CN109846962B - Traditional Chinese medicine composition for treating chronic urticaria - Google Patents
Traditional Chinese medicine composition for treating chronic urticaria Download PDFInfo
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Abstract
A Chinese medicinal composition for treating chronic urticaria comprises radix astragali, Hunan Tan plumula Nelumbinis powder, semen Phaseoli, radix Cynanchi Paniculati powder, and fructus Lycii. The chronic urticaria treated by the formula can effectively improve the deficiency of qi and blood, the deficiency of spleen and kidney and the accumulation of dampness in skin of a patient. Has effects in invigorating qi, nourishing blood, invigorating spleen, tonifying kidney, eliminating dampness, and relieving itching. It is also an innovative treatment for chronic urticaria.
Description
Technical Field
The invention relates to a traditional Chinese medicine preparation for treating urticaria, in particular to a traditional Chinese medicine composition for treating chronic urticaria.
Background
Urticaria is commonly known as rubella. The local edema reaction caused by the dilation of small blood vessels of skin and mucous membrane and the increase of permeability usually subsides within 2-24 hours, but new rash recurs. Some patients may be accompanied by nausea, headache, abdominal distension, diarrhea, abdominal pain, and shortness of breath, and the symptoms disappear after several days of treatment, and the rash is not repeated, which is called acute urticaria.
The wheal is temporarily completely or incompletely resolved after part of patients are treated, but the wheal is in a repeated attack state, and the person who occurs at least twice a week and continuously for more than 6 weeks is called chronic urticaria.
At present, the chronic urticaria treated by western medicine is mainly antihistamine medicine and hormone medicine, although the effect is quick, more serious adverse reaction is easy to occur, and the relapse is easy to occur after the medicine is stopped. The reason for easy recurrence is that the root cause of the disease is not found, which is the syndrome of traditional Chinese medicine. The overall view and treatment based on syndrome differentiation are the core of the treatment of diseases in traditional Chinese medicine. The traditional Chinese medicine has more methods for treating chronic urticaria, but the effects are slow. Because of the wide range of syndromes, the same syndrome can appear in different diseases, and the same syndrome type can be treated by the same prescription. The reason for this is also poor pertinence. The syndrome is the external macroscopic expression of the microscopic pathological changes of the human body, which is perceived by the human body by sense. Macroscopically blurred compared to microscopically. The problem with the current treatment of chronic urticaria is that it does not organically combine macroscopic and microscopic. The existing research results (most of patients with chronic urticaria have iron-deficiency anemia and the oxidation resistance is reduced) are not well applied to the traditional Chinese medicine treatment; drugs with strong oxidation resistance and rich iron are not well applied to the treatment of chronic urticaria; modern research on traditional Chinese medicines is not well applied to processing and extraction of the traditional Chinese medicines; neglecting the influence of insomnia, depression and blood stasis on treatment existing in the chronic urticaria patients.
Disclosure of Invention
The invention aims to: the traditional Chinese medicine composition for treating chronic urticaria, which overcomes the defects of the prior art, is capable of effectively treating or improving wet skin, qi deficiency, blood weakness and spleen and kidney deficiency of patients, and has the effects of tonifying qi and nourishing blood, invigorating spleen and kidney, removing dampness and relieving itching.
In order to achieve the purpose, the technical scheme adopted by the scheme is as follows:
a traditional Chinese medicine composition for treating chronic urticaria is prepared from the following raw materials: astragalus root, ledebouriella root, white atractylodes rhizome, ephedra down, capsule of weeping forsythia, lotus plumule powder, phaseolus calcaratus, white mulberry bark, prepared rehmannia root, white peony root, Chinese angelica root, root of red rooted saliva, safflower, lotus seed, bupleurum root processed with vinegar, fructus akebiae, albizia flower, paniculate swallowwort root powder, dittany bark, broom cypress fruit, dodder seed, cornus fruit processed with wine, smoked plum, schisandra fruit processed with vinegar, licorice root and black wolfberry fruit.
Further, the traditional Chinese medicine composition for treating chronic urticaria is prepared from the following components in parts by weight: 10-30g of astragalus membranaceus, 3-15g of divaricate saposhnikovia root, 6-25g of bran-fried bighead atractylodes rhizome, 6-25g of bran-fried rhizoma atractylodis, 1-6g of ephedra down, 3-10g of fructus forsythiae, 1-5g of Hunan Tabanum plumula nelumbinis powder, 10-35g of red bean, 5-15g of fried white mulberry root-bark, 5-20g of prepared rehmannia root, 5-15g of fried white paeony root, 6-25g of angelica sinensis, 5-15g of salvia miltiorrhiza, 3-10g of safflower, 6-25g of lotus seed, 6-20g of vinegar radix bupleuri, 6-20g of fructus akebiae, 10-30g of albizzia flower, 1-10g of paniculate swallowwort root powder, 6-25g of cortex dictamni, 10-30g of broom cypress fruit, 6-25g of salt semen cuscutae, 3-20g of cornus officinalis, 2-8g of dark plum, 2-10g of vinegar schisandra chinensis, 3-15g of liquorice, and the mixture of honey, 3-20g of lycium ruthenicum.
Furthermore, the traditional Chinese medicine composition for treating chronic urticaria can be prepared into an oral preparation according to the weight ratio and pharmaceutically acceptable carriers.
Further, the preparation of the traditional Chinese medicine composition for treating chronic urticaria comprises the following steps:
a. heating the pan, spreading testa Tritici, adding rhizoma Atractylodis tablet when smoking, continuously turning, taking out when it is dark yellow, sieving to remove testa Tritici, and cooling[1]。
Heating the pan, sprinkling testa Tritici, adding Atractylodis rhizoma tablet when smoking, stirring, parching until Atractylodis rhizoma is brown, sieving to remove testa Tritici,[1]。
soaking dried rehmanniae radix with 10% ethanol as liquid adjuvant for 16 h, steaming at 100 deg.C for 8 h, drying at 50 deg.C for 48 h to obtain steamed rehmanniae radix dry product, and repeatedly steaming under the same conditions for 7 times to obtain the final product[2]。
The pulp of fructus Corni is steamed according to the rules of the four parts steaming method 0213 in 2015 th edition of pharmacopoeia of people's republic of China until the wine is completely absorbed.
Taking herba Ephedrae, grinding down, and sieving to remove powder[3]。
Mixing bupleuri radix tablet with vinegar, stirring, slightly stewing, parching with slow fire, taking out, cooling[4]。
Salted semen cuscutae: parching semen Cuscutae with slow fire to slight yellow and slight popping, adding saline water, stirring, parching to dry, taking out when fragrance is given out, and cooling[5]。
Moxibustion of white mulberry root-bark: diluting Mel with a small amount of boiled water, spraying into cortex Mori, stirring, slightly stewing, parching with slow fire to golden yellow, taking out, cooling[6]。
b. Xiangtan lotus plumule powder: the fine powder is prepared into fine powder according to the requirement of ' measuring ' under the item of ' pharmacopoeia of the people's republic of China ' 2015 edition.
Paniculate swallowwort root powder: the fine powder is prepared into fine powder according to the requirement of ' measuring ' under the item of ' pharmacopoeia of the people's republic of China ' 2015 edition.
c. Pulverizing dried fructus Lycii, soaking in water of 60 deg.C, extracting twice, and mixing the two extractive solutions.
d. Because the iron content in the dodder and the bupleurum is particularly high[7]Is very beneficial to the treatment of chronic urticaria[8]. In order to preserve the effective component of ferrum to the maximum extent and prevent the loss of ferrum due to the absorption of the effective component and other medicines when the effective component and other medicines are decocted, the salt dodder and the vinegar-processed radix bupleuri are separately combined and decocted with water for extraction twice.
e. Except for the salt semen cuscutae, the vinegar radix bupleuri, the lycium ruthenicum, the Hunan pond lotus plumule powder and the paniculate swallowwort root powder, the other medicines are mixed and decocted with water for extraction twice.
f. When the two parts of water-decocted and extracted liquid medicine are cooled to below 60 ℃, the liquid medicine and the extracted black Chinese wolfberry liquid medicine with the temperature of 60 ℃ are uniformly mixed together and are naturally cooled for standby.
