CN112691179A - Traditional Chinese medicine composition for losing weight and preparation method thereof - Google Patents
Traditional Chinese medicine composition for losing weight and preparation method thereof Download PDFInfo
- Publication number
- CN112691179A CN112691179A CN202110137210.5A CN202110137210A CN112691179A CN 112691179 A CN112691179 A CN 112691179A CN 202110137210 A CN202110137210 A CN 202110137210A CN 112691179 A CN112691179 A CN 112691179A
- Authority
- CN
- China
- Prior art keywords
- parts
- traditional chinese
- chinese medicine
- weight
- semen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 title claims abstract description 111
- 239000000203 mixture Substances 0.000 title claims abstract description 73
- 238000002360 preparation method Methods 0.000 title claims abstract description 15
- 210000000582 semen Anatomy 0.000 claims abstract description 51
- 244000163122 Curcuma domestica Species 0.000 claims abstract description 25
- 235000003392 Curcuma domestica Nutrition 0.000 claims abstract description 25
- 235000003373 curcuma longa Nutrition 0.000 claims abstract description 25
- 235000013976 turmeric Nutrition 0.000 claims abstract description 25
- 235000009917 Crataegus X brevipes Nutrition 0.000 claims abstract description 24
- 235000013204 Crataegus X haemacarpa Nutrition 0.000 claims abstract description 24
- 235000009685 Crataegus X maligna Nutrition 0.000 claims abstract description 24
- 235000009444 Crataegus X rubrocarnea Nutrition 0.000 claims abstract description 24
- 235000009486 Crataegus bullatus Nutrition 0.000 claims abstract description 24
- 235000017181 Crataegus chrysocarpa Nutrition 0.000 claims abstract description 24
- 235000009682 Crataegus limnophila Nutrition 0.000 claims abstract description 24
- 240000000171 Crataegus monogyna Species 0.000 claims abstract description 24
- 235000004423 Crataegus monogyna Nutrition 0.000 claims abstract description 24
- 235000002313 Crataegus paludosa Nutrition 0.000 claims abstract description 24
- 235000009840 Crataegus x incaedua Nutrition 0.000 claims abstract description 24
- 244000223760 Cinnamomum zeylanicum Species 0.000 claims abstract description 18
- 241001522129 Pinellia Species 0.000 claims abstract description 18
- 235000017803 cinnamon Nutrition 0.000 claims abstract description 18
- 240000002853 Nelumbo nucifera Species 0.000 claims abstract description 16
- 235000006508 Nelumbo nucifera Nutrition 0.000 claims abstract description 16
- 235000006510 Nelumbo pentapetala Nutrition 0.000 claims abstract description 16
- 244000197580 Poria cocos Species 0.000 claims abstract description 16
- 235000008599 Poria cocos Nutrition 0.000 claims abstract description 16
- 235000006533 astragalus Nutrition 0.000 claims abstract description 16
- 241000512259 Ascophyllum nodosum Species 0.000 claims abstract description 15
- 235000011135 Salvia miltiorrhiza Nutrition 0.000 claims abstract description 15
- 241000045403 Astragalus propinquus Species 0.000 claims abstract description 12
- 241000304195 Salvia miltiorrhiza Species 0.000 claims abstract 5
- 238000010992 reflux Methods 0.000 claims description 35
- 244000036905 Benincasa cerifera Species 0.000 claims description 34
- 235000011274 Benincasa cerifera Nutrition 0.000 claims description 34
- 238000000034 method Methods 0.000 claims description 22
- 239000012141 concentrate Substances 0.000 claims description 21
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 20
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 16
- 238000002156 mixing Methods 0.000 claims description 15
- 238000000605 extraction Methods 0.000 claims description 14
- 210000004911 serous fluid Anatomy 0.000 claims description 14
- 239000000463 material Substances 0.000 claims description 12
- 239000000706 filtrate Substances 0.000 claims description 11
- 238000001914 filtration Methods 0.000 claims description 11
- 238000004140 cleaning Methods 0.000 claims description 10
- 238000007873 sieving Methods 0.000 claims description 10
- 238000010298 pulverizing process Methods 0.000 claims description 8
- 244000062995 Cassia occidentalis Species 0.000 claims description 7
- 235000001948 Cassia occidentalis Nutrition 0.000 claims description 7
- 241001619461 Poria <basidiomycete fungus> Species 0.000 claims description 7
- 238000003756 stirring Methods 0.000 claims description 6
- 238000005303 weighing Methods 0.000 claims description 6
- 239000009636 Huang Qi Substances 0.000 claims description 5
- 244000088415 Raphanus sativus Species 0.000 claims description 5
- 235000006140 Raphanus sativus var sativus Nutrition 0.000 claims description 5
- 238000004806 packaging method and process Methods 0.000 claims description 5
- 241000893536 Epimedium Species 0.000 claims description 4
- 235000018905 epimedium Nutrition 0.000 claims description 4
- 239000002552 dosage form Substances 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 239000000243 solution Substances 0.000 claims 1
- 239000011550 stock solution Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 41
- 206010062717 Increased upper airway secretion Diseases 0.000 abstract description 18
- 208000008589 Obesity Diseases 0.000 abstract description 18
- 235000020824 obesity Nutrition 0.000 abstract description 18
- 208000026435 phlegm Diseases 0.000 abstract description 18
- 239000008280 blood Substances 0.000 abstract description 16
- 210000004369 blood Anatomy 0.000 abstract description 16
- 210000000952 spleen Anatomy 0.000 abstract description 15
- 229940079593 drug Drugs 0.000 abstract description 13
- 230000007812 deficiency Effects 0.000 abstract description 10
- 210000004185 liver Anatomy 0.000 abstract description 10
- 210000002784 stomach Anatomy 0.000 abstract description 8
- 210000003734 kidney Anatomy 0.000 abstract description 7
- 230000008901 benefit Effects 0.000 abstract description 6
- 208000031975 Yang Deficiency Diseases 0.000 abstract description 5
- 208000031971 Yin Deficiency Diseases 0.000 abstract description 5
- 229940126680 traditional chinese medicines Drugs 0.000 abstract description 5
- 206010000059 abdominal discomfort Diseases 0.000 abstract description 4
- 230000004044 response Effects 0.000 abstract description 3
- 206010067482 No adverse event Diseases 0.000 abstract description 2
- 241000699670 Mus sp. Species 0.000 description 22
- 230000000052 comparative effect Effects 0.000 description 21
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 description 14
- 208000024891 symptom Diseases 0.000 description 13
- 239000003925 fat Substances 0.000 description 11
- 102100036475 Alanine aminotransferase 1 Human genes 0.000 description 10
- 108010082126 Alanine transaminase Proteins 0.000 description 10
- 244000077995 Coix lacryma jobi Species 0.000 description 10
- 238000002474 experimental method Methods 0.000 description 10
- 244000132619 red sage Species 0.000 description 10
- 244000183685 Citrus aurantium Species 0.000 description 9
- 235000007716 Citrus aurantium Nutrition 0.000 description 9
- 241000700159 Rattus Species 0.000 description 9
- 108010003415 Aspartate Aminotransferases Proteins 0.000 description 8
- 102000004625 Aspartate Aminotransferases Human genes 0.000 description 8
- 241001465754 Metazoa Species 0.000 description 8
- 208000004880 Polyuria Diseases 0.000 description 8
- 230000035619 diuresis Effects 0.000 description 8
- 230000037396 body weight Effects 0.000 description 7
- 229940109239 creatinine Drugs 0.000 description 7
- 230000006870 function Effects 0.000 description 6
- 230000001976 improved effect Effects 0.000 description 6
- AHLBNYSZXLDEJQ-FWEHEUNISA-N orlistat Chemical compound CCCCCCCCCCC[C@H](OC(=O)[C@H](CC(C)C)NC=O)C[C@@H]1OC(=O)[C@H]1CCCCCC AHLBNYSZXLDEJQ-FWEHEUNISA-N 0.000 description 6
- 229960001243 orlistat Drugs 0.000 description 6
- 239000002002 slurry Substances 0.000 description 6
- 206010030113 Oedema Diseases 0.000 description 5
- 238000011156 evaluation Methods 0.000 description 5
- 239000000284 extract Substances 0.000 description 5
- 230000001737 promoting effect Effects 0.000 description 5
- 238000011160 research Methods 0.000 description 5
- 241000049624 Alisma plantago-aquatica subsp. orientale Species 0.000 description 4
- 241001061264 Astragalus Species 0.000 description 4
- 235000009508 confectionery Nutrition 0.000 description 4
- 230000034994 death Effects 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 235000013305 food Nutrition 0.000 description 4
- 210000004072 lung Anatomy 0.000 description 4
- 210000004233 talus Anatomy 0.000 description 4
- 206010067484 Adverse reaction Diseases 0.000 description 3
- 241000721047 Danaus plexippus Species 0.000 description 3
- 235000001188 Peltandra virginica Nutrition 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 210000000577 adipose tissue Anatomy 0.000 description 3
- 230000006838 adverse reaction Effects 0.000 description 3
- 229940107666 astragalus root Drugs 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 230000004438 eyesight Effects 0.000 description 3
- 230000002496 gastric effect Effects 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 230000033001 locomotion Effects 0.000 description 3
- 230000001717 pathogenic effect Effects 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 238000010025 steaming Methods 0.000 description 3
- 231100000331 toxic Toxicity 0.000 description 3
- 230000002588 toxic effect Effects 0.000 description 3
- 208000020154 Acnes Diseases 0.000 description 2
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 2
- 206010012735 Diarrhoea Diseases 0.000 description 2
