CN112618637A - Traditional Chinese medicine composition for reducing blood fat and preparation method thereof - Google Patents

Traditional Chinese medicine composition for reducing blood fat and preparation method thereof Download PDF

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CN112618637A
CN112618637A CN202011577490.3A CN202011577490A CN112618637A CN 112618637 A CN112618637 A CN 112618637A CN 202011577490 A CN202011577490 A CN 202011577490A CN 112618637 A CN112618637 A CN 112618637A
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谢海青
谢君毅
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Foshan University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/535—Perilla (beefsteak plant)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/62—Nymphaeaceae (Water-lily family)
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/734—Crataegus (hawthorn)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/884—Alismataceae (Water-plantain family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps

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Abstract

The invention belongs to the technical field of traditional Chinese medicines, and discloses a traditional Chinese medicine composition for reducing blood fat and a preparation method thereof, wherein the traditional Chinese medicine composition comprises the following raw material components: the tartary buckwheat, the Chinese yam, the sealwort, the American ginseng, the radix achyranthis bidentatae and the wild artist's conk 6 natural traditional Chinese medicines are reasonably compatible, the monarch, minister, assistant and guide relations among the raw material components are clear, the synergistic effect is good, the effects of nourishing yin, tonifying spleen, tonifying qi and activating blood are ingeniously combined together, the blood sugar and the urine sugar can be stabilized in a normal range for a long time, and the blood fat is effectively reduced.