Furthermore, the traditional Chinese medicine composition for treating chronic urticaria is taken twice in the morning and at night, and the Hunan Tan lotus plumule powder and the paniculate swallowwort root powder are divided into two parts in the same way, and are taken together with the liquid medicine for two times.
The invention has the beneficial effects that: the chronic urticaria treated by the formula can effectively improve the deficiency of qi and blood, the deficiency of spleen and kidney and the accumulation of dampness in skin of a patient. Has effects in invigorating qi, nourishing blood, invigorating spleen, tonifying kidney, eliminating dampness, and relieving itching. It is also an innovative treatment for chronic urticaria.
The implementation, functional features and advantages of the objects of the present invention will be further explained with reference to the embodiments.
Detailed Description
Now, with reference to typical cases, the following are specified:
the traditional Chinese medicine composition for treating chronic urticaria comprises the following components in parts by weight: 20g of astragalus mongholicus, 10g of divaricate saposhnikovia root, 20g of bran-fried bighead atractylodes rhizome, 10g of bran-fried rhizoma atractylodis, 6g of ephedra down, 9g of fructus forsythiae, 3g of Hunan Tan lotus plumule powder, 20g of phaseolus calcaratus, 10g of fried white mulberry root-bark, 9g of prepared rehmannia root, 15g of fried white paeony root, 15g of Chinese angelica, 10g of salvia miltiorrhiza, 5g of safflower carthamus, 15g of lotus seed, 10g of vinegar radix bupleuri, 10g of fructus akebiae, 10g of albizia flower, 4g of paniculate swallowwort root powder, 15g of cortex dictamni, 10g of fructus kochiae, 10g of common dodder seed, 10g of wine cornus, 5g of dark plum fruit, 5g of vinegar schisandra chinensis, 9g of liquorice and 8g of black wolfberry.
Furthermore, the traditional Chinese medicine composition for treating chronic urticaria can be prepared into an oral preparation according to the weight ratio and pharmaceutically acceptable carriers.
Further, the preparation of the traditional Chinese medicine composition for treating chronic urticaria comprises the following steps:
a. heating the pan, spreading testa Tritici, adding rhizoma Atractylodis tablet when smoking, continuously turning, taking out when it is dark yellow, sieving to remove testa Tritici, and cooling[1]。
Heating the pan, sprinkling testa Tritici, adding Atractylodis rhizoma tablet when smoking, stirring, parching until Atractylodis rhizoma is brown, sieving to remove testa Tritici,[1]。
soaking dried rehmanniae radix with 10% ethanol as liquid adjuvant for 16 h, steaming at 100 deg.C for 8 h, drying at 50 deg.C for 48 h to obtain steamed rehmanniae radix dry product, and repeatedly steaming under the same conditions for 7 times to obtain the final product[2]。
The pulp of Corni fructus is steamed according to the method of steaming four parts of wine (general rule 0213) of 2015 th pharmacopoeia of people's republic of China until the wine is absorbed completely.
Taking herba Ephedrae, grinding down, and sieving to remove powder[3]。
Mixing bupleuri radix tablet with vinegar, stirring, slightly stewing, parching with slow fire, taking out, cooling[4]。
Salted semen cuscutae: parching semen Cuscutae with slow fire to slight yellow and slight popping, adding saline water, stirring, parching to dry, taking out when fragrance is given out, and cooling[5]。
Moxibustion of white mulberry root-bark: diluting Mel with a small amount of boiled water, spraying into cortex Mori, stirring, slightly stewing, parching with slow fire to golden yellow, taking out, cooling[6]。
b. Xiangtan lotus plumule powder: the fine powder is prepared into fine powder according to the requirement of ' measuring ' under the item of ' pharmacopoeia of the people's republic of China ' 2015 edition.
Paniculate swallowwort root powder: the fine powder is prepared into fine powder according to the requirement of ' measuring ' under the item of ' pharmacopoeia of the people's republic of China ' 2015 edition.
c. Pulverizing dried fructus Lycii, soaking in water of 60 deg.C, extracting twice, and mixing the two extractive solutions.
d. Because the iron content in the dodder and the bupleurum is particularly high[7]Is very beneficial to the treatment of chronic urticaria[8]. In order to preserve the effective component of ferrum to the maximum extent and prevent the loss of ferrum due to the absorption of the effective component and other medicines when the effective component and other medicines are decocted, the salt dodder and the vinegar-processed radix bupleuri are separately combined and decocted with water for extraction twice.
e. Except for the salt semen cuscutae, the vinegar radix bupleuri, the lycium ruthenicum, the Hunan pond lotus plumule powder and the paniculate swallowwort root powder, the other medicines are mixed and decocted with water for extraction twice.
f. When the two parts of water-decocted and extracted liquid medicine are cooled to below 60 ℃, the liquid medicine and the extracted black Chinese wolfberry liquid medicine with the temperature of 60 ℃ are uniformly mixed together and are naturally cooled for standby.
Furthermore, the traditional Chinese medicine composition for treating chronic urticaria is taken twice in the morning and at night, and the Hunan Tan lotus plumule powder and the paniculate swallowwort root powder are divided into two parts in the same way, and are taken together with the liquid medicine for two times.
Description of the treatment method:
the spleen and stomach are the acquired root and the source of qi and blood. Spleen qi deficiency can not nourish the bones of the five zang organs, six fu organs, four limbs and bones well because of insufficient ability of transporting and transforming food essence; qi can produce blood, and deficiency of qi can lead to blood deficiency. Skin is malnutrition and pruritus due to blood deficiency. The spleen also has the function of transporting and resolving water-dampness. Spleen deficiency can not transport and resolve water dampness well, and the skin is itching due to dampness accumulation, so spleen strengthening, dampness eliminating and itching relieving are needed; kidneys also are the innate root. The non-innate qi of the spleen fails to transform into the innate qi, and the non-acquired qi of the kidney fails to grow. Kidney deficiency, which is apt to cause withered and lusterless skin, and therefore, kidney-tonifying and essence-securing are essential; the lung governs fur, and the lung is the mother of kidney, so it astringes lung and nourishes kidney; the pruritus, insomnia and anxiety of the patient with chronic urticaria are most likely to cause hyperactivity of heart-fire. Long-lasting disease causing stasis[9]. Zhu Danxi suggests that "the depression is caused by chronic disease" and the depression is caused by chronic disease ". So it is used with the assistant drugs of clearing heart fire and tranquilizing mind, soothing liver and regulating qi, and promoting blood circulation to remove blood stasis.
In addition, an oxidation and oxidation resisting system exists in the organism under normal conditions, and more researches show that the oxidative stress is related to various inflammatory skin diseases, and the urticaria belongs to the special type of inflammatory skin diseases. The serum antioxidant enzyme SOD activity of patients with urticaria in both acute stage and chronic stage is obviously reduced compared with that of normal control group, and MDA is obviously increased compared with that of normal control group. Therefore, the pathogenesis of urticaria is the imbalance of oxidation and oxidation resistanceInflammation is associated with immune disorders and antioxidant effects will contribute to anti-inflammation. Therefore, aiming at the reduction of the antioxidant capacity of the patients suffering from urticaria, the antioxidant should be given while the antiallergic treatment is carried out, so that the antioxidant capacity of the patients is improved[10]。
A causal relationship exists between low iron and spontaneous chronic urticaria, and the treatment effect of supplementing iron to patients is obvious[11]. Therefore, the supplement of antioxidant and iron agent is an indispensable means for treating chronic urticaria.
