CN110538295A

CN110538295A - traditional Chinese medicine composition for patients with damp-heat retention and abdominal obesity and preparation method thereof

Info

Publication number: CN110538295A
Application number: CN201910909181.2A
Authority: CN
Inventors: 万红
Original assignee: Individual
Current assignee: Individual
Priority date: 2019-09-25
Filing date: 2019-09-25
Publication date: 2019-12-06

Abstract

The invention relates to a traditional Chinese medicine composition for patients with damp-heat retention in the interior and abdominal obesity and a preparation method thereof. The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 25-35 parts of poria cocos extract, 25-35 parts of rhodiola rosea, 25-35 parts of lotus leaf, 25-35 parts of gynostemma pentaphylla, 10-20 parts of coptis chinensis, 10-20 parts of thunberg fritillary bulb, 10-20 parts of salvia miltiorrhiza, 10-20 parts of dried orange peel, 10-15 parts of rhizoma pinellinae praeparata, 5-15 parts of rhizoma zingiberis recens bamboo shavings, 5-15 parts of arisaema cum bile and 5-15 parts of fructus amomi, can pertinently remove dampness by utilizing water, clear heat and purge fire, comprehensively condition qi and blood, invigorate spleen and nourish stomach, and disperse and fade phlegm-dampness of a body, so that internal retention of damp-heat and abdominal obesity are fundamentally treated; the preparation method only needs to crush and mix the raw materials, has simple and controllable process and is beneficial to large-scale production.

Description

traditional Chinese medicine composition for patients with damp-heat retention and abdominal obesity and preparation method thereof

Technical Field

the invention belongs to the field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for patients with damp-heat retention in the interior and abdominal obesity and a preparation method thereof.

Background

Obesity refers to a condition of excess accumulation of body fat, especially triglycerides, due to a degree of significant overweight and an excessively thick fat layer. It does not mean a simple weight gain, but a state in which an excess of adipose tissues is accumulated in the body. Excessive accumulation of fat in the body due to excessive food intake or altered metabolism of the body causes excessive weight gain and causes pathological, physiological changes or latency in the human body.

Based on the traditional Chinese medicine thought, damp-heat can cause physique phlegm-dampness, and abdominal obesity is easily caused, and the traditional Chinese medicine has limited curative effect on damp-heat accumulation and abdominal obesity and still needs to be developed.

disclosure of Invention

in order to solve the problems in the prior art, the invention provides a traditional Chinese medicine composition for patients with damp-heat retention and abdominal obesity and a preparation method thereof. The traditional Chinese medicine composition can pertinently expel dampness by utilizing water, clear heat and purge fire, comprehensively regulate qi and blood, invigorate spleen and nourish stomach, and disperse phlegm-dampness of a body, so that internal dampness-heat and abdominal obesity can be fundamentally treated; the preparation method only needs to crush and mix the raw materials, has simple and controllable process and is beneficial to large-scale production.

The invention provides a traditional Chinese medicine composition for patients with damp-heat retention and abdominal obesity, which comprises the following raw materials in parts by weight: 25-35 parts of poria cocos extract, 25-35 parts of rhodiola rosea, 25-35 parts of lotus leaf, 25-35 parts of gynostemma pentaphylla, 10-20 parts of coptis chinensis, 10-20 parts of thunberg fritillary bulb, 10-20 parts of salvia miltiorrhiza, 10-20 parts of dried orange peel, 10-15 parts of rhizoma pinellinae praeparata, 5-15 parts of rhizoma zingiberis recens caulis bambusae in taeniam, 5-15 parts of arisaema cum bile and 5-15 parts of fructus amomi.

Preferably, the traditional Chinese medicine composition for patients with damp-heat retention and abdominal obesity comprises the following raw materials in parts by weight: 30 parts of poria extract, 30 parts of rhodiola rosea, 30 parts of lotus leaf, 30 parts of gynostemma pentaphylla, 15 parts of coptis chinensis, 15 parts of thunberg fritillary bulb, 15 parts of salvia miltiorrhiza, 15 parts of dried orange peel, 12 parts of rhizoma pinellinae praeparata, 10 parts of ginger bamboo shavings, 10 parts of arisaema cum bile and 10 parts of fructus amomi.

