CN1582977A - Medicine for clearing away heat and toxic material, relieving cough and asthma and reducing sputum - Google Patents
Medicine for clearing away heat and toxic material, relieving cough and asthma and reducing sputum Download PDFInfo
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- CN1582977A CN1582977A CN 03135634 CN03135634A CN1582977A CN 1582977 A CN1582977 A CN 1582977A CN 03135634 CN03135634 CN 03135634 CN 03135634 A CN03135634 A CN 03135634A CN 1582977 A CN1582977 A CN 1582977A
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- medicine
- leaf
- flos lonicerae
- relieving
- cough
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Abstract
A medicine in the form of softgel for antipyress, detoxication, relieving cough and asthma, and resolving phlegm is disclosed.
Description
Technical field
The medicine that the present invention relates to a kind of heat-clearing and toxic substances removing, cough-relieving, reduces phlegm, relievings asthma, particularly a kind of acute and chronic bronchitis of being used for the treatment of of Chinese herbal medicine extracting composition that contains, cold cough belongs to lung-heat syndrome person's medicine.
Background technology
Powerful cough-relieving medicine capsule is to be used for the treatment of acute and chronic bronchitis at present, and one of Chinese patent medicine commonly used of cold cough belongs to lung-heat syndrome person contains leaf of Flos Lonicerae maackii, Folium Rhododendri Daurici wet goods Chinese medicine in the prescription.Powerful cough-relieving medicine capsule pharmaceutical standard is recorded in Chinese traditional patent formulation preparation promulgated by the ministries or commissions of the Central Government (the 17).
Existing powerful cough-relieving medicine capsule is with Oleum Rhododendri Daurici and calcium carbonate mixing, again by dilution method and the leaf of Flos Lonicerae maackii dry powder mix homogeneously of progressively increasing, incapsulate promptly, be unfavorable for keeping volatile ingredient wherein, medicine stability is low, and disintegration time is slower, molten in vivo loosing slowly, bioavailability is low, needs water to swallow, and takes inconvenience.
Summary of the invention
The objective of the invention is to provides a kind of newtype drug that has the following advantages powerful cough-relieving soft capsule at the powerful cough-relieving medicine capsule of existing medicine shortcoming: be beneficial to and keep wherein volatile ingredient, medicine stability is good; Because soft capsule content is liquid, medicine enters in the body and directly is easier to absorb for liquid spreads, thereby the bioavailability height; The profile slyness is flexible, swallows after the saliva moistening conveniently, and is also very suitable to inflexible old man of swallowing act or child, and patient is willing to accept.
Solution of the present invention is that existing powerful cough-relieving medicine capsule is changed dosage form, makes soft capsule dosage form.Its preparation method may further comprise the steps:
(1) described prescription Chinese medicine leaf of Flos Lonicerae maackii is pulverized, made solvent, carry out percolation extraction or reflux, extract, or soak extraction with 0%～100% ethanol; Or with water boiling and extraction and ethanol precipitation; Collect extracting solution, and concentrated extracting solution, drying obtains the dry extract of leaf of Flos Lonicerae maackii;
(2) described concentrated extract and Oleum Rhododendri Daurici are joined in the appropriate liquid adjuvant, mix homogeneously obtains medicinal liquid; Auxiliary Liquid Material comprises Polyethylene Glycol or vegetable oil or glycerol or propylene glycol or intermediate fatty glyceride or isopropyl alcohol or organic acid etc.
(3) it is even to make thickness after the dissolvings such as employing gelatin and glycerol, distilled water, and translucent film adopts pressing to make soft capsule; Or to utilize gelatin and oily medicinal liquid be biphase, adopts dropping preparation method to make soft capsule, through whole ball, be drying to obtain.
The invention has the beneficial effects as follows: advantages such as have taking convenience, the bioavailability height is beneficial to absorption, is beneficial to the preservation volatile effective component, and medicine stability is good.
The specific embodiment
The present invention is described in further detail below in conjunction with the specific embodiment.
The present invention changes dosage form with the powerful cough-relieving medicine capsule of existing medicine, makes soft capsule dosage form.
Embodiment one
Leaf of Flos Lonicerae maackii in the described prescription is decocted with water secondary (being respectively 2,1 hours), and gradation filters, and merging filtrate left standstill 12 hours, filters, and gets the supernatant concentrating under reduced pressure and becomes thick paste, and vacuum drying is ground into fine powder, sieves; Merge with Oleum Rhododendri Daurici, it is joined in the vegetable oil, dispersed with stirring is even, obtains medicinal liquid to be processed; With described medicinal liquid pelleting in pellet processing machine, whole ball, oven dry is promptly.