- 241000699666 Mus <mouse, genus> Species 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 208000002193 Pain Diseases 0.000 description 2
- QNVSXXGDAPORNA-UHFFFAOYSA-N Resveratrol Natural products OC1=CC=CC(C=CC=2C=C(O)C(O)=CC=2)=C1 QNVSXXGDAPORNA-UHFFFAOYSA-N 0.000 description 2
- LUKBXSAWLPMMSZ-OWOJBTEDSA-N Trans-resveratrol Chemical compound C1=CC(O)=CC=C1\C=C\C1=CC(O)=CC(O)=C1 LUKBXSAWLPMMSZ-OWOJBTEDSA-N 0.000 description 2
- 210000001015 abdomen Anatomy 0.000 description 2
- 230000002159 abnormal effect Effects 0.000 description 2
- 210000001789 adipocyte Anatomy 0.000 description 2
- 230000006399 behavior Effects 0.000 description 2
- 238000001574 biopsy Methods 0.000 description 2
- 230000036772 blood pressure Effects 0.000 description 2
- 210000000988 bone and bone Anatomy 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 230000003750 conditioning effect Effects 0.000 description 2
- 230000002354 daily effect Effects 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 235000005911 diet Nutrition 0.000 description 2
- 230000037213 diet Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 230000035622 drinking Effects 0.000 description 2
- 230000002124 endocrine Effects 0.000 description 2
- 230000014509 gene expression Effects 0.000 description 2
- 230000002068 genetic effect Effects 0.000 description 2
- 239000003862 glucocorticoid Substances 0.000 description 2
- 239000004519 grease Substances 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 235000012054 meals Nutrition 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 210000003205 muscle Anatomy 0.000 description 2
- 231100000957 no side effect Toxicity 0.000 description 2
- 235000016709 nutrition Nutrition 0.000 description 2
- 229920001542 oligosaccharide Polymers 0.000 description 2
- 150000002482 oligosaccharides Chemical class 0.000 description 2
- 230000003285 pharmacodynamic effect Effects 0.000 description 2
- 239000000902 placebo Substances 0.000 description 2
- 229940068196 placebo Drugs 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 235000021283 resveratrol Nutrition 0.000 description 2
- 229940016667 resveratrol Drugs 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- 230000035807 sensation Effects 0.000 description 2
- 235000019615 sensations Nutrition 0.000 description 2
- 238000005728 strengthening Methods 0.000 description 2
- 230000009747 swallowing Effects 0.000 description 2
- 210000001835 viscera Anatomy 0.000 description 2
- 230000008673 vomiting Effects 0.000 description 2
- 230000004580 weight loss Effects 0.000 description 2
- LSHVYAFMTMFKBA-TZIWHRDSSA-N (-)-epicatechin-3-O-gallate Chemical compound O([C@@H]1CC2=C(O)C=C(C=C2O[C@@H]1C=1C=C(O)C(O)=CC=1)O)C(=O)C1=CC(O)=C(O)C(O)=C1 LSHVYAFMTMFKBA-TZIWHRDSSA-N 0.000 description 1
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- HOMSOWZTBJWNHP-UHFFFAOYSA-N 5-chlorothiadiazole Chemical compound ClC1=CN=NS1 HOMSOWZTBJWNHP-UHFFFAOYSA-N 0.000 description 1
- 206010000060 Abdominal distension Diseases 0.000 description 1
- 241000251468 Actinopterygii Species 0.000 description 1
- 102000014777 Adipokines Human genes 0.000 description 1
- 108010078606 Adipokines Proteins 0.000 description 1
- 102000011690 Adiponectin Human genes 0.000 description 1
- 108010076365 Adiponectin Proteins 0.000 description 1
- 229930195730 Aflatoxin Natural products 0.000 description 1
- XWIYFDMXXLINPU-UHFFFAOYSA-N Aflatoxin G Chemical compound O=C1OCCC2=C1C(=O)OC1=C2C(OC)=CC2=C1C1C=COC1O2 XWIYFDMXXLINPU-UHFFFAOYSA-N 0.000 description 1
- 241000132012 Atractylodes Species 0.000 description 1
- 208000008035 Back Pain Diseases 0.000 description 1
- 241001474374 Blennius Species 0.000 description 1
- 208000031648 Body Weight Changes Diseases 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 206010008479 Chest Pain Diseases 0.000 description 1
- 244000037364 Cinnamomum aromaticum Species 0.000 description 1
- 235000014489 Cinnamomum aromaticum Nutrition 0.000 description 1
- 206010010774 Constipation Diseases 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 208000014311 Cushing syndrome Diseases 0.000 description 1
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 description 1
- 208000016546 Distal 16p11.2 microdeletion syndrome Diseases 0.000 description 1
- 206010013954 Dysphoria Diseases 0.000 description 1
- LSHVYAFMTMFKBA-UHFFFAOYSA-N ECG Natural products C=1C=C(O)C(O)=CC=1C1OC2=CC(O)=CC(O)=C2CC1OC(=O)C1=CC(O)=C(O)C(O)=C1 LSHVYAFMTMFKBA-UHFFFAOYSA-N 0.000 description 1
- 206010016717 Fistula Diseases 0.000 description 1
- 244000119461 Garcinia xanthochymus Species 0.000 description 1
- 235000000885 Garcinia xanthochymus Nutrition 0.000 description 1
- 206010018498 Goitre Diseases 0.000 description 1
- 208000031361 Hiccup Diseases 0.000 description 1
- 208000031226 Hyperlipidaemia Diseases 0.000 description 1
- 206010020710 Hyperphagia Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 206010020850 Hyperthyroidism Diseases 0.000 description 1
- 206010058359 Hypogonadism Diseases 0.000 description 1
- TZJALUIVHRYQQB-XFDQAQKOSA-N Icariin Natural products O(C)c1ccc(C2=C(O[C@H]3[C@@H](O)[C@H](O)[C@@H](O)[C@H](C)O3)C(=O)c3c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O4)c(C/C=C(\C)/C)c3O2)cc1 TZJALUIVHRYQQB-XFDQAQKOSA-N 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 208000017170 Lipid metabolism disease Diseases 0.000 description 1
- 241000488974 Loranthus Species 0.000 description 1
- 208000008930 Low Back Pain Diseases 0.000 description 1
- 241000406668 Loxodonta cyclotis Species 0.000 description 1
- 208000037093 Menstruation Disturbances Diseases 0.000 description 1
- 206010027339 Menstruation irregular Diseases 0.000 description 1
- 235000003805 Musa ABB Group Nutrition 0.000 description 1
- 240000008790 Musa x paradisiaca Species 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
- 206010029333 Neurosis Diseases 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 241001522232 Pinellia ternata Species 0.000 description 1
- 208000014993 Pituitary disease Diseases 0.000 description 1
- 235000015266 Plantago major Nutrition 0.000 description 1
- 206010062519 Poor quality sleep Diseases 0.000 description 1
- 206010036790 Productive cough Diseases 0.000 description 1
- 206010067171 Regurgitation Diseases 0.000 description 1
- 102000007156 Resistin Human genes 0.000 description 1
- 108010047909 Resistin Proteins 0.000 description 1
- 240000007164 Salvia officinalis Species 0.000 description 1
- 206010042727 Swollen tongue Diseases 0.000 description 1
- 206010043345 Testicular pain Diseases 0.000 description 1
- 206010043354 Testicular swelling Diseases 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- 208000009453 Thyroid Nodule Diseases 0.000 description 1
- 206010047513 Vision blurred Diseases 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 231100000215 acute (single dose) toxicity testing Toxicity 0.000 description 1
- 238000011047 acute toxicity test Methods 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 210000004100 adrenal gland Anatomy 0.000 description 1
- 239000005409 aflatoxin Substances 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- 229940024606 amino acid Drugs 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 230000006793 arrhythmia Effects 0.000 description 1
- 206010003119 arrhythmia Diseases 0.000 description 1
- 235000004251 balanced diet Nutrition 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 230000004579 body weight change Effects 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 230000000711 cancerogenic effect Effects 0.000 description 1
- 230000023852 carbohydrate metabolic process Effects 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 208000026106 cerebrovascular disease Diseases 0.000 description 1
- 230000005465 channeling Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- ZPEIMTDSQAKGNT-UHFFFAOYSA-N chlorpromazine Chemical compound C1=C(Cl)C=C2N(CCCN(C)C)C3=CC=CC=C3SC2=C1 ZPEIMTDSQAKGNT-UHFFFAOYSA-N 0.000 description 1
- 229960001076 chlorpromazine Drugs 0.000 description 1
- 235000020230 cinnamon extract Nutrition 0.000 description 1
- 235000015165 citric acid Nutrition 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000005034 decoration Methods 0.000 description 1
- 230000013872 defecation Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000020595 eating behavior Effects 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 230000002996 emotional effect Effects 0.000 description 1
- 230000007368 endocrine function Effects 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 235000019197 fats Nutrition 0.000 description 1
- 235000021149 fatty food Nutrition 0.000 description 1
- 230000003890 fistula Effects 0.000 description 1
- 206010016766 flatulence Diseases 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 235000012631 food intake Nutrition 0.000 description 1
- 210000002683 foot Anatomy 0.000 description 1
- 230000002431 foraging effect Effects 0.000 description 1
- 235000015203 fruit juice Nutrition 0.000 description 1
- 230000000762 glandular Effects 0.000 description 1
- 239000000174 gluconic acid Substances 0.000 description 1
- 235000012208 gluconic acid Nutrition 0.000 description 1
- 201000003872 goiter Diseases 0.000 description 1
- 235000020717 hawthorn extract Nutrition 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000003862 health status Effects 0.000 description 1
- 206010019847 hepatosplenomegaly Diseases 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 238000000265 homogenisation Methods 0.000 description 1
- 235000003642 hunger Nutrition 0.000 description 1
