CN103082298B - Health-care food for reducing blood glucose in assisted mode and preparation method thereof - Google Patents
Health-care food for reducing blood glucose in assisted mode and preparation method thereof Download PDFInfo
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- CN103082298B CN103082298B CN201310018076.2A CN201310018076A CN103082298B CN 103082298 B CN103082298 B CN 103082298B CN 201310018076 A CN201310018076 A CN 201310018076A CN 103082298 B CN103082298 B CN 103082298B
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Abstract
The invention discloses a health-care food for preventing and treating diabetes in an assisted mode. The health-care food comprises the raw materials of astragalus, ginseng leaf, dried rehmannia root, pseudo-ginseng, balsam pear and chromium picolinate. According to the health-care food, the health-care effects of several components are integrated, adjuvant therapy can be performed when the diabetes patient is subjected to conventional treatment, the toxic and side effects of the medicines can be reduced, the blood sugar increase tendency can be adjusted for the crowd with high blood sugar, and the sugar tolerance of the body is enhanced.
Description
Technical field
The invention belongs to functional health-care food field, is the health food for auxiliary hyperglycemic of preparing taking Chinese herbal medicine as raw material.
Background technology
Diabetes are with insulin secretion definitely or relative deficiency, the endocrine metabolism disease that carbohydrate metabolism disturbance is main manifestations, be current harm humans health common disease, frequently-occurring disease, become the mankind's the 5th dead killer.Its characteristic shows as hyperglycaemia and glucose in urine, also comprises the disorder of fat, protein, electrolyte etc. simultaneously, often causes severe complication.Diabetes patient blood sugar's excessive concentration, easily cause glucose in urine, glucose in urine has been taken away much moisture, diuresis is asked in clinical manifestation, thirsty many drinks, and the nutriment of eating can not utilize and store in vivo, for the needed heat energy of maintenance metabolism, can only decompose and consume body fat and albumen, therefore show as Body weight loss, fatigue and weak and easily hungry many foods.The course of disease is long, treat undesirable patient easily there is cardiovascular, the cerebrovascular, kidney, eyeground retina and neural chronic disease, even causes blind and disables, and has a strong impact on health and ability to work.In addition diabetes patient is also easy to occur cutization pyogenic infection, urinary infection, pulmonary tuberculosis, fungal infection etc.Can also there is the acute complicationses such as DKA, hyperosmolar coma, lactic acidosis and life threatening in serious case.
But the generation of diabetes development be one slowly and the process of concealment, there are some researches show from blood sugar and be increased to and occur clinical symptoms, average 7 years of this one-phase, in fact slight blood sugar increases and comprises that IFG (IFG) and IGT (IGT) have damaged islet function stealthily, and has started generation and the development of vascular complication.The incidence of disease of diabetes increases year by year.Diabetes B (T2DM) the morbidity tendency that becomes younger in addition, particularly in developing country.WHO predicts 2025 and in the DM crowd of developing country, only has 26% to exceed 65 years old, and is 62% in this numeral of developed country.In addition, also have many IGT patients to fail to find in time, it is more more common than DM, thinks that at present IGT is the preliminary stage of T2DM.Therefore early detection blood sugar increases, and carries out prophylactic treatment in time, becomes the effective way of controlling diabetes on source.
Data shows, nearly 10 years is the soonest 10 years of Chinese residents diabetic quantity growth.China resident diabetes prevalence in 1978 is only 0.6% left and right.Within 1986, be within 0.9%, 1994 year, to be between 2.5%, 8 year, to increase nearly 3 times rapidly.Since the nineties in 20th century, China's economic development enters period rapid growth phase, resident's diabetes prevalence is also in ascent stage sharply, wherein 20-74 year resident's diabetes prevalence has reached 3.21%, double than nineteen ninety, annual growth reaches more than 10%, more than 1,500,000 people of net increase every year on average.And the areal variation of various places is larger, diabetes prevalence is the distribution characteristics of " high south, north is low, high in the east and low in the west " substantially.
Diabetes treatment by western medicine curative effect is fast, directly, but act on understablely, have bad reaction.Diabetes are called " diabetes " in the traditional Chinese medical science, the traditional Chinese medical science thinks that its cause of disease is mainly eating and drinking without temperance, disorder of emotion, labor and wants to be impairment of the kidney; Its interpretation of the cause, onset and process of an illness be by lung, stomach, the dirty the moon of kidney three thanks to scorching, consumption of body fluid by heat, disappear and burn water paddy and cause.Chinese traditional herbs treatment diabetes action temperature and lasting, side effect is little, and the mechanism of action has many target spots, manifold effect, multi-functional Comprehensive Characteristics.
