CN113082174A - Preparation method of tiger eye perpetual green ointment - Google Patents
Preparation method of tiger eye perpetual green ointment Download PDFInfo
- Publication number
- CN113082174A CN113082174A CN202110378631.7A CN202110378631A CN113082174A CN 113082174 A CN113082174 A CN 113082174A CN 202110378631 A CN202110378631 A CN 202110378631A CN 113082174 A CN113082174 A CN 113082174A
- Authority
- CN
- China
- Prior art keywords
- star
- perpetual
- extract
- preparation
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 title claims abstract description 31
- 238000002360 preparation method Methods 0.000 title claims abstract description 26
- 239000002674 ointment Substances 0.000 title claims abstract description 19
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 47
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 28
- 241000499865 Ornithogalum Species 0.000 claims abstract description 23
- 235000016547 Ornithogalum umbellatum Nutrition 0.000 claims abstract description 23
- 239000000843 powder Substances 0.000 claims abstract description 23
- 238000002156 mixing Methods 0.000 claims abstract description 20
- 240000007232 Illicium verum Species 0.000 claims abstract description 14
- 235000008227 Illicium verum Nutrition 0.000 claims abstract description 14
- 239000002671 adjuvant Substances 0.000 claims abstract description 14
- 239000000203 mixture Substances 0.000 claims abstract description 14
- 210000000582 semen Anatomy 0.000 claims abstract description 14
- 238000001035 drying Methods 0.000 claims abstract description 13
- 239000000463 material Substances 0.000 claims abstract description 13
- 238000003756 stirring Methods 0.000 claims abstract description 13
- 238000000605 extraction Methods 0.000 claims abstract description 7
- 238000002791 soaking Methods 0.000 claims abstract description 7
- 244000303040 Glycyrrhiza glabra Species 0.000 claims description 14
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims description 14
- 235000017443 Hedysarum boreale Nutrition 0.000 claims description 14
- 235000007858 Hedysarum occidentale Nutrition 0.000 claims description 14
- 240000006079 Schisandra chinensis Species 0.000 claims description 14
- 239000001947 glycyrrhiza glabra rhizome/root Substances 0.000 claims description 14
- 244000077995 Coix lacryma jobi Species 0.000 claims description 13
- 238000000034 method Methods 0.000 claims description 13
- 235000013399 edible fruits Nutrition 0.000 claims description 12
- 238000005406 washing Methods 0.000 claims description 12
- 239000006071 cream Substances 0.000 claims description 7
- 238000004898 kneading Methods 0.000 claims description 6
- 238000001694 spray drying Methods 0.000 claims description 6
- 230000000857 drug effect Effects 0.000 abstract description 3
- 240000000654 Ornithogalum longebracteatum Species 0.000 description 8
- 235000008422 Schisandra chinensis Nutrition 0.000 description 7
- 210000004072 lung Anatomy 0.000 description 6
- 206010012735 Diarrhoea Diseases 0.000 description 5
- 210000000952 spleen Anatomy 0.000 description 5
- 206010011224 Cough Diseases 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 239000003094 microcapsule Substances 0.000 description 4
- 206010062717 Increased upper airway secretion Diseases 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 208000026435 phlegm Diseases 0.000 description 3
- YEFOAORQXAOVJQ-RZFZLAGVSA-N schisandrol a Chemical compound C1[C@H](C)[C@@](C)(O)CC2=CC(OC)=C(OC)C(OC)=C2C2=C1C=C(OC)C(OC)=C2OC YEFOAORQXAOVJQ-RZFZLAGVSA-N 0.000 description 3
- 210000002784 stomach Anatomy 0.000 description 3
- 231100000419 toxicity Toxicity 0.000 description 3
- 230000001988 toxicity Effects 0.000 description 3
- MPDGHEJMBKOTSU-YKLVYJNSSA-N 18beta-glycyrrhetic acid Chemical compound C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 206010059013 Nocturnal emission Diseases 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 206010016256 fatigue Diseases 0.000 description 2
- 201000007270 liver cancer Diseases 0.000 description 2
- 208000014018 liver neoplasm Diseases 0.000 description 2
- YEFOAORQXAOVJQ-UHFFFAOYSA-N wuweizischun A Natural products C1C(C)C(C)(O)CC2=CC(OC)=C(OC)C(OC)=C2C2=C1C=C(OC)C(OC)=C2OC YEFOAORQXAOVJQ-UHFFFAOYSA-N 0.000 description 2
- 208000004998 Abdominal Pain Diseases 0.000 description 1
- 206010000060 Abdominal distension Diseases 0.000 description 1
- 208000006820 Arthralgia Diseases 0.000 description 1
- 206010006895 Cachexia Diseases 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- 208000000059 Dyspnea Diseases 0.000 description 1
- 206010013975 Dyspnoeas Diseases 0.000 description 1
