CN101199634A - Chinese medicine patch for treating bronchitis, asthmatic disease - Google Patents
Chinese medicine patch for treating bronchitis, asthmatic disease Download PDFInfo
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- CN101199634A CN101199634A CNA2006101302860A CN200610130286A CN101199634A CN 101199634 A CN101199634 A CN 101199634A CN A2006101302860 A CNA2006101302860 A CN A2006101302860A CN 200610130286 A CN200610130286 A CN 200610130286A CN 101199634 A CN101199634 A CN 101199634A
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Abstract
The invention discloses a Chinese herbal plaster to cure bronchitis and asthma, belonging to medical preparations which contain Chinese traditional herbs or medical collocation products featuring by sheet base materials. The invention is prepared with the materials of mint, orange peel and perilla based on weight ratio through the following steps: crush the above materials, supercritically extract the materials with CO2, fractionate the materials in a fractionating tower, grind the medical liquid in a colloid mill, add Beta-cyclodextrin and pack the materials to make a nano-meter syrup, put the syrup together with surface active agent according to a certain proportion in a coating applicator and coat the syrup and the surface active agent on a base material. The invention made with such method will not dirt the clothes and causes no pain to a patient and is convenient to use. In 282 clinic cases, the plaster of the invention has an efficiency reaching 95.4%.
Description
Technical field
The present invention relates to contain the pharmaceutical preparation from traditional herbal medicines, or be the medicine configuration product of feature with the lamellar base material, specifically is a kind of Chinese herbs paste for the treatment of bronchitis, asthma.
Background technology
Asthma is one of main clinical manifestation of respiratory tract diseases such as chronic bronchitis.Most of patients does not heal all the year round, and is very painful, has a strong impact on patient's healthy and quality of life.Its Therapeutic Method is that antibiotics adds symptomatic treatment, and Chinese traditional treatment mostly is Chinese herbs decoction, or Chinese patent medicine preparation.A common dose is bigger, and is poor because of its mouthfeel again, bitter in the mouth, and inconvenience is taken.Dialectical opinion according to Chinese medicine treatment bronchitis, asthma is controlled principle, and because of its type difference, prescription is different, and curative effect differs.
Chinese patent 1165021 is disclosed to be " pharmaceutical composition of treatment tracheitis, asthma " is by Radix Peucedani, Radix Glycyrrhizae, process Semen sojae atricolor, the Radix Stemonae, Radix Platycodonis, Semen Armeniacae Amarum, Bulbus Fritillariae Cirrhosae, Lignum Aquilariae Resinatum, aminophylline, disappear and cough the peaceful primary raw material that is, the bonded pharmaceutical composition of Chinese medicine and western medicine that adopts conventional preparation technology to make is used for the treatment of tracheitis, asthma.
Chinese patent 1102105 discloses a kind of " a kind of pure Chinese medicine plaster for curing cough with dyspnea ", and it can select prescription in 5～10 parts of 10～15 parts of Herba Houttuyniae, 5～12 parts in Herba Ephedrae, 5～15 parts of Semen Lepidii (Semen Descurainiae)s, 5～12 parts of Fructus Gardeniaes, 5～10 parts of the Rhizoma Pinelliaes, 5～10 parts of Pericarpium Citri Reticulataes, 5～2 parts in Semen Armeniacae Amarum, 5～10 parts in Radix Glycyrrhizae, 5～15 parts of Fructus Perillaes, 5～12 parts of Radix Scutellariaes, 5～10 parts of Radix Platycodoniss, 5～13 parts of Rhizoma Curcumae, 10～15 parts of Radix Salviae Miltiorrhizaes, Radix Et Rhizoma Rhei.But dosage form rubber-emplastrum or the powder of applying ointment or plaster as carrier with rubber plaster.Be applied to SHANZHONG acupoint, treatment tracheitis, pneumonia, inner disease outer treat, convenient and safe.
Chinese patent 1133732 discloses a kind of " cough and asthma plaster ", it boils half an hour with guaiacol and propolis under 150 ℃, again charcoal of cattle angle is added and stir, when treating that temperature drops to 80 ℃, adding Selaginella remotifolia Spring., coriander stir and make ointment, ointment is injected in the cold water again and cooled off 24 hours, last tabletting forms.That the present invention has is safe and convenient to use, need not take orally or injection, advantage such as without any side effects, and its can removing heat-phlegm, anti-inflammatory analgetic, and the cough with asthma that acute and chronic tracheitis, pneumonia, pulmonary tuberculosis and Common Cold are caused all has the effect of rapid relieving cough and asthma.Only need during use the cream sheet is affixed on " fei shu " and " Danzhong " acupuncture point of back and get final product.
Chinese patent 1422633 is disclosed to be " prescription and production technologies that the peaceful cough with asthma of speed pastes ", the proportioning of its each composition is: give birth to Radix Kansui 1-180 part, Rhizoma Pinelliae 1-180 part, give birth to Rhizoma Corydalis 1-180 part, Flos Daturae 1-180 part, Herba Asari 1-180 part, Camphora 1-100 part, Radix Aconiti Lateralis Preparata 1-10 part, Fructus Zanthoxyli 1-10 part, Alumen 1-10 part, Herba Taraxaci 1-10 part, Radix Glycyrrhizae 1-10 part, its production technology is: superfine powder is broken into 350 order fine powders after at first the above-mentioned raw materials medicine being fed intake by proportioning, b is modulated into the pasty state unguentum with new fresh ginger juice, glycerol.Spread on the acupuncture point outward, external plaster of the present invention is non-stimulated to skin, have no side effect, drug for point, warming the lung for resolving phlegm, the spleen strengthening and damp drying, boosting qi and nourishing yin, evident in efficacy and instant effect.Can be widely used in diseases such as treatment chronic bronchitis, asthma, pneumonia.
Summary of the invention
The present invention is exactly for asthma, particularly Chinese patent medicine preparation that solves respiratory tract disease patients such as chronic bronchitis or the problem that decoct inconvenience is taken, and a kind of Chinese herbs paste for the treatment of bronchitis, asthma is provided.
The present invention realizes by following technical scheme.
A kind of Chinese herbs paste for the treatment of bronchitis, asthma, this patch are to be made by the raw material of following weight distribution ratio: Herba Menthae ginseng 10-20g, Pericarpium Citri tangerinae 5-15g, Folium Perillae 5-15g.After the above-mentioned raw materials mechanical activation comminution, adopt CO
2Supercritical extraction, the fractionating column fractional distillation, the gained medicinal liquid enters colloid mill and grinds, and adds the beta cyclodextrin enclose and makes the nanoscale serosity, and enter coating machine with surfactant by a certain percentage, and coated forms on base material.
The Chinese herbs paste of described treatment bronchitis, asthma, it is to be made by the raw material of following weight distribution ratio: Herba Menthae 15g; Pericarpium Citri tangerinae 10g; Folium Perillae 10g.
The present invention of Zhi Zuoing pollution clothes not pastes with convenient patient's no pain like this.Use patch of the present invention, use through clinical 29 routine patients, total effective rate reaches 96.1%.
The specific embodiment
The present invention will be described in detail below in conjunction with embodiment.
Implement sharp 1:
Take by weighing Herba Menthae 450g; Pericarpium Citri tangerinae 300g; Folium Perillae 300g.
