the middle warmer, tonifying without stagnation, and taking into account the warm, cold and cool nature of the whole herb.

EXAMPLE 1 preparation of liquid medicine

1. The following traditional Chinese medicine raw materials and chemical raw materials are accurately weighed: 175 parts of polygala tenuifolia, 95 parts of dried rehmannia root, 95 parts of semen cuscutae, 145 parts of schisandra chinensis, 145 parts of rhizoma acori graminei, 95 parts of dragon bone, 145 parts of ligusticum chuanxiong, 95 parts of cortex lycii radicis, 75 parts of fructus amomi, 75 parts of fructus phyllanthi, 145 parts of rhizoma anemarrhenae, 115 parts of rhodiola rosea, 145 parts of American ginseng, 45 parts of liquorice, 95 parts of poria cocos, 145 parts of semen zizyphi spinosae, 145 parts of angelica sinensis, 85 parts of lucid ganoderma, 95 parts of cortex albiziae, 115 parts of lily, 145 parts of Chinese yam, 45 parts of platycladi seed, 45 parts of glossy privet fruit, 145 parts of radix salviae miltiorrhizae, 115 parts of radix ginseng, 145 parts of rhizoma polygonati, 145 parts of oyster, 95 parts of arillus longan, 95 parts of tortoise shell glue and 145 parts of fructus alpiniae oxyphyllae, 2 parts of baking soda powder, 1 part of neose and 1 part of potassium sorbate.

Wherein the neotame is a compound sweetener with molecular formula of C ₂₀ H ₃₀ N ₂ O ₅ CAS number 165450-17-9, produced by Guangdong source food ingredients Co., ltd., purity 99%, model number food grade.

Potassium sorbate, molecular formula C ₆ H ₇ KO ₂ CAS number 590-00-1, shanghai Shen Xia Biochemical Co., ltd., purity 99%,25kg (dry weight) carton package.

Baking soda with molecular formula of NaHCO, CAS number of 144-55-8, manufactured by Suzhou products cisco chemical Co., ltd., purity of 99%, and packaging of 25 kg.

2. The preparation method comprises the following steps:

(1) Pulverizing colla Plastri Testudinis into powder with pulverizer, and respectively pulverizing fructus Chebulae, fructus Terminaliae Billericae and fructus Alpinae Oxyphyllae with pot;

(2) Calculating the total water adding amount according to 3 times of the total weight of all the raw materials, and decocting twice;

(3) Soaking: the following raw materials are used: radix Polygalae, radix rehmanniae, semen Cuscutae, fructus Schisandrae chinensis, rhizoma Acori Graminei, os Draconis, rhizoma Ligustici Chuanxiong, cortex Lycii, fructus Chebulae, fructus Phyllanthi, rhizoma anemarrhenae, radix Rhodiolae, radix Panacis Quinquefolii, glycyrrhrizae radix, poria, semen Ziziphi Spinosae, radix Angelicae sinensis, ganoderma, cortex Albizziae, bulbus Lilii, rhizoma Dioscoreae, semen Platycladi, fructus Ligustri Lucidi, saviae Miltiorrhizae radix, radix Ginseng, rhizoma Polygonati, concha Ostreae and arillus longan by soaking in 60% clear water for 2 hr;

(4) Decocting: boiling with strong fire, decocting with middle fire for 0.5 hr, adding fructus Alpinae Oxyphyllae, decocting for 0.5 hr, and pouring out the decoction; adding the residual water into the residue, decocting for the second time, boiling with strong fire, decocting with middle fire for 45 min, and pouring out the decoction;

(5) Standing and filtering: mixing the two decoctions, standing for 3 hr, and filtering with 200 mesh sieve; filtering the decoction, standing for 2 hr, and filtering again;

(6) Concentrating: and (3) boiling the filtered medicinal juice with strong fire, continuously concentrating with medium fire until the volume of the filtered medicinal juice is 40-42%, adding tortoise-plastron glue, and concentrating with slow fire until the volume of the filtered medicinal juice is 36-38%.

(7) Adding flavoring agent and antiseptic: adding sodium bicarbonate powder, adding neotame and potassium sorbate when the foam in the medicinal liquid is completely dispersed, and continuing concentrating.