Description

Traditional Chinese medicine composition for reducing blood fat and preparation method thereof
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for reducing blood fat and a preparation method thereof.
Background
In recent years, hypertension, hyperglycemia and hyperlipidemia seriously damage the health of modern people. Along with the improvement of living standard, hypertension, hyperlipidemia and hyperglycemia are more and more common, and people suffering from obesity, hypertension and high cholesterol are troubled by bad life rhythms of long-term desk-bending work, lack of exercise and the like. Hyperlipidemia refers to the condition of abnormal fat metabolism or abnormal operation, which makes the blood lipid content in human blood exceed the normal range, and is manifested as high cholesterol and/or triglyceride or low high-density lipoprotein in blood, and is called as "dyslipidemia" in modern medicine. Hyperlipidemia is a common disease, frequently encountered disease, and especially causes the violence of cardiovascular and cerebrovascular diseases, the damage of the disease to the body is secret, gradual, progressive and systemic, and the direct damage of the disease is the acceleration of systemic atherosclerosis. The hyperlipidemia can be prevented and treated, and the long-term lipid regulation treatment can reduce the incidence and mortality of coronary heart disease, angina pectoris, myocardial infarction and cerebral apoplexy, and reduce the disability rate of hyperlipidemia.
At present, the main hypolipidemic drugs for reducing blood fat are: statins and fibrates, and the like. The common western medicine lipid-lowering drugs comprise statins and fibrates, wherein the statins can lower cholesterol and low-density lipoprotein; fibrates of lipid lowering drugs lower triglycerides. However, the western medicines all have certain side effects, for example, some patients have myalgia and myasthenia, some patients are accompanied by muscle ester kinase (CK) rise by more than 10 times, which indicates that the lipid-lowering medicines can cause muscle dissolution, and the medicines all need to be taken by the patients for a long time to have certain curative effect, so that the patients are easy to generate drug resistance, and the side effects of long-term taking are not small and varied.
Disclosure of Invention
The invention provides a traditional Chinese medicine composition for reducing blood fat and a preparation method thereof, which are used for solving one or more technical problems in the prior art and at least providing a beneficial choice or creation condition.
In order to overcome the technical problems, the technical scheme adopted by the invention is as follows:
a traditional Chinese medicine composition comprises the following raw material components: tartary buckwheat, lotus leaves, hawthorn, purple perilla, ginkgo leaves and rhizoma alismatis.
As a further improvement of the scheme, the traditional Chinese medicine composition comprises the following raw material components in parts by weight: 20-40 parts of tartary buckwheat, 5-25 parts of lotus leaves, 5-25 parts of hawthorn, 5-20 parts of purple perilla, 5-10 parts of ginkgo leaves and 8-12 parts of rhizoma alismatis.
As a further improvement of the scheme, the traditional Chinese medicine composition comprises the following raw material components in parts by weight: 25-35 parts of tartary buckwheat, 10-20 parts of lotus leaves, 10-20 parts of hawthorn, 10-15 parts of purple perilla, 6-8 parts of ginkgo leaves and 9-11 parts of rhizoma alismatis.
As a further improvement of the scheme, the dosage form of the traditional Chinese medicine composition is any one of tablets, granules, capsules, pills, oral liquid or syrup.
The preparation method of the traditional Chinese medicine composition comprises the following steps: mixing the raw material components, adding a solvent for soaking, decocting after soaking for 3 times, decocting with strong fire and slow fire, mixing decoctions, filtering, concentrating the filtrate into paste, drying, pulverizing, and sieving to obtain the traditional Chinese medicine composition.
As a further improvement of the above, the solvent is water.
As a further improvement of the proposal, an earthen pot, an enamel pot or a stainless steel pot is selected during the decoction.
As a further improvement of the scheme, the soaking time is 1-2 h.
As a further improvement of the scheme, the duration of the strong fire decoction is 20-40 min; the rest two times of decoction lasts for 30-120 min.
The traditional Chinese medicine composition disclosed by the invention is applied to preparation of a medicine for reducing blood fat.
The Chinese medicinal raw materials used in the invention have the following medicinal properties and effects:
the tartary buckwheat is bitter in nature, flat, mainly comprises bioflavonoids, multiple vitamins, 18 amino acids, crude protein, chlorophyll, selenium, zinc, magnesium, chromium, calcium and other mineral substances and trace elements, has the functions of mainly regulating qi to alleviate pain, tonifying spleen and promoting diuresis, has the functions of treating stomachache, dyspepsia, lumbocrural pain and traumatic injury, can assist in reducing blood fat, and is the best choice for staple food of patients with hyperlipidaemia.
The lotus leaf is bitter, pungent and slightly astringent, and has cold and cool nature and taste, and the lotus leaf enters heart, liver and spleen channels and has faint scent; has effects of removing summer-heat, promoting diuresis, invigorating spleen, invigorating yang, removing blood stasis, and stopping bleeding, and can be used for treating summer-heat polydipsia, headache, giddiness, edema, anorexia, abdominal distention, dysentery, leucorrhea, rectocele, hematemesis, epistaxis, hemoptysis, hematochezia, metrorrhagia, puerperal lochia, and injury blood stasis.
Haw is sour and sweet in nature and slightly warm in taste. The meridians enter spleen, stomach and liver meridians. The functional indications are as follows: promoting digestion, removing blood stasis, expelling tapeworm. It is used to treat meat stagnation, abdominal mass, phlegm retention, distention and fullness, acid regurgitation, dysentery, intestinal wind, lumbago, hernia, puerperal infantile occipital pain, and infantile indigestion. Promote digestion, invigorate stomach, promote qi circulation and dissipate blood stasis. Can be used for treating dyspepsia, flatulence, dysentery, abdominal pain, blood stasis, amenorrhea, puerperal stagnation, heart and abdominal pain, hernia pain, and hyperlipidemia.
