CN104013806A - Traditional Chinese medicine composition for treating diabetes mellitus - Google Patents
Traditional Chinese medicine composition for treating diabetes mellitus Download PDFInfo
- Publication number
- CN104013806A CN104013806A CN201410287755.4A CN201410287755A CN104013806A CN 104013806 A CN104013806 A CN 104013806A CN 201410287755 A CN201410287755 A CN 201410287755A CN 104013806 A CN104013806 A CN 104013806A
- Authority
- CN
- China
- Prior art keywords
- weight portions
- parts
- diabetes mellitus
- radix
- chinese prescription
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 206010012601 diabetes mellitus Diseases 0.000 title claims abstract description 28
- 239000003814 drug Substances 0.000 title abstract description 12
- 239000000203 mixture Substances 0.000 title abstract description 12
- 241000180649 Panax notoginseng Species 0.000 claims abstract description 16
- 235000003143 Panax notoginseng Nutrition 0.000 claims abstract description 16
- 239000009636 Huang Qi Substances 0.000 claims description 16
- 241000208340 Araliaceae Species 0.000 claims description 15
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims description 15
- 235000003140 Panax quinquefolius Nutrition 0.000 claims description 15
- 235000008434 ginseng Nutrition 0.000 claims description 15
- 241001619461 Poria <basidiomycete fungus> Species 0.000 claims description 14
- 241000237903 Hirudo Species 0.000 claims description 11
- 241000522620 Scorpio Species 0.000 claims description 11
- 239000009490 scorpio Substances 0.000 claims description 11
- 239000008187 granular material Substances 0.000 claims description 10
- 239000002671 adjuvant Substances 0.000 claims description 5
- 239000002552 dosage form Substances 0.000 claims description 4
- 239000008280 blood Substances 0.000 abstract description 25
- 210000004369 blood Anatomy 0.000 abstract description 25
- 230000000694 effects Effects 0.000 abstract description 6
- 210000000952 spleen Anatomy 0.000 abstract description 5
- 238000000034 method Methods 0.000 abstract description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 3
- 230000001603 reducing effect Effects 0.000 abstract description 3
- 230000001502 supplementing effect Effects 0.000 abstract description 3
- 201000010099 disease Diseases 0.000 abstract description 2
- 230000008506 pathogenesis Effects 0.000 abstract description 2
- 241000045403 Astragalus propinquus Species 0.000 abstract 1
- 241000132012 Atractylodes Species 0.000 abstract 1
- 244000247747 Coptis groenlandica Species 0.000 abstract 1
- 235000002991 Coptis groenlandica Nutrition 0.000 abstract 1
- 244000301850 Cupressus sempervirens Species 0.000 abstract 1
- 244000241838 Lycium barbarum Species 0.000 abstract 1
- 235000015459 Lycium barbarum Nutrition 0.000 abstract 1
- 235000015468 Lycium chinense Nutrition 0.000 abstract 1
- 235000002789 Panax ginseng Nutrition 0.000 abstract 1
- 244000248825 Peltandra virginica Species 0.000 abstract 1
- 235000001188 Peltandra virginica Nutrition 0.000 abstract 1
- 235000008599 Poria cocos Nutrition 0.000 abstract 1
- 244000046146 Pueraria lobata Species 0.000 abstract 1
- 235000010575 Pueraria lobata Nutrition 0.000 abstract 1
- 244000299790 Rheum rhabarbarum Species 0.000 abstract 1
- 235000009411 Rheum rhabarbarum Nutrition 0.000 abstract 1
- 235000017276 Salvia Nutrition 0.000 abstract 1
- 240000007164 Salvia officinalis Species 0.000 abstract 1
- 240000006079 Schisandra chinensis Species 0.000 abstract 1
- 235000008422 Schisandra chinensis Nutrition 0.000 abstract 1
- 230000003213 activating effect Effects 0.000 abstract 1
- 230000006978 adaptation Effects 0.000 abstract 1
- 235000006533 astragalus Nutrition 0.000 abstract 1
- 238000001816 cooling Methods 0.000 abstract 1
- 230000004792 oxidative damage Effects 0.000 abstract 1
- 239000002994 raw material Substances 0.000 abstract 1
- 238000005728 strengthening Methods 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 12
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 6
- HIMXGTXNXJYFGB-UHFFFAOYSA-N alloxan Chemical compound O=C1NC(=O)C(=O)C(=O)N1 HIMXGTXNXJYFGB-UHFFFAOYSA-N 0.000 description 6
- 239000008103 glucose Substances 0.000 description 6
- 230000001737 promoting effect Effects 0.000 description 5
- 208000001072 type 2 diabetes mellitus Diseases 0.000 description 5
- 241000283973 Oryctolagus cuniculus Species 0.000 description 4
- 230000017531 blood circulation Effects 0.000 description 4
- 230000006837 decompression Effects 0.000 description 4
- 239000000706 filtrate Substances 0.000 description 4
- 239000012530 fluid Substances 0.000 description 4
- 210000003128 head Anatomy 0.000 description 4
- 239000007779 soft material Substances 0.000 description 4
- 230000000052 comparative effect Effects 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- 206010012735 Diarrhoea Diseases 0.000 description 2
- 208000031226 Hyperlipidaemia Diseases 0.000 description 2
- 206010062717 Increased upper airway secretion Diseases 0.000 description 2
- 230000002159 abnormal effect Effects 0.000 description 2
- 230000003078 antioxidant effect Effects 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 230000002641 glycemic effect Effects 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 230000001575 pathological effect Effects 0.000 description 2
- 208000026435 phlegm Diseases 0.000 description 2
- 231100000614 poison Toxicity 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 238000004064 recycling Methods 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 230000035900 sweating Effects 0.000 description 2
- 239000003440 toxic substance Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 206010010774 Constipation Diseases 0.000 description 1
- 206010016807 Fluid retention Diseases 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 206010022489 Insulin Resistance Diseases 0.000 description 1
- 108010028554 LDL Cholesterol Proteins 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 206010043949 Tongue discolouration Diseases 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000000812 cholinergic antagonist Substances 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 238000003748 differential diagnosis Methods 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 206010016256 fatigue Diseases 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 239000004518 granules dosage form Substances 0.000 description 1
- 230000002607 hemopoietic effect Effects 0.000 description 1
- 230000003345 hyperglycaemic effect Effects 0.000 description 1
- 201000001421 hyperglycemia Diseases 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000007373 indentation Methods 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- HHMSPIAOYISBOU-IYQBICMXSA-N insulin rabbit Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 HHMSPIAOYISBOU-IYQBICMXSA-N 0.000 description 1
- 230000003914 insulin secretion Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 208000007106 menorrhagia Diseases 0.000 description 1
- 230000002175 menstrual effect Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 206010062198 microangiopathy Diseases 0.000 description 1
- 210000003928 nasal cavity Anatomy 0.000 description 1
- 210000001331 nose Anatomy 0.000 description 1
- 210000004923 pancreatic tissue Anatomy 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 210000000578 peripheral nerve Anatomy 0.000 description 1
- 206010036067 polydipsia Diseases 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 208000037920 primary disease Diseases 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 230000002048 spasmolytic effect Effects 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000035922 thirst Effects 0.000 description 1
- 230000000451 tissue damage Effects 0.000 description 1
- 231100000827 tissue damage Toxicity 0.000 description 1
- 210000002105 tongue Anatomy 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a traditional Chinese medicine composition for treating diabetes mellitus. The traditional Chinese medicine composition for treating diabetes mellitus comprises the following raw materials in parts by weight: 25-35 parts of astragalus membranaceus, 10-20 parts of red ginseng, 30-40 parts of rhizoma polygonati, 10-20 parts of golden cypress, 10-20 parts of goldthread, 15-25 parts of root of red-rooted salvia, 10-20 parts of wolfberry, 15-25 parts of root of kudzu vine, 5-10 parts of panax notoginseng, 2-8 parts of torrefied rhubarb, 5-15 parts of schisandra chinensis, 15-25 parts of tuckahoe and 10-20 parts of white atractylodes rhizome. By adopting the traditional Chinese medicine composition, a method for cooling blood and activating blood is drawn up to treat diabetes mellitus on the basis of the method of tonifying the spleen and strengthening the middle warmer and supplementing qi and nourishing yin to treat diabetes mellitus for predecessors according to the ubiquitous blood stasis pathogenesis characteristic of the patient with the diabetes mellitus at present, the range of the adaptation disease of the theory studied by the predecessors is further expanded, and the traditional Chinese medicine composition has a good effect of reducing blood fat, can effectively resist oxidative damage, reduces IR, and simultaneously solves the problem of blood stasis of the patient with the diabetes mellitus effectively.
Description
Technical field
The present invention relates to tcm field, a kind of Chinese prescription that is used for the treatment of diabetes is provided especially.
Background technology
Treat for the differential diagnosis in tcm for the treatment of diabetes the Chinese patent medicine category that scheme is drafted based on the modern times, wherein mainly with spleen invigorating invigorating middle warmer, supplementing QI and nourishing YIN legislation, such Chinese patent medicine of clinical research confirmation can improve the thirsty polydipsia of diabetics, the symptoms such as fatigue and lack of strength, have good preventive and therapeutic effect to diabetes complicated microangiopathy and hyperlipidemia.
But along with the differentiation of modern genius morbi, in clinical practice, we find, blood stasis runs through in the whole course of disease in the pathogenic process of diabetes, has a strong impact on treatment and the rehabilitation of diabetics.
Therefore, research and development one can effectively solve blood stasis problem, is used for the treatment of the Chinese prescription of diabetes, becomes people's problem demanding prompt solution.
summary of the invention
Given this, the object of the present invention is to provide a kind of Chinese prescription that is used for the treatment of diabetes, cannot effectively solve with what at least solve that Chinese prescription in the past exists the blood stasis problem that diabetics exists, can also effectively reduce the hyperlipidemia of diabetics simultaneously, diabetics is had to anti oxidative damage, and minimizing insulin resistant (Insulin Resistance, IR).
The Chinese prescription that is used for the treatment of diabetes provided by the invention, it is characterized in that, described Chinese prescription comprises: the Radix Astragali 25 ~ 35 weight portions, Radix Ginseng Rubra 10 ~ 20 weight portions, Rhizoma Polygonati 30 ~ 40 weight portions, Cortex Phellodendri 10 ~ 20 weight portions, Rhizoma Coptidis 10 ~ 20 weight portions, Radix Salviae Miltiorrhizae 15 ~ 25 weight portions, Fructus Lycii 10 ~ 20 weight portions, Radix Puerariae 15 ~ 25 weight portions, Radix Notoginseng 5 ~ 10 weight portions, wine army 2 ~ 8 weight portions, Fructus Schisandrae Chinensis 5 ~ 15 weight portions, Poria 15 ~ 25 weight portions, the Rhizoma Atractylodis Macrocephalae 10 ~ 20 weight portions.
Preferably, described Chinese prescription comprises: the Radix Astragali 30 weight portions, Radix Ginseng Rubra 15 weight portions, Rhizoma Polygonati 35 weight portions, Cortex Phellodendri 15 weight portions, Rhizoma Coptidis 15 weight portions, Radix Salviae Miltiorrhizae 20 weight portions, Fructus Lycii 15 weight portions, Radix Puerariae 20 weight portions, Radix Notoginseng 7.5 weight portions, wine army 5 weight portions, Fructus Schisandrae Chinensis 10 weight portions, Poria 20 weight portions, the Rhizoma Atractylodis Macrocephalae 15 weight portions.
Further preferably, described Chinese prescription also comprises: Hirudo 2 ~ 5 weight portions, Scorpio 2 ~ 5 weight portions.
Further preferably, in described Chinese prescription, Hirudo is that 3.5 weight portions, Scorpio are 3.5 weight portions.
Further preferably, also comprise requirement adjuvant, the dosage form of described Chinese prescription is granule.
The Chinese prescription for the treatment of diabetes provided by the invention, it is the spleen invigorating invigorating middle warmer forefathers, supplementing QI and nourishing YIN ruling by law is treated on the basis of diabetes, according to the ubiquitous blood-stasis feature of modern diabetics, draft the ruling by law of removing heat from blood and promoting blood circulation and treat diabetes, further expand the indication scope of forefathers' research theory, there is the blood fat of reduction effective, effectively anti-oxidative damage, reduces IR, has the beneficial effect such as blood stasis problem of effective solution diabetics simultaneously.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is described in detail, but the multitude of different ways that the present invention can be defined by the claims and cover is implemented.
The basic pathogenesis of diabetes is that the deficiency of YIN is scorching.When Chinese traditional treatment primary disease, be main rule mainly with boosting qi and nourishing yin.And " based on heat-clearing and toxic substances removing, removing heat from blood and promoting blood circulation " thinking of the invention treatment diabetes.
Chinese prescription provided by the invention comprises: the Radix Astragali 25 ~ 35 weight portions, Radix Ginseng Rubra 10 ~ 20 weight portions, Rhizoma Polygonati 30 ~ 40 weight portions, Cortex Phellodendri 10 ~ 20 weight portions, Rhizoma Coptidis 10 ~ 20 weight portions, Radix Salviae Miltiorrhizae 15 ~ 25 weight portions, Fructus Lycii 10 ~ 20 weight portions, Radix Puerariae 15 ~ 25 weight portions, Radix Notoginseng 5 ~ 10 weight portions, wine army 2 ~ 8 weight portions, Fructus Schisandrae Chinensis 5 ~ 15 weight portions, Poria 15 ~ 25 weight portions, the Rhizoma Atractylodis Macrocephalae 10 ~ 20 weight portions.
Wherein, the Radix Astragali, Radix Ginseng Rubra, Rhizoma Polygonati: QI invigorating is held concurrently with yin nourishing; Poria, the Rhizoma Atractylodis Macrocephalae: spleen invigorating invigorating middle warmer; Fructus Lycii, Fructus Schisandrae Chinensis: kidney tonifying YIN nourishing; Cortex Phellodendri, Rhizoma Coptidis, wine army: heat-clearing and toxic substances removing; Radix Salviae Miltiorrhizae, Radix Notoginseng: removing heat from blood and promoting blood circulation and non-blood trouble; Radix Puerariae: promoting the production of body fluid to quench thirst; And Poria, the Rhizoma Atractylodis Macrocephalae and the Radix Astragali in this Chinese prescription, Radix Ginseng Rubra are compatible, get adopted Radix Astragali decoction of four noble drugs, and function is built Central Region in large scale, and eliminating dampness by diuresis is eliminated the phlegm.Taking type 2 diabetes mellitus from spleen, opinion is controlled as guiding theory, and can remove the pathological products such as phlegm retention water that with the passing of time type 2 diabetes mellitus given birth to is wet.
This Chinese prescription is according to following weight proportion, effect is better, is specially: the Radix Astragali 30 weight portions, Radix Ginseng Rubra 15 weight portions, Rhizoma Polygonati 35 weight portions, Cortex Phellodendri 15 weight portions, Rhizoma Coptidis 15 weight portions, Radix Salviae Miltiorrhizae 20 weight portions, Fructus Lycii 15 weight portions, Radix Puerariae 20 weight portions, Radix Notoginseng 7.5 weight portions, wine army 5 weight portions, Fructus Schisandrae Chinensis 10 weight portions, Poria 20 weight portions, the Rhizoma Atractylodis Macrocephalae 15 weight portions.
Part by weight between the each component embodying by above-mentioned weight portion mixes the prescription good effect making.Concrete composition may further include: Hirudo 2 ~ 5 weight portions, Scorpio 2 ~ 5 weight portions, preferably, Hirudo is that 3.5 weight portions, Scorpio are 3.5 weight portions.
Wherein, Hirudo: removing blood stasis stimulates the menstrual flow, Zhu Yu Xiao Disorder; Scorpio: removing obstruction in the collateral to relieve pain (mainly), endogenous wind stopping spasmolytic.Hirudo, Scorpio and Radix Notoginseng, wine army compatibility in Chinese prescription, strengthen former side's blood circulation promoting and blood stasis dispelling strength, pathological metabolism process that with the passing of time must the hemopoietic stasis of blood for type 2 diabetes mellitus, and have the function of the meridian dredging, can well improve type 2 diabetes mellitus peripheral nerve complication.
Chinese prescription provided by the invention preferably also comprises requirement adjuvant, and dosage form is granule.
The Chinese prescription its preparation method mixing is according to the above ratio: take each Chinese medicine ingredients according to aforementioned proportion and carry out decocting in water, filter to get filtrate, filtrate decompression is concentrated to obtain to thick paste I, by thick paste I precipitate with ethanol, leave standstill to obtain alcohol deposit fluid, by alcohol deposit fluid decompression recycling ethanol, obtain thick paste II, add adjuvant to make soft material, soft material carries out pelletize the most at last, makes granule.
Embodiment
In Chinese prescription provided by the invention, each Chinese medicine ingredients is commercially available.
The concrete preparation process of this Chinese prescription is as follows: proportionally take each Chinese medicine ingredients and carry out decocting in water, after boiling, after filtration, medicinal residues are given up, obtained filtrate, filtrate decompression is concentrated to obtain to thick paste I, by thick paste I precipitate with ethanol, leave standstill to obtain alcohol deposit fluid, by alcohol deposit fluid decompression recycling ethanol, obtain thick paste II, add adjuvant calcium carbonate to make soft material, soft material carries out pelletize the most at last, makes granule.Each embodiment is all prepared according to the method below.
Embodiment 1
A kind of Chinese prescription consists of the following composition, the Radix Astragali 25 weight portions, Radix Ginseng Rubra 20 weight portions, Rhizoma Polygonati 30 weight portions, Cortex Phellodendri 10 weight portions, Rhizoma Coptidis 20 weight portions, Radix Salviae Miltiorrhizae 25 weight portions, Fructus Lycii 20 weight portions, Radix Puerariae 15 weight portions, Radix Notoginseng 5 weight portions, wine army 8 weight portions, Fructus Schisandrae Chinensis 5 weight portions, Poria 25 weight portions, the Rhizoma Atractylodis Macrocephalae 10 weight portions.
Embodiment 2
A kind of Chinese prescription consists of the following composition, the Radix Astragali 35 weight portions, Radix Ginseng Rubra 10 weight portions, Rhizoma Polygonati 40 weight portions, Cortex Phellodendri 20 weight portions, Rhizoma Coptidis 10 weight portions, Radix Salviae Miltiorrhizae 15 weight portions, Fructus Lycii 10 weight portions, Radix Puerariae 25 weight portions, Radix Notoginseng 10 weight portions, wine army 2 weight portions, Fructus Schisandrae Chinensis 15 weight portions, Poria 15 weight portions, the Rhizoma Atractylodis Macrocephalae 20 weight portions.
Embodiment 3
A kind of Chinese prescription consists of the following composition, the Radix Astragali 30 weight portions, Radix Ginseng Rubra 15 weight portions, Rhizoma Polygonati 35 weight portions, Cortex Phellodendri 15 weight portions, Rhizoma Coptidis 15 weight portions, Radix Salviae Miltiorrhizae 20 weight portions, Fructus Lycii 15 weight portions, Radix Puerariae 20 weight portions, Radix Notoginseng 7.5 weight portions, wine army 5 weight portions, Fructus Schisandrae Chinensis 10 weight portions, Poria 20 weight portions, the Rhizoma Atractylodis Macrocephalae 15 weight portions.
Embodiment 4
A kind of Chinese prescription consists of the following composition, the Radix Astragali 28 weight portions, Radix Ginseng Rubra 17 weight portions, Rhizoma Polygonati 32 weight portions, Cortex Phellodendri 18 weight portions, Rhizoma Coptidis 16 weight portions, Radix Salviae Miltiorrhizae 18 weight portions, Fructus Lycii 12 weight portions, Radix Puerariae 22 weight portions, Radix Notoginseng 8 weight portions, wine army 6 weight portions, Fructus Schisandrae Chinensis 13 weight portions, Poria 16 weight portions, the Rhizoma Atractylodis Macrocephalae 18 weight portions, Hirudo 2 weight portions, Scorpio 2 weight portions.
Embodiment 5
A kind of Chinese prescription consists of the following composition, the Radix Astragali 32 weight portions, Radix Ginseng Rubra 12 weight portions, Rhizoma Polygonati 38 weight portions, Cortex Phellodendri 12 weight portions, Rhizoma Coptidis 12 weight portions, Radix Salviae Miltiorrhizae 14 weight portions, Fructus Lycii 18 weight portions, Radix Puerariae 18 weight portions, Radix Notoginseng 6 weight portions, wine army 4 weight portions, Fructus Schisandrae Chinensis 8 weight portions, Poria 22 weight portions, the Rhizoma Atractylodis Macrocephalae 12 weight portions, Hirudo 5 weight portions, Scorpio 5 weight portions.
Embodiment 6
A kind of Chinese prescription consists of the following composition, the Radix Astragali 30 weight portions, Radix Ginseng Rubra 15 weight portions, Rhizoma Polygonati 35 weight portions, Cortex Phellodendri 15 weight portions, Rhizoma Coptidis 15 weight portions, Radix Salviae Miltiorrhizae 20 weight portions, Fructus Lycii 15 weight portions, Radix Puerariae 20 weight portions, Radix Notoginseng 7.5 weight portions, wine army 5 weight portions, Fructus Schisandrae Chinensis 10 weight portions, Poria 20 weight portions, the Rhizoma Atractylodis Macrocephalae 15 weight portions, Hirudo 3.5 weight portions, Scorpio 3.5 weight portions.
Comparative example 1
A Chinese prescription for the treatment of diabetes, comprising: Radix Astragali 25g, Radix Ginseng Rubra 10g, Rhizoma Polygonati 25g, Cortex Phellodendri 10g, Rhizoma Coptidis 10g, Radix Salviae Miltiorrhizae 15g, Fructus Lycii 15g, Radix Paeoniae Rubra 10g, Radix Puerariae 15g, Radix Notoginseng 5g, the 3g of wine army, Fructus Schisandrae Chinensis 10g.
Embodiment 7
Male patient, 60 years old age
Head examines: mouth and nose are dry, occasionally has loose stool, diabetic history (FPG:9.3mmol/L), and pale tongue with thin fur is white, ectopia arteriae radialis.
Dispose: the every twice-daily of prescription in embodiment 1 for oral use, each 20, take surrounding.
Two examine: if lose loose stool, dryness in the nasal cavity is clearly better, FPG:7.3mmol/L, and pale tongue with thin fur is white, ectopia arteriae radialis.
Dispose: according to the state of an illness, adjust with two weeks amounts of embodiment 2 Chinese patent medicine particles dosage form, require patient's twice-daily oral, each 20.
Three examine: readme is without significant discomfort symptom, and different blood glucose levels is good, and FPG level fluctuates between 6.5-7.2.
Dispose: continuous with the oral curative effect of consolidating of granule dosage form in embodiment 2.
Embodiment 8
Male patient, 40 years old age
Head examines: weak, and diabetic history (FPG:8.7mmol/L, 2hPG:13.4mmol/L), light red tongue tongue is white, deep-thready pulse.
Dispose: this patient examines so that glycemic control is bad, and dialectical is syndrome of deficiency of both qi and yin, give two weeks amounts of granule in embodiment 3, twice-daily is oral, each 20.
Two examine: weak being clearly better, readme glycemic control good (FPG:7.1mmol/L, 2hPG:9.9mmol/L test oneself before examining), blood lipid level abnormal (TG:5.1u/L, LDL-C:1.2u/L), light red tongue white fur BOHUANG, thready pulse.
Dispose: give two weeks amounts of granule in embodiment 4 according to the state of an illness, twice-daily is oral, each 20.
Three examine: without significant discomfort main suit, different blood glucose levels is good, and FPG fluctuates between 6.9-7.4mmol/L, and blood lipid level also recovers normal level, and pale tongue with thin fur is white, thready pulse.
Dispose: continue and take with embodiment 4 prescriptions, after treatment.
Embodiment 9
Female patient, 42 years old
Head examines: fasting glucose 9.4mmol/L, red tongue is dark, indentations at the margin of the tongue, the few Tianjin of white and thin fur, thready and weak pulse.
Dispose: give granule surrounding amount in embodiment 5, twice-daily is oral, each 20.
Two examine: without significant discomfort, this time menorrhagia is abnormal in private prosecution, and fasting glucose is less than 7.
Dispose: granule in embodiment 6 is taken in change, consolidates.
Embodiment 10
Male patient, 53 years old age
Head examines: emaciated physique, and constipation with dry stool, easy sweating at night, light red tongue secretly lacks tongue, and arteries and veins is number slightly, fasting glucose 9.2mmol/L.
Dispose: take granule surrounding amount in embodiment 6, twice-daily is oral, each 20.
Two examine: sweating at night symptom obviously alleviates, and diet two is just normal, light red tongue HongShaoJin(SIC), and deep-thready pulse, blood sugar level control is good.
Embodiment 11
Adopt embodiment 1 ~ 6, the prescription in comparative example 1 is tested, and result is as follows:
Adopt required standard, gastric infusion, has obvious reducing effect to normal mouse blood sugar level; Alloxan model hyperglycemic rat, Rabbits ' Blood Sugar level, the high sugar of Mouse Kidney upper parathyrine are had to obvious reducing effect, but reduction effect in comparative example 1 is poor; Embodiment 1 ~ 6 all can make rabbit alloxan model hyperglycemia rabbit glucose tolerance curve obviously move down, and can obviously improve rabbit carbohydrate tolerance, also can promote rabbit insulin secretion under high sugared state; The pancreatic tissue damage that 4 ~ 6 pairs of alloxan of embodiment cause has good repair, and blood stasis situation is had clear improvement, and wherein the effect in embodiment 6 is the most outstanding.
Claims (5)
1. one kind is used for the treatment of the Chinese prescription of diabetes, it is characterized in that, described Chinese prescription comprises: the Radix Astragali 25 ~ 35 weight portions, Radix Ginseng Rubra 10 ~ 20 weight portions, Rhizoma Polygonati 30 ~ 40 weight portions, Cortex Phellodendri 10 ~ 20 weight portions, Rhizoma Coptidis 10 ~ 20 weight portions, Radix Salviae Miltiorrhizae 15 ~ 25 weight portions, Fructus Lycii 10 ~ 20 weight portions, Radix Puerariae 15 ~ 25 weight portions, Radix Notoginseng 5 ~ 10 weight portions, wine army 2 ~ 8 weight portions, Fructus Schisandrae Chinensis 5 ~ 15 weight portions, Poria 15 ~ 25 weight portions, the Rhizoma Atractylodis Macrocephalae 10 ~ 20 weight portions.
2. according to the Chinese prescription that is used for the treatment of diabetes described in claim 1, it is characterized in that, described Chinese prescription comprises: the Radix Astragali 30 weight portions, Radix Ginseng Rubra 15 weight portions, Rhizoma Polygonati 35 weight portions, Cortex Phellodendri 15 weight portions, Rhizoma Coptidis 15 weight portions, Radix Salviae Miltiorrhizae 20 weight portions, Fructus Lycii 15 weight portions, Radix Puerariae 20 weight portions, Radix Notoginseng 7.5 weight portions, wine army 5 weight portions, Fructus Schisandrae Chinensis 10 weight portions, Poria 20 weight portions, the Rhizoma Atractylodis Macrocephalae 15 weight portions.
3. according to the Chinese prescription that is used for the treatment of diabetes described in claim 1 or 2, it is characterized in that, described Chinese prescription also comprises: Hirudo 2 ~ 5 weight portions, Scorpio 2 ~ 5 weight portions.
4. according to the Chinese prescription that is used for the treatment of diabetes described in claim 3, it is characterized in that: in described Chinese prescription, Hirudo is that 3.5 weight portions, Scorpio are 3.5 weight portions.
5. the Chinese prescription that is used for the treatment of diabetes described in arbitrary according to claim 1 ~ 4, is characterized in that: also comprise requirement adjuvant, the dosage form of described Chinese prescription is granule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410287755.4A CN104013806B (en) | 2014-06-25 | 2014-06-25 | A kind of Chinese prescription for being used to treat diabetes |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410287755.4A CN104013806B (en) | 2014-06-25 | 2014-06-25 | A kind of Chinese prescription for being used to treat diabetes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104013806A true CN104013806A (en) | 2014-09-03 |
| CN104013806B CN104013806B (en) | 2017-08-25 |
Family
ID=51430989
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410287755.4A Active CN104013806B (en) | 2014-06-25 | 2014-06-25 | A kind of Chinese prescription for being used to treat diabetes |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104013806B (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104826014A (en) * | 2015-05-07 | 2015-08-12 | 杨宇峰 | Traditional Chinese medicine preparation for treating type-II diabetes and preparation method thereof |
| CN106389832A (en) * | 2016-08-31 | 2017-02-15 | 洪雅县瓦屋山药业有限公司 | Preparation method of radix coptidis deltoideae health care capsules beneficial for diabetes treatment |
| CN114009722A (en) * | 2021-10-29 | 2022-02-08 | 瑞纳康(北京)生物科技有限公司 | Lipid-lowering and stasis-removing konjac poria cocos fine powder and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5535011A (en) * | 1978-09-01 | 1980-03-11 | Maruho Kk | Preparation of novel substance inhibiting formation and storage of lipid |
| CN1583014A (en) * | 2004-06-11 | 2005-02-23 | 辽宁中医学院药业有限公司 | Composite Chinese medicine for non-insulin dependent diabete and its preparation |
| CN101401908A (en) * | 2008-11-12 | 2009-04-08 | 辽宁中医药大学 | Traditional Chinese medicine for reducing blood sugar, governing blood fat and anti-DNA damnification, and preparation method thereof |
-
2014
- 2014-06-25 CN CN201410287755.4A patent/CN104013806B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5535011A (en) * | 1978-09-01 | 1980-03-11 | Maruho Kk | Preparation of novel substance inhibiting formation and storage of lipid |
| CN1583014A (en) * | 2004-06-11 | 2005-02-23 | 辽宁中医学院药业有限公司 | Composite Chinese medicine for non-insulin dependent diabete and its preparation |
| CN101401908A (en) * | 2008-11-12 | 2009-04-08 | 辽宁中医药大学 | Traditional Chinese medicine for reducing blood sugar, governing blood fat and anti-DNA damnification, and preparation method thereof |
Non-Patent Citations (3)
| Title |
|---|
| 刘冰: "《中西医论治糖尿病》", 31 October 1994, 河南科学技术出版社 * |
| 崔云竹: "程益春教授治疗糖尿病经验", 《长春中医药大学学报》 * |
| 赖祥林等: "《糖尿病方术优选》", 31 October 2007, 广东科技出版社 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104826014A (en) * | 2015-05-07 | 2015-08-12 | 杨宇峰 | Traditional Chinese medicine preparation for treating type-II diabetes and preparation method thereof |
| CN104826014B (en) * | 2015-05-07 | 2018-12-07 | 杨宇峰 | A kind of Chinese materia medica preparation and preparation method thereof for treating diabetes B |
| CN106389832A (en) * | 2016-08-31 | 2017-02-15 | 洪雅县瓦屋山药业有限公司 | Preparation method of radix coptidis deltoideae health care capsules beneficial for diabetes treatment |
| CN114009722A (en) * | 2021-10-29 | 2022-02-08 | 瑞纳康(北京)生物科技有限公司 | Lipid-lowering and stasis-removing konjac poria cocos fine powder and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104013806B (en) | 2017-08-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101559195B (en) | Epilepsy therapy capsule and preparation method thereof | |
| CN103705866A (en) | Traditional Chinese medicine composition for treating hypomenorrhea | |
| CN101543621B (en) | Drug for curing diabetes | |
| CN103816428A (en) | Preparation for effectively treating diabetes mellitus | |
| CN101366903B (en) | Traditional Chinese medicine composition for treating climacteric syndrome | |
| CN101199796B (en) | External antidiarrhoeal medicament, preparing method and function thereof | |
| CN104013806A (en) | Traditional Chinese medicine composition for treating diabetes mellitus | |
| CN103301355A (en) | Preparation method of chronic renal failure colon dialysate | |
| CN103432330B (en) | Traditional Chinese medicine used for treating renal failure and preparation method thereof | |
| CN104147526A (en) | Traditional Chinese medicine particles for treating icteric hepatitis and preparation method thereof | |
| CN103800689A (en) | Traditional Chinese medicine composition for treating diabetes mellitus | |
| CN1181833C (en) | Instant hypoglycemic medicine | |
| CN108452160A (en) | A kind of ginseng stilbene Siberian cocklebur art preparation of breath in heptan training pancreas therapy treatment diabetes | |
| CN103263595A (en) | Traditional Chinese medicine composition for treating diabetes | |
| CN103263580A (en) | Traditional Chinese medicine composition for treating diabetes | |
| CN103494939A (en) | Traditional Chinese medicine for treating senile habitual constipation | |
| CN100998720B (en) | Oral traditional Chinese medicine for treating amenorrhea of uterus stasis | |
| CN100998750A (en) | Oral traditional Chinese medicine for treating viral myocarditis of yin deficiency and blood stasis type | |
| CN105641594A (en) | Medicine for treating diabetes | |
| CN105381333A (en) | Traditional Chinese medicine composition with effects of treating spleen-kidney Yang deficiency | |
| CN104352771A (en) | Traditional Chinese medicine preparation for treating diabetes | |
| CN104415226A (en) | Liquid medicine for treating diabetes | |
| CN104666721A (en) | Medicinal composition for treating acne | |
| CN104771739A (en) | Traditional Chinese medicine composition for treating climacteric syndrome | |
| CN103110807B (en) | Medicine for treating diabetes |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20200116 Address after: Huanggu District of Shenyang City, 110000 East Road, located in Liaoning province No. 79 Patentee after: LIAONING University OF TRADITIONAL CHINESE MEDICINE Address before: 110000 2-3-5, Ning Shanxi Road, Huanggu District, Liaoning, Shenyang, 15 Patentee before: Shi Yan |
|
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20231019 Address after: 110000 No.33 Beiling Street, Huanggu District, Shenyang City, Liaoning Province Patentee after: FIRST AFFILIATED HOSPITAL OF LIAONING University OF TRADITIONAL CHINESE MEDICINE Address before: No.79, Chongshan East Road, Huanggu District, Shenyang, Liaoning 110000 Patentee before: LIAONING University OF TRADITIONAL CHINESE MEDICINE |
|
| TR01 | Transfer of patent right |