(8) And (3) filling: concentrating the medicinal liquid to 34-35% of the filtered medicinal liquid volume, stopping heating, and placing the concentrated liquid into paste filling machine when the temperature of the medicinal liquid is reduced to 60deg.C, and filling into sterilized oral liquid bottle.

EXAMPLE 2 preparation of Chinese medicinal liquid

1. The following traditional Chinese medicine raw materials and chemical raw materials are accurately weighed: 180 parts of polygala tenuifolia, 100 parts of dried rehmannia root, 100 parts of semen cuscutae, 150 parts of schisandra chinensis, 150 parts of rhizoma acori graminei, 100 parts of dragon bone, 150 parts of ligusticum chuanxiong, 100 parts of cortex lycii radicis, 80 parts of fructus amomi, 80 parts of fructus phyllanthi, 150 parts of rhizoma anemarrhenae, 120 parts of rhodiola rosea, 150 parts of American ginseng, 50 parts of liquorice, 100 parts of poria cocos, 150 parts of spina date seed, 150 parts of angelica sinensis, 90 parts of lucid ganoderma, 100 parts of cortex albiziae, 120 parts of lily, 150 parts of Chinese yam, 50 parts of platycladi seed, 50 parts of glossy privet fruit, 150 parts of radix salviae miltiorrhizae, 120 parts of radix ginseng, 150 parts of rhizoma polygonati, 150 parts of oyster, 100 parts of arillus longan, 100 parts of tortoise plastron glue and 150 parts of fructus alpiniae oxyphyllae, 5 parts of baking soda powder, 3 parts of neose and 5 parts of potassium sorbate.

2. The preparation method comprises the following steps:

(2) Calculating the total water adding amount according to 4 times of the total weight of all the raw materials, and decocting twice;

EXAMPLE 3 preparation of Chinese medicinal liquid

1. The following traditional Chinese medicine raw materials and chemical raw materials are accurately weighed: 185 parts of polygala tenuifolia, 105 parts of dried rehmannia root, 105 parts of semen cuscutae, 155 parts of shizandra berry, 155 parts of grassleaf sweetflag rhizome, 105 parts of dragon bone, 155 parts of szechuan lovage rhizome, 105 parts of cortex lycii radicis, 85 parts of fructus amomi, 85 parts of emblic leafflower fruit, 155 parts of rhizoma anemarrhenae, 125 parts of rhodiola rosea, 155 parts of American ginseng, 55 parts of liquorice, 105 parts of poria cocos, 155 parts of spina date seed, 155 parts of Chinese angelica, 95 parts of lucid ganoderma, 105 parts of cortex albiziae, 125 parts of lily, 155 parts of Chinese yam, 55 parts of platycladi seed, 55 parts of glossy privet fruit, 155 parts of red sage root, 125 parts of ginseng, 155 parts of rhizoma polygonati, 155 parts of oyster, 105 parts of longan pulp, 105 parts of tortoise plastron glue and 155 parts of fructus alpiniae oxyphyllae, 10 parts of baking soda powder, 6 parts of neose and 10 parts of potassium sorbate.

2. The preparation method comprises the following steps:

(2) Calculating the total water adding amount according to 5 times of the total weight of all the raw materials, and decocting twice;

(7) Adding flavoring agent and antiseptic: adding sodium bicarbonate powder, and adding neotame and potassium sorbate when the foam in the medicinal liquid is completely dispersed.

The traditional Chinese medicine liquid with the intelligence improving effect is subjected to pharmacological toxicity experiments, influence experiments on learning and memory of mice, anti-fatigue effect experiments on mice, human body test feeding experiments for improving sleep and clinical tests for children, and the test conditions and results are as follows:

1. the traditional Chinese medicine liquid in the example 2 is taken as an experimental object, and the pharmacological toxicity experiment is verified to comprise an acute toxicity experiment and a long-term toxicity experiment through a pharmacological toxicity experiment. Acute toxicity experiments were as follows:

1. experimental method

The depilatory agent was uniformly applied to both sides of the guinea pig back spine to a depilating range of about 20 square cm. Washing depilatory, putting into a cage, observing for 24 hours, respectively coating 4 g, 8 g and 12g of the Chinese medicinal liquid of the invention on each group of guinea pigs, respectively containing 90mg, 182mg and 366mg of crude drugs, and coating 0.8ml of solvent on the other group of guinea pigs twice daily for one week, and after the experiment is finished, killing the guinea pigs, and performing pathological examination on heart, liver, kidney and depilated skin.

2. Results

The three groups of guinea pigs have no edema, congestion, erythema, bleeding spots or ulcers on the local skin in the trunk dehairing area. The hair color, ingestion, limb movement and other control groups of the administration group guinea pigs have no obvious difference, and the administration group heart, liver, kidney and pelt are also not obviously different from the control words in pathological tissue examination.

The results indicate that the invention has no local stimulation and no systemic toxicity. The preparation of the invention is safe to use.

The long-term toxicity experiments were as follows:

1. experimental method

Guinea pigs were randomly allocated to 4 groups of 15, and the depilatory agent was uniformly applied to both sides of the back spine of the guinea pig to a depilation range of about 20 square cm. The depilatory is washed, each group of guinea pigs is respectively coated with 0.2, 0.4 and 0.8ml of the traditional Chinese medicine liquid of the invention after 24 hours, the crude drugs respectively contain 90, 182 and 366mg, the other group of guinea pigs is coated with 0.8ml of the solvent twice daily for 30 days continuously, the general condition of the guinea pigs is observed, and the animals are sacrificed for hematology, blood biochemistry and pathology examination after the experiment is finished.

2. Results

The three groups of drug-applied guinea pigs have no edema, congestion, erythema, bleeding spots and ulcers on the local skin in the trunk dehaired areas. The medicine group and the control group have no obvious difference in hair color, ingestion, limb movement and other control groups, and the blood biochemical examination is carried out, and the medicine group and the control group are in normal range. The pathological histology examination shows that no obvious lesions are found on the heart, liver, kidney and local skin of each group. The long-term administration of the invention has no obvious toxic effect on local skin and important viscera of the whole body. The test results show that: the invention is safe in experiment.

Cumulative toxicity experiment:

the oral liquid of the invention is continuously applied to mice according to the crude drugs of 7.83, 19.02 and 42.98 g/kg for 15 weeks (1.0 ml/100g of body weight, 2 times a day) and 3 weeks after stopping the application, and the results show that: the invention has no obvious influence on indexes such as hair, behaviors, urination and defecation, body weight, organ weight, hemogram, liver and kidney functions, blood sugar, blood fat and the like of the rat, and the viscera naked eyes do not find abnormal changes and histological examination results, so that after 15 weeks of administration and 3 weeks of withdrawal, all organs of the rat are not obviously changed. The invention has little toxicity after long-term administration to rats, no abnormal reaction after stopping administration and safe application.

2. Test of the influence of the Chinese medicinal liquid on the learning and memory of mice

100 SPF-class BABL/c mice, which are qualified, are pre-selected by a diving method, are 2 months old, have a weight of 20-24 g, are half-divided into 4 groups, and 25 mice in each group are respectively an example 1 group, an example 2 group, an example 3 group and a blank control group. Wherein, the blank group is filled with distilled water, the Chinese medicinal liquid in examples 1, 2 and 3 are respectively filled with the Chinese medicinal liquid in examples 1, 2 and 3, and the dosage of each filling is 600mg/kg, and the filling is carried out 2 times a day. Each group of rats was continuously intragastrically for 21 days. Each mouse was trained 1 time on day 20 with the diving tower method, and after 24 hours the test was started and the diving latency (time to jump down from the diving tower) and number of errors within 5min were recorded for each group of mice. The results are shown in Table 1 below.

TABLE 1 influence of the Chinese medicinal liquid on learning and memory acquisition ability of Normal mice

Group of	Jumping latency period(s)	Number of errors in 5min
			Example 1 group	16.65±3.64	2.67±1.06
Example 2 group	18.97±3.01	2.36±1.03
			Example 3 group	18.03±2.33	2.86±1.05
Blank control group	10.87±2.88	5.42±1.26

The results show that the traditional Chinese medicine liquid prepared in the examples 1-3 can obviously enhance the learning and memory capacity of mice, and especially has the best effect in the example 2.

3. Test of anti-fatigue effect of Chinese medicinal liquid on mice

The swimming method is used for preselecting qualified healthy SPF-grade BABL/c mice, 75 mice are aged for 2 months, the mass is 20-24 g, the animals can drink water and eat and drink freely, and after the animals observe and adapt to the mice for 5 days, the experiment is carried out. Animals were randomly divided into five groups, namely, a normal control group, a swimming control group, an example 1 group, an example 2 group and an example 3 group, wherein 15 animals in each group are respectively subjected to gastric lavage in the examples 1, 2 and 3 groups, the dosage of each gastric lavage is 1200mg/kg, the gastric lavage is carried out 1 time a day for 2 weeks, and the normal control group and the swimming control group are subjected to gastric lavage with equal amounts of distilled water.

Mouse swimming experiment and observation index

Before formal swimming, the animals are trained for 5 times in swimming. (1) exhaustive swimming: examples 1, 2, 3 and swimming control groups were all placed in the swimming device after 1 gastric lavage for 30 minutes, and at the same time, 3% of the weight was put into the swimming device to swim, the water temperature was 30 ℃, and the swimming was continued until the swimming was completed (immersed in water for 30 seconds). Record the time of the exhaustive swimming. (2) 90min swimming: animals of example 1, example 2, example 3 and swimming control group were placed in the swimming device 30 minutes after the last gastric lavage, with water temperature of 30 ℃ and swimming time of 90min. Normal control group did not swim. After swimming, the eyeballs of the mice are immediately picked up for blood sampling, serum is centrifugally taken, and the blood sugar content, the lactic acid content, the blood urea nitrogen content and the liver glycogen content are measured.

Table 2 comparison of the exhaustive swimming time (min) for each group of mice

Group of	Quantity (n)	Dragon swimming time (min)
			Swimming control group	15	0.86±0.15
Example 1 group	15	1.47±0.12
			Example 2 group	15	1.53±0.13
Example 3 group	15	1.52±0.15

As can be seen from table 2, the examples 1, 2 and 3 respectively have an extended time of exhaustive swimming and a significant difference compared to the swimming control group.

TABLE 3 comparison of blood sugar, blood lactic acid, blood Urea Nitrogen and liver glycogen detection results after completion of swimming in mice of each group

As shown in Table 3, compared with the normal control group, the blood sugar and liver sugar content of the swimming control group are reduced, the blood lactic acid and urea nitrogen level are increased, and the difference is significant. Compared with the swimming control group, the blood sugar and liver sugar raw water in the groups of the examples 1, 2 and 3 are averagely improved, the blood lactic acid and urea nitrogen levels are reduced, wherein the blood sugar and urea nitrogen changes have a certain metering effect trend, the blood sugar content in the groups of the examples 1, 2 and 3 is obviously higher than that in the swimming control group, the blood urea nitrogen level in the groups of the examples 1, 2 and 3 is obviously lower than that in the swimming control group, the liver sugar raw water in the groups of the examples 1, 2 and 3 is averagely higher than that in the swimming control group, and the difference is obvious.

The experimental result shows that after the traditional Chinese medicine liquid is used, the animal's life-time is obviously prolonged, which indicates that the traditional Chinese medicine composition has obvious refreshing and anti-fatigue effects. Meanwhile, the blood sugar and liver glycogen levels of animals are raised, and in-vivo protein decomposition is also reduced, which is shown by the reduction of the rise of the blood urea nitrogen level, so that the traditional Chinese medicine liquid has the effects of improving the blood sugar and myoglycogen levels of swimming animals and reducing in-vivo protein decomposition, thereby effectively delaying the occurrence of fatigue.