- MPDGHEJMBKOTSU-UHFFFAOYSA-N Glycyrrhetinsaeure Natural products C12C(=O)C=C3C4CC(C)(C(O)=O)CCC4(C)CCC3(C)C1(C)CCC1C2(C)CCC(O)C1(C)C MPDGHEJMBKOTSU-UHFFFAOYSA-N 0.000 description 1
- 241000202807 Glycyrrhiza Species 0.000 description 1
- 239000004378 Glycyrrhizin Substances 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 206010033557 Palpitations Diseases 0.000 description 1
- 241000282376 Panthera tigris Species 0.000 description 1
- 206010040007 Sense of oppression Diseases 0.000 description 1
- 206010042674 Swelling Diseases 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 208000019790 abdominal distention Diseases 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 208000022531 anorexia Diseases 0.000 description 1
- 230000003266 anti-allergic effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 239000010692 aromatic oil Substances 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 201000001352 cholecystitis Diseases 0.000 description 1
- 208000019902 chronic diarrheal disease Diseases 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 208000019425 cirrhosis of liver Diseases 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 206010061428 decreased appetite Diseases 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 206010013781 dry mouth Diseases 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- 201000006549 dyspepsia Diseases 0.000 description 1
- 208000026500 emaciation Diseases 0.000 description 1
- 229960003720 enoxolone Drugs 0.000 description 1
- 239000010685 fatty oil Substances 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 description 1
- -1 glycyrrhiza polysaccharide Chemical class 0.000 description 1
- 229960004949 glycyrrhizic acid Drugs 0.000 description 1
- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 description 1
- 235000019410 glycyrrhizin Nutrition 0.000 description 1
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 208000019423 liver disease Diseases 0.000 description 1
- 239000010687 lubricating oil Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000007721 medicinal effect Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 206010029410 night sweats Diseases 0.000 description 1
- 230000036565 night sweats Effects 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 229930193195 schizandrin Natural products 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 239000001648 tannin Substances 0.000 description 1
- 235000018553 tannin Nutrition 0.000 description 1
- 229920001864 tannin Polymers 0.000 description 1
- 230000035922 thirst Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000010415 tropism Effects 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/79—Schisandraceae (Schisandra family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
- A61K36/8994—Coix (Job's tears)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The application discloses a preparation method of a tiger eye perpetual green ointment, which comprises the following steps: step one, extraction: soaking the star-of-Bethlehem in water or ethanol for 2-3 h, and collecting the extract; step two, preparing auxiliary materials: making pericarpium Citri Tangerinae, radix Glycyrrhizae Preparata, Coicis semen, and fructus Schisandrae into adjuvant after micronizing; step three, mixing: drying the extract, mixing with superfine powder, adjuvant and water, and stirring to obtain mixture; step four, concentration: concentrating the mixture to obtain paste. The preparation method of the star anisetree bark extract is simple in preparation process, and the prepared star anisetree bark extract can quickly and fully release effective molecules of star anisetree bark after being taken by a patient, so that the drug effect of the star anisetree bark is improved.
Description
Technical Field
The application relates to the technical field of preparation of a tiger eye perpetual cream, in particular to a preparation method of the tiger eye perpetual cream.
Background
The star-of-Bethlehem has high medicinal value besides high ornamental value, and is commonly used for treating liver diseases, liver cancer, gallbladder inflammation and the like. In the prior art, the ornithogalum caudatum is directly prepared into granules and then is treated by being taken by patients, and the medicament has the problem that effective molecules in the ornithogalum caudatum cannot be fully released to treat focuses, so that the medicinal effect of the ornithogalum caudatum is reduced. Therefore, the application provides a preparation method of the tiger eye perpetual green ointment to solve the problem.
Disclosure of Invention
The application aims to provide a preparation method of the star-of-Bethlehem ointment, the preparation process is simple, and the prepared ointment can quickly and fully release effective molecules of star-of-Bethlehem after being taken by a patient, so that the drug effect of the star-of-Bethlehem ointment is ensured.
In order to achieve the purpose, the application provides a preparation method of the tiger eye permanent green ointment, which comprises the following steps:
step one, extraction: soaking the star-of-Bethlehem in water or ethanol for 2-3 h, and collecting the extract;
step two, preparing auxiliary materials: making pericarpium Citri Tangerinae, radix Glycyrrhizae Preparata, Coicis semen, and fructus Schisandrae into adjuvant after micronizing;
step three, mixing: drying the extract, mixing with superfine powder, adjuvant and water, and stirring to obtain mixture;
step four, concentration: concentrating the mixture to obtain paste.
Preferably, the first step specifically includes:
s1, washing the star-of-Bethlehem with clear water and then drying the star-of-Bethlehem;
s2, kneading the aired tiger eye perpetual green sky for 8-15 min, and then putting the tiger eye perpetual green sky into a pressurizing barrel to be pressurized and stand for 10-25 min;
s3, adding water or ethanol into a pressurizing barrel, pressurizing and standing for 0.5-1.5 h, and collecting the extract at the temperature of 10-60 ℃.
3. The preparation method of the star anisetree bark ointment as claimed in claim 2, wherein the mass ratio of the star anisetree bark to water is 15-35: 28-50 or the mass ratio of the star anisetree bark to ethanol is 15-35: 12-25.
Preferably, the second step specifically comprises:
t1, washing pericarpium Citri Reticulatae, radix Glycyrrhizae Preparata, semen Coicis, and fructus Schisandrae chinensis with clear water, and lyophilizing;
t2, processing the dried orange peel, the honey-fried licorice root, the coix seed and the Chinese magnoliavine fruit into superfine powder.
Preferably, the mass ratio of the dried orange peel, the honey-fried licorice root, the coix seed and the schisandra fruit is 3-6: 12-15: 8-12: 3-5.
Preferably, the third step specifically comprises:
d1, performing spray drying treatment on the extract;
d2, performing superfine powder treatment on the dried extract;
d3, putting the treated extract, the auxiliary materials and water into a stirring reaction kettle according to the mass ratio of 15-35: 8-10: 12-15, and uniformly mixing.
Preferably, the water content of the paste prepared in the fourth step is 5-12%.
Preferably, the step four further comprises the step of microencapsulating the prepared paste.
Has the advantages that:
the preparation method of the star anisetree bark ointment is simple in preparation process, the prepared star anisetree bark ointment can be rapidly decomposed in vivo after being taken by a patient, various molecules in the star anisetree bark can be fully released, and therefore effective molecules aiming at focuses can be absorbed by the human body and then the focuses can be treated, and the star anisetree bark ointment has good drug effect.
Drawings
In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present application, and other drawings can be obtained by those skilled in the art without creative efforts.
FIG. 1 is a flow chart of the preparation method of the star-of-Bethlehem ointment in the examples.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Please refer to FIG. 1
Example 1: a preparation method of a tiger eye perpetual green ointment comprises the following steps:
step one, extraction: soaking Ornithogalum caudatum ait in water for 2 hr, and collecting the extract. The method specifically comprises the following steps:
s1, washing the star-of-Bethlehem with clear water and then drying the star-of-Bethlehem;
s2, kneading the aired tiger eye perpetual green sky for 8min, putting the kneaded tiger eye perpetual green sky into a pressurizing barrel, pressurizing and standing for 10 min;
s3, adding water or ethanol into a pressurized barrel, wherein the mass ratio of the star of tiger eye to the water is 15:28, pressurizing and standing for 0.5h, and collecting the extract at the temperature of 20 ℃.
Step two, preparing auxiliary materials: processing pericarpium Citri Tangerinae, radix Glycyrrhizae Preparata, Coicis semen, and fructus Schisandrae into superfine powder, and making into adjuvant. The method specifically comprises the following steps:
t1, washing pericarpium Citri Reticulatae, radix Glycyrrhizae Preparata, semen Coicis, and fructus Schisandrae chinensis with clear water, and lyophilizing; the mass ratio of the dried orange peel, the honey-fried licorice root, the coix seed and the schisandra fruit is 3:12:8: 3;
t2, processing the dried orange peel, the honey-fried licorice root, the coix seed and the Chinese magnoliavine fruit into superfine powder.
Step three, mixing: drying the extract, mixing with superfine powder, adjuvant and water, and stirring to obtain mixture. The method specifically comprises the following steps:
d1, performing spray drying treatment on the extract;
d2, performing superfine powder treatment on the dried extract;
d3, putting the treated extract, the auxiliary materials and water into a stirring reaction kettle according to the mass ratio of 15:8:12, and uniformly mixing.
Step four, concentration: concentrating the mixture to obtain paste. And step four, the water content of the paste prepared in the step four is 8%, and the prepared paste is subjected to micro-capsule treatment.
Example 2: a preparation method of a tiger eye perpetual green ointment comprises the following steps:
step one, extraction: soaking Ornithogalum caudatum ait in ethanol for 2 hr, and collecting the extract. The method specifically comprises the following steps:
s1, washing the star-of-Bethlehem with clear water and then drying the star-of-Bethlehem;
s2, kneading the aired tiger eye perpetual green sky for 8min, putting the kneaded tiger eye perpetual green sky into a pressurizing barrel, pressurizing and standing for 10 min;
s3, adding water or ethanol into the pressurized barrel, wherein the mass part ratio of the ornithogalum caudatum to the ethanol is 15: 12. Standing under pressure for 0.5 hr, and collecting extract at 20 deg.C.
Step two, preparing auxiliary materials: processing pericarpium Citri Tangerinae, radix Glycyrrhizae Preparata, Coicis semen, and fructus Schisandrae into superfine powder, and making into adjuvant. The method specifically comprises the following steps:
t1, washing pericarpium Citri Reticulatae, radix Glycyrrhizae Preparata, semen Coicis, and fructus Schisandrae chinensis with clear water, and lyophilizing; the mass ratio of the dried orange peel, the honey-fried licorice root, the coix seed and the schisandra fruit is 3:12:8: 3;
t2, processing the dried orange peel, the honey-fried licorice root, the coix seed and the Chinese magnoliavine fruit into superfine powder.
Step three, mixing: drying the extract, mixing with superfine powder, adjuvant and water, and stirring to obtain mixture. The method specifically comprises the following steps:
d1, performing spray drying treatment on the extract;
d2, performing superfine powder treatment on the dried extract;
d3, putting the treated extract, the auxiliary materials and water into a stirring reaction kettle according to the mass ratio of 15:8:12, and uniformly mixing.
Step four, concentration: concentrating the mixture to obtain paste. And step four, the water content of the paste prepared in the step four is 8%, and the prepared paste is subjected to micro-capsule treatment.
Example 3: a preparation method of a tiger eye perpetual green ointment comprises the following steps:
step one, extraction: soaking Ornithogalum caudatum ait in water for 2.5 hr, and collecting the extract. The method specifically comprises the following steps:
s1, washing the star-of-Bethlehem with clear water and then drying the star-of-Bethlehem;
s2, kneading the aired tiger eye perpetual green air for 10min, putting the kneaded tiger eye perpetual green air into a pressurizing barrel, pressurizing and standing for 15 min;
s3, adding water or ethanol into a pressurized barrel, wherein the mass ratio of the star of tiger eye to the water is 20:35, pressurizing and standing for 0.8h, and collecting the extract at the temperature of 20 ℃.
Step two, preparing auxiliary materials: processing pericarpium Citri Tangerinae, radix Glycyrrhizae Preparata, Coicis semen, and fructus Schisandrae into superfine powder, and making into adjuvant. The method specifically comprises the following steps:
t1, washing pericarpium Citri Reticulatae, radix Glycyrrhizae Preparata, semen Coicis, and fructus Schisandrae chinensis with clear water, and lyophilizing; the mass ratio of the dried orange peel, the honey-fried licorice root, the coix seed and the schisandra chinensis is 6:15:12: 5;
t2, processing the dried orange peel, the honey-fried licorice root, the coix seed and the Chinese magnoliavine fruit into superfine powder.
Step three, mixing: drying the extract, mixing with superfine powder, adjuvant and water, and stirring to obtain mixture. The method specifically comprises the following steps:
d1, performing spray drying treatment on the extract;
d2, performing superfine powder treatment on the dried extract;
d3, putting the treated extract, the auxiliary materials and water into a stirring reaction kettle according to the mass ratio of 30:10:13, and uniformly mixing.
Step four, concentration: concentrating the mixture to obtain paste. And step four, the water content of the paste prepared in the step four is 10%, and the prepared paste is subjected to micro-capsule treatment.
Example 4: a preparation method of a tiger eye perpetual green ointment comprises the following steps:
step one, extraction: soaking Ornithogalum caudatum ait in water for 3 hr, and collecting the extract. The method specifically comprises the following steps:
s1, washing the star-of-Bethlehem with clear water and then drying the star-of-Bethlehem;
s2, kneading the aired tiger eye perpetual green sky for 15min, putting the kneaded tiger eye perpetual green sky into a pressurizing barrel, pressurizing and standing for 25 min;
s3, adding water or ethanol into the pressurized barrel, wherein the mass part ratio of the star-of-Bethlehem to the water is 35:50, and the mass part ratio of the star-of-Bethlehem to the ethanol is 35: 25. Standing under pressure for 1.5 hr, collecting extract, and keeping temperature at 50 deg.C.
Step two, preparing auxiliary materials: processing pericarpium Citri Tangerinae, radix Glycyrrhizae Preparata, Coicis semen, and fructus Schisandrae into superfine powder, and making into adjuvant. The method specifically comprises the following steps:
t1, washing pericarpium Citri Reticulatae, radix Glycyrrhizae Preparata, semen Coicis, and fructus Schisandrae chinensis with clear water, and lyophilizing; the mass ratio of the dried orange peel, the honey-fried licorice root, the coix seed and the schisandra chinensis is 6:15:12: 5;
t2, processing the dried orange peel, the honey-fried licorice root, the coix seed and the Chinese magnoliavine fruit into superfine powder.
Step three, mixing: drying the extract, mixing with superfine powder, adjuvant and water, and stirring to obtain mixture. The method specifically comprises the following steps:
d1, performing spray drying treatment on the extract;
d2, performing superfine powder treatment on the dried extract;
d3, putting the treated extract, the auxiliary materials and water into a stirring reaction kettle according to the mass ratio of 35:10:15, and uniformly mixing.
Step four, concentration: concentrating the mixture to obtain paste. And step four, the water content of the paste prepared in the step four is 10%, and the prepared paste is subjected to micro-capsule treatment.
The pharmacology of the above drugs is illustrated:
star of tiger eyes: the star-of-Bethlehem has the functions of clearing heat, removing toxicity, resolving hard mass and dissipating stagnation, is used for treating sore by being smeared on an affected part by folk, can treat innominate toxic swelling, hepatitis, liver cirrhosis, liver cancer and the like by being orally taken, and has good treatment effect.
Dried orange peel is characterized by nature and taste: warm in nature, pungent and bitter in flavor; meridian tropism: entering spleen, stomach and lung meridians; the main treatment effects are as follows: regulate qi-flowing for strengthening spleen, regulate middle energizer, dry dampness and resolve phlegm. It can be used for treating abdominal distention, pain, and dyspepsia due to qi stagnation of spleen and stomach. Chest oppression, abdominal distension, poor appetite and loose stool due to damp-turbidity obstruction. Cough and dyspnea due to phlegm-dampness obstructing the lung. Can be used for treating fullness in chest and abdomen, anorexia, vomiting, diarrhea, cough, and excessive phlegm.
Honey-fried licorice root: contains glycyrrhizin, glycyrrhetinic acid, and glycyrrhiza polysaccharide, and has antiinflammatory, antiallergic, immunity regulating, antitumor, and analgesic effects. Therefore, the main effects of honey-fried licorice root are to harmonize the middle warmer, relieve urgency, moisten lung, remove toxicity, and harmonize the other drugs. It is commonly indicated for weakness of spleen and stomach, lassitude, palpitation and intermittent pulse, and can relieve subsidiary toxicity.
Coix seed: to invigorate the spleen, remove dampness, remove arthralgia and check diarrhea. The Coicis semen can be used for treating edema, loempe, and dysuresia.
Schisandra chinensis: the fruit of Schisandra chinensis contains schizandrin (Schisandrin C23H3206), vitamin C, resin, tannin and a small amount of saccharide. Has the effects of astringing lung, relieving cough, nourishing, arresting seminal emission, relieving diarrhea and arresting sweating. Aromatic oil can be extracted from folium Schisandrae chinensis and fruit. The kernel contains fatty oil, and the oil can be used as industrial raw material and lubricating oil. The stalk bark fiber is flexible and can be used as a rope. The functions are mainly used for astringing lung, nourishing kidney, promoting the production of body fluid, absorbing sweat and controlling nocturnal emission. It is used to treat lung deficiency, asthma, cough, dry mouth, thirst, spontaneous perspiration, night sweat, fatigue, emaciation, nocturnal emission, chronic diarrhea, and chronic dysentery.
Finally, it should be noted that: although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that modifications may be made to the embodiments or portions thereof without departing from the spirit and scope of the invention.
Claims (8)
1. The preparation method of the tiger eye perpetual green ointment is characterized by comprising the following steps of:
step one, extraction: soaking the star-of-Bethlehem in water or ethanol for 2-3 h, and collecting the extract;
step two, preparing auxiliary materials: making pericarpium Citri Tangerinae, radix Glycyrrhizae Preparata, Coicis semen, and fructus Schisandrae into adjuvant after micronizing;
step three, mixing: drying the extract, mixing with superfine powder, adjuvant and water, and stirring to obtain mixture;
step four, concentration: concentrating the mixture to obtain paste.
2. The preparation method of the tiger eye perpetual green cream as claimed in claim 1, wherein the first step specifically comprises:
s1, washing the star-of-Bethlehem with clear water and then drying the star-of-Bethlehem;
s2, kneading the aired tiger eye perpetual green sky for 8-15 min, and then putting the tiger eye perpetual green sky into a pressurizing barrel to be pressurized and stand for 10-25 min;
s3, adding water or ethanol into a pressurizing barrel, pressurizing and standing for 0.5-1.5 h, and collecting the extract at the temperature of 10-60 ℃.
3. The preparation method of the star anisetree bark ointment as claimed in claim 2, wherein the mass ratio of the star anisetree bark to water is 15-35: 28-50 or the mass ratio of the star anisetree bark to ethanol is 15-35: 12-25.
4. The preparation method of the tiger eye perpetual green cream as claimed in claim 1, wherein the second step specifically comprises:
t1, washing pericarpium Citri Reticulatae, radix Glycyrrhizae Preparata, semen Coicis, and fructus Schisandrae chinensis with clear water, and lyophilizing;
t2, processing the dried orange peel, the honey-fried licorice root, the coix seed and the Chinese magnoliavine fruit into superfine powder.
5. The preparation method of the Huoyanwannian Qinggao according to claim 4, wherein the mass ratio of the dried orange peel, the honey-fried licorice root, the coix seed and the Chinese magnoliavine fruit is 3-6: 12-15: 8-12: 3-5.
6. The preparation method of the tiger eye perpetual green cream as claimed in claim 1, wherein the third step specifically comprises:
d1, performing spray drying treatment on the extract;
d2, performing superfine powder treatment on the dried extract;
d3, putting the treated extract, the auxiliary materials and water into a stirring reaction kettle according to the mass ratio of 15-35: 8-10: 12-15, and uniformly mixing.
7. The preparation method of the tiger eye perpetual cream as claimed in claim 1, wherein the moisture content of the cream prepared in the fourth step is 5-12%.
8. The method for preparing tiger eye perpetual green paste according to claim 1 or 7, wherein the step four further comprises microencapsulating the prepared paste.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202110378631.7A CN113082174A (en) | 2021-04-08 | 2021-04-08 | Preparation method of tiger eye perpetual green ointment |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202110378631.7A CN113082174A (en) | 2021-04-08 | 2021-04-08 | Preparation method of tiger eye perpetual green ointment |
Publications (1)
Publication Number | Publication Date |
---|---|
CN113082174A true CN113082174A (en) | 2021-07-09 |
Family
ID=76675577
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202110378631.7A Pending CN113082174A (en) | 2021-04-08 | 2021-04-08 | Preparation method of tiger eye perpetual green ointment |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN113082174A (en) |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1085439A (en) * | 1993-05-19 | 1994-04-20 | 韩忠旭 | A kind of anticancer herbal drug |
CN101773625A (en) * | 2010-03-03 | 2010-07-14 | 南京中医药大学 | Anticancerogen, preparation method and application thereof |
CN102614353A (en) * | 2012-02-13 | 2012-08-01 | 林树芳 | Saponin extraction process by using star-of-bethlehem ultrafiltration separation method |
CN111096382A (en) * | 2019-12-13 | 2020-05-05 | 邱淑琴 | Formula and preparation method of substitutional tea containing ornithogalum caudatum |
-
2021
- 2021-04-08 CN CN202110378631.7A patent/CN113082174A/en active Pending
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1085439A (en) * | 1993-05-19 | 1994-04-20 | 韩忠旭 | A kind of anticancer herbal drug |
CN101773625A (en) * | 2010-03-03 | 2010-07-14 | 南京中医药大学 | Anticancerogen, preparation method and application thereof |
CN102614353A (en) * | 2012-02-13 | 2012-08-01 | 林树芳 | Saponin extraction process by using star-of-bethlehem ultrafiltration separation method |
CN111096382A (en) * | 2019-12-13 | 2020-05-05 | 邱淑琴 | Formula and preparation method of substitutional tea containing ornithogalum caudatum |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN107029146B (en) | Traditional Chinese medicine composition for clearing lung, eliminating phlegm, tonifying qi, invigorating spleen and nourishing lung and preparation method thereof | |
CN104799048A (en) | Feed capable of improving Truogx sinensis disease resistance, and preparation method thereof | |
CN106343343A (en) | Lithocarpus polystachyus (DC.) Rehd tartarian buckwheat composition for reducing three-high and application thereof | |
KR20090127970A (en) | Uncooked food pill and its manufacturing process | |
CN104001045A (en) | Drug for treating dog pneumonia and preparation method thereof | |
CN103784918A (en) | Medicine composition for treating regurgitation-induced quidding of equus animals | |
CN104873926A (en) | Traditional Chinese medicine preparation for treating diarrhea as well as preparation method and application of traditional Chinese medicine preparation | |
CN113082174A (en) | Preparation method of tiger eye perpetual green ointment | |
CN108057115A (en) | A kind of composition for treating inflammation of upper respiratory tract infection and preparation method thereof | |
CN107823293A (en) | Treat Yao nationality medicine external pulvis of canker sore and preparation method thereof | |
CN104799007A (en) | Chinese herbal medicine additive for enhancing disease resistance of Truogx sinensis and preparation method thereof | |
CN104547701A (en) | Compound preparation for treatment of myocarditis and preparation method thereof | |
CN110538295A (en) | traditional Chinese medicine composition for patients with damp-heat retention and abdominal obesity and preparation method thereof | |
CN109276687A (en) | A kind of inrigorating qi and promoting blood circulation liquid medicine and preparation method thereof | |
CN105596999A (en) | Traditional Chinese medicine preparation for effectively treating hypertension | |
CN108524651B (en) | Traditional Chinese medicine composition for treating tracheitis | |
CN105770844A (en) | Medicine for treating gastric and duodenal ulcers and preparation method thereof | |
CN106177470A (en) | Alleviate the Chinese medicine oral liquid of student's eyestrain | |
CN113101271A (en) | Tiger eye rohdea japonica granules and compound preparation technology thereof | |
CN111588813A (en) | Traditional Chinese medicine formula for treating intractable hiccup and preparation method thereof | |
CN118767069A (en) | Traditional Chinese medicine composition for treating functional abdominal pain of children, preparation method and application thereof | |
CN104707003B (en) | The Chinese medicinal capsule for the treatment of hypertension, hyperlipidemia | |
CN117159675A (en) | Traditional Chinese medicine composition for relieving cough and reducing sputum | |
CN111617228A (en) | Traditional Chinese medicine for treating gallstones, preparation method and application thereof | |
CN111643653A (en) | Traditional Chinese medicine for treating kidney stone and gall-stone, preparation method and application thereof |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
RJ01 | Rejection of invention patent application after publication | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20210709 |