Embodiment two
Chinese medicine leaf of Flos Lonicerae maackii in the described prescription is pulverized, carried out percolation with 75% ethanol and extract, collect extracting solution, and reclaim ethanol, concentrate drying gets dry extract; Dried cream powder is sieved after broken, pressed powder, merge with Oleum Rhododendri Daurici, it is joined in the vegetable oil, dispersed with stirring is even, obtains medicinal liquid to be processed; With described medicinal liquid pelleting in pellet processing machine, whole ball, oven dry is promptly.
Embodiment three
Chinese medicine leaf of Flos Lonicerae maackii in the described prescription is pulverized, carried out reflux, extract, with 20% ethanol, collect extracting solution, and reclaim ethanol, concentrate drying gets dry extract; Dried cream powder is sieved after broken, pressed powder, merge with Oleum Rhododendri Daurici, it is joined in the PEG400, dispersed with stirring is even, obtains medicinal liquid to be processed; With described medicinal liquid pelleting in pellet processing machine, whole ball, oven dry is promptly.
Embodiment four
Chinese medicine leaf of Flos Lonicerae maackii in the described prescription is pulverized, carried out reflux, extract, with 50% ethanol, collect extracting solution, and reclaim ethanol, concentrate drying gets dry extract; Dried cream powder is sieved after broken, pressed powder, merge with Oleum Rhododendri Daurici, it is joined in the vegetable oil, dispersed with stirring is even, obtains medicinal liquid to be processed; Under the condition that keeps 80 ± 2 ℃ of steady temperatures, it is biphase utilizing gelatin and oily medicinal liquid with described medicinal liquid, drips to make ball, through cooling off, being drying to obtain.
Embodiment five
Chinese medicine leaf of Flos Lonicerae maackii in the described prescription is pulverized, and water carries out reflux, extract,, collects extracting solution, and is concentrated, adds ethanol to 70% precipitation, filters, and supernatant reclaims ethanol, and concentrated, drying gets dry extract; Dried cream powder is sieved after broken, pressed powder, merge with Oleum Rhododendri Daurici, it is joined in the vegetable oil, dispersed with stirring is even, obtains medicinal liquid to be processed; With described medicinal liquid pelleting in pellet processing machine, whole ball, oven dry is promptly.
Claims (3)
1. heat-clearing and toxic substances removing, cough-relieving is reduced phlegm, and the medicine of relievining asthma contains leaf of Flos Lonicerae maackii, Folium Rhododendri Daurici wet goods Chinese medicine in the prescription, be the capsular dosage changing form of powerful cough-relieving medicine.It is characterized in that described medicine is made soft capsule dosage form.
2. medicine according to claim 1 is characterized in that its preparation method may further comprise the steps:
(1) described prescription Chinese medicine leaf of Flos Lonicerae maackii is pulverized,, make solvent with 0%～100% ethanol, carry out percolation extraction or reflux, extract, or soak extraction; Or with water boiling and extraction and ethanol precipitation; Collect extracting solution, and concentrated extracting solution, drying obtains the dry extract of leaf of Flos Lonicerae maackii;
(2) leaf of Flos Lonicerae maackii dry extract, Oleum Rhododendri Daurici are joined in the appropriate liquid adjuvant, mix homogeneously obtains medicinal liquid;
(3) adopt the system of dripping or pressing to make soft capsule.
3. medicine according to claim 2 is characterized in that Auxiliary Liquid Material described in the described method is Polyethylene Glycol or vegetable oil or glycerol or propylene glycol or intermediate fatty glyceride or isopropyl alcohol or organic acid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03135634 CN1582977A (en) | 2003-08-21 | 2003-08-21 | Medicine for clearing away heat and toxic material, relieving cough and asthma and reducing sputum |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03135634 CN1582977A (en) | 2003-08-21 | 2003-08-21 | Medicine for clearing away heat and toxic material, relieving cough and asthma and reducing sputum |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1582977A true CN1582977A (en) | 2005-02-23 |
Family
ID=34597180
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 03135634 Pending CN1582977A (en) | 2003-08-21 | 2003-08-21 | Medicine for clearing away heat and toxic material, relieving cough and asthma and reducing sputum |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1582977A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102846895A (en) * | 2012-08-30 | 2013-01-02 | 沈士成 | Traditional Chinese medicine decoction used for treating acute bronchitis caused by wind heat affecting lung |
-
2003
- 2003-08-21 CN CN 03135634 patent/CN1582977A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102846895A (en) * | 2012-08-30 | 2013-01-02 | 沈士成 | Traditional Chinese medicine decoction used for treating acute bronchitis caused by wind heat affecting lung |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |