CN114470080A

CN114470080A - Brain-strengthening and nerve-soothing composition and preparation method thereof

Info

Publication number: CN114470080A
Application number: CN202210169726.2A
Authority: CN
Inventors: 余秉钢
Original assignee: Individual
Current assignee: Individual
Priority date: 2022-02-23
Filing date: 2022-02-23
Publication date: 2022-05-13

Abstract

The invention relates to the technical field of traditional Chinese medicines, and particularly relates to a brain-strengthening and nerve-soothing composition and a preparation method thereof. The composition for strengthening brain and soothing nerves comprises the following raw materials in parts by weight: 40-60 parts of poria with hostwood, 40-60 parts of poria cocos, 40-60 parts of red ginseng and 40-60 parts of rhizoma acori graminei. The composition has simple components and reasonable compatibility, can enhance memory, improve immunity, refresh mind, promote intelligence, tranquilize mind, promote sleep, etc., and has less side effects. The invention also provides a preparation method of the brain-strengthening and nerve-soothing composition, ethanol is used as an extraction solvent, extraction is carried out in an ultrasonic instrument, and the operation is simple.

Description

Brain-strengthening and nerve-soothing composition and preparation method thereof

Technical Field

The invention relates to the technical field of traditional Chinese medicines, and particularly relates to a brain-strengthening and nerve-soothing composition and a preparation method thereof.

Background

In modern society, the pace of life of people is faster and faster, and the pressure of life is higher and higher. People who are in fast pace for a long time are easy to have neurasthenia, such as dysphoria, lassitude, insomnia, dreaminess and other neurasthenia symptoms, and even other symptoms such as palpitation, chest distress, aching muscles and bones, weakness of limbs, soreness and leg pain and the like can be caused after the people live in the fast pace for a long time, and diseases such as hypertension, coronary heart disease, cancer and the like can be caused, so that the physical and mental health of people is seriously influenced. In addition, most people are in sub-health state, memory decline and immunity decline.

At present, most of the medicines for treating and relieving the diseases are western medicines, which treat the symptoms and do not treat the root causes, and have great side effects after long-term administration. The common biological preparation has the advantages of easy relapse of treatment effect, large drug dependence, large damage to liver, body damage and immunity reduction caused by long-term use, and generation of complications, and cannot better relieve pain of patients.

Disclosure of Invention

The invention aims to provide a brain-strengthening and nerve-soothing composition which can enhance memory, improve human immunity, refresh the mind, benefit intelligence, calm the heart, soothe the nerves, promote sleep and the like, is beneficial to strengthening the brain and soothing the nerves and has small side effect.

The invention also aims to provide a preparation method of the brain-strengthening and nerve-soothing composition, which is simple and convenient to operate.

The technical problem to be solved by the invention is realized by adopting the following technical scheme.

On one hand, the embodiment of the invention provides a brain-strengthening and nerve-soothing composition which comprises the following raw materials in parts by weight: 40-60 parts of poria, 40-60 parts of red ginseng and 40-60 parts of rhizoma acori graminei.

In another aspect, the present invention provides a method for preparing a composition for nourishing brain and tranquilizing mind, which includes: weighing Poria, Ginseng radix Rubri, and rhizoma Acori Graminei, pulverizing respectively, sieving, and mixing the obtained medicinal powders to obtain mixed medicinal powder; adding ethanol, oscillating at 25-30 deg.C for 10-12 hr, placing into an ultrasonic instrument, working for 30min-1 hr, and taking out to obtain extractive solution; filtering the extractive solution, and concentrating to obtain extract; adding excipient and binder into the obtained extract, and making into pellet.

Compared with the prior art, the embodiment of the invention has at least the following advantages or beneficial effects:

the invention provides a brain-strengthening and nerve-soothing composition, which is prepared from poria, poria cocos, red ginseng and rhizoma acori graminei, has simple components and excellent effect, can enhance memory, improve human immunity, refresh the mind, promote intelligence, calm the heart, soothe the nerves, promote sleep and the like, is beneficial to strengthening the brain and soothing the nerves, and has small side effect.

In addition, the invention also provides a preparation method of the brain-strengthening and nerve-soothing composition, which is simple to operate and high in extraction efficiency.

Detailed Description

In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.

It should be noted that the embodiments and features of the embodiments may be combined with each other without conflict. The present invention will be described in detail below with reference to specific examples.

Poria is a white part of Poria cocos sclerotium of Polyporaceae, which is naturally surrounded by pine root (i.e. Poria cocos Woodbl.). It is sweet and bland in taste and mild in nature. Has effects of calming heart, tranquilizing mind, and promoting urination. Can be used for treating palpitation due to heart deficiency, amnesia, insomnia, fright epilepsy, and dysuria. Poria has tranquilizing effect, can be combined with lignum Aquilariae Resinatum for treating unsteadiness of mind, and can be combined with Ginseng radix, radix astragali, cooked rehmanniae radix, radix Angelicae sinensis, semen Ziziphi Spinosae, and Cinnabaris for treating absentmindedness and sleeplessness. The main chemical components of the medicine are polysaccharides, pachymic acid, protein, fat, lecithin, choline, histidine and the like, and the medicine has the effects of resisting gastric ulcer, protecting liver cells, enhancing myocardial contractility, increasing heart rate, inhibiting central nervous system, reducing hyperexcitability and promoting urination. In addition, the health food also has the functions of reducing blood sugar, resisting tumors, resisting pathogenic microorganisms, promoting hematopoiesis and the like.

Poria is dried sclerotium of Poria cocos (Schw.) wolf of Polyporaceae. It is sweet and bland in flavor and mild in nature. Has effects of promoting diuresis, eliminating dampness, invigorating spleen, and calming heart. Can be used for treating edema, oliguria, phlegm and fluid retention, dizziness, palpitation, spleen deficiency, anorexia, loose stool, diarrhea, uneasiness, palpitation, and insomnia. The chemical components of the tuckahoe mainly comprise polysaccharides, triterpenes, sterols and the like, and the polysaccharides are used as one of the main components in the tuckahoe, have pharmacological activities of resisting tumors, resisting inflammation, protecting the liver, regulating the immune function and the like, and can resist depression, inhibit bacteria and reduce blood sugar to a certain extent.

Red ginseng, a plant of the genus Panax of the family Araliaceae, is warm in nature, sweet in taste and slightly bitter. Has effects of invigorating primordial qi, restoring pulse, relieving depletion, invigorating qi, and regulating blood. It is often used to treat asthenia, collapse, cold limbs, slight pulse, failure of qi to control blood, metrorrhagia and metrostaxis. The main component of Ginseng radix Rubri is triterpene saponin, and also contains volatile oil, polysaccharide, amino acids, microelements, polypeptide, etc. The triterpenoid saponin and polysaccharide of the red ginseng are main pharmacological active ingredients, can regulate nerve, cardiovascular and endocrine systems, and promote metabolism of body substances and synthesis of protein, RNA and DNA. Ginseng radix Rubri has effects of exciting central nervous system, inhibiting high level nervous activity, enhancing exciting and inhibiting process of animal, enhancing body adaptability to nonspecific stimulation, and reducing fatigue.

