CN101559180A - Drug for clearing away heat and toxic material, relieving cough, reducing phlegm and preventing asthma - Google Patents
Drug for clearing away heat and toxic material, relieving cough, reducing phlegm and preventing asthma Download PDFInfo
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- CN101559180A CN101559180A CNA2008101043418A CN200810104341A CN101559180A CN 101559180 A CN101559180 A CN 101559180A CN A2008101043418 A CNA2008101043418 A CN A2008101043418A CN 200810104341 A CN200810104341 A CN 200810104341A CN 101559180 A CN101559180 A CN 101559180A
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Abstract
The invention discloses a drug for relieving cough and preventing asthma. The drug is made from the following materials: Chinese ephedra, amygdale, gypsum, dried tangerine peel, rice husk, tendril-leaved fritillary bulb, alum, liquorice, carbetapentane citrate, prednisone, clenbuterol and chlorphenamine. The drug treats both symptoms and causes by combination of traditional Chinese medicines and western medicines, and has efficacies of antibiosis and anti-inflammation, improvement of pulmonary circulation, enhancement of immunological function of body and the like. The drug has obvious treatment effect on bronchial asthma, tracheitis, emphysema, pulmonary heart disease and the like and has advantages of quick effect, good curative effect, high curative ratio up to 68%, high effectiveness ratio above 96%, high safety and reliability and the like without toxic side effect and adverse reaction. The drug has simple preparation method, low price, easy popularization and wide application prospect.
Description
Technical field
The medicine that the present invention relates to a kind of heat-clearing and toxic substances removing, cough-relieving, reduces phlegm, relievings asthma, particularly a kind of acute and chronic bronchitis of being used for the treatment of of Chinese herbal medicine extracting composition that contains, cold cough belongs to lung-heat disease person's medicine.
Background technology
Powerful cough-relieving medicine capsule be used for the treatment of acute and chronic bronchitis at present, cold cough belongs to one of Chinese patent medicine commonly used of lung-heat disease person, contains leaf of Flos Lonicerae maackii, Folium Rhododendri Daurici wet goods Chinese medicine in the prescription.Powerful cough-relieving medicine capsule pharmaceutical standard is recorded in Chinese traditional patent formulation preparation promulgated by the ministries or commissions of the Central Government (the 17).
Present powerful cough-relieving medicine capsule is with Oleum Rhododendri Daurici and calcium carbonate mixing, again by dilution method and the leaf of Flos Lonicerae maackii dry powder mix homogeneously of progressively increasing, incapsulate promptly, be unfavorable for keeping volatile ingredient wherein, medicine stability is low, and disintegration time is slower, dissolving slowly in vivo, bioavailability is low, needs water to swallow, and takes inconvenience.
Summary of the invention
The objective of the invention is at the powerful capsule against cough shortcoming of existing medicine, provide a kind of newtype drug that has the following advantages powerful capsule against cough: utilize to keep wherein volatile ingredient, medicine stability is good; Because than capsule 's content is liquid, medicine enters in the body and directly is easier to absorb for liquid spreads, thereby the bioavailability height; The profile slyness is flexible, swallows after the saliva moistening conveniently, and is also very suitable to inflexible old man of swallowing act or child, and patient is willing to accept.
Solution of the present invention is that existing powerful capsule against cough is changed dosage form, makes soft capsule dosage form.Its preparation method may further comprise the steps:
(1) described prescription Chinese medicine leaf of Flos Lonicerae maackii is pulverized, made solvent, carry out percolation extraction or backflow or soak extraction with 0%-100% ethanol; Or with water boiling and extraction and ethanol precipitation; Collect extracting solution, and concentrated extracting solution, drying obtains the dry extract of leaf of Flos Lonicerae maackii.
(2) described concentrated extract and Oleum Rhododendri Daurici are joined in the appropriate liquid adjuvant, mix homogeneously obtains medicinal liquid; Auxiliary Liquid Material comprises Polyethylene Glycol or vegetable oil or glycerol or propylene glycol or intermediate fatty glyceride or isopropyl alcohol or organic acid etc.
(3) it is even to make thickness after the dissolvings such as employing gelatin and glycerol, distilled water, and translucent film adopts pressing to make soft capsule; Or to utilize gelatin and oily medicinal liquid be biphase, adopts dropping preparation method to make soft capsule, through whole ball, be drying to obtain.
The invention has the beneficial effects as follows: have taking convenience, the bioavailability height is beneficial to absorption, is beneficial to preservation, volatile effective component, advantage such as medicine stability is good.
The specific embodiment
Embodiment one:
Leaf of Flos Lonicerae maackii in the described prescription is decocted with water secondary (being respectively 2,1 hours), and gradation filters, and merging filtrate left standstill 12 hours, filters, and gets the supernatant concentrating under reduced pressure and becomes thick paste, and vacuum drying is ground into fine powder, sieves; Merge with Oleum Rhododendri Daurici, it is joined in the vegetable oil, dispersed with stirring is even, obtains medicinal liquid to be processed; With described medicinal liquid pelleting in pellet processing machine, whole ball, oven dry is promptly.
