CN112587613A - A composition for treating diabetes and preparation method thereof - Google Patents

A composition for treating diabetes and preparation method thereof Download PDF

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CN112587613A
CN112587613A CN202011577503.7A CN202011577503A CN112587613A CN 112587613 A CN112587613 A CN 112587613A CN 202011577503 A CN202011577503 A CN 202011577503A CN 112587613 A CN112587613 A CN 112587613A
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谢海青
谢君毅
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Foshan University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/074—Ganoderma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/894—Dioscoreaceae (Yam family)
    • A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8969—Polygonatum (Solomon's seal)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps

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  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
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Abstract

The invention belongs to the technical field of traditional Chinese medicines, and discloses a composition for treating diabetes and a preparation method thereof, wherein the composition comprises the following raw material components: the tartary buckwheat, the Chinese yam, the sealwort, the American ginseng, the radix achyranthis bidentatae and the wild tongue of the tree 6 natural traditional Chinese medicines are reasonably compatible, the monarch, minister, assistant and guide relationships among the raw material components are clear, the synergistic effect is good, the effects of nourishing yin, tonifying spleen, replenishing qi and activating blood are ingeniously combined together, the blood sugar and the urine sugar can be stabilized in a normal range for a long time, and the diabetes is effectively treated.

Description

A composition for treating diabetes and preparation method thereof
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a composition for treating diabetes and a preparation method thereof.
Background
Diabetes is a group of metabolic diseases characterized by hyperglycemia (fasting blood glucose exceeds 7.0, or blood glucose exceeds 11.1 in two hours after a meal, and diabetes can be diagnosed). Hyperglycemia is caused by a defect in insulin secretion or an impaired biological action, or both. The chronic hyperglycemia results in chronic damage and dysfunction of various tissues, particularly eyes, kidneys, heart, blood vessels and nerves. It is generally divided into two major categories, of which type 2 diabetes accounts for about 90% of the total number of diabetes, and is mainly characterized by chronic hyperglycemia; because the blood sugar of the diabetic cannot be effectively controlled within a reasonable range in time for a long time, chronic injuries, dysfunctions and complications of various organs, such as cardiovascular diseases, kidney damage, retinopathy and even blindness, are caused over time, and huge burden is brought to the diabetic and the society.
At present, the hypoglycemic drugs for treating diabetes mainly comprise: biguanide drugs, sulfonylurea drugs, thiazolidinedione drugs, glinide drugs, alpha-glycosidase inhibitors, dipeptidyl peptidase-4 (DPP-4) inhibitors. However, these drugs do not cure diabetes radically, and at the same time, various therapeutic drugs have adverse reactions: such as hypoglycemic events and weight gain (e.g., insulin and insulin secretagogues, etc.), gastrointestinal reactions (e.g., biguanide drugs, glycosidase inhibitors, GLP-1 receptor agonists, etc.), weight gain, edema, or adverse cardiac events (e.g., thiazolidinedione drugs TZDs), etc. As a result, patients have disease tolerance, so that the effect of reducing blood sugar can be effectively achieved only by taking a large amount of hypoglycemic drugs, but long-term use of insulin can cause the patients to have drug dependence, still has temporary solution and permanent solution, and the blood sugar of the patients is difficult to be effectively controlled and is easy to repeat.
Disclosure of Invention
The present invention provides a composition for treating diabetes and a preparation method thereof, which solves one or more technical problems in the prior art and provides at least one useful choice or creation condition.
In order to overcome the technical problems, the technical scheme adopted by the invention is as follows:
a composition comprises the following raw material components: tartary buckwheat, Chinese yam, rhizoma polygonati, American ginseng, radix achyranthis bidentatae and wild Ganoderma applanatum.
As a further improvement of the scheme, the composition comprises the following raw material components in parts by weight: 20-40 parts of tartary buckwheat, 20-40 parts of Chinese yam, 5-25 parts of rhizoma polygonati, 5-25 parts of American ginseng, 8-15 parts of radix achyranthis bidentatae and 5-30 parts of wild Ganoderma applanatum.
As a further improvement of the scheme, the composition comprises the following raw material components in parts by weight: 25-35 parts of tartary buckwheat, 25-35 parts of Chinese yam, 10-20 parts of rhizoma polygonati, 10-20 parts of American ginseng, 10-12 parts of radix achyranthis bidentatae and 15-20 parts of wild Ganoderma applanatum.
As a further improvement of the above scheme, the composition is in the form of any one of tablets, granules, capsules, pills, oral liquid or syrups.
The preparation method of the composition comprises the following steps: firstly, mixing the raw material components, adding a solvent for soaking, decocting after soaking for 3 times, wherein strong fire is adopted for the first time of decoction, slow fire is adopted for the other two times of decoction, the three decoctions are combined, filtering is carried out, the filtrate is concentrated into paste, and drying is carried out, thus obtaining the composition.
As a further improvement of the above, the solvent is water.
As a further improvement of the proposal, an earthen pot, an enamel pot or a stainless steel pot is selected during the decoction.
As a further improvement of the scheme, the soaking time is 1-2 h.
As a further improvement of the above scheme, the time length of the first decoction is 20-40 min; the rest two times of decoction lasts for 30-120 min.
The composition provided by the invention is applied to the preparation of medicines for treating diabetes.
The Chinese medicinal raw materials used in the invention have the following medicinal properties and effects:
the tartary buckwheat is bitter in nature, flat, mainly comprises bioflavonoids, multiple vitamins, 18 amino acids, crude protein, chlorophyll, selenium, zinc, magnesium, chromium, calcium and other mineral substances and trace elements, has the functions of mainly regulating qi to alleviate pain, tonifying spleen and promoting diuresis, has the functions of treating stomachache, dyspepsia, lumbocrural pain and traumatic injury, can assist in treating diabetes, and is the best choice for staple food of diabetics.
Huai shan is sweet and neutral. Strengthen spleen and stomach, benefit lung and kidney, tonify deficiency and save. It is indicated for poor appetite, loose stool, consumptive disease, cough and asthma, frequent micturition, leukorrhagia, and diabetes, and for spleen deficiency, poor appetite, diarrhea, loose stool, and leukorrhagia.
Rhizoma Polygonati is also named JITONGHUANGJIAO, HUANGJICAI, TUNZHUCAI, rhizoma Gymnadeniae, radix Codonopsis Lanceolatae, rhizoma Kadsurae Longipedunculatae, and radix Codonopsis Lanceolatae. Is a plant of Polygonatum, with transverse rhizome, cylindrical shape, enlarged nodule, and no stem. The medicinal plant has the functions of invigorating spleen, moistening lung and promoting fluid production. The meat is sweet in taste, tasty and refreshing in eating, the fleshy root is fat and thick, contains a large amount of starch, sugar, fat, protein, carotene, vitamins and various other nutritional ingredients, can allay hunger when eaten raw or stewed, has the function of body building, can increase the strength of human body, is full of muscles and strong in marrow, and is very beneficial to the human body. Rhizoma polygonati rhizome is shaped like sweet potato, and is often eaten as vegetable by people in mountainous areas.
American ginseng is cool in nature, sweet and slightly bitter in taste. The functions are mainly used for tonifying qi and nourishing yin, and clearing heat and promoting fluid production. Can be used for treating deficiency of qi and yin, internal heat, cough, asthma, phlegm, asthenia, fever, vexation, fatigue, diabetes, and dry mouth. Nourish lung yin, clear deficiency fire, promote the production of body fluid to quench thirst. It is indicated for chronic cough due to lung deficiency, blood loss, dry throat, thirst, deficiency heat, restlessness and fatigue.
Achyranthes bidentata has light smell, slightly sweet and astringent taste, contains a large amount of alkaloid, and has the functions of tonifying liver and kidney, strengthening muscles and bones, dredging channels and collaterals and dissipating blood stasis. The traditional Chinese medicine composition is one of the commonly used collateral-dredging and blood-activating medicines in a traditional Chinese medicine prescription for treating cold-dampness, pain in bones of waist and knees, soreness and weakness of waist and knees, spasm of limbs, irregular menstruation, postpartum blood stasis and pain in abdomen, stranguria with blood, traumatic injury, knee bending obstruction and the like.
The wild Ganoderma Applanatum, old mother fungus, maple fungus, old beef liver has effects of relieving pain, clearing heat, resolving food stagnation, stopping bleeding, and eliminating phlegm.
The invention has the beneficial effects that:
the invention provides a composition for treating diabetes and a preparation method thereof, wherein the composition is prepared by reasonably matching 6 natural traditional Chinese medicines of tartary buckwheat, Chinese yam, rhizoma polygonati, American ginseng, radix achyranthis bidentatae and wild artist's conk, the monarch, minister, assistant and guide relationships among the raw material components are clear, the synergistic effect is good, the effects of nourishing yin, tonifying spleen, supplementing qi and activating blood are skillfully combined together, the blood sugar and urine sugar can be stabilized in a normal range for a long time, and the diabetes is effectively treated.
Detailed Description
The present invention is specifically described below with reference to examples in order to facilitate understanding of the present invention by those skilled in the art. It should be particularly noted that the examples are given solely for the purpose of illustration and are not to be construed as limitations on the scope of the invention, as non-essential improvements and modifications to the invention may occur to those skilled in the art, which fall within the scope of the invention as defined by the appended claims. Meanwhile, the raw materials mentioned below are not specified in detail and are all commercially available products; the process steps or extraction methods not mentioned in detail are all process steps or extraction methods known to the person skilled in the art.
Example 1
The composition comprises the following raw material components in parts by weight: 25 parts of tartary buckwheat, 25 parts of Chinese yam, 10 parts of rhizoma polygonati, 10 parts of American ginseng, 10 parts of radix achyranthis bidentatae and 15 parts of wild Ganoderma applanatum.
The preparation method of the composition comprises the following steps: taking 25 parts of tartary buckwheat, 25 parts of Chinese yam, 10 parts of rhizoma polygonati, 10 parts of American ginseng, 10 parts of radix achyranthis bidentatae and 15 parts of wild Ganoderma applanatum in parts by weight, mixing, adding water which is 8 times of the total amount of the raw materials, soaking for 1 hour, soaking in a casserole, then decocting for 3 times, decocting for 20 minutes by adopting strong fire for the first time, decocting for 20 minutes by adopting slow fire for the rest two times, filtering, adding water which is 8 times of the total amount of the raw materials into filter residue, decocting for 30 minutes for the second time, adding water which is 8 times of the total amount of the raw materials into the filter residue after filtering, decocting for 30 minutes for the 3 rd time, combining the three decoctions, filtering, concentrating the filtrate into decoction, drying, crushing and sieving to obtain the finished product 1 of the composition for treating diabetes in the embodiment.
Example 2
The composition comprises the following raw material components in parts by weight: 35 parts of tartary buckwheat, 35 parts of Chinese yam, 20 parts of rhizoma polygonati, 20 parts of American ginseng, 12 parts of radix achyranthis bidentatae and 20 parts of wild Ganoderma applanatum.