Acorus gramineus Soland, Acorus calamus of Araceae, mild in nature, pungent and bitter in taste. It has effects of eliminating dampness, stimulating appetite, inducing resuscitation, eliminating phlegm, refreshing mind, and improving intelligence. Can be used for treating epigastric fullness, inappetence, dysentery, coma, epilepsy, amnesia, and deafness; regulating qi, promoting blood circulation, dispelling pathogenic wind, and removing dampness; it can be used for treating epilepsy, phlegm syncope, fever, coma, amnesia, qi block, deafness, vexation, gastralgia, abdominal pain, arthralgia due to wind-cold-dampness, superficial infection, toxic swelling, and traumatic injury. Rhizoma Acori Graminei and rhizoma Zingiberis recens can be used for treating phlegm obstruction of heart orifice. Rhizoma Acori Graminei rhizome contains volatile oil, and the main component is asarone, which is a sedative effective component, and has the pharmacological effects of tranquilizing, relieving convulsion, improving memory reproduction deficiency, relieving cough, eliminating phlegm, relieving spasm, resisting bacteria, resisting arrhythmia, reducing blood lipid, inducing resuscitation, and resisting tumor. In addition, rhizoma Acori Graminei also has antifungal, antiasthmatic, antitussive, and digestive function improving effects.

In some embodiments of the present invention, the composition may further comprise the following raw materials in parts by weight: 10-20 parts of plantain seed, 8-10 parts of platycodon grandiflorum and 8-10 parts of mint.

Plantain seed, semen plantaginis, is dry mature seed of Plantago asiatica or Plantago depressa of Plantaginaceae, and has sweet taste and cold nature. Has effects of promoting diuresis, clearing heat away, improving eyesight, and eliminating phlegm. Can be used for treating dysuria, stranguria with turbid urine, leukorrhagia, hematuria, summer-heat dampness dysentery, cough with excessive phlegm, damp arthralgia, conjunctival congestion, nebula.

Radix Platycodi, plant of Campanulaceae, has effects of dispersing lung qi, relieving sore throat, eliminating phlegm, and expelling pus. Can be used for treating cough with excessive phlegm, chest distress, pharyngalgia, hoarseness, lung carbuncle, suppuration, and pyocutaneous disease with pus formation. The radix Platycodi root contains multiple saponins, wherein the saponins have effects of eliminating phlegm, resisting inflammation, reducing blood sugar, tranquilizing mind, relieving pain and relieving fever.

Mint, pungent in flavor and cool in nature. Has effects of dispelling pathogenic wind and heat, clearing head and eyes, relieving sore throat, promoting eruption, dispersing stagnated liver qi, and activating qi-flowing. Can be used for treating wind-heat common cold, headache, sore throat, food stagnation, flatulence, aphtha, toothache, scabies, urticaria, early stage of epidemic febrile disease, rubella pruritus, stagnation of qi due to depression of the liver, chest distress, and hypochondriac pain. It can be used for treating stagnation of qi due to stagnation of liver-qi by combining with bupleuri radix, radix Paeoniae alba, and radix Angelicae sinensis.

In some embodiments of the present invention, the composition may further comprise the following raw materials in parts by weight: 10-20 parts of polygala tenuifolia, 10-20 parts of eucommia ulmoides and 10-20 parts of cortex albiziae.

Polygala tenuifolia, a plant of Polygala of Polygalaceae, is perennial herb with strong root and tough and fleshy phloem. Bitter, pungent and warm in nature. Has effects in tranquilizing mind, improving intelligence, eliminating phlegm, and relieving swelling, and can be used for treating insomnia, dreaminess, amnesia, palpitation, absentmindedness, expectoration, skin sore, swelling and toxin, and breast swelling and pain caused by imbalance between heart-yang and kidney-yin.

Eucommia bark. Has the effects of tonifying liver and kidney, strengthening tendons and activating collaterals, and calming the nerves. Can be used for treating soreness of waist and back, weakness of feet and knees, dribbling urination, pruritus vulvae, vaginal discharge, threatened abortion, and hypertension.

Albizzia julibrissin dura bark is the dried bark of Albizzia julibrissin of Leguminosae, and has sweet and mild nature and taste. Has the functions of resolving depression, regulating blood, calming heart and eliminating carbuncle and swelling. It has the effects of treating uneasiness, melancholy, insomnia, pulmonary abscess, carbuncle, scrofula, and fracture and injury of tendons and bones. It is usually combined with Bai Zi ren, Dan Shen and Suan Zao ren to strengthen the actions of nourishing heart, relieving depression and tranquilizing mind for insomnia and restlessness of heart caused by emotional disorder and depression.

In some embodiments of the present invention, the following raw materials may be included in parts by weight: 50 parts of poria with hostwood, 50 parts of poria cocos, 50 parts of red ginseng, 50 parts of rhizoma acori graminei, 10 parts of semen plantaginis, 8 parts of platycodon grandiflorum, 8 parts of mint, 10 parts of polygala tenuifolia, 10 parts of eucommia ulmoides and 10 parts of cortex albiziae. In the formula, the tuckahoe, the poria with hostwood, the red ginseng and the grassleaf sweelflag rhizome can calm, resist inflammation, calm the heart, calm the nerves and enhance memory, the plantain seed, the platycodon root and the mint can dispel wind, dissipate heat, promote diuresis, relieve stranguria and remove damp-heat evil toxin in vivo, and the polygala root, the eucommia bark and the silktree albizia bark have the functions of reducing phlegm, relieving asthma, strengthening and activating collaterals and tonifying liver and kidney. The medicine has good compatibility and reasonable formula, has the effects of tonifying liver and kidney, dispelling wind and heat, moistening lung and eliminating phlegm, nourishing heart and tranquilizing mind and promoting sleep, and has higher effects of tranquilizing mind and strengthening brain.

In another aspect, the present invention provides a method for preparing a composition for nourishing brain and tranquilizing mind, comprising:

s1 pulverizing Poria, radix Ginseng Rubra, and rhizoma Acori Tatarinowii respectively, sieving, and mixing the powders to obtain mixed powder;

s2 adding ethanol, oscillating at 25-30 deg.C for 10-12h, placing into an ultrasonic instrument, working for 30min-1h, and taking out to obtain extractive solution;

s3, carrying out suction filtration and concentration on the extracting solution to obtain an extract;

s4 adding excipient and binder into the extract obtained in S3, and making into pellet.

The preparation method is simple, and the composition is made into pellet for convenient administration.

In some embodiments of the invention, the concentration of ethanol in S2 is 75-85%. When the concentration of the ethanol is 75-85%, the bacteriostatic effect is good, the growth of some fungus substances in the extraction process can be inhibited, and the leaching rate of effective components in the medicine is also high.

In some embodiments of the present invention, in S2, the ratio of the mixed powder to the solvent is 1:20-1: 30. When the ratio of the materials to the liquid is 1:20-1:30, the antibacterial effect is better.

In some embodiments of the present invention, in S2, the ultrasonic power of the ultrasonic instrument is 600-. The extraction is carried out in an ultrasonic instrument with the temperature of 37-42 ℃ and the ultrasonic power of 600-800W, so that the extraction efficiency can be increased, and the bacteriostatic effect is better.

In some embodiments of the present invention, in S4, the excipient is one or more of sucrose, honey, dextrin, starch, microcrystalline cellulose, lactose, methyl cellulose, sodium carboxymethyl cellulose, polyvinylpyrrolidone, ethyl cellulose, acrylic resin, hydroxypropyl methyl cellulose, and gelatin. The excipient is an additive in the pharmaceutical preparation except the main drug, and can also be called as an auxiliary material. The excipient has stable property, no incompatibility with the main drug, no side effect, no influence on curative effect, no deformation at normal temperature, no crack, mildew or worm damage, no harm to human body, no physiological effect, and no chemical or physical effect with the main drug.

In some embodiments of the present invention, in S4, the adhesive is one or more of polyvinylpyrrolidone, cellulose, resin, saccharide and animal glue. Adhesives are one of the most important auxiliary materials. It has adhesive properties by which various separate materials are joined together.

The features and properties of the present invention are described in further detail below with reference to examples.

Example 1

The present embodiment aims to provide a brain-strengthening and nerve-soothing composition, which comprises the following raw materials:

40g of poria with hostwood, 40g of poria cocos, 40g of red ginseng and 40g of rhizoma acori graminei.

The specific preparation method of the composition comprises the following steps:

weighing Poria, Ginseng radix Rubri, and rhizoma Acori Graminei, pulverizing respectively, sieving, and mixing the obtained medicinal powders to obtain mixed medicinal powder; adding ethanol into the mixed medicinal powder, wherein the ratio of the mixed medicinal powder to the ethanol is 1:20, oscillating for 10 hours at 25 ℃, putting the mixture into an ultrasonic instrument after oscillation, wherein the ultrasonic power is 600W, the temperature is 37 ℃, and taking out the mixture after working for 30min to obtain an extracting solution; filtering the extractive solution, and concentrating to obtain extract; adding sucrose and polyvinylpyrrolidone into the extract, and making into pellet. The weight percentages of the extract, the sucrose and the polyvinylpyrrolidone are as follows: 50%: 20%: 30 percent.

Example 2

50g of poria with hostwood, 50g of poria cocos, 50g of red ginseng and 50g of rhizoma acori graminei.

weighing Poria, Ginseng radix Rubri, and rhizoma Acori Graminei, pulverizing respectively, sieving, and mixing the obtained medicinal powders to obtain mixed medicinal powder; adding ethanol into the mixed medicinal powder, wherein the ratio of the mixed medicinal powder to the ethanol is 1: 25, oscillating for 12 hours at 26 ℃, putting the mixture into an ultrasonic instrument after oscillation, wherein the ultrasonic power is 700W, the temperature is 38 ℃, and taking out the mixture after working for 45min to obtain an extracting solution; filtering the extractive solution, and concentrating to obtain extract; adding Mel into the extract, and making into pellet. The weight percentages of the extract and the honey are as follows: 37.5%: 57.5 percent.

Example 3

60g of poria with hostwood, 60g of poria cocos, 60g of red ginseng and 60g of rhizoma acori graminei.

weighing Poria, Ginseng radix Rubri, and rhizoma Acori Graminei, pulverizing respectively, sieving, and mixing the obtained medicinal powders to obtain mixed medicinal powder; adding ethanol into the mixed medicinal powder, wherein the ratio of the mixed medicinal powder to the ethanol is 1:30, oscillating for 11 hours at the temperature of 30 ℃, putting the product into an ultrasonic instrument after oscillation, wherein the ultrasonic power is 800W, the temperature is 39 ℃, and taking out the product after 50min of work to obtain an extracting solution; filtering the extractive solution, and concentrating to obtain extract; adding dextrin and Colophonium into the extract, and making into pellet. The weight percentages of the extract, dextrin and rosin are as follows: 50%: 20%: 30 percent.

Example 4

The present embodiment aims to provide a brain-strengthening and mind-tranquilizing composition, which comprises the following raw materials:

40g of poria with hostwood, 40g of poria cocos, 40g of red ginseng, 40g of rhizoma acori graminei, 10g of semen plantaginis, 8g of platycodon grandiflorum and 8g of mint.

weighing Poria, Ginseng radix Rubri, rhizoma Acori Graminei, semen plantaginis, radix Platycodi and herba Menthae, respectively pulverizing, sieving, and mixing the obtained medicinal powders to obtain mixed medicinal powder; adding ethanol into the mixed medicinal powder, wherein the ratio of the mixed medicinal powder to the ethanol is 1: 24, oscillating for 10 hours at the temperature of 30 ℃, putting the product into an ultrasonic instrument after oscillation, wherein the ultrasonic power is 600W, the temperature is 40 ℃, and taking out the product after working for 30min to obtain an extracting solution; filtering the extractive solution, and concentrating to obtain extract; adding sucrose and polyvinylpyrrolidone into the extract, and making into pellet. The weight percentages of the extract, the sucrose and the polyvinylpyrrolidone are as follows: 50%: 20%: 30 percent.