Embodiment two:
Chinese medicine leaf of Flos Lonicerae maackii in the described prescription is pulverized, carried out percolation with 75% ethanol, collect extracting solution, and reclaim ethanol, concentrate drying gets dry extract; Dried cream powder is sieved after broken, pressed powder, merge with Oleum Rhododendri Daurici, it is joined in the vegetable oil, dispersed with stirring is even, obtains medicinal liquid to be processed; With described medicinal liquid pelleting in pellet processing machine, whole ball, oven dry is promptly.
Embodiment three
Chinese medicine leaf of Flos Lonicerae maackii in the described prescription is pulverized, carried out reflux, extract,, collect extracting solution with 20% ethanol, and recovery ethanol, concentrate drying gets dry extract, and dried cream powder is sieved after broken, get pressed powder, merge with Oleum Rhododendri Daurici, it is joined in the PEG400, dispersed with stirring is even, obtain medicinal liquid to be processed, with described medicinal liquid pelleting in pellet processing machine, whole ball, oven dry is promptly.
Embodiment four
Chinese medicine leaf of Flos Lonicerae maackii in the described prescription is pulverized, carried out reflux, extract,, collect extracting solution with 50% ethanol, and recovery ethanol, concentrate drying gets dry extract, and dried cream powder is sieved after broken, get pressed powder, merge, it is joined in the vegetable oil with Oleum Rhododendri Daurici, dispersed with stirring is even, obtain medicinal liquid to be processed, under the condition that keeps 80 ± 2 ℃ of steady temperatures, it is biphase utilizing gelatin and oily medicinal liquid with described medicinal liquid, drip and make ball, through cooling off, being drying to obtain.
Embodiment five
Chinese medicine leaf of Flos Lonicerae maackii in the described prescription is pulverized, and water carries out reflux, extract,, collects extracting solution, concentrates, and adds ethanol to 70% precipitation, filters, and supernatant reclaims ethanol, concentrates, gets dry extract after the drying; Dried cream powder is sieved after broken, pressed powder, merge with Oleum Rhododendri Daurici, it is joined in the vegetable oil, dispersed with stirring is even, obtains medicinal liquid to be processed, with described medicinal liquid pelleting in pellet processing machine, whole ball, oven dry promptly.
Claims (3)
1, a kind of heat-clearing and toxic substances removing, cough-relieving, the medicine that reduces phlegm, relieving asthma is characterized in that being made up of proportioning raw materials such as Herba Ephedrae, Semen Armeniacae Amarum, Gypsum Fibrosum, Radix Glycyrrhizae, Pericarpium Citri Reticulatae, Plantula Papaveris, Bulbus Fritillariae Cirrhosae.
2, according to the pharmaceutical preparation of the relieving cough and asthma under the claim 1, it is characterized in that it is a Chinese medicine preparation by the following weight proportion raw material: Herba Ephedrae 5-8 gram, Semen Armeniacae Amarum 10-12 gram, Gypsum Fibrosum 20-30 gram, Pericarpium Citri Reticulatae 10-12 gram, Plantula Papaveris 10-12 gram, Bulbus Fritillariae Cirrhosae 10-12 gram, Alumen 6-10 gram, Radix Glycyrrhizae 10-12 gram.
3,, it is characterized in that wanting to cross medicine and pulverized 100 mesh sieves, the capsule formulation instructions of taking according to the pharmaceutical preparation under claim 1 or 2.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008101043418A CN101559180A (en) | 2008-04-17 | 2008-04-17 | Drug for clearing away heat and toxic material, relieving cough, reducing phlegm and preventing asthma |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008101043418A CN101559180A (en) | 2008-04-17 | 2008-04-17 | Drug for clearing away heat and toxic material, relieving cough, reducing phlegm and preventing asthma |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101559180A true CN101559180A (en) | 2009-10-21 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2008101043418A Withdrawn CN101559180A (en) | 2008-04-17 | 2008-04-17 | Drug for clearing away heat and toxic material, relieving cough, reducing phlegm and preventing asthma |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101559180A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103182046A (en) * | 2013-03-22 | 2013-07-03 | 陈欣 | Traditional Chinese medicine granule for treating pulmonary heart disease, and preparation method thereof |
| CN104069227A (en) * | 2014-07-23 | 2014-10-01 | 河南中医学院 | Traditional Chinese medicine for treating coughing, phlegm, and asthma |
-
2008
- 2008-04-17 CN CNA2008101043418A patent/CN101559180A/en not_active Withdrawn
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103182046A (en) * | 2013-03-22 | 2013-07-03 | 陈欣 | Traditional Chinese medicine granule for treating pulmonary heart disease, and preparation method thereof |
| CN104069227A (en) * | 2014-07-23 | 2014-10-01 | 河南中医学院 | Traditional Chinese medicine for treating coughing, phlegm, and asthma |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C04 | Withdrawal of patent application after publication (patent law 2001) | ||
| WW01 | Invention patent application withdrawn after publication |