Purple perilla is pungent in property, warm in nature and taste, and has the effects of relieving exterior syndrome, dispelling cold, regulating qi and harmonizing nutrient. It can be used for treating common cold, fever, cough, asthma, and abdominal distention. Pungent and fragrant smell, slightly pungent taste. The tea is good for patients with large leaves, purple color, no branches and stalks and strong fragrance, and is suitable for treating wind-cold affection from the exterior, dampness stagnation in the interior and the symptoms of wind-cold invasion from the exterior and wind-cold dispersion from the lung, and spleen and blood circulation.
Ginkgo leaf astringes lung, relieves asthma, promotes blood circulation to remove blood stasis, and relieves pain. Can be used for treating cough and asthma due to lung deficiency; coronary heart disease, angina pectoris, hyperlipemia and anti-coagulation.
Alisma orientale is sweet in nature and cold in nature, enters kidney and bladder meridians, induces diuresis, excrets dampness and releases heat. It is used to treat dysuria, edema, emesis, dysentery, phlegm-fluid retention, tinea pedis, gonorrhea, and hematuria.
The invention has the beneficial effects that:
the invention provides a traditional Chinese medicine composition for reducing blood fat and a preparation method thereof, 6 natural traditional Chinese medicines of tartary buckwheat, lotus leaves, hawthorn, purple perilla, ginkgo leaves and rhizoma alismatis are reasonably compatible, the raw material components have good mutual synergistic effect, the absorption of cholesterol can be effectively reduced, the blood fat metabolism is regulated, the blood fat effect is obvious, the traditional Chinese medicine composition obtained by the invention does not contain any western medicine component, the medicine for long-term administration has low toxic and side effects, the source is wide, the cost is low, the cure rate is high, the drug resistance is not easy to generate, the preparation method is simple, the application prospect is wide, and the traditional Chinese medicine composition is suitable for wide popularization.
Detailed Description
The present invention is specifically described below with reference to examples in order to facilitate understanding of the present invention by those skilled in the art. It should be particularly noted that the examples are given solely for the purpose of illustration and are not to be construed as limitations on the scope of the invention, as non-essential improvements and modifications to the invention may occur to those skilled in the art, which fall within the scope of the invention as defined by the appended claims. Meanwhile, the raw materials mentioned below are not specified in detail and are all commercially available products; the process steps or extraction methods not mentioned in detail are all process steps or extraction methods known to the person skilled in the art.
Example 1
A traditional Chinese medicine composition comprises the following raw material components in parts by weight: 25 parts of tartary buckwheat, 10 parts of lotus leaves, 10 parts of hawthorn, 10 parts of purple perilla, 6 parts of ginkgo leaves and 9 parts of rhizoma alismatis.
The preparation method of the traditional Chinese medicine composition comprises the following steps: the preparation method comprises the following steps of taking 25 parts of tartary buckwheat, 10 parts of lotus leaves, 10 parts of hawthorn, 10 parts of perilla, 6 parts of ginkgo leaves and 9 parts of rhizoma alismatis according to parts by weight, mixing, adding water which is 8 times of the total amount of raw material components, soaking for 1 hour, soaking in an earthen pot, then decocting for 3 times, decocting for 20 minutes by adopting strong fire for the first time, decocting for 20 minutes for the rest two times by adopting slow fire, filtering, adding water which is 8 times of the total amount of the raw material components into filter residues, decocting for 30 minutes for the second time, adding water which is 8 times of the total amount of the raw material components into the filter residues after filtering, decocting for 30 minutes for the 3 rd time, combining the three decoctions, filtering, concentrating the filtrate into paste, drying, crushing and sieving to obtain the finished product 1 of the traditional Chinese medicine composition for reducing blood fat.
Example 2
A traditional Chinese medicine composition comprises the following raw material components in parts by weight: 35 parts of tartary buckwheat, 20 parts of lotus leaves, 20 parts of hawthorn, 15 parts of purple perilla, 8 parts of ginkgo leaves and 11 parts of rhizoma alismatis.
The preparation method of the traditional Chinese medicine composition comprises the following steps: the preparation method comprises the following steps of taking 35 parts of tartary buckwheat, 20 parts of lotus leaves, 20 parts of hawthorn, 15 parts of perilla, 8 parts of ginkgo leaves and 11 parts of rhizoma alismatis according to parts by weight, mixing, adding water which is 10 times of the total amount of raw material components, soaking for 1 hour, soaking in an earthen pot, then decocting for 3 times, decocting for 40 minutes by adopting strong fire for the first time, decocting for 40 minutes for the rest two times by adopting slow fire, filtering, adding water which is 10 times of the total amount of the raw material components into filter residues, decocting for 120 minutes for the second time, adding water which is 10 times of the total amount of the raw material components into the filter residues after filtering, decocting for 120 minutes for the 3 times, combining the three decoctions, filtering, concentrating the filtrate into paste, drying, crushing and sieving to obtain the finished product 2 of the traditional Chinese medicine composition for reducing blood fat.
Example 3
A traditional Chinese medicine composition comprises the following raw material components in parts by weight: 30 parts of tartary buckwheat, 15 parts of lotus leaves, 15 parts of hawthorn, 12.5 parts of purple perilla, 7 parts of ginkgo leaves and 10 parts of rhizoma alismatis.
