CN113082174A - Preparation method of tiger eye perpetual green ointment - Google Patents

Preparation method of tiger eye perpetual green ointment Download PDF

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CN113082174A
CN113082174A CN202110378631.7A CN202110378631A CN113082174A CN 113082174 A CN113082174 A CN 113082174A CN 202110378631 A CN202110378631 A CN 202110378631A CN 113082174 A CN113082174 A CN 113082174A
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邱淑琴
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction

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Abstract

The application discloses a preparation method of a tiger eye perpetual green ointment, which comprises the following steps: step one, extraction: soaking the star-of-Bethlehem in water or ethanol for 2-3 h, and collecting the extract; step two, preparing auxiliary materials: making pericarpium Citri Tangerinae, radix Glycyrrhizae Preparata, Coicis semen, and fructus Schisandrae into adjuvant after micronizing; step three, mixing: drying the extract, mixing with superfine powder, adjuvant and water, and stirring to obtain mixture; step four, concentration: concentrating the mixture to obtain paste. The preparation method of the star anisetree bark extract is simple in preparation process, and the prepared star anisetree bark extract can quickly and fully release effective molecules of star anisetree bark after being taken by a patient, so that the drug effect of the star anisetree bark is improved.

Description

Preparation method of tiger eye perpetual green ointment
Technical Field
The application relates to the technical field of preparation of a tiger eye perpetual cream, in particular to a preparation method of the tiger eye perpetual cream.
Background
The star-of-Bethlehem has high medicinal value besides high ornamental value, and is commonly used for treating liver diseases, liver cancer, gallbladder inflammation and the like. In the prior art, the ornithogalum caudatum is directly prepared into granules and then is treated by being taken by patients, and the medicament has the problem that effective molecules in the ornithogalum caudatum cannot be fully released to treat focuses, so that the medicinal effect of the ornithogalum caudatum is reduced. Therefore, the application provides a preparation method of the tiger eye perpetual green ointment to solve the problem.
Disclosure of Invention
The application aims to provide a preparation method of the star-of-Bethlehem ointment, the preparation process is simple, and the prepared ointment can quickly and fully release effective molecules of star-of-Bethlehem after being taken by a patient, so that the drug effect of the star-of-Bethlehem ointment is ensured.
In order to achieve the purpose, the application provides a preparation method of the tiger eye permanent green ointment, which comprises the following steps:
step one, extraction: soaking the star-of-Bethlehem in water or ethanol for 2-3 h, and collecting the extract;
step two, preparing auxiliary materials: making pericarpium Citri Tangerinae, radix Glycyrrhizae Preparata, Coicis semen, and fructus Schisandrae into adjuvant after micronizing;
step three, mixing: drying the extract, mixing with superfine powder, adjuvant and water, and stirring to obtain mixture;
step four, concentration: concentrating the mixture to obtain paste.
Preferably, the first step specifically includes:
s1, washing the star-of-Bethlehem with clear water and then drying the star-of-Bethlehem;
s2, kneading the aired tiger eye perpetual green sky for 8-15 min, and then putting the tiger eye perpetual green sky into a pressurizing barrel to be pressurized and stand for 10-25 min;
s3, adding water or ethanol into a pressurizing barrel, pressurizing and standing for 0.5-1.5 h, and collecting the extract at the temperature of 10-60 ℃.
3. The preparation method of the star anisetree bark ointment as claimed in claim 2, wherein the mass ratio of the star anisetree bark to water is 15-35: 28-50 or the mass ratio of the star anisetree bark to ethanol is 15-35: 12-25.
Preferably, the second step specifically comprises:
t1, washing pericarpium Citri Reticulatae, radix Glycyrrhizae Preparata, semen Coicis, and fructus Schisandrae chinensis with clear water, and lyophilizing;
t2, processing the dried orange peel, the honey-fried licorice root, the coix seed and the Chinese magnoliavine fruit into superfine powder.
Preferably, the mass ratio of the dried orange peel, the honey-fried licorice root, the coix seed and the schisandra fruit is 3-6: 12-15: 8-12: 3-5.
Preferably, the third step specifically comprises:
d1, performing spray drying treatment on the extract;
d2, performing superfine powder treatment on the dried extract;
d3, putting the treated extract, the auxiliary materials and water into a stirring reaction kettle according to the mass ratio of 15-35: 8-10: 12-15, and uniformly mixing.
Preferably, the water content of the paste prepared in the fourth step is 5-12%.
Preferably, the step four further comprises the step of microencapsulating the prepared paste.
Has the advantages that:
the preparation method of the star anisetree bark ointment is simple in preparation process, the prepared star anisetree bark ointment can be rapidly decomposed in vivo after being taken by a patient, various molecules in the star anisetree bark can be fully released, and therefore effective molecules aiming at focuses can be absorbed by the human body and then the focuses can be treated, and the star anisetree bark ointment has good drug effect.
Drawings
In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present application, and other drawings can be obtained by those skilled in the art without creative efforts.
