CN101199737A - Nanometer external patch for treating cough and gasp - Google Patents
Nanometer external patch for treating cough and gasp Download PDFInfo
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- CN101199737A CN101199737A CNA2006101302894A CN200610130289A CN101199737A CN 101199737 A CN101199737 A CN 101199737A CN A2006101302894 A CNA2006101302894 A CN A2006101302894A CN 200610130289 A CN200610130289 A CN 200610130289A CN 101199737 A CN101199737 A CN 101199737A
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Abstract
The invention discloses a nanometer external-use plaster for treating cough, belonging to the medicine preparation containing the traditional herbs or the medical preparation characterized by flaky base materal. The invention is produced by the raw materials with the following parts by weight: matured Radix Ginseng, Poria, Bulbus Fritillariae Unibracteatae, Semen Armeniacae Amarum, Radix Glycyrrhizae, Lignum Aquilariae Resinatum, Fructus Schisandrae and Gekko gecko. The raw materials are crushed, arranged under CO2 supercritical extraction and distilled in a distilment tower and the liquid medicine is placed in a rubber mill for milling and then coated on the base material. The invention prepared in the way can no pollute clothes, is convenient for plastering and brings no pain to the patient. The invention is used for 290 patients and the general effective rate reaches 96.1 percent.
Description
Technical field
The present invention relates to contain the pharmaceutical preparation from traditional herbal medicines, or be the medicine configuration product of feature with the lamellar base material, specifically is a kind of nanometer external patch for the treatment of cough with asthma.
Background technology
Cough with asthma is one of main clinical manifestation of respiratory tract diseases such as chronic bronchitis.Most of patients does not heal all the year round, and is very painful, has a strong impact on patient's healthy and quality of life.Its Therapeutic Method is that antibiotics adds symptomatic treatment, and Chinese traditional treatment mostly is Chinese herbs decoction, or Chinese patent medicine preparation.A common dose is bigger, and is poor because of its mouthfeel again, bitter in the mouth, and inconvenience is taken.Dialectical opinion according to Chinese medicine treatment cough with asthma is controlled principle, and because of its type difference, prescription is different, and curative effect differs.
Chinese patent 1165021 is disclosed to be " pharmaceutical composition of treatment tracheitis, asthma " is by Radix Peucedani, Radix Glycyrrhizae, process Semen sojae atricolor, the Radix Stemonae, Radix Platycodonis, Semen Armeniacae Amarum, Bulbus Fritillariae Cirrhosae, Lignum Aquilariae Resinatum, aminophylline, disappear and cough the peaceful primary raw material that is, the bonded pharmaceutical composition of Chinese medicine and western medicine that adopts conventional preparation technology to make is used for the treatment of tracheitis, asthma.
Chinese patent 1102105 discloses a kind of " a kind of pure Chinese medicine plaster for curing cough with dyspnea ", and it can select prescription in 5～10 parts of 10～15 parts of Herba Houttuyniae, 5～12 parts in Herba Ephedrae, 5～15 parts of Semen Lepidii (Semen Descurainiae)s, 5～12 parts of Fructus Gardeniaes, 5～10 parts of the Rhizoma Pinelliaes, 5～10 parts of Pericarpium Citri Reticulataes, 5～2 parts in Semen Armeniacae Amarum, 5～10 parts in Radix Glycyrrhizae, 5～15 parts of Fructus Perillaes, 5～12 parts of Radix Scutellariaes, 5～10 parts of Radix Platycodoniss, 5～13 parts of Rhizoma Curcumae, 10～15 parts of Radix Salviae Miltiorrhizaes, Radix Et Rhizoma Rhei.But dosage form rubber-emplastrum or the powder of applying ointment or plaster as carrier with rubber plaster.Be applied to SHANZHONG acupoint, treatment tracheitis, pneumonia, inner disease outer treat, convenient and safe.
Chinese patent 1133732 discloses a kind of " cough and asthma plaster ", it boils half an hour with guaiacol and propolis under 150 ℃, again charcoal of cattle angle is added and stir, when treating that temperature drops to 80 ℃, adding Selaginella remotifolia Spring., coriander stir and make ointment, ointment is injected in the cold water again and cooled off 24 hours, last tabletting forms.That the present invention has is safe and convenient to use, need not take orally or injection, advantage such as without any side effects, and its can removing heat-phlegm, anti-inflammatory analgetic, and the cough with asthma that acute and chronic tracheitis, pneumonia, pulmonary tuberculosis and Common Cold are caused all has the effect of rapid relieving cough and asthma.Only need during use the cream sheet is affixed on " fei shu " and " Danzhong " acupuncture point of back and get final product.