The preparation method of the traditional Chinese medicine composition comprises the following steps: taking 30 parts of tartary buckwheat, 15 parts of lotus leaves, 15 parts of hawthorn, 12.5 parts of purple perilla, 7 parts of ginkgo leaves and 10 parts of rhizoma alismatis according to parts by weight, mixing, adding water 9 times of the total amount of the raw material components, soaking for 1 hour, soaking in a casserole, then decocting for 3 times, decocting for 30 minutes by adopting strong fire for the first time, decocting for 30 minutes by adopting slow fire for the rest two times, filtering, adding water 9 times of the total amount of the raw material components into filter residues, decocting for 75 minutes for the second time, adding water 9 times of the total amount of the raw material components into the filter residues after filtering, decocting for 75 minutes for the 3 rd time, combining the three decoctions, filtering, concentrating the filtrate into paste, drying, crushing and sieving to obtain the finished product 3 of the traditional Chinese medicine composition for reducing blood fat.
Comparative example 1
A traditional Chinese medicine composition comprises the following raw material components in parts by weight: 10 parts of lotus leaf, 10 parts of hawthorn, 10 parts of perilla and 9 parts of rhizoma alismatis.
The preparation method of the traditional Chinese medicine composition comprises the following steps: taking 10 parts of lotus leaves, 10 parts of hawthorn, 10 parts of purple perilla and 9 parts of rhizoma alismatis according to parts by weight, mixing, adding water which is 9 times of the total amount of the raw material components, soaking for 1 hour, soaking in an earthen pot, then decocting for 3 times, adopting strong fire for the first time, decocting for 30min, adopting slow fire for the rest two times of decoction, adding water which is 9 times of the total amount of the raw material components into filter residue after filtering, decocting for 75min for the second time, adding water which is 9 times of the total amount of the raw material components into the filter residue after filtering, decocting for 75min for the 3 rd time, combining the three decoctions, filtering, concentrating the filtrate into paste, drying, crushing and sieving to obtain the finished product 1 of the comparative traditional Chinese medicine composition for reducing blood fat.
Comparative example 2
A traditional Chinese medicine composition comprises the following raw material components in parts by weight: 15 parts of lotus leaf, 15 parts of hawthorn, 12.5 parts of purple perilla and 10 parts of rhizoma alismatis.
The preparation method of the traditional Chinese medicine composition comprises the following steps: taking 15 parts of lotus leaves, 15 parts of hawthorn, 12.5 parts of purple perilla and 10 parts of rhizoma alismatis according to parts by weight, mixing, adding water which is 9 times of the total amount of the raw material components, soaking for 1 hour, soaking in an earthen pot, then decocting for 3 times, adopting strong fire for the first time, decocting for 30min, adopting slow fire for the rest two times, adding water which is 9 times of the total amount of the raw material components into filter residues after filtering, decocting for 75min for the second time, adding water which is 9 times of the total amount of the raw material components into the filter residues after filtering, decocting for 75min for the 3 rd time, combining the three decoctions, filtering, concentrating the filtrate into paste, drying, crushing and sieving to obtain a finished product 2 of the comparative traditional Chinese medicine composition for reducing blood fat.
Clinical trial
250 patients with hyperlipidemia were randomly selected, and the basic symptoms were: obesity, skin yellow tumor, abdominal pain, limb debilitation pain. The male and female are not limited, the male and female are randomly divided into 5 groups, 50 people are taken in each group, the first group takes the finished traditional Chinese medicine composition product 1 for reducing blood fat of the embodiment 1, the second group takes the finished traditional Chinese medicine composition product 2 for reducing blood fat of the embodiment 2, the third group takes the finished traditional Chinese medicine composition product 3 for reducing blood fat of the embodiment 3, the first group takes the finished traditional Chinese medicine composition product 1 for reducing blood fat every morning, noon and evening, the first group takes the finished traditional Chinese medicine composition product 1 for reducing blood fat, the fifth group takes the finished traditional Chinese medicine composition product 2 for reducing blood fat, after 1 month, the number of effective, effective and ineffective patients is counted, the total effective rate (%) is calculated, and clinical symptoms are observed at the same time.
The curative effect standard is as follows: the method has the following advantages: the patients with hyperlipidemia gradually improve, and the blood pressure and blood lipid in vivo recover to normal values; secondly, the method is effective: the blood pressure and the blood fat in the body are obviously reduced; ③ invalid: blood pressure and blood lipid were not improved. The results are shown in table 1 below:
TABLE 1 test Effect of the finished products obtained in examples 1 to 3 and comparative examples 1 to 2, respectively, on hyperlipidemia patients
Figure BDA0002863765310000051
As can be seen from the treatment and the record in Table 1, the performance of the first three groups of finished Chinese medicinal composition products for reducing blood fat are obviously better than the comparative examples of the fourth group, and the symptoms of the first three groups of patients are improved to a certain extent. Therefore, the raw material components have good mutual synergistic effect, the absorption of cholesterol can be reduced effectively, the blood lipid metabolism is regulated, the blood lipid effect is obvious, the obtained traditional Chinese medicine composition does not contain any western medicine component, the toxic and side effects of the medicine after long-term administration are low, the source is wide, the cost is low, the cure rate is high, the medicine resistance is not easy to generate, the preparation method is simple, the application prospect is wide, and the traditional Chinese medicine composition is suitable for wide popularization.
It will be obvious to those skilled in the art that many simple derivations or substitutions can be made without inventive effort without departing from the inventive concept. Therefore, simple modifications to the present invention by those skilled in the art according to the present disclosure should be within the scope of the present invention. The above embodiments are preferred embodiments of the present invention, and all similar processes and equivalent variations to those of the present invention should fall within the scope of the present invention.