Preferably, the preparation method of the poria cocos extract comprises the following steps:

(i) Pulverizing Poria, soaking in ethanol solution, heating and reflux-extracting, and filtering to obtain primary extractive solution and primary residue;

(ii) Soaking the primary filter residue in ethyl acetate, heating, refluxing, extracting, and filtering to obtain a secondary extract and a secondary filter residue;

(iii) Mixing the primary extractive solution and the secondary extractive solution, concentrating the mixed solution, and oven drying to obtain Poria extract.

preferably, in the step (i), the concentration of the ethanol solution is 70-80 wt%, and the soaking time is 20-24 h.

Preferably, in the step (i), the heating reflux temperature is 74-76 ℃, and the heating reflux time is 3-4 h.

Preferably, in the step (ii), the time for soaking in ethyl acetate is 18-22 h.

Preferably, in the step (ii), the heating reflux temperature is 70-72 ℃, and the heating reflux time is 2-3 h.

preferably, in step (iii), the concentration is 1/4-1/3; the drying temperature is 40-50 ℃.

In another aspect of the present invention, a method for preparing a Chinese medicinal composition for patients with damp-heat retention in the interior and abdominal obesity is provided: pulverizing all the raw materials, and mixing.

Preferably, the granularity of the crushed materials is 100-150 meshes, and the rotating speed of mixing is 40-60 r/min; the uniformly mixed traditional Chinese medicine composition is further prepared into one of granules, pills or decoction.

In order to facilitate an understanding of the present invention, the materials and functions of the present invention will be further described below.

tuckahoe, poria cocos: sweet and light taste, mild in nature; the heart, lung, spleen and kidney meridians are entered; has effects in promoting diuresis, eliminating dampness, invigorating spleen, and calming heart; it can be used for treating edema, oliguria, phlegm and fluid retention, dizziness, palpitation, spleen deficiency, anorexia, loose stool, diarrhea, uneasiness, palpitation, and insomnia.

Rhodiola root: sweet and bitter taste, mild in nature; entering lung and heart meridians; has effects of invigorating qi, promoting blood circulation, dredging collaterals, and relieving asthma; can be used for treating qi deficiency, blood stasis, thoracic obstruction, cardialgia, apoplexy, hemiplegia, listlessness, and asthma.

Lotus leaf: bitter taste and mild nature; entering liver, spleen and stomach meridians; has effects in clearing summer-heat, eliminating dampness, promoting hair growth, clearing yang, cooling blood, and stopping bleeding; it can be used for treating summer heat, polydipsia, summer-heat, dampness, diarrhea, spleen deficiency, hematemesis, epistaxis, hematochezia, metrorrhagia, and metrostaxis.

Gynostemma pentaphylla: bitter taste and cold nature; entering lung, spleen and kidney meridians; has effects of relieving inflammation, removing toxic substances, relieving cough and eliminating phlegm; can be used for treating hyperlipidemia, hypertension, hyperglycemia, qi deficiency, asthenia, short breath, asthenia, vexation, insomnia, dizziness, and blurred vision.

Coptis chinensis: bitter taste and cold nature; the channels of heart, spleen, stomach, liver, gallbladder and large intestine; has effects in clearing away heat, eliminating dampness, purging pathogenic fire, and removing toxic materials; can be used for treating damp-heat distention and fullness, heart fire hyperactivity, and palpitation.

thunberg fritillary bulb: bitter taste and cold nature; entering lung and heart meridians; has effects of clearing heat, eliminating phlegm, resolving hard mass and removing toxic substance; can be used for treating cough due to wind-heat evil, lung abscess, sore throat, scrofula, skin and external diseases, and toxic swelling.

red sage root: bitter and slightly cold in taste; heart and liver meridian entered; has effects in promoting blood circulation, dispelling blood stasis, dredging channels, relieving pain, clearing away heart-fire, relieving restlessness, cooling blood, and eliminating carbuncle; can be used for treating thoracic obstruction, heart pain, abdominal pain, hypochondriac pain, abdominal mass, pain due to arthralgia, vexation, insomnia, menoxenia, dysmenorrhea, amenorrhea, and pyocutaneous disease with swelling and pain.

dried orange peel: bitter and pungent taste, warm in nature; entering lung and spleen meridians; has effects of regulating qi-flowing, invigorating spleen, eliminating dampness, and eliminating phlegm; can be used for treating abdominal distention, anorexia, emesis, diarrhea, cough, and excessive phlegm.

Rhizoma pinelliae preparata: pungent taste and warm nature; spleen, stomach and lung meridians entered; has effects of eliminating dampness and phlegm; can be used for treating cough and asthma with excessive phlegm, dizziness and palpitation due to phlegm and fluid retention, dizziness and vertigo due to wind-phlegm, and headache due to phlegm syncope.

Ginger bamboo shavings: sweet in taste and slightly cold in nature; it enters lung, stomach, heart and gallbladder meridians; has effects in clearing away heat, cooling blood, eliminating phlegm, and stopping emesis; can be used for treating dysphoria with smothery sensation, emesis, singultus, phlegm heat, cough and asthma, hematemesis, epistaxis, metrorrhagia, metrostaxis, threatened abortion, and convulsive epilepsy.

Arisaema cum bile: bitter and slightly pungent taste, cold nature; it enters lung, liver and spleen meridians; has effects in clearing away heat, eliminating phlegm, calming endogenous wind, and arresting convulsion; can be used for treating phlegm-heat cough, yellow and thick phlegm, apoplexy with phlegm stagnation, mania, and epilepsy.

Amomum fruit: pungent taste and warm nature; spleen, stomach and kidney meridians entered; has effects in eliminating dampness, stimulating appetite, warming spleen, relieving diarrhea, regulating qi-flowing, and preventing miscarriage; can be used for treating damp stagnation, abdominal distention, inappetence, deficiency-cold of spleen and stomach, emesis, diarrhea, hyperemesis gravidarum, and threatened abortion.

The compatibility relationship of the invention is obtained after long-term research of the inventor: the tuckahoe, the lotus leaf and the amomum fruit have the effects of promoting diuresis and eliminating dampness, and warming spleen and raising yang; coptis chinensis, caulis bambusae in taeniam and Arisaema cum bile, which are monarch drugs, have the effects of clearing heat and eliminating dampness, and purging intense heat and removing toxicity; the rhodiola rosea, the gynostemma pentaphylla and the salvia miltiorrhiza can tonify qi, activate blood and treat hypoqi and hypodynamia, and are used as ministerial drugs; pericarpium Citri Tangerinae and Bulbus Fritillariae Thunbergii have effects of regulating qi-flowing, invigorating spleen, resolving hard mass and removing toxic substance as adjuvant drugs; fa ban Xia is warm in nature and can moisten dryness and resolve phlegm, acting as a guiding drug.

The invention has the beneficial effects that:

1. The traditional Chinese medicine composition for the patients with the damp-heat accumulation and abdominal obesity can pertinently expel dampness by utilizing water, clear heat and purge fire, comprehensively regulate qi and blood, invigorate spleen and nourish stomach, and disperse phlegm and dampness of the body, so that the damp-heat accumulation and abdominal obesity can be fundamentally treated. The raw material components are absent, the compatibility is scientific, and the effect is obvious.

2. The treatment method of the traditional Chinese medicine composition for the patients with the damp-heat retention in the interior and the abdominal obesity only needs to crush and mix the raw materials, has simple and controllable process, and is beneficial to large-scale production.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention more apparent, the technical solutions of the present invention will be described in detail below. It is to be understood that the described embodiments are merely exemplary of the invention, and not restrictive of the full scope of the invention. All other embodiments, which can be derived by a person skilled in the art from the examples given herein without any inventive step, are within the scope of the present invention.

example 1

the embodiment provides a preparation method of a traditional Chinese medicine composition for patients with damp-heat retention and abdominal obesity, which comprises the following steps:

(I) The preparation method of the tuckahoe extract comprises the following steps:

(i) pulverizing Poria, soaking in 70 wt.% ethanol solution for 20h, heating and reflux-extracting at 74 deg.C for 3h, and filtering to obtain primary extractive solution and primary residue;

(ii) soaking the primary filter residue in ethyl acetate for 18h, then heating and refluxing at 70 ℃ for extraction for 2h, and filtering to obtain a secondary extracting solution and secondary filter residue;

(iii) Mixing the primary extractive solution and the secondary extractive solution, concentrating the mixed solution to 1/4 of original volume, and oven drying at 40 deg.C to obtain Poria extract.

(II) preparing the traditional Chinese medicine composition by the following steps: pulverizing 250g of poria cocos extract, 250g of rhodiola rosea, 250g of lotus leaf, 250g of gynostemma pentaphylla, 100g of coptis chinensis, 100g of thunberg fritillary bulb, 100g of salvia miltiorrhiza, 100g of dried orange peel, 100g of rhizoma pinellinae praeparata, 50g of ginger-processed bamboo shavings, 50g of arisaema cum bile and 50g of fructus amomi into 100-120 meshes, uniformly mixing under the condition of 40r/min, and preparing into a decoction.

Example 2

(i) Pulverizing Poria, soaking in 80 wt.% ethanol solution for 24h, heating and reflux-extracting at 76 deg.C for 4h, and filtering to obtain primary extractive solution and primary residue;

(ii) Soaking the primary filter residue in ethyl acetate for 22h, heating and refluxing at 72 deg.C for 3h, and filtering to obtain secondary extractive solution and secondary filter residue;

(iii) mixing the primary extractive solution and the secondary extractive solution, concentrating the mixed solution to 1/3 of original volume, and oven drying at 50 deg.C to obtain Poria extract.

(II) preparing the traditional Chinese medicine composition by the following steps: 350g of poria cocos extract, 350g of rhodiola rosea, 350g of lotus leaf, 350g of gynostemma pentaphylla, 200g of coptis chinensis, 200g of thunberg fritillary bulb, 200g of salvia miltiorrhiza, 200g of dried orange peel, 150g of rhizoma pinellinae praeparata, 150g of ginger bamboo shavings, 150g of arisaema cum bile and 150g of fructus amomi are crushed into 130-150 meshes, uniformly mixed under the condition of 60r/min and then prepared into pills.

Example 3

(i) Pulverizing Poria, soaking in 75 wt.% ethanol solution for 22h, heating and reflux-extracting at 75 deg.C for 3.5h, and filtering to obtain primary extractive solution and primary residue;

(ii) Soaking the primary filter residue in ethyl acetate for 20h, heating and refluxing at 71 deg.C for 2.5h, and filtering to obtain secondary extractive solution and secondary filter residue;

(iii) Mixing the primary and secondary extractive solutions, concentrating the mixed solution to 1/3, and oven drying at 45 deg.C to obtain Poria extract.

(II) preparing the traditional Chinese medicine composition by the following steps: 300g of poria cocos extract, 300g of rhodiola rosea, 300g of lotus leaf, 300g of gynostemma pentaphylla, 150g of coptis chinensis, 150g of thunberg fritillary bulb, 150g of salvia miltiorrhiza, 150g of dried orange peel, 120g of rhizoma pinellinae praeparata, 100g of ginger bamboo shavings, 100g of arisaema cum bile and 100g of fructus amomi are crushed into 120-130 meshes, uniformly mixed under the condition of 50r/min and then prepared into granules.

Comparative example 1

The comparative example provides a preparation method of a traditional Chinese medicine composition for patients with damp-heat retention in the interior and abdominal obesity, and the preparation method comprises the following steps:

(ii) Soaking the primary filter residue in 75 wt.% ethanol solution for 22h, heating and reflux-extracting at 75 deg.C for 3.5h, and filtering to obtain secondary extractive solution and secondary filter residue;

(II) preparing the Chinese medicinal composition by the same method as in example 3.

Comparative example 1 is arranged on the basis of example 3, and the difference between the comparative example 1 and the example 3 is as follows: in the process of preparing the tuckahoe extract, the tuckahoe extract is soaked and extracted twice by adopting ethanol solution in the comparative example 1; in example 3, the ethanol solution was used for soaking and extraction, and then ethyl acetate was used for soaking and extraction. It is the same as the operation.

Comparative example 2

(i) Pulverizing Poria, soaking in ethyl acetate for 20h, heating and reflux-extracting at 71 deg.C for 2.5h, and filtering to obtain primary extractive solution and primary residue;

Comparative example 2 is arranged on the basis of example 3, and the difference between the comparative example 2 and the example 3 is as follows: in the process of preparing the tuckahoe extract, the tuckahoe extract is soaked and extracted twice by adopting ethyl acetate in the comparative example 2; in example 3, the ethanol solution was used for soaking and extraction, and then ethyl acetate was used for soaking and extraction. It is the same as the operation.

The main effective components in poria cocos are pachymaran and pachymaran triterpenes, so the total content of pachymaran and pachymaran triterpenes in table 1 is shown by detecting the poria cocos extracts obtained in examples 1-3 and comparative examples 1-2.

TABLE 1 Poria extract obtained in examples 1-3 and comparative examples 1-2 contains pachymaran and Poria triterpenes

results and conclusions:

1. It can be seen from examples 1 to 3 that the ratio of pachyman to pachylon triterpene in the extract of poria obtained in example 3 is the highest, indicating that the extraction effect is the best when the extraction parameters are intermediate values.

2. on the basis of the best extraction effect of the embodiment 3, the comparative examples 1-2 are arranged, the result can be obtained, the type of the solvent used for extraction has an important influence on the extraction effect, and when the ethanol solution is firstly adopted and then the ethyl acetate is adopted for extraction, the effect is better than that of an extraction mode in which the same solvent is adopted twice.

In order to show the curative effect of the traditional Chinese medicine composition, the following typical cases are selected for illustration.

case (2):

Lie, male, 34 years old; mr. plum is fat, fat accumulation in abdomen and limbs, greasy face and hair, coarse skin pores, acne, asthenia, lethargy, sticky stool, dark tongue, yellow and thick tongue coating, and soft pulse; after the Chinese medicinal composition is taken by Mr. Li according to needs for 3 months, the weight is obviously reduced, the waist size is reduced, the subcutaneous and visceral fat contents are obviously reduced after comparison, and the traditional moderate fatty liver is weakened into mild fatty liver.

the above description is only for the specific embodiments of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art can easily conceive of the changes or substitutions within the technical scope of the present invention, and all the changes or substitutions should be covered within the scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the appended claims.

Claims

1. A traditional Chinese medicine composition for patients with damp-heat retention and abdominal obesity is characterized by comprising the following raw materials in parts by weight: 25-35 parts of poria cocos extract, 25-35 parts of rhodiola rosea, 25-35 parts of lotus leaf, 25-35 parts of gynostemma pentaphylla, 10-20 parts of coptis chinensis, 10-20 parts of thunberg fritillary bulb, 10-20 parts of salvia miltiorrhiza, 10-20 parts of dried orange peel, 10-15 parts of rhizoma pinellinae praeparata, 5-15 parts of rhizoma zingiberis recens caulis bambusae in taeniam, 5-15 parts of arisaema cum bile and 5-15 parts of fructus amomi.

2. the traditional Chinese medicine composition for the patients with damp-heat retention in the interior and abdominal obesity according to claim 1, which is characterized by comprising the following raw materials in parts by weight: 30 parts of poria extract, 30 parts of rhodiola rosea, 30 parts of lotus leaf, 30 parts of gynostemma pentaphylla, 15 parts of coptis chinensis, 15 parts of thunberg fritillary bulb, 15 parts of salvia miltiorrhiza, 15 parts of dried orange peel, 12 parts of rhizoma pinellinae praeparata, 10 parts of ginger bamboo shavings, 10 parts of arisaema cum bile and 10 parts of fructus amomi.

3. The traditional Chinese medicine composition for patients with damp-heat retention and abdominal obesity according to claim 1 or 2, wherein the preparation method of the poria cocos extract comprises the following steps:

4. The traditional Chinese medicine composition for patients with damp-heat retention and abdominal obesity according to claim 3, wherein in the step (i), the concentration of the ethanol solution is 70-80 wt%, and the soaking time is 20-24 h.

5. The traditional Chinese medicine composition for patients with damp-heat retention and abdominal obesity according to claim 3, wherein in the step (i), the temperature of heating reflux is 74-76 ℃, and the time of heating reflux is 3-4 h.

6. The traditional Chinese medicine composition for patients with damp-heat retention and abdominal obesity according to claim 3, wherein in the step (ii), the soaking time in ethyl acetate is 18-22 h.

7. The traditional Chinese medicine composition for the patients with damp-heat retention and abdominal obesity according to claim 3, wherein in the step (ii), the temperature of the heating reflux is 70-72 ℃, and the time of the heating reflux is 2-3 h.

8. the traditional Chinese medicine composition for patients with damp-heat retention and abdominal obesity according to claim 3, wherein in the step (iii), the concentration is 1/4-1/3; the drying temperature is 40-50 ℃.

9. The method for preparing a Chinese medicinal composition for the patients with damp-heat retention in the interior and abdominal obesity according to any one of claims 1 to 8, wherein the raw materials are pulverized and uniformly mixed.

10. The preparation method of the traditional Chinese medicine composition for the patients with damp-heat retention in the interior and abdominal obesity according to claim 9, wherein the particle size of the pulverized particles is 100-150 meshes, and the rotation speed of the mixing is 40-60 r/min; the uniformly mixed traditional Chinese medicine composition is further prepared into one of granules, pills or decoction.