CN101703691A - Chinese medicinal composition for treating gastrointestinal ulcer and hemorrhage, and preparation method thereof - Google Patents
Chinese medicinal composition for treating gastrointestinal ulcer and hemorrhage, and preparation method thereof Download PDFInfo
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- CN101703691A CN101703691A CN200910024372A CN200910024372A CN101703691A CN 101703691 A CN101703691 A CN 101703691A CN 200910024372 A CN200910024372 A CN 200910024372A CN 200910024372 A CN200910024372 A CN 200910024372A CN 101703691 A CN101703691 A CN 101703691A
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Abstract
The invention relates to a Chinese medicinal composition for treating gastrointestinal ulcer and hemorrhage, which comprises the following raw materials in part by weight: 80 to 120 parts of rhubarb, 70 to 100 parts of golden thread, 70 to 100 parts of sanchi, 50 to 90 parts of dahurian angelica root, 30 to 60 parts of dragon's blood, 60 to 90 parts of common bletilla pseudobulb, 60 to 90 parts of cuttlebone, 15 to 30 parts of liquoric root, 5 to 15 parts of pearl and 5 to 10 parts of borneol. A preparation method of the Chinese medicinal composition comprises the following steps: crushing the rhubarb, the golden thread, the dahurian angelica root and the liquoric root into coarse powder, adding ethanol into the coarse powder, and decocting and filtrating the mixture to prepare clear ointment; uniformly mixing dregs of a decoction with common bletilla pseudobulb, adding water into the mixture for decoction, mixing decoction with the clear ointment, concentrating the mixture and drying the concentrated mixture to prepare medicinal powder; crushing the pearl and the cuttlebone into fine powder, and crushing the dragon's blood independently; mixing the medicinal powder uniformly, and adding the ethanol into the medicinal powder to prepare soft materials; and granulating the soft materials by using a granulator and drying the grains in a drying room, adding the borneol into the grains, uniformly mixing the mixture, and filling the mixture into capsules. The Chinese medicinal composition has the advantages of good curative effect, and no toxic or side effect, and the preparation method has the advantage of low preparation cost.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to a kind of digestive tract ulcer, hemorrhage Chinese medicine composition and preparation method thereof for the treatment of.
Background technology
Digestive tract ulcer, hemorrhage be a kind of commonly encountered diseases, frequently-occurring disease, the formation and development of Peptic Ulcers is relevant with the pepsin digestion effect with the gastric acid in Nervous and Mental Factors, helicobacter pylori and the gastric juice, be because interior diseases caused by exogenous pathogenic factor pathogen mostly, or internal injury diet, feelings will are unsuccessful, depression of liver-QI, cut down the gas that injures one's stomach, stagnated QI transforming into fire impairment of YIN, the damage channels, and cause mucosa hyperemia, edema forms inflammation, then form ulcer for a long time, in addition hemorrhage.Digestive tract ulcer, the hemorrhage categories such as gastric abscess, acid regurgitation that belong in theory of Chinese medical science, its pathology belong to the stagnation of QI, blood stagnation, deficiency and coldness, several aspects such as hot and suffocating more, are stagnation of QI and blood may bring about pain in a word.And adopt western medicine to have treatment cost height in the present medicine, problems such as certain side effect are arranged.
The patent No. is ZL200510096362.6, denomination of invention is a kind of medicine for the treatment of metrorrhagia, hematemesis and having blood in stool, patent of invention discloses a kind of extraction and capsule preparation method thereof for the treatment of metrorrhagia, hematemesis and the medicine of having blood in stool and capsule prescription and active ingredient, prescription 14 flavor medical materials, therapeutic effect is poor, and it is big that the patient bears economic pressures.
Summary of the invention
In order to overcome the shortcoming of above-mentioned prior art, the object of the present invention is to provide a kind of digestive tract ulcer, hemorrhage Chinese medicine composition and preparation method thereof for the treatment of, this medical instrument is effective in cure good, and the advantage that has no side effect, and this method has advantage cheap for manufacturing cost.
In order to achieve the above object, the technical solution used in the present invention is:
A kind of digestive tract ulcer, hemorrhage Chinese medicine composition for the treatment of, its raw material weight component comprises:
Radix Et Rhizoma Rhei 80-120 part, Rhizoma Coptidis 70-100 part, Radix Notoginseng 70-100 part, Radix Angelicae Dahuricae 50-90 part, Sanguis Draxonis 30-60 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 60-90 part, Endoconcha Sepiae 60-90 part, Radix Glycyrrhizae 15-30 part, Margarita 5-15 part and Borneolum Syntheticum 5-10 part.
A kind of digestive tract ulcer, hemorrhage Chinese medicine composition for the treatment of, its raw material weight component is:
Radix Et Rhizoma Rhei 80-120 part, Rhizoma Coptidis 70-100 part, Radix Notoginseng 70-100 part, Radix Angelicae Dahuricae 50-90 part, Sanguis Draxonis 30-60 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 60-90 part, Endoconcha Sepiae 60-90 part, Radix Glycyrrhizae 15-30 part, Margarita 5-15 part and Borneolum Syntheticum 5-10 part.
A kind of digestive tract ulcer, hemorrhage Chinese medicine composition for the treatment of, its raw material weight component comprises:
Radix Et Rhizoma Rhei 90-110 part, Rhizoma Coptidis 80-90 part, Radix Notoginseng 80-90 part, Radix Angelicae Dahuricae 65-75 part, Sanguis Draxonis 40-50 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 70-80 part, Endoconcha Sepiae 70-80 part, Radix Glycyrrhizae 20-30 part, Margarita 10-15 part and Borneolum Syntheticum 5-10 part.
A kind of digestive tract ulcer, hemorrhage Chinese medicine composition for the treatment of, its raw material weight component is:
Radix Et Rhizoma Rhei 90-110 part, Rhizoma Coptidis 80-90 part, Radix Notoginseng 80-90 part, Radix Angelicae Dahuricae 65-75 part, Sanguis Draxonis 40-50 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 70-80 part, Endoconcha Sepiae 70-80 part, Radix Glycyrrhizae 20-30 part, Margarita 10-15 part and Borneolum Syntheticum 5-10 part.
A kind of preparation method for the treatment of digestive tract ulcer, hemorrhage Chinese medicine composition comprises the following steps:
The first step, 80～120 parts of Radix Et Rhizoma Rhei, 70～100 parts of Rhizoma Coptidis, 70～100 parts of Radix Notoginseng, 50～90 parts of the Radixs Angelicae Dahuricae and Radix Glycyrrhizae are ground into 18～30 order coarse powder for 15～30 parts, add 60～90% ethanol of 4～6 times of amounts of above-mentioned five kinds of medicine gross weights, be heated to 75～90 ℃ of backflow secondaries, each 1～3 hour, pour out decoction liquor, repeat above decoction process again, pour out decoction liquor, merge decoction liquor twice, filter, it is standby that recovery ethanol is made clear paste
Second step, to add the water of 8～12 times of amounts of medicine weight behind the medicinal residues in the first step and 60～90 part of 20 purpose Pseudobulbus Bletillae (Rhizoma Bletillae) coarse powder mix homogeneously, be heated to 90 ℃～100 ℃ and decoct twice, each 1～3 hour, merge decoction liquor twice, filter with 200 order stainless steel meshs, mix, be condensed into relative density in 60～80 ℃ and be determined as 1.35～1.38 thick paste at 60 ℃ with the clear paste that the first step is made, be dried to dried cream in 60 ℃～80 ℃, pulverized 80 eye mesh screens, it is standby to make medicated powder
The 3rd step was ground into fine powder for 60～90 parts with 5～15 parts of Margaritas, Endoconcha Sepiae, and the fineness of Margarita, Endoconcha Sepiae is 300 orders, and is standby,
The 4th step; 30～60 parts of Sanguis Draxonis are ground into 60-100 order fine powder separately,, add 75～95% ethanol that account for mixed powder weight 10～30% and mix with the second step gained medicated powder, the 3rd step gained medicated powder mix homogeneously; make soft material; in granulator, granulate, in hothouse,, cross 20 mesh sieves with 60～80 ℃ temperature drying 1～2 hour with 20 eye mesh screens; add 5～10 parts of 60 purpose Borneolum Syntheticums again; mix homogeneously is filled to capsule, promptly.