Claims (10)

1. The traditional Chinese medicine composition is characterized by comprising the following raw material components: tartary buckwheat, lotus leaves, hawthorn, purple perilla, ginkgo leaves and rhizoma alismatis.
2. The traditional Chinese medicine composition according to claim 1, which comprises the following raw material components in parts by weight: 20-40 parts of tartary buckwheat, 5-25 parts of lotus leaves, 5-25 parts of hawthorn, 5-20 parts of purple perilla, 5-10 parts of ginkgo leaves and 8-12 parts of rhizoma alismatis.
3. The traditional Chinese medicine composition according to claim 1, which comprises the following raw material components in parts by weight: 25-35 parts of tartary buckwheat, 10-20 parts of lotus leaves, 10-20 parts of hawthorn, 10-15 parts of purple perilla, 6-8 parts of ginkgo leaves and 9-11 parts of rhizoma alismatis.
4. The traditional Chinese medicine composition as claimed in claim 1, wherein the dosage form of the traditional Chinese medicine composition is any one of tablets, granules, capsules, pills, oral liquid or syrup.
5. The method for preparing the traditional Chinese medicine composition of any one of claims 1 to 4, which is characterized by comprising the following steps: mixing the raw material components, adding a solvent for soaking, decocting after soaking for 3 times, decocting with strong fire and slow fire, mixing decoctions, filtering, concentrating the filtrate into paste, and drying to obtain the traditional Chinese medicine composition.
6. The method according to claim 5, wherein the solvent is water.
7. The method of claim 5, wherein the decoction is carried out in an earthenware pot, an enamel pot or a stainless steel pot.
8. The method of claim 5, wherein the soaking time is 1-2 hours.
9. The preparation method according to claim 5, wherein the duration of the strong fire decoction is 20-40 min; decocting with slow fire for 30-120 min.
10. Use of the Chinese medicinal composition of any one of claims 1-4 in the preparation of a medicament for reducing blood lipid.
CN202011577490.3A 2020-12-28 2020-12-28 Traditional Chinese medicine composition for reducing blood fat and preparation method thereof Withdrawn CN112618637A (en)

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Application publication date: 20210409