4. The invention relates to a human body test feeding test for improving sleep by using a traditional Chinese medicine liquid

By adopting two control designs between the self and the group, 60 simple patients suffering from insomnia for a long period are selected, the ages of the patients are 18 to 60 years, 30 patients are randomly divided into test feeding groups and control groups according to the symptom, the average ages of the 30 patients in the test feeding groups are 13 patients in the male group and 17 patients in the female group, the average ages of the patients in the control group are 52.75+/-10.25 years, the average ages of the patients in the male group and the female group 15 are 51.26+/-9.79. Test feeding group: the placebo was taken in the control group with the same appearance, color, weight and administration method as in the present invention with the administration of the Chinese medicinal liquid prepared in example 2 of the present invention. The subjects took 30ml each time 3 times daily per person. Normal diet is carried out during the test period without changing the original dietary habit, and other medicines and traditional Chinese medicine compositions for treating insomnia are stopped, and the observation period is 90 days.

Symptom integration observation: the integral is accumulated according to the light and heavy conditions of insomnia symptoms (3 points for severe symptoms, 2 points for moderate symptoms and 1 point for mild symptoms). The two symptom scores were not significantly different before treatment (P > 0.05). Before the test, the blood, urine, stool, liver and kidney functions, chest X-ray, electrocardiogram, B ultrasonic and other tests are all in the normal range.

The comparison between the test food group before and after test food and the comparison between the control groups obviously reduces the integral of clinical symptoms (P is less than 0.01), the sleep condition of the test food group crowd is obviously improved, no other side effect is reported, and the traditional Chinese medicine composition has the function of improving sleep. The results are shown in Table 4.

TABLE 4 integration of clinical symptoms before and after ingestion of the test meal

* P < 0.01 compared to before trial; ^## comparing between groups, P is less than 0.01.

5. Clinical trial of children with the Chinese medicinal liquid

Example 2 of the regimen of the present invention was tested by 32 teenagers, aged 12-19 years, with the following results:

1. basic conditions: in total, 32 teenagers mostly basically accord with the range of heart-spleen deficiency syndrome in the "reference standard for diagnosis and treatment of deficiency syndrome in traditional Chinese medicine" (revised in 5 month in 1986), but the symptoms are lighter. All the drug users were randomly divided into two groups, 16 oral liquid groups (example 2) and 16 control (syrup) groups.

2. The treatment method comprises the following steps: the oral liquid group and the control group are orally taken twice a day, 30ml each time, and the treatment course is 30 days.

3. Curative effect judgment criteria: the heart-spleen deficiency mostly has deficiency symptoms such as listlessness, systemic debilitation, reaction retardation, dreaminess, amnesia, anorexia and the like, and the curative effect judgment standard is formulated according to the reduction degree of the related symptoms after the teenagers try.

(1) The effect is shown: the symptoms and signs are obviously improved.

(2) The method is effective: the symptoms and signs are all improved.

(3) Invalidation: symptoms or signs are not significantly improved or aggravated.

4. Statistical methods employ t-test and x 2 test.

5. Results

The clinical curative effects of the two groups of users are compared, the obvious effect is 14 out of 16 oral liquid groups, the effective rate is 2, the ineffective rate is 0, and the total effective rate is 100%; the control group has 0 cases of significant effect, 1 case of effective effect, 15 cases of ineffective effect, and the total effective rate is 6.25%. The data show that the total effective rate of the oral liquid group is greater than that of the control group, and the difference between the two groups has statistical significance (P < 0.001) through t test.

The traditional Chinese medicine component and the traditional Chinese medicine liquid with the intelligence improving effect are special traditional Chinese medicine oral liquid with multiple ways capable of improving learning efficiency, and have the following advantages:

1. enhancing learning and memory by improving amnesia;

2. by enhancing cerebral blood and oxygen supply, improving cerebral microcirculation, resisting fatigue, enhancing concentration of study, and improving stress and reaction capacity;

3. aiming at insomnia, the sleep quality is improved, and the learning efficiency is improved;

4. the product has effects of improving intelligence, strengthening brain, providing brain development substances and microelements, and being more beneficial to study;

5. good taste and is acceptable to students.

The invention has been described in detail with reference to preferred embodiments thereof. It should be understood that numerous modifications and variations can be made in accordance with the concepts of the invention by one of ordinary skill in the art without undue burden. Therefore, all technical solutions which can be obtained by logic analysis, reasoning or limited experiments based on the prior art by the person skilled in the art according to the inventive concept shall be within the scope of protection defined by the claims.

