CN101428134A - Process for producing four-Tibet inula root soft capsule - Google Patents
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- CN101428134A CN101428134A CNA2008101479319A CN200810147931A CN101428134A CN 101428134 A CN101428134 A CN 101428134A CN A2008101479319 A CNA2008101479319 A CN A2008101479319A CN 200810147931 A CN200810147931 A CN 200810147931A CN 101428134 A CN101428134 A CN 101428134A
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Abstract
The invention relates to a Tibetan medicine, in particular to a preparation method of a four-medicine Tibetan costustoot soft capsule. The four-medicine Tibetan costustoot soft capsule is prepared by the following raw materials by parts by weight: wood of juteleaf raspberry: Tibetan costustoot: caulis tinosporae: dried ginger is equal to 2: 1: 1: 0.5; the preparation process is as follows: 1) the CO2 supercritical extraction of the herbal medicines of the Tibetan costustoot and the dried ginger is carried out; 2) the ethanol reflux extraction of the wood of juteleaf raspberry and the caulis tinosporae is carried out; 3) the residues of the Tibetan costustoot and the dried ginger and the residues of the wood of juteleaf raspberry and the caulis tinosporae are decocted by adding water, filtered and concentrated to obtain liquid extracts prepared by water extraction; 4) the liquid extracts are merged, dried, smashed and screened to obtain liquid extract powder; and 5) volatile oil and the dry liquid extract powder are added in a matrix, liquid medicine is pressed to pills by using a soft capsule machine, and the drying is carried out for preparation. The four-medicine Tibetan costustoot soft capsule learns from and introduces a plurality of new processes, new technologies, new excipients and new equipment at the same time of improving the medicine quality of the Tibetan medicine, thereby improving the preparation stability and the bioavailability, combining the traditional Tibetan medicine with the modern preparation method and opening up a road for the reasonable development of the Tibetan medicine.
Description
Technical field
The present invention relates to a kind of Tibetan medicine, specifically relate to a kind of process for producing four-Tibet inula root soft capsule.
SIWEI ZANGMUXIANG TANGSAN (Manubzhithang) comes from the existing medical science ancient books and records " month king's medicine treasure " and the Four-Volume Medical Code the earliest of Tibetan medicine, the historical records in existing more than 1300 year." month king's medicine treasure " record: " XUANGOUMU (Kandrakari), Herba Lycopodii (Sletres), Rhizoma Zingiberis (Sgaskya), Radix Inulae (Manu) four flavors are fried in shallow oil soup and are taken orally, cure saliva and sputum disorder, hypopnea, and inappetence, the both sides of the chest twinge mixes infectious disease ".Four-Volume Medical Code record: " it is for oral administration that Radix Inulae (Manu), XUANGOUMU (Kandrakari), Herba Lycopodii (Sletres), Rhizoma Zingiberis (Sgaskya) are fried in shallow oil soup, impels the plague fever molding, cures mainly Bacon's wooden cloth sickness, asthenia pyrosyndrome, pain due to blood stasis ".
The former prescription of four-Tibet inula root is Radix Inulae 100g, XUANGOUMU 30g, Herba Lycopodii 100g, Rhizoma Zingiberis 25g, and be powder, traditional instructions of taking is for oral administration for four flavors are fried in shallow oil soup, or four Chinese medicine is ground into coarse powder, sieves, and is turbid even, when taking with being decocted in water for oral dose.Although it has the wider scope of application and therapeutical effect preferably, original technology simple coarse, dosage form is difficult for storage and transport.And the extracting method of volatile oil is a steam distillation in original Radix Inulae, and its extract alantolactone and volatile oil contents are lower.
Summary of the invention
The technical problem to be solved in the present invention is at the deficiencies in the prior art, and a kind of process for producing four-Tibet inula root soft capsule is provided.
