CN116098981A - Medicinal and edible traditional Chinese medicine composition for reducing blood fat and preparation method thereof - Google Patents
Medicinal and edible traditional Chinese medicine composition for reducing blood fat and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to the technical field of traditional Chinese medicine compositions, and in particular relates to a medicinal and edible traditional Chinese medicine composition for reducing blood fat and a preparation method thereof. The composition comprises the following raw materials in parts by weight: 9-30 parts of codonopsis pilosula, 9-30 parts of astragalus membranaceus, 6-12 parts of stir-fried bighead atractylodes rhizome, 1-6 parts of cinnamon, 2-10 parts of honey-fried licorice root, 10-15 parts of poria cocos, 3-12 parts of fructus amomi, 3-9 parts of semen mesonae, 3-10 parts of dried orange peel, 5-10 parts of cattail pollen, 5-12 parts of stir-fried radish seeds, 9-12 parts of hawthorn, 3-9 parts of red yeast rice, 3-6 parts of fennel and 3-10 parts of ginger. The invention combines the traditional Chinese medicine theory and the modern medicine theory, solves the hyperlipidemia formed by the spleen-yang deficiency and the dampness accumulation and phlegm generation through tonifying qi and yang and strengthening spleen and drying dampness and phlegm, and simultaneously enhances the blood lipid reducing effect of the whole formula by using pollen typhae, red yeast rice and hawthorn. The components in the formula are medicinal and edible substances, and have no side effects.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicine compositions, and in particular relates to a medicinal and edible traditional Chinese medicine composition for reducing blood fat and a preparation method thereof.
Background
Hyperlipidemia is one of the most important pathogenic risk factors in the development of atherosclerotic cardiovascular disease. Because hyperlipidemia generally does not show symptoms, most people cannot pay attention to the hyperlipidemia, and the hyperlipidemia is western medicine or traditional Chinese medicine for reducing the blood lipid, so that the compliance of the administration is poor. The traditional Chinese medicine dosage forms such as powder, pills, granules and the like have larger volume, the dosage of each time is larger, the daily administration times are generally 2-3 times, people generally have difficulty in accepting the taste of the traditional Chinese medicine, and the administration is inconvenient. People generally worry about adverse reactions of western medicines, especially that most people are reluctant to take medicines when hyperlipidemia has no complications. However, if left free, the incidence of atherosclerotic cardiovascular disease due to hyperlipidemia increases. Therefore, the health food with the blood lipid reducing effect has certain application value and market prospect.
Based on the above, the Chinese medicinal materials with homology of medicine and food are used as raw materials, and the safe, effective and dual-purpose Chinese medicinal composition with the blood lipid reducing effect is developed from the dialectical of the traditional Chinese medicine and the modern western medicine theory, so that the rejection psychology of people on the medicines is reduced, and more choices are provided for the early-stage blood lipid regulation and control of patients with hyperlipidemia and the prevention of the occurrence of atherosclerosis cardiovascular diseases.
Traditional Chinese medicine considers that turbid phlegm retention is a common pattern of hyperlipidemia, spleen is a source of phlegm generation, and lung is a reservoir of phlegm. Because of spleen yang deficiency, clear people do not rise, turbid people do not fall, and phlegm dampness is generated, so phlegm dampness is formed.
Disclosure of Invention
The invention aims to provide a medicinal and edible traditional Chinese medicine composition for reducing blood fat and a preparation method thereof, and the medicinal and edible traditional Chinese medicine composition is used for treating hyperlipidemia formed by dampness accumulation and phlegm generation due to spleen-yang deficiency by tonifying qi, restoring yang, strengthening spleen, and eliminating dampness and phlegm.
In order to achieve the above object, the technical scheme of the present invention is as follows:
a medicinal and edible traditional Chinese medicine composition for reducing blood fat comprises the following raw materials in parts by weight: 9-30 parts of codonopsis pilosula, 9-30 parts of astragalus membranaceus, 6-12 parts of stir-fried bighead atractylodes rhizome, 1-6 parts of cinnamon, 2-10 parts of honey-fried licorice root, 10-15 parts of poria cocos, 3-12 parts of fructus amomi, 3-9 parts of semen mesonae, 3-10 parts of dried orange peel, 5-10 parts of cattail pollen, 5-12 parts of stir-fried radish seeds, 9-12 parts of hawthorn, 3-9 parts of red yeast rice, 3-6 parts of fennel and 3-10 parts of ginger.