FIG. 1 is a flow chart of the preparation method of the star-of-Bethlehem ointment in the examples.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Please refer to FIG. 1
Example 1: a preparation method of a tiger eye perpetual green ointment comprises the following steps:
step one, extraction: soaking Ornithogalum caudatum ait in water for 2 hr, and collecting the extract. The method specifically comprises the following steps:
s1, washing the star-of-Bethlehem with clear water and then drying the star-of-Bethlehem;
s2, kneading the aired tiger eye perpetual green sky for 8min, putting the kneaded tiger eye perpetual green sky into a pressurizing barrel, pressurizing and standing for 10 min;
s3, adding water or ethanol into a pressurized barrel, wherein the mass ratio of the star of tiger eye to the water is 15:28, pressurizing and standing for 0.5h, and collecting the extract at the temperature of 20 ℃.
Step two, preparing auxiliary materials: processing pericarpium Citri Tangerinae, radix Glycyrrhizae Preparata, Coicis semen, and fructus Schisandrae into superfine powder, and making into adjuvant. The method specifically comprises the following steps:
t1, washing pericarpium Citri Reticulatae, radix Glycyrrhizae Preparata, semen Coicis, and fructus Schisandrae chinensis with clear water, and lyophilizing; the mass ratio of the dried orange peel, the honey-fried licorice root, the coix seed and the schisandra fruit is 3:12:8: 3;
t2, processing the dried orange peel, the honey-fried licorice root, the coix seed and the Chinese magnoliavine fruit into superfine powder.
Step three, mixing: drying the extract, mixing with superfine powder, adjuvant and water, and stirring to obtain mixture. The method specifically comprises the following steps:
d1, performing spray drying treatment on the extract;
d2, performing superfine powder treatment on the dried extract;
d3, putting the treated extract, the auxiliary materials and water into a stirring reaction kettle according to the mass ratio of 15:8:12, and uniformly mixing.
Step four, concentration: concentrating the mixture to obtain paste. And step four, the water content of the paste prepared in the step four is 8%, and the prepared paste is subjected to micro-capsule treatment.
Example 2: a preparation method of a tiger eye perpetual green ointment comprises the following steps:
step one, extraction: soaking Ornithogalum caudatum ait in ethanol for 2 hr, and collecting the extract. The method specifically comprises the following steps:
s1, washing the star-of-Bethlehem with clear water and then drying the star-of-Bethlehem;
s2, kneading the aired tiger eye perpetual green sky for 8min, putting the kneaded tiger eye perpetual green sky into a pressurizing barrel, pressurizing and standing for 10 min;
s3, adding water or ethanol into the pressurized barrel, wherein the mass part ratio of the ornithogalum caudatum to the ethanol is 15: 12. Standing under pressure for 0.5 hr, and collecting extract at 20 deg.C.
Step two, preparing auxiliary materials: processing pericarpium Citri Tangerinae, radix Glycyrrhizae Preparata, Coicis semen, and fructus Schisandrae into superfine powder, and making into adjuvant. The method specifically comprises the following steps:
t1, washing pericarpium Citri Reticulatae, radix Glycyrrhizae Preparata, semen Coicis, and fructus Schisandrae chinensis with clear water, and lyophilizing; the mass ratio of the dried orange peel, the honey-fried licorice root, the coix seed and the schisandra fruit is 3:12:8: 3;
t2, processing the dried orange peel, the honey-fried licorice root, the coix seed and the Chinese magnoliavine fruit into superfine powder.
Step three, mixing: drying the extract, mixing with superfine powder, adjuvant and water, and stirring to obtain mixture. The method specifically comprises the following steps:
d1, performing spray drying treatment on the extract;
d2, performing superfine powder treatment on the dried extract;
d3, putting the treated extract, the auxiliary materials and water into a stirring reaction kettle according to the mass ratio of 15:8:12, and uniformly mixing.
Step four, concentration: concentrating the mixture to obtain paste. And step four, the water content of the paste prepared in the step four is 8%, and the prepared paste is subjected to micro-capsule treatment.
Example 3: a preparation method of a tiger eye perpetual green ointment comprises the following steps:
step one, extraction: soaking Ornithogalum caudatum ait in water for 2.5 hr, and collecting the extract. The method specifically comprises the following steps:
s1, washing the star-of-Bethlehem with clear water and then drying the star-of-Bethlehem;
s2, kneading the aired tiger eye perpetual green air for 10min, putting the kneaded tiger eye perpetual green air into a pressurizing barrel, pressurizing and standing for 15 min;
s3, adding water or ethanol into a pressurized barrel, wherein the mass ratio of the star of tiger eye to the water is 20:35, pressurizing and standing for 0.8h, and collecting the extract at the temperature of 20 ℃.
Step two, preparing auxiliary materials: processing pericarpium Citri Tangerinae, radix Glycyrrhizae Preparata, Coicis semen, and fructus Schisandrae into superfine powder, and making into adjuvant. The method specifically comprises the following steps:
t1, washing pericarpium Citri Reticulatae, radix Glycyrrhizae Preparata, semen Coicis, and fructus Schisandrae chinensis with clear water, and lyophilizing; the mass ratio of the dried orange peel, the honey-fried licorice root, the coix seed and the schisandra chinensis is 6:15:12: 5;
t2, processing the dried orange peel, the honey-fried licorice root, the coix seed and the Chinese magnoliavine fruit into superfine powder.
Step three, mixing: drying the extract, mixing with superfine powder, adjuvant and water, and stirring to obtain mixture. The method specifically comprises the following steps:
d1, performing spray drying treatment on the extract;
d2, performing superfine powder treatment on the dried extract;
d3, putting the treated extract, the auxiliary materials and water into a stirring reaction kettle according to the mass ratio of 30:10:13, and uniformly mixing.
Step four, concentration: concentrating the mixture to obtain paste. And step four, the water content of the paste prepared in the step four is 10%, and the prepared paste is subjected to micro-capsule treatment.
Example 4: a preparation method of a tiger eye perpetual green ointment comprises the following steps:
step one, extraction: soaking Ornithogalum caudatum ait in water for 3 hr, and collecting the extract. The method specifically comprises the following steps:
s1, washing the star-of-Bethlehem with clear water and then drying the star-of-Bethlehem;
s2, kneading the aired tiger eye perpetual green sky for 15min, putting the kneaded tiger eye perpetual green sky into a pressurizing barrel, pressurizing and standing for 25 min;
s3, adding water or ethanol into the pressurized barrel, wherein the mass part ratio of the star-of-Bethlehem to the water is 35:50, and the mass part ratio of the star-of-Bethlehem to the ethanol is 35: 25. Standing under pressure for 1.5 hr, collecting extract, and keeping temperature at 50 deg.C.
Step two, preparing auxiliary materials: processing pericarpium Citri Tangerinae, radix Glycyrrhizae Preparata, Coicis semen, and fructus Schisandrae into superfine powder, and making into adjuvant. The method specifically comprises the following steps:
t1, washing pericarpium Citri Reticulatae, radix Glycyrrhizae Preparata, semen Coicis, and fructus Schisandrae chinensis with clear water, and lyophilizing; the mass ratio of the dried orange peel, the honey-fried licorice root, the coix seed and the schisandra chinensis is 6:15:12: 5;
t2, processing the dried orange peel, the honey-fried licorice root, the coix seed and the Chinese magnoliavine fruit into superfine powder.
Step three, mixing: drying the extract, mixing with superfine powder, adjuvant and water, and stirring to obtain mixture. The method specifically comprises the following steps:
d1, performing spray drying treatment on the extract;
d2, performing superfine powder treatment on the dried extract;
d3, putting the treated extract, the auxiliary materials and water into a stirring reaction kettle according to the mass ratio of 35:10:15, and uniformly mixing.
Step four, concentration: concentrating the mixture to obtain paste. And step four, the water content of the paste prepared in the step four is 10%, and the prepared paste is subjected to micro-capsule treatment.
The pharmacology of the above drugs is illustrated:
star of tiger eyes: the star-of-Bethlehem has the functions of clearing heat, removing toxicity, resolving hard mass and dissipating stagnation, is used for treating sore by being smeared on an affected part by folk, can treat innominate toxic swelling, hepatitis, liver cirrhosis, liver cancer and the like by being orally taken, and has good treatment effect.
Dried orange peel is characterized by nature and taste: warm in nature, pungent and bitter in flavor; meridian tropism: entering spleen, stomach and lung meridians; the main treatment effects are as follows: regulate qi-flowing for strengthening spleen, regulate middle energizer, dry dampness and resolve phlegm. It can be used for treating abdominal distention, pain, and dyspepsia due to qi stagnation of spleen and stomach. Chest oppression, abdominal distension, poor appetite and loose stool due to damp-turbidity obstruction. Cough and dyspnea due to phlegm-dampness obstructing the lung. Can be used for treating fullness in chest and abdomen, anorexia, vomiting, diarrhea, cough, and excessive phlegm.
Honey-fried licorice root: contains glycyrrhizin, glycyrrhetinic acid, and glycyrrhiza polysaccharide, and has antiinflammatory, antiallergic, immunity regulating, antitumor, and analgesic effects. Therefore, the main effects of honey-fried licorice root are to harmonize the middle warmer, relieve urgency, moisten lung, remove toxicity, and harmonize the other drugs. It is commonly indicated for weakness of spleen and stomach, lassitude, palpitation and intermittent pulse, and can relieve subsidiary toxicity.
Coix seed: to invigorate the spleen, remove dampness, remove arthralgia and check diarrhea. The Coicis semen can be used for treating edema, loempe, and dysuresia.
Schisandra chinensis: the fruit of Schisandra chinensis contains schizandrin (Schisandrin C23H3206), vitamin C, resin, tannin and a small amount of saccharide. Has the effects of astringing lung, relieving cough, nourishing, arresting seminal emission, relieving diarrhea and arresting sweating. Aromatic oil can be extracted from folium Schisandrae chinensis and fruit. The kernel contains fatty oil, and the oil can be used as industrial raw material and lubricating oil. The stalk bark fiber is flexible and can be used as a rope. The functions are mainly used for astringing lung, nourishing kidney, promoting the production of body fluid, absorbing sweat and controlling nocturnal emission. It is used to treat lung deficiency, asthma, cough, dry mouth, thirst, spontaneous perspiration, night sweat, fatigue, emaciation, nocturnal emission, chronic diarrhea, and chronic dysentery.
Finally, it should be noted that: although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that modifications may be made to the embodiments or portions thereof without departing from the spirit and scope of the invention.