A kind of process for producing four-Tibet inula root soft capsule of the present invention is achieved by following technical proposals: a kind of four-Tibet inula root capsule of the present invention is made by the raw material of following weight parts: XUANGOUMU: Radix Inulae: Herba Lycopodii: Rhizoma Zingiberis=2: 1: 1: 0.5; Its preparation technology:
1) be that Radix Inulae and Rhizoma Zingiberis medical material merge employing CO
2Supercritical extraction, getting extract is volatile oil, standby;
2) XUANGOUMU and Herba Lycopodii medical material alcohol reflux merge alcohol reflux liquid, reclaim ethanol, get alcohol-extracted extract, and be standby;
3) with Radix Inulae and Rhizoma Zingiberis CO
2Medicinal residues behind medicinal residues behind the supercritical extraction and XUANGOUMU and the Herba Lycopodii alcohol reflux decoct with water, and filter, and merge decoction liquor, and normal pressure concentrates, and get the water extracted immersing paste, and are standby;
4) merge the water extracted immersing paste and alcohol-extracted extract, the reduced vacuum drying, crushing screening gets water and carries and the alcohol extraction dry extract, and is standby;
5) volatile oil, dry extract are joined in the substrate of diluent, suspending agent, wetting agent composition, stir, after further grinding, medicinal liquid is transferred in the liquid storage filling of encapsulating machine, regulate loading amount, be pressed into ball;
6) finalize the design, wash ball, be drying to obtain.
A kind of process for producing four-Tibet inula root soft capsule of the present invention has following beneficial effect compared with prior art: according to the chemical constituent character of each medicine in the side, its main effective ingredient is the volatile oil composition in the Radix Inulae, as alantolactone and isoalantolactone.Also contain more volatile ingredient in the Rhizoma Zingiberis.Therefore, consider to use extraction new technique-CO
2Volatile oil composition in the supercritical extraction acquisition side.This extracting method separation efficiency height, mass transfer rate is fast, and penetrating power is strong, and solvability is strong, and evaporation latent heat is low, and selectivity is easy to regulate.Operating process is simple, step is few, weak point consuming time, and is to carry out under the dynamic condition of Continuous Flow, and extraction product constantly is removed, and extracts fully, can make full use of valuable natural resources of Chinese medicinal materials.Can not produce any new ＂ three wastes ＂ material, very favourable to environmental conservation.CO
2Cheap and easy to get, its critical temperature and critical pressure are low, are easy in the operation realize, and can be recycled, and the full cost of product is greatly reduced.Because the volatile oil composition is liquid or semisolid at normal temperatures, makes preparation and adopts technical finesses such as absorption, curing often.Add adjuvants such as absorbent, the dosage form volume will be increased; Handle as carrying out heat drying in the preparation, medicine easily dissociates from adjuvants such as absorbent again and oozes out, and can make loss of effective components, affects the treatment.Soft capsule is with the fat-soluble solvent dissolving or make emulsion and fill with oiliness medicine and low melting point substance, saved the absorption adjuvant, make the preparation formulation volume-diminished, problems such as medicine oozes out have been avoided simultaneously, and can improve bioavailability, so for this class medicine, soft capsule is more suitable dosage form.Therefore, be extracted as the master with volatile oil, on the basis of bound water alcohol extraction, according to the prescription function cure mainly and the side in the contained main effective ingredient of each medicine and physicochemical property thereof further improve and the design novel form is: content is the Tibetan medicine soft capsule of suspendible body.
The present invention is when improving the Tibetan medicine drug quality, some new technologies, new technique, new adjuvant and new equipment used for reference and quoted, not only preparation stability, bioavailability can be improved, traditional Tibetan medicine is combined, for road has been opened up in the Tibetan medicine reasonable development with modern formulation method.
(1) Radix Inulae invigorating the spleen and regulating the stomach, promoting the flow of QI for relieving the stagnancy, analgesic function.Mainly contain volatile oil and contain the Coumarins composition.The Rhizoma Zingiberis cold expelling that induces sweat reduces phlegm and quenches the thirst, promoting flow of QI and blood.Mainly contain multiple volatile ingredient.Therefore Radix Inulae and Rhizoma Zingiberis are merged employing CO
2Supercritical extraction technique obtains volatile oil.