The preparation method of the composition comprises the following steps: taking 35 parts of tartary buckwheat, 35 parts of Chinese yam, 20 parts of rhizoma polygonati, 20 parts of American ginseng, 12 parts of achyranthes bidentata and 20 parts of wild Ganoderma applanatum in parts by weight, mixing, adding water which is 10 times of the total amount of the raw materials, soaking for 1 hour, soaking in a casserole, then decocting for 3 times, decocting for 40 minutes by adopting strong fire for the first time, decocting for 40 minutes by adopting slow fire for the rest two times, filtering, adding water which is 10 times of the total amount of the raw materials into filter residue, decocting for 120 minutes for the second time, adding water which is 10 times of the total amount of the raw materials into the filter residue after filtering, decocting for 120 minutes for the 3 rd time, combining the three times of decoction, filtering, concentrating the filtrate into decoction, drying, crushing and sieving to obtain the finished product 2 of the composition for treating diabetes in the embodiment.
Example 3
The composition comprises the following raw material components in parts by weight: 30 parts of tartary buckwheat, 30 parts of Chinese yam, 15 parts of rhizoma polygonati, 15 parts of American ginseng, 11 parts of radix achyranthis bidentatae and 17.5 parts of wild Ganoderma applanatum.
The preparation method of the composition comprises the following steps: taking 30 parts of tartary buckwheat, 30 parts of Chinese yam, 15 parts of rhizoma polygonati, 15 parts of American ginseng, 11 parts of achyranthes bidentata and 17.5 parts of wild Ganoderma applanatum in parts by weight, mixing, adding water 9 times of the total amount of the raw materials, soaking for 1 hour, soaking in a casserole, decocting for 3 times, decocting for 30 minutes by adopting strong fire for the first time, decocting for 30 minutes by adopting slow fire for the rest two times, filtering, adding water 9 times of the total amount of the raw materials into filter residue, decocting for 75 minutes for the second time, adding water 9 times of the total amount of the raw materials into the filter residue after filtering, decocting for 75 minutes for the 3 rd time, combining the three decoctions, filtering, concentrating the filtrate into paste, drying, crushing and sieving to obtain the finished product 3 of the composition for treating diabetes in the embodiment.
Comparative example
The composition comprises the following raw material components in parts by weight: 30 parts of tartary buckwheat, 30 parts of Chinese yam, 15 parts of rhizoma polygonati and 11 parts of radix achyranthis bidentatae.
The preparation method of the composition comprises the following steps: taking 30 parts of tartary buckwheat, 30 parts of Chinese yam, 15 parts of rhizoma polygonati and 11 parts of radix achyranthis bidentatae according to parts by weight, mixing, adding water 9 times of the total amount of the raw material components, soaking for 1 hour, soaking in an earthen pot, then decocting for 3 times, adopting strong fire for the first time, decocting for 30 minutes, adopting slow fire for the rest two times, adding water 9 times of the total amount of the raw material components into filter residue after filtering, decocting for 75 minutes for the second time, adding water 9 times of the total amount of the raw material components into the filter residue after filtering, decocting for 75 minutes for the 3 rd time, combining the three decoctions, filtering, concentrating the filtrate into paste, drying, crushing and sieving to obtain a finished product of a comparative composition for treating diabetes.
Clinical trial
200 diabetic patients were randomly drawn, and the basic symptoms were: polyphagia, polydipsia, diuresis, emaciation. The male and female are not limited, the male and female are randomly divided into 4 groups, 50 persons are taken in each group, the first group takes the finished composition product 1 for treating diabetes of the embodiment 1, the second group takes the finished composition product 2 for treating diabetes of the embodiment 2, the third group takes the finished composition product 3 for treating diabetes of the embodiment 3, the administration is performed 3 times per day, 1 time is performed respectively in the morning, noon and evening, the patients are taken with warm boiled water after meals, the fourth group takes the finished composition comparative composition product for treating diabetes, after 3 months, the number of effective, effective and ineffective patients is counted, the total effective rate (%) is calculated, and the clinical symptoms are observed at the same time.
The curative effect standard is as follows: the method has the following advantages: the diabetic patient gradually gets better, the symptoms are obviously relieved, and the effect is obviously improved; secondly, the method is effective: the symptoms are relieved and the effect is improved to a certain extent; ③ invalid: no improvement or no significant effect. The results are shown in table 1 below:
TABLE 1 test results of the finished products obtained in examples 1-3 and comparative example, respectively, on diabetic patients
Figure BDA0002863765040000051
As can be seen by the treatment and from the records in Table 1, the three groups before taking the composition for treating diabetes all performed significantly better than the comparative example 1 of the fourth group and the comparative example 2 of the fifth group, and the symptoms of the patients in the three groups all improved (fasting blood glucose decreased to between 3.9 and 6.1 mol/L). In addition, following 1 year for 1-3 groups of cured patients, 92% of the cured patients did not experience a further increase in blood glucose to high blood glucose concentrations. Therefore, the monarch, minister, assistant and guide relationships among the raw material components are clear, the synergistic effect is good, the yin nourishing, spleen strengthening, qi tonifying and blood circulation activating effects can be ingeniously combined together, the blood sugar and urine sugar can be stabilized in normal ranges for a long time, and the diabetes can be effectively treated.
It will be obvious to those skilled in the art that many simple derivations or substitutions can be made without inventive effort without departing from the inventive concept. Therefore, simple modifications to the present invention by those skilled in the art according to the present disclosure should be within the scope of the present invention. The above embodiments are preferred embodiments of the present invention, and all similar processes and equivalent variations to those of the present invention should fall within the scope of the present invention.