Prescription and medicine specification:
in the formula, the astragalus, the divaricate saposhnikovia root and the white atractylodes rhizome fried with bran are the components of the jade screen powder, so as to achieve the effects of benefiting wei and strengthening exterior; ephedra herb velvet, weeping forsythia, red bean and roasted white mulberry root-bark have the effects of ventilating the lung, promoting diuresis and eliminating dampness; radix rehmanniae Preparata, radix Paeoniae alba preparata, radix Angelicae sinensis and Saviae Miltiorrhizae radix have effects of nourishing blood, moistening skin and relieving itching; the vinegar radix bupleuri and the fructus akebiae are used for soothing the liver and regulating qi, and relieving liver depression to ensure the function of smoothing flow of the liver; bran-fried rhizoma atractylodis and bran-fried rhizoma atractylodis macrocephalae have the effects of tonifying qi, strengthening spleen and eliminating dampness to provide qi and blood for biochemical transformation, and meanwhile, cortex dictamni, fructus kochiae and paniculate swallowwort root have the effects of dispelling wind, removing dampness and relieving itching to prevent pruritus caused by spleen deficiency and dampness accumulation; if the kidney is affected by long-term consumption of qi and blood, which leads to withered and lusterless skin, then the salt dodder seed and the wine cornus fruit tonify liver and kidney and secure essence. The lycium ruthenicum murr has the effects of nourishing liver and kidney, clearing away heart heat, improving eyesight and invigorating stomach; meanwhile, the lotus seed and the Hunan pond lotus plumule powder have the effects of tonifying kidney and securing essence, communicating heart and kidney, calming heart and soothing nerves, so that the problem of sleep uneasiness caused by the chronic urticaria and the pruritus at night is solved; lung governs skin and hair, lung is the mother of kidney, dark plum fruit and vinegar schisandra fruit astringe lung and nourish kidney; after long-term treatment, blood stasis is removed, and the safflower promotes blood circulation to remove blood stasis; albizia julibrissin dura will soothe the nerves and relieve depression. Can be used for treating vexation, restlessness, depression, amnesia, and insomnia of chronic urticaria. Licorice root, radix Glycyrrhizae coordinates the effects of the other drugs in the recipe.
The iron content in dodder and bupleurum is particularly high[12]. For the patients with low-iron chronic urticaria, the traditional Chinese medicine composition can supplement iron deficiency and can also sooth liver and tonify kidney. Therefore, the application of the two medicines can play an unexpected effect on the treatment of the patients with chronic urticaria.
Xiangtan lotus plumule is bitter in taste and cold in nature. Has the effects of clearing away heart-fire and relieving restlessness. Determining antioxidant activity of ethanol extract of plumula Nelumbinis of 9 different production places by DPPH free radical scavenging method and Oxygen Radical Absorption Capacity (ORAC) methodThe comprehensive evaluation shows that the lotus plumule ethanol extract in Hunan quan producing area shows the strongest antioxidant capacity in two evaluation systems[13]。
Therefore, the lotus plumule in Hunan quan producing area is selected as the raw material. In order to avoid the loss of alcohol-soluble components caused by water decoction and ensure that the alcohol-soluble components are dissolved out to the maximum extent, the alcohol-soluble components are ground into powder and added into the decocted liquid medicine to exert the drug effect to the maximum extent. Thereby exerting the strongest antioxidation effect. Therefore, the traditional Chinese medicine composition has an unexpected effect on the treatment of chronic urticaria.
The lycium ruthenicum murr fruits have the functions of strengthening kidney, moistening liver, improving eyesight and invigorating stomach, and can also be used for treating heart heat disease, heart disease, irregular menstruation and the like [14]. Therefore, the lycium ruthenicum murr has various effects of nourishing liver and kidney, clearing away heart heat, improving eyesight, invigorating stomach and the like. The spleen is exterior-interior, so it is good for invigorating stomach and spleen. Therefore, the traditional Chinese medicine is more suitable for treating spleen and kidney deficiency and vexation of patients with chronic urticaria.
The lycium ruthenicum contains various antioxidant substances and has good antioxidant effect[14]。
Proved by research, the lycium barbarum polysaccharide has very obvious effect of eliminating hydroxyl free radicals[15]. Comparing the DPPH free radical scavenging ability of the Lycium ruthenicum Murr water extract and the Lycium ruthenicum Murr water extract with different concentrations, the result shows that the Lycium ruthenicum Murr water extract has good free radical scavenging ability from low concentration, the free radical scavenging ability is very low when the concentration of the Lycium ruthenicum Murr water extract is low, and the scavenging ability is still far lower than that of the Lycium ruthenicum Murr water extract when the concentration of the extract reaches 1mg/ml[16]。
Research shows that the oxidation resistance of the liquid medicine obtained by the lycium ruthenicum at different brewing temperatures, times and time is found to be about 30min, the temperature is preferably 60-90 ℃, and the times are not suitable for much[17]. Therefore, the lycium ruthenicum murr liquid extracted at the temperature of 60 ℃ is properly added when the temperature of other liquid medicines is reduced to about 60 ℃. Thus, the active antioxidant ingredients are prevented from being damaged as much as possible, and the antioxidant can exert the strongest antioxidant activity. Also for the oxidation imbalance caused by the reduction of the oxidation resistance of the patient with chronic urticariaAnd a better correction effect is achieved. Further has the effect of treating inflammation and immune disorder of the chronic urticaria patients, and also has unexpected treatment effect on the treatment of the chronic urticaria.
Lipid peroxidation is a series of harmful oxidation reactions caused by oxygen free radicals attacking polyunsaturated fatty acids in biological membranes in vivo, most of which are produced by liver cells, and the decomposition of which is also mainly in the liver. When the generation of free radicals in vivo is increased, a series of lipid peroxides can be generated, MDA is the final product of the lipid peroxides initiated by the free radicals, and the higher the content of MDA is, the higher the lipid peroxidation degree of cell membranes is, and the more serious the damage of the cell membranes is. Research shows that the triterpenoid saponin as the main component in the fructus Akebiae has strong in vitro anti-lipid peroxidation and erythrocyte hemolysis effects and has a certain dose-effect relationship[18]. In the recipe, it is predicted that Zhi Zi enters liver and stomach meridians. To soothe the liver, regulate qi, dissipate nodulation and induce diuresis. Can relieve stagnation of liver-qi of patients with chronic urticaria, and promote diuresis. Its anti-lipid peroxidation effect can correct the oxidative imbalance of patients with chronic urticaria. The traditional Chinese medicine composition has an unexpected treatment effect on patients with chronic urticaria.
Research shows that 5-HMF can reduce the content of LDH in serum of a myocardial ischemia mouse and reduce the content of MDA in myocardial tissue of the myocardial ischemia mouse, and the research proves that the 5-HMF has the effect of resisting myocardial ischemia and has good antioxidation. The content of 5-HMF in the dogwood is obviously increased after the dogwood is steamed by wine. 5-HMF is separated from a dogwood wine product and identified, and the 5-HMF has a certain protection effect on the acute liver injury of mice. Meanwhile, the research also finds that 5-HMF is used for H2O2And vascular endothelial cell injury caused by glucose, and can reverse SOD activity decrease[19]. Therefore, the medicinal cornel has a protective effect on both heart and liver. The exuberance of heart qi is also beneficial to the recovery of spleen qi, and the protection of the liver is also beneficial to the exertion of the function of smoothing flow of liver qi. These are particularly advantageous for the treatment of chronic urticaria. In particular, it can reverse the activity reduction of SOD, and the antioxidant effect is important for adjusting the oxidation imbalance state of patients with chronic urticaria, and these can relieve or eliminate chronic urticariaInflammation and immune disorders in patients play unexpected roles.
