CN101274044A - Medicament for preventing and treating fatty liver and method of preparing the same - Google Patents
Medicament for preventing and treating fatty liver and method of preparing the same Download PDFInfo
- Publication number
- CN101274044A CN101274044A CNA2008101117197A CN200810111719A CN101274044A CN 101274044 A CN101274044 A CN 101274044A CN A2008101117197 A CNA2008101117197 A CN A2008101117197A CN 200810111719 A CN200810111719 A CN 200810111719A CN 101274044 A CN101274044 A CN 101274044A
- Authority
- CN
- China
- Prior art keywords
- weight portion
- radix
- weight portions
- weight
- medicine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a medicine applied to preventing and treating fatty liver and a preparation method thereof. The invention is made from gynostemma pentaphyllum makino, ilexlutifolia thumb, sanchi, root of thomson kudzuvine, hawkthorn fruit, root of red rooted salvia, rhizoma alismatis, lotus leaf and other traditional Chinese medicine, has the functions of discharging liver, regulating qi, strengthening spleen and stomach, activating blood, dissolving stasis, eliminating phlegm and softening hard mass, is applied to preventing and treating the fatty liver and has actual effect.
Description
Technical field
The present invention relates to a kind of medicine and preparation method thereof, particularly relate to a kind of medicine of fatty liver and preparation method thereof that is used to prevent and treat, belong to the novel technique field.
Background technology
Fatty liver is the excessive a kind of clinical picture piled up of the interior fat of hepatocyte that multiple paathogenic factor causes, cause that as reasons such as nutritional disorder, diabetes, hepatitis, medicines liver reduces the picked-up of fat, synthetic increase or transhipment, utilization, the bulk deposition that all can cause fat in the hepatocyte, and form fatty liver.
Fatty liver can cause liver function damage, even can cause hepatic fibrosis, finally develops into liver cirrhosis.
In recent years, along with the continuous change of people's dietary habit and life style, the sickness rate of fatty liver also presents continuous growth trend, and young and middle-aged people's sickness rate growth rate is very fast.
The morbidity of fatty liver is a concealment process that slowly, increases the weight of gradually, and the patient does not have any clinical malaise symptoms usually.Clinically fatty liver still there are not satisfied Therapeutic Method and medicine at present.The obvious rising of pathogenesis of fatty liver rate and the deficiency of Therapeutic Method have formed great contrast, and at present, fatty liver has become a big hidden danger that threatens human health.
Summary of the invention
One of the object of the invention is to provide a kind of medicine that is used to prevent and treat fatty liver, and this product has liver-smoothing, qi-regulating, invigorating the spleen and regulating the stomach, blood circulation promoting and blood stasis dispelling, the effect of the softening the hard mass that eliminates the phlegm.
Two of the object of the invention is to provide the preparation method of this medicine.
Fatty liver belongs to categories such as Chinese medicine " feeling of fullness ", " costalgia ", " fullness and oppression sensation in the epigastrium due to accumulation of phlegm ", " gathering ".The cause of disease is long-term greasy and surfeit flavour, being addicted to drink forms, and diseased region is at liver, spleen, stagnation of liver-QI with deficiency of the spleen, and the fortuneization mistake is strong, poly-ly wets into expectorant, stagnation of QI due to depression of the liver, hematogenous blockage, phlegm and blood stasis is stopped up the resistance meridians, gathers the side of body down, with the passing of time causes a disease.
The present invention is on the modern clinical research experiential basis, in conjunction with China's traditional Chinese medicine theory and treatment experience, control experience by a large amount of clinical practice research and dialectical opinion, the pure Chinese medicine with effects such as function of spleen and stomach regulating, 'Shugan Lidan ', blood circulation promoting and blood stasis dispelling of science compatibility, be used for prevention and treatment fatty liver definite effect, and without any side effects, be suitable for taking for a long time.
The present invention adopts modern preparation technique, by extract, concentrate, processes such as drying makes acceptable drug preparation clinically, is suitable for wide clinical application, it is simple to have production technology, characteristics such as taking convenience can be developed as medicine or health food.
The medicine that is used to prevent and treat fatty liver provided by the invention is to be made by following raw materials by weight proportions:
Herb Gynostemmae Pentaphylli 10～40 weight portion Folium Ilicis 5～20 weight portions
Radix Notoginseng 5～20 weight portion Radix Puerariaes 10～30 weight portions
Fructus Crataegi 5～20 weight portion Radix Salviae Miltiorrhizaes 10～30 weight portions
Rhizoma Alismatis 5～20 weight portion Folium Nelumbinis 5～20 weight portions
Rhizoma Coptidis 5～20 weight portion Herba Artemisiae Scopariaes 5～20 weight portions
Semen Cassiae 5～20 weight portion Radix Codonopsis 10～30 weight portions
The Radix Paeoniae Alba 5～20 weight portion Fructus Gardeniaes 5～20 weight portions
Further, the medicine that is used to prevent and treat fatty liver provided by the invention can be adopted as following raw materials by weight proportions especially and make:
Herb Gynostemmae Pentaphylli 20 weight portion Folium Ilicis 10 weight portions
Radix Notoginseng 10 weight portion Radix Puerariaes 15 weight portions
Fructus Crataegi 15 weight portion Radix Salviae Miltiorrhizaes 10 weight portions
Rhizoma Alismatis 10 weight portion Folium Nelumbinis 15 weight portions
Rhizoma Coptidis 10 weight portion Herba Artemisiae Scopariaes 10 weight portions
Semen Cassiae 10 weight portion Radix Codonopsis 10 weight portions
The Radix Paeoniae Alba 10 weight portion Fructus Gardeniaes 10 weight portions
Provided by the inventionly be used to prevent and to treat the preparation method of medicine of fatty liver as follows:
(1) get Radix Notoginseng, be ground into coarse powder, with 6～10 times of amount alcohol reflux of 50%～95% 2～4 times, each 1～4 hour, extract pure liquid and filter, merging filtrate, decompression recycling ethanol and to be concentrated into relative density be 1.10～1.30 clear paste, standby;
(2) get Radix Puerariae, Radix Salviae Miltiorrhizae, be ground into coarse powder, with 6～12 times of amount alcohol reflux of 50%～95% 2～3 times, each 1～3 hour, extract pure liquid and filter, merging filtrate, decompression recycling ethanol and to be concentrated into relative density be 1.10～1.30 clear paste, standby;
(3) get Herb Gynostemmae Pentaphylli, Folium Ilicis, Fructus Crataegi, Rhizoma Alismatis, Folium Nelumbinis, Rhizoma Coptidis, Herba Artemisiae Scopariae, Semen Cassiae, Radix Codonopsis, the Radix Paeoniae Alba, Fructus Gardeniae, be ground into coarse powder, decoct 2～3 times with 8～12 times of water gagings, each 1～2 hour, decocting liquid filters, merging filtrate is concentrated into relative density and is 1.10～1.30 clear paste, and is standby;
(4) get above-mentioned clear paste, mix homogeneously adopts the conventional formulation method, adds the suitable formulations adjuvant, molding, and packing, check, promptly.
The specific embodiment
Embodiment 1
Prescription is formed:
Herb Gynostemmae Pentaphylli 100g Folium Ilicis 50g Radix Notoginseng 50g Radix Puerariae 75g
Fructus Crataegi 75g Radix Salviae Miltiorrhizae 50g Rhizoma Alismatis 50g Folium Nelumbinis 75g
Rhizoma Coptidis 50g Herba Artemisiae Scopariae 50g Semen Cassiae 50g Radix Codonopsis 50g
Radix Paeoniae Alba 50g Fructus Gardeniae 50g
Make 1000 altogether
Preparation method:
(1) gets Radix Notoginseng, be ground into coarse powder,, extract pure liquid and filter with 10 times of amount alcohol reflux of 70% 4 hours; Medicinal residues add 10 times of amount alcohol reflux of 70% 2 hours, extract pure liquid and filter; Medicinal residues add 10 times of amount alcohol reflux of 70% 2 hours again, extract pure liquid and filter; Merging filtrate, decompression recycling ethanol and to be concentrated into relative density be 1.15 clear paste, standby;
(2) get Radix Puerariae, Radix Salviae Miltiorrhizae, be ground into coarse powder,, extract pure liquid and filter with 10 times of amount alcohol reflux of 85% 2 hours; Medicinal residues add 10 times of amount alcohol reflux of 85% 2 hours, extract pure liquid and filter; Medicinal residues add 8 times of amount alcohol reflux of 85% 1 hour again, extract pure liquid and filter; Merging filtrate, decompression recycling ethanol and to be concentrated into relative density be 1.15 clear paste, standby;
(3) get Herb Gynostemmae Pentaphylli, Folium Ilicis, Fructus Crataegi, Rhizoma Alismatis, Folium Nelumbinis, Rhizoma Coptidis, Herba Artemisiae Scopariae, Semen Cassiae, Radix Codonopsis, the Radix Paeoniae Alba, Fructus Gardeniae, be ground into coarse powder, decocted 2 hours with 12 times of water gagings, decocting liquid filters; Medicinal residues add 10 times of water gagings and decocted 1.5 hours, and decocting liquid filters; Medicinal residues add 10 times of water gagings again and decocted 1 hour, and decocting liquid filters; Merging filtrate is concentrated into relative density and is 1.15 clear paste, and is standby;
(4) get above-mentioned clear paste, mix homogeneously adds starch, and mixing is made granule, drying, and granulate adds 0.4% magnesium stearate, mix homogeneously, tabletting, coating, packing, check, promptly.
Embodiment 2
Prescription is formed:
Herb Gynostemmae Pentaphylli 160g Folium Ilicis 80g Radix Notoginseng 80g Radix Puerariae 120g
Fructus Crataegi 120g Radix Salviae Miltiorrhizae 80g Rhizoma Alismatis 80g Folium Nelumbinis 120g
Rhizoma Coptidis 80g Herba Artemisiae Scopariae 80g Semen Cassiae 80g Radix Codonopsis 80g
Radix Paeoniae Alba 80g Fructus Gardeniae 80g
Dextrin 50g
Make 1000 altogether
Preparation method:
(1) gets Radix Notoginseng, be ground into coarse powder,, extract pure liquid and filter with 8 times of amount alcohol reflux of 75% 2 hours; Medicinal residues add 8 times of amount alcohol reflux of 75% 2 hours, extract pure liquid and filter; Medicinal residues add 8 times of amount alcohol reflux of 75% 2 hours again, extract pure liquid and filter; Medicinal residues add 8 times of amount alcohol reflux of 75% 2 hours again, extract pure liquid and filter; Merging filtrate, decompression recycling ethanol and to be concentrated into relative density be 1.30 clear paste, standby;
(2) get Radix Puerariae, Radix Salviae Miltiorrhizae, be ground into coarse powder,, extract pure liquid and filter with 10 times of amount alcohol reflux of 75% 2 hours; Medicinal residues add 8 times of amount alcohol reflux of 75% 2 hours, extract pure liquid and filter; Medicinal residues add 8 times of amount alcohol reflux of 75% 1 hour again, extract pure liquid and filter; Merging filtrate, decompression recycling ethanol and to be concentrated into relative density be 1.30 clear paste, standby;
(3) get Herb Gynostemmae Pentaphylli, Folium Ilicis, Fructus Crataegi, Rhizoma Alismatis, Folium Nelumbinis, Rhizoma Coptidis, Herba Artemisiae Scopariae, Semen Cassiae, Radix Codonopsis, the Radix Paeoniae Alba, Fructus Gardeniae, be ground into coarse powder, decocted 2 hours with 12 times of water gagings, decocting liquid filters; Medicinal residues add 10 times of water gagings and decocted 1.5 hours, and decocting liquid filters; Medicinal residues add 10 times of water gagings again and decocted 1 hour, and decocting liquid filters; Merging filtrate is concentrated into relative density and is 1.30 clear paste, and is standby;
(4) get above-mentioned clear paste, mix homogeneously adds dextrin, and drying is ground into fine powder, crosses 100 mesh sieves, gets dry extract, and sealing is preserved, and is standby;
(5) get dry extract, add 0.6% magnesium stearate, mixing, encapsulated, packing, check, promptly.
Claims (3)
1, be used to prevent and treat the medicine of fatty liver, it is characterized in that this medicine is to be made by following raw materials by weight proportions:
Herb Gynostemmae Pentaphylli 10～40 weight portion Folium Ilicis 5～20 weight portions
Radix Notoginseng 5～20 weight portion Radix Puerariaes 10～30 weight portions
Fructus Crataegi 5～20 weight portion Radix Salviae Miltiorrhizaes 10～30 weight portions
Rhizoma Alismatis 5～20 weight portion Folium Nelumbinis 5～20 weight portions
Rhizoma Coptidis 5～20 weight portion Herba Artemisiae Scopariaes 5～20 weight portions
Semen Cassiae 5～20 weight portion Radix Codonopsis 10～30 weight portions
The Radix Paeoniae Alba 5～20 weight portion Fructus Gardeniaes 5～20 weight portions
2, the medicine that is used to prevent and treat fatty liver as claimed in claim 1 is characterized in that this medicine is to be made by following raw materials by weight proportions:
Herb Gynostemmae Pentaphylli 20 weight portion Folium Ilicis 10 weight portions
Radix Notoginseng 10 weight portion Radix Puerariaes 15 weight portions
Fructus Crataegi 15 weight portion Radix Salviae Miltiorrhizaes 10 weight portions
Rhizoma Alismatis 10 weight portion Folium Nelumbinis 15 weight portions
Rhizoma Coptidis 10 weight portion Herba Artemisiae Scopariaes 10 weight portions
Semen Cassiae 10 weight portion Radix Codonopsis 10 weight portions
The Radix Paeoniae Alba 10 weight portion Fructus Gardeniaes 10 weight portions
3, as claimed in claim 1 or 2ly be used to prevent and to treat the preparation method of medicine of fatty liver as follows:
(1) get Radix Notoginseng, be ground into coarse powder, with 6～10 times of amount alcohol reflux of 50%～95% 2～4 times, each 1～4 hour, extract pure liquid and filter, merging filtrate, decompression recycling ethanol and to be concentrated into relative density be 1.10～1.30 clear paste, standby;
(2) get Radix Puerariae, Radix Salviae Miltiorrhizae, be ground into coarse powder, with 6～12 times of amount alcohol reflux of 50%～95% 2～3 times, each 1～3 hour, extract pure liquid and filter, merging filtrate, decompression recycling ethanol and to be concentrated into relative density be 1.10～1.30 clear paste, standby;
(3) get Herb Gynostemmae Pentaphylli, Folium Ilicis, Fructus Crataegi, Rhizoma Alismatis, Folium Nelumbinis, Rhizoma Coptidis, Herba Artemisiae Scopariae, Semen Cassiae, Radix Codonopsis, the Radix Paeoniae Alba, Fructus Gardeniae, be ground into coarse powder, decoct 2～3 times with 8～12 times of water gagings, each 1～2 hour, decocting liquid filters, merging filtrate is concentrated into relative density and is 1.10～1.30 clear paste, and is standby;
(4) get above-mentioned clear paste, mix homogeneously adopts the conventional formulation method, adds the suitable formulations adjuvant, molding, and packing, check, promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008101117197A CN101274044A (en) | 2008-05-15 | 2008-05-15 | Medicament for preventing and treating fatty liver and method of preparing the same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008101117197A CN101274044A (en) | 2008-05-15 | 2008-05-15 | Medicament for preventing and treating fatty liver and method of preparing the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101274044A true CN101274044A (en) | 2008-10-01 |
Family
ID=39994180
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2008101117197A Pending CN101274044A (en) | 2008-05-15 | 2008-05-15 | Medicament for preventing and treating fatty liver and method of preparing the same |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101274044A (en) |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102293969A (en) * | 2011-09-09 | 2011-12-28 | 张�林 | Chinese medicine for treating fatty liver |
| CN101766737B (en) * | 2008-12-29 | 2012-04-18 | 北京施强时代医药技术开发有限公司 | Liver-soothing lipid-lowing drug composition and preparation method thereof |
| CN102641469A (en) * | 2011-02-22 | 2012-08-22 | 北京中医药大学东方医院 | Medicinal composition for preventing or treating nonalcoholic steatohepatitis |
| CN102846879A (en) * | 2012-09-29 | 2013-01-02 | 广西梧州制药（集团）股份有限公司 | Composition for depressing blood fat |
| CN103055057A (en) * | 2012-08-31 | 2013-04-24 | 中国科学院生物物理研究所 | Plant weight-losing and fat-reducing composite compatible to L-carnitine |
| CN103705854A (en) * | 2013-12-30 | 2014-04-09 | 郭兰春 | Semen cassiae, fructus lycii and glossy privet fruit oral solution with functions of tonifying liver and reducing fat |
| CN105168434A (en) * | 2015-08-14 | 2015-12-23 | 湖北坤艳药业有限责任公司 | Health care product reducing blood fat auxiliarily and preparation method therefor |
| CN105166887A (en) * | 2015-08-14 | 2015-12-23 | 湖北坤艳药业有限责任公司 | Health care product auxiliary material and applications |
| CN105456575A (en) * | 2015-12-31 | 2016-04-06 | 广州中医药大学 | Traditional Chinese medicine preparation for treating fatty liver |
| CN109568563A (en) * | 2019-02-02 | 2019-04-05 | 北京胜泰生物医药科技有限公司 | A kind of composition and preparation method thereof of zeolite-loaded natural extract |
| CN111110735A (en) * | 2020-02-28 | 2020-05-08 | 贵州中医药大学 | Lipid-lowering pharmaceutical composition, preparation method and application |
-
2008
- 2008-05-15 CN CNA2008101117197A patent/CN101274044A/en active Pending
Cited By (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101766737B (en) * | 2008-12-29 | 2012-04-18 | 北京施强时代医药技术开发有限公司 | Liver-soothing lipid-lowing drug composition and preparation method thereof |
| CN102641469B (en) * | 2011-02-22 | 2014-07-02 | 北京中医药大学东方医院 | Medicinal composition for preventing or treating nonalcoholic steatohepatitis |
| CN102641469A (en) * | 2011-02-22 | 2012-08-22 | 北京中医药大学东方医院 | Medicinal composition for preventing or treating nonalcoholic steatohepatitis |
| CN102293969B (en) * | 2011-09-09 | 2012-11-28 | 刘春青 | Chinese medicine for treating fatty liver |
| CN102293969A (en) * | 2011-09-09 | 2011-12-28 | 张�林 | Chinese medicine for treating fatty liver |
| CN103055057A (en) * | 2012-08-31 | 2013-04-24 | 中国科学院生物物理研究所 | Plant weight-losing and fat-reducing composite compatible to L-carnitine |
| CN103055057B (en) * | 2012-08-31 | 2015-04-15 | 中国科学院生物物理研究所 | Plant weight-losing and fat-reducing composite compatible to L-carnitine |
| CN102846879A (en) * | 2012-09-29 | 2013-01-02 | 广西梧州制药（集团）股份有限公司 | Composition for depressing blood fat |
| CN103705854A (en) * | 2013-12-30 | 2014-04-09 | 郭兰春 | Semen cassiae, fructus lycii and glossy privet fruit oral solution with functions of tonifying liver and reducing fat |
| CN105168434A (en) * | 2015-08-14 | 2015-12-23 | 湖北坤艳药业有限责任公司 | Health care product reducing blood fat auxiliarily and preparation method therefor |
| CN105166887A (en) * | 2015-08-14 | 2015-12-23 | 湖北坤艳药业有限责任公司 | Health care product auxiliary material and applications |
| CN105168434B (en) * | 2015-08-14 | 2019-04-02 | 湖北坤艳药业有限责任公司 | A kind of health care product and preparation method thereof of complementary reducing blood lipid |
| CN105456575A (en) * | 2015-12-31 | 2016-04-06 | 广州中医药大学 | Traditional Chinese medicine preparation for treating fatty liver |
| CN109568563A (en) * | 2019-02-02 | 2019-04-05 | 北京胜泰生物医药科技有限公司 | A kind of composition and preparation method thereof of zeolite-loaded natural extract |
| CN109568563B (en) * | 2019-02-02 | 2023-01-17 | 北京胜泰生物医药科技有限公司 | Zeolite-loaded natural extract composition and preparation method thereof |
| CN111110735A (en) * | 2020-02-28 | 2020-05-08 | 贵州中医药大学 | Lipid-lowering pharmaceutical composition, preparation method and application |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101274044A (en) | Medicament for preventing and treating fatty liver and method of preparing the same | |
| CN102335379A (en) | Traditional Chinese preparation for relieving alcoholism and protecting livers | |
| CN103372169A (en) | Preparation for treating alcoholism and dispelling effects of alcohol | |
| CN1723926A (en) | Traditional Chinese medicine liquor and preparation method thereof | |
| CN104083727A (en) | Traditional Chinese medicine composition for nourishing and protecting liver | |
| CN1891279A (en) | Capsule for treating cardio-cerebrovasular disease | |
| CN102091177A (en) | Traditional Chinese medicine health product for adjuvant therapy of diabetes | |
| CN102210719A (en) | Manufacturing method of Chinese medical brick | |
| CN106692780B (en) | Composition for preventing and relieving diabetes and complications thereof | |
| CN102430049A (en) | Liver-nourishing kidney-tonifying tea and preparation method thereof | |
| CN101744969B (en) | Medicinal composition for treating insomnia and preparation method thereof | |
| CN106492138A (en) | The Chinese medicine preparation for the treatment of insomnia | |
| CN104958536A (en) | Chinese medicinal composition for treating diabetes and preparation method thereof | |
| CN1305816A (en) | Medicine for treating diabetes | |
| CN105031106A (en) | Lavipeditum powder for relieving fatigue and preparation method thereof | |
| CN101757206A (en) | Chinese medicine preparation for treating chronic colitis | |
| CN101336998B (en) | Traditional Chinese medicine for treating whelk | |
| CN101167921A (en) | Medicinal composition for treating stomachache and preparation process thereof | |
| CN102813733A (en) | Herb tea capable of resisting cancer, preventing diabetes mellitus and enhancing immunity | |
| CN103405574B (en) | Medicinal composition for treating hypertension | |
| CN106109968A (en) | Rhizoma Gastrodiae, Radix Polygoni Multiflori Preparata pharmaceutical composition and preparation method thereof | |
| CN102784353B (en) | Medicament for treating hepatic cirrhosis ascites | |
| CN101664513A (en) | Chinese herbal medicinal composition for treating hyperlipidaemia | |
| CN1907406A (en) | Decoction preparation for treating asomnia of protracted disease intruding into collateral and its preparation process | |
| CN103948875A (en) | Medicine for treating hepatitis B and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Open date: 20081001 |