In the technical scheme, the traditional Chinese medicine composition further comprises the following raw materials in parts by weight: 9-20 parts of codonopsis pilosula, 9-20 parts of astragalus membranaceus, 7-11 parts of stir-fried bighead atractylodes rhizome, 4-6 parts of cinnamon, 4-8 parts of honey-fried licorice root, 11-14 parts of poria cocos, 6-12 parts of fructus amomi, 5-9 parts of semen mesonae, 6-10 parts of dried orange peel, 6-10 parts of pollen typhae, 6-10 parts of stir-fried radish seeds, 10-12 parts of hawthorn, 6-9 parts of red yeast rice, 4-6 parts of fennel and 6-10 parts of ginger.
In the technical scheme, the traditional Chinese medicine composition further comprises the following raw materials in parts by weight: 9 parts of codonopsis pilosula, 9 parts of astragalus membranaceus, 9 parts of stir-fried bighead atractylodes rhizome, 6 parts of cinnamon, 6 parts of honey-fried licorice root, 12 parts of poria cocos, 12 parts of fructus amomi, 9 parts of semen mesonae, 10 parts of dried orange peel, 10 parts of pollen typhae, 10 parts of stir-fried radish seeds, 12 parts of hawthorn, 9 parts of red yeast rice, 6 parts of fennel and 10 parts of ginger.
In the technical scheme, the traditional Chinese medicine composition is further prepared into the dosage forms of granules, powder, medicinal granules or oral liquid.
The invention also provides a preparation method of the medicinal and edible traditional Chinese medicine composition for reducing blood fat, which comprises the following steps of:
(1) Mixing the raw materials uniformly according to the proportion, and soaking in cold water for 1-2 hours;
(2) Decocting for 40-60 min, and collecting filtrate;
(3) Lyophilizing the filtrate to obtain Chinese medicinal composition lyophilized powder;
(4) And (3) preparing the freeze-dried powder obtained in the step (3) into granules, powder, medicinal granules or oral liquid.
In the above technical scheme, in the step (1), the amount of cold water is 3 times of the total amount of the raw materials.
In the above technical scheme, in the step (3), the concentration of the lyophilized liquid medicine is 20%, the protective agent is 10% mannitol, and the pH value is 6-7; the freeze-drying process comprises the following steps: pre-freezing for 3 hours at the temperature of 40 ℃ below zero, then sublimating and drying for 14 hours at the temperature of 20 ℃ below zero, and finally resolving and drying for 10 hours at the temperature of 20 ℃ below zero, wherein the freeze-dried powder obtained under the process conditions has good formability and appearance.
The invention also provides an application of the medicinal and edible traditional Chinese medicine composition for reducing blood fat in preparation of a medicine for reducing blood fat.
The medicinal and edible lipid-lowering traditional Chinese medicine composition comprises the principal drugs of radix codonopsis pilosulae, radix astragali, stir-fried bighead atractylodes rhizome, honey-fried licorice root and cinnamon, and has the effects of tonifying qi, invigorating yang and strengthening spleen; the ministerial drugs comprise Poria, fructus Amomi, semen Brassicae Junceae, pericarpium Citri Tangerinae, and are effective in eliminating dampness, resolving phlegm and invigorating spleen; the adjuvant drugs include parched Raphani semen, fructus crataegi and red rice, and the adjuvant drugs include fructus Foeniculi and rhizoma Zingiberis recens for resolving food stagnation and relieving flatulence. Has the effects of tonifying qi, restoring yang, strengthening spleen, eliminating dampness and resolving phlegm. Meanwhile, the modern pharmacological researches show that the pollen typhae, the monascus purpureus and the hawthorn have good blood fat reducing effect.
The Chinese medicine of the invention adopts all medicinal and edible substances, and the codonopsis pilosula in the formula has the effects of strengthening spleen, benefiting lung, nourishing blood and promoting fluid production; astragalus mongholicus has the effects of tonifying qi and rising yang, and consolidating exterior and arresting sweating; the fried bighead atractylodes rhizome has the effects of strengthening spleen, tonifying qi, drying dampness and promoting diuresis; cinnamon can tonify fire, strengthen yang, induce fire to return to the original state, dispel cold and relieve pain; the honey-fried licorice root can tonify spleen and stomach, tonify qi and recover pulse; poria has effects of promoting diuresis, eliminating dampness, invigorating spleen, and calming heart; fructus Amomi has effects of eliminating dampness, stimulating appetite, warming spleen and relieving diarrhea; the meson warms lung, eliminates phlegm and promotes qi circulation; dried orange peel can regulate qi and invigorate spleen, dry dampness and resolve phlegm; pollen Typhae has effects of stopping bleeding, removing blood stasis, and treating stranguria; the stir-fried radish seeds can promote digestion and remove distention, and reduce qi and phlegm; hawthorn has the effects of promoting digestion, invigorating stomach, promoting qi circulation, removing blood stasis, removing turbidity and reducing blood fat; red rice has effects of promoting digestion and blood circulation, invigorating spleen and stomach; fennel has the effects of dispelling cold and relieving pain, and regulating qi and harmonizing stomach; ginger, rhizoma Zingiberis recens has the effects of relieving exterior syndrome and dispelling cold, warming middle energizer and relieving vomiting, resolving phlegm and relieving cough.