Chinese patent 1422633 is disclosed to be " prescription and production technologies that the peaceful cough with asthma of speed pastes ", the proportioning of its each composition is: give birth to Radix Kansui 1-180 part, Rhizoma Pinelliae 1-180 part, give birth to Rhizoma Corydalis 1-180 part, Flos Daturae 1-180 part, Herba Asari 1-180 part, Camphora 1-100 part, Radix Aconiti Lateralis Preparata 1-10 part, Fructus Zanthoxyli 1-10 part, Alumen 1-10 part, Herba Taraxaci 1-10 part, Radix Glycyrrhizae 1-10 part, its production technology is: superfine powder is broken into 350 order fine powders after at first the above-mentioned raw materials medicine being fed intake by proportioning, b is modulated into the pasty state unguentum with new fresh ginger juice, glycerol.Spread on the acupuncture point outward, external plaster of the present invention is non-stimulated to skin, have no side effect, drug for point, warming the lung for resolving phlegm, the spleen strengthening and damp drying, boosting qi and nourishing yin, evident in efficacy and instant effect.Can be widely used in diseases such as treatment chronic bronchitis, asthma, pneumonia.
Summary of the invention
The present invention is exactly in order to solve respiratory tract disease patients' such as chronic bronchitis cough with asthma, Chinese patent medicine preparation or the decoct inconvenience problem of taking particularly, and a kind of nanometer external patch for the treatment of cough with asthma is provided.
The present invention realizes by following technical scheme.
A kind of nanometer external patch for the treatment of cough with asthma, this patch are to be made by the raw material of following weight distribution ratio: Radix Ginseng Rubra 55-65 part, Poria 50-70 part, Bulbus Fritillariae Uninbracteatae 50-70 part, Cortex Mori 50-70 part, Semen Armeniacae Amarum 130-160 part, Radix Glycyrrhizae 130-150 part, Lignum Aquilariae Resinatum 25-35 part, Fructus Schisandrae Chinensis 25-35 part, Gecko 150-200 part;
After the above-mentioned raw materials mechanical activation comminution, adopt CO
2Supercritical extraction, the fractionating column fractional distillation, the gained medicinal liquid enters colloid mill and grinds, and adds the beta cyclodextrin enclose and makes the nanoscale serosity, and enter coating machine with surfactant by a certain percentage, and coated forms on base material.
The nanometer external patch of described treatment cough with asthma, it is to be made by the raw material of following weight distribution ratio: 60 parts of Radix Ginseng Rubra, 60 parts in Poria, 60 parts of Bulbus Fritillariae Uninbracteataes, 60 parts of Cortex Mori, 150 parts in Semen Armeniacae Amarum, Radix Glycyrrhizae 150 powder, Lignum Aquilariae Resinatum 30 powder, 30 parts of Fructus Schisandrae Chinensis, 200 parts of Geckos.
The present invention who makes like this is pollution clothes not, pastes with convenient patient's no pain.Use patch of the present invention, use through clinical 29 routine patients, total effective rate reaches 96.1%.
The specific embodiment
The present invention will be described in detail below in conjunction with embodiment.
Implement sharp 1:
Take by weighing Radix Ginseng Rubra 60g, Poria 60g, Bulbus Fritillariae Uninbracteatae 60g, Cortex Mori 60g, Semen Armeniacae Amarum 150g, Radix Glycyrrhizae 150g, Lignum Aquilariae Resinatum 30g, Fructus Schisandrae Chinensis 30g, Gecko 200g (being equivalent to 2 couples).
Above-mentioned raw materials adopts CO after mechanical activation comminution
2Supercritical extraction, fractionating column add moisture and heat up in a steamer, and the gained medicinal liquid enters colloid mill and grinds, and the mill spacing is 5 μ m, slowly drips an amount of ethanol, and revolution position 3000r/min adds 3700g beta cyclodextrin enclose and makes the nanoscale serosity, 4 ℃ of cold preservation 24 hours; Sucking filtration, in 40 ℃ of vacuum dryings, with low amounts of water and washing with alcohol 3 times, 40 ℃ of return air dryings promptly get clathrate, and the method for remove enclose is to adopt the methylene chloride reflux method, extracts 30 minutes.Said medicine and pressure sensitive adhesive polyacrylate be in 1: 1 ratio, adds penetration enhancer azone mix homogeneously in the ratio of total amount 2%, enters coating machine, and coated cuts into the patch of 5 * 5cm on the substrate polyester thin film.