Summary of the invention
The invention provides a kind of health food for auxiliary hyperglycemic, can when carrying out conventional therapy, diabetic carry out supplemental treatment, can reduce the toxic and side effect of medicine, can adjust the trend that increases of blood sugar for the higher crowd of blood sugar, strengthen the sugar tolerance of body.
This health food is under the guidance of theory of traditional Chinese medical science, selection can be used for article or the integration of drinking and medicinal herbs raw material of health food: the Radix Astragali, folium panacis japonici cum caule, radix rehmanniae recen, pseudo-ginseng, balsam pear, and usually used as medicine and mineral matter---the chromium picolinate of health products function factor.
The Radix Astragali has invigorating qi for strengthening superficies, pus draining and toxin expelling, and diuresis myogenic, is mainly used in the deficiency of vital energy weak, rushes down for a long time prolapse of the anus, spontaneous perspiration, oedema, the prolapse of uterus, the diseases such as chronic nephritis albuminuria, diabetes, open sore part disunion of a specified duration.Mainly contain polysaccharide, saponin(e, flavones ingredient, there is enhancing immunologic function, antiviral, improve myocardial damage, protection cardiac muscle cell, anti-inflammatory, hypoglycemic isoreactivity.
Ginseng is listed in " top grade " in Chinese medicine, is the important medicinal material of one in Chinese traditional medicine.Along with the progress of modern science and technology, people have had the understanding of upgrading to ginseng Different plant parts, and research shows, in folium panacis japonici cum caule, active ingredient and ginseng are basic identical, and some component content is even higher than root.Folium panacis japonici cum caule's hardship, sweet, cold, returns lung, stomach two warps, begins to be loaded in supplementary Amplifications of the Compendium of Materia Medica, has the functions such as " clearing lung-heat; promote the production of body fluid, quenches the thirst ", " gas drives away summer heat; fall the fire of deficiency type, the sharp four limbs head for bowl spares band table, raw stomach Tianjin ", " promote the production of body fluid and moisturize, beneficial lung and liver, tonifying vital QI ".Modern study shows, folium panacis japonici cum caule's pharmacological action is very similar to ginseng.Tumour, hepatitis, coronary heart disease, Addison's disease are had to good result for the treatment of, can strengthen corticocerebral excited process, accelerate the conduction of nerve impulse, shorten the incubation period of neural reflex, strengthen conditioned reflex, improve analysis ability; Meanwhile, folium panacis japonici cum caule also can improve the flexibility of nervous activity process; Can improve sleep and mood, improve the functions of human body such as mental, physical, have significant antifatigue, diuresis and radioresistance, hypoglycemic activity; Can increase the defence capability of body to various destructive stimuluses; Cardiac muscular dystrophy, coronary sclerosis, neurasthenia etc. are all had to certain preventive and therapeutic effect.Folium panacis japonici cum caule has been developed and has been widely used in health care industry at present, such as folium panacis japonici cum caule's tea that useful folium panacis japonici cum caule is processed into.
Radix rehmanniae recen, clearing heat and cooling blood, nourishing Yin and promoting production of body fluid, is mainly used in consumption of YIN caused by febrile disease; Diabetes; The dry constipation of intestines, warm heat disease heat enters ying blood, and heat is compeled the excessive haemorrhage that causes of blood.Contain sterols, polysaccharide, amino acid etc., have anti-ageing, regulate heart function, antiulcer, hypoglycemic, strengthen immunologic function isoreactivity and pharmacological action.
Pseudo-ginseng, scattered silt blood hemostasis, detumescence ding-tong, for hemoptysis, spit blood, have blood in stool, uterine bleeding, traumatism and bleeding, chest ventral spine pain, the diseases such as treating swelling and pain by traumatic injury.Modern study finds that it has the effect of control cardiovascular and cerebrovascular disease, improve hemorheological property, prevent thrombosis, especially evident in efficacy at aspects such as reducing blood lipid, hypoglycemic, hypotensive, anti-inflammatory, antifatigue and raising immunity of organisms, and without any side effects.