Claims (10)

1. The composition is characterized by comprising the following raw material components: tartary buckwheat, Chinese yam, rhizoma polygonati, American ginseng, radix achyranthis bidentatae and wild Ganoderma applanatum.
2. The composition according to claim 1, which comprises the following raw material components in parts by weight: 20-40 parts of tartary buckwheat, 20-40 parts of Chinese yam, 5-25 parts of rhizoma polygonati, 5-25 parts of American ginseng, 8-15 parts of radix achyranthis bidentatae and 5-30 parts of wild Ganoderma applanatum.
3. The composition according to claim 1, which comprises the following raw material components in parts by weight: 25-35 parts of tartary buckwheat, 25-35 parts of Chinese yam, 10-20 parts of rhizoma polygonati, 10-20 parts of American ginseng, 10-12 parts of radix achyranthis bidentatae and 15-20 parts of wild Ganoderma applanatum.
4. The composition according to claim 1, wherein the composition is in the form of any one of tablets, granules, capsules, pills, oral liquid or syrup.
5. A process for the preparation of a composition according to any one of claims 1 to 4, characterized in that it comprises the following steps: firstly, mixing the raw material components, adding a solvent for soaking, decocting after soaking for 3 times, wherein strong fire is adopted for the first time of decoction, slow fire is adopted for the other two times of decoction, the three decoctions are combined, filtering is carried out, the filtrate is concentrated into paste, and drying is carried out, thus obtaining the composition.
6. The method according to claim 5, wherein the solvent is water.
7. The method of claim 5, wherein the decoction is carried out in an earthenware pot, an enamel pot or a stainless steel pot.
8. The method of claim 5, wherein the soaking time is 1-2 hours.
9. The preparation method according to claim 5, wherein the duration of the first decoction is 20-40 min; the rest two times of decoction lasts for 30-120 min.
10. Use of a composition according to any one of claims 1 to 4 in the manufacture of a medicament for the treatment of diabetes.
CN202011577503.7A 2020-12-28 2020-12-28 A composition for treating diabetes and preparation method thereof Withdrawn CN112587613A (en)

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Application publication date: 20210402