Implement sharp 2:
Take by weighing Radix Ginseng Rubra 60g, Poria 60g, Bulbus Fritillariae Uninbracteatae 60g, Cortex Mori 60g, Semen Armeniacae Amarum 150g, Radix Glycyrrhizae 150g, Lignum Aquilariae Resinatum 30g, Fructus Schisandrae Chinensis 30g, Gecko 200g (being equivalent to 2 couples).
Above-mentioned raw materials decocts with water twice, for the first time 10 times of water gagings, 8 times of water gagings for the second time, decocted 2 hours for the first time, decocted 1 hour for the second time, collecting decoction filters, filtrate enters colloid mill and grinds, the mill spacing is 5 μ m, slowly drips an amount of ethanol, revolution position 3000r/min, add 3700g beta cyclodextrin enclose and make the nanoscale serosity, 4 ℃ of cold preservation 24 hours; Sucking filtration, in 40 ℃ of vacuum dryings, with low amounts of water and washing with alcohol 3 times, 40 ℃ of return air dryings promptly get clathrate, and the method for remove enclose is to adopt the methylene chloride reflux method, extracts 30 minutes.Said medicine and pressure sensitive adhesive polyacrylate be in 1: 1 ratio, adds penetration enhancer azone mix homogeneously in the ratio of total amount 2%, enters coating machine, and coated cuts into the patch of 5 * 5cm on the substrate polyester thin film.Using method: patch of the present invention is attached on the Feiyu acupuncture point of patient's back, changed once in per 3 days, 7 subsides are a course of treatment.
The present invention's warp is to 141 male, and 149 women add up to 290 example treatments, wherein maximum 80 years old age, and minimal ages 3 years old, total effective rate reaches 96.1%.
The treatment standard: cough with asthma is eliminated and is produce effects; Cough with asthma obviously alleviates to effectively; Cough with asthma does not have to be alleviated to invalid.
Claims (2)
1. a nanometer external patch for the treatment of cough with asthma is characterized in that this patch is to be made by the raw material of following weight distribution ratio: Radix Ginseng Rubra 55-65 part, Poria 50-70 part, Bulbus Fritillariae Uninbracteatae 50-70 part, Cortex Mori 50-70 part, Semen Armeniacae Amarum 130-160 part, Radix Glycyrrhizae 130-150 part, Lignum Aquilariae Resinatum 25-35 part, Fructus Schisandrae Chinensis 25-35 part, Gecko 150-200 part;
After the above-mentioned raw materials mechanical activation comminution, adopt CO
2Supercritical extraction, the fractionating column fractional distillation, the gained medicinal liquid enters colloid mill and grinds, and adds the beta cyclodextrin enclose and makes the nanoscale serosity, and enter coating machine with surfactant by a certain percentage, and coated is sheared on base material and is formed.
2. the nanometer external patch of treatment cough with asthma according to claim 1 is characterized in that this patch is to be made by the raw material of following weight distribution ratio: 60 parts of Radix Ginseng Rubra, 60 parts in Poria, 60 parts of Bulbus Fritillariae Uninbracteataes, 60 parts of Cortex Mori, 150 parts in Semen Armeniacae Amarum, 150 parts in Radix Glycyrrhizae, 30 parts of Lignum Aquilariae Resinatum, 30 parts of Fructus Schisandrae Chinensis, 200 parts of Geckos.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2006101302894A CN101199737A (en) | 2006-12-15 | 2006-12-15 | Nanometer external patch for treating cough and gasp |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2006101302894A CN101199737A (en) | 2006-12-15 | 2006-12-15 | Nanometer external patch for treating cough and gasp |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101199737A true CN101199737A (en) | 2008-06-18 |
Family
ID=39515220
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2006101302894A Pending CN101199737A (en) | 2006-12-15 | 2006-12-15 | Nanometer external patch for treating cough and gasp |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101199737A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103071142A (en) * | 2013-02-26 | 2013-05-01 | 栗明峰 | Quick-acting external patch for tracheitis |
| CN113018369A (en) * | 2021-02-24 | 2021-06-25 | 曹亦徐 | Agilawood pneumonia repair liquid and preparation method thereof |
-
2006
- 2006-12-15 CN CNA2006101302894A patent/CN101199737A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103071142A (en) * | 2013-02-26 | 2013-05-01 | 栗明峰 | Quick-acting external patch for tracheitis |
| CN113018369A (en) * | 2021-02-24 | 2021-06-25 | 曹亦徐 | Agilawood pneumonia repair liquid and preparation method thereof |
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| Date | Code | Title | Description |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Open date: 20080618 |