(2) XUANGOUMU heat-clearing and toxic substances removing, the plague fever molding.The XUANGOUMU platymiscium mainly contains compositions such as flavonoid, phenolic acids, tannin, vitamin (Vit.B, Vit.C), terpene, Quercetin methyl ether and sterols.Disorderly due to the Herba Lycopodii clearing heat and moistening lung, blending pathology.Mainly contain wide muscle alkali, 5-alkane propoxyl group-6,7,4-trimethoxy flavone, Herba Lycopodii are because of compositions such as ketone, Sitosterolum, tetracosanol, quercitols.So two medicines merge alcohol reflux.
(3) because of former side's usage is to be decocted in water for oral dose, so with Radix Inulae and Rhizoma Zingiberis CO
2Medicinal residues behind medicinal residues behind the supercritical extraction and XUANGOUMU and the Herba Lycopodii alcohol reflux merge decocting and boil, to keep the curative effect of clinical powder.
Description of drawings
Fig. 1 is a kind of process for producing four-Tibet inula root soft capsule process chart of the present invention.
The specific embodiment
Below in conjunction with drawings and Examples a kind of process for producing four-Tibet inula root soft capsule technical scheme of the present invention is further described.
As shown in Figure 1, a kind of four-Tibet inula root capsule is characterized in that described capsule made by the raw material of following weight parts: XUANGOUMU: Radix Inulae: Herba Lycopodii: Rhizoma Zingiberis=2: 1: 1: 0.5;
Its preparation technology:
1) be that Radix Inulae and Rhizoma Zingiberis medical material merge employing CO
2Supercritical extraction, getting extract is volatile oil, standby;
2) XUANGOUMU and Herba Lycopodii medical material alcohol reflux merge alcohol reflux liquid, reclaim ethanol, get alcohol-extracted extract, and be standby;
3) with Radix Inulae and Rhizoma Zingiberis CO
2Medicinal residues behind medicinal residues behind the supercritical extraction and XUANGOUMU and the Herba Lycopodii alcohol reflux decoct with water, and filter, and merge decoction liquor, and normal pressure concentrates, and get the water extracted immersing paste, and are standby;
4) merge the water extracted immersing paste and alcohol-extracted extract, the vacuum decompression drying, crushing screening gets water respectively and carries and the alcohol extraction dry extract, and is standby;
5) volatile oil, dry extract are joined in the substrate of diluent, suspending agent, wetting agent composition, stir, after further grinding, medicinal liquid is transferred in the liquid storage filling of encapsulating machine, regulate loading amount, be pressed into ball;
6) finalize the design, wash ball, be drying to obtain.
Described Radix Inulae and Rhizoma Zingiberis CO
2Supercritical extraction process is for after being broken into coarse powder with Radix Inulae, ginger powder, by Radix Inulae: Rhizoma Zingiberis=2:1 weight portion takes by weighing in the rearmounted 1L extraction kettle of mix homogeneously, extracting pressure is 20～35Mpa, extraction temperature is 30～50 ℃, extraction 1～3h, and the ethanol 150～300mL of adding 95% is as entrainer, get pale brown color ethanol liquid, decompression recycling ethanol through anhydrous sodium sulfate drying, must have the pale brown color volatile oil of special strong fragrance.
Described Radix Inulae and Rhizoma Zingiberis CO
2The supercritical extraction process condition is extracting pressure 35Mpa, 40 ℃ of extraction temperature, and 1 hour time, carrying dosage secretly is 225mL.
Described XUANGOUMU and the alcoholic acid extraction process of Herba Lycopodii medical material are by XUANGOUMU: Herba Lycopodii=2: 1 weight portions take by weighing the back and adopt alcohol reflux, and process conditions are determining alcohol 60～90%; 8～12 times of solvent amounts; 1～2 hour extraction time; Extraction time 1～3 time.
The alcoholic acid extraction process condition of described XUANGOUMU and Herba Lycopodii medical material is that determining alcohol is 75%; 8 times of solvent amounts; 1.5 hours extraction times; Extraction time 2 times.
Described reflux, extract, technology is in XUANGOUMU: Radix Inulae: Herba Lycopodii: Rhizoma Zingiberis=2: 1: 1: 0.5 ratio takes by weighing medicinal residues behind Radix Inulae and the Rhizoma Zingiberis CO2 supercritical extraction and the medicinal residues behind XUANGOUMU and the Herba Lycopodii medical material ethanol extraction, extracting in water, the decocting that adds 8～12 times of amounts boils, 1～2 hour extraction time, extraction time 1～3 time.