- 230000002267 hypothalamic effect Effects 0.000 description 1
- 208000003532 hypothyroidism Diseases 0.000 description 1
- 230000002989 hypothyroidism Effects 0.000 description 1
- 230000000642 iatrogenic effect Effects 0.000 description 1
- TZJALUIVHRYQQB-XLRXWWTNSA-N icariin Chemical compound C1=CC(OC)=CC=C1C1=C(O[C@H]2[C@@H]([C@H](O)[C@@H](O)[C@H](C)O2)O)C(=O)C2=C(O)C=C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O)C(CC=C(C)C)=C2O1 TZJALUIVHRYQQB-XLRXWWTNSA-N 0.000 description 1
- TZJALUIVHRYQQB-UHFFFAOYSA-N icariine Natural products C1=CC(OC)=CC=C1C1=C(OC2C(C(O)C(O)C(C)O2)O)C(=O)C2=C(O)C=C(OC3C(C(O)C(O)C(CO)O3)O)C(CC=C(C)C)=C2O1 TZJALUIVHRYQQB-UHFFFAOYSA-N 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 210000003127 knee Anatomy 0.000 description 1
- 231100001231 less toxic Toxicity 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
- 201000007227 lymph node tuberculosis Diseases 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 239000002398 materia medica Substances 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 230000007721 medicinal effect Effects 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 230000027939 micturition Effects 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- 208000015238 neurotic disease Diseases 0.000 description 1
- XKLJHFLUAHKGGU-UHFFFAOYSA-N nitrous amide Chemical compound ON=N XKLJHFLUAHKGGU-UHFFFAOYSA-N 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 238000001543 one-way ANOVA Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000005813 organ abnormality Effects 0.000 description 1
- VDYCLYGKCGVBHN-UHFFFAOYSA-N pachymaic acid Natural products CC12CCC(OC(C)=O)C(C)(C)C1CCC1=C2CCC2(C)C(C(CCC(=C)C(C)C)C(O)=O)C(O)CC21C VDYCLYGKCGVBHN-UHFFFAOYSA-N 0.000 description 1
- SRDNLMOBFKJOSD-UHFFFAOYSA-N pachymic acid Natural products CC12CCC(OC(C)=O)C(C)(C)C1CCC1=C2CCC2(C)C(C(CCC=C(C)C)C(O)=O)C(O)CC21C SRDNLMOBFKJOSD-UHFFFAOYSA-N 0.000 description 1
- 230000003071 parasitic effect Effects 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 238000004634 pharmacological analysis method Methods 0.000 description 1
- 210000003800 pharynx Anatomy 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 208000017402 pituitary gland disease Diseases 0.000 description 1
- 201000010065 polycystic ovary syndrome Diseases 0.000 description 1
- 206010036067 polydipsia Diseases 0.000 description 1
- 235000017924 poor diet Nutrition 0.000 description 1
- 235000021395 porridge Nutrition 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 201000009395 primary hyperaldosteronism Diseases 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 235000005412 red sage Nutrition 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 230000007958 sleep Effects 0.000 description 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 description 1
- 208000024794 sputum Diseases 0.000 description 1
- 210000003802 sputum Anatomy 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- 229940037128 systemic glucocorticoids Drugs 0.000 description 1
- 229920001864 tannin Polymers 0.000 description 1
- 239000001648 tannin Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 210000001685 thyroid gland Anatomy 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 210000004916 vomit Anatomy 0.000 description 1
- 239000013585 weight reducing agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/02—Algae
- A61K36/03—Phaeophycota or phaeophyta (brown algae), e.g. Fucus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
- A61K36/296—Epimedium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/482—Cassia, e.g. golden shower tree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/62—Nymphaeaceae (Water-lily family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/734—Crataegus (hawthorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/884—Alismataceae (Water-plantain family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
- A61K36/8888—Pinellia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
- A61K36/8994—Coix (Job's tears)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/13—Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Botany (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Child & Adolescent Psychology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention belongs to the field of medicines, and particularly relates to a traditional Chinese medicine weight-losing composition and a preparation method thereof; the traditional Chinese medicine composition comprises, by mass, 18-25 parts of astragalus membranaceus, 5-15 parts of raw hawthorn, 5-15 parts of poria cocos, 1-10 parts of turmeric, 8-15 parts of dried lotus leaves, 10-20 parts of rhizoma alismatis, 10-20 parts of fructus aurantii, 1-8 parts of prepared pinellia ternate, 5-15 parts of exocarpium benincasae, 1-10 parts of prepared rhizoma atractylodis, 5-15 parts of semen cassiae, 1-10 parts of cinnamon, 5-15 parts of salvia miltiorrhiza, 5-15 parts of pericarpium citri reticulatae, 5-15 parts of semen benincasae, 10-20 parts of herba epimedii, 5-15 parts of kelp, 10-20 parts of semen coicis and 10-15 parts of fried semen raph. The traditional Chinese medicine composition is used for pertinently treating obesity caused by damp-heat qi deficiency, spleen deficiency damp obstruction, stomach heat damp obstruction, liver depression and qi stagnation, qi stagnation and blood stasis, turbid phlegm obstruction in middle energizer, spleen and kidney yang deficiency and yin deficiency internal heat, and has the advantages of quick response, good curative effect, no adverse reaction, short cure time, convenience in use, low treatment cost, no rebound, improvement of strange taste of traditional Chinese medicines and no gastrointestinal discomfort.
Description
Technical Field
The invention belongs to the field of medicines, and particularly relates to a traditional Chinese medicine weight-losing composition and a preparation method thereof.
Background
Obesity refers to a physiological state resulting from a significant excess of fat, a significant excess of fat layers, and a significant accumulation of body fat, especially triglycerides.
The causes of obesity can be roughly classified into five types: 1. genetic factors, the major effect of genetic factors on obesity, is through the body's susceptibility to obesity. Obese people have a significant family history; 2. endocrine factors, endocrine-secreting glucocorticoids of the adrenal gland affecting obesity, including hypothalamic, pituitary disease, cushing's syndrome, hypothyroidism, hypogonadism, polycystic ovary syndrome, etc.; 3. poor lifestyle, a person's poor lifestyle can also cause obesity. Specifically, the method comprises the following steps: excessive eating; secondly, the eating behavior is abnormal in a non-rhythm way (the times of eating, the types of foods are greasy, the time and the like); motion is little; fourthly, excessive drinking. 4. The medicinal factors, such as glucocorticoid, chlorpromazine, insulin and the like, which are used for a long time cause obesity, are iatrogenic obesity. 5. The discovery of adipocytokine, an endocrine function of adipocyte, is one of the great advances in the field of endocrinology in recent years. At present, most of adipocyte factors researched by medical scientists include adiponectin, resistin, lipid metabolism disorder and the occurrence mechanism of glycometabolism disorder, and are also one of the pathogenesis mechanisms of obesity.
The medical record of the past is very much discussed about obesity. The earliest record of this disease is described in Nei Jing, for example, in Nei Jing, there are descriptions of "Fei Gui ren" and "Wu Yang, weight, hearing and eye sight are unknown " (Su Wen. Yin Yang corresponding elephant treatise on the general treatise).
The existing weight-reducing method has the risk of gastrointestinal reaction, and the weight-reducing effect is not obvious and is easy to rebound.
The patent CN201610073460.6 discloses a composition with a weight-reducing effect and a preparation method and application thereof, wherein 3-30 parts by weight of epicatechin gallate, 8-35 parts by weight of poria peel extract, 5-35 parts by weight of cinnamon extract, 1-22 parts by weight of plantain seed extract, 1-25 parts by weight of bighead atractylodes rhizome extract and 4-23 parts by weight of parasitic loranthus extract have significant weight-reducing effect and significant blood fat-reducing effect, and are small in toxic and side effects and high in safety. But does not have intestinal discomfort caused by tuckahoe and cinnamon.
The patent CN201711428989.6 discloses a traditional Chinese medicine ointment formula for conditioning phlegm-dampness constitution and a processing method thereof, and the traditional Chinese medicine formula disclosed by the invention is used for conditioning the phlegm-dampness constitution, does not produce side effects, and does not solve the problem of weight loss.
Patent CN201710141721.8, a pharmaceutical composition containing orlistat with weight-reducing function, which contains orlistat, resveratrol and oligosaccharide. Wherein the weight ratio of orlistat to resveratrol to oligosaccharide is 1: 0.42-3.75: 0.1-0.6. The nutritional obese rat of the invention has obvious weight-losing effect, the weight-losing effect is superior to orlistat with conventional dose, the incidence rate of gastrointestinal adverse reaction is obviously lower than orlistat with conventional dose, and the problem of rough skin and pox caused by taking orlistat is not solved.
Disclosure of Invention
The invention aims to provide a weight-losing composition which is used for pertinently treating obesity caused by damp-heat qi deficiency, spleen deficiency damp obstruction, stomach heat damp obstruction, liver depression and qi stagnation, qi stagnation and blood stasis, turbid phlegm obstruction in middle energizer, spleen and kidney yang deficiency and yin deficiency internal heat, has the advantages of quick response, good curative effect, no adverse reaction, no rebound, short cure time, convenient use and low treatment cost, improves the strange taste of the traditional Chinese medicine, and does not cause gastrointestinal discomfort.
In order to realize the purpose, the invention adopts the technical scheme that:
a traditional Chinese medicine weight-losing composition comprises, by mass, 18-25 parts of astragalus membranaceus, 5-15 parts of raw hawthorn, 5-15 parts of poria cocos, 1-10 parts of turmeric, 8-15 parts of dried lotus leaves, 10-20 parts of rhizoma alismatis, 10-20 parts of fructus aurantii, 1-8 parts of prepared pinellia ternate, 5-15 parts of Chinese waxgourd peel, 1-10 parts of prepared rhizoma atractylodis, 5-15 parts of cassia occidentalis, 1-10 parts of cinnamon, 5-15 parts of salvia miltiorrhiza, 5-15 parts of dried orange peel, 5-15 parts of Chinese waxgourd seed, 10-20 parts of herba epimedii, 5-15 parts of kelp, 10-20 parts of semen coicis and 10-15 parts of fried radish seed.
Further, the traditional Chinese medicine weight-losing composition comprises, by mass, 20 parts of astragalus membranaceus, 10 parts of raw hawthorn, 10 parts of poria cocos, 8 parts of turmeric, 10 parts of dried lotus leaves, 15 parts of rhizoma alismatis, 10 parts of fructus aurantii, 5 parts of prepared pinellia ternate, 10 parts of exocarpium benincasae, 8 parts of prepared rhizoma atractylodis, 10 parts of semen cassiae, 5 parts of cinnamon, 10 parts of salvia miltiorrhiza, 10 parts of pericarpium citri reticulatae, 10 parts of semen benincasae, 15 parts of herba epimedii, 10 parts of kelp, 15 parts of semen coicis and 15 parts of fried semen raphani.
Further, the traditional Chinese medicine weight-losing composition comprises, by mass, 18 parts of astragalus membranaceus, 5 parts of raw hawthorn, 5 parts of poria cocos, 1 part of turmeric, 8 parts of dried lotus leaves, 10 parts of rhizoma alismatis, 10 parts of fructus aurantii, 1 part of prepared pinellia ternate, 5 parts of exocarpium benincasae, 1 part of prepared rhizoma atractylodis, 5 parts of semen cassiae, 1 part of cinnamon, 5 parts of salvia miltiorrhiza, 5 parts of pericarpium citri reticulatae, 5 parts of semen benincasae, 10 parts of herba epimedii, 5 parts of kelp, 10 parts of semen coicis and 10 parts of fried semen raph.
Further, the traditional Chinese medicine weight-losing composition comprises, by mass, 25 parts of astragalus membranaceus, 15 parts of raw hawthorn, 15 parts of poria cocos, 10 parts of turmeric, 15 parts of dried lotus leaves, 20 parts of rhizoma alismatis, 20 parts of fructus aurantii, 8 parts of prepared pinellia ternate, 15 parts of exocarpium benincasae, 10 parts of prepared rhizoma atractylodis, 15 parts of semen cassiae, 10 parts of cinnamon, 15 parts of salvia miltiorrhiza, 15 parts of pericarpium citri reticulatae, 15 parts of semen benincasae, 20 parts of herba epimedii, 15 parts of kelp, 20 parts of semen coicis and 15 parts of fried semen raph.
Furthermore, the traditional Chinese medicine weight-losing composition is any pharmaceutically acceptable dosage form.
Further, the traditional Chinese medicine weight-losing composition contains a pharmaceutically acceptable carrier.
Further, the traditional Chinese medicine weight-losing composition is an oral preparation.
A preparation method of a traditional Chinese medicine composition for losing weight comprises the following steps:
the method comprises the following steps: weighing the components according to the weight, selecting fresh Chinese waxgourd peel, Chinese waxgourd kernel and raw hawthorn, cleaning and dicing, cleaning bitter orange, coix seed and turmeric with water for 2-3 times, mixing the Chinese waxgourd peel, the Chinese waxgourd kernel, the raw hawthorn, the bitter orange, the coix seed and the turmeric, crushing the mixture, and sieving with a 180-mesh sieve;
step two: adding water 8-10 times the weight of the medicinal materials into the mixture obtained in the step one, carrying out three-stage reflux extraction for 0.5-1.5 hours, filtering, and concentrating the filtrate under reduced pressure to obtain a concentrate I;
step three: mixing radix astragali, Poria, dried folium Nelumbinis, Alismatis rhizoma, rhizoma Pinelliae Preparada, rhizoma Atractylodis Preparata, semen Cassiae, cortex Cinnamomi, Saviae Miltiorrhizae radix, pericarpium Citri Tangerinae, herba Epimedii, thallus laminariae, and parched Raphani semen, pulverizing, sieving with 180 mesh sieve, adding 50% ethanol solution with mass concentration of 8-10 times of the weight of the medicinal materials, performing three-stage reflux extraction for 0.5-1.5 hr each time, filtering, concentrating the filtrate under reduced pressure, and recovering ethanol to obtain concentrate II;
step four: uniformly mixing the obtained concentrate I and concentrate II; adding appropriate amount of Mel, stirring, and packaging.
Further, the Chinese medicine mixture obtained in the third step is steamed and then crushed.
Further, the concentration of the traditional Chinese medicine serous fluid entering and exiting each time in the three-stage reflux is gradually reduced, and the concentration of the traditional Chinese medicine serous fluid in the first-stage reflux is 25-40 wt%; the concentration of the traditional Chinese medicine serous fluid of the secondary reflux is 20 to 25 weight percent; the concentration of the traditional Chinese medicine serous fluid of the third-stage reflux is 15 wt% -20 wt%.
The traditional Chinese medicine comprises the following medicinal materials:
astragalus root: shichang Mi Lu & phlegm disease states that treating diseases can eliminate phlegm-dampness, and qi should be supplemented first and phlegm-resolving herbs should be added together. Astragalus root is the monarch drug and the first drug, and is a good drug for tonifying qi with a large dosage.
Dried lotus leaves: the lotus leaves contain rich nutrients such as malic acid, citric acid, gluconic acid and the like, can reduce blood fat, decompose fat and play a role in losing weight and slimming.
Rhizoma alismatis: the main function of alisma orientale is to induce diuresis and drain dampness, and the alisma orientale is found to have the function of reducing blood fat in modern pharmacology.
Fructus aurantii: fructus Aurantii is described in the book of Kaibao, and has the effects of easing joint movement, dispersing stagnation in chest, relieving distension and expelling water.
Processing pinellia ternate: it has the action of drying dampness and resolving phlegm.
White gourd peel: the Chinese waxgourd peel has the effects of inducing diuresis to alleviate edema, relieving cough and reducing sputum, and promoting diuresis and expelling pus.
Raw hawthorn: laboratory researches find that the hawthorn extract can not only block the synthesis of nitrosamine, but also inhibit the carcinogenic action of aflatoxin. The Chinese medicinal composition is widely used for reducing blood fat, reducing blood pressure, strengthening heart and preventing and resisting cancer clinically, and is a medicine which is a top-grade medicine with homology of medicine and food.
Tuckahoe, poria cocos: pachymic acid contained in Poria has effects of promoting diuresis, eliminating dampness, reducing blood sugar, enhancing immunity and resisting tumor.
Preparing rhizoma atractylodis: has effects in eliminating dampness, invigorating spleen, dispelling pathogenic wind, removing dampness, inducing perspiration, and improving eyesight.
Turmeric: the "materia Medica Yuan" says that turmeric can tonify fire and generate qi, pungent and warm can transform fire and qi can transform into qi, and qi can transform into body fluid formed in three yin of three yang, while clear can be injected into lung, turbid can go through meridian and go into sea, and blood can regulate qi and dissipate stagnation with blood excretion. Modern times, it is used to treat fullness and distention of the heart and abdomen.
And (3) cassia seed: contains multiple vitamins and abundant amino acids, fats, carbohydrates, etc. Recently, the medicine is mainly used for clearing liver fire, dispelling wind-damp, tonifying kidney, improving eyesight and the like. It is widely used for treating hyperlipidemia, hypertension, constipation, blurred vision, etc.
Cinnamon: according to the records of Rihuazi Bencao, cinnamon treats all wind-qi, tonifies internal organs and seven injuries, dredges nine orifices, benefits joints, benefits essence, warms waist and knees, breaks phlegm and has other symptoms. Cinnamon plays a role of four or two stirring jacks in a weight-reducing prescription. In many weight-reducing prescriptions in China, cinnamon is rarely used for weight reduction.
Red sage root: the book of entries recorded in the book, Dan Shen can nourish blood, remove heart and abdominal pertinacious illness and qi, strengthen waist and spine, and eliminate foot impediment, remove pathogenic wind and retain heat. Modern pharmacological research considers that the salvia miltiorrhiza has natural traditional Chinese medicines for resisting platelet aggregation, reducing the blood sugar consistency and improving cardiovascular and cerebrovascular diseases.
Dried orange peel: has effects in eliminating dampness and phlegm, invigorating spleen, stimulating appetite, regulating qi-flowing, and resolving food stagnation.
White gourd seed: the white gourd kernel is sweet in taste and slightly cold in nature, and has the effects of promoting the discharge of pus by dampness, clearing lung and eliminating phlegm. The formula comprises Chinese waxgourd peel and Chinese waxgourd kernel, which have synergistic effect.
Herba epimedii: li shi zhen yu: epimedium herb is sweet in taste and fragrant in flavor, warm in nature and cold-resistant, and can tonify essence. Modern pharmacological analysis shows that the epimedium contains icariin and has certain functions of reducing blood pressure and strengthening muscles and bones.
Kelp: according to the record of the Chinese pharmacopoeia, the kelp is a seaweed with high medicinal value. In the treatise on the herb property, it can induce diuresis, remove edema and remove malignant sores and mouse fistula. Has the main functions of softening hardness, dissipating stagnation, eliminating phlegm and promoting diuresis. Can be used for treating phlegm retention edema, goiter, scrofula, and testicular swelling and pain.
Coix seed: it is recorded in Yi Shu of the book Er Lu that it can remove the pathogenic factors of bones and muscles, promote the function of intestines and stomach, and eliminate edema, and is suitable for people to eat. The main purposes are to invigorate the spleen, promote diuresis, clear heat and tonify the lung.
Frying radish seeds: the stir-fried radish seed is pungent, sweet and flat, enters spleen, stomach and lung channels, and has the effects of promoting digestion, relieving flatulence, descending qi and reducing phlegm.
The invention has the beneficial effects that:
1. the traditional Chinese medicine weight-losing composition disclosed by the invention is used for pertinently treating obesity caused by deficiency of damp-heat qi, spleen deficiency and damp stagnation, stomach heat and damp stagnation, liver depression and qi stagnation, qi stagnation and blood stasis, turbid phlegm and middle stagnation, spleen and kidney yang deficiency and yin deficiency and internal heat, and is quick in effect, free of adverse reaction, short in cure time, free of rebound, convenient to use and low in treatment cost.
2. The traditional Chinese medicine weight-losing composition disclosed by the invention has no side effect, and the astragalus, the Chinese waxgourd peel and the processed pinellia tuber have comprehensive effects, so that the gastrointestinal discomfort caused by the processed pinellia tuber and the like in the existing weight-losing medicine is eliminated; meanwhile, three-stage reflux extraction is carried out, so that effective active components are purified, precipitates are filtered out, and the strange taste of the traditional Chinese medicine is eliminated; the cassia occidentalis, the salvia miltiorrhiza and the dried lotus leaves act together to clear away fire, remove knots, moisten the skin, achieve the purpose of unbalance water and oil on the surface of the skin of a human body, avoid acnes, acnes and the like caused by the traditional weight-reducing traditional Chinese medicine, regulate internal secretion while reducing weight and promote recovery.
3. According to the invention, a large number of experiments show that the astragalus, the rhizoma alismatis and the fructus aurantii are taken as monarch drugs, unexpected effects are achieved when the combination is applied to treating or preventing obesity, and animal experiment results show that the weight-reducing traditional Chinese medicine composition can generate a remarkable weight-reducing effect on obese rats, the weight-reducing effect is superior to other weight-reducing traditional Chinese medicines, and the incidence rate of gastrointestinal adverse reactions is remarkably lower than that of other weight-reducing traditional Chinese medicines.
4. The invention takes astragalus, alisma orientale and bitter orange as monarch drugs, and is matched with raw hawthorn, tuckahoe, turmeric, dried lotus leaves, processed pinellia ternate, Chinese waxgourd peel, processed rhizoma atractylodis, cassia occidentalis, cinnamon, salvia miltiorrhiza, dried orange peel, Chinese waxgourd seed, epimedium herb, kelp, coix seed and fried radish seed to strengthen spleen and promote diuresis, clear heat and regulate vital energy, activate blood and reduce phlegm, nourish yin and warm kidney, relieve exterior syndrome and dredge interior so as to treat obesity caused by deficiency of damp-heat and qi, spleen deficiency and damp obstruction, stomach heat and damp obstruction, liver depression and qi stagnation, qi stagnation and blood stasis, turbid phlegm and middle obstruction, kidney yang deficiency and yin deficiency and internal heat.
5. The method is provided with three-stage reflux extraction, the concentration and the component proportion of the traditional Chinese medicine extracted by reflux each time are different, the traditional Chinese medicine is subjected to reduced pressure concentration after the reflux extraction, and the impurities in the concentrate are reduced through the coordination of the traditional Chinese medicine and the component proportion, so that the insoluble traditional Chinese medicine and the traditional Chinese medicine with low solubility are left in the filtrate to be extracted after the next dissolution and filtration; the purity of the traditional Chinese medicine is improved, the solubility of the effective substances is improved, the design requirement of a subsequent process on a homogenization procedure of the traditional Chinese medicine is reduced, and the action performance of the effective components in the extracting solution is improved; meanwhile, active ingredients in the raw material medicines are retained to the greatest extent, and the problems of strange taste and difficulty in swallowing of the traditional Chinese medicine are solved.
Detailed description of the invention
The present invention is described in detail below for the purpose of better understanding technical solutions of the present invention by those skilled in the art, and the description of the present invention is only exemplary and explanatory and should not be construed as limiting the scope of the present invention in any way.
Example 1
A traditional Chinese medicine weight-losing composition comprises, by mass, 20 parts of astragalus membranaceus, 10 parts of raw hawthorn, 10 parts of poria cocos, 8 parts of turmeric, 10 parts of dried lotus leaves, 15 parts of rhizoma alismatis, 10 parts of fructus aurantii, 5 parts of prepared pinellia ternate, 10 parts of exocarpium benincasae, 8 parts of prepared rhizoma atractylodis, 10 parts of semen cassiae, 5 parts of cinnamon, 10 parts of salvia miltiorrhiza, 10 parts of pericarpium citri reticulatae, 10 parts of semen benincasae, 15 parts of herba epimedii, 10 parts of kelp, 15 parts of semen coicis and 15 parts of fried semen raphani.
The traditional Chinese medicine weight-losing composition is an oral preparation.
A preparation method of a traditional Chinese medicine composition for losing weight comprises the following steps:
the method comprises the following steps: weighing the components according to the weight, selecting fresh Chinese waxgourd peel, Chinese waxgourd kernel and raw hawthorn, cleaning and dicing, cleaning bitter orange, coix seed and turmeric with water for 2 times, mixing the Chinese waxgourd peel, the Chinese waxgourd kernel, the raw hawthorn, the bitter orange, the coix seed and the turmeric, crushing the mixture, and sieving with a 180-mesh sieve;
step two: adding water 9 times the weight of the medicinal materials into the mixture obtained in the step one, carrying out three-stage reflux extraction for 1 hour, filtering, and concentrating the filtrate under reduced pressure to obtain a concentrate I;
step three: mixing radix astragali, Poria, dried folium Nelumbinis, Alismatis rhizoma, rhizoma Pinelliae Preparada, rhizoma Atractylodis Preparata, semen Cassiae, cortex Cinnamomi, Saviae Miltiorrhizae radix, pericarpium Citri Tangerinae, herba Epimedii, thallus laminariae, and parched Raphani semen, pulverizing, sieving with 180 mesh sieve, adding ethanol solution with mass concentration of 50% 9 times of the weight of the medicinal materials, performing three-stage reflux extraction for 1 hr each time, filtering, concentrating the filtrate under reduced pressure, and recovering ethanol to obtain concentrate II; steaming the obtained Chinese medicinal mixture in the third step, and pulverizing. The concentration of the traditional Chinese medicine slurry entering and exiting liquid in each three-stage reflux is gradually reduced, and the concentration of the traditional Chinese medicine slurry in the first-stage reflux is 30 wt%; the concentration of the traditional Chinese medicine serous fluid of the secondary reflux is 24 wt%; the concentration of the traditional Chinese medicine serous fluid of the third-stage reflux is 18 wt%.
Step four: uniformly mixing the obtained concentrate I and concentrate II; adding appropriate amount of Mel, stirring, and packaging.
Example 2
A traditional Chinese medicine weight-losing composition comprises, by mass, 18 parts of astragalus membranaceus, 5 parts of raw hawthorn, 5 parts of poria cocos, 1 part of turmeric, 8 parts of dried lotus leaves, 10 parts of rhizoma alismatis, 10 parts of fructus aurantii, 1 part of prepared pinellia ternate, 5 parts of exocarpium benincasae, 1 part of prepared rhizoma atractylodis, 5 parts of semen cassiae, 1 part of cinnamon, 5 parts of salvia miltiorrhiza, 5 parts of pericarpium citri reticulatae, 5 parts of semen benincasae, 10 parts of herba epimedii, 5 parts of kelp, 10 parts of semen coicis and 10 parts of fried semen raphani.
The traditional Chinese medicine weight-losing composition is an oral preparation.