The beneficial effects of the invention are as follows:
the invention combines the traditional Chinese medicine theory and the modern medicine theory, solves the hyperlipidemia formed by the spleen-yang deficiency and the dampness accumulation and phlegm generation through tonifying qi and yang and strengthening spleen and drying dampness and phlegm, and simultaneously enhances the blood lipid reducing effect of the whole formula by using pollen typhae, red yeast rice and hawthorn. The components in the formula are medicinal and edible substances, and have no side effects. The formula has obvious hypolipidemic effect, can obviously reduce TC, TG, LDL-C content and obviously increase HDL-C content.
The traditional Chinese medicine composition is extracted by adopting a traditional water decoction method, and is subjected to freeze drying and concentration, the extraction process is simple, the cost is low, the final product does not contain ethanol, the effective components of the traditional Chinese medicine composition are reserved, the volume of the traditional Chinese medicine composition is reduced, the traditional Chinese medicine composition is convenient to take, and the traditional Chinese medicine composition is convenient to further prepare oral dosage forms such as granules, powder, medicinal granules, oral liquid and the like.
Detailed Description
Example 1
A medicinal and edible traditional Chinese medicine composition for reducing blood fat comprises the following raw materials in parts by weight: 9 parts of codonopsis pilosula, 9 parts of astragalus membranaceus, 9 parts of stir-fried bighead atractylodes rhizome, 6 parts of cinnamon, 6 parts of honey-fried licorice root, 12 parts of poria cocos, 12 parts of fructus amomi, 9 parts of semen mesonae, 10 parts of dried orange peel, 10 parts of pollen typhae, 10 parts of stir-fried radish seeds, 12 parts of hawthorn, 9 parts of red yeast rice, 6 parts of fennel and 10 parts of ginger.
The preparation method of the traditional Chinese medicine composition comprises the following steps:
(1) The traditional Chinese medicine composition is uniformly mixed according to the proportion, 3 times of water is added, and the mixture is soaked in cold water for 1 to 2 hours;
(2) Decocting for 40-60 min, and collecting filtrate;
(3) Lyophilizing the filtrate to obtain lyophilized powder of the hypolipidemic Chinese medicinal extract;
(4) The freeze-dried powder of the traditional Chinese medicine extract for reducing blood fat can be prepared into granules, powder, medicinal granules or oral liquid by conventional preparation technology.
Example 2
The freeze-dried powder of the traditional Chinese medicine extract prepared in the example 1 is added with water to prepare a solution for animal test, and the test method is as follows:
SPF-grade (180+ -10 g) male SD rats were randomly divided into a control group, a model group, a simvastatin group, a low dose group, a medium dose group, and a high dose group, 10 animals each, based on TC levels, after 1 week of adaptive feeding.
The control group rats are fed with common feed, the model group and the administration group rats are fed with high-fat feed (high-fat feed formula: 11.0% of lard, 8.0% of egg yolk, 1.5% of cholesterol and 79.5% of basic feed). The control group and the model group were perfused with distilled water. Simvastatin group simvastatin was infused at a dose of 2.1 mg/kg. The low dose group, the medium dose group and the high dose group are respectively filled with the Chinese medicinal composition according to 0.5g/kg, 1g/kg and 2 g/kg. The administration was 1 time per day for 8 weeks. After the rat is sacrificed, the inferior vena cava is bled, serum is separated, and the blood lipid content in the serum of the rat is measured.
Table 1 effect of compound lipid-lowering drugs on serum lipid content in rats (mean±sd, n=8) units: mmol.L -1
In comparison with the control group, # P＜0.05， ## p is less than 0.01; in comparison with the set of models, * P＜0.05， ** P＜0.01
table 1 shows that 3 groups of rats given compound lipid-lowering drugs all had significantly reduced serum TC, TG, LDL-C content (P < 0.01, P < 0.05) and significantly increased HDL-C content (P < 0.05) compared to the model group. The traditional Chinese medicine composition has the effect of regulating and controlling the content of serum lipid TC, TG, LDL-C, HDL-C, has the effect equivalent to that of simvastatin group and has a certain dose correlation, wherein the effects of TC, HDL-C and LDL-C are all superior to those of simvastatin.