Described reflux, extract, technology is in XUANGOUMU: Radix Inulae: Herba Lycopodii: Rhizoma Zingiberis=2: 1: 1: 0.5 ratio takes by weighing medicinal residues behind Radix Inulae and the Rhizoma Zingiberis CO2 supercritical extraction and the medicinal residues behind XUANGOUMU and the Herba Lycopodii medical material ethanol extraction, the decocting that adds 12 times of amounts boils, 2 hours extraction times, extraction time 2 times.Filter, merge decoction liquor, normal pressure concentrates, and gets the water extracted immersing paste;
Merge the water extracted immersing paste and alcohol-extracted extract, 70 ℃ of vacuum dryings, crushing screening gets water respectively and carries and the alcohol extraction dry extract.
Described preparations shaping technology is that volatile oil and dry extract and diluent soybean oil are 1:1:2.0～2.5 mixed by weight, the adding weight percentage is 2.5% wetting agent soybean phospholipid, and the adding weight percentage is 4% suspending agent Cera Flava mixing for standby use; Softgel shell basis prescription is selected: softgel shell basis prescription adopts soft capsule gelatin, purified water, plasticizer prescription commonly used, and its ratio is a gelatin: water: plasticizer glycerol=1:1:0.4; Encapsulating machine sprinkler body pressing-in temp is 42 ℃～46 ℃; Soft capsule setting temperature routinely is to finalize the design under 20 ℃～60 ℃ temperature behind 2h～3h, is that 20 ℃～30 ℃ dry 10h～20h promptly get four-Tibet inula root soft capsule of the present invention with the rotating cage temperature.
Embodiment 1.
(1) get Radix Inulae 50 gram, Rhizoma Zingiberis 25 gram medical materials add entrainer ethanol 150ml, under extracting pressure 20Mpa, in 30 ℃ of extraction 2h.Collect CO
2Supercritical extraction liquid reclaims ethanol, gets volatile oil.
(2) XUANGOUMU 100 grams, Herba Lycopodii 50 gram medical materials add 60% ethanol of 10 times of amounts, reflux, extract, 1 time, each 1. hours.Filter, filtrate merges, and reclaims ethanol to there not being the alcohol flavor, is condensed into extractum.
(3) Radix Inulae, Rhizoma Zingiberis CO
2Medicinal residues after medicinal residues behind the supercritical extraction and XUANGOUMU, the Herba Lycopodii alcohol extraction add 8 times of water gagings and decoct 1 time, and each 1 hour, filter, collecting decoction is condensed into extractum.
(4) above-mentioned (2) and (3) extractum are merged, 70 ℃ of vacuum dryings get the dry extract powder.
(5) get with volatile oil and dry extract weight portion be that the soybean oil of 1:1:2.0 and weight percentage are 4% suspending agent Cera Flava mixing, being heated to about 70 ℃ fuses Cera Flava fully, put and be chilled to below 35 ℃, add volatile oil and wetting agent soybean phospholipid, be stirred to moltenly entirely, add dry extract, stir, grind evenly, evacuation cancellation bubble gets soft capsule capsule-core liquid.By the ratio glue sheet of expansible gelatin and glycerol behind the distilled water immersion in 1:0.4, be pressed into soft capsule through encapsulating machine, in 20 ℃ of dry about 10h, dry and comfortable to the soft gelatin capsule surface, hardness is suitable, promptly.
Embodiment 2.
(1) get Radix Inulae 50 gram, Rhizoma Zingiberis 25 gram medical materials add entrainer ethanol 225ml, under extracting pressure 35Mpa, in 40 ℃ of extraction 1h.Collect CO
2Supercritical extraction liquid reclaims ethanol, gets volatile oil.
(2) XUANGOUMU 100 grams, Herba Lycopodii 50 gram medical materials add 75% ethanol of 8 times of amounts, reflux, extract, 2 times, each 1.5 hours.Filter, filtrate merges, and reclaims ethanol to there not being the alcohol flavor, is condensed into extractum.