Claims (8)

1. The preparation method of the tiger eye perpetual green ointment is characterized by comprising the following steps of:
step one, extraction: soaking the star-of-Bethlehem in water or ethanol for 2-3 h, and collecting the extract;
step two, preparing auxiliary materials: making pericarpium Citri Tangerinae, radix Glycyrrhizae Preparata, Coicis semen, and fructus Schisandrae into adjuvant after micronizing;
step three, mixing: drying the extract, mixing with superfine powder, adjuvant and water, and stirring to obtain mixture;
step four, concentration: concentrating the mixture to obtain paste.
2. The preparation method of the tiger eye perpetual green cream as claimed in claim 1, wherein the first step specifically comprises:
s1, washing the star-of-Bethlehem with clear water and then drying the star-of-Bethlehem;
s2, kneading the aired tiger eye perpetual green sky for 8-15 min, and then putting the tiger eye perpetual green sky into a pressurizing barrel to be pressurized and stand for 10-25 min;
s3, adding water or ethanol into a pressurizing barrel, pressurizing and standing for 0.5-1.5 h, and collecting the extract at the temperature of 10-60 ℃.
3. The preparation method of the star anisetree bark ointment as claimed in claim 2, wherein the mass ratio of the star anisetree bark to water is 15-35: 28-50 or the mass ratio of the star anisetree bark to ethanol is 15-35: 12-25.
4. The preparation method of the tiger eye perpetual green cream as claimed in claim 1, wherein the second step specifically comprises:
t1, washing pericarpium Citri Reticulatae, radix Glycyrrhizae Preparata, semen Coicis, and fructus Schisandrae chinensis with clear water, and lyophilizing;
t2, processing the dried orange peel, the honey-fried licorice root, the coix seed and the Chinese magnoliavine fruit into superfine powder.
5. The preparation method of the Huoyanwannian Qinggao according to claim 4, wherein the mass ratio of the dried orange peel, the honey-fried licorice root, the coix seed and the Chinese magnoliavine fruit is 3-6: 12-15: 8-12: 3-5.
6. The preparation method of the tiger eye perpetual green cream as claimed in claim 1, wherein the third step specifically comprises:
d1, performing spray drying treatment on the extract;
d2, performing superfine powder treatment on the dried extract;
d3, putting the treated extract, the auxiliary materials and water into a stirring reaction kettle according to the mass ratio of 15-35: 8-10: 12-15, and uniformly mixing.
7. The preparation method of the tiger eye perpetual cream as claimed in claim 1, wherein the moisture content of the cream prepared in the fourth step is 5-12%.
8. The method for preparing tiger eye perpetual green paste according to claim 1 or 7, wherein the step four further comprises microencapsulating the prepared paste.
CN202110378631.7A 2021-04-08 2021-04-08 Preparation method of tiger eye perpetual green ointment Pending CN113082174A (en)

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CN102614353A (en) * 2012-02-13 2012-08-01 林树芳 Saponin extraction process by using star-of-bethlehem ultrafiltration separation method
CN111096382A (en) * 2019-12-13 2020-05-05 邱淑琴 Formula and preparation method of substitutional tea containing ornithogalum caudatum

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Application publication date: 20210709