CN103127472A - Traditional Chinese medicine compound for refractory insomnia - Google Patents
Traditional Chinese medicine compound for refractory insomnia Download PDFInfo
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- CN103127472A CN103127472A CN2013100944121A CN201310094412A CN103127472A CN 103127472 A CN103127472 A CN 103127472A CN 2013100944121 A CN2013100944121 A CN 2013100944121A CN 201310094412 A CN201310094412 A CN 201310094412A CN 103127472 A CN103127472 A CN 103127472A
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Abstract
The invention discloses a traditional Chinese medicine compound for refractory insomnia, which comprises the following components according to certain weight ratio: dried rehmannia root, radix asparagi, radix ophiopogonis, spina date seed, platycladi seed, radix scrophulariae, salvia miltiorrhiza, cortex moutan, gardenia, radix bupleuri, chinese angelica, white paeony root, poria, radix curcumae, caulis polygoni multiflori, mother of pearl and dens draconis. The traditional Chinese medicine compound has the effects of removing heat to cool blood, promoting the secretion of saliva or body fluid and tranquilizing mind by nourishing heat, thus being capable of treating refractory insomnia effectively.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, be specifically related to a kind of Chinese medicine composition for intractable insomnia.
Background technology
Insomnia is not enough with the length of one's sleep, Depth of sleep not and can not allaying tiredness, to regain one's strength with energy be the disease of principal character.The course of disease above person half a year is intractable insomnia.Intractable insomnia be mainly due to the insomniac fall asleep front to fall asleep, the irritated emotional response of the phenomenon such as sound interference, early awakening and excessive anxiety, intense strain cause when sleep quality, sleep.Intractable insomnia is referred to as " being insomnia ", " insomnia ", " must not crouch ", " unable to close the eyes " in traditional Chinese medical science ancient books, be common clinical, frequently-occurring disease.This course of disease is long, and normal touching difficulty heals, thereby causes spirit and sensual very big misery to the patient.Along with the quickening of people's rhythm of life, this sick sickness rate is in rising trend, is having a strong impact on patient's work and quality of life.Western medicine adopts calmness, hypnosis and antianxiety drugs treatment more, and therapeutic effect is not good, and can not life-time service.Compare with Western medicine, Chinese medicine has stable curative effect to the treatment of intractable insomnia, the advantage that toxic and side effects is little.In the treatment of the intractable insomnia especially of having a sleepless night, Chinese medicine plays an important role.
Summary of the invention
The purpose of this invention is to provide a kind of Chinese medicine composition, this Chinese medicine composition has good effect for intractable insomnia, the characteristics that have no side effect.
The present invention selects Radix Rehmanniae, Radix Asparagi, Radix Ophiopogonis, Semen Ziziphi Spinosae, Semen Platycladi, Radix Scrophulariae, Radix Salviae Miltiorrhizae, Cortex Moutan, Fructus Gardeniae, Radix Bupleuri, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Poria, Radix Curcumae, Caulis Polygoni Multiflori, Concha Margaritifera, Dens Draconis to make up, make each efficacy of drugs produce synergism these drug regimens, make it to have clearing away heat and cooling blood, the YIN nourishing of promoting the production of body fluid, the effect of tranquilizing by nourishing the heart, thus intractable insomnia can effectively be treated.
The effect of Chinese medicine of the present invention:
Wherein:
Radix Rehmanniae: be the root of dicotyledon medicine scrophulariaceae rehmannia glutinosa plant or bosom celebrating Radix Rehmanniae.Nature and flavor are sweet, bitter, and are cool.Enter the heart, liver, kidney channel.Effect: heat clearing away is nourished blood, the YIN nourishing of promoting the production of body fluid.Radix Rehmanniae has obvious sedation, and its site of action is at cerebral cortex, and its aqueous extract can suppress autonomic activities, and can strengthen the syngignoscism of HD pentobarbital sodium and penthiobarbital, also can resist the excitation of caffeine and sodium benzoate simultaneously.