(3) Radix Inulae, Rhizoma Zingiberis CO
2Medicinal residues after medicinal residues behind the supercritical extraction and XUANGOUMU, the Herba Lycopodii alcohol extraction add 12 times of water gagings and decoct 2 times, and each 2 hours, filter, collecting decoction is condensed into extractum.
(4) above-mentioned (2) and (3) extractum are merged, 70 ℃ of vacuum dryings get the dry extract powder.
(5) be that the soybean oil of 1:1:2.2 and weight percentage are 4% suspending agent Cera Flava mixing with volatile oil and dry extract weight portion, being heated to about 80 ℃ fuses Cera Flava fully, put and be chilled to below 35 ℃, add volatile oil and soybean phospholipid, be stirred to moltenly entirely, add dry extract, stir, grind evenly, evacuation cancellation bubble gets soft capsule capsule-core liquid.By the ratio glue sheet of expansible gelatin and glycerol behind the distilled water immersion in 1:0.4, be pressed into soft capsule through encapsulating machine, dry and comfortable to the soft gelatin capsule surface in 28 ℃ of dry 16h, hardness is suitable, promptly.
Embodiment 3.
(1) get Radix Inulae 50 gram, Rhizoma Zingiberis 25 gram medical materials add entrainer ethanol 250ml, under extracting pressure 28Mpa, in 40 ℃ of extraction 3h.Collect CO
2Supercritical extraction liquid reclaims ethanol, gets volatile oil.
(2) XUANGOUMU 100 grams, Herba Lycopodii 50 gram medical materials add 90% ethanol of 12 times of amounts, reflux, extract, 3 times, each 3 hours.Filter, filtrate merges, and reclaims ethanol to there not being the alcohol flavor, is condensed into extractum.
(3) Radix Inulae, Rhizoma Zingiberis CO
2Medicinal residues after medicinal residues behind the supercritical extraction and XUANGOUMU, the Herba Lycopodii alcohol extraction add 12 times of water gagings and decoct 3 times, and each 1.5 hours, filter, collecting decoction is condensed into extractum.
(4) above-mentioned (2) and (3) extractum are merged, 70 ℃ of vacuum dryings get the dry extract powder.
(5) get with volatile oil and dry extract weight portion be that the soybean oil of 1:1:2.5 and weight percentage are 4% suspending agent Cera Flava mixing, being heated to about 85 ℃ fuses Cera Flava fully, put and be chilled to below 35 ℃, add volatile oil and soybean phospholipid, be stirred to moltenly entirely, add dry extract, stir, grind evenly, evacuation cancellation bubble gets soft capsule capsule-core liquid.By the ratio glue sheet of expansible gelatin and glycerol behind the distilled water immersion in 1:0.4, be pressed into soft capsule through encapsulating machine, dry and comfortable to the soft gelatin capsule surface in 30 ℃ of dry 20h, hardness is suitable, promptly.
Embodiment 4.
XUANGOUMU 3333g Radix Inulae 1667g Herba Lycopodii 1667g Rhizoma Zingiberis 833g
More than four flavors, get Radix Inulae, the Rhizoma Zingiberis medical material adds entrainer 300ml, under extracting pressure 35Mpa, in 40 ℃ of extraction 1h.Collect CO
2Supercritical extraction liquid reclaims ethanol, gets volatile oil.XUANGOUMU, Herba Lycopodii medical material add 75% ethanol of 8 times of amounts, reflux, extract, 2 times, each 1.5 hours.Filter, filtrate merges, and reclaims ethanol to there not being the alcohol flavor, is condensed into extractum.Radix Inulae, Rhizoma Zingiberis CO
2Medicinal residues after medicinal residues behind the supercritical extraction and XUANGOUMU, the Herba Lycopodii alcohol extraction add 12 times of water gagings and decoct 2 times, and each 2 hours, filter, collecting decoction is condensed into extractum.Two extractum are merged, and 70 ℃ of vacuum dryings get the dry extract powder.Get soybean oil 3000g and Cera Flava 60g mixing, be heated to about 80 ℃ Cera Flava is fused fully, put and be chilled to below 35 ℃, add volatile oil 94g and soybean phospholipid 37.5g, be stirred to moltenly entirely, add dry extract 1406g, stir, grind evenly, evacuation cancellation bubble gets soft capsule capsule-core liquid.By the ratio glue sheet of expansible gelatin and glycerol behind the distilled water immersion in 1:0.4, be pressed into soft capsule through encapsulating machine, in dry about 16h below 30 ℃, dry and comfortable to the soft gelatin capsule surface, hardness is suitable, makes 10000.Promptly.