A preparation method of a traditional Chinese medicine composition for losing weight comprises the following steps:
the method comprises the following steps: weighing the components according to the weight, selecting fresh Chinese waxgourd peel, Chinese waxgourd kernel and raw hawthorn, cleaning and dicing, cleaning bitter orange, coix seed and turmeric with water for 3 times, mixing the Chinese waxgourd peel, the Chinese waxgourd kernel, the raw hawthorn, the bitter orange, the coix seed and the turmeric, crushing the mixture, and sieving with a 180-mesh sieve;
step two: adding water which is 10 times of the weight of the medicinal materials into the mixture obtained in the step one, carrying out three-stage reflux extraction for 0.5 hour, filtering, and concentrating the filtrate under reduced pressure to obtain a concentrate I;
step three: mixing radix astragali, Poria, dried folium Nelumbinis, Alismatis rhizoma, rhizoma Pinelliae Preparada, rhizoma Atractylodis Preparata, semen Cassiae, cortex Cinnamomi, Saviae Miltiorrhizae radix, pericarpium Citri Tangerinae, herba Epimedii, thallus laminariae, and parched Raphani semen, pulverizing, sieving with 180 mesh sieve, adding ethanol solution with mass concentration of 50% 8 times of the weight of the medicinal materials, performing three-stage reflux extraction for 1.5 hr each time, filtering, concentrating the filtrate under reduced pressure, and recovering ethanol to obtain concentrate II; steaming the obtained Chinese medicinal mixture in the third step, and pulverizing. The concentration of the traditional Chinese medicine slurry entering and exiting liquid in each three-stage reflux is gradually reduced, and the concentration of the traditional Chinese medicine slurry in the first-stage reflux is 25 wt%; the concentration of the traditional Chinese medicine serous fluid of the secondary reflux is 20 wt%; the concentration of the traditional Chinese medicine serous fluid of the third-stage reflux is 15 wt%.
Step four: uniformly mixing the obtained concentrate I and concentrate II; adding appropriate amount of Mel, stirring, and packaging.
Example 3
A traditional Chinese medicine weight-losing composition comprises, by mass, 25 parts of astragalus membranaceus, 15 parts of raw hawthorn, 15 parts of poria cocos, 10 parts of turmeric, 15 parts of dried lotus leaves, 20 parts of rhizoma alismatis, 20 parts of fructus aurantii, 8 parts of prepared pinellia ternate, 15 parts of exocarpium benincasae, 10 parts of prepared rhizoma atractylodis, 15 parts of semen cassiae, 10 parts of cinnamon, 15 parts of salvia miltiorrhiza, 15 parts of pericarpium citri reticulatae, 15 parts of semen benincasae, 20 parts of herba epimedii, 15 parts of kelp, 20 parts of semen coicis and 15 parts of fried semen raphani.
The traditional Chinese medicine weight-losing composition is an oral preparation.
A preparation method of a traditional Chinese medicine composition for losing weight comprises the following steps:
the method comprises the following steps: weighing the components according to the weight, selecting fresh Chinese waxgourd peel, Chinese waxgourd kernel and raw hawthorn, cleaning and dicing, cleaning bitter orange, coix seed and turmeric with water for 2 times, mixing the Chinese waxgourd peel, the Chinese waxgourd kernel, the raw hawthorn, the bitter orange, the coix seed and the turmeric, crushing the mixture, and sieving with a 180-mesh sieve;
step two: adding water which is 10 times of the weight of the medicinal materials into the mixture obtained in the step one, carrying out three-stage reflux extraction for 1.5 hours, filtering, and concentrating the filtrate under reduced pressure to obtain a concentrate I;
step three: mixing radix astragali, Poria, dried folium Nelumbinis, Alismatis rhizoma, rhizoma Pinelliae Preparada, rhizoma Atractylodis Preparata, semen Cassiae, cortex Cinnamomi, Saviae Miltiorrhizae radix, pericarpium Citri Tangerinae, herba Epimedii, thallus laminariae, and parched Raphani semen, pulverizing, sieving with 180 mesh sieve, adding 50% ethanol solution with 10 times of the weight of the medicinal materials, performing three-stage reflux extraction, each for 0.5 hr, filtering, concentrating the filtrate under reduced pressure, and recovering ethanol to obtain concentrate II; steaming the obtained Chinese medicinal mixture in the third step, and pulverizing. The concentration of the traditional Chinese medicine slurry entering and exiting liquid in each three-stage reflux is gradually reduced, and the concentration of the traditional Chinese medicine slurry in the first-stage reflux is 40 wt%; the concentration of the traditional Chinese medicine serous fluid of the secondary reflux is 25 wt%; the concentration of the traditional Chinese medicine serous fluid of the third-stage reflux is 20 wt%.
Step four: uniformly mixing the obtained concentrate I and concentrate II; adding appropriate amount of Mel, stirring, and packaging.
Comparative example 1
In this embodiment, the third-stage reflux extraction is not used in the second step and the third step, but only once, and the rest is the same as in embodiment 1.
Comparative example 2
In this example, the same amount of exocarpium benincasae was used instead of processed pinellia ternate, and the other example was the same as example 1.
Comparative example 3
In this example, the same amount of astragalus was used instead of exocarpium benincasae, and the other examples were the same as example 1.
Comparative example 4
In this example, astragalus root was not used, and the same amount of exocarpium benincasae was used instead, and the other examples were the same as example 1.
Comparative example 5
In this example, the same amount of Chinese waxgourd peel was used instead of Alisma orientale, and the other examples are the same as example 1.
Clinical curative effect
The clinical medical effect of the invention is as follows: the invention is used for carrying out systematic clinical observation on 160 patients, namely, the patients with obesity caused by damp-heat qi deficiency, spleen deficiency damp obstruction, stomach heat damp obstruction, liver depression and qi stagnation, qi stagnation and blood stasis, turbid phlegm obstruction in middle energizer, spleen and kidney yang deficiency and yin deficiency and internal heat respectively, 20 testers in each group age 18-65 years old take the traditional Chinese medicine weight-reducing medicine during treatment, and other patients take balanced diet and exercise in proper amount in 1 dose per day and 120ml per dose 2 times per day. The treatment course is 1 treatment course for 30 days, and can be taken for 2-3 treatment courses.
Matters of attention
In administration, the product can be taken with common diet, and can be taken with big fish meat and fatty food.
Diagnostic criteria:
(1) weight loss; (2) body fat percentage; (3) human BMI index; (4) waist variation.
Clinical evaluation criteria:
according to the evaluation standard of the curative effect of the traditional Chinese medicine symptoms, the integral change before and after the treatment judges the curative effect
And (3) healing: clinical symptoms and physical signs disappear or basically disappear, and the symptom score is reduced by more than or equal to 98 percent
The effect is shown: the clinical symptoms and physical signs are obviously improved, and the symptom score is reduced by more than or equal to 75 percent and less than 98 percent.
The method has the following advantages: the clinical symptoms and physical signs are all improved, and the symptom score is reduced by more than or equal to 40 percent and less than 75 percent.
And (4) invalidation: clinical symptoms and physical signs are not obviously improved, and the symptom score is reduced by less than 40 percent
The present invention will be further described with reference to specific examples.
Li Yi, Neu, 31 years old, 73 kg. The patient is always fat, but is fat and cheerful a little after the baby is born, the patient has little strength and is easy to fatigue, the patient can feel tired in the fourth floor, the patient usually does little exercise and likes silence, the patient can feel sour when the patient bends down and is dry and alive for a few minutes, and the patient squats for a few minutes to become dizzy and dark. The people feel hot, like eating cold, like drinking fruit juice and carbonated water, like drinking thin porridge but not much water, dislike fatness, sleep at night is generally 11 o' clock later, three meals are basically normal, and like boiling water to eat the once treated condition and effect when eating rice: once people eat the weight-reducing medicine Qumei and the garcinia cambogia and drink the weight-reducing tea Bishengyuan. The levo-tannin 360 weight-reducing coffee has no weight-reducing effect and is expected to help: a suitable traditional Chinese medicine weight-losing prescription with quick response, obvious effect and no side effect and an administration method are urgently required. After the traditional Chinese medicine composition for losing weight is taken for 3 months, the clinical curative effect is fully recovered, and the weight is 54 kg.
Chen is male, 40 years old, 92 kg. The patient is obese, and has symptoms of physical obesity, edema of lower limbs, short breath, no speaking desire, fatigue, weakness, loose stool, pale tongue, fat tongue and white fur. There are often behaviors of eating too late to do, inactivity, and irregular eating. After the traditional Chinese medicine composition for losing weight is taken for 3.5 months, the clinical curative effect is fully recovered, and the weight is 71 kg.
Yi in Yi, Lu, 34 years old, 63 kg. The patients are very angry, emotional, chest distress, arrhythmia, lumbago at both sides, channeling pain, foreign body sensation in pharynx, and vomiting due to general feeling of swallowing. The liver invades the spleen and stomach, and symptoms such as nausea, vomit, hiccup, acid regurgitation, poor diet, unwilling to eat, incomplete stool and the like appear. Stabbing pain in the chest and abdomen. Thyroid problems, hyperthyroidism, and even thyroid nodules. Liver depression is also manifested by neurosis, irregular menstruation and hepatosplenomegaly. After the traditional Chinese medicine composition for losing weight is taken for 3.5 months, the clinical curative effect is fully recovered, and the weight is 55 kg.