Above-mentioned raw materials adopts CO after mechanical activation comminution
2Supercritical extraction, pressure 10-25Mpa, temperature 40 degree after 1.5 hours, add moisture through fractionating column and heat up in a steamer, the gained medicinal liquid enters colloid mill and grinds, the mill spacing is 5 μ m, slowly drips an amount of ethanol, revolution position 3000r/min, add 3700g beta cyclodextrin enclose and make the nanoscale serosity, 4 ℃ of cold preservation 24 hours; Sucking filtration, in 40 ℃ of vacuum dryings, with low amounts of water and washing with alcohol 3 times, 40 ℃ of return air dryings promptly get clathrate, and the method for remove enclose is to adopt the methylene chloride reflux method, extracts 30 minutes.Said medicine and pressure sensitive adhesive polyacrylate be in 1: 1 ratio, adds penetration enhancer azone mix homogeneously in the ratio of total amount 2%, enters coating machine, and coated cuts into the patch of 5 * 5cm on the substrate polyester thin film.
Implement sharp 2:
Take by weighing Herba Menthae 450g; Pericarpium Citri tangerinae 300g; Folium Perillae 300g.
Above-mentioned raw materials decocts with water twice, for the first time 10 times of water gagings, 8 times of water gagings for the second time, decocted 2 hours for the first time, decocted 1 hour for the second time, collecting decoction filters, filtrate enters colloid mill and grinds, the mill spacing is 5 μ m, slowly drips an amount of ethanol, revolution position 3000r/min, add 3700g beta cyclodextrin enclose and make the nanoscale serosity, 4 ℃ of cold preservation 24 hours; Sucking filtration, in 40 ℃ of vacuum dryings, with low amounts of water and washing with alcohol 3 times, 40 ℃ of return air dryings promptly get clathrate, and the method for remove enclose is to adopt the methylene chloride reflux method, extracts 30 minutes.Said medicine and pressure sensitive adhesive polyacrylate be in 1: 1 ratio, adds penetration enhancer azone mix homogeneously in the ratio of total amount 2%, enters coating machine, and coated cuts into the patch of 5 * 5cm on the substrate polyester thin film.Using method: patch of the present invention is attached on the Feiyu acupuncture point of patient's back, changed once in per 3 days, 7 subsides are a course of treatment.
The present invention's warp is to 150 male, and 132 women add up to 282 example treatments, wherein maximum 79 years old age, and minimal ages 6 years old, total effective rate reaches 95.4%.
The treatment standard: bronchitis, asthma are eliminated and are produce effects; Bronchitis, asthma obviously alleviate to effectively; Bronchitis, asthma do not have alleviation for invalid.
Claims (2)
1. a Chinese herbs paste for the treatment of bronchitis, asthma is characterized in that this patch is to be made by the raw material of following weight ratio: Herba Menthae ginseng 10-20g, Pericarpium Citri tangerinae 5-15g, Folium Perillae 5-15g; After the above-mentioned raw materials mechanical activation comminution, adopt CO
2Supercritical extraction, the fractionating column fractional distillation, the gained medicinal liquid enters colloid mill and grinds, and adds the beta cyclodextrin enclose and makes the nanoscale serosity, and enter coating machine with surfactant by a certain percentage, and coated is sheared on base material and is formed.
2. the Chinese herbs paste of treatment bronchitis according to claim 1, asthma is characterized in that this patch is to be made by the raw material of following weight ratio: Herba Menthae 15g; Pericarpium Citri tangerinae 10g; Folium Perillae 10g.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2006101302860A CN101199634A (en) | 2006-12-15 | 2006-12-15 | Chinese medicine patch for treating bronchitis, asthmatic disease |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2006101302860A CN101199634A (en) | 2006-12-15 | 2006-12-15 | Chinese medicine patch for treating bronchitis, asthmatic disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101199634A true CN101199634A (en) | 2008-06-18 |
Family
ID=39515116
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2006101302860A Pending CN101199634A (en) | 2006-12-15 | 2006-12-15 | Chinese medicine patch for treating bronchitis, asthmatic disease |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101199634A (en) |
-
2006
- 2006-12-15 CN CNA2006101302860A patent/CN101199634A/en active Pending
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Open date: 20080618 |