Embodiment 5.
Preparation prescription: dry extract 1406g, volatile oil 94g, soybean oil 3000g, soybean phospholipid 37.5g, Cera Flava 60g, make 10000.
Preparation technology: get the soybean oil and the Cera Flava mixing of recipe quantity, be heated to about 80 ℃ Cera Flava is fused fully, put and be chilled to below 35 ℃, add volatile oil and soybean phospholipid, be stirred to moltenly entirely, add dry extract, stir, grind evenly, evacuation cancellation bubble gets soft capsule capsule-core liquid.By the ratio glue sheet of expansible gelatin and glycerol behind the distilled water immersion in 1:0.4, be pressed into soft capsule through encapsulating machine, in dry about 16h below 30 ℃, dry and comfortable to the soft gelatin capsule surface, hardness is suitable, promptly.
Claims (8)
1, a kind of process for producing four-Tibet inula root soft capsule is characterized in that described capsule made by the raw material of following weight parts: XUANGOUMU: Radix Inulae: Herba Lycopodii: Rhizoma Zingiberis=2: 1: 1: 0.5; Its preparation technology:
1) be that Radix Inulae and Rhizoma Zingiberis medical material merge employing CO
2Supercritical extraction, getting extract is volatile oil, standby;
2) XUANGOUMU and Herba Lycopodii medical material alcohol reflux merge alcohol reflux liquid, reclaim ethanol, get alcohol-extracted extract, and be standby;
3) with Radix Inulae and Rhizoma Zingiberis CO
2Medicinal residues behind medicinal residues behind the supercritical extraction and XUANGOUMU and the Herba Lycopodii alcohol reflux decoct with water, and filter, and merge decoction liquor, and normal pressure concentrates, and get the water extracted immersing paste, and are standby;
4) merge the water extracted immersing paste and alcohol-extracted extract, the reduced vacuum drying, crushing screening gets water and carries and the alcohol extraction dry extract, and is standby;
5) volatile oil, dry extract are joined in the substrate of diluent, suspending agent, wetting agent composition, stir, after further grinding, medicinal liquid is transferred in the liquid storage filling of encapsulating machine, regulate loading amount, be pressed into ball;
6) finalize the design, wash ball, be drying to obtain.
2, process for producing four-Tibet inula root soft capsule according to claim 1 is characterized in that: described Radix Inulae and Rhizoma Zingiberis CO
2Supercritical extraction process is for after being broken into coarse powder with Radix Inulae, ginger powder, by Radix Inulae: Rhizoma Zingiberis=weight portion took by weighing in the rearmounted 1L extraction kettle of mix homogeneously in 2: 1, extracting pressure is 20～35Mpa, extraction temperature is 30～50 ℃, extraction 1～3h, and the ethanol 150～300mL of adding 95% is as entrainer, get pale brown color ethanol liquid, decompression recycling ethanol through anhydrous sodium sulfate drying, must have the pale brown color volatile oil of special strong fragrance.
3, process for producing four-Tibet inula root soft capsule according to claim 1 and 2 is characterized in that: described Radix Inulae and Rhizoma Zingiberis CO
2The supercritical extraction process condition is extracting pressure 35Mpa, 40 ℃ of extraction temperature, and 1 hour time, carrying dosage secretly is 225mL.
4, process for producing four-Tibet inula root soft capsule according to claim 1 is characterized in that; Described XUANGOUMU and the alcoholic acid extraction process of Herba Lycopodii medical material are by XUANGOUMU: Herba Lycopodii=2: 1 weight portions take by weighing the back and adopt alcohol reflux, and process conditions are determining alcohol 60～90%; 8～12 times of solvent amounts; 1～2 hour extraction time; Extraction time 1～3 time.