Zhao, male, age 54, 75 kg. Admission was carried out in 2017, 5 and 16. Pinsu is delicately eaten with fat, sweet and thick taste, the mouth is dry in nearly 3 months, the body weight is reduced by 7 kilograms, and the whole body is weak and gradually heavy in nearly one month, with the symptoms: dry and sticky mouth, fatigue, obvious hunger sensation before each meal, large food intake, poor sleep, sticky and greasy stool and no shape, 2-4 times a day. Pale and dark tongue with swollen tongue with teeth marks, white and greasy coating and slippery pulse. After the traditional Chinese medicine composition for losing weight is taken for 4 months, the clinical curative effect is fully recovered, and the weight is 60 kg.
By using 500 cases of the traditional Chinese medicine weight-losing composition, 460 cases are effective and 40 cases are ineffective through reasonable diet and proper amount of exercise, and the cure rate is 92%.
A Chinese medicinal composition for reducing weight
Animal and feed
Selecting healthy active male rats with the weight of 75-85 g.
2 modeling, grouping and administering
According to the pharmacodynamics research and evaluation method of obesity in traditional Chinese medicine pharmacodynamics research and evaluation, a model method for preventing obesity is adopted, 240 rats are selected as test animals and are randomly divided into 8 groups according to body weight, and n is 30 in each group. The feed and treatment medicines of each group are shown in the table. Each group of animals was provided with the corresponding feed at 10 am each day, and food was removed at 8 pm and dosed daily (feed dosing was adjusted daily on the principle that most animals had eaten). The drug treatment groups were dissolved in the feed at 10mL/kg twice a day at 9 am and 3 pm for 7 weeks. All animals were housed individually.
2.1 evaluation index
Weighing the body weight once a week; observing and counting the number of animals with oil (visible light) on hair every day, and performing comprehensive statistics according to week
3 results
Table 1, body weight change.
Table 2 number of rats with oil distribution of hair.
The results show that compared with a simple feeding nutritional feed group (a model group), the traditional Chinese medicine weight-losing composition provided by the invention has the effect of reducing the weight of rats, and the difference is very obvious (P is less than 0.01). The weight-losing effect is obvious for obese rats, and the risk of gastrointestinal discomfort caused by conventional weight-losing medicines is avoided; the probability of grease generation of the rat hair proves that the weight-reducing traditional Chinese medicine composition provided by the invention can reduce the probability of grease generation of the rat hair, and has significant difference (P <0.05) compared with a basal feed group. The medicine composition provided by the invention is a healthy weight-losing traditional Chinese medicine composition with low side effect.
Second, acute toxicity test
1 materials and methods
1.1 animals: selecting healthy and active mice with the body fat rate 5-15% higher than the normal body weight range, dividing the mice into two groups, wherein each group comprises 15 males and females, one group comprises experimental groups 1, 2 and 3, and the other group comprises a control group. Wherein, the normal weight range refers to mice with the weight of 20-25 g.
The tested drugs are: the weight-reducing traditional Chinese medicine composition prepared by the method of the embodiment 1 to 3 is fed, and the control group is fed conventionally.
1.2 Experimental methods
According to the research guidelines of new traditional Chinese medicines, in a laboratory at the room temperature of 23 ℃, mice are repeatedly pre-tested to be infused with 3250m parts of medicinal powder/k parts, the toxic reaction and death condition of the mice are observed for one week, half of death amount cannot be measured, and the maximum tolerance amount is selected for experiments.
The weight of the mice is taken as standard, the mice in the experimental group are continuously fed once every 6h according to the dosage of 0.6mg/g for one month; the blank control group is not fed with the traditional Chinese medicine weight-reducing composition, water and foraging are freely available, and the traditional Chinese medicine weight-reducing compositions of the embodiment combination comparative example group are added to the blank control group for feeding respectively in the embodiment groups 1-3 and the comparative example groups 1-5. The state of the mice was observed during the period of feeding the drug powder and two weeks after the cessation of the feeding, and the health status of the mice was judged by blood collection analysis, organ biopsy, and the like.
1.3 results of the experiment
Data processing was performed using SPSS 20.0 software, and differences between groups were analyzed using one-way anova.
Mice were not killed by the administration of the weight-reducing composition prepared in examples 1-3 for 2 months, and the biopsy of the visceral organs showed normal status and the mental status of the mice was good.
The body weight, alanine Aminotransferase (ALT), aspartate Aminotransferase (AST), and Creatinine (CRE) of each group of mice were measured and reported in Table 3.
Table 3 effect on body weight, alanine Aminotransferase (ALT), aspartate Aminotransferase (AST), Creatinine (CRE) in mice (n ═ 9).
| Group number | Body weight (g) | ALT(U/L) | ALT(U/L) | CRE(μmol/L) |
| Blank control group | 35.6±1.8 | 34.3±4.2 | 124±12.5 | 33.2±4.6 |
| EXAMPLE 1 group | 30.9±1.4 | 29.8+3.8 | 118±10.5 | 32.2±5.2 |
| EXAMPLE 2 group | 30.2±1.6 | 30.5±3.6 | 119±11.1 | 31.7±4.4 |
| EXAMPLE 3 group | 31.1±1.8 | 30.8±3.7 | 119±11.6 | 31.8±4.2 |
| Comparative example 1 group | 32.8±1.5 | 33.8±3.8 | 126±12.7 | 33.2±4.6 |
| Comparative example 2 group | 32.4±1.8 | 34.5±5.8# | 134±17.2# | 35.2±4.6 |
| Comparative example 3 group | 34.6±1.6 | 43.2±6.6# | 117±11.5 | 32.2±4.5 |
| Comparative example 4 group | 32.3±1.7 | 43.8±4.7## | 138±15.6# | 31.7±3.6 |
| Comparative example 5 group | 33.5±1.6 | 44.3±5.2# | 140±16.4# | 34.8±4.9## |
# denotes P <0.05 compared with the placebo group, and # denotes P <0.01 compared with the placebo group
(1) As can be seen from Table 3: compared with a blank control group, the alanine Aminotransferase (ALT), the aspartate Aminotransferase (AST) and the Creatinine (CRE) of the mice of the experimental groups 1 to 3 have no significant difference; after the experiment is finished, dissecting the mice, and obtaining a blank control group and an experimental group 1-3 without organ abnormality;
(2) as can be seen from Table 3: compared with the blank control group, the mice of the comparative example 4 group and the comparative example 5 group have significant difference (P <0.05), the mice of the comparative example 2 group, the comparative example 3 group, the comparative example 4 group and the comparative example 5 group have very significant difference (P <0.01) in alanine Aminotransferase (ALT), and the mice of the experimental groups 1-3 group have no significant difference in aspartate Aminotransferase (AST); after the experiment is finished, dissecting the mice, and comparing the groups of 2-4, wherein the liver color of the mice is dark; this indicates that the pinellia ternate extract in the traditional Chinese medicine weight-losing composition has certain damage to the liver of the mouse;
(3) during the experiment, the blank control group, the experimental groups 1-3 and the comparative group 1 have no death phenomenon, normal activity, normal hair, no breathing, urination, defecation and glandular secretion abnormality;
(4) during the experiment, the comparative examples have no death phenomenon, the comparative examples 2 to 5 have different degrees of dysphoria within 10 minutes after being fed with the traditional Chinese medicine weight-reducing composition and then change into quiet and idle movement, a few mice have diarrhea after 6 hours of administration, the mice gradually improve after 3 days of administration, and the behavior is normal and no other abnormal expression is seen after 10 days of administration.
5. Conclusion of the experiment
This shows that the compositions prepared in examples 1 to 3 have the advantages of significantly reduced toxic and side effects of pinellia ternata and the like, less toxic and side effects, and higher safety due to the mutual matching and combined action of the raw materials in a specific ratio.
It should be noted that, in this document, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus.
The principles and embodiments of the present invention are explained herein using specific examples, which are presented only to assist in understanding the method and its core concepts of the present invention. The foregoing is only a preferred embodiment of the present invention, and it should be noted that there are objectively infinite specific structures due to the limited character expressions, and it will be apparent to those skilled in the art that a plurality of modifications, decorations or changes may be made without departing from the principle of the present invention, and the technical features described above may be combined in a suitable manner; such modifications, variations, combinations, or adaptations of the invention using its spirit and scope, as defined by the claims, may be directed to other uses and embodiments.
Claims (10)
1. A traditional Chinese medicine weight-losing composition is characterized by comprising, by mass, 18-25 parts of astragalus membranaceus, 5-15 parts of raw hawthorn, 5-15 parts of poria cocos, 1-10 parts of turmeric, 8-15 parts of dried lotus leaves, 10-20 parts of rhizoma alismatis, 10-20 parts of fructus aurantii, 1-8 parts of processed pinellia ternate, 5-15 parts of Chinese waxgourd peel, 1-10 parts of processed rhizoma atractylodis, 5-15 parts of cassia occidentalis, 1-10 parts of cinnamon, 5-15 parts of salvia miltiorrhiza, 5-15 parts of dried orange peel, 5-15 parts of Chinese waxgourd seeds, 10-20 parts of epimedium, 5-15 parts of kelp, 10-20 parts of semen coicis and 10-15 parts of fried radish seeds.