Balsam pear, is the upper conventional vegetables of daily dining table, has heat clearly and washs heat, improving eyesight, effect of removing toxic substances.Control pyreticosis polydipsia and draw drink, heatstroke, dysentery, cute conjunctivitis pain, the carbuncle erysipelas that swells, dislikes sore." the southern regions of the Yunnan Province book on Chinese herbal medicine ": " control red fiery poison gas, treat and dislike sore knot poison, or all overly become sesame furunculosis to ache unbearably." " rush down the six channels excess fire, clear heat, beneficial gas, quenches the thirst." " raw raw compile ": " except heat symptoms caused by an exopathgen, separate tiredly, improving eyesight clears away heart-fire." " book on Chinese herbal medicine is looked for the truth ": " except pyrolysis is tired of." " occupying diet spectrum with breath ": " green grass or young crops is washed heat, and improving eyesight clears away heart-fire.The ripe nourishing liver of nourishing blood, the kidney tonifying of profit spleen." " Quanzhou book on Chinese herbal medicine ": " curing mainly dysphoria with smothery sensation quenches one's thirst and draws drink, wind-heat cute conjunctivitis, heatstroke diarrhea." modern study shows, it has certain hypoglycemic activity.
Above-mentioned five kinds of combinations of substances together, from clearing heat and detoxicating moistening lung, invigorating qi for consolidating superficies, promote the production of body fluid to quench thirst, phencyclidine, blood circulation promoting and enriching is started with, and reaches hypoglycemic object.
Chromium picolinate is a kind of mineral matter, has the effect that improves islet function, is generally used for the treatment replenishers of diabetes.
The consumption of raw material components of the present invention is also groped in a large number to sum up through inventor and is drawn, each amounts of components all has good therapeutic effect within the scope of following portions by weight.
The invention provides blood sugar reducing health composition, made by the raw material of following weight portion:
Radix Astragali 3-27 part, folium panacis japonici cum caule 1-9 part, radix rehmanniae recen 1-15 part, pseudo-ginseng 1-9 part, balsam pear 4-36 part, chromium picolinate 0.00149-0.00357 part.
Be preferably:
Radix Astragali 4-18 part, folium panacis japonici cum caule 1-6 part, radix rehmanniae recen 2-12 part, pseudo-ginseng 1-6 part, balsam pear 6-20 part, chromium picolinate 0.0018-0.0033 part.
More preferably:
Radix Astragali 6-12 part, folium panacis japonici cum caule 2-5 part, radix rehmanniae recen 4-8 part, pseudo-ginseng 2-5 part, balsam pear 8-15 part, chromium picolinate 0.0020-0.0030 part.
Most preferably be:
9 parts of the Radixs Astragali, 3 parts of folium panacis japonici cum caules, 6 parts of radix rehmanniae recens, 3 parts of pseudo-ginseng, 12 parts, balsam pear, 0.00298 part of chromium picolinate.
In health-care food composition of the present invention, can add various conventional auxiliary material required while preparing different dosage form, as disintegrant, lubricant, adhesive etc. are prepared into any conventional peroral dosage form with conventional method of Chinese medicinal, as granule, pill, powder, tablet, capsule, oral liquid etc.
For example:
(1) press recipe quantity, get pseudo-ginseng, 1/3 the Radix Astragali, it is for subsequent use that mixed powder is broken into fine powder, and powder size can be whole mistake 80 mesh sieves, and 90%-95% crosses 100 mesh sieves;
(2) get chromium picolinate, be ground into fine powder for subsequent use, powder size is whole mistake 100 mesh sieves, and 90%-95% crosses 120 mesh sieves;
(3) (1) is mixed to rear common grinding with the fine powder of (2), obtain mixed powder, for subsequent use;
(4) get the remaining Radix Astragali, folium panacis japonici cum caule, radix rehmanniae recen, balsam pear, chopping, boiling secondary.Wherein add for the first time the water of 7 times of amounts, soak 1 hour, then decoct 1.5 hours, filter; Add for the second time the water of 4 times of amounts, decoct 1.5 hours, filter.The filtrate of twice decoction is merged, is evaporated to relative density 1.20-1.25(60 DEG C) medicinal extract, add the mixed powder of above-mentioned steps (3) gained, mix, 60 DEG C dry, pulverize, 75% ethanol water is granulated, whole grain, compressing tablet, to obtain final product, every 0.8g.