5, process for producing four-Tibet inula root soft capsule according to claim 4 is characterized in that: the alcoholic acid extraction process condition of described XUANGOUMU and Herba Lycopodii medical material is that determining alcohol is 75%; 8 times of solvent amounts; 1.5 hours extraction times; Extraction time 2 times.
6, process for producing four-Tibet inula root soft capsule according to claim 1, it is characterized in that: described reflux, extract, technology is in XUANGOUMU: Radix Inulae: Herba Lycopodii: Rhizoma Zingiberis=2: 1: 1: 0.5 ratio takes by weighing medicinal residues behind Radix Inulae and the Rhizoma Zingiberis CO2 supercritical extraction and the medicinal residues behind XUANGOUMU and the Herba Lycopodii medical material ethanol extraction, extracting in water, the decocting that adds 8～12 times of amounts boils, 1～2 hour extraction time, extraction time 1～3 time.
7, according to claim 1 or 6 described process for producing four-Tibet inula root soft capsule, it is characterized in that: described reflux, extract, technology is in XUANGOUMU: Radix Inulae: Herba Lycopodii: Rhizoma Zingiberis=2: 1: 1: 0.5 ratio takes by weighing medicinal residues behind Radix Inulae and the Rhizoma Zingiberis CO2 supercritical extraction and the medicinal residues behind XUANGOUMU and the Herba Lycopodii medical material ethanol extraction, the decocting that adds 12 times of amounts boils, 2 hours extraction times, extraction time 2 times.
8, process for producing four-Tibet inula root soft capsule according to claim 1, it is characterized in that: described preparations shaping technology is for being 1: 1: 2.0～2.5 mixed by weight with volatile oil and dry extract and soybean oil, the adding weight percentage is 2.5% wetting agent soybean phospholipid, and the adding weight percentage is 4% suspending agent Cera Flava mixing for standby use; Softgel shell basis prescription is selected: softgel shell basis prescription adopts soft capsule gelatin, purified water, plasticizer prescription commonly used, and its ratio is a gelatin: water: plasticizer glycerol=1: 1: 0.4; Encapsulating machine sprinkler body pressing-in temp is 42 ℃～46 ℃; Soft capsule setting temperature routinely is to finalize the design under 20-60 ℃ the temperature behind 2h～3h, is 20 ℃～30 ℃ dry 10h～20h with the rotating cage temperature.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102908519A (en) * | 2012-09-26 | 2013-02-06 | 济南星懿医药技术有限公司 | Medicine for treating influenza as well as preparation method and quality detection method of preparation of medicine |
| CN103585307A (en) * | 2013-05-31 | 2014-02-19 | 多杰 | Tibetan-medicine three-component Tibet inula soup-granula composition and preparation process thereof |
| CN114344439A (en) * | 2022-01-26 | 2022-04-15 | 青海省藏医药研究院 | Tibetan medicine Manuo Tangguanxinning composition, granules thereof and preparation method thereof |
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2008
- 2008-12-17 CN CNA2008101479319A patent/CN101428134A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102908519A (en) * | 2012-09-26 | 2013-02-06 | 济南星懿医药技术有限公司 | Medicine for treating influenza as well as preparation method and quality detection method of preparation of medicine |
| CN102908519B (en) * | 2012-09-26 | 2015-11-25 | 同溢堂药业有限公司 | A kind ofly treat the medicine of influenza and the preparation method of preparation thereof and quality determining method |
| CN103585307A (en) * | 2013-05-31 | 2014-02-19 | 多杰 | Tibetan-medicine three-component Tibet inula soup-granula composition and preparation process thereof |
| CN114344439A (en) * | 2022-01-26 | 2022-04-15 | 青海省藏医药研究院 | Tibetan medicine Manuo Tangguanxinning composition, granules thereof and preparation method thereof |
| CN114344439B (en) * | 2022-01-26 | 2022-11-04 | 青海省藏医药研究院 | Tibetan medicine Manuo series Tangguanxinning composition, granules thereof and preparation method thereof |
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Open date: 20090513 |