The prepared rehmannia root has the effects of enriching blood and nourishing yin, and benefiting essence and replenishing marrow, and is used for treating a series of symptoms caused by blood deficiency and sallow complexion, palpitation, liver-kidney yin deficiency and the like. The 5-HMF content of radix rehmanniae Preparata steamed for 7 times under the specified conditions is 209 times of that of radix rehmanniae Preparata steamed for 2 times[20]. Therefore, the prepared rehmannia root also exerts stronger antioxidant activity. Therefore, the traditional Chinese medicine composition has an unexpected effect on treating chronic urticaria.
Paeonol is a small molecular phenolic compound extracted from cortex moutan, and has low melting point (mp 51 + -1 deg.C), high volatility and poor water solubility[21]. Paeonol is also the main active ingredient of Cynanchum paniculatum of Asclepiadaceae. It is used as a monomer component of plant medicine, and has strong antibacterial, antiinflammatory and antioxidant effects[22][23]. In addition, paeonol has effects in protecting liver and kidney, resisting arrhythmia, resisting allergy, protecting cardiovascular system, promoting blood circulation, and removing blood stasis[24][25]
In view of the physical properties of paeonol, if the paniculate swallowwort root is decocted with water, a large amount of active ingredients are lost. In order to preserve paeonol in radix Cynanchi Paniculati to the maximum extent, it is ground into powder and added into the decocted medicinal liquid for administration. Thus, the loss of paeonol is greatly reduced, and the functions of resisting inflammation, resisting oxidation, protecting liver and kidney, resisting arrhythmia, resisting allergy, protecting cardiovascular system, promoting blood circulation and removing blood stasis are exerted to the maximum extent, thereby having unexpected effect on treating chronic urticaria.
Stir-frying rhizoma atractylodis with bran: the raw rhizoma Atractylodis is pungent, warm, bitter and dry, and can be stir-baked with bran to relieve dryness, turn qi into fragrant, strengthen spleen invigorating and dampness eliminating effects[26]. The effect of strengthening the spleen and eliminating dampness is enhanced, the effect of treating the chronic urticaria is certainly enhanced, and the traditional Chinese medicine composition is more suitable for patients with the chronic urticaria and the spleen deficiency and the excessive dampness. Thus, the unexpected therapeutic effect can be achieved.
Ephedra, herba Ephedrae has strong actions of inducing sweat, relieving exterior syndrome, inducing diuresis and relieving edema. However, excessive sweating may cause yin injury and yang exhaustion, so it is not suitable for weak people. The herba Ephedrae is made into herba Ephedrae velvet with slow action[27]. Is more suitable for patients with chronic urticaria with weak constitution. Make the medicineWalk out of the body without causing strong sweating. Therefore, the Chinese ephedra made into the Chinese ephedra down has unexpected treatment effect on the chronic urticaria.
Raw chaihu has strong effect of ascending and dispersing, and is suitable for relieving exterior syndrome and bringing down fever. Vinegar processed can alleviate ascending and dispersing property and enhance the actions of soothing liver and regulating qi. Is more suitable for liver depression and qi stagnation[28]. Therefore, the better treatment effect can be achieved.
Moxibustion of white mulberry root-bark: raw sang Bai Pi is cold in nature and strong in action of purging lung and promoting diuresis, and stir-baked with honey with cold and moist in nature can alleviate cold diarrhea[29]. Avoid impairment of healthy qi due to excessive lung purging, and is more suitable for patients with chronic urticaria with weak constitution. Compared with the raw product, the Chinese medicinal composition has the obvious unexpected treatment effect.
The research shows that the activity of SOD in the serum of the rat with anxiety and depression-like behaviors is obviously reduced, and the content of MDA is obviously increased[30]。
Pruritus is the most intolerable of patients with chronic urticaria, and seriously affects the sleep of the patients. Clinical studies have shown that sleep deprivation is closely associated with a negative emotional state, and prolonged sleep deficits can lead to pathological anxiety in humans. People with 24 h sleep deprivation have a positive decrease in mood and an increase in negative mood compared to normal sleeping people. While a healthy volunteer with 56 h of continuous sleep deprivation increased anxiety, depression and paranoid symptoms[31]
The lack of sleep may cause anxiety and even aggravate the anxiety[32]. Animal experiments also show that compared with normal resting rats, 72h rats deprived of sleep until anxiety-like behavior have significantly reduced amygdala SOD, CAT (catalase) activity (P < 0.01 ) and BDNF expression (P < 0.01) [33]. A large number of researches show that the activity of SOD in the brain of depression patients is reduced, and the content of NO and MDA is obviously increased compared with that of a normal control group[34]。
All the results show that insomnia, depression and anxiety can cause the reduction of antioxidant capacity, and cause the failure of timely removal of excessive free radicals in the body to further cause damage to the human body. The clinical observation also shows that most of patients with chronic urticaria have the symptoms of liver qi depression, which is also related to pruritus and insomnia caused by pruritus. These factors in turn further reduce the patient's antioxidant capacity. Therefore, chronic urticaria is lingering and difficult to cure. Insomnia, depression and anxiety are often overlooked, so that it is important to correct insomnia, depression and anxiety of patients with chronic urticaria.
Modern pharmacological research shows that the albizia flower decoction has obvious sedative hypnotic and antidepressant activity[35]The sedative-hypnotic effect of the medicine is stronger than that of the spina date seed[36]. The ability of flavones to penetrate blood brain screens allows flavones to have a wide range of central nervous system effects. Flos Albizziae total flavone and quercetin as main ingredient of the total flavone have anxiolytic effect[37]. Flos Albizziae total flavone with antidepressant effect[38]Quercetin has effects in scavenging multiple active oxygen free radicals[39]
The cerebral cortex is the central integration of various sensory signals input, and the hypothalamus maintains homeostasis by regulating neuroendocrine network, both of which contain the inhibitory neurotransmitter GABA, which is a major neurotransmitter in maintaining normal sleep, closely related to insomnia. The flos Albizziae total flavone extract can improve brain histopathological and histological structure of insomnia rat, increase GABA content in hypothalamus and cerebral cortex of insomnia model rat, and promote neurotransmitter expression in hypothalamus and cerebral cortex of insomnia model rat[40]。
BDNF is a protein widely existing in central nervous system, can improve pathological state of neuron, and has important effects on survival, differentiation, growth and development of neuron[41] Research reports that BDNF can enhance the antioxidant capacity of brain by enhancing the activity of superoxide dismutase SOD[42]。
Albizzia julibrissin total flavonoids promote endogenous expression of hippocampus BDNF and receptor Trk B of depression model rat after chronic stress, thereby regulating hippocampal neuron plasticity and protecting hippocampal neurons[43]。
Therefore, insomnia, depression, anxiety and reduction of antioxidant capacity caused by pruritus of patients with chronic urticaria are all connected and not negligible. The albizia flower is a Chinese medicine with the functions of tranquilizing, allaying excitement, resisting depression and resisting oxidation. And can improve the histopathological structure of brain caused by insomnia. The treatment for the patient with chronic urticaria obviously has unexpected effect.