2. The traditional Chinese medicine weight-losing composition as claimed in claim 1, which comprises, by mass, 20 parts of astragalus membranaceus, 10 parts of raw hawthorn, 10 parts of poria cocos, 8 parts of turmeric, 10 parts of dried lotus leaves, 15 parts of rhizoma alismatis, 10 parts of fructus aurantii, 5 parts of prepared pinellia ternate, 10 parts of exocarpium benincasae, 8 parts of prepared rhizoma atractylodis, 10 parts of cassia occidentalis, 5 parts of cinnamon, 10 parts of salvia miltiorrhiza, 10 parts of pericarpium citri reticulatae, 10 parts of semen benincasae, 15 parts of herba epimedii, 10 parts of kelp, 15 parts of semen coicis and 15 parts of fried semen raphani.
3. The traditional Chinese medicine weight-losing composition as claimed in claim 1, which comprises, by mass, 18 parts of astragalus membranaceus, 5 parts of raw hawthorn, 5 parts of poria cocos, 1 part of turmeric, 8 parts of dried lotus leaves, 10 parts of fructus aurantii, 1 part of processed pinellia ternate, 5 parts of exocarpium benincasae, 1 part of processed rhizoma atractylodis, 5 parts of cassia occidentalis, 1 part of cinnamon, 5 parts of salvia miltiorrhiza, 5 parts of pericarpium citri reticulatae, 5 parts of semen benincasae, 10 parts of herba epimedii, 5 parts of kelp, 10 parts of semen coicis and 10 parts of fried semen raphani.
4. The traditional Chinese medicine weight-losing composition as claimed in claim 1, which comprises, by mass, 25 parts of astragalus membranaceus, 15 parts of raw hawthorn, 15 parts of poria cocos, 10 parts of turmeric, 15 parts of dried lotus leaves, 20 parts of fructus aurantii, 8 parts of processed pinellia ternate, 15 parts of exocarpium benincasae, 10 parts of processed rhizoma atractylodis, 15 parts of cassia occidentalis, 10 parts of cinnamon, 15 parts of salvia miltiorrhiza, 15 parts of pericarpium citri reticulatae, 15 parts of semen benincasae, 20 parts of herba epimedii, 15 parts of kelp, 20 parts of semen coicis and 15 parts of fried semen raphani.
5. The traditional Chinese medicine weight-losing composition as claimed in claim 1, which is in any pharmaceutically acceptable dosage form.
6. The composition of claim 1, wherein the composition comprises a pharmaceutically acceptable carrier.
7. The traditional Chinese medicine weight-losing composition as claimed in claim 1, wherein the traditional Chinese medicine weight-losing composition is an oral preparation.
8. A preparation method of a traditional Chinese medicine composition for losing weight is characterized by comprising the following steps:
the method comprises the following steps: weighing the above components, selecting fresh Chinese waxgourd peel, Chinese waxgourd kernel and raw hawthorn, cleaning, dicing, cleaning fructus aurantii, semen coicis and turmeric with water for 2-3 times, mixing the Chinese waxgourd peel, Chinese waxgourd kernel, raw hawthorn, fructus aurantii, semen coicis and turmeric, crushing, and sieving with a 180-mesh sieve;
step two: adding water 8-10 times the weight of the medicinal materials into the mixture obtained in the step one, carrying out three-stage reflux extraction for 0.5-1.5 hours, filtering, and concentrating the filtrate under reduced pressure to obtain a concentrate I;
step three: mixing radix astragali, Poria, dried folium Nelumbinis, Alismatis rhizoma, rhizoma Pinelliae Preparada, rhizoma Atractylodis Preparata, semen Cassiae, cortex Cinnamomi, Saviae Miltiorrhizae radix, pericarpium Citri Tangerinae, herba Epimedii, thallus laminariae, and parched Raphani semen, pulverizing the mixture, sieving with 180 mesh sieve, adding 50% ethanol solution with mass concentration of 8-10 times of the weight of the medicinal materials, performing three-stage reflux extraction for 0.5-1.5 hr each time, filtering, concentrating the filtrate under reduced pressure, and recovering ethanol to obtain concentrate II;
step four: uniformly mixing the obtained concentrate I and concentrate II; adding appropriate amount of Mel, stirring, and packaging.
9. The method for preparing the traditional Chinese medicine composition for losing weight according to claim 8, wherein the traditional Chinese medicine mixture obtained in the third step is steamed and then crushed.
10. The method for preparing the composition for losing weight of traditional Chinese medicine according to claim 8, wherein the concentration of the traditional Chinese medicine serous fluid entering and exiting each time in the three-stage reflux is gradually reduced, and the concentration of the traditional Chinese medicine serous fluid in the first-stage reflux is 25 wt% -40 wt% of the traditional Chinese medicine stock solution; the concentration of the traditional Chinese medicine serous fluid of the secondary reflux is 20 to 25 weight percent; the concentration of the traditional Chinese medicine serous fluid of the third-stage reflux is 15 wt% -20 wt%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110137210.5A CN112691179A (en) | 2021-02-01 | 2021-02-01 | Traditional Chinese medicine composition for losing weight and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110137210.5A CN112691179A (en) | 2021-02-01 | 2021-02-01 | Traditional Chinese medicine composition for losing weight and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN112691179A true CN112691179A (en) | 2021-04-23 |
Family
ID=75516507
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110137210.5A Pending CN112691179A (en) | 2021-02-01 | 2021-02-01 | Traditional Chinese medicine composition for losing weight and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN112691179A (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1915399A (en) * | 2006-08-17 | 2007-02-21 | 傅家运 | Preparation for treating high blood pressure, high blood fat, obesity, and climacteric syndrome, and preparation method |
| CN104509619A (en) * | 2014-12-02 | 2015-04-15 | 南阳师范学院 | Traditional Chinese medicine fat-reducing healthy tea and preparation method thereof |
| CN105288340A (en) * | 2015-11-09 | 2016-02-03 | 陈慧珊 | Traditional Chinese medicine oral liquid for reducing weight and preparation method |
-
2021
- 2021-02-01 CN CN202110137210.5A patent/CN112691179A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1915399A (en) * | 2006-08-17 | 2007-02-21 | 傅家运 | Preparation for treating high blood pressure, high blood fat, obesity, and climacteric syndrome, and preparation method |
| CN104509619A (en) * | 2014-12-02 | 2015-04-15 | 南阳师范学院 | Traditional Chinese medicine fat-reducing healthy tea and preparation method thereof |
| CN105288340A (en) * | 2015-11-09 | 2016-02-03 | 陈慧珊 | Traditional Chinese medicine oral liquid for reducing weight and preparation method |
Non-Patent Citations (3)
| Title |
|---|
| BTV北京卫视: "国医大师的减肥调理方，有这些特征的人都该试试", 《HTTPS://BAIJIAHAO.BAIDU.COM/S?ID=1630418687822416420&WFR=SPIDER&FOR=PC》 * |
| 曾莉等主编: "《疑难病中西医诊疗指南》", 31 December 2004, 东南大学出版社 * |
| 赵东英等: "中医综合治疗单纯性肥胖30例", 《河南中医》 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102048933B (en) | Chinese medicinal composition for treating infantile diarrhea and preparation method thereof | |
| CN104322617B (en) | Biscuit of a kind of auxiliary hyperglycemic and preparation method thereof | |
| CN102319389A (en) | Medicament for treating dyspepsia | |
| CN102205107B (en) | Chinese medicinal preparation for treating duodenal ulcer and preparation method thereof | |
| CN102205108B (en) | Traditional Chinese medicine preparation for treating gastric ulcer and preparation method thereof | |
| KR100947278B1 (en) | A carbohydrate and lipid absorption inhibitory nelumbo composition and its manufacturing process thereof | |
| CN104958646A (en) | Chinese medicinal preparation for relaxing bowels and preparation method thereof | |
| CN102580048B (en) | Chinese medicine for losing weight and preparation method thereof | |
| CN106994141B (en) | Traditional Chinese medicine composition for treating constipation and preparation method thereof | |
| CN104474501A (en) | Traditional Chinese medicine preparation for treating edema and preparation method of traditional Chinese medicine preparation | |
| CN104431772A (en) | Flour-made food capable of lubricating intestines and detoxifying and preparation method of flour-made food | |
| CN104489172A (en) | Acanthopanax health tea for improving immunity and preparation method thereof | |
| CN104206595A (en) | Blood lipid and blood glucose reducing Chinese wolfberry root-bark health care tea and preparation method thereof | |
| CN105994867A (en) | Chocolate with effect of improving immunity and preparation method thereof | |
| CN104957515A (en) | Steamed buns assisting to lower blood sugar and preparation method thereof | |
| CN104825821A (en) | Medicine for treating diabetes and preparation method thereof | |
| CN104970220A (en) | Compound feed for sows in suckling period and preparation method thereof | |
| CN108186966A (en) | A kind of composition for preventing or improving senile dementia and its application | |
| CN102552743A (en) | Medicinal composition for treating diabetes and preparation method thereof | |
| CN112691179A (en) | Traditional Chinese medicine composition for losing weight and preparation method thereof | |
| CN104474103A (en) | Natural plant hypoglycemic agent and preparation method thereof | |
| CN103705835A (en) | Drug for treating cad pig and preparation method thereof | |
| CN116440224B (en) | Traditional Chinese medicine composition, preparation and preparation method | |
| KR102692595B1 (en) | Composition for treating and preventing constipation comprising Angelica gigas extract as an active ingredient | |
| CN106729584A (en) | It is a kind of to treat Chinese medicine composition of baby anorexia and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20210423 |