The object of this invention is to provide a kind of health products for auxiliary hyperglycemic, and 6 kinds of compositions that conventionally can be used for food in Chinese medicine, integration of drinking and medicinal herbs material and nutrient prime replenisher, are selected according to traditional Chinese medical theory, there are clearing heat and moistening lung, replenish qi to invigorate the spleen, promote the production of body fluid to quench thirst, enriching yin and nourishing kidney, the effect of blood circulation promoting and enriching, has for hyperglycaemia or blood sugar the crowd who increases trend.
The animal fasting blood-glucose that this health food causes alloxan increases obvious reducing effect, and can increase the sugar tolerance of hyperglycemia animal, and intact animal fasting blood-glucose is had no significant effect.
Detailed description of the invention
Further set forth below the beneficial effect of health-care food composition of the present invention by specific embodiment and test example, these test examples have comprised the auxiliary hyperglycemic function test of health products of the present invention (hereinafter to be referred as ginseng stilbene sugar health sheet).
Embodiment 1: the preparation of ginseng stilbene sugar health sheet
Radix Astragali 540g, folium panacis japonici cum caule 180g, radix rehmanniae recen 360g, pseudo-ginseng 180g, balsam pear 720g, chromium picolinate 178.8mg.
(1) press recipe quantity, get pseudo-ginseng, 1/3 Radix Astragali, it is for subsequent use that mixed powder is broken into fine powder;
(2) get chromium picolinate, be ground into fine powder for subsequent use;
(3) (1) is mixed to rear common grinding with the fine powder of (2), obtain mixed powder, for subsequent use;
(4) get the remaining Radix Astragali, folium panacis japonici cum caule, radix rehmanniae recen, balsam pear, chopping, boiling secondary.Wherein add for the first time the water of 7 times of amounts, soak 1 hour, then decoct 1.5 hours, filter; Add for the second time the water of 4 times of amounts, decoct 1.5 hours, filter.The filtrate of twice decoction is merged, is evaporated to relative density 1.20-1.25(60 DEG C) medicinal extract, add the mixed powder of above-mentioned steps (3) gained, mix, 60 DEG C dry, pulverize, 75% ethanol water is granulated, whole grain, compressing tablet, every 0.8g, to obtain final product.
Test example 1: on the impact of alloxan hyperglycemia model
One, test material
1 animal: Kunming mouse, clean level, purchased from Jilin University's Bethune medical college zoopery center, credit number: (Ji) 2007-0003.
Ginseng stilbene sugar health sheet prepared by 2 medicines and reagent: embodiment 1, is provided by Changchun University of Traditional Chinese Medicine's chemistry chamber; When test, ground, be made into uniform suspension with distilled water for subsequent use.Alloxan (C
4h
2n
2o
4h
2o): produced by United Kingdom.Blood sugar test box: Zhong Shengbeikong Bioisystech Co., Ltd produces, and glucose is produced by Beijing Chemical Plant.
Two, test method and result
1, the impact on intact animal fasting blood-glucose
Get 20 mouse, animal conformed after 1 day, was divided at random two groups: blank group, ginseng stilbene sugar health sheet 15.7g (in raw material total amount)/kg test-meal group.(water is can't help in fasting) 6h on an empty stomach, blood sugar is measured in blood sampling, and as initial blood glucose value before administration, then animal gives by group gavage, and once a day, continuous 30 days, blank group was to the distilled water 20ml/kg of same volume.Wherein after giving test-meal thing, blood sugar (before each blood sampling by animal empty stomach 6h) is measured in blood sampling in 30 days, and concrete outcome is in table 1.
Table 1. is joined the impact of stilbene sugar health sheet on intact animal fasting blood-glucose
Table 1 result is visible, and ginseng stilbene sugar health sheet has no significant effect intact animal fasting blood-glucose after test-meal in 30 days.