Conclusion: the Chinese medicinal composition can remarkably reduce TC, TG, LDL-C content and remarkably increase HDL-C content.
The present invention and its embodiments have been described in detail, but not limited thereto, and those skilled in the art should appreciate that they can readily use the present invention without departing from the spirit and scope of the invention as defined by the appended claims.
Claims (8)
1. A medicinal and edible traditional Chinese medicine composition for reducing blood fat is characterized by comprising the following raw materials in parts by weight: 9-30 parts of codonopsis pilosula, 9-30 parts of astragalus membranaceus, 6-12 parts of stir-fried bighead atractylodes rhizome, 1-6 parts of cinnamon, 2-10 parts of honey-fried licorice root, 10-15 parts of poria cocos, 3-12 parts of fructus amomi, 3-9 parts of semen mesonae, 3-10 parts of dried orange peel, 5-10 parts of cattail pollen, 5-12 parts of stir-fried radish seeds, 9-12 parts of hawthorn, 3-9 parts of red yeast rice, 3-6 parts of fennel and 3-10 parts of ginger.
2. The medicinal and edible hypolipidemic traditional Chinese medicine composition according to claim 1 is characterized by comprising the following raw materials in parts by weight: 9-20 parts of codonopsis pilosula, 9-20 parts of astragalus membranaceus, 7-11 parts of stir-fried bighead atractylodes rhizome, 4-6 parts of cinnamon, 4-8 parts of honey-fried licorice root, 11-14 parts of poria cocos, 6-12 parts of fructus amomi, 5-9 parts of semen mesonae, 6-10 parts of dried orange peel, 6-10 parts of pollen typhae, 6-10 parts of stir-fried radish seeds, 10-12 parts of hawthorn, 6-9 parts of red yeast rice, 4-6 parts of fennel and 6-10 parts of ginger.
3. The medicinal and edible hypolipidemic traditional Chinese medicine composition according to claim 1 is characterized by comprising the following raw materials in parts by weight: 9 parts of codonopsis pilosula, 9 parts of astragalus membranaceus, 9 parts of stir-fried bighead atractylodes rhizome, 6 parts of cinnamon, 6 parts of honey-fried licorice root, 12 parts of poria cocos, 12 parts of fructus amomi, 9 parts of semen mesonae, 10 parts of dried orange peel, 10 parts of pollen typhae, 10 parts of stir-fried radish seeds, 12 parts of hawthorn, 9 parts of red yeast rice, 6 parts of fennel and 10 parts of ginger.
4. The medicinal and edible hypolipidemic traditional Chinese medicine composition according to claim 1, wherein the traditional Chinese medicine composition is in the form of granules, powder, medicinal granules or oral liquid.
5. A method for preparing a pharmaceutical-edible hypolipidemic traditional Chinese medicine composition according to any one of claims 1 to 4, characterized in that it comprises the following steps:
(1) Mixing the raw materials uniformly according to the proportion, and soaking in cold water for 1-2 hours;
(2) Decocting for 40-60 min, and collecting filtrate;
(3) Lyophilizing the filtrate to obtain Chinese medicinal composition lyophilized powder;
(4) And (3) preparing the freeze-dried powder obtained in the step (3) into granules, powder, medicinal granules or oral liquid.
6. The method according to claim 5, wherein the amount of cold water used in the step (1) is 3 times the total amount of the raw materials.
7. The method according to claim 5, wherein in the step (3), the concentration of the lyophilized liquid is 20%, the protecting agent is 10% mannitol, and the pH is 6-7; the freeze-drying process comprises the following steps: pre-freezing at-40deg.C for 3 hr, sublimation drying at-20deg.C for 14 hr, and analytical drying at 20deg.C for 10 hr.
8. Use of a pharmaceutical-edible hypolipidemic traditional Chinese medicine composition according to any one of claims 1-3 in the preparation of hypolipidemic drugs.
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| CN101085330A (en) * | 2007-06-08 | 2007-12-12 | 济南新境界企业管理咨询有限公司 | Oral administration traditional Chinese medicine composition for treating hyperlipoidemia |
| CN101480472A (en) * | 2008-01-09 | 2009-07-15 | 石河子大学 | Medicament for reducing blood pressure and regulating blood fat and production method |
| CN104782833A (en) * | 2015-03-24 | 2015-07-22 | 张建迎 | All-season health tea and preparation method thereof |
| CN105395919A (en) * | 2015-11-23 | 2016-03-16 | 黑龙江省科学院微生物研究所 | Composition containing black fungus extract and having effect of reducing blood fat and preparation method of composition |
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