Claims

1. A traditional Chinese medicine formula with an intelligence improving effect is characterized in that: the traditional Chinese medicine is prepared from the following raw materials in parts by weight: 175-185 parts of polygala tenuifolia, 95-105 parts of dried rehmannia root, 95-105 parts of semen cuscutae, 145-155 parts of shizandra berry, 145-155 parts of rhizoma acori graminei, 95-105 parts of dragon bone, 145-155 parts of ligusticum chuanxiong, 95-105 parts of cortex lycii radicis, 75-85 parts of fructus chebulae, 75-85 parts of fructus phyllanthi, 145-155 parts of rhizoma anemarrhenae, 115-125 parts of rhodiola rosea, 145-155 parts of American ginseng, 45-55 parts of liquorice, 95-105 parts of poria cocos, 145-155 parts of spina date seed, 145-155 parts of angelica sinensis, 85-95 parts of lucid ganoderma, 95-105 parts of cortex albiziae, 115-125 parts of lily, 145-155 parts of Chinese yam, 45-55 parts of platycladi seed, 45-55 parts of radix salviae miltiorrhizae, 115-125 parts of radix polygonati officinalis, 145-155 parts of oyster, 95-105 parts of longan pulp, 95-105 parts of tortoise plastron glue and 145-155 parts of fructus alpiniae oxyphyllae.

2. The traditional Chinese medicine formula with the intelligence improving effect as claimed in claim 1, which is characterized in that: the traditional Chinese medicine is prepared from the following raw materials in parts by weight: 175-180 parts of polygala tenuifolia, 95-100 parts of radix rehmanniae, 95-100 parts of semen cuscutae, 145-150 parts of shizandra berry, 145-150 parts of rhizoma acori graminei, 95-100 parts of dragon bone, 145-150 parts of ligusticum chuanxiong, 95-100 parts of cortex lycii radicis, 75-80 parts of fructus amomi, 75-80 parts of fructus terminaliae, 75-80 parts of fructus phyllanthi, 145-150 parts of rhizoma anemarrhenae, 115-120 parts of rhodiola rosea, 145-150 parts of American ginseng, 45-50 parts of liquorice, 95-100 parts of poria cocos, 145-150 parts of spina date seed, 145-150 parts of angelica sinensis, 85-90 parts of ganoderma lucidum, 95-100 parts of cortex albiziae, 115-120 parts of lily, 145-150 parts of Chinese yam, 45-50 parts of platycladi seed, 45-50 parts of radix salviae miltiorrhizae, 115-120 parts of radix polygonati officinalis, 145-150 parts of oyster, 95-100 parts of longan pulp, 95-100 parts of tortoise plastron glue and 145-150 parts of fructus alpiniae oxyphyllae.

3. The traditional Chinese medicine formula with the intelligence improving effect as claimed in claim 1, which is characterized in that: the traditional Chinese medicine is prepared from the following raw materials in parts by weight: 180-185 parts of polygala tenuifolia, 100-105 parts of dried rehmannia root, 100-105 parts of semen cuscutae, 150-155 parts of shizandra berry, 150-155 parts of rhizoma acori graminei, 100-105 parts of dragon bone, 150-155 parts of ligusticum wallichii, 100-105 parts of cortex lycii radicis, 80-85 parts of fructus chebulae, 80-85 parts of fructus phyllanthi, 150-155 parts of rhizoma anemarrhenae, 120-125 parts of rhodiola rosea, 150-155 parts of American ginseng, 50-55 parts of liquorice, 100-105 parts of poria cocos, 150-155 parts of spina date seed, 150-155 parts of angelica sinensis, 90-95 parts of lucid ganoderma, 100-105 parts of cortex albiziae, 120-125 parts of lily, 150-155 parts of Chinese yam, 50-55 parts of platycladi seed, 50-55 parts of radix salviae miltiorrhizae, 120-125 parts of pickled ginseng, 150-155 parts of rhizoma polygonati, 150-155 parts of oyster, 100-105 parts of longan pulp, 100-105 parts of tortoise plastron glue and 150-155 parts of fructus alpiniae.