2, the impact on hyperglycemia model animal fasting blood-glucose
Get 72 mouse, animal conformed after 1 day, took out at random 12 animals, and by its empty stomach (water is can't help in fasting) 6h, initial blood sugar is measured in blood sampling, as all normal, using these 12 animals as blank group.Then by all the other animal hunger (water is can't help in fasting) 24h, intravenous injection alloxan 50mg/kg makes hyperglycemia model; And in injecting alloxan after 7 days, all animals are 6h on an empty stomach, blood glucose value is measured in blood sampling.Select the animal of blood sugar within the scope of 15-30mmol/L to be divided at random five groups: model group, positive drug insulin 80U/Kg group, ginseng stilbene sugar health sheet high dose 15.7g (in raw material total amount)/kg, middle dosage 7.86g (in raw material total amount)/kg, tri-dosage test-meal groups of low dosage 3.93g (in raw material total amount)/kg.Every group of blood glucose value differs and is no more than 0.1mmol/L, starts test-meal test, and once a day, gavage gives 45 days continuously, and blank group, model group and positive drug group are given same volume distilled water 20ml/kg simultaneously.Wherein after administration 21 days, 30 days, 45 days respectively blood sampling measure blood sugar (before each blood sampling by animal 6h on an empty stomach), wherein positive drug group, only in the 43rd day beginning intravenous injection insulin of other group administrations, once a day, is injected 3 days continuously.Concrete outcome is in table 2.
Table 2. join the impact of stilbene sugar health sheet on alloxan hyperamization sugar rising animal fasting blood-glucose (n=12,
)
Note: with blank group than ###P < 0.001; With model group than * P < 0.05, * * P < 0.01, the following table of * * * P < 0.001(all with)
From table 2 result, after animal injection alloxan, blood glucose value obviously raises, and has significant difference with blank group ratio; Test-meal is joined the rising of stilbene sugar health sheet high dose group blood glucose value and is starkly lower than model group after 21 days, have notable difference with model group ratio; All be starkly lower than model group to test-meal 30 days, 45 days test-meal treated animal blood glucose values.
3, the impact on hyperglycemia model animal sugar tolerance
Get 40 mouse, animal conformed after 1 day, and animal is (water is can't help in fasting) 6h on an empty stomach, and initial blood sugar is measured in blood sampling.Conforming after 1 day, hungry 24h intravenous injection alloxan 50mg/kg makes hyperglycemia model; And, after 7 days, after all animals empty stomach 6h, take a blood sample and measure blood glucose value in injection alloxan.Select the animal of blood sugar within the scope of 15-30mmol/L to be divided at random 4 groups: model group, ginseng stilbene sugar health sheet high dose 15.7g (in raw material total amount)/kg, middle dosage 7.86g (in raw material total amount)/kg, tri-dosage test-meal groups of low dosage 3.93g (in raw material total amount)/kg.Every group of blood glucose value differs and is no more than 0.1mmol/L, starts test-meal test, and once a day, gavage gives 45 days continuously, and model group is given same volume distilled water 20ml/kg simultaneously.Last gives test-meal thing first 6 hours, animal starts fasting and can't help water, after last gives test-meal thing, 20 minutes animal per os give glucose 2.0g/kg, measure to the blood glucose value of 0,0.5,2 hour after glucose, observe model control group and the each dosage group of ginseng stilbene sugar health sheet to glucose after the variation of each time point Area under the curve of blood glucose.Area under the curve of blood glucose=1/2 × (0 hours blood glucose value+0.5 hours blood glucose value) × 0.5+1/2 × (2 hours blood glucose value+0.5 hours blood glucose value) × 1.5=0.25 × (0 hours blood glucose value+3 × 2, hours blood glucose value+4 × 0.5 hours blood glucose value).The results are shown in Table 3.
Table 3. is joined the impact of stilbene sugar health sheet on hyperglycemia model animal sugar tolerance
Table 3 result shows, different time points Area under the curve of blood glucose after hyperglycemia animal oral glucose, and ginseng stilbene sugar health sheet high dose, middle dosage group are starkly lower than model control group.
The present invention fills a prescription and orally can suppress the blood sugar that alloxan causes and raise, and improves hyperglycemia animal sugar tolerance, but intact animal fasting blood-glucose is had no significant effect.Be applicable to blood sugar rising patient assistant hypoglycemic, also can be used for blood sugar has the crowd of rising trend in sub-health state simultaneously, is a health food well with auxiliary hyperglycemic function.