To pathogenetic research of Peptic Ulcers and Therapeutic Principle thereof, simultaneously according to the pharmaceutical research achievement, filter out that function cures mainly is the clearing away heat and cooling blood hemostasis to the present composition, the blood stasis dispelling promoting granulation and relieving pain based on medical science.It is hemorrhage to be used for digestive tract ulcer, is equivalent to the heat in blood blood stasis type hematemesis of motherland's medical science, the natural plant of the category of having blood in stool, and according to the theory of Chinese medical science prescription, is prepared from according to certain weight proportion.
Radix Et Rhizoma Rhei, Rhizoma Coptidis in the side, clearing away heat and cooling blood stops blooding, blood stasis-eliminating and stagnation-dissipating is capable stagnates, and is monarch drug altogether; The former bitter cold is returned spleen, stomach, large intestine channel, gets the property of its bitter cold sedimentation, lets out with preventing or arresting vomiting blood below making inflammation fiery; The energy of desirable again its blood circulation promoting and blood stasis dispelling, the blood stasis place is long-pending to control, fresh blood is not given birth to, hemorrhage all cards of escape of blood from meridian.As ancients' cloud: Radix Et Rhizoma Rhei can be gone into blood system, removing blood stasis with potent drugs blood, and it is descending to draw gastric qi, so kind preventing or arresting vomiting blood ".And also nature and flavor bitter cold of Rhizoma Coptidis, GUIXIN, stomach, large intestine channel, the special eliminating fire and detoxication of merit, heat clearing away are hot-tempered wet.Both can be used for the haematemesis due to intenseness of heat heated, the absurd row of forcing blood, can be used for all cards of having blood in stool, suffer from abdominal pain due to the intestines and stomach damp-heat accumulation again, be harmonious and usefulness, be the master in the side altogether with Radix Et Rhizoma Rhei.And ministerial drug in the Radix Notoginseng, Sanguis Draxonis, the Radix Angelicae Dahuricae side of being, wherein the little hardship of Radix Notoginseng is gone into the stomach warp, removing stasis to stop bleeding, and hemostasis is arranged and do not stay the characteristic of the stasis of blood; Sanguis Draxonis is sweet salty, and the salty in the mouth person specially goes into blood system, but promoting blood circulation to remove blood stasis pain relieving for oral administration hemostasis also arranged and do not stay the magical effect of the stasis of blood, it is hot-tempered wet that the Radix Angelicae Dahuricae dispels the wind, detumescence and apocenosis, pain relieving, the person that bursts can loose in energy dissipating, the person that bursts can the evacuation of pus pain relieving; And Endoconcha Sepiae, Pseudobulbus Bletillae (Rhizoma Bletillae), Margarita, the genus of Borneolum Syntheticum is the adjuvant drug in the side.The Endoconcha Sepiae astringing to arrest bleeding with the Radix Angelicae Dahuricae, the same usefulness of Borneolum Syntheticum, can be controlled the many pus of ulcer; The Pseudobulbus Bletillae (Rhizoma Bletillae) astringing to arrest bleeding, detumescence and promoting granulation; Margarita, Borneolum Syntheticum clearing away heat to alleviate pain are controlled ulcer not closing in for a long time person and are imitated Zhuo.Four medicines are harmonious, and assistant helps the monarch and his subjects to strengthen the effect of hemostasis first, doublely first control haematemesis, have blood in stool and accompany ulcer pain.As for the messenger drug in the Radix Glycyrrhizae side of being, Radix Glycyrrhizae is sweet flat, goes into the taste warp, relieving spasm to stop pain arranged, relax the property of medicine, priming return through merit, Radix Glycyrrhizae and Radix Et Rhizoma Rhei match, and can relax its discharge function again.As " medication on the analogy of natural things " cloud: " Radix Glycyrrhizae ... its performance emergency and all medicines of coordinating makes it out of question, so slow its heat that the medicine of a warm nature gets, cold medicine gets, and slow it is cold." we's totally ten flavors, monarch matches, the product of the thing of clearing away heat and cooling blood hemostasis and blood-activating analgetic convergence mutually 5, and Each performs its own functions, complements each other again.Full side pays attention to hemostasis and does not stay the stasis of blood, blood stasis dispelling and motionless blood, but receiving both clearing away heat and cooling blood hemostasis, but the merit of blood stasis dispelling promoting granulation and relieving pain again in order to the hematemesis due to the treatment heat in blood blood stasis, have blood in stool, can make that its pyretic toxicity is clear, blood stasisization, QI and blood transfer, its pain must, its hemorrhage must ending.
The specific embodiment
Below by specific embodiment the present invention is further described.
Embodiment 1
A kind of digestive tract ulcer, hemorrhage Chinese medicine composition for the treatment of, its raw material weight component comprises: 5 parts of 80 parts of Radix Et Rhizoma Rhei, 75 parts of Rhizoma Coptidis, 75 parts of Radix Notoginseng, 55 parts of the Radixs Angelicae Dahuricae, 35 parts of Sanguis Draxonis, 65 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 65 parts of Endoconcha Sepiaes, 15 parts in Radix Glycyrrhizae, 5 parts of Margaritas and Borneolum Syntheticums.
A kind of digestive tract ulcer, hemorrhage Chinese medicine composition for the treatment of, its raw material weight component is: 5 parts of 80 parts of Radix Et Rhizoma Rhei, 75 parts of Rhizoma Coptidis, 75 parts of Radix Notoginseng, 55 parts of the Radixs Angelicae Dahuricae, 35 parts of Sanguis Draxonis, 65 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 65 parts of Endoconcha Sepiaes, 15 parts in Radix Glycyrrhizae, 5 parts of Margaritas and Borneolum Syntheticums.
A kind of preparation method for the treatment of digestive tract ulcer, hemorrhage Chinese medicine composition comprises the following steps:
The first step, 80 parts of Radix Et Rhizoma Rhei, 75 parts of Rhizoma Coptidis, 75 parts of Radix Notoginseng, 55 parts of the Radixs Angelicae Dahuricae and Radix Glycyrrhizae are ground into 20 order coarse powder for 15 parts, add 70% ethanol of 4 times of amounts of above-mentioned five kinds of medicine gross weights, be heated to 80 ℃ of backflow secondaries, each 1.5 hours, pour out decoction liquor, repeat above decoction process again, pour out decoction liquor, merge decoction liquor twice, filter, it is standby that recovery ethanol is made clear paste
Second step, with adding the water of 8 times of amounts of medicine weight behind 20 whitish eye of the medicinal residues in the first step and 65 parts and the coarse powder mix homogeneously, be heated to 90 ℃ and decoct twice, each 3 hours, merge decoction liquor twice, filter with 200 order stainless steel meshs, mix, be condensed into relative density in 70 ℃ and be determined as 1.36 thick paste at 60 ℃ with the clear paste that the first step is made, be dried to dried cream in 65 ℃, pulverized 80 eye mesh screens, it is standby to make medicated powder
The 3rd step was ground into fine powder for 65 parts with 5 parts of Margaritas, Endoconcha Sepiae, and the fineness of Margarita, Endoconcha Sepiae is 300 orders, and is standby,
The 4th step; 35 parts of Sanguis Draxonis are ground into 60 order fine powders separately,, add 75% ethanol that accounts for mixed powder weight 15% and mix with the second step gained medicated powder, the 3rd step gained medicated powder mix homogeneously; make soft material; in granulator, granulate, in hothouse,, cross 20 mesh sieves with 70 ℃ temperature drying 1.5 hours with 20 eye mesh screens; add 5 parts of 60 purpose Borneolum Syntheticums again; mix homogeneously is filled to capsule, promptly.
Embodiment 2
A kind of digestive tract ulcer, hemorrhage Chinese medicine composition for the treatment of, its raw material weight component comprises:
6 parts of 85 parts of Radix Et Rhizoma Rhei, 80 parts of Rhizoma Coptidis, 75 parts of Radix Notoginseng, 60 parts of the Radixs Angelicae Dahuricae, 30 parts of Sanguis Draxonis, 70 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 60 parts of Endoconcha Sepiaes, 18 parts in Radix Glycyrrhizae, 8 parts of Margaritas and Borneolum Syntheticums.
A kind of digestive tract ulcer, hemorrhage Chinese medicine composition for the treatment of, its raw material weight component is:
6 parts of 85 parts of Radix Et Rhizoma Rhei, 80 parts of Rhizoma Coptidis, 75 parts of Radix Notoginseng, 60 parts of the Radixs Angelicae Dahuricae, 30 parts of Sanguis Draxonis, 70 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 60 parts of Endoconcha Sepiaes, 18 parts in Radix Glycyrrhizae, 8 parts of Margaritas and Borneolum Syntheticums.
A kind of preparation method for the treatment of digestive tract ulcer, hemorrhage Chinese medicine composition comprises the following steps:
The first step, 85 parts of Radix Et Rhizoma Rhei, 80 parts of Rhizoma Coptidis, 75 parts of Radix Notoginseng, 60 parts of the Radixs Angelicae Dahuricae and Radix Glycyrrhizae are ground into 20 order coarse powder for 18 parts, add 65% ethanol of 5 times of amounts of above-mentioned five kinds of medicine gross weights, be heated to 80 ℃ of backflow secondaries, each 2 hours, pour out decoction liquor, repeat above decoction process again, pour out decoction liquor, merge decoction liquor twice, filter, it is standby that recovery ethanol is made clear paste
Second step, with adding the water of 10 times of amounts of medicine weight behind 20 whitish eye of the medicinal residues in the first step and 70 parts and the coarse powder mix homogeneously, be heated to 95 ℃ and decoct twice, each 2 hours, merge decoction liquor twice, filter with 200 order stainless steel meshs, mix, be condensed into relative density in 60 ℃ and be determined as 1.35 thick paste at 60 ℃ with the clear paste that the first step is made, be dried to dried cream in 70 ℃, pulverized 80 eye mesh screens, it is standby to make medicated powder
The 3rd step was ground into fine powder for 60 parts with 8 parts of Margaritas, Endoconcha Sepiae, and the fineness of Margarita, Endoconcha Sepiae is 300 orders, and is standby,
The 4th step; 30 parts of Sanguis Draxonis are ground into 60 order fine powders separately,, add 95% ethanol that accounts for mixed powder weight 15% and mix with the second step gained medicated powder, the 3rd step gained medicated powder mix homogeneously; make soft material; in granulator, granulate, in hothouse,, cross 20 mesh sieves with 60 ℃ temperature drying 2 hours with 20 eye mesh screens; add 6 parts of 60 purpose Borneolum Syntheticums again; mix homogeneously is filled to capsule, promptly.
Embodiment 3
A kind of digestive tract ulcer, hemorrhage Chinese medicine composition for the treatment of, its raw material weight component comprises: 9 parts of 100 parts of Radix Et Rhizoma Rhei, 85 parts of Rhizoma Coptidis, 85 parts of Radix Notoginseng, 70 parts of the Radixs Angelicae Dahuricae, 45 parts of Sanguis Draxonis, 75 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 75 parts of Endoconcha Sepiaes, 25 parts in Radix Glycyrrhizae, 14 parts of Margaritas and Borneolum Syntheticums.
A kind of digestive tract ulcer, hemorrhage Chinese medicine composition for the treatment of, its raw material weight component is: 9 parts of 100 parts of Radix Et Rhizoma Rhei, 85 parts of Rhizoma Coptidis, 85 parts of Radix Notoginseng, 70 parts of the Radixs Angelicae Dahuricae, 45 parts of Sanguis Draxonis, 75 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 75 parts of Endoconcha Sepiaes, 25 parts in Radix Glycyrrhizae, 14 parts of Margaritas and Borneolum Syntheticums.
A kind of preparation method for the treatment of digestive tract ulcer, hemorrhage Chinese medicine composition comprises the following steps:
The first step, 100 parts of Radix Et Rhizoma Rhei, 85 parts of Rhizoma Coptidis, 85 parts of Radix Notoginseng, 70 parts of the Radixs Angelicae Dahuricae and Radix Glycyrrhizae are ground into 20 order coarse powder for 25 parts, add 72% ethanol of 6 times of amounts of above-mentioned five kinds of medicine gross weights, be heated to 80 ℃ of backflow secondaries, each 2.5 hours, pour out decoction liquor, repeat above decoction process again, pour out decoction liquor, merge decoction liquor twice, filter, it is standby that recovery ethanol is made clear paste
Second step, with adding the water of 9 times of amounts of medicine weight behind 20 whitish eye of the medicinal residues in the first step and 75 parts and the coarse powder mix homogeneously, be heated to 92 ℃ and decoct twice, each 2.5 hours, merge decoction liquor twice, filter with 200 order stainless steel meshs, mix, be condensed into relative density in 75 ℃ and be determined as 1.37 thick paste at 60 ℃ with the clear paste that the first step is made, be dried to dried cream in 80 ℃, pulverized 80 eye mesh screens, it is standby to make medicated powder
The 3rd step was ground into fine powder for 75 parts with 14 parts of Margaritas, Endoconcha Sepiae, and the fineness of Margarita, Endoconcha Sepiae is 300 orders, and is standby,
The 4th step; 45 parts of Sanguis Draxonis are ground into 60 order fine powders separately,, add 90% ethanol that accounts for mixed powder weight 20% and mix with the second step gained medicated powder, the 3rd step gained medicated powder mix homogeneously; make soft material; in granulator, granulate, in hothouse,, cross 20 mesh sieves with 80 ℃ temperature drying 1 hour with 20 eye mesh screens; add 9 parts of 60 purpose Borneolum Syntheticums again; mix homogeneously is filled to capsule, promptly.
Embodiment 4
A kind of digestive tract ulcer, hemorrhage Chinese medicine composition for the treatment of, its raw material weight component comprises: 9 parts of 110 parts of Radix Et Rhizoma Rhei, 100 parts of Rhizoma Coptidis, 95 parts of Radix Notoginseng, 80 parts of the Radixs Angelicae Dahuricae, 60 parts of Sanguis Draxonis, 85 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 80 parts of Endoconcha Sepiaes, 30 parts in Radix Glycyrrhizae, 14 parts of Margaritas and Borneolum Syntheticums.
A kind of digestive tract ulcer, hemorrhage Chinese medicine composition for the treatment of, its raw material weight component is: 9 parts of 110 parts of Radix Et Rhizoma Rhei, 100 parts of Rhizoma Coptidis, 95 parts of Radix Notoginseng, 80 parts of the Radixs Angelicae Dahuricae, 60 parts of Sanguis Draxonis, 85 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 80 parts of Endoconcha Sepiaes, 30 parts in Radix Glycyrrhizae, 14 parts of Margaritas and Borneolum Syntheticums.
A kind of preparation method for the treatment of digestive tract ulcer, hemorrhage Chinese medicine composition comprises the following steps:
The first step, 110 parts of Radix Et Rhizoma Rhei, 100 parts of Rhizoma Coptidis, 95 parts of Radix Notoginseng, 80 parts of the Radixs Angelicae Dahuricae and Radix Glycyrrhizae are ground into 20 order coarse powder for 30 parts, add 75% ethanol of 5 times of amounts of above-mentioned five kinds of medicine gross weights, be heated to 78 ℃ of backflow secondaries, each 1.5 hours, pour out decoction liquor, repeat above decoction process again, pour out decoction liquor, merge decoction liquor twice, filter, it is standby that recovery ethanol is made clear paste
Second step, with adding the water of 12 times of amounts of medicine weight behind 20 whitish eye of the medicinal residues in the first step and 85 parts and the coarse powder mix homogeneously, be heated to 96 ℃ and decoct twice, each 2 hours, merge decoction liquor twice, filter with 200 order stainless steel meshs, mix, be condensed into relative density in 76 ℃ and be determined as 1.38 thick paste at 60 ℃ with the clear paste that the first step is made, be dried to dried cream in 80 ℃, pulverized 80 eye mesh screens, it is standby to make medicated powder
The 3rd step was ground into fine powder for 80 parts with 14 parts of Margaritas, Endoconcha Sepiae, and the fineness of Margarita, Endoconcha Sepiae is 300 orders, and is standby,
The 4th step; 60 parts of Sanguis Draxonis are ground into 60 order fine powders separately,, add 88% ethanol that accounts for mixed powder weight 30% and mix with the second step gained medicated powder, the 3rd step gained medicated powder mix homogeneously; make soft material; in granulator, granulate, in hothouse,, cross 20 mesh sieves with 78 ℃ temperature drying 1.5 hours with 20 eye mesh screens; add 9 parts of 60 purpose Borneolum Syntheticums again; mix homogeneously is filled to capsule, promptly.
Embodiment 5
A kind of digestive tract ulcer, hemorrhage Chinese medicine composition for the treatment of, its raw material weight component comprises: 7 parts of 105 parts of Radix Et Rhizoma Rhei, 85 parts of Rhizoma Coptidis, 85 parts of Radix Notoginseng, 75 parts of the Radixs Angelicae Dahuricae, 40 parts of Sanguis Draxonis, 70 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 70 parts of Endoconcha Sepiaes, 22 parts in Radix Glycyrrhizae, 12 parts of Margaritas and Borneolum Syntheticums.
A kind of digestive tract ulcer, hemorrhage Chinese medicine composition for the treatment of, its raw material weight component is: 7 parts of 105 parts of Radix Et Rhizoma Rhei, 85 parts of Rhizoma Coptidis, 85 parts of Radix Notoginseng, 75 parts of the Radixs Angelicae Dahuricae, 40 parts of Sanguis Draxonis, 70 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 70 parts of Endoconcha Sepiaes, 22 parts in Radix Glycyrrhizae, 12 parts of Margaritas and Borneolum Syntheticums.
A kind of preparation method for the treatment of digestive tract ulcer, hemorrhage Chinese medicine composition comprises the following steps:
The first step, 105 parts of Radix Et Rhizoma Rhei, 85 parts of Rhizoma Coptidis, 85 parts of Radix Notoginseng, 75 parts of the Radixs Angelicae Dahuricae and Radix Glycyrrhizae are ground into 20 order coarse powder for 22 parts, add 83% ethanol of 6 times of amounts of above-mentioned five kinds of medicine gross weights, be heated to 86 ℃ of backflow secondaries, each 2 hours, pour out decoction liquor, repeat above decoction process again, pour out decoction liquor, merge decoction liquor twice, filter, it is standby that recovery ethanol is made clear paste
Second step, with adding the water of 11 times of amounts of medicine weight behind 20 whitish eye of the medicinal residues in the first step and 70 parts and the coarse powder mix homogeneously, be heated to 95 ℃ and decoct twice, each 3 hours, merge decoction liquor twice, filter with 200 order stainless steel meshs, mix, be condensed into relative density in 77 ℃ and be determined as 1.36 thick paste at 60 ℃ with the clear paste that the first step is made, be dried to dried cream in 78 ℃, pulverized 80 eye mesh screens, it is standby to make medicated powder
The 3rd step was ground into fine powder for 70 parts with 12 parts of Margaritas, Endoconcha Sepiae, and the fineness of Margarita, Endoconcha Sepiae is 300 orders, and is standby,
The 4th step; 40 parts of Sanguis Draxonis are ground into 60 order fine powders separately,, add 85% ethanol that accounts for mixed powder weight 30% and mix with the second step gained medicated powder, the 3rd step gained medicated powder mix homogeneously; make soft material; in granulator, granulate, in hothouse,, cross 20 mesh sieves with 60 ℃ temperature drying 2 hours with 20 eye mesh screens; add 7 parts of 60 purpose Borneolum Syntheticums again; mix homogeneously is filled to capsule, promptly.
Embodiment 6
A kind of digestive tract ulcer, hemorrhage Chinese medicine composition for the treatment of, its raw material weight component comprises: 9 parts of 120 parts of Radix Et Rhizoma Rhei, 97 parts of Rhizoma Coptidis, 95 parts of Radix Notoginseng, 90 parts of the Radixs Angelicae Dahuricae, 55 parts of Sanguis Draxonis, 83 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 85 parts of Endoconcha Sepiaes, 28 parts in Radix Glycyrrhizae, 15 parts of Margaritas and Borneolum Syntheticums.
A kind of digestive tract ulcer, hemorrhage Chinese medicine composition for the treatment of, its raw material weight component is: 9 parts of 120 parts of Radix Et Rhizoma Rhei, 97 parts of Rhizoma Coptidis, 95 parts of Radix Notoginseng, 90 parts of the Radixs Angelicae Dahuricae, 55 parts of Sanguis Draxonis, 83 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 85 parts of Endoconcha Sepiaes, 28 parts in Radix Glycyrrhizae, 15 parts of Margaritas and Borneolum Syntheticums.
A kind of preparation method for the treatment of digestive tract ulcer, hemorrhage Chinese medicine composition comprises the following steps:
The first step, 120 parts of Radix Et Rhizoma Rhei, 97 parts of Rhizoma Coptidis, 95 parts of Radix Notoginseng, 90 parts of the Radixs Angelicae Dahuricae and Radix Glycyrrhizae are ground into 20 order coarse powder for 28 parts, add 70% ethanol of 4 times of amounts of above-mentioned five kinds of medicine gross weights, be heated to 81 ℃ of backflow secondaries, each 3 hours, pour out decoction liquor, repeat above decoction process again, pour out decoction liquor, merge decoction liquor twice, filter, it is standby that recovery ethanol is made clear paste
Second step, with adding the water of 8 times of amounts of medicine weight behind 20 whitish eye of the medicinal residues in the first step and 83 parts and the coarse powder mix homogeneously, be heated to 99 ℃ and decoct twice, each 1 hour, merge decoction liquor twice, filter with 200 order stainless steel meshs, mix, be condensed into relative density in 68 ℃ and be determined as 1.37 thick paste at 60 ℃ with the clear paste that the first step is made, be dried to dried cream in 74 ℃, pulverized 80 eye mesh screens, it is standby to make medicated powder
The 3rd step was ground into fine powder for 85 parts with 15 parts of Margaritas, Endoconcha Sepiae, and the fineness of Margarita, Endoconcha Sepiae is 300 orders, and is standby,
The 4th step; 55 parts of Sanguis Draxonis are ground into 100 order fine powders separately,, add 95% ethanol that accounts for mixed powder weight 10% and mix with the second step gained medicated powder, the 3rd step gained medicated powder mix homogeneously; make soft material; in granulator, granulate, in hothouse,, cross 20 mesh sieves with 75 ℃ temperature drying 1.5 hours with 20 eye mesh screens; add 9 parts of 60 purpose Borneolum Syntheticums again; mix homogeneously is filled to capsule, promptly.
Embodiment 7
A kind of digestive tract ulcer, hemorrhage Chinese medicine composition for the treatment of, its raw material weight component comprises: 6 parts of 95 parts of Radix Et Rhizoma Rhei, 80 parts of Rhizoma Coptidis, 85 parts of Radix Notoginseng, 70 parts of the Radixs Angelicae Dahuricae, 50 parts of Sanguis Draxonis, 75 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 80 parts of Endoconcha Sepiaes, 24 parts in Radix Glycyrrhizae, 11 parts of Margaritas and Borneolum Syntheticums.
A kind of digestive tract ulcer, hemorrhage Chinese medicine composition for the treatment of, its raw material weight component is: 6 parts of 95 parts of Radix Et Rhizoma Rhei, 80 parts of Rhizoma Coptidis, 85 parts of Radix Notoginseng, 70 parts of the Radixs Angelicae Dahuricae, 50 parts of Sanguis Draxonis, 75 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 80 parts of Endoconcha Sepiaes, 24 parts in Radix Glycyrrhizae, 11 parts of Margaritas and Borneolum Syntheticums.
A kind of preparation method for the treatment of digestive tract ulcer, hemorrhage Chinese medicine composition comprises the following steps:
The first step, 95 parts of Radix Et Rhizoma Rhei, 80 parts of Rhizoma Coptidis, 85 parts of Radix Notoginseng, 70 parts of the Radixs Angelicae Dahuricae and Radix Glycyrrhizae are ground into 20 order coarse powder for 24 parts, add 67% ethanol of 6 times of amounts of above-mentioned five kinds of medicine gross weights, be heated to 88 ℃ of backflow secondaries, each 3 hours, pour out decoction liquor, repeat above decoction process again, pour out decoction liquor, merge decoction liquor twice, filter, it is standby that recovery ethanol is made clear paste
Second step, with adding the water of 10 times of amounts of medicine weight behind 20 whitish eye of the medicinal residues in the first step and 75 parts and the coarse powder mix homogeneously, be heated to 96 ℃ and decoct twice, each 2 hours, merge decoction liquor twice, filter with 200 order stainless steel meshs, mix, be condensed into relative density in 79 ℃ and be determined as 1.38 thick paste at 60 ℃ with the clear paste that the first step is made, be dried to dried cream in 72 ℃, pulverized 80 eye mesh screens, it is standby to make medicated powder
The 3rd step was ground into fine powder for 80 parts with 11 parts of Margaritas, Endoconcha Sepiae, and the fineness of Margarita, Endoconcha Sepiae is 300 orders, and is standby,
The 4th step; 50 parts of Sanguis Draxonis are ground into 60 order fine powders separately,, add 86% ethanol that accounts for mixed powder weight 22% and mix with the second step gained medicated powder, the 3rd step gained medicated powder mix homogeneously; make soft material; in granulator, granulate, in hothouse,, cross 20 mesh sieves with 78 ℃ temperature drying 1.5 hours with 20 eye mesh screens; add 6 parts of 60 purpose Borneolum Syntheticums again; mix homogeneously is filled to capsule, promptly.
Embodiment 8
A kind of digestive tract ulcer, hemorrhage Chinese medicine composition for the treatment of, its raw material weight component comprises: 5 parts of 88 parts of Radix Et Rhizoma Rhei, 70 parts of Rhizoma Coptidis, 80 parts of Radix Notoginseng, 55 parts of the Radixs Angelicae Dahuricae, 53 parts of Sanguis Draxonis, 68 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 70 parts of Endoconcha Sepiaes, 16 parts in Radix Glycyrrhizae, 6 parts of Margaritas and Borneolum Syntheticums.
A kind of digestive tract ulcer, hemorrhage Chinese medicine composition for the treatment of, its raw material weight component is: 5 parts of 88 parts of Radix Et Rhizoma Rhei, 70 parts of Rhizoma Coptidis, 80 parts of Radix Notoginseng, 55 parts of the Radixs Angelicae Dahuricae, 53 parts of Sanguis Draxonis, 68 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 70 parts of Endoconcha Sepiaes, 16 parts in Radix Glycyrrhizae, 6 parts of Margaritas and Borneolum Syntheticums.
A kind of preparation method for the treatment of digestive tract ulcer, hemorrhage Chinese medicine composition comprises the following steps:
The first step, 88 parts of Radix Et Rhizoma Rhei, 70 parts of Rhizoma Coptidis, 80 parts of Radix Notoginseng, 55 parts of the Radixs Angelicae Dahuricae and Radix Glycyrrhizae are ground into 20 order coarse powder for 16 parts, add 85% ethanol of 5 times of amounts of above-mentioned five kinds of medicine gross weights, be heated to 83 ℃ of backflow secondaries, each 1 hour, pour out decoction liquor, repeat above decoction process again, pour out decoction liquor, merge decoction liquor twice, filter, it is standby that recovery ethanol is made clear paste
Second step, with adding the water of 12 times of amounts of medicine weight behind 20 whitish eye of the medicinal residues in the first step and 68 parts and the coarse powder mix homogeneously, be heated to 95 ℃ and decoct twice, each 1.5 hours, merge decoction liquor twice, filter with 200 order stainless steel meshs, mix, be condensed into relative density in 63 ℃ and be determined as 1.35 thick paste at 60 ℃ with the clear paste that the first step is made, be dried to dried cream in 74 ℃, pulverized 80 eye mesh screens, it is standby to make medicated powder
The 3rd step was ground into fine powder for 70 parts with 6 parts of Margaritas, Endoconcha Sepiae, and the fineness of Margarita, Endoconcha Sepiae is 300 orders, and is standby,
The 4th step; 53 parts of Sanguis Draxonis are ground into 100 order fine powders separately,, add 78% ethanol that accounts for mixed powder weight 18% and mix with the second step gained medicated powder, the 3rd step gained medicated powder mix homogeneously; make soft material; in granulator, granulate, in hothouse,, cross 20 mesh sieves with 80 ℃ temperature drying 1 hour with 20 eye mesh screens; add 5 parts of 60 purpose Borneolum Syntheticums again; mix homogeneously is filled to capsule, promptly.
Embodiment 9
A kind of digestive tract ulcer, hemorrhage Chinese medicine composition for the treatment of, its raw material weight component comprises: 7 parts of 100 parts of Radix Et Rhizoma Rhei, 85 parts of Rhizoma Coptidis, 80 parts of Radix Notoginseng, 75 parts of the Radixs Angelicae Dahuricae, 46 parts of Sanguis Draxonis, 75 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 80 parts of Endoconcha Sepiaes, 23 parts in Radix Glycyrrhizae, 10 parts of Margaritas and Borneolum Syntheticums.
A kind of digestive tract ulcer, hemorrhage Chinese medicine composition for the treatment of, its raw material weight component is: 7 parts of 100 parts of Radix Et Rhizoma Rhei, 85 parts of Rhizoma Coptidis, 80 parts of Radix Notoginseng, 75 parts of the Radixs Angelicae Dahuricae, 46 parts of Sanguis Draxonis, 75 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 80 parts of Endoconcha Sepiaes, 23 parts in Radix Glycyrrhizae, 10 parts of Margaritas and Borneolum Syntheticums.
A kind of preparation method for the treatment of digestive tract ulcer, hemorrhage Chinese medicine composition comprises the following steps:
The first step, 100 parts of Radix Et Rhizoma Rhei, 85 parts of Rhizoma Coptidis, 80 parts of Radix Notoginseng, 75 parts of the Radixs Angelicae Dahuricae and Radix Glycyrrhizae are ground into 20 order coarse powder for 23 parts, add 66% ethanol of 4 times of amounts of above-mentioned five kinds of medicine gross weights, be heated to 82 ℃ of backflow secondaries, each 2 hours, pour out decoction liquor, repeat above decoction process again, pour out decoction liquor, merge decoction liquor twice, filter, it is standby that recovery ethanol is made clear paste
Second step, with adding the water of 9 times of amounts of medicine weight behind 20 whitish eye of the medicinal residues in the first step and 75 parts and the coarse powder mix homogeneously, be heated to 99 ℃ and decoct twice, each 1.5 hours, merge decoction liquor twice, filter with 200 order stainless steel meshs, mix, be condensed into relative density in 62 ℃ and be determined as 1.36 thick paste at 60 ℃ with the clear paste that the first step is made, be dried to dried cream in 80 ℃, pulverized 80 eye mesh screens, it is standby to make medicated powder
The 3rd step was ground into fine powder for 80 parts with 10 parts of Margaritas, Endoconcha Sepiae, and the fineness of Margarita, Endoconcha Sepiae is 300 orders, and is standby,
The 4th step; 46 parts of Sanguis Draxonis are ground into 80 order fine powders separately,, add 80% ethanol that accounts for mixed powder weight 14% and mix with the second step gained medicated powder, the 3rd step gained medicated powder mix homogeneously; make soft material; in granulator, granulate, in hothouse,, cross 20 mesh sieves with 68 ℃ temperature drying 2 hours with 20 eye mesh screens; add 7 parts of 60 purpose Borneolum Syntheticums again; mix homogeneously is filled to capsule, promptly.
Embodiment 10
A kind of digestive tract ulcer, hemorrhage Chinese medicine composition for the treatment of, its raw material weight component comprises: 10 parts of 115 parts of Radix Et Rhizoma Rhei, 90 parts of Rhizoma Coptidis, 90 parts of Radix Notoginseng, 85 parts of the Radixs Angelicae Dahuricae, 60 parts of Sanguis Draxonis, 90 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 85 parts of Endoconcha Sepiaes, 26 parts in Radix Glycyrrhizae, 13 parts of Margaritas and Borneolum Syntheticums.
A kind of digestive tract ulcer, hemorrhage Chinese medicine composition for the treatment of, its raw material weight component is: 10 parts of 115 parts of Radix Et Rhizoma Rhei, 90 parts of Rhizoma Coptidis, 90 parts of Radix Notoginseng, 85 parts of the Radixs Angelicae Dahuricae, 60 parts of Sanguis Draxonis, 90 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 85 parts of Endoconcha Sepiaes, 26 parts in Radix Glycyrrhizae, 13 parts of Margaritas and Borneolum Syntheticums.
A kind of preparation method for the treatment of digestive tract ulcer, hemorrhage Chinese medicine composition comprises the following steps:
The first step, 115 parts of Radix Et Rhizoma Rhei, 90 parts of Rhizoma Coptidis, 90 parts of Radix Notoginseng, 85 parts of the Radixs Angelicae Dahuricae and Radix Glycyrrhizae are ground into 20 order coarse powder for 26 parts, add 78% ethanol of 5 times of amounts of above-mentioned five kinds of medicine gross weights, be heated to 86 ℃ of backflow secondaries, each 2 hours, pour out decoction liquor, repeat above decoction process again, pour out decoction liquor, merge decoction liquor twice, filter, it is standby that recovery ethanol is made clear paste
Second step, with adding the water of 11 times of amounts of medicine weight behind 20 whitish eye of the medicinal residues in the first step and 90 parts and the coarse powder mix homogeneously, be heated to 93 ℃ and decoct twice, each 2 hours, merge decoction liquor twice, filter with 200 order stainless steel meshs, mix, be condensed into relative density in 68 ℃ and be determined as 1.37 thick paste at 60 ℃ with the clear paste that the first step is made, be dried to dried cream in 73 ℃, pulverized 80 eye mesh screens, it is standby to make medicated powder
The 3rd step was ground into fine powder for 85 parts with 13 parts of Margaritas, Endoconcha Sepiae, and the fineness of Margarita, Endoconcha Sepiae is 300 orders, and is standby,
The 4th step; 60 parts of Sanguis Draxonis are ground into 100 order fine powders separately,, add 86% ethanol that accounts for mixed powder weight 24% and mix with the second step gained medicated powder, the 3rd step gained medicated powder mix homogeneously; make soft material; in granulator, granulate, in hothouse,, cross 20 mesh sieves with 75 ℃ temperature drying 1.5 hours with 20 eye mesh screens; add 10 parts of 60 purpose Borneolum Syntheticums again; mix homogeneously is filled to capsule, promptly.
Animal acute toxicity and clinical observation
One, animal acute toxicity test
1 test objective: observe the reaction of the embodiment of the invention 3 capsule animal acute toxicities, measure animal median lethal dose(LD 50) or maximum tolerated dose.
2 animals: ICR strain mice, male and female dual-purpose, body weight 20 ± 2g, the quality certification number: the moving card of Shan doctor word 08-004.
3 route of administration: gastric infusion.
4 test ambient temperature, humidity: 20～22 ℃ of room temperatures, relative humidity 62～65%.
5 methods
5.1 trial test: the grouping geometric ratio series dosage embodiment of the invention 3 capsule medicated powder gastric infusions were observed 7 days, can't find minimum complete dead amount.So formal test changes the survey maximum tolerated dose.
5.2 formal experiment: get 20 of ICR strain mices, male and female half and half are weighed and are numbered labelling.Pour out the embodiment of the invention 3 capsule medicated powder, being made into maximum concentration (not stopping up the mouse stomach syringe needle) with distilled water is 24.6% suspension, and mice state on an empty stomach press the 0.4mL/10g body weight down and irritates stomach, irritates stomach the same day altogether 3 times (interval 4h).After the administration, mice is put into animal feeding room, and conventional feed is freely drunk water, and observes continuously 15.
5 results: test mice does not have death, does not observe other physiology and dystropy yet.The animal dislocation is put to death the back and is dissected, and it is unusual that naked eyes are not observed internal organs such as gastrointestinal tract, the heart, liver, kidney.The prompting mice can tolerate the embodiment of the invention 3 capsule medicated powder gastric infusions of maximum concentration, heap(ed) capacity.
6 brief summaries: the embodiment of the invention 3 capsule mice maximum tolerated doses are the 29.52g/kg body weight, are equivalent to clinical people and intend 369 times (body weight for humans is by 60kg) with dosage (4.8g/d).
Two, the embodiment of the invention 9 capsule clinical observation on the therapeutic effect
1 is subjected to the reagent thing: the embodiment of the invention 9 capsules, 400mg/ grain.
2 test objectives: observe the curative effect and the dosage (4/time of client's recommended doses, 3 times/day) thereof of anti-alimentary tract ulcer (comprising its hemorrhage complication), observing it simultaneously may untoward reaction.
3 are tried case selection principle: gastroscopy is diagnosed as stomach or duodenal ulcer patients, gastric ulcer diameter 〉=0.5cm, duodenal ulcer diameter≤0.3cm, all get rid of pyloric obstruction, gastric perforation etc. and issue licence, gastric ulcer is got rid of canceration, sex, age are not limit, I freely accept the embodiment of the invention 9 capsule for treating voluntarily, duration of test other anti-peptic ulcer drugs of stopping using, patient's can be in hospital and also can not be in hospital (be in hospital and various first visit inspection fees are taken care of oneself, bear by test unit by the inspection fee that the doctor arranges) based on therapeutic evaluation.Because of withdrawing from the experimenter, do not add up a variety of causes.
4 case data: all cases are the outpatient.Patient takes into account factor equilibriums such as age, sex, is divided into 2 groups at random according to the state of an illness, the course of disease.Test group case 68 examples, wherein male 46 examples, women 22 examples, 20～64 years old age, the course of disease 20 days～8 years, 33 examples (accounting for 48.5%) more than 2 years wherein, gastric ulcer 19 examples, duodenal ulcer 39 examples, compound ulcer 10 examples, pylori detects positive 47 examples, companion's digestive tract hemorrhage 11 examples; Matched group case 60 examples, wherein male 50 examples, women 10 examples, 21～67 years old age, the course of disease 16 days～12 years, 28 examples (accounting for 46.7%) more than 2 years wherein, gastric ulcer 16 examples, duodenal ulcer 38 examples, compound ulcer 6 examples, pylori detects positive 46 examples, companion's digestive tract hemorrhage 9 examples.
5 Therapeutic Method: 3 of the oral embodiment of the invention 9 capsules of test group, 4 times/day, take 4 weeks of continuous use respectively at 0.5h before sleeping in 1h and evening after meal.The patient serve on 1 all conscious nonresponders can withdraw from test voluntarily, serve on 2 all nonresponder doctors and advises termination test and use the treatment of control group method instead, and eliminate out test.The oral ranitidine sheet of matched group (150mg/ time, 2 times/day, on an empty stomach), Amoxicillin Capsules (500mg/ time, 3 times/day, after meal), the bismuth pectin capsule (100mg/ time, 3 times/day, ante cibum), treated for 4 weeks.
6 clinical indexes: stomachache remission time, hematemesis, the equal extinction time of melena (concurrent bleeder is arranged), fecal occult blood testing (concurrent bleeder being arranged), gastroscopy, helicobacter pylori test (urease methods), the untoward reaction of medication process through treatment hematemesis, the melena person of stopping.
7 therapeutic evaluation standards: cure: main symptom with and issue licence and all disappear (comprising that concurrent bleeder hematemesis in 1 week, melena stop continuous 3 days feminine genders of fecal occult blood testing), the gastroscopy ulcer surface all disappears, and slight hyperemia is arranged, no edema is followed up a case by regular visits to not have in 1 year and is recurred.Produce effects: main symptom with and issue licence and all have clear improvement, or indivedual main symptom slightly improves, other symptoms all disappear, the gastroscopy ulcer surface heals substantially, still has Mild edema, follows up a case by regular visits to and does not have recurrence in half a year.Effectively: main symptom with and issue licence improvement all arranged, or main symptom improves stage arranged, but and issue licence and all disappear, the gastroscopy ulcer surface obviously dwindles more than 50%.Invalid: main symptom with and issue licence and all do not have improvement, the gastroscopy ulcer surface dwindles and is less than 50%.
8 result of the tests
8.1 general curative effect: equal failed call withdraws from test in the voluntary case therapeutic process that participates in testing, and all subjectivity thinks that symptom has improvement in various degree.Test group patient is not reflected obvious adverse reaction, but the most patients' reflections of matched group have abdominal distention, bitter taste, xerostomia and dizziness, headache, uncomfortable sensation such as tired, also there are 8 patient's reflections that insomnia is arranged, wherein 1 old man has a sleepless night seriously, be to add diazepam evening, have 4 middle aged patients to reflect that the period in a medicine sexual function obviously descends.Illustrate that the embodiment of the invention 9 capsules compared to the Western medicine Comprehensive Treatment, have no adverse reaction.As shown in table 1,2 groups of comprehensive therapeutic effect evaluations show that test group total effective rate and matched group are near (94.1%vs 95.0%), and cure rate is also near (41.2%vs 43.3%).Inventive embodiments 9 capsule determined curative effects are described, are not less than the Western medicine Comprehensive Treatment.
Table 1 embodiment of the invention 9 capsule for treating digestive tract general curative effects
Compare * P＞0.05 with matched group
8.2 stomachache remission time: as shown in table 2, all patients' alleviation of suffering from abdominal pain in the test group medication 4 days, wherein 23.5% patient on the 1st alleviations of suffering from abdominal pain, whole patients just alleviation of suffering from abdominal pain in 2 weeks of matched group medication.The prompting embodiment of the invention 9 capsules are alleviated digestive tract ulcer stomachache and are issued licence with the obvious advantage.
Table 2 stomachache is alleviated case (%) and treatment time relation
8.3 anastalsis: test group medication patient's hematemesis, melena on the 2nd～5 all disappear, matched group medication the 4th day～2 all hematemesis, melena just disappear (table 3).Illustrate that inventive embodiments 9 capsules control digestive tract ulcer is hemorrhage and the effect of issuing licence is obvious, have direct anastalsis.Fecal occult blood testing result (table 4) also supports its anastalsis.
Table 3 hematemesis, melena disappearance case (%) and treatment time relation
Table 4 fecal occult blood turn out cloudy case (%) with treatment time relation
8.4 anti-helicobacter pylori effect: as shown in table 5, the forward and backward helicobacter pylori positive rate of test group patient treatment is compared with matched group does not respectively all have remarkable statistical significance (P＞0.05).Illustrate that inventive embodiments 9 capsules also have anti-helicobacter pylori effect, promptly have the meaning of etiological treatment to digestive tract ulcer.
Table 5 helicobacter pylori positive case (%)
Compare * P＞0.05 with matched group
9 conclusion (of pressure testing)s: the embodiment of the invention 9 capsule for treating digestive tract ulcer (comprise that it is hemorrhage and issue licence) curative effect is clear and definite, its main characteristic is to alleviate stomachache and direct anastalsis fast, simultaneously anti-helicobacter pylori effect may be arranged also, promptly peptic ulcer be had the meaning of etiological treatment; Oral 3/time, 4 times/day medication is feasible, suggestion extend the period of treatment may curative effect can be better; Compare with Western medicine, the embodiment of the invention 9 capsules have no adverse reaction.
Claims (10)
1. treat digestive tract ulcer, hemorrhage Chinese medicine composition for one kind, it is characterized in that its raw material weight component comprises:
Radix Et Rhizoma Rhei 80-120 part, Rhizoma Coptidis 70-100 part, Radix Notoginseng 70-100 part, Radix Angelicae Dahuricae 50-90 part, Sanguis Draxonis 30-60 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 60-90 part, Endoconcha Sepiae 60-90 part, Radix Glycyrrhizae 15-30 part, Margarita 5-15 part and Borneolum Syntheticum 5-10 part.
2. a kind of digestive tract ulcer, hemorrhage Chinese medicine composition for the treatment of according to claim 1 is characterized in that its raw material weight component is:
Radix Et Rhizoma Rhei 80-120 part, Rhizoma Coptidis 70-100 part, Radix Notoginseng 70-100 part, Radix Angelicae Dahuricae 50-90 part, Sanguis Draxonis 30-60 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 60-90 part, Endoconcha Sepiae 60-90 part, Radix Glycyrrhizae 15-30 part, Margarita 5-15 part and Borneolum Syntheticum 5-10 part.
3. a kind of digestive tract ulcer, hemorrhage Chinese medicine composition for the treatment of of stating according to claim 2 is characterized in that its raw material weight component is:
Radix Et Rhizoma Rhei 90-110 part, Rhizoma Coptidis 80-90 part, Radix Notoginseng 80-90 part, Radix Angelicae Dahuricae 65-75 part, Sanguis Draxonis 40-50 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 70-80 part, Endoconcha Sepiae 70-80 part, Radix Glycyrrhizae 20-30 part, Margarita 10-15 part and Borneolum Syntheticum 5-10 part.
4. a kind of digestive tract ulcer, hemorrhage Chinese medicine composition for the treatment of of stating according to claim 2 is characterized in that its raw material weight component is:
6 parts of 85 parts of Radix Et Rhizoma Rhei, 80 parts of Rhizoma Coptidis, 75 parts of Radix Notoginseng, 60 parts of the Radixs Angelicae Dahuricae, 30 parts of Sanguis Draxonis, 70 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 60 parts of Endoconcha Sepiaes, 18 parts in Radix Glycyrrhizae, 8 parts of Margaritas and Borneolum Syntheticums.
5. a kind of digestive tract ulcer, hemorrhage Chinese medicine composition for the treatment of of stating according to claim 2 is characterized in that its raw material weight component is:
9 parts of 100 parts of Radix Et Rhizoma Rhei, 85 parts of Rhizoma Coptidis, 85 parts of Radix Notoginseng, 70 parts of the Radixs Angelicae Dahuricae, 45 parts of Sanguis Draxonis, 75 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 75 parts of Endoconcha Sepiaes, 25 parts in Radix Glycyrrhizae, 14 parts of Margaritas and Borneolum Syntheticums.
6. a kind of digestive tract ulcer, hemorrhage Chinese medicine composition for the treatment of of stating according to claim 2 is characterized in that its raw material weight component is:
7 parts of 105 parts of Radix Et Rhizoma Rhei, 85 parts of Rhizoma Coptidis, 85 parts of Radix Notoginseng, 75 parts of the Radixs Angelicae Dahuricae, 40 parts of Sanguis Draxonis, 70 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 70 parts of Endoconcha Sepiaes, 22 parts in Radix Glycyrrhizae, 12 parts of Margaritas and Borneolum Syntheticums.
7. a kind of digestive tract ulcer, hemorrhage Chinese medicine composition for the treatment of of stating according to claim 2 is characterized in that its raw material weight component is:
9 parts of 120 parts of Radix Et Rhizoma Rhei, 97 parts of Rhizoma Coptidis, 95 parts of Radix Notoginseng, 90 parts of the Radixs Angelicae Dahuricae, 55 parts of Sanguis Draxonis, 83 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 85 parts of Endoconcha Sepiaes, 28 parts in Radix Glycyrrhizae, 15 parts of Margaritas and Borneolum Syntheticums.
8. a kind of digestive tract ulcer, hemorrhage Chinese medicine composition for the treatment of of stating according to claim 2 is characterized in that its raw material weight component is:
5 parts of 88 parts of Radix Et Rhizoma Rhei, 70 parts of Rhizoma Coptidis, 80 parts of Radix Notoginseng, 55 parts of the Radixs Angelicae Dahuricae, 53 parts of Sanguis Draxonis, 68 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 70 parts of Endoconcha Sepiaes, 16 parts in Radix Glycyrrhizae, 6 parts of Margaritas and Borneolum Syntheticums.
9. a kind of digestive tract ulcer, hemorrhage Chinese medicine composition for the treatment of of stating according to claim 2 is characterized in that its raw material weight component is:
7 parts of 100 parts of Radix Et Rhizoma Rhei, 85 parts of Rhizoma Coptidis, 80 parts of Radix Notoginseng, 75 parts of the Radixs Angelicae Dahuricae, 46 parts of Sanguis Draxonis, 75 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 80 parts of Endoconcha Sepiaes, 23 parts in Radix Glycyrrhizae, 10 parts of Margaritas and Borneolum Syntheticums.
10. a preparation method for the treatment of digestive tract ulcer, hemorrhage Chinese medicine composition comprises the following steps:
The first step, 80～120 parts of Radix Et Rhizoma Rhei, 70～100 parts of Rhizoma Coptidis, 70～100 parts of Radix Notoginseng, 50～90 parts of the Radixs Angelicae Dahuricae and Radix Glycyrrhizae are ground into 18～30 order coarse powder for 15～30 parts, add 60～90% ethanol of 4～6 times of amounts of above-mentioned five kinds of medicine gross weights, be heated to 75～90 ℃ of backflow secondaries, each 1～3 hour, pour out decoction liquor, repeat above decoction process again, pour out decoction liquor, merge decoction liquor twice, filter, it is standby that recovery ethanol is made clear paste
Second step, to add the water of 8～12 times of amounts of medicine weight behind the medicinal residues in the first step and 60～90 part of 20 purpose Pseudobulbus Bletillae (Rhizoma Bletillae) coarse powder mix homogeneously, be heated to 90 ℃～100 ℃ and decoct twice, each 1～3 hour, merge decoction liquor twice, filter with 200 order stainless steel meshs, mix, be condensed into relative density in 60～80 ℃ and be determined as 1.35～1.38 thick paste at 60 ℃ with the clear paste that the first step is made, be dried to dried cream in 60 ℃～80 ℃, pulverized 80 eye mesh screens, it is standby to make medicated powder
The 3rd step was ground into fine powder for 60～90 parts with 5～15 parts of Margaritas, Endoconcha Sepiae, and the fineness of Margarita, Endoconcha Sepiae is 300 orders, and is standby,
The 4th step; 30～60 parts of Sanguis Draxonis are ground into 60-100 order fine powder separately,, add 75～95% ethanol that account for mixed powder weight 10～30% and mix with the second step gained medicated powder, the 3rd step gained medicated powder mix homogeneously; make soft material; in granulator, granulate, in hothouse,, cross 20 mesh sieves with 60～80 ℃ temperature drying 1～2 hour with 20 eye mesh screens; add 5～10 parts of 60 purpose Borneolum Syntheticums again; mix homogeneously is filled to capsule, promptly.
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| CN103463429A (en) * | 2012-06-06 | 2013-12-25 | 邵洪锦 | Enema retention traditional Chinese medicine prescription ulcer healing powder for treatment of ulcerative colitis |
| CN104352793A (en) * | 2014-11-21 | 2015-02-18 | 崔合芳 | Traditional Chinese medicine preparation for treating gastrointestinal bleeding and preparation method thereof |
| CN104740344A (en) * | 2015-03-12 | 2015-07-01 | 刘亮 | Chinese medicinal emulsion for treating peptic ulcer and preparation method |
| CN110787261A (en) * | 2019-12-13 | 2020-02-14 | 西安千禾药业股份有限公司 | Ointment for clearing heat, cooling blood, stopping bleeding, relieving swelling and promoting wound healing and preparation method thereof |
| CN115381899A (en) * | 2022-09-30 | 2022-11-25 | 江炽荣 | Preparation for treating visceral perforation hemorrhage and preparation method thereof |
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