Example 5

50g of poria with hostwood, 50g of poria cocos, 50g of red ginseng, 50g of rhizoma acori graminei, 15g of semen plantaginis, 9g of platycodon grandiflorum and 9g of mint.

weighing Poria, Ginseng radix Rubri, rhizoma Acori Graminei, semen plantaginis, radix Platycodi and herba Menthae, respectively pulverizing, sieving, and mixing the obtained medicinal powders to obtain mixed medicinal powder; adding ethanol into the mixed medicinal powder, wherein the ratio of the mixed medicinal powder to the ethanol is 1:20, oscillating for 12 hours at the temperature of 30 ℃, putting the mixture into an ultrasonic instrument after oscillation, wherein the ultrasonic power is 700W, the temperature is 41 ℃, and taking out the mixture after working for 1 hour to obtain an extracting solution; filtering the extractive solution, and concentrating to obtain extract; adding sucrose and polyvinylpyrrolidone into the extract, and making into pellet. The weight percentages of the extract, the sucrose and the polyvinylpyrrolidone are as follows: 50%: 20%: 30 percent.

Example 6

50g of poria with hostwood, 50g of poria cocos, 50g of red ginseng, 50g of rhizoma acori graminei, 20g of semen plantaginis, 10g of platycodon grandiflorum and 10g of mint.

weighing Poria, Ginseng radix Rubri, rhizoma Acori Graminei, semen plantaginis, radix Platycodi and herba Menthae, respectively pulverizing, sieving, and mixing the obtained medicinal powders to obtain mixed medicinal powder; adding ethanol into the mixed medicinal powder, wherein the ratio of the mixed medicinal powder to the ethanol is 1: 25, oscillating for 12 hours at the temperature of 30 ℃, putting the mixture into an ultrasonic instrument after oscillation, wherein the ultrasonic power is 750W, the temperature is 42 ℃, and taking out the mixture after working for 1 hour to obtain an extracting solution; filtering the extractive solution, and concentrating to obtain extract; adding sucrose and polyvinylpyrrolidone into the extract, and making into pellet. The weight percentages of the extract, the sucrose and the polyvinylpyrrolidone are as follows: 50%: 20%: 30 percent.

Example 7

40g of poria with hostwood, 40g of poria cocos, 40g of red ginseng, 40g of rhizoma acori graminei, 10g of semen plantaginis, 8g of platycodon grandiflorum, 8g of mint, 10g of polygala tenuifolia, 10g of eucommia ulmoides and 10g of cortex albiziae.

weighing Poria, Ginseng radix Rubri, rhizoma Acori Graminei, semen plantaginis, radix Platycodi, herba Menthae, cortex et radix Polygalae, Eucommiae cortex and cortex Albizziae, respectively pulverizing, sieving, and mixing the obtained medicinal powders to obtain mixed medicinal powder; adding ethanol into the mixed medicinal powder, wherein the ratio of the mixed medicinal powder to the ethanol is 1:30, oscillating for 12 hours at the temperature of 30 ℃, putting the mixture into an ultrasonic instrument after oscillation, wherein the ultrasonic power is 800W, the temperature is 38 ℃, and taking out the mixture after working for 42min to obtain an extracting solution; filtering the extractive solution, and concentrating to obtain extract; adding sucrose and polyvinylpyrrolidone into the extract, and making into pellet. The weight percentage of the extract, the sucrose and the polyvinylpyrrolidone is as follows: 50%: 20%: 30 percent.

Example 8

45g of poria with hostwood, 45g of poria cocos, 45g of red ginseng, 45g of rhizoma acori graminei, 20g of polygala tenuifolia, 20g of eucommia ulmoides and 20g of cortex albiziae.

weighing Poria, Ginseng radix Rubri, rhizoma Acori Graminei, cortex et radix Polygalae, Eucommiae cortex and cortex Albizziae, respectively pulverizing, sieving, and mixing the obtained medicinal powders to obtain mixed medicinal powder; adding ethanol into the mixed medicinal powder, wherein the ratio of the mixed medicinal powder to the ethanol is 1: 24, oscillating at 30 ℃ for 12h, putting the product into an ultrasonic instrument after oscillation, wherein the ultrasonic power is 650W, the temperature is 39 ℃, and taking out the product after 50min of work to obtain an extracting solution; filtering the extractive solution, and concentrating to obtain extract; adding sucrose and polyvinylpyrrolidone into the extract, and making into pellet. The weight percentages of the extract, the sucrose and the polyvinylpyrrolidone are as follows: 50%: 20%: 30 percent.

Example 9

60g of poria with hostwood, 60g of poria cocos, 60g of red ginseng, 60g of rhizoma acori graminei, 15g of polygala tenuifolia, 15g of eucommia ulmoides and 15g of cortex albiziae.

weighing Poria, Ginseng radix Rubri, rhizoma Acori Graminei, cortex et radix Polygalae, Eucommiae cortex and cortex Albizziae, respectively pulverizing, sieving, and mixing the obtained medicinal powders to obtain mixed medicinal powder; adding ethanol into the mixed medicinal powder, wherein the ratio of the mixed medicinal powder to the ethanol is 1: 25, oscillating for 12 hours at 30 ℃, putting the mixture into an ultrasonic instrument after oscillation, wherein the ultrasonic power is 600W, the temperature is 42 ℃, and taking out the mixture after working for 50min to obtain an extracting solution; filtering the extractive solution, and concentrating to obtain extract; adding Mel into the extract, and making into oral liquid. The weight percentages of the extract and the honey are as follows: 37.5%: 57.5 percent.

Examples of the experiments

In order to further examine the clinical curative effect of the medicine, 90 neurasthenia patients are selected for clinical trials, all patients have symptoms of dysphoria, listlessness, insomnia, dreaminess, poor appetite, weakness, hypodynamia, hypomnesis and the like caused by high working and living pressure, and the normal work and life are influenced after clinical diagnosis. Wherein the male is 42, the female is 48, the age is 20-48 years, and the average age is 30 years. The treatment group 1, the treatment group 2 and the control group are randomly divided, 30 cases are adopted in each group, and the baseline data of age, sex, weight, symptoms and the like of the two groups of people are statistically analyzed, and the difference has no statistical significance (P is more than 0.05) and is comparable.

The curative effect standard is as follows:

and (3) curing: clinical symptoms disappear, and normal work and life are not affected;

the method has the following advantages: the clinical symptoms are improved, the appetite is increased, the symptoms such as insomnia, hypodynamia, dizziness, headache and the like are improved, and the memory is increased;

and (4) invalidation: the clinical symptoms are unchanged or aggravated after the medicine is taken.

The treatment method comprises the following steps:

treatment group 1: the prepared pellet of example 1 was taken twice a day for 30 days, 3.3 + -0.2 g once.

Treatment group 2: the pellet prepared in example 6 was taken 3.3 + -0.2 g once, twice a day, and taken for 30 days.

Control group: the tablet is orally administered for tranquilizing and strengthening brain (Tonghua Miaoxiang pharmaceutical preparation, Z20026740), 1 tablet at a time, 2 times a day. The curative effect is judged after the three groups are treated for 30 days.

TABLE 1 comparison of clinical efficacy results of three groups of patients

As can be seen from table 1, the treatment group 1 has 11 cases of cure, 17 cases of effective treatment and 2 cases of ineffective treatment, and the total effective rate reaches 93%. The treatment group 2 has 10 cured cases, 16 effective cases and 4 ineffective cases, and the total effective rate is 86%. The control group has 7 cured cases, 13 effective cases and 10 ineffective cases, and the total effective rate is 66.6 percent. The effect of the treatment group is obvious because the comparison difference of the two groups has statistical significance. In addition, in the taking process, three groups of patients have no obvious adverse reaction, and the main safety indexes of blood, urine, stool routine and electrocardiogram and other detection before and after treatment have no special change.

The results show that the composition for strengthening the brain and soothing the nerves has the advantages of exact curative effect, high cure rate, side effect and convenient administration.

In summary, the embodiments of the present invention provide a composition for nourishing brain and tranquilizing mind and a preparation method thereof. The composition has effects of tranquilizing mind, relieving inflammation, calming heart, and improving memory, and has simple formula, small side effect, and also has certain effect on preventing senile dementia. Semen plantaginis, radix Platycodi and herba Menthae can also be added to dispel wind and heat, promote diuresis and relieve stranguria, and remove damp-heat and pathogenic toxin in vivo. In addition, polygala tenuifolia, eucommia ulmoides and cortex albiziae can be added into the formula to resolve phlegm, relieve asthma, activate collaterals powerfully and tonify liver and kidney. The medicine has good compatibility and reasonable formula, and has effects of invigorating liver and kidney, dispelling pathogenic wind and heat, moistening lung and eliminating phlegm, nourishing heart and tranquilizing mind, and promoting sleep, and has higher effects of tranquilizing mind and nourishing brain.

The embodiments described above are some, not all embodiments of the invention. The detailed description of the embodiments of the present invention is not intended to limit the scope of the invention as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be obtained by a person skilled in the art without inventive step based on the embodiments of the present invention, are within the scope of protection of the present invention.

Claims

1. The composition for strengthening brain and soothing nerves is characterized by comprising the following raw materials in parts by weight: 40-60 parts of poria, 40-60 parts of red ginseng and 40-60 parts of rhizoma acori graminei.

2. The composition for nourishing brain and soothing nerves according to claim 1, further comprising the following raw materials in parts by weight: 10-20 parts of semen plantaginis, 8-10 parts of platycodon grandiflorum and 8-10 parts of mint.

3. The composition for nourishing brain and soothing nerves according to claim 2, further comprising the following raw materials in parts by weight: 10-20 parts of polygala tenuifolia, 10-20 parts of eucommia ulmoides and 10-20 parts of cortex albiziae.

4. The composition for nourishing brain and soothing nerves according to claim 3, which is characterized by comprising the following raw materials in parts by weight: 50 parts of poria with hostwood, 50 parts of poria cocos, 50 parts of red ginseng, 50 parts of rhizoma acori graminei, 10 parts of semen plantaginis, 8 parts of platycodon grandiflorum, 8 parts of mint, 10 parts of polygala tenuifolia, 10 parts of eucommia ulmoides and 10 parts of cortex albiziae.

5. A method for preparing a brain-invigorating and tranquilizing composition according to any one of claims 1 to 4, comprising:

6. The method for preparing a composition for strengthening brain and tranquilizing mind according to claim 5, wherein the concentration of ethanol in S2 is 75-85%.

7. The method for preparing a composition for strengthening brain and tranquilizing mind according to claim 5, wherein in the step S2, the ratio of the mixed powder to the ethanol is 1:20-1: 30.

8. The method for preparing the composition for strengthening brain and tranquilizing mind as claimed in claim 5, wherein in S2, the ultrasonic power of the ultrasonic instrument is 600-800W, and the working temperature is 37-42 ℃.

9. The method for preparing the composition for strengthening brain and tranquilizing mind according to claim 5, wherein in the step S4, the excipient is one or more selected from sucrose, honey, dextrin, starch, microcrystalline cellulose, lactose, methyl cellulose, sodium carboxymethyl cellulose, polyvinylpyrrolidone, ethyl cellulose, acrylic resin, hydroxypropyl methyl cellulose and gelatin.

10. The method for preparing the composition for strengthening the brain and tranquilizing the mind according to claim 5, wherein in the step S4, the binder is one or more selected from polyvinylpyrrolidone, celluloses, resins, saccharides and animal glue.