CN1589826A - Medicine for settling cough and eliminating phlegm - Google Patents
Medicine for settling cough and eliminating phlegm Download PDFInfo
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- CN1589826A CN1589826A CN 03135672 CN03135672A CN1589826A CN 1589826 A CN1589826 A CN 1589826A CN 03135672 CN03135672 CN 03135672 CN 03135672 A CN03135672 A CN 03135672A CN 1589826 A CN1589826 A CN 1589826A
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- medicine
- extract
- soft capsule
- ethanol
- radix glycyrrhizae
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Abstract
A Chinese medicine in the form of capsule for treating cough and dispelling phlegm is disclosed, which is an improvement to existing several Chinese medicines.
Description
Technical field
The present invention relates to a kind of medicine of relieving cough and expelling phlegm, be particularly related to a kind of acute and chronic bronchitis of being used for the treatment of of Chinese herbal medicine extracting composition that contains, cold cough belongs to lung-heat syndrome person's medicine, Chinese medicinal soft capsule and the preparation technology thereof identical with the Zhendening Tangjiang material medicine.
Background technology
Zhendening Tangjiang is to be used for the treatment of the cough due to common cold at present, bronchitis, and one of Chinese patent medicine commonly used of asthma contains components such as Radix Glycyrrhizae fluidextract, Radix Platycodonis, ephedrine hydrochloride, Cortex Mori in the prescription.The Zhendening Tangjiang drug standard records in one one of Chinese Pharmacopoeia version in 2000.
Existing Zhendening Tangjiang is owing to contain ethanol in its preparation, mouthfeel is bad, zest is big, patient is difficult to accept, taking for a long time has damaging action to human body, especially child, anemia of pregnant woman, heart disease, hepatic injury and hyperpietic etc. more are difficult to be suitable for, and the sugar content height, it is short to grow microorganism, effect duration easily, forbids or patient's (as diabetics) of control sugar part intake also should not use for need.And solvent strength easily takes place in storage process change, the finished product color and luster and variations of tiring produce precipitation, problems such as abnormal smells from the patient change, and transport, carry equal inconvenience, shortcoming such as medicine stability is low.
Summary of the invention
The objective of the invention is at existing medicine Zhendening Tangjiang shortcoming, a kind of peaceful soft capsule of newtype drug antitussive that has the following advantages is provided: do not contain ethanol, do not contain sugar, medicine stability is good, and effect duration is long; Because soft capsule content is liquid, medicine enters in the body and directly is easier to absorb for liquid spreads, thereby the bioavailability height; The profile slyness is flexible, swallows after the saliva moistening conveniently, and also very suitable to the inflexible old man of swallowing act or child and diabetics, patient is willing to accept.
Solution of the present invention is that existing Zhendening Tangjiang is changed dosage form, makes soft capsule dosage form.Its preparation method may further comprise the steps:
(1) described prescription Chinese medicine Radix Platycodonis, Cortex Mori are pulverized, both merge or are soaked in water separately respectively and extract or use water boiling and extraction, collect extracting solution and concentrate, and add ethanol precipitation again, filter, and supernatant recovery ethanol obtains extract; Or make solvent with 0%-100% ethanol or ethyl acetate, and carry out percolation extraction or heating extraction or soak and extract, collect extracting solution, and reclaim solvent and obtain concentrated extract.
(2) described concentrated extract and Radix Glycyrrhizae fluidextract, ephedrine hydrochloride are joined in the appropriate liquid adjuvant, mix homogeneously obtains medicinal liquid; Auxiliary Liquid Material comprises Polyethylene Glycol or vegetable oil or glycerol or propylene glycol or intermediate fatty glyceride or isopropyl alcohol or organic acid etc.
(3) it is even to make thickness after the dissolvings such as employing gelatin and glycerol, distilled water, and translucent film adopts pressing to make soft capsule; Or to utilize gelatin and oily medicinal liquid be biphase, adopts dropping preparation method to make soft capsule, through whole ball, be drying to obtain.
The invention has the beneficial effects as follows: have taking convenience, the bioavailability height; Advantages such as be beneficial to absorption, medicine stability is good, and suitable patient is wide.
The specific embodiment
The present invention is described in further detail below in conjunction with the specific embodiment.
The present invention changes dosage form with existing medicine Zhendening Tangjiang, makes soft capsule dosage form.
Embodiment one
Radix Platycodonis and Cortex Mori in the described prescription are pulverized, and both respectively or merge and make solvent with 40% ethanol carry out percolation, collect the liquid of filtering, and reclaim ethanol, and are concentrated; Add Radix Glycyrrhizae fluidextract, ephedrine hydrochloride, mixing joins it in vegetable oil, and dispersed with stirring is even, obtains medicinal liquid to be processed; With described medicinal liquid pelleting in pellet processing machine, whole ball, oven dry is promptly.
Embodiment two
Chinese medicine Radix Platycodonis in the described prescription and Cortex Mori are pulverized, carried out percolation with 75% ethanol and extract, collect extracting solution, and reclaim ethanol, concentrate drying gets dry extract; Dried cream powder is sieved after broken, pressed powder, merge with Radix Glycyrrhizae fluidextract, ephedrine hydrochloride, it is joined in the vegetable oil, dispersed with stirring is even, obtains medicinal liquid to be processed; With described medicinal liquid pelleting in pellet processing machine, whole ball, oven dry is promptly.