Radix Asparagi: be the tuber of liliaceous plant Radix Asparagi (Radix Asparagi).Nature and flavor are cold, and are sweet, little hardship.Return lung, kidney, stomach warp.Effect: nourshing Yin and drynsessmoistening prescription; Lung heat clearing is promoted the production of body fluid, and calms the nerves." Japan hanako materia medica ": relieving palpitation, moistening five ZANG-organs, beneficial skin, improving healthy complexion is mended five kinds of strain and seven kinds of impairment, controls lung qi and coughs, expectorant, migratory arthralgia pyretic toxicity, urticaria, the unhappy haematemesis.
Radix Ophiopogonis: be the dried root of liliaceous plant Ophiopogon Radix Ophiopogonis japonicus (Thunb.) Ker-Gawl..Nature and flavor are sweet, little hardship, are slightly cold.GUIXIN, lung, stomach warp.Effect: YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.Radix Ophiopogonis, decoct had sedation to the central nervous system, also can strengthen the sedation of chlorpromazine, strengthened the syngignoscism of pentobarbital sodium.
Semen Ziziphi Spinosae: be the seed of Rhamnaceae plant Ziziphi Spinosae.Nature and flavor are sweet, sour, and are flat.GUIXIN, spleen, liver, gallbladder meridian.Effect: nourishing the liver, mind calming is calmed the nerves, arresting sweating.The calmness of Semen Ziziphi Spinosae water solubility extract, hypnosis, anticonvulsant action.
Semen Platycladi: be the dry mature kernal of Cupressaceae plant Cacumen Platycladi Platycladus orientalis (L.) Franco.Nature and flavor are sweet, and are flat.GUIXIN, kidney, large intestine channel.Effect: tranquilizing by nourishing the heart, loosening bowel to relieve constipation.Semen Platycladi has calmness, syngignoscism.Shennong's Herbal: " cypress is real, and sweet in the mouth is flat, main palpitation with fear, and settling five organs, QI invigorating, except rheumatism numbness, clothes make us moist, beauty, normal hearing and eyesight for a long time.”
Radix Scrophulariae: be the dry root of dicotyledon Scrophulariaceae Scrophulariaceae Radix Scrophulariae Scrophularia ningpoensisHemsl..Nature and flavor are sweet, bitter, salty, are slightly cold.Return lung, stomach, kidney channel.Effect: clearing away heat and cooling blood, eliminating fire and detoxication, YIN nourishing." medicine origin ": control that the regretful Nang of the heart is tired and insomnia is wild utterly confused, the stasis dysuria.
Radix Salviae Miltiorrhizae: be the dry root and rhizome of dicotyledon Labiatae Labiatae salvia Radix Salviae Miltiorrhizae Salvia miltiorrhiza Bge..Nature and flavor are bitter, are slightly cold.Enter the heart, Liver Channel.Effect: promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, removing heat from blood eliminating carbuncle, the relieving restlessness that clears away heart-fire, nourishing blood to tranquillize the mind." the southern regions of the Yunnan Province book on Chinese herbal medicine ": reinforcing the heart sedate, calming heart and tranquilizing mind.Control forgetful punching seized with terror, palpitation with fear is insomnia.
Cortex Moutan: be the dry root bark of ranunculaceae peony Paeonia suffruticosa Andr..Nature and flavor are bitter, hot, are slightly cold.GUIXIN, liver, kidney channel.Effect: clearing away heat and cooling blood; Promoting blood circulation to remove blood stasis.Paeonol can hypnotic and convulsion to the central nervous system.
Fructus Gardeniae: be the dry mature fruit of Maguireothamnus speciosus Fructus Gardeniae ardenia jasminoides Ellis.Nature and flavor are bitter, and are cold; Nontoxic.GUIXIN, liver, lung, stomach, tri-jiao channel.Effect: pathogenic fire purging relieving restlessness; Clearing away heat-damp and promoting diuresis; Removing pathogenic heat from blood and toxic substance from the body.The composition such as Fructus Gardeniae and contained iridoid glycoside all has choleretic effect, and the Fructus Gardeniae alcohol extract can reduce spontaneous activity, has sedation, and with ciclobarbital soluble, synergism is arranged, and can extend the length of one's sleep, can resist the convulsions of pentetrazole." medicine class on the analogy of natural things ": control vexed annoyance, tired insomnia, wild utterly confused, blood band, dysuria.
Radix Bupleuri: be dry root or the herb of umbelliferae bupleurum or Radix Bupeuri Scorzonerfolii..Nature and flavor are slightly cold, hardship, suffering.Return liver, lung, spleen channel.Effect: expelling pathogenic factors from the exterior expels the heat-evil, dispersing the stagnated live-QI to relieve the stagnation of QI, elevate a turnable ladder yang-energy." medicineization justice ": Radix Bupleuri, property is gently clear, and main liter is loose, and mildly bitter flavor is main soothing the liver.
Radix Angelicae Sinensis: be the dry root of umbelliferae angelica Angelica sinensis (Oliv.) Diels.Nature and flavor are sweet, hot, bitter, temperature.Return liver, the heart, spleen channel.Effect: enrich blood; Invigorate blood circulation; Menstruction regulating and pain relieving; Moisturize laxation.Radix Angelicae Sinensis volatile oil has the effects such as calmness, hypnosis, analgesia, anesthesia to the central nervous system.
The Radix Paeoniae Alba: be the root of dicotyledon medicine ranunculaceae plant Radix Paeoniae (cultigen).Nature and flavor are bitter, sour, cool.Return liver, spleen channel.Effect: nourishing blood to suppress the hyperactive liver, slow middle pain relieving, yin fluid astringing is received antiperspirant.Paeoniflorin has spasmolysis and analgesic activity preferably." medicine origin ": " the peace spleen channel is controlled stomachache, receives gastric qi, antidiarrheal profit, and blood, fixing striae, eliminating pathogen in the liver, tonifying the spleen and stomach."
Poria: be the dry sclerotia of On Polyporaceae Poria Poria cocos (Schw.) Wolf.Nature and flavor are sweet, light, and are flat.GUIXIN, lung, spleen, kidney channel.Effect: eliminating dampness and diuresis, invigorating the spleen and regulating the stomach, mind tranquilizing and the heart calming.The Poria decoct has obvious sedation." modality ": " cure mainly the Ji Rou Shun muscle of throbbing with fear cautious, the dizziness agitation is controlled on the side.”
Radix Curcumae: be the dried root of zingiberaceous plant RADIX CURCUMAE Curcuma wenyujin Y. H. Chen et C. Ling, Rhizoma Curcumae Longae Curcuma longa L., Guangxi zedoary Curcuma kwangsiensis S. G. Lee et C. F. Liang or Rhizoma Curcumae Curcuma phaeocaulis Val..Nature and flavor are hot, bitter, and are cold.Return liver, the heart, lung meridian.Effect: promoting blood circulation and stopping pain, promoting QI circulation for relieving depression, the removing heat from blood that clears away heart-fire, promoting the function of the gallbladder to alleviate jaundice.
Caulis Polygoni Multiflori: be rattan or the leaf bine stem of dicotyledon medicine polygonum multiflorum thunb.Nature and flavor are sweet, little hardship, and are flat.Enter the heart, spleen, kidney, Liver Channel.Effect: nourish heart, calm the nerves, collateral dredging dispels the wind.The complex acid Semen Ziziphi Spinosae is grown the heart-yin, mind calming god; Join the Radix Rehmanniae, the nourishing YIN of nourishing blood; Join Radix Asparagi, Radix Ophiopogonis, clear asthenic fire, the moon nourishes heart.
The shell of Concha Margaritifera: Pteriidae animal Pteria martensii Dunker Pteria martensii (Dunker), Unionidae animal hydriopsis cumingii Hyriopsis cumingii (Lea) or cristaria plicata Cristaria plicata (Leach).Nature and flavor are salty, cold.Return liver, heart channel.Effect: suppressing the hyperactive liver and subsiding YANG, calm the nerves, calming the frightened makes eye bright.Maincenter to pentobarbital sodium suppresses to have obvious synergism.
Dens Draconis: for ancient times mammal as if the fossil of the tooth of class, rhinoceros class, Hippocampal cortex etc.Nature and flavor are puckery, sweet, and are cool.GUIXIN, Liver Channel.Function: tranquillizing the mind by relieving convulsion; Clearing heat and relieving fidgetness." property of medicine opinion ": relieving palpitation, peace soul.
Medicine material consumption of the present invention is groped to sum up to draw through the inventor in a large number, and each raw material consumption is for all to have curative effect preferably in the following weight parts scope: Radix Rehmanniae 55-65 part, Radix Asparagi 10-20 part, Radix Ophiopogonis 10-20 part, Semen Ziziphi Spinosae 25-35 part, Semen Platycladi 7-17 part, Radix Scrophulariae 10-20 part, Radix Salviae Miltiorrhizae 20-28 part, Cortex Moutan 7-17 part, Fructus Gardeniae 5-15 part, Radix Bupleuri 4-14 part, Radix Angelicae Sinensis 7-17 part, Radix Paeoniae Alba 20-28 part, Poria 10-20 part, Radix Curcumae 5-15 part, Caulis Polygoni Multiflori 25-35 part, Concha Margaritifera 45-55 part, Dens Draconis 45-55 part.
Wherein be preferably: 60 parts of Radix Rehmanniae, 15 parts of Radix Asparagis, 15 parts of Radix Ophiopogonis, 30 parts of Semen Ziziphi Spinosaes, 12 parts of Semen Platycladi, 15 parts of Radix Scrophulariaes, 24 parts of Radix Salviae Miltiorrhizaes, 12 parts of Cortex Moutans, 10 parts of Fructus Gardeniaes, 9 parts of Radix Bupleuri, 12 parts of Radix Angelicae Sinensis, 24 parts of the Radix Paeoniae Albas, 15 parts, Poria, 10 parts of Radix Curcumaes, 30 parts of Caulis Polygoni Multiflori, 50 parts of Concha Margaritiferas, 50 parts of Dens Draconiss.
Medicine of the present invention can adopt the conventional method of Chinese medicine preparation to be prepared into any conventional oral preparations, as pill, powder, tablet, oral liquid etc.For example these crude drug grind into fine powder mix homogeneously can be made powder takes after mixing it with water; Can use decocting, get after filtration filtrate, add antiseptic to make oral liquid; Also can directly take decoction in case of necessity.
Medicine of the present invention has clearing away heat and cooling blood, and the effects such as YIN nourishing, tranquilizing by nourishing the heart of promoting the production of body fluid, and good effect have no side effect, and according to clinical 100 routine patients are observed statistics, uses 80%, two of one of the medicine of the present invention total effective rate course for the treatment of total effective rate course for the treatment of 95%.
The specific embodiment
Embodiment one, 55 parts of Radix Rehmanniae, 10 parts of Radix Asparagis, 10 parts of Radix Ophiopogonis, 25 parts of Semen Ziziphi Spinosaes, 7 parts of Semen Platycladi, 10 parts of Radix Scrophulariaes, 20 parts of Radix Salviae Miltiorrhizaes, 7 parts of Cortex Moutans, 5 parts of Fructus Gardeniaes, 4 parts of Radix Bupleuri, 7 parts of Radix Angelicae Sinensis, 20 parts of the Radix Paeoniae Albas, 10 parts, Poria, 5 parts of Radix Curcumaes, 25 parts of Caulis Polygoni Multiflori, 45 parts of Concha Margaritiferas, 45 parts of Dens Draconiss.
Embodiment two, 60 parts of Radix Rehmanniae, 15 parts of Radix Asparagis, 15 parts of Radix Ophiopogonis, 30 parts of Semen Ziziphi Spinosaes, 12 parts of Semen Platycladi, 15 parts of Radix Scrophulariaes, 24 parts of Radix Salviae Miltiorrhizaes, 12 parts of Cortex Moutans, 10 parts of Fructus Gardeniaes, 9 parts of Radix Bupleuri, 12 parts of Radix Angelicae Sinensis, 24 parts of the Radix Paeoniae Albas, 15 parts, Poria, 10 parts of Radix Curcumaes, 30 parts of Caulis Polygoni Multiflori, 50 parts of Concha Margaritiferas, 50 parts of Dens Draconiss.
Embodiment three, 65 parts of Radix Rehmanniae, 20 parts of Radix Asparagis, 20 parts of Radix Ophiopogonis, 35 parts of Semen Ziziphi Spinosaes, 17 parts of Semen Platycladi, 20 parts of Radix Scrophulariaes, 28 parts of Radix Salviae Miltiorrhizaes, 17 parts of Cortex Moutans, 15 parts of Fructus Gardeniaes, 14 parts of Radix Bupleuri, 17 parts of Radix Angelicae Sinensis, 28 parts of the Radix Paeoniae Albas, 20 parts, Poria, 15 parts of Radix Curcumaes, 35 parts of Caulis Polygoni Multiflori, 55 parts of Concha Margaritiferas, 55 parts of Dens Draconiss.
The below is the clinical statistics data that the patient uses medicine of the present invention:
One, physical data
Accept patient's totally 100 examples for medical treatment, male's 32 examples wherein, women's 68 examples, M-F 0.5:1,43 years old mean age.
Two, tcm diagnosis standard:
1, the lighter's difficulty of falling asleep or sleep but easy to wake are insomnia after waking up, and severe one is lain awake all night.
2, often with headache, giddy, cardiopalmus, forgetful, the diseases such as dreaminess.
3, no abnormal through each system and lab testing.
Three, Therapeutic Method
According to drug weight proportioning of the present invention, weighting raw materials (daily dose), decocting, filter and remove residue services once sooner or later, and 20 is a course for the treatment of.
Four, efficacy assessment standard
1, cure: easily fall asleep or sleep and recover normal, can sleep more than 7 hours every night, subjective symptoms disappears substantially;
2, produce effects: sleep obviously improves, and falls asleep easier, can sleep every night more than 5 hours, and the subjective symptoms SPR;
3, effective: still can fall asleep after treatment, sleep extends 2-3 hour, and subjective symptoms before alleviates, or slight recurrence is occasionally arranged;
4, invalid: after treatment, sleep state and subjective symptoms have no improvement.
Five, therapeutic outcome statistics
Wherein: total effective rate=cure rate+obvious effective rate+effective percentage
Model case and curative effect:
Case one, Zheng, female, 28 years old age, intractable insomnia 4 years, difficulty falling asleep often lies on a bed and all can not fall asleep in three or four hours, also often has horrible nightmares even fall asleep, often early awakening, again can't fall asleep after waking up, the second day panesthesia's fatigue and weak, vexed that gets up.The patient takes Chinese medicine of the present invention after course for the treatment of, and sleep obviously improves, and falls asleep easier, can sleep about 7 hours every night, and subjective symptoms disappears substantially, cures.
Case two, Chen, female, 33 years old age, teacher.Over nearly 7 years, often insomnia, sometimes all through the night, be difficult to fall asleep, dizzy aggravation, and spiritlessness and weakness, hypomnesis is often used the tranquilizer hypnosis.The patient takes Chinese medicine of the present invention after two courses for the treatment of, and sleep obviously improves, and falls asleep easier, can sleep every night more than 5 hours, and subjective symptoms SPR, produce effects.
Case three, Wu, the female, 54 years old age, be subjected to after direct stimulation insomnia more than ten years, long-term taking hypnosis Western medicine, and with dizziness, uncomfortable in chest, poor memory, extremity are tired, receive food generally, and light red tongue, yellow fur are slightly turbid, stringy and rolling pulse, every physico-chemical examination is without extremely.The patient takes Chinese medicine of the present invention after two courses for the treatment of, can fall asleep, and sleep extends about 5 hours, and subjective symptoms before alleviates, effectively.
Claims (2)
1. Chinese medicine composition that is used for intractable insomnia, it is characterized in that, this Chinese medicine composition is the ingredients by following weight portion: Radix Rehmanniae 55-65 part, Radix Asparagi 10-20 part, Radix Ophiopogonis 10-20 part, Semen Ziziphi Spinosae 25-35 part, Semen Platycladi 7-17 part, Radix Scrophulariae 10-20 part, Radix Salviae Miltiorrhizae 20-28 part, Cortex Moutan 7-17 part, Fructus Gardeniae 5-15 part, Radix Bupleuri 4-14 part, Radix Angelicae Sinensis 7-17 part, Radix Paeoniae Alba 20-28 part, Poria 10-20 part, Radix Curcumae 5-15 part, Caulis Polygoni Multiflori 25-35 part, Concha Margaritifera 45-55 part, Dens Draconis 45-55 part.
2. Chinese medicine composition for intractable insomnia described according to claims 1, it is characterized in that, by the ingredients of following weight portion: 60 parts of Radix Rehmanniae, 15 parts of Radix Asparagis, 15 parts of Radix Ophiopogonis, 30 parts of Semen Ziziphi Spinosaes, 12 parts of Semen Platycladi, 15 parts of Radix Scrophulariaes, 24 parts of Radix Salviae Miltiorrhizaes, 12 parts of Cortex Moutans, 10 parts of Fructus Gardeniaes, 9 parts of Radix Bupleuri, 12 parts of Radix Angelicae Sinensis, 24 parts of the Radix Paeoniae Albas, 15 parts, Poria, 10 parts of Radix Curcumaes, 30 parts of Caulis Polygoni Multiflori, 50 parts of Concha Margaritiferas, 50 parts of Dens Draconiss.
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| CN103877199A (en) * | 2013-12-10 | 2014-06-25 | 济南新起点医药科技有限公司 | Traditional Chinese medicine composition for treating insomnia caused by fire excess from yin deficiency |
| CN105233207A (en) * | 2015-10-19 | 2016-01-13 | 南阳医学高等专科学校 | Traditional Chinese medicinal composition for relieving pressure, soothing heart, invigorating brain and enhancing intelligence |
| CN105878886A (en) * | 2014-12-17 | 2016-08-24 | 杨少梅 | Medicine for treating sleep disorder |
| CN105999113A (en) * | 2016-07-22 | 2016-10-12 | 刘德喜 | Traditional Chinese medicine composition for treating intractable insomnia and preparation method thereof |
| CN106421310A (en) * | 2016-07-01 | 2017-02-22 | 覃益祥 | Brain-strengthening and eyesight-improving traditional Chinese medicine |
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| CN105233207B (en) * | 2015-10-19 | 2020-10-13 | 南阳医学高等专科学校 | Traditional Chinese medicine composition for relieving pressure, soothing heart, strengthening brain and improving intelligence |
| CN106421310A (en) * | 2016-07-01 | 2017-02-22 | 覃益祥 | Brain-strengthening and eyesight-improving traditional Chinese medicine |
| CN105999113A (en) * | 2016-07-22 | 2016-10-12 | 刘德喜 | Traditional Chinese medicine composition for treating intractable insomnia and preparation method thereof |
| CN105999113B (en) * | 2016-07-22 | 2019-10-29 | 刘德喜 | A kind of Chinese medicine composition and preparation method thereof for treating intractable aypnia |
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