4. The traditional Chinese medicine formula with the intelligence improving effect as claimed in claim 1, which is characterized in that: the traditional Chinese medicine is prepared from the following raw materials in parts by weight: 180 parts of polygala tenuifolia, 100 parts of dried rehmannia root, 100 parts of semen cuscutae, 150 parts of schisandra chinensis, 150 parts of rhizoma acori graminei, 100 parts of dragon bone, 150 parts of ligusticum wallichii, 100 parts of cortex lycii radicis, 80 parts of fructus amomi, 80 parts of fructus phyllanthi, 150 parts of rhizoma anemarrhenae, 120 parts of rhodiola rosea, 150 parts of American ginseng, 50 parts of liquorice, 100 parts of poria cocos, 150 parts of semen zizyphi spinosae, 150 parts of angelica sinensis, 90 parts of lucid ganoderma, 100 parts of cortex albiziae, 120 parts of lily, 150 parts of rhizoma dioscoreae, 50 parts of platycladi seed, 50 parts of glossy privet fruit, 150 parts of radix salviae miltiorrhizae, 120 parts of radix ginseng, 150 parts of rhizoma polygonati, 150 parts of oyster, 100 parts of arillus longan, 100 parts of tortoise shell glue and 150 parts of fructus alpiniae oxyphyllae.

5. A traditional Chinese medicine liquid with an intelligence improving effect is characterized in that: the traditional Chinese medicine liquid is obtained by the method of decocting the traditional Chinese medicine formula according to any one of claims 1 to 4 by water, and the total water adding amount is calculated according to 3 to 5 times of the total weight of all the raw materials, and the decoction is carried out in two times.

6. The traditional Chinese medicine liquid with intelligence improving effect according to claim 5, wherein: the preparation method of the traditional Chinese medicine liquid is as follows:

(2) Decocting: boiling with strong fire, decocting with middle fire for 0.5 hr, adding fructus Alpinae Oxyphyllae, decocting for 0.5 hr, and pouring out the decoction; adding the residual water into the residue, decocting for the second time, boiling with strong fire, decocting with middle fire for 45 min, and pouring out the decoction;

(3) Standing and filtering: mixing the two decoctions, standing for 3 hr, and filtering with 200 mesh sieve; filtering the medicinal liquid, standing for 2 hr, and filtering the medicinal liquid with 200 mesh filter screen;

7. The Chinese medicinal liquid with intelligence improving effect as claimed in claim 6, wherein: the method further comprises the step (5) of adding a flavoring agent after the step (4), wherein the flavoring agent is one or a combination of more of a sweetener, a flavoring agent, a mucilage and an effervescent agent; the flavoring agent is a combination of an effervescent agent and a sweetener, wherein the effervescent agent is sodium bicarbonate powder, the sweetener is neotame, the sodium bicarbonate powder is added first, and when the foam in the medicinal juice is dispersed, the neotame is added; 2-10 parts of baking soda powder and 1-6 parts of neotame.

8. The traditional Chinese medicine liquid with intelligence improving effect according to claim 7, wherein: the method further comprises the step (6) of adding a preservative after the step (5), wherein the preservative is potassium sorbate, and the potassium sorbate is 1-10 parts by weight.

9. The traditional Chinese medicine liquid with intelligence improving effect according to claim 8, wherein: and (3) filling in the step (7) after the step (6), obtaining concentrated solution when the medicine juice is concentrated to 34-35% of the volume of the filtered medicine juice, stopping heating, placing the concentrated solution in a paste filling machine when the temperature of the medicine juice is reduced to 60 ℃, and filling into a sterilized oral liquid bottle.

10. A pharmaceutical preparation with intelligence improving effect is characterized in that: the pharmaceutical preparation is prepared by adding the traditional Chinese medicine liquid according to any one of claims 5 to 9 into auxiliary materials commonly used in pharmacy; the dosage form of the pharmaceutical preparation belongs to the oral pharmaceutical dosage form; the oral pharmaceutical dosage forms comprise sugar-coated tablets, film-coated tablets, enteric-coated tablets, capsules, oral liquid, syrup, buccal agent, granules, dripping pills, powder, ointment, suspension and powder.