Claims (4)
1. a blood sugar reducing health composition, made by the raw material of following weight portion:
Radix Astragali 6-12 part, folium panacis japonici cum caule 2-5 part, radix rehmanniae recen 4-8 part, pseudo-ginseng 2-5 part, balsam pear 8-15 part, chromium picolinate 0.0020-0.0030 part; Its preparation method comprises the steps:
(1) press recipe quantity, get pseudo-ginseng, 1/3 the Radix Astragali, it is for subsequent use that mixed powder is broken into fine powder;
(2) get chromium picolinate, be ground into fine powder for subsequent use;
(3) (1) is mixed to rear common grinding with the fine powder of (2), obtain mixed powder, for subsequent use;
(4) get the remaining Radix Astragali, folium panacis japonici cum caule, radix rehmanniae recen, balsam pear, chopping, boiling secondary, wherein adds the water of 7 times of amounts for the first time, soaks 1 hour, then decocts filtration 1.5 hours; Add for the second time the water of 4 times of amounts, decoct 1.5 hours, filter, the filtrate of twice decoction is merged, relative density while being evaporated to 60 DEG C is the medicinal extract of 1.20-1.25, the mixed powder that adds above-mentioned steps (3) gained, mixes, and 60 DEG C dry, pulverize, 75% ethanol water is granulated, whole grain, compressing tablet and get final product.
2. the blood sugar reducing health composition of claim 1, made by the raw material of following weight portion:
9 parts of the Radixs Astragali, 3 parts of folium panacis japonici cum caules, 6 parts of radix rehmanniae recens, 3 parts of pseudo-ginseng, 12 parts, balsam pear, 0.00298 part of chromium picolinate.
3. the preparation method of the blood sugar reducing health composition described in any one in claim 1-2, comprises the steps:
Radix Astragali 540g, folium panacis japonici cum caule 180g, radix rehmanniae recen 360g, pseudo-ginseng 180g, balsam pear 720g, chromium picolinate 178.8mg;
(1) press recipe quantity, get pseudo-ginseng, 1/3 Radix Astragali, it is for subsequent use that mixed powder is broken into fine powder;
(2) get chromium picolinate, be ground into fine powder for subsequent use;
(3) (1) is mixed to rear common grinding with the fine powder of (2), obtain mixed powder, for subsequent use;
(4) get the remaining Radix Astragali, folium panacis japonici cum caule, radix rehmanniae recen, balsam pear, chopping, boiling secondary, wherein adds the water of 7 times of amounts for the first time, soaks 1 hour, then decocts filtration 1.5 hours; Add for the second time the water of 4 times of amounts, decoct 1.5 hours, filter, the filtrate of twice decoction is merged, and the medicinal extract that the relative density while being evaporated to 60 DEG C is 1.20-1.25, adds the mixed powder of above-mentioned steps (3) gained, mix, 60 DEG C dry, pulverize, and 75% ethanol water is granulated, whole grain, compressing tablet, every 0.8g, to obtain final product.
4. the purposes of the blood sugar reducing health composition described in any one in the health food of preparing auxiliary hyperglycemic in claim 1-2.
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| CN1726988A (en) * | 2004-07-27 | 2006-02-01 | 焦家良 | Combination of Chinese traditional medicine possessing function of regulating blood sugar, blood fat, preparation method |
| CN1748574A (en) * | 2005-10-19 | 2006-03-22 | 曲海虎 | Health food for diabetic |
| CN1947778A (en) * | 2006-11-10 | 2007-04-18 | 北京百世利康医药科技有限公司 | Hypoglycemic medicine preparation and its prepn. method |
| CN101450101A (en) * | 2007-11-30 | 2009-06-10 | 北京因科瑞斯医药科技有限公司 | Medicine composition with blood-sugar reduction function and preparation method thereof |
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| US6809115B2 (en) * | 2000-09-21 | 2004-10-26 | Nutrition 21, Inc. | Methods and compositions for the treatment of diabetes, the reduction of body fat, improvement of insulin sensitivity, reduction of hyperglycemia, and reduction of hypercholesterolemia with chromium complexes, conjugated fatty acids, and/or conjugated fatty alcohols |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1726988A (en) * | 2004-07-27 | 2006-02-01 | 焦家良 | Combination of Chinese traditional medicine possessing function of regulating blood sugar, blood fat, preparation method |
| CN1748574A (en) * | 2005-10-19 | 2006-03-22 | 曲海虎 | Health food for diabetic |
| CN1947778A (en) * | 2006-11-10 | 2007-04-18 | 北京百世利康医药科技有限公司 | Hypoglycemic medicine preparation and its prepn. method |
| CN101450101A (en) * | 2007-11-30 | 2009-06-10 | 北京因科瑞斯医药科技有限公司 | Medicine composition with blood-sugar reduction function and preparation method thereof |
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