CN104352771A - Traditional Chinese medicine preparation for treating diabetes - Google Patents

Traditional Chinese medicine preparation for treating diabetes Download PDF

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CN104352771A
CN104352771A CN201410637740.6A CN201410637740A CN104352771A CN 104352771 A CN104352771 A CN 104352771A CN 201410637740 A CN201410637740 A CN 201410637740A CN 104352771 A CN104352771 A CN 104352771A
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高小娜
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
    • A61K36/605—Morus (mulberry)
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815—Lycium (desert-thorn)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/894—Dioscoreaceae (Yam family)
    • A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8969—Polygonatum (Solomon's seal)
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    • A61K9/00—Medicinal preparations characterised by special physical form
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    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

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Abstract

The invention discloses a traditional Chinese medicine preparation for treating diabetes. The preparation is characterized by being prepared from the following selected raw traditional Chinese medicinal materials in parts by weight: 25 parts of America ginseng, 18 parts of Chinese yams, 15 parts of burdocks, 25 parts of radix polygonati officinalis, 15 parts of mulberries, 30 parts of astragalus membranaceus, 30 parts of black soya beans, 25 parts of wolfberry, 25 parts of glossy privet fruits and 12 parts of poria cocos. As the selected raw traditional Chinese medicinal materials are complementary in property and effect, mutual inhibition, mutual restraint and mutual detoxication among medicines are avoided, so that the effects of mutual reinforcement and mutual assistance are obvious, and thus, the preparation plays a role of enhancing the immunity. The preparation has the functions of enriching yin and nourishing kidney, nourishing blood and tonifying essence and invigorating spleen and supplementing qi and is the preparation prepared from internally taken pure Chinese herbal medicines for treating diabetes.

Description

The Chinese medicine preparation for the treatment of diabetes
Technical field
The present invention relates to field of traditional Chinese, be specifically related to a kind of Chinese medicine preparation being used for the treatment of diabetes, there are enriching yin and nourishing kidney, nourish blood should essence, invigorating the spleen and benefiting QI effect.
Background technology
The metabolic disease of diabetes to be one group with hyperglycemia be feature.Hyperglycemia be then due to defect of insulin secretion or its biological agent impaired, or both have concurrently and cause.Long-standing hyperglycemia during diabetes, causes various tissue, particularly eye, kidney, heart, blood vessel, neural chronic lesion, dysfunction.The cause of disease of diabetes is caused to have two kinds: 1. inherited genetic factors: 1 type or type 2 diabetes mellitus all exist obvious genetic heterogeneity.There is family's morbidity tendency in diabetes, 1/4 ~ 1/2 patient has Diabetes family history.Have at least the genetic syndrome of more than 60 kinds can with diabetes clinically.Type 1 diabetes has multiple DNA site to participate in morbidity, wherein close with DQ loci polymorphism relation in HLA antigen gene.Multiple clear and definite gene mutation has been found, as insulin gene, insulin receptor gene, glucokinase gene, mitochondrial gene etc. at type 2 diabetes mellitus.2. environmental factors: too much, it is the topmost environmental factors of type 2 diabetes mellitus that physical exertion reduces the obesity caused, and the individuality with type 2 diabetes mellitus genetic predisposition is easily fallen ill in feed.There is immune system abnormality in type 1 diabetes patient, in some virus as Coxsackie virus, rubella virus, parotid gland virus etc. cause autoimmune response after infecting, and destroy insulin β cell.Main clinical manifestation: 1. polydipsia, polyuria, polyphagia and become thin.2. fatigue and weak, fat.
Summary of the invention:
The object of the present invention is to provide a kind of Chinese medicine preparation being used for the treatment of diabetes, there are enriching yin and nourishing kidney, nourish blood should essence, invigorating the spleen and benefiting QI effect.
Present invention employs following technical scheme for achieving the above object: the medical material that Chinese medicine preparation of the present invention is selected and weight portion respectively: Radix Panacis Quinquefolii 25 parts, Rhizoma Dioscoreae 18 parts, Fructus Arctii 15 parts, Rhizoma Polygonati Odorati 25 parts, 15 parts, Fructus Mori, the Radix Astragali 30 parts, 30 parts, Semen sojae atricolor, Fructus Lycii 25 parts, Fructus Ligustri Lucidi 25 parts, 12 parts, Poria.
In the raw material of Chinese medicine that the present invention selects: Radix Panacis Quinquefolii: the dry root of Araliaceae Radix Panacis Quinquefolii Panaxquinquefolium L..[meridian distribution of property and flavor] sweet, micro-hardship, cool.GUIXIN, lung, kidney channel.[function cures mainly] boosting qi and nourishing yin, clearing away heat and promoting production of body fluid.Lose for deficiency of vital energy the moon, interior-heat, cough with asthma expectorant blood, deficiency-heat is tired of tired, quenches one's thirst, dryness of the mouth and throat.Radix Panacis Quinquefolii has the effect of resisting fatigue, antioxidation, anti-stress, anticoagulant, reduction blood coagulability, in addition, diabetics is also had to the effect regulating blood glucose.
Rhizoma Dioscoreae: have and nourish strong, aid digestion, hold back sweating due to debility, effect of antidiarrheal, cure mainly insufficiency of the spleen diarrhoea, cough due to deficiency of the lung, diabetes are quenched one's thirst, oliguria frequently, road essence, women's leukorrhagia and dyspeptic chronic enteritis.Nature and flavor: sweet, flat, nontoxic.Gui Jing: return spleen, lung, kidney channel.Function: spleen reinforcing nourishing the stomach, promote the production of body fluid lung benefiting, the kidney invigorating arresting seminal emission.For insufficiency of the spleen lack of appetite, incessant chronic diarrhea, the deficiency of the lung is breathed with cough, emission due to deficiency of the kidney, leukorrhagia, frequent micturition, and deficiency-heat is quenched one's thirst.Rhizoma Dioscoreae (parched with bran) spleen reinforcing stomach invigorating.For insufficiency of the spleen lack of appetite, loose stool of having loose bowels, leukorrhagia.
Fructus Arctii: be the dry mature fruit of Compositae biennial herb plant Fructus Arctii (formal name used at school: Arctium lappa L.).There is dispelling wind and heat pathogens, lung qi dispersing rash, sore-throat relieving eliminating stagnation, effect of removing toxic substances and promoting subsidence of swelling.Belong to wind-heat-dispersing medicinal in diaphoretic medicine.Modern study, Fructus Arctii also can be used for preventing and treating diabetic nephropathy; The arctigenin that Arctium lappa fruit generates through hydrolysis containing arctigenin has active anticancer.
Rhizoma Polygonati Odorati: function cures mainly: yin nourishing, moisturizes, and relieving restlessness is quenched the thirst.Control calentura the moon wound, cough excessive thirst, deficient fever, rapid digestion of food is easily hungry, frequent micturition, the diseases such as heart disease, diabetes, tuberculosis; Tool yin nourishing, moisturize, heat clearing away, promote the production of body fluid, the effect such as cough-relieving.Root stock contains Rhizoma Polygonati Odorati mucopolysaccharide (odoratan), by D-Fructose, and D-MANNOSE, D-Glucose and galacturonic acid formed, and mol ratio is 6:3:1:1.5; Rhizoma Polygonati Odorati levan (polygonatum-fructan) A, B, C, D, sugared consists of fructose (%): glucose (%) (97.5:2.6,96.2:3.8,95.3:4.8,90.4:9.6), AzeOH (azetidine-2-carboxylic acid).Also containing Rhizoma Polygonati spiral shell sterol (polyspirostanol) Poa, Rhizoma Polygonati spiral shell sterol glycoside (poly-spirostanoside) Pob, Poc, P01, P02, P03, P04, P05, Rhizoma Polygonati furan sterol glycoside (polyfuroside), the steroids such as Rhizoma Polygonati furan sterol glycoside Poc, Pod, P06, P07, P08 and P09.P02 and Pob has identical structure, is 25-R, S three-dimensional heterogeneous mixture, and just R/S ratio is different; P03 is the mixture of Poc extremely 25-R.
Fructus Mori: [nature and flavor] are sweet; Acid; Cold in nature; [return through] liver; Kidney channel.[effect] nourishing YIN and supplementing blood, promote the production of body fluid moisturize, intestine moistening toxin expelling.[effect classification] nourishing YIN and benefiting blood medicine; Promote the production of body fluid medicine; Aperitive.Having a dizzy spell of [curing mainly] deficiency of the liver and kindey and blood deficiency damage of essence; Soreness of waist tinnitus; Early whitening of beard and hair; Insomnia and dreamful sleep; Tianjin wound is thirsty; Quench one's thirst; Dryness of the intestine constipation.Chemical composition: Fructus Mori are sugary, protein, fat, acid of mixing, malic acid and vitamin A, vitamin B1, vitamin B2, vitamin C, ferrum, sodium, calcium, magnesium, phosphorus, potassium, carotene and anthocyanidin.The fatty acid of Fructus Mori oil is primarily of compositions such as linoleic acid and a small amount of stearic acid, oleic acid.
The Radix Astragali: have 1, an exterior deficiency spontaneous perspiration, is used for the weak caused spontaneous perspiration of body void table.2, night sweat due to yin deficiency; 3, acute nephritis edema, for the void edema caused by YANG QI deficiency; 4, oedema due to chronic nephritis, spleen person who suffer from deficiency of kidney Yang; 5, yang-energy is weak, caves in, have and promote diabrosis and limitation effect for skin infection not diabrosis for a long time.6, skin infection is burst for a long time and is not healed, and after skin infection diabrosis, does not close up for a long time, has the effect of promoting tissue regeneration and wound healing; 7, syndrome of deficiency of spleen qi, weak asthenia, has loose bowels, sinking of QI of middle-JIAO, and internal organs prolapse, the indigestion and loss of appetite all diseases of lack of appetite.8, syndrome of deficiency of lung qi.With the passing of time, shortness of breath and tired spirit, expectorant harmony brings up in lung is unable cough with asthma.9, hyperhidrosis and edema.10, weak for the deficiency of vital energy, fatigue and weakness, or sinking of QI of middle-JIAO, proctoptosis, uterine prolapse.Nature and flavor: sweet, tepor.Gui Jing: return lung, spleen, liver, kidney channel; Have enhancing human body immunity function, protect the liver, diuresis, defying age, anti-stress, blood pressure lowering and antibacterial action more widely.
Semen sojae atricolor: property is flat, sweet in the mouth; Return spleen, kidney channel; Have that the detumescence therapeutic method to keep the adverse QI flowing downwards, lung moistening are scorching, activating blood and promoting diuresis, wind expelling stagnation removing, blood-enriching tranquillizing, improving eyesight spleen invigorating, the kidney invigorating tonifying YIN, removing toxic substances effect; For edema distension, pathogenic wind-toxic beriberi, jaundice edema, migratory arthralgia spasm, puerperal exposure to wind pain, locked mouth, carbuncle sore tumefacting virus, poison of drug can be separated, wind heat processed and only night sweat, the function of black hair hair color and life lengthening.
Fructus Lycii: [nature and flavor] are sweet is flat.[return through] returns liver, kidney channel.[function cures mainly] nourishing the liver and kidney, replenishing vital essence to improve eyesight.For asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, and blurred vision is failed to understand.
Fructus Ligustri Lucidi: nature and flavor: sweet is bitter, flat.Gui Jing: liver; Kidney channel; Effect is classified: tonic.Effect: liver and kidney tonifying, clearind deficient heat, strong waist knee joint, improve visual and auditory acuity, black beard and hair.Cure mainly: Light-headedness; Soreness of the waist and knees; Seminal emission; Tinnitus; Early whitening of beard and hair, osteopyrexia and fever.
Poria: property slightly sweet flavor is put down, and enters the heart, lung, spleen channel.There is eliminating dampness and diuresis, invigorating the spleen and regulating the stomach, effect of mind tranquilizing and the heart calming.Energy enhancing human body immunity function, pachyman has obvious antitumor and protects the liver dirty effect.Can control dysuria, edema distension, phlegm retention cough with dyspnea, vomiting, malignant histocytosis, has loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, forgetful disease such as grade.
Raw medicinal material property of medicine effect selected by the present invention is complementary, has evaded the choosing of the mutual inhibition of compatibility between medicine, mutual restraint between two drugs, the mutual-detoxication, makes medicine mutual reinforcement between, mutual-assistance effect significantly, has the effect of enhancing immunity.There are enriching yin and nourishing kidney, nourish blood should essence, invigorating the spleen and benefiting QI effect, be that for oral administration pure Chinese herbal medicine for the treatment of diabetes forms preparation.There is during clinical practice good precise effects.
Medicine of the present invention can adopt the conventional method of Chinese medicine preparation to be prepared into any conventional oral preparations.Such as these crude drug pulverize mix homogeneously powder can be taken after mixing it with water; Can by these crude drug together decocting, then concentrated decocting liquid is taken, or concentrated decocting liquid is condensed into cream is processed into pill and takes; In order to make each raw material of this medicine play drug effect better, carry out special extraction for certain crude drug, as ethanol extraction, these can not be used for limiting the scope of the invention.
Medicine of the present invention has enriching yin and nourishing kidney, nourish blood effect of suitable essence, invigorating the spleen and benefiting QI, is used for the treatment of diabetes.The present inventor through repeatedly studying, and passes through the checking repeatedly of clinical trial, finally have found the endo-medicine of better curative effect, thus completes the present invention.
Clinical test of pesticide effectiveness material and model case:
1. room XX, man, 49 years old.November 7 2006 first visit date.Patient finds lean body mass spring in 2006, and general fatigue is unable, and waist knee joint is aching and tired, polyuria, and mouth is yearningly micro-, and food is received general.In 9 also at certain hospital admission, be diagnosed as diabetes.Once took more than Western medicine January, curative effect is not obvious, asks Chinese traditional treatment.Patient's emaciated physique, it is soft that waist is stranded lower limb, frequent micturition, pale tongue, white and thin fur, deep-thready pulse.Disappear under this genus deficiency of the kidney yin causes into.Control and should YIN nourishing reinforce the kidney.After taking we 20 doses, conscious whole body is comparatively front strong, and urine volume number of times reduces, and still has waist to be stranded.After continuing to take we 35 doses, body weight increases to some extent, and all diseases disappear.Continue to take we 20 doses, consolidated.
Method and effective dose: Radix Panacis Quinquefolii 25 parts, Rhizoma Dioscoreae 18 parts, Fructus Arctii 15 parts, Rhizoma Polygonati Odorati 25 parts, 15 parts, Fructus Mori, the Radix Astragali 30 parts, 30 parts, Semen sojae atricolor, Fructus Lycii 25 parts, Fructus Ligustri Lucidi 25 parts, 12 parts, Poria; Get prescription ormal weight tcm and herbal slice, put in suitable decocting device, add clear water appropriate, soak suitable time, be heated to boil, keep slight boiling condition certain hour (about 25 ~ 30 minutes), be separated fried liquid, medicinal residues add water and decoct in right amount, after regulation decoction 2 ~ 3 times, merge fried liquid, filter or settlement separate fried liquid for.
Decoction oral is main, and every day takes orally for 2 times sooner or later, each 150ml decoction being taken warmly.Decoction then acts on fast and power is high, is adapted to the more anxious severe one of the state of an illness.As lighter in the state of an illness or slow person, is preferably that pill is for oral administration asks its merit.
Detailed description of the invention
The described Chinese medicine preparation being used for the treatment of diabetes, it is characterized in that, the raw material of Chinese medicine of selection and weight portion respectively: Radix Panacis Quinquefolii 25 parts, Rhizoma Dioscoreae 18 parts, Fructus Arctii 15 parts, Rhizoma Polygonati Odorati 25 parts, 15 parts, Fructus Mori, the Radix Astragali 30 parts, 30 parts, Semen sojae atricolor, Fructus Lycii 25 parts, Fructus Ligustri Lucidi 25 parts, 12 parts, Poria;
Preparation method: get Radix Panacis Quinquefolii 25 parts, Rhizoma Dioscoreae 18 parts, Fructus Arctii 15 parts, Rhizoma Polygonati Odorati 25 parts, 15 parts, Fructus Mori, the Radix Astragali 30 parts, 30 parts, Semen sojae atricolor, Fructus Lycii 25 parts, Fructus Ligustri Lucidi 25 parts, 12 parts, Poria; Make decoction pieces respectively, put in suitable decocting device, add clear water appropriate, soak suitable time, be heated to boil, keep slight boiling condition certain hour (about 25 ~ 30 minutes), be separated fried liquid, medicinal residues add water and decoct in right amount, after regulation decoction 2 ~ 3 times, merge fried liquid, filter or settlement separate fried liquid for.

Claims (1)

1. be used for the treatment of the Chinese medicine preparation of diabetes, it is characterized in that, the raw material of Chinese medicine of selection and weight portion respectively: Radix Panacis Quinquefolii 25 parts, Rhizoma Dioscoreae 18 parts, Fructus Arctii 15 parts, Rhizoma Polygonati Odorati 25 parts, 15 parts, Fructus Mori, the Radix Astragali 30 parts, 30 parts, Semen sojae atricolor, Fructus Lycii 25 parts, Fructus Ligustri Lucidi 25 parts, 12 parts, Poria;
Its preparation method: get Radix Panacis Quinquefolii 25 parts, Rhizoma Dioscoreae 18 parts, Fructus Arctii 15 parts, Rhizoma Polygonati Odorati 25 parts, 15 parts, Fructus Mori, the Radix Astragali 30 parts, 30 parts, Semen sojae atricolor, Fructus Lycii 25 parts, Fructus Ligustri Lucidi 25 parts, 12 parts, Poria; Make decoction pieces respectively, put in suitable decocting device, add clear water appropriate, soak suitable time, be heated to boil, keep slight boiling condition certain hour (about 25 ~ 30 minutes), be separated fried liquid, medicinal residues add water and decoct in right amount, after regulation decoction 2 ~ 3 times, merge fried liquid, filter or settlement separate fried liquid for.
CN201410637740.6A 2014-10-31 2014-10-31 Traditional Chinese medicine preparation for treating diabetes Pending CN104352771A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108421012A (en) * 2017-02-14 2018-08-21 景金发 Hypoglycemic promotes the production of body fluid soup

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108421012A (en) * 2017-02-14 2018-08-21 景金发 Hypoglycemic promotes the production of body fluid soup

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