Typical cases are:
case 1: wangzhi, female, 43 years old, salesperson. The diagnosis is made in 2016, 03 and 08 days with "wind mass with pruritus half a year". The patient repeatedly appears wheezy mass and erythema all over the body for half a year, and the wheeze mass and erythema disappear with pruritus at the time of day, which is particularly obvious at night, and the chronic urticaria is determined by western medicine. Many antihistamine drugs such as chlorpheniramine maleate, cetirizine tablets and mizolastine capsules have been taken orally, which is not good. Laboratory examination: RBC 1.92X 10-12The medium is prepared from the following raw materials of/L, SF 13.88.88 mu g/L, HGB70.40g/L, MCV65.73fL, MCHC22.20g/L, SOD 46.87U/mL and MDA 6.60 nmol/mL. Iron deficiency anemia[44]. The symptoms are as follows: lassitude, hypodynamia, inappetence, soreness of waist, scanty menstruation, pale menstruation, insomnia, pale tongue with greasy coating, deep and thready pulse, and belongs to the skin with symptoms of qi deficiency, blood weakness, spleen and kidney deficiency, and dampness accumulation. It is effective in invigorating qi, nourishing blood, invigorating spleen, tonifying kidney, eliminating dampness, and relieving itching. The traditional Chinese medicine decoction 6 for treating chronic urticaria is given to treat: 20g of radix astragali, 10g of radix sileris, 20g of bran-fried rhizoma atractylodis, 6g of ephedra down, 3g of forsythia, 6g of Xiangtan lotus plumule powder (taken with water), 3g of phaseolus calcaratus, 20g of roasted cortex mori, 9g of prepared rehmannia root, 5g of fried radix paeoniae alba, 10g of angelica, 15g of salvia miltiorrhiza, 6g of safflower, 10g of vinegar radix bupleuri (taken with water), 6g of fructus akebiae, 10g of flos albiziae, 10g of paniculate swallowwort root powder (taken with water), 4g of cortex dictamni, 10g of fructus kochiae, 10g of salt semen cuscutae (taken with water), 10g of wine pulp, 6g of fructus corni, 5g of vinegar fructus schizandrae, 9g of liquorice, 8g of black medlar, are decocted according to the stipulation and taken one dose every day. After 2 weeks, the symptoms of hypodynamia, pruritus and scanty menstruation are obviously improved. After the medicine is taken for 2 weeks, the symptoms of the patients are all moderate, the medicine is taken for 4 weeks by a guardian, and the skin of the patients has no erythema, no wheal and pruritus, and no other uncomfortable symptoms. Laboratory examination: RBC 4.43X 10-12/L、SF38.17µg/L、HGB 128.01g/L、MCV87.53 fL、MCHC 34.99g/L、SOD 49.48 U/ mL、MDA6.07 nmol/ mL。
Case 2: zheng and Cheng, male, 61 years old, retires. The diagnosis is made in 2016 (10 months and 01 days) because "the whole body cannot fall asleep often with pruritus for 1 year". The patient has repeated the whole body for 1 yearErythema and wheezy mass disappear in the course of time with pruritus, which is especially obvious at night, and is determined as chronic urticaria in Western medicine. Many antihistamine drugs and hormone drugs have been taken orally, and the effect is not good. Laboratory examination of RBC 1.51X 10-12/L, SF 12.01.01 μ g/L, HGB57.51 g/L, MCV55.31 fL, MCHC18.68 g/L, SOD41.00U/mL, MDA7.19 nmol/mL. Iron deficiency anemia[44]. The patients have no internal diseases, and the symptoms are as follows: lassitude, fatigue, anorexia, soreness of the waist, depression, insomnia, red tongue with greasy coating, fat tongue, deep pulse, and sticky stool. The syndrome belongs to qi deficiency and blood weakness, spleen and kidney deficiency and dampness accumulation in skin, and is used for tonifying qi and nourishing blood, strengthening spleen and tonifying kidney, and removing dampness and relieving itching. The traditional Chinese medicine decoction for treating chronic urticaria is given for treatment: 20g of radix astragali, 10g of radix sileris, 20g of bran-fried bighead atractylodes rhizome, 20g of bran-fried rhizoma atractylodis, 10g of ephedra down, 6g of fructus forsythiae, 9g of Hunan Tan lotus plumule powder (taken with water), 3g of phaseolus calcaratus, 20g of roasted cortex mori, 10g of prepared rehmannia root, 9g of fried radix paeoniae alba, 12g of radix angelicae sinensis, 10g of radix salviae miltiorrhizae, 5g of safflower, 15g of lotus seed, 15g of vinegar radix bupleuri (taken with water), 10g of fructus akebiae, 10g of flos albiziae, 10g of cynanchum paniculatum powder (taken with water), 4g of cortex dictamni, 15g of fructus kochiae, 10g of salt semen cuscutae (taken with water), 10g of wine pulp of fructus corni, 5g of vinegar fructus schizandrae, 9g of liquorice, 10g of black medlar, and one dose of decoction for each day. After 2 weeks, the patients have a relapse of treatment, and the appetite is poor, the waist is sore, the depression and insomnia are obviously relieved, and the red tongue and the tongue coating are relieved. The prescription is adjusted as follows: 20g of radix astragali, 10g of radix sileris, 20g of bran-fried bighead atractylodes rhizome, 20g of bran-fried rhizoma atractylodis, 10g of ephedra down, 3g of fructus forsythiae, 6g of Hunan Tan lotus plumule powder (taken with water), 2g of phaseolus calcaratus, 20g of roasted cortex mori, 10g of prepared rehmannia root, 6g of fried radix paeoniae alba, 10g of radix salviae miltiorrhizae, 10g of safflower, 5g of lotus seed, 12g of vinegar radix bupleuri (taken with water), 10g of fructus akebiae, 10g of flos albiziae, 10g of paniculate swallowwort root powder (taken with water), 4g of cortex dictamni, 15g of fructus kochiae, 10g of salt semen cuscutae (taken with water), 10g of wine fructus corni, 3g of vinegar fructus schizandrae, 5g of liquorice, 9g of black medlar and 10g of fructus lycii, and one dose of decoction of cornus officinalis per day is taken according to the regulation. Patients take the medicine for 3 weeks with all symptoms being moderate, and patients take the medicine continuously for 4 weeks with no erythema, wind mass and pruritus on the skin, and no other uncomfortable symptoms. Laboratory examination: RBC 4.03X 10-12/L、SF34.45µg/L、HGB116.99 g/L、MCV78.11fL、MCHC 31.30g/L、SOD46.27 U/ mL、MDA 6.64 nmol/ mL。
Case 3: lie, girl, age 22, college student. The diagnosis is made in 2017, 04 and 05 days after 2 months of "wind mass around the body with pruritus". The patient repeatedly generates wind in the whole body after 2 monthsThe mass and erythema are relieved in the morning and accompanied by pruritus, which is particularly obvious in afternoon and at night, and the Western medicine is determined to be chronic urticaria. The oral antihistamine medicine levocetirizine capsule and the Desloratadine citrate disodium tablet have better effect when being taken orally, and the symptom of stopping the medicine is as before. Laboratory examination: RBC 2.20X 10-12/L, SF 15.69.69 mug/L, HGB 83.10.10 g/L, MCV 76.11.11 fL, MCHC25.73 g/L, SOD50.79U/mL, MDA6.21 nmol/mL. Iron deficiency anemia[44]. The symptoms are as follows: lassitude, hypodynamia, inappetence, soreness of waist, pale menstruation, pale tongue with greasy coating, deep and thready pulse after menstruation, which are symptoms of qi deficiency, blood weakness, spleen and kidney deficiency, and damp accumulation in skin, and can be used for treating qi invigorating, blood nourishing, spleen invigorating, kidney invigorating, dampness eliminating, and itching relieving. The traditional Chinese medicine decoction for treating chronic urticaria is given for treatment: 15g of radix astragali, 6g of radix sileris, 6g of bran-fried bighead atractylodes rhizome, 15g of bran-fried rhizoma atractylodis, 6g of ephedra down, 3g of fructus forsythiae, 5g of Hunan Tan lotus plumule powder (taken with water), 3g of phaseolus calcaratus, 20g of roasted cortex mori, 9g of prepared rehmannia root, 5g of fried radix paeoniae alba, 10g of angelica sinensis, 12g of salvia miltiorrhiza, 6g of safflower, 10g of vinegar radix bupleuri (taken with water), 6g of fructus akebiae, 6g of flos albiziae, 10g of cynanchum paniculatum powder (taken with water), 3g of cortex dictamni, 10g of fructus kochiae, 10g of salt semen cuscutae (taken with water), 10g of wine pulp of cornus, 6g of fructus mume, 6g of vinegar fructus schisandrae, 6g of liquorice, 9g of black wolfberry and 8g of fructus lycii. The traditional Chinese medicine composition is decocted and taken according to the regulation, one dose is taken every day, the patient can be retested after 2 weeks, the fatigue, the pruritus and the menstruation are obviously improved after the menstruation is pushed, the patient can take the medicine for 2 weeks, all symptoms are relieved, the patient can take the medicine for 4 weeks after being conservative, the skin of the patient has no erythema, wheezy and pruritus, the skin lesion is completely disappeared, and no other uncomfortable symptoms exist. Laboratory examination: RBC 4.80X 10-12/L、SF41.88µg/L、HGB137.96 g/L、MCV96.77 fL、MCHC38.45 g/L、SOD 53.45 U/ mL、MDA 5.25 nmol/ mL。
Case 4: sunzhi, female, 28 years old, officer. The diagnosis is made in 2018, 03 and 08 days after the patient feels "the whole body after delivery with 1 year of pruritus". The patient repeatedly appears wheezy and red spot on the body after the child is born 1 year ago, and the patient is relieved in time with pruritus, which is particularly obvious at night, and the patient is determined as chronic urticaria by western medicine. Because of the concern that therapeutic drugs will have an effect on nursing children, no drug therapy is given. Laboratory examination: RBC 2.11X 10-12L, SF 14.81.81 mu g/L, HGB 76.11.11 g/L, MCV 70.28.28 fL, MCHC23.99 g/L, SOD 49.03.03U/mL and MDA 6.26 nmol/mL. Iron deficiency anemia[44]. The symptoms are as follows: lassitude, fatigue, anorexia, soreness of waistScanty menstruation, pale menstruation, poor sleep quality, pale tongue with greasy coating and deep and thready pulse, which belong to the symptoms of qi deficiency and blood weakness, spleen and kidney deficiency and dampness accumulation in skin, and are used for tonifying qi and nourishing blood, strengthening spleen and tonifying kidney, and removing dampness and relieving itching. The traditional Chinese medicine decoction for treating chronic urticaria is given for treatment: 20g of radix astragali, 10g of radix sileris, 20g of bran-fried rhizoma atractylodis, 6g of ephedra down, 3g of fructus forsythiae, 5g of Xiangtan lotus plumule powder (taken with water), 3g of phaseolus calcaratus, 20g of roasted cortex mori, 9g of prepared rehmannia root, 5g of fried radix paeoniae alba, 10g of radix angelicae sinensis, 12g of radix salviae miltiorrhizae, 6g of flos carthami, 3g of lotus seed, 10g of vinegar radix bupleuri (taken with water), 8g of fructus akebiae, 10g of flos albiziae, 10g of cynanchum paniculatum powder (taken with water), 10g of cortex dictamni, 10g of fructus kochiae, 10g of salt semen cuscutae (taken with water), 10g of wine pulp, 10g of fructus corni, 6g of vinegar fructus schizandrae, 5g of radix glycyrrhizae, 9g of black fructus lycii, and one dose of decoction for each day according to the stipulation. After 2 weeks, the symptoms of soreness of waist, inappetence, hypodynamia, pruritus and hypomenorrhea are obviously improved. The patient continued to take the medicine for 2 weeks with all the symptoms being moderate. The medicine is taken by the guardian for 4 weeks, the skin of the patient has no erythema, wheal and pruritus, the skin lesion is completely disappeared, and other uncomfortable symptoms do not exist. Laboratory examination: RBC 4.61X 10-12/L、SF40.06µg/L、HGB133.01 g/L、MCV92.01 fL、MCHC36.87 g/L、SOD 52.18U/ mL、MDA5.29 nmol/ mL。
Case 5: sunzhi, female, age 51, teacher. The diagnosis is made in 2018, 06 and 08 days "the perimenopausal wind mass is accompanied by pruritus for 1 year". The patients repeatedly appear wheezy mass and erythema around the postmenopausal period before 1 year, and the wheezy mass and erythema are relieved in time, the pruritus is particularly obvious at night, and the chronic urticaria is determined by western medicine. A plurality of antihistamine medicines such as chlorpheniramine maleate, cetirizine tablets, mizolastine capsules and the like have certain curative effect when being orally taken, but the wheal and the pruritus are generated after the medicines are stopped taking the medicine. Laboratory examination: RBC 1.65X 10-12L, SF 13.05.05 mu g/L, HGB 63.93.93 g/L, MCV60.59 fL, MCHC20.41 g/L, SOD 44.56U/mL and MDA6.77 nmol/mL. Iron deficiency anemia[44]. The symptoms are as follows: lassitude, hypodynamia, vexation, sweating, inappetence, soreness of waist, poor sleep quality, pale tongue with greasy coating, deep and thready pulse, and deficiency of qi and blood, deficiency of spleen and kidney, and dampness accumulation in skin, and can be used for treating qi deficiency, blood nourishing, spleen invigorating, kidney invigorating, dampness eliminating, and itching relieving. The traditional Chinese medicine decoction for treating chronic urticaria is given for treatment: 20g of radix astragali, 10g of radix sileris, 20g of bran-fried bighead atractylodes rhizome, 20g of bran-fried rhizoma atractylodis, 6g of ephedra down, 3g of fructus forsythiae, 3g of Hunan Tan lotus plumule powder (taken after being mixed with water) and 3g of phaseolus calcaratus20g of roasted white mulberry root-bark, 9g of prepared rehmannia root, 8g of fried white peony root, 10g of angelica, 12g of salvia, 6g of safflower, 3g of lotus seed, 10g of vinegar-prepared bupleurum (additionally decocted), 10g of fructus akebiae, 10g of albizzia flower, 10g of paniculate swallowwort root powder (taken with water), 4g of cortex dictamni, 10g of fructus kochiae, 10g of common dodder seed (additionally decocted), 10g of wine-prepared cornus fruit, 6g of dark plum, 5g of vinegar-prepared schisandra fruit, 5g of liquorice, 9g of black wolfberry and 6g of black wolfberry, and the decoction is taken one dose per day. After 2 weeks, the patients have poor sleep quality and vexation, and all the symptoms are slow after taking the medicine for 2 weeks. The medicine is taken by the guardian for 4 weeks, the skin of the patient has no erythema, wheal and pruritus, the skin lesion is completely disappeared, and other uncomfortable symptoms do not exist. Laboratory examination: RBC 4.21X 10-12/L、SF36.77µg/L、HGB122.87 g/L、MCV82.01 fL、MCHC33.21 g/L、SOD 47.90 U/ mL、MDA6.24 nmol/ mL。
Case 6: zhao, women, 60 years old, retire. The diagnosis is made in 2018, 10 and 12 days with the syndrome of wind mass with pruritus for 1 year after night. The patient repeatedly appears wheal and erythema in the whole body after entering the night for 1 year, and the wheal and erythema disappear with pruritus and fail to fall asleep normally, and the chronic urticaria is determined by western medicine. A plurality of antihistamine medicines such as chlorpheniramine maleate, cetirizine tablets, mizolastine capsules and the like have certain curative effect when being orally taken, but the wheal and the pruritus are generated after the medicines are stopped taking the medicine. Patients deny hypertension, diabetes and coronary heart disease. Laboratory examination: RBC 1.31X 10-12/L, SF 11.23.23 mug/L, HGB51.10 g/L, MCV50.09 fL, MCHC16.85 g/L, SOD 38.30U/mL, MDA7.41 nmol/mL. Iron deficiency anemia[44]. The symptoms are as follows: lassitude, hypodynamia, sweating, inappetence, soreness of waist, depression, vexation, poor sleep quality, pale tongue with greasy coating, fat tongue, deep and thready pulse, deficiency of qi and blood, deficiency of spleen and kidney, and dampness accumulation in skin, and can be used for treating qi invigorating, blood nourishing, spleen invigorating, kidney invigorating, dampness eliminating, and itching relieving. The traditional Chinese medicine decoction for treating chronic urticaria is given for treatment: 20g of radix astragali, 10g of radix sileris, 20g of bran-fried rhizoma atractylodis, 6g of ephedra down, 3g of forsythia, 3g of Xiangtan lotus plumule powder (taken with water), 3g of phaseolus calcaratus, 20g of roasted cortex mori, 9g of prepared rehmannia root, 5g of fried radix paeoniae alba, 10g of angelica, 13g of salvia miltiorrhiza, 6g of safflower, 10g of lotus seed, 10g of fructus akebiae, 10g of albizia flower, 10g of cynanchum paniculatum powder (taken with water), 4g of cortex dictamni, 10g of broom cypress fruit, 10g of semen cuscutae (taken with water), 10g of wine pulp, 6g of fructus corni, 5g of schisandra fruit, 5g of liquorice, 9g of black wolfberry and 6g of fructus lycii, and one dose of the decoction is taken according to the regulation and taken every day. After 2 weeks, the itching is relieved and the patient sleepsPoor quality and depression, vexation and restlessness are obviously improved, the patients take the medicine for 2 weeks, all symptoms of the patients are slow, the patients take the medicine for 4 weeks after keeping the prescription, the skin of the patients has no erythema, wheezy and pruritus, the skin lesions are completely disappeared, and no other uncomfortable symptoms exist. Laboratory examination: RBC 3.84X 10-12/L、SF32.53µg/L、HGB122.03 g/L、MCV73.00 fL、MCHC29.63 g/L、SOD43.01 U/ mL、MDA 6.57 nmol/ mL。
Reference documents:
[1] xuchu river, phylloding river, traditional Chinese medicine processing science [ M ]. shanghai: shanghai science and technology publishers, 1985,67,73.
[2] Influence of processing of rehmannia on catalpol and 5-hydroxymethylfurfural content [ J ] the J.Chinese J.2007, 32(12): 1155-supplement 1157.
[3] Xuchu river, phylloding river, traditional Chinese medicine processing science [ M ]. shanghai: shanghai science and technology Press, 1985,126.
[4] Xuchu river, phylloding river, traditional Chinese medicine processing science [ M ]. shanghai: shanghai science and technology Press, 1985,98.
[5] Xuchu river, phylloding river, traditional Chinese medicine processing science [ M ]. shanghai: shanghai science and technology Press, 1985,114.
[6] Xuchu river, phylloding river, traditional Chinese medicine processing science [ M ]. shanghai: shanghai science and technology Press, 1985,125.
[7] Menglan, mahongqiong, yanna, etc. content research of trace elements of iron, zinc, manganese and copper in 18 traditional Chinese medicines [ J ]. guangdong trace element science, 2008,15 (8): 47.
[8] progress of treatment of Luli, Wan Ping, chronic urticaria [ J ] medical theory and practice, 2017,30(8):1126.
[9] In Chengjian, the discussion of the mechanism and clinical application of "Jiu Biyu" in TCM will be appreciated [ J ]. the study of TCM, 1996, (2): 6-8.
[10] Zhaxu Chuan, Gao Yuli, detection of SOD and MDA in blood serum of patients with urticaria and its significance [ J ] China Mafeng dermatosis journal, 2008,24(1):41-42.
[11] Progress of treatment of Luli, Wan Ping, chronic urticaria [ J ] medical theory and practice, 2017,30(8):1126.
[12] Menglan, mahongqiong, yanna, etc. content research of trace elements of iron, zinc, manganese and copper in 18 traditional Chinese medicines [ J ]. guangdong trace element science, 2008,15 (8): 47.
[13] studies on antioxidant activity of lotus plumule and its partial chemical components in different production areas [ J ]. Chinese journal of traditional Chinese medicine, 2018,36(11):2696.
[14] Loushuting, study of active ingredients and volatile components of lycium ruthenicum [ D ]. hangzhou: zhejiang university, 2015: 12, 22.
[15] Chemical components and biological activity of the Chinese wolfberry fruit [ J ] the division of Chinese medicine and plant medicine, 2007,22(2):51.
[16] Black matrimony vine extract and red matrimony vine extract comparison of antioxidant effect [ J ] Jiangsu seasoning subsidiary food, 2018, (1): 32.
[17] loushuting, study of active ingredients and volatile components of lycium ruthenicum [ D ]. hangzhou: zhejiang university, 2015: 38-42.
[18] Hehaibo, Qinwen, Zengjianhong, etc. the research on the in vitro anti-lipid peroxidation and erythrocyte hemolysis of the triterpenoid saponin [ J ] Hubei agricultural science, 2016,55(7): 1758-.
[19] Study of the current state of research of fuziqin, wangming, cai baochang, 5-hydroxymethylfurfural (5-HM F) in traditional Chinese medicine [ J ]. a journal of chinese traditional medicine, 2008, 26 (3): 509-510.
[20] Influence of processing of rehmannia on catalpol and 5-hydroxymethylfurfural content [ J ] the J.Chinese J.2007, 32(12): 1155-supplement 1157.
[21] Sunweifeng, extraction of paeonol and research on pharmacological activity, Guangdong chemical industry, 2016,43(2):71-72.
[22] Influence of qijingsheng, lie, wang arene, paeonol on inhibition of osteoblast proliferation by peroxynitroso anion [ J ] the journal of chinese traditional and western medicine combination, 2003, 23 (2): 132-134.
[23] Sunweifeng paeonol extraction and pharmacological activity research progress [ J ]. Guangdong chemical industry, 2016,43(2): 71-71
[24] The pharmacological action research of the moustache, xu nationality, moutan bark and paeonol which is the main component of the moutan bark is developed [ J ]. Anhui medicine, 2014, 18(4): 589-.
[25] Sunweifeng, Paeonol extraction and pharmacological activity research progress [ J ]. Guangdong chemical industry, 2016,43(2):71-72.
[26] Xuchu river, phylloding river, traditional Chinese medicine processing science [ M ]. shanghai: shanghai science and technology publishers, 1985,67.
[27] Xuchu river, phylloding river, traditional Chinese medicine processing science [ M ]. shanghai: shanghai science and technology Press, 1985,126.
[28] Xuchu river, phylloding river, traditional Chinese medicine processing science [ M ]. shanghai: shanghai science and technology Press, 1985,98.
[29] Xuchu river, phylloding river, traditional Chinese medicine processing science [ M ]. shanghai: shanghai science and technology Press, 1985,125.
[30] Xiaoya, FIHUIZHI, Jianghui, etc. improving oxidative stress balance and reversing NET and 5-HTT expression abnormalities relates to the antidepressant action of venlafaxine [ J ] Chinese pharmacological report 2014, 30(6): 848 852.
[31] Exercise pre-intervention improves anxiety behavior in sleep deprived rats by enhancing amygdala antioxidant capacity and BDNF expression [ J ]. sheng yang sports college proceedings, 2016, 35 (3): 82.
[32] exercise pre-intervention improves anxiety behavior in sleep deprived rats by enhancing amygdala antioxidant capacity and BDNF expression [ J ]. sheng yang sports college proceedings, 2016, 35 (3): 80.
[33] exercise pre-intervention improves anxiety behavior in sleep deprived rats by enhancing amygdala antioxidant capacity and BDNF expression [ J ]. sheng yang sports college proceedings, 2016, 35 (3): 79-84.
[34] Oxidative stress is involved in the mechanism of acupuncture-mediated depression [ J ].2016, 18 (8): 1334-1340.
[35] Liurui, Limao, Xiebajun, etc. study of chemical composition of Albizzia julibrissin [ J ] Tianjin pharmacy, 2017,29 (6): 11.
[36] shiyihong, comparison of sedative and hypnotic effects of fruit decoction of Albizzia julibrissin and Nansheteng, Chinese medicinal materials 1989,12(5):36.
[37] Liuqian 20319Albizzia flower anxiolytic active substance basic research [ D ]. Beijing: beijing university of traditional Chinese medicine, 2015: 12,3.
[38] Zhangmin, research on antidepressant therapeutic action of flavone component of traditional Chinese medicine [ J ]. university of North China (Nature science edition), 2015,16(5):618.
[39] Herba polygoni capitatum chemical composition and antioxidant activity research [ J ] Chinese medicinal materials, 2008, 31 (7): 995-998.
[40] study on the spectrum-effect relationship between Liujiahui and flos Albiziae with sedative-hypnotic action [ D ]. Jinzhou, university of California medical science, 2017:43.
[41] The curative effect of levetiracetam on epilepsy and the influence on BDNF, CRP level and cognitive function of patients [ J ] experiment and test medicine, 2018,36(6):955.
[42] Exercise pre-intervention improves anxiety behavior in sleep deprived rats by enhancing amygdala antioxidant capacity and BDNF expression [ J ]. sheng yang sports college proceedings, 2016, 35 (3): 83.
[43] the influence of total flavonoids of albizia julibrissin durazzini, dongmeng, etc. on the BDNF and Trk B expression in the hippocampal CA3 region of depressed rats [ J ]. journal of chinese experimental prescriptions, 2013,19 (18): 198-201
[44] Zhang, Wittig. diagnostic and therapeutic criteria for hematological disorders [ M ] . scientific Press, 2007.
Claims (4)
1. A traditional Chinese medicine composition for treating chronic urticaria is characterized in that: the specific composition is prepared from the following raw materials: 10-30g of astragalus membranaceus, 3-15g of divaricate saposhnikovia root, 6-25g of bran-fried bighead atractylodes rhizome, 6-25g of bran-fried rhizoma atractylodis, 1-6g of ephedra down, 3-10g of fructus forsythiae, 1-5g of Hunan Tabanum plumula nelumbinis powder, 10-35g of red bean, 5-15g of fried white mulberry root-bark, 5-20g of prepared rehmannia root, 5-15g of fried white paeony root, 6-25g of angelica sinensis, 5-15g of salvia miltiorrhiza, 3-10g of safflower, 6-25g of lotus seed, 6-20g of vinegar radix bupleuri, 6-20g of fructus akebiae, 10-30g of albizzia flower, 1-10g of paniculate swallowwort root powder, 6-25g of cortex dictamni, 10-30g of broom cypress fruit, 6-25g of salt semen cuscutae, 3-20g of cornus officinalis, 2-8g of dark plum, 2-10g of vinegar schisandra chinensis, 3-15g of liquorice, and the mixture of honey, 3-20g of lycium ruthenicum.
2. The traditional Chinese medicine composition for treating chronic urticaria according to claim 1, is characterized in that: the traditional Chinese medicine composition for treating chronic urticaria can be prepared into an oral preparation according to a weight ratio and a pharmaceutically acceptable carrier.
3. The traditional Chinese medicine composition for treating chronic urticaria according to claim 1, is characterized in that: the preparation of the traditional Chinese medicine composition for treating chronic urticaria comprises the following steps:
a. heating a pot, scattering wheat bran, adding rhizoma Atractylodis tablets when smoking, continuously turning, taking out when the color is dark yellow, sieving to remove the wheat bran, and cooling;
heating a pan, scattering wheat bran, adding the bighead atractylodes rhizome slices when smoking, continuously stirring, frying until the bighead atractylodes rhizome is yellow brown, taking out, and screening off the wheat bran;
soaking dry rehmanniae radix with 10% ethanol as liquid adjuvant for 16 h, steaming at 100 deg.C for 8 h, drying at 50 deg.C for 48 h to obtain steamed rehmanniae radix dry product, and repeatedly steaming under the same conditions for 7 times to obtain the final product;
taking and steaming fructus Corni according to the rules of the four parts steaming method 0213 in 2015 edition of pharmacopoeia of people's republic of China until all the wine is absorbed;
grinding herba Ephedrae, and sieving to remove powder;
mixing bupleuri radix tablet with vinegar, slightly stewing, parching with slow fire, taking out, and cooling;
salted semen cuscutae: parching semen Cuscutae with slow fire to slight yellow with slight popping, adding saline water, stirring, parching to dry, taking out when fragrance is given out, and cooling;
moxibustion of white mulberry root-bark: diluting Mel with a small amount of boiled water, spraying into cortex Mori, stirring, slightly stewing, parching with slow fire to golden yellow, taking out, and cooling;
b. xiangtan lotus plumule powder: making into fine powder according to the requirement of ' measuring ' the fine powder in the first part of pharmacopoeia of the people's republic of China 2015 edition;
paniculate swallowwort root powder: making into fine powder according to the requirement of ' measuring ' the fine powder in the first part of pharmacopoeia of the people's republic of China 2015 edition;
c. pulverizing dried fructus Lycii, soaking in 60 deg.C water for two times, and mixing the two extractive solutions;
d. respectively mixing the salted semen Cuscutae and the vinegar-processed bupleuri radix, decocting with water and extracting twice;
e. except for the salt semen cuscutae, the vinegar radix bupleuri, the lycium ruthenicum, the Hunan pond lotus plumule powder and the paniculate swallowwort root powder, mixing the other medicines, decocting and extracting for two times;
f. when the two parts of water-decocted and extracted liquid medicine are cooled to below 60 ℃, the liquid medicine and the extracted black Chinese wolfberry liquid medicine with the temperature of 60 ℃ are uniformly mixed together and are naturally cooled for standby.
4. The traditional Chinese medicine composition for treating chronic urticaria according to claim 1, is characterized in that: the traditional Chinese medicine composition for treating chronic urticaria is taken twice in the morning and at night, and Hunan Tan lotus plumule powder and paniculate swallowwort root powder are divided into two parts in the same way, and the two parts are uniformly mixed with liquid medicine and taken.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6524627B1 (en) * | 2002-03-20 | 2003-02-25 | Daehan Biolink Co., Ltd. | Pharmaceutical composition for preventing and treating allergic diseases and a method for preparation thereof |
| CN102370914A (en) * | 2011-10-21 | 2012-03-14 | 马良玉 | Oral Chinese patent medicine pill for treating urticaria |
| CN105832875A (en) * | 2016-05-30 | 2016-08-10 | 孙慧 | Traditional Chinese medicine prescription for treating urticaria and preparation method thereof |
| CN108837054A (en) * | 2018-08-06 | 2018-11-20 | 陈洪涛 | A kind of Chinese herbal medicine beverage and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6524627B1 (en) * | 2002-03-20 | 2003-02-25 | Daehan Biolink Co., Ltd. | Pharmaceutical composition for preventing and treating allergic diseases and a method for preparation thereof |
| CN102370914A (en) * | 2011-10-21 | 2012-03-14 | 马良玉 | Oral Chinese patent medicine pill for treating urticaria |
| CN105832875A (en) * | 2016-05-30 | 2016-08-10 | 孙慧 | Traditional Chinese medicine prescription for treating urticaria and preparation method thereof |
| CN108837054A (en) * | 2018-08-06 | 2018-11-20 | 陈洪涛 | A kind of Chinese herbal medicine beverage and application thereof |
Non-Patent Citations (3)
| Title |
|---|
| 张士卿教授应用麻黄连翘赤小豆汤的经验;毋荣荣 等;《中医临床研究》;20131231;第5卷(第8期);第28-29页 * |
| 玉屏风过敏煎治疗慢性荨麻疹40例疗效观察;吴虹 等;《河北中医》;20030630;第25卷(第6期);第411-412页 * |
| 祛风调血汤治疗慢性荨麻疹30例;李军;《长春中医药大学学报》;20130228;第29卷(第1期);第151页右栏第2段、第152页左栏最后1段、右栏第1段 * |
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