Embodiment three
Chinese medicine Radix Platycodonis in the described prescription and Cortex Mori are pulverized, carried out reflux, extract, with ethyl acetate, collect extracting solution, and reclaim ethyl acetate, concentrate drying gets dry extract; Dried cream powder is sieved after broken, pressed powder, merge with Radix Glycyrrhizae fluidextract, ephedrine hydrochloride, it is joined in the PEG400, dispersed with stirring is even, obtains medicinal liquid to be processed; With described medicinal liquid pelleting in pellet processing machine, whole ball, oven dry is promptly.
Embodiment four
Chinese medicine Radix Platycodonis in the described prescription and Cortex Mori are pulverized, carried out reflux, extract, with 50% ethanol, collect extracting solution, and reclaim ethanol, concentrate drying gets dry extract; Dried cream powder is sieved after broken, pressed powder, merge with Radix Glycyrrhizae fluidextract, ephedrine hydrochloride, it is joined in the vegetable oil, dispersed with stirring is even, obtains medicinal liquid to be processed; Under the condition that keeps 80 ± 2 ℃ of steady temperatures, it is biphase utilizing gelatin and oily medicinal liquid with described medicinal liquid, drips to make ball, through cooling off, being drying to obtain.
Embodiment five
Chinese medicine Radix Platycodonis in the described prescription and Cortex Mori are pulverized, and water carries out reflux, extract,, collects extracting solution, and is concentrated, adds ethanol to 70% precipitation, filters, and supernatant reclaims ethanol, and concentrated, drying gets dry extract; Dried cream powder is sieved after broken, pressed powder, merge with Radix Glycyrrhizae fluidextract, ephedrine hydrochloride, it is joined in the vegetable oil, dispersed with stirring is even, obtains medicinal liquid to be processed; With described medicinal liquid pelleting in pellet processing machine, whole ball, oven dry is promptly.
Claims (4)
1. the medicine of a relieving cough and expelling phlegm contains components such as Radix Glycyrrhizae fluidextract, Radix Platycodonis, ephedrine hydrochloride, Cortex Mori in the prescription, is the dosage changing form of Zhendening Tangjiang.It is characterized in that described medicine is made soft capsule dosage form.
2. medicine according to claim 1 is characterized in that its preparation method may further comprise the steps:
(1) described prescription Chinese medicine Radix Platycodonis, Cortex Mori are pulverized, both merge or are soaked in water separately respectively and extract or use water boiling and extraction, collect extracting solution and concentrate, and add ethanol precipitation again, filter, and supernatant recovery ethanol and concentrate drying obtain extract.
(2) said extracted thing, Radix Glycyrrhizae fluidextract, ephedrine hydrochloride are joined in the appropriate liquid adjuvant, mix homogeneously obtains medicinal liquid;
(3) adopt the system of dripping or pressing to make soft capsule.
3. medicine according to claim 1 is characterized in that its preparation method may further comprise the steps:
(1) makes solvent with 0%-100% ethanol or ethyl acetate, carry out percolation extraction or heating extraction or soak to extract, collect extracting solution, and reclaim solvent and concentrate drying obtains extract.
(2) said extracted thing, Radix Glycyrrhizae fluidextract, ephedrine hydrochloride are joined in the appropriate liquid adjuvant, mix homogeneously obtains medicinal liquid;
(3) adopt the system of dripping or pressing to make soft capsule.
4. according to claim 2,3 described medicines, it is characterized in that Auxiliary Liquid Material described in the described method is Polyethylene Glycol or vegetable oil or glycerol or propylene glycol or intermediate fatty glyceride or isopropyl alcohol or organic acid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03135672 CN1589826A (en) | 2003-08-27 | 2003-08-27 | Medicine for settling cough and eliminating phlegm |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03135672 CN1589826A (en) | 2003-08-27 | 2003-08-27 | Medicine for settling cough and eliminating phlegm |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1589826A true CN1589826A (en) | 2005-03-09 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 03135672 Pending CN1589826A (en) | 2003-08-27 | 2003-08-27 | Medicine for settling cough and eliminating phlegm |
Country Status (1)
| Country | Link |
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| CN (1) | CN1589826A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104739942A (en) * | 2015-04-10 | 2015-07-01 | 韩彩敏 | Traditional Chinese medicine for treating acute bronchitis |
| CN104906434A (en) * | 2015-07-01 | 2015-09-16 | 王艳红 | Cough expelling and phlegm reduction drink for treating chronic bronchitis and preparation method of cough expelling and phlegm reduction drink |
-
2003
- 2003-08-27 CN CN 03135672 patent/CN1589826A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104739942A (en) * | 2015-04-10 | 2015-07-01 | 韩彩敏 | Traditional Chinese medicine for treating acute bronchitis |
| CN104739942B (en) * | 2015-04-10 | 2017-12-19 | 亳州市永刚饮片厂有限公司 | A kind of Chinese medicine for treating acute bronchitis |
| CN104906434A (en) * | 2015-07-01 | 2015-09-16 | 王艳红 | Cough expelling and phlegm reduction drink for treating chronic bronchitis and preparation method of cough expelling and phlegm reduction drink |
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| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |