CN100563634C - A kind of Herba Sidae Rhombifoliae soup drop pill - Google Patents

Abstract

The invention provides a kind of alternate attack of chill and fever that is used for the treatment of, feeling of fullness and disecomfort in the chest and hypochondrium, vexed happiness is told, the medicine of bitter taste in the mouth and dry throat, the present invention overcome present drop pill adjuvant pure natural degree not high and at present the common chemical synthesis auxiliary material not in some national food additive catalogue, the relatively poor shortcoming of drop pill mouthfeel, be that a kind of natural degree is higher, the pharmaceutical preparation that safety is stronger, toxic and side effects is lower.

Description

A kind of Xiaobupleurum soup dripping pill

technical field

The invention relates to a traditional Chinese medicine preparation and a preparation method thereof. Specifically, the invention relates to a Xiaochaihutang dripping pill, and the invention also discloses a preparation method thereof.

Background technique

Xiao Chaihu Decoction comes from Zhang Zhongjing's "Treatise on Febrile Diseases", consisting of Bupleurum, Scutellaria, Ginseng, Pinellia, Licorice, Ginger, and Jujube. The original book is used to treat typhoid shaoyang syndrome and the symptoms caused by it: as well as jaundice and other shaoyang syndromes. In long-term medical practice, this prescription is widely used in the treatment of liver and gallbladder, digestion, endocrine, blood, immune and other system diseases .

As a common synthetic chemical substance commonly used in modern medicine, it has pervaded every corner of human life. Chemical synthetic drugs have become the mainstream of medicine. Reality and the latest scientific research results have questioned this situation, especially with the continuous emergence of toxic and side effects of chemicals, changes in the spectrum of diseases and changes in medical models, modern medicine has been challenged unprecedentedly, and people are also Gradually pin their hopes on the application and development of traditional medicine. The trend of advocating returning to nature, emphasizing the use of herbal medicines, being keen on traditional therapies, and advocating natural medicines is taking shape. Making full use of natural substances is the best choice for human beings.

At present, natural medicines have a certain market in the world. With the increase of people's awareness of health requirements and the aging of the population, sub-health status, people are more eager to return to nature and use pure natural medicines to treat 1. Prevent some problems that cannot be solved by chemically synthesized drugs, so the application of natural herbal medicines has expanded beyond the background of its original national traditional culture. It has become the goal pursued by pharmaceutical companies all over the world to seek medicines with low side effects and high quality and low price from natural medicines. The European Community has carried out unified legislation on herbal medicines, and the status of herbal medicines in countries such as Canada and Australia has been legalized. The US government has also drafted a management method for herbal medicines, and began to accept compound mixtures of natural medicines as therapeutic medicines. These are traditional Chinese medicines as therapeutic medicines. Entering the international pharmaceutical market provides a good international environment. On the other hand, with the acceleration of the global economic integration process, especially my country's formal accession to the WTO, the breadth and depth of the Chinese pharmaceutical market's integration into the international pharmaceutical market will be further intensified. Faced with fierce competition from powerful multinational pharmaceutical groups and the huge impact of traditional medicine products from Asian countries such as Japan, South Korea, India, and Thailand, and herbal medicines from European countries such as Germany and France, many products produced by traditional Chinese medicine in my country cannot meet the requirements of the international pharmaceutical market. rejected by standards and requirements.

With the global expansion of the market and the requirement of human beings to return to nature, the use of drugs with low toxicity and side effects, especially pure natural drugs, has become the first choice of people. The dropping pill preparation is a new type of Chinese medicine preparation with high efficiency and quick effect. The shortcomings and deficiencies of traditional Chinese medicine preparations in the past, but the current drop pill preparations generally face the following problems: 1. The drop pill auxiliary materials are not purely natural: at present, most of the drop pill base auxiliary materials are chemically synthesized, and the natural degree is low. New alternatives The search for matrix excipients, especially the search for alternative matrix excipients with a high degree of naturalness and the determination of their preparation process, is also very difficult, because the preparation conditions required for common and possible substitutes for natural matrix excipients are very harsh. And its dripping pill dripping conditions are all the key factors that affect the preparation and molding of dripping pills. If the melting temperature of the excipient is too high, the viscosity will be low and the plasticity will be poor. If the melting temperature of the excipient is too low, although the plasticity is strong, the dropping pills have disadvantages such as easy sticking and deformation. The accessories are very hard work. 2. Problems encountered in the export of dripping pills: With the development of the economy, the market is becoming more and more internationalized, and China is also trying to adapt to this trend. Currently, Chinese medicine dripping pills, which are used as health food, have been successfully exported to many countries, but There are also many problems at present, because different countries have different approvals for the excipients selected for the preparation of Chinese medicine dripping pills, especially in Europe with developed industries, which have stricter regulations on food excipients and pharmaceutical excipients, and the drops exported as health food The chemically synthesized auxiliary materials (such as polyethylene glycol) selected for pill preparations are not listed in the food additive catalogs of some countries, which is very unfavorable for Chinese medicine dripping pill preparations to enter the international market, and has become a stumbling block for Chinese medicine to enter the international market. Therefore, looking for One or more new matrix excipients that can be accepted by the international market are particularly important and urgent. 3. Disadvantages of mouthfeel and speed of onset of action: Poor taste of traditional Chinese medicine and its preparations is one of its major characteristics. When people take certain medicines, they are far more afraid of the bad taste of the medicine than they are of the disease. What's more, some patients give up the treatment of traditional Chinese medicine because they can't overcome the bad taste or smell of traditional Chinese medicine or its preparations. For example, making the medicine into capsules or sugar-coated tablets can improve the taste and reduce stimulation, but the disintegration speed is prolonged. , It is not conducive to the rapid onset of effect of the drug, and it is not suitable for some diseases, especially the diseases that require the rapid onset of the drug. 4. Difficult preparation process for industrial production of dripping pills: In the replacement process of dripping pill preparation auxiliary materials, it is very difficult to determine the preparation process for industrial production, such as the melting temperature of matrix auxiliary materials, dripping temperature, auxiliary materials and The ratio of the medicine, the ratio of the caliber of the dropper, and the condensing agent are all factors that affect the dropping pills. Therefore, it is a time-consuming and expensive work to replace the matrix and be suitable for industrial production.

In order to change the long-term situation that the base excipients of drop pills are mainly chemically synthesized excipients, and solve the problem that the base of drop pills is currently facing a low level of naturalness, it is increasingly unable to meet people's requirements for returning to nature, taking pure natural medicines with low toxicity and no side effects It can also solve some problems encountered in the export process of Chinese medicine preparations, especially dripping pill preparations, and enhance the competitiveness of the international market; the present invention has invented a toxic and side effect through a large number of experiments and research on preparation technology. It is a pure Chinese medicine dripping pill preparation with low cost, significant curative effect, moderate price and suitable for industrialized large-scale production.

Contents of the invention

The object of the present invention is to provide a kind of Xiao Bupleuri dripping pill prepared with novel natural matrix auxiliary material.

Another object of the present invention is to provide a preparation method of Xiaobupleurum drop pill pharmaceutical preparation.

The matrix auxiliary material selected in the present invention is obtained through a large number of tests, has a small molecular weight, is easily soluble in water, has a faster dissolution rate, is highly natural, has lower toxic and side effects, and can reduce the irritating smell of the drug, and the oral cavity When taken orally, it has the characteristics of improving oral pH and oral odor. The base auxiliary material used in the present invention is a food flavoring agent, which has the characteristics of good taste and easy acceptance by patients. It is the development direction of the base auxiliary material in the future.

The selection of the pharmaceutical components, dosage and auxiliary materials of the present invention is also obtained through a large amount of exploration by the inventor, and the dosage of each component has good curative effect in the following ranges: Bupleurum 1-5%, Pinellia 15-5%. 20%, Scutellaria baicalensis 15-20%, Codonopsis 15-20%, Jujube 15-20%, Licorice 10-15%, Ginger 8-13%. : 1～1: 1, wherein auxiliary material comprises filler and plasticizing matrix, and said filler is selected from the natural auxiliary material of following one or more plant sources: erythritol, sorbitol, fructose, D- Ribo-γ-lactone, arabinol, trehalose, D-ribose, low-melting agarose, shellac, xylitol, raffinose, glucose, malic acid, citric acid, isomalt, lactitol, Maltose, etc., and their crystalline water compounds; said plasticizing matrix is selected from one or more of the following natural excipients derived from plants: starch and its derivatives, cellulose and its derivatives, gum arabic, dextran, Chitin, Tianqing Gum, Carrageenan, Indian Gum, Alginate Gum, Tragacanth Gum, Carrageenan Gum, Tamarind Gum, Pectin, Xanthan Gum, Alginic Acid and Its Salts, Dextrin, Cyclodextrin , agar, lactose; the starch and its derivatives such as pregelatinized starch, modified starch, hydroxypropyl starch, carboxymethyl starch, the cellulose and its derivatives such as methyl cellulose, microcrystalline cellulose, Sodium carboxymethyl cellulose, hydroxypropyl methyl cellulose, croscarmellose sodium, hydroxyethyl methyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose; preferred pharmaceutical group of the present invention The dosage and the choice of auxiliary materials are Bupleurum 3.7%, Pinellia 18.5%, Scutellaria baicalensis 18.5%, Codonopsis 18.5%, Jujube 18.5%, Glycyrrhiza 12.3%, Ginger 10%. The weight ratio to the auxiliary materials is 0.1:1～0.6:1, wherein the filler auxiliary materials are selected from one or more of the following plant-derived natural auxiliary materials: sorbitol, xylitol, lactitol, maltose, and their containing Crystalline hydrate; wherein the plasticizing matrix is selected from one or more of the following natural excipients of plant origin: pregelatinized starch, carboxymethyl starch, methylcellulose, sodium carboxymethylcellulose, hydroxypropyl Methyl cellulose, gum arabic, alginic acid, dextrin, cyclodextrin, agar, lactose; the selection of the best pharmaceutical component consumption and auxiliary materials of the present invention is that the weight ratio of the drug extract obtained by extraction and auxiliary materials is 0.2～1:0.4:1, wherein the filler auxiliary material is selected from one or more of the following plant-derived natural auxiliary materials: xylitol, lactitol; wherein the plasticizing matrix is selected from the following one or one The above plant-derived natural excipients: starch, gum arabic.

The above-mentioned dressings may also contain chemically synthesized auxiliary materials and animal-derived auxiliary materials, wherein fillers include phenyl glycol, cetyl alcohol, stearyl alcohol, sodium stearate, glyceryl stearate, glyceryl palmitate, urea, Polyoxyethylene monostearate, polyoxyethylene alkyl ether; wherein the plasticizing matrix includes polyvinylpyrrolidone, cross-linked polyvinylpyrrolidone, carbomer, polyvinyl alcohol, acrylic resin, poloxamer, and gelatin.

In the screening of the above excipients, we found: plant colloids such as carrageenan, tragacanth gum, pectin, agar, gum arabic, Indian gum, tamarind gum, locust bean gum, bletilla gum, guar gum, konjac Plant colloids such as gum and karaya gum have the characteristics of high viscosity, poor fluidity, and no solidification after condensation, while gum arabic has the properties of high concentration and low viscosity, and can be formulated into a 50% aqueous solution and still have fluidity. One of the characteristics that hydrophilic colloids do not have, gum arabic can drip out at high temperature and low concentration, but does not condense, and it is not easy to drip out at low temperature and high concentration, but can condense. Polysaccharides such as starch and its derivatives (such as gelatinized starch, carboxymethyl starch, etc.), cellulose derivatives (such as methyl cellulose, sodium carboxymethyl cellulose, hydroxypropyl methyl cellulose, etc.), alginic acid , dextrin, cyclodextrin, lactose and other polysaccharides. During the screening, it was found that alginic acid has a high viscosity and is jelly-like; Therefore, starch and its derivatives are preferred among polysaccharides. Polyols such as sorbitol (88-102°C), xylitol (88-94.5°C), lactitol (70-80°C), mannitol (166-169°C), maltitol (135-140°C), Polyhydric alcohols such as isomalt (98～103 ℃) are screened, and it is found that it has the following characteristics as the base of dropping pills: sorbitol, lactitol, and isomalt have poor fluidity; mannitol and maltitol have too high melting points; xylitol The coagulation is slightly poor. After preliminary screening, xylitol, lactitol, sorbitol are preferred in the selection of polyols, and xylitol is the best. Xylitol as a drop pill matrix has the following characteristics: at 91°C, xylitol is in a molten state, but it is not completely melted. Rapidly cooling down, it precipitates crystals quickly, and xylitol and extract flow after mixing in a certain proportion. Good resistance, can be dripped and condensed, but condensed into powder, loose structure, poor toughness, crushed when pinched. Organic acids and salts, bases such as citric acid (100°C), sorbic acid (133°C), succinic acid (181-189°C), sodium acetate (58°C) and other organic acids, salts, and bases, which are used as the base of dropping pills It has disadvantages such as too high melting point and inability to mix with traditional Chinese medicine extract.

Due to the shortcomings of the above single excipients in the preparation process of dripping pills, especially after we passed the above preliminary screening, we determined to screen the two kinds of excipients for combined use: mainly to carry out combined screening of the above various excipients, and finally determine the following Species: Plant colloid and plant colloid combination, polyol and polyol combination, polyol and plant colloid combination, xylitol and acacia gum combination, lactitol and acacia gum combination, xylitol-based compound Accessories. It is found that the preferred combination is the compound use of xylitol, lactitol and other auxiliary materials. This combination has the following characteristics: combination with mannitol: dripping, non-condensing; combination with sorbic acid: the two are immiscible; combination with lactitol: Can drip and condense, but is fragile; combined with pomelo peel pectin, tragacanth gum, and sodium alginate: high viscosity, unable to drip; combined with gum arabic: capable of dripping, slightly poor coagulation; combined with dextrin: able Drip and coagulation are slightly poor; combination with starch: dripping and coagulation are also better. Finally, it was determined that the best combination was the combination of xylitol and starch, lactitol and starch, xylitol and gum arabic.

In the research on the combination of xylitol and starch, lactitol and starch, xylitol and gum arabic, some factors needed in the process of preparing dripping pills by compound application of xylitol and starch were investigated, mainly xylose The influence of alcohol type, condensate and condensate temperature on the formability of drop pills, the effect of the ratio of xylitol and starch on the formability of drop pills, the influence of temperature on the formability of drop pills, the effect of the amount of extract on the formability of drop pills, and the effect of stirring time on the drop pill formability The impact of pill formability, the effect of dropper caliber on the particle size of drop pills, the formulation optimization of drop pills, the preliminary determination of drop pills, and the dissolution time limit were investigated. It is found that solid xylitol has three types: powder, granular and crystalline, and powder xylitol is the easiest to melt, and can be well dissolved and dispersed in the mixture formed by starch and extract, with good fluidity and easy dripping , granular and crystalline xylitol are not easy to melt, and their solubility is also slightly poor. The mixture formed by them with starch and extract has poor fluidity and high viscosity, and it is almost impossible to drip. Therefore, powder is the first choice in the process of dripping pills. Xylitol.

In the study of the influence of the ratio of auxiliary materials on the formability, it was found that in the combination of xylitol and starch, lactitol and starch, xylitol and gum arabic, the weight ratio of low melting point matrix auxiliary materials to plasticizing matrix auxiliary materials was 1: 0 to 1:1.5, preferably 1:0.1 to 1:0.9, most preferably 1:0.1 to 1:0.5. Within this range, the low-melting-point matrix auxiliary material, the plasticized matrix auxiliary material, and the molten drug matrix liquid can all drop out and condense. Specifically for each combination, the weight ratio of xylitol and starch is preferably 1: 0.2 to 1: 0.3, the weight ratio of lactitol to starch is preferably 1: 0.2 to 1: 0.3, and the weight ratio of xylitol and gum arabic The weight ratio is preferably 1:0.2 to 1:0.4. In the research on the influence of temperature on the formability of drop pills, it is found that temperature has a great influence on the formability of drop pills. When the temperature is too low, the dripping effect of the drop pills will be affected due to the viscosity of the matrix. When the temperature is too high , the dripping pills do not condense. In the study of the influence of stirring time on the formability of dropping pills, it was found that the stirring time can affect the formability of dropping pills. If the stirring time is too short, the fluidity will be poor, which will affect the dripping. If the stirring time is too long, the condensation of the dropping pills will be affected. At the dropping temperature, the stirring time can be within 1-120 minutes, and the more suitable stirring time is 10-30 minutes. Considering that the stirring time cannot be too short in industrial production, the method of stirring at low temperature for a long time and dripping at high temperature is adopted. In the study of the effect of dropper caliber on the particle size of dropping pills, it was found that the dropper caliber affects the size of dropping pills and the fluidity of the molten matrix, which affects the dripping effect. Dropping pills become smaller as the caliber becomes smaller, but after 1.4 mm, the particle size does not change significantly as the caliber becomes smaller, but the fluidity of the matrix decreases, which affects the dripping.

Therefore, in the preparation method of the preparation, the mixing and stirring time of the drug and the matrix excipients is 10-30 minutes; the heating and melting temperature of the drug and the matrix excipients after mixing is 45-115°C, the dripping temperature is 45-95°C, and the cooling liquid is liquid Paraffin, methyl silicone oil or vegetable oil (soybean oil, castor oil, etc.), the temperature of the cooling liquid is -20 ~ 25 ° C, the inner diameter of the dropper is 1.0 ~ 4.0 mm; the preferred heating melting temperature is 60 ~ 85 ° C, the dropping temperature 60-85°C, the condensing agent is liquid paraffin, methyl silicone oil, the condensing agent temperature is 0-18°C, the diameter of the dropper is 1.1-3.5 mm, and the difference between the outer diameter and inner diameter of the dropper is better; the best heating Methyl silicone oil with a melting temperature of 64°C, a dripping temperature of 64°C, a dropper diameter of 1.2 to 2.5 mm, and a condensing agent of 0°C.

The best matrix auxiliary material of the present invention is xylitol and starch, and the weight ratio of xylitol and starch is 1: 0.2～1: 0.3; Or is lactitol and starch, and the ratio of lactitol and starch is 1: 0.2～ 1:0.3; or xylitol and gum arabic, the weight ratio of xylitol and gum arabic is 1:0.2～1:0.4.

Xylitol is a natural plant sweetener, recognized by the World Health Organization, xylitol is one of the safest sweeteners, widely used in the fields of food and oral products all over the world, xylitol does not need to enter the cell With the help of insulin, it will not cause blood sugar to rise in the case of glucose utilization disorders, can improve the symptoms of diabetic patients, has a strong effect of inhibiting the production of ketone bodies, can promote the production of liver glycogen, directly penetrates into tissues to participate in metabolism, and can correct protein , Abnormal metabolism of fat and steroids; Xylose is an intermediate product of metabolism in the body, and the body has a high tolerance to it. Clinical practice has proved that the highest tolerated dose can reach 220g per day for oral administration, and 100g for daily intravenous infusion. The median lethal dose (LD50) for mice is 25700mg/Kg orally, 6400mg/Kg for intravenous injection, and 6200mg/Kg for rats.

In the medicine of the present invention, the dosage ratio of the matrix auxiliary material and the medicine can be within the range allowed by the pharmacy. The medicine described here can be the original medicinal material or the active ingredient extract of the medicine. The ratio range of the medicine refers to the weight ratio of the excipients and the drug extract, the weight ratio of the matrix excipients to the drug extract is 1:0.1～1:1; the preferred weight ratio of the matrix excipients to the drug extract The ratio is 1:0.1 to 1:0.6; the optimal weight ratio of matrix excipients to the extracted extract of the drug is 1:0.2 to 1:0.4.

The medicine of the present invention can be prepared by conventional methods of traditional Chinese medicine preparations. The active ingredients of the medicine of the present invention can be prepared by the following methods: water extraction, water extraction and alcohol precipitation, extraction, impregnation, percolation, reflux extraction, continuous reflux extraction, and macroporous resin adsorption. For example, these raw materials can be ground into powder and mixed uniformly to make powder for blunt administration; these drugs can also be decocted together, and then the decoction can be concentrated to make oral liquid; Effective, preferably raw material adopts following process to extract, but this can not limit protection scope of the present invention.

The preparation method of medicine of the present invention is as follows:

(a) Take Bupleurum 1-5%, Pinellia 15-20%, Scutellaria baicalensis 15-20%, Codonopsis 15-20%, Jujube 15-20%, Licorice 10-15%, Ginger 8-13% for later use ;

(b) Take Radix Bupleuri, distill and extract with water to obtain volatile oil and water decoction, add water to extract the remaining medicinal residues, combine with the water decoction obtained from the initial distillation, properly concentrate, let cool, add ethanol for precipitation, and let stand, Concentrate the supernatant and recover ethanol to obtain a concentrated solution (1) for later use; take pinellia and ginger, add ethanol for percolation, and concentrate the percolation solution to obtain a concentrated solution (2), for later use; take Codonopsis pilosula, jujube and licorice, and extract with water , add ethanol to precipitate, let stand, take the supernatant and concentrate and reclaim ethanol to obtain a concentrated solution (3), and set aside; take Scutellaria baicalensis, add water to extract, add dilute hydrochloric acid to the extract to adjust the pH value, keep warm, stand still, filter, and use ethanol for precipitation and water to adjust the pH value, and vacuum-dry to obtain the Scutellaria baicalensis extract; combine the obtained concentrated solutions of (1), (2), and (3), and continue to concentrate to form a thick paste (4);

(c) Add the above-mentioned thick paste (4), Scutellaria baicalensis extract, Bupleurum volatile oil to an appropriate amount of auxiliary materials, mix well, heat and melt the mixture at 45-115°C, stir evenly, and stir for 1-120 minutes, keep warm, and keep warm at 45°C Dropping at a temperature of ~95°C, the diameter of the dropper is 1.0-4.0 mm, drop into liquid paraffin, methyl silicone oil or vegetable oil at -20-25°C, and make drop pills.

The preferred preparation method of the medicament of the present invention comprises the following steps:

(a) Take the following medicinal materials according to the prescription: Bupleurum 3.7%, Pinellia 18.5%, Scutellaria baicalensis 18.5%, Codonopsis 18.5%, Jujube 18.5%, licorice 12.3%, ginger 10% for later use;

(b) Take Bupleurum bupleuri, add water to distill and extract 3 times, each extraction time is 3 hours, get volatile oil and water decoction, add water to extract the remaining medicinal residues 2 times, each time 1 hour, and decoct with water obtained from the initial distillation The liquids were combined, properly concentrated to a relative density of 1.20 at 50°C, allowed to cool, added ethanol to precipitate until the alcohol content reached 70%, left to stand, and the supernatant was concentrated to recover ethanol to obtain a concentrated solution (1), which was set aside; and ginger, add 70% ethanol for percolation, concentrate the percolation liquid to obtain concentrated solution (2), set aside, take Codonopsis pilosula, jujube and licorice, add water to extract 3 times, each time for 1 hour, combine the extracts and concentrate to 50 °C The relative density is 1.18, add ethanol to precipitate until the alcohol content reaches 60%, let it stand, take the supernatant and concentrate and recover the ethanol to obtain a concentrated solution (3), and set aside; take Scutellaria baicalensis, add 10 times the amount of water to extract twice, each time 1 Hours, add dilute hydrochloric acid to the extract to adjust the pH value to 1.8, keep it warm at 80°C, let it stand, filter, adjust the pH value to 5.5 with ethanol and water for the precipitate, and dry it in vacuum to obtain the Scutellaria baicalensis extract; the obtained (1), ( 2), (3) the concentrates are combined and continue to concentrate into a thick paste (4);

(c) Add the above-mentioned thick paste (4), Scutellaria baicalensis extract, Bupleurum volatile oil to an appropriate amount of auxiliary materials, mix well, heat and melt the mixture at 60-85°C, stir evenly, the stirring time is 10-30 minutes, keep warm, and keep warm at 60°C Dropping at a temperature of ~85°C, the diameter of the dropper is 1.1~3.5mm, drop into liquid paraffin and methyl silicone oil at 0~18°C, drain the formed drop pills and wipe off the cooling liquid, and pack after drying , made into dripping pills, that is to say.

The best pharmaceutical preparation method of the present invention comprises the following steps:

(a) Take the following medicinal materials according to the prescription: Bupleurum 3.7%, Pinellia 18.5%, Scutellaria baicalensis 18.5%, Codonopsis 18.5%, Jujube 18.5%, licorice 12.3%, ginger 10% for later use;

(b) Take Bupleurum bupleuri, add water to distill and extract 3 times, each extraction time is 3 hours, get volatile oil and water decoction, add water to extract the remaining medicinal residues 2 times, each time 1 hour, and decoct with water obtained from the initial distillation The liquids were combined, properly concentrated to a relative density of 1.20 at 50°C, allowed to cool, added ethanol to precipitate until the alcohol content reached 70%, left to stand, and the supernatant was concentrated to recover ethanol to obtain a concentrated solution (1), which was set aside; and ginger, add 70% ethanol for percolation, concentrate the percolation solution to obtain a concentrated solution (2), and set aside; take Codonopsis pilosula, jujube and licorice, add water to extract 3 times, each time for 1 hour, and combine the extracts and concentrate to 50 ° C The relative density is 1.18, add ethanol to precipitate until the alcohol content reaches 60%, let it stand, take the supernatant and concentrate and recover the ethanol to obtain a concentrated solution (3), and set aside; take Scutellaria baicalensis, add 10 times the amount of water to extract twice, each time 1 Hours, add dilute hydrochloric acid to the extract to adjust the pH value to 1.8, keep it warm at 80°C, let it stand, filter, adjust the pH value to 5.5 with ethanol and water for the precipitate, and dry it in vacuum to obtain the Scutellaria baicalensis extract; the obtained (1), ( 2), (3) the concentrates are combined and continue to concentrate into a thick paste (4);

Wherein the Bupleurum bupleurum distillation time in step (b) is 1～5 hours, preferred scope is 2～4 hours, and optimum time is 3 hours. 0.5 to 1.5 hours, the best time is 1 hour; concentrate the extract to a relative density of 1.10 to 1.15 at 50°C; ethanol precipitation to an alcohol content of 50 to 90%, preferably 60 to 80%, the best condition 70%; in the step (b), the concentration of the percolate of Pinellia fragrans and ginger is 50% to 90%. The preferred range is 60 to 80%, and the optimal condition is 70%; in step (b), Codonopsis pilosula, jujube and licorice are extracted 2 to 4 times, and the optimal condition is 3 times; each time is 0.5 to 1.5 hours, the most The optimum condition is 1 hour; the concentration of the extract to a relative density of 1.15 to 1.20 at 50°C; ethanol precipitation to an alcohol content of 40 to 80%, preferably in the range of 50 to 70%, and the best condition to 60%; step (d ), the amount of water added to Scutellaria baicalensis is 5 to 15 times, the preferred range is 8 to 12 times, and the optimal condition is 10 times; the pH value is adjusted by hydrochloric acid to 1.0 to 2.5, and the optimal condition is 1.5 to 2.0; the heat preservation is at 60 to 100°C , the preferred condition is 70-90°C, the optimum condition is 80°C; the pH value is adjusted to 4-7 with ethanol and water for precipitation, and the optimum condition is 5-6; in step (b), the combined concentrated solution continues to concentrate to a relative density of 1.25 to 1.30 at 70°C;

The above components can be increased or decreased according to the corresponding proportion during production. For example, the unit of kilogram or ton can be used for large-scale production, and the unit of gram can also be used for small-scale production, and the weight can be increased or decreased. The weight ratio of crude drug materials between them remains unchanged.

The single traditional Chinese medicines in the above compositions, especially the adjuvant medicines, herbal medicines or adjuvant medicines and herbal medicines, can be replaced by appropriate traditional Chinese medicines with the same properties and efficacy alone or at the same time, and the traditional Chinese medicine preparations and their medicinal effects will remain unchanged after the replacement.

When the medicine of the present invention is used, the usage and dosage can be determined according to the patient's condition, and can be used 1-3 times a day, and the daily dosage of each crude drug is based on the dosage in the national pharmacopoeia, and does not exceed the prescribed amount in the pharmacopoeia.

The dripping pill prepared by the present invention, in addition to having the advantages of conventional dropping pills such as simple preparation, stable quality, solidification of liquid medicine, convenient administration, high efficiency and quick effect, its biggest advantage is:

1, the selected auxiliary materials of the present invention have a high degree of pure nature: the base auxiliary materials used in the present invention are derived from natural plants or based on the base auxiliary materials of natural plant sources, and the selected base auxiliary materials are xylitol and starch or lactitol and Starch or xylitol and gum arabic, this matrix auxiliary material has a high degree of naturalness, low toxic and side effects, good taste, short dissolution time, and quick effect. It is a new type of matrix auxiliary material that can be used to replace the current chemical synthesis auxiliary material , the dripping pill that this auxiliary material is made can solve the problem that the pure natural degree that drop pill base is faced at present is low, more and more can't satisfy people's requirement to return to nature, take the pure natural medicine of low toxicity, no side effect.

2. Solve some problems in the export of traditional Chinese medicine: the medicine of the present invention can also solve some problems encountered in the export process of Chinese medicine preparations, especially dripping pill preparations, because different countries, especially industrially developed European countries, are not interested in traditional Chinese medicine. The different identifications of the excipients selected for the drop pill preparations overcome the defect that polyethylene glycol, the excipient selected for the drop pill preparations exported as health food, is not in the food additive catalog of some countries, and improve the Chinese medicine drop pill preparations to the international market. Enhance the competitiveness of the international market.

3. Solve the problem of poor taste of dripping pill preparations and further improve the speed of drug onset (dissolution time limit): the drug dripping pills of the present invention made of such matrix auxiliary materials can improve the taste of traditional Chinese medicine preparations, especially the current dripping pill preparations Bad shortcoming, improve mouthfeel, be accepted by patient more easily, and the dropping pill that adopts the selected auxiliary material of medicine of the present invention to make has shorter dissolving time limit, makes medicine onset faster, is a kind of onset faster A medicine for treating alternating cold and heat, fullness in the chest and hypochondrium, vexation and vomiting, bitter mouth and dry throat.

4. Higher security and solve some problems in the storage of dripping pills: the matrix selected by the present invention is not only additives and nutrients commonly used in the food industry, but also can be used as medicine, but it has not been used as medicine Therefore, it is absolutely safe and has no toxic side effects in terms of the matrix. A large number of experiments have proved that the dropping pills made of this auxiliary material can reduce the precipitation of active ingredients during storage, the dropping pills stick to the pills, and are easy to absorb moisture and become soft. And other shortcomings, can be suitable for industrialized large-scale production.

In order to better understand the present invention, the dissolution time limit, difference in weight of pills, softness and hardness of dripping pills, and sticky pills Tests such as etc. illustrate the advantages of the present invention.

Experimental example 1: Comparative experimental example of dissolution time limit and pill weight difference

in vitro test

The present invention is compared with Xiaochaihu dripping pills made of polyethylene glycol as an auxiliary material. By measuring the dissolution time limit, its good release effect is investigated; Suitable for industrial production.

1. Test medication: the new matrix of the present invention, Xiaochaihu dripping pills (new), and the Xiaochaihu dropping pills (old) made with polyethylene glycol as an auxiliary material.

2. Methods and results:

Dissolution time limit: determined according to the method under this item of "Chinese Pharmacopoeia"; difference in pill weight: determined according to the method under this item of "Chinese Pharmacopoeia". The test results are shown in Table 1.

Table 1 Comparison of the dissolution time and weight difference between three batches of Xiaochaihu dripping pills (new) made with new matrix excipients and Xiaochaihu dripping pills (old) made with polyethylene glycol 6000 as excipients

The test data show that the dissolution time of the new matrix Xiaochaihu dripping pills is shorter than that of Xiaochaihu dripping pills made with polyethylene glycol; within the range. The test results show that the Xiaochaihu dripping pills made of new excipients dissolve faster, which is more conducive to the drug taking effect in the shortest time. Chemically synthesized auxiliary materials can be industrialized.

Test Example 2: Comparative observation of the present invention and Xiaobupleurum dripping pills made of polyethylene glycol 6000 for hardness and stickiness of dripping pills

The present invention is compared with Xiaobupleurum dripping pills made of polyethylene glycol as an auxiliary material, and its effect is investigated by measuring the above-mentioned indicators.

1. Test medication: the new matrix Xiaochaihu dripping pills (new) of the present invention is provided by Tianjin Jinshili Drug Research and Development Co., Ltd.; the Xiaochaihu dripping pills (old) made of polyethylene glycol as an auxiliary material are provided by Tianjin Jinshili Provided by Drug Research and Development Ltd.

2. Methods and results:

Take three batches of new and old matrix Xiaochaihu dripping pills, put them in porcelain bottles respectively, and seal them with bottle stoppers. It is put into the desiccator that has saturated Nacl (humidity 75%) solution at the bottom, then desiccator is put into constant temperature 40 ℃ drying box, regularly takes a sample, observes situations such as dripping pill softness hardness, dripping pill sticking pill, the result See Table 2.1 and Table 2.2.

Table 2.1 Observation and comparison of three batches of Xiaochaihu dripping pills made with polyethylene glycol 6000 as auxiliary material

Table 2.2: Observation and comparison of three batches of Xiaochaihu dripping pills (new) made with new matrix excipients and Xiaochaihu dripping pills (old) made with polyethylene glycol 6000 as excipients

The test data showed that the change of softness and hardness of the new matrix Xiaochaihu dripping pills was similar to that of the Xiaochaihu dripping pills made of polyethylene glycol, but slightly stronger; Xiao Bupleurum drop pills made with polyethylene glycol as auxiliary materials are similar. The test results show that the change of stickiness and hardness of Xiaochaihu dripping pills made of old and new matrix excipients are similar, indicating that this natural matrix excipient can replace the current chemically synthesized excipients and can be produced industrially.

In vivo test:

This test demonstrates the beneficial effects of the present invention through the antiviral effect in vivo.

In the experiment, healthy Kunming mice were selected, half male and half male, and the female was not pregnant, with a body weight of 14-16g. After being stratified according to body weight, they were randomly divided into normal control group (no administration by intragastric administration), model control group (administration of distilled water by intragastric administration), ribavirin control group (administration of ribavirin 0.07g/kg intramuscularly) and Xiaochaihu Decoction Dropping pill control group (gavage to Xiaochaihu Tangwan 1.2g/kg). 16 animals per group. Two days after each group was administered according to different groups and doses (twice/day), except for the normal control group, the other mice were lightly anesthetized with ether and infected with 10LD ₅₀ influenza virus (FM ₁ ) drop nasally. After allowing it to wake up naturally, the administration was continued for 4 consecutive days (6 days in total). Observe the animal's activities, eating, coat color, defecation, etc. every day, and record the number of dead animals (dead animals should be weighed immediately and dissected, and the lungs should be taken out for wet weight, and the lung index should be calculated one by one, and the lung index inhibition rate should be obtained) . On the fourth day after administration of the virus, the animals were fasted for 8 hours, weighed the body weight of each animal, dissected the mouse lungs and weighed the wet weight, calculated the lung index one by one, and obtained the inhibition rate of the lung index.

Lung index = wet lung weight (g) ÷ body weight (g) × 100

Lung index inhibition rate = (mean value of lung index of virus control group - mean value of lung index of test group) ÷ mean value of lung index of virus control group × 100%

The larger the lung index value, the more serious the lung disease. The results are listed in the table below after statistical processing.

Effects of Biaoxiaochaihutang Dropping Pills on Pulmonary Lesions of Mice Infected with Influenza Virus (FM1 Strain)

Compared with the model control group: **P<0.01.

It can be seen from the above table that for the viral pneumonia caused by influenza virus infection in mice, the Xiaochaihutang dripping pill group can reduce the lung index and increase the inhibition rate of the lung index. Compared with the virus model group, P<0.01, have very significant differences.

Detailed ways

The present invention will be further described below in conjunction with specific examples, and the following examples are only used to illustrate the present invention and do not limit the present invention.

Example 1

(a) Take 33.3g of Bupleurum, 166.7g of Pinellia chinensis, 166.7g of Scutellaria baicalensis, 166.7g of Codonopsis pilosula, 166.7g of jujube, 111.1g of licorice, 88.9g of ginger, 65.5g of xylitol, and 18.5g of gum arabic;

(b) Take Bupleurum bupleuri, add water to distill and extract 3 times, each extraction time is 3 hours, get volatile oil and water decoction, add water to extract the remaining medicinal residues 2 times, each time 1 hour, and decoct with water obtained from the initial distillation The liquids were combined, properly concentrated to a relative density of 1.20 at 50°C, allowed to cool, added ethanol to precipitate until the alcohol content reached 70%, left to stand, and the supernatant was concentrated to recover ethanol to obtain a concentrated solution (1), which was set aside; and ginger, add 70% ethanol for percolation, concentrate the percolation liquid to obtain concentrated solution (2), set aside, take Codonopsis pilosula, jujube and licorice, add water to extract 3 times, each time for 1 hour, combine the extracts and concentrate to 50 °C The relative density is 1.18, add ethanol to precipitate until the alcohol content reaches 60%, let it stand, take the supernatant and concentrate and recover the ethanol to obtain a concentrated solution (3), and set aside; take Scutellaria baicalensis, add 10 times the amount of water to extract twice, each time 1 Hours, add dilute hydrochloric acid to the extract to adjust the pH value to 1.8, keep it warm at 80°C, let it stand, filter, adjust the pH value to 5.5 with ethanol and water for the precipitate, and dry it in vacuum to obtain the Scutellaria baicalensis extract; the obtained (1), ( 2), (3) the concentrates are combined and continue to concentrate into a thick paste (4);

(c) Add the above-mentioned thick paste (4), Scutellaria baicalensis extract, Bupleurum volatile oil to the xylitol and starch mixture, mix thoroughly, heat and melt the mixture at 105-115°C, stir evenly, the stirring time is 10 minutes, keep warm, Dropping at a temperature of 62-66°C, the diameter of the dropper is 1.20-2.0 mm, drop into methyl silicone oil at 0-8°C, and make drop pills.

Example 2

(a) Take Bupleurum 33.3g, Pinellia 166.7g, Scutellaria baicalensis 166.7g, Codonopsis 166.7g, Chinese jujube 166.7g, licorice 111.1g, ginger 88.9g, xylitol, and gum arabic;

(b) Take Radix Bupleurum, add water to distill and extract once for 3 hours to obtain volatile oil and water decoction, add water to extract the remaining medicinal dregs once for 1 hour, and combine with the water decoction obtained from the initial distillation , properly concentrated to a relative density of 1.10 at 50°C, let cool, add ethanol to precipitate until the alcohol content reaches 50%, let it stand, take the supernatant to concentrate and recover the ethanol to obtain a concentrated solution, and set aside; take pinellia and ginger, add 50 % of ethanol percolation, concentrate percolation liquid to obtain concentrated liquid, set aside; take Codonopsis pilosula, jujube and licorice, add water to extract 3 times, each time for 1 hour, combine the extracts and concentrate to a relative density of 1.18 at 50°C, add ethanol to precipitate When the alcohol content reaches 60%, let it stand still, take the supernatant, concentrate and recover the ethanol to obtain a concentrated solution, and set aside; take Scutellaria baicalensis, add 10 times the amount of water to extract twice, each time for 1 hour, add dilute hydrochloric acid to the extract to adjust the pH value 1.0, keep warm at 60°C, stand still, filter, adjust the pH value to 4.0 with ethanol and water for precipitation, and dry in vacuum to obtain the extract of Scutellaria baicalensis; combine the concentrates and continue to concentrate to form a thick paste, with a relative density of 1.25 at 70°C for later use;

(c) Mix the above-mentioned Scutellaria baicalensis extract, bupleurum volatile oil and thick ointment with 5 times the amount of the extract, xylitol: gum arabic at a ratio of 5:1, mix the mixture evenly, heat and melt the mixture at 60-85°C, and stir evenly , the stirring time is 10-30 minutes, keep warm, drip at a temperature of 60-85 ° C, drop the pipette diameter of 1.1-3.5 mm, drop into the methyl silicone oil of 0-18 ° C, drain the formed drop pills and put them together. Wipe off the cooling liquid, subpackage after drying, and make drop pills.

Example 3

(a) Take Bupleurum 33.3g, Pinellia 166.7g, Scutellaria baicalensis 166.7g, Codonopsis 166.7g, Chinese jujube 166.7g, licorice 111.1g, ginger 88.9g, lactitol, and starch for later use;

(b) Take Radix Bupleurum, add water to distill and extract 2 times, each extraction time is 3 hours, get volatile oil and water decoction, add water to extract the remaining medicinal residues 2 times, each time 1.5 hours, and decoct with water obtained from the initial distillation The liquids were combined, properly concentrated to a relative density of 1.30 at 50°C, allowed to cool, added ethanol to precipitate until the alcohol content reached 50%, left to stand, and the supernatant was concentrated to recover the ethanol to obtain a concentrated solution (1), which was set aside; and ginger, add 60% ethanol for percolation, concentrate the percolation solution to obtain a concentrated solution (2), set aside, take Codonopsis pilosula, jujube and licorice, add water to extract twice, each time for 0.5 hours, combine the extracts and concentrate to 50 °C The relative density is 1.18, add ethanol to precipitate until the alcohol content reaches 50%, let it stand, take the supernatant and concentrate and recover the ethanol to obtain a concentrated solution (3), and set aside; take Scutellaria baicalensis, add 8 times the amount of water to extract 2 times, each time 1 Hours, add dilute hydrochloric acid to the extract to adjust the pH value to 1.5, keep it warm at 70°C, let it stand, filter, adjust the pH value to 5.0 with ethanol and water for the precipitate, and dry it in vacuum to obtain the Scutellaria baicalensis extract; the obtained (1), ( 2), (3) the concentrates are combined and continue to concentrate into a thick paste (4);

(c) Add the above-mentioned thick paste (4), scutellaria baicalensis extract, Bupleurum volatile oil to an appropriate amount of auxiliary materials, mix well, heat and melt the mixture at 90-95°C, stir evenly, the stirring time is 10 minutes, keep warm, keep warm at 62-65°C Dropping at ℃ temperature, the diameter of the dropper is 1.21-2.5 mm, drop into the liquid paraffin at 0-8 ℃, drain the formed drop pills and wipe off the cooling liquid, pack them after drying, and make drop pills. Instantly.

Example 4

(a) Take Bupleurum 33.3g, Pinellia 166.7g, Scutellaria baicalensis 166.7g, Codonopsis 166.7g, Jujube 166.7g, Licorice 111.1g, Ginger 88.9g, Sorbitol 56.8g, Xanthan gum 26.2g for later use;

(b) Take Bupleurum bupleuri, add water to distill and extract 4 times, each extraction time is 3 hours, get volatile oil and water decoction, add water to extract the remaining medicinal residues 3 times, each time 1 hour, and decoct with water obtained from the initial distillation The liquids were combined, properly concentrated to a relative density of 1.40 at 50°C, allowed to cool, added ethanol to precipitate until the alcohol content reached 80%, left to stand, and the supernatant was concentrated and the ethanol was recovered to obtain a concentrated solution (1), which was set aside; and ginger, add 80% ethanol for percolation, concentrate the percolation solution to obtain a concentrated solution (2), and set aside; take Codonopsis pilosula, jujube and licorice, add water to extract 4 times, each time for 1.5 hours, and combine the extracts and concentrate to 50 ° C The relative density is 1.19, add ethanol to precipitate until the alcohol content reaches 70%, let it stand, take the supernatant, concentrate and recover the ethanol to obtain a concentrated solution (3), and set aside; take Scutellaria baicalensis, add 12 times the amount of water to extract 2 times, each time 1 Hours, add dilute hydrochloric acid to the extract to adjust the pH value to 2.0, keep it warm at 90°C, let it stand, filter, adjust the pH value to 5.0 with ethanol and water for the precipitate, and dry it in vacuum to obtain the Scutellaria baicalensis extract; the obtained (1), ( 2), (3) the concentrates are combined and continue to concentrate into a thick paste (4);

(c) Add the above-mentioned thick cream (4), Scutellaria baicalensis extract, and Bupleurum volatile oil to the mixture of sorbitol and xanthan gum, mix well, heat and melt the mixture at 64°C, stir evenly, the stirring time is 10-30 minutes, keep warm, Drop at a temperature of 64°C, with a dropper diameter of 1.2-2.5mm, drop into methyl silicone oil at 0°C, drain the formed droplet pills and wipe off the cooling liquid, pack them after drying, and make droplet pills , that is.

Example 5

(a) Take 33.3g of Bupleurum, 166.7g of Pinellia chinensis, 166.7g of Scutellaria baicalensis, 166.7g of Codonopsis pilosula, 166.7g of jujube, 111.1g of licorice, 88.9g of ginger, 85.6g of trehalose, and 21.4g of cyclodextrin for later use;

(b) Take Radix Bupleurum, add water to distill and extract 5 times, each extraction time is 3 hours, get volatile oil and water decoction, add water to extract the remaining medicinal residues 2 times, each time 1 hour, and decoct with water obtained from the initial distillation The liquids were combined, properly concentrated to a relative density of 1.20 at 50°C, allowed to cool, added ethanol to precipitate until the alcohol content reached 70%, left to stand, and the supernatant was concentrated to recover ethanol to obtain a concentrated solution (1), which was set aside; and ginger, add 70% ethanol for percolation, concentrate the percolation solution to obtain a concentrated solution (2), and set aside; take Codonopsis pilosula, jujube and licorice, add water to extract 3 times, each time for 1 hour, and combine the extracts and concentrate to 50 ° C The relative density is 1.18, add ethanol to precipitate until the alcohol content reaches 60%, let it stand, take the supernatant and concentrate and recover the ethanol to obtain a concentrated solution (3), and set aside; take Scutellaria baicalensis, add 10 times the amount of water to extract twice, each time 1 Hours, add dilute hydrochloric acid to the extract to adjust the pH value to 1.8, keep it warm at 80°C, let it stand, filter, adjust the pH value to 5.5 with ethanol and water for the precipitate, and dry it in vacuum to obtain the Scutellaria baicalensis extract; the obtained (1), ( 2), (3) the concentrates are combined and continue to concentrate into a thick paste (4);

(c) Add the above-mentioned thick paste (4), Scutellaria baicalensis extract, and Bupleurum volatile oil to the mixture of trehalose and cyclodextrin, mix well, heat and melt the mixture at 85-93°C, stir evenly, the stirring time is 15 minutes, and keep warm , at a temperature of 60-65°C, the dropper diameter is 1.6-3.5mm, drop into the methyl silicone oil at 0-18°C, drain the formed dripping pills and wipe off the cooling liquid, and pack them after drying , made into dripping pills, that is to say.

Example 6

(a) Take Bupleurum 33.3g, Pinellia 166.7g, Scutellaria baicalensis 166.7g, Codonopsis 166.7g, jujube 166.7g, licorice 111.1g, ginger 88.9g, lactitol 101.5g, and hydroxypropyl starch 15.6g for later use; Bupleurum bupleurum, distilled and extracted twice with water, each extraction time is 3 hours, to obtain volatile oil and water decoction, add water to the remaining medicinal residue

(b) extract 2 times, each time for 1 hour, combine with the water decoction obtained from the initial distillation, properly concentrate to a relative density of 1.20 at 50°C, let it cool, add ethanol to precipitate until the alcohol content reaches 90%, let it stand, Concentrate the supernatant and recycle ethanol to obtain a concentrated solution (1), which is set aside; take pinellia and ginger, add 90% ethanol for percolation, and concentrate the percolated solution to obtain a concentrated solution (2), which is set aside; take Codonopsis pilosula, jujube and licorice , add water and extract 3 times, each time for 1 hour, the combined extracts are concentrated to a relative density of 1.18 at 50°C, add ethanol to precipitate until the alcohol content reaches 60%, leave standstill, take the supernatant and concentrate and recycle the ethanol to obtain a concentrated solution (3 ), set aside; take Scutellaria baicalensis, add 10 times the amount of water to extract twice, 1 hour each time, add dilute hydrochloric acid to the extract to adjust the pH value to 1.8, keep it warm at 80°C, let it stand, filter, and adjust the pH value with ethanol and water for precipitation to 5.5, vacuum-dried to obtain the Scutellaria baicalensis extract; the resulting (1), (2), (3) concentrates were combined, and continued to concentrate into a thick paste (4);

(c) Add the above-mentioned thick cream (4), baicalin extract, Bupleurum volatile oil to the mixture of lactitol and hydroxypropyl starch, mix well, heat and melt the mixture at 70-75°C, stir evenly, the stirring time is 60 minutes, keep warm , drop at a temperature of 50-55 °C, dropper diameter is 1.8-2.5 mm, drop into liquid paraffin at 0-10 °C, drain the formed dripping pills and wipe off the cooling liquid, pack after drying, Made into drop pills, that is, too.

Example 7

(a) Take Bupleurum 33.3g, Pinellia 166.7g, Scutellaria baicalensis 166.7g, Codonopsis 166.7g, Chinese jujube 166.7g, licorice 111.1g, ginger 88.9g, xylitol and methylcellulose for later use;

(b) Take Radix Bupleurum, add water to distill and extract 2 times, each extraction time is 3 hours, get volatile oil and water decoction, add water to extract the remaining medicinal residues 2 times, each time 1 hour, decoct with water obtained from the start of distillation The liquids were combined, properly concentrated to a relative density of 1.40 at 50°C, allowed to cool, added ethanol to precipitate until the alcohol content reached 80%, left to stand, and the supernatant was concentrated and the ethanol was recovered to obtain a concentrated solution (1), which was set aside; and ginger, add 80% ethanol for percolation, concentrate the percolation solution to obtain a concentrated solution (2), set aside, take Codonopsis pilosula, jujube and licorice, add water to extract 3 times, each time for 1 hour, combine the extracts and concentrate to 50 ° C The relative density is 1.18, add ethanol to precipitate until the alcohol content reaches 60%, let it stand, take the supernatant and concentrate and recover the ethanol to obtain a concentrated solution (3), and set aside; take Scutellaria baicalensis, add 10 times the amount of water to extract twice, each time 1 Hours, add dilute hydrochloric acid to the extract to adjust the pH value to 1.8, keep it warm at 80°C, let it stand, filter, adjust the pH value to 5.5 with ethanol and water for the precipitate, and dry it in vacuum to obtain the Scutellaria baicalensis extract; the obtained (1), ( 2), (3) the concentrates are combined, and continue to concentrate to form a thick paste (4), with a relative density of 1.27 at 70°C;

(c) Add 6 times the amount of excipients with a xylitol:methylcellulose ratio of 1:0.3 to the above-mentioned thick paste (4), Scutellaria baicalensis extract, and Bupleurum volatile oil, mix well, and heat the mixture at 72-75°C Melt, stir evenly, stir for 40 minutes, keep warm, drip at a temperature of 60-86°C, drop the dropper with a diameter of 1.2-2.0 mm, drop it into methyl silicone oil at 3°C, drain the formed drop pills and wipe Remove the cooling liquid, subpackage after drying, and make drop pills.

Example 8

(a) Take Bupleurum 33.3g, Pinellia 166.7g, Scutellaria baicalensis 166.7g, Codonopsis 166.7g, Jujube 166.7g, Licorice 111.1g, Ginger 88.9g, xylitol, and starch for later use;

(b) Take Bupleurum bupleuri, add water to distill and extract 3 times, each extraction time is 3 hours, get volatile oil and water decoction, add water to extract the remaining medicinal residues 2 times, each time 1 hour, and decoct with water obtained from the initial distillation The liquids were combined, properly concentrated to a relative density of 1.40 at 50°C, allowed to cool, added ethanol to precipitate until the alcohol content reached 60%, left to stand, and the supernatant was concentrated to recover ethanol to obtain a concentrated solution (1), which was set aside; and ginger, add 80% ethanol for percolation, concentrate the percolation solution to obtain a concentrated solution (2), set aside, take Codonopsis pilosula, jujube and licorice, add water to extract 3 times, each time for 1 hour, combine the extracts and concentrate to 50 ° C The relative density is 1.18, add ethanol to precipitate until the alcohol content reaches 700%, let it stand, take the supernatant and concentrate and recover the ethanol to obtain a concentrated solution (3), and set aside; take Scutellaria baicalensis, add 15 times the amount of water to extract 2 times, each time 1 Hours, add dilute hydrochloric acid to the extract to adjust the pH value to 1.8, keep it warm at 80°C, let it stand, filter, adjust the pH value to 7 with ethanol and water for the precipitate, and dry it in vacuum to obtain the Scutellaria baicalensis extract; the obtained (1), ( 2), (3) the concentrates are combined, and continue to concentrate to form a thick paste (4), with a relative density of 1.30 at 70°C;

(c) Add 5 times the amount of xylitol:starch to the mixture of 1:0.25 xylitol:starch into the above-mentioned thick paste (4), Scutellaria baicalensis extract, Bupleurum volatile oil, mix well, heat and melt the mixture at 60-85°C, stir Evenly, stir for 10-30 minutes, keep warm, drop at a temperature of 60-85°C, drop the pipette with a diameter of 1.1-3.5 mm, drop into methyl silicone oil at 0°C, drain and wipe Remove the cooling liquid, subpackage after drying, and make drop pills.

Example 9

(a) Take Bupleurum 33.3g, Pinellia 166.7g, Scutellaria baicalensis 166.7g, Codonopsis 166.7g, Chinese jujube 166.7g, licorice 111.1g, ginger 88.9g, lactitol, and starch for later use;

(b) Take Radix Bupleurum, add water to distill and extract 2 times, each extraction time is 3 hours, to obtain volatile oil and water decoction, add water to extract the remaining medicinal residues 3 times, each time 1.5 hours, and decoct with water obtained from the initial distillation The liquids were combined, properly concentrated to a relative density of 1.50 at 50°C, allowed to cool, added ethanol to precipitate until the alcohol content reached 50%, left to stand, and the supernatant was concentrated to recover ethanol to obtain a concentrated solution (1), which was set aside; and ginger, add 90% ethanol to percolate, concentrate the percolate to obtain concentrated solution (2), set aside, take Codonopsis pilosula, jujube and licorice, add water to extract 4 times, each time for 1.5 hours, combine the extracts and concentrate to 50 °C The relative density is 1.18, add ethanol to precipitate until the alcohol content reaches 60%, let it stand, take the supernatant and concentrate and recover the ethanol to obtain a concentrated solution (3), and set aside; take Scutellaria baicalensis, add 10 times the amount of water to extract twice, each time 1 After 1 hour, add dilute hydrochloric acid to the extract to adjust the pH value to 2.5, keep it warm at 80°C, let it stand, filter, adjust the pH value to 7 with ethanol and water for the precipitate, and dry it in vacuum to obtain the Scutellaria baicalensis extract; the obtained (1), ( 2), (3) the concentrates are combined, and continue to concentrate to form a thick paste (4), with a relative density of 1.27 at 70°C;

(c) Add 5 times the amount of auxiliary materials with lactitol:starch ratio of 1:0.3 to the above-mentioned thick paste (4), Scutellaria baicalensis extract, and Bupleurum volatile oil, mix well, heat and melt the mixture at 85°C, stir evenly, and stir The time is 10 to 30 minutes, keep warm, drip at 65 °C, the diameter of the dropper is 1.7 mm, drop into the methyl silicone oil at -10 ~ 5 °C, drain the formed drop pills and wipe off the cooling liquid. After drying, subpackage and make drop pills.

Example 10

(a) Take Bupleurum 33.3g, Pinellia 166.7g, Scutellaria baicalensis 166.7g, Codonopsis 166.7g, Chinese jujube 166.7g, licorice 111.1g, ginger 88.9g, xylitol, and gum arabic;

(b) Take Bupleurum bupleuri, add water to distill and extract 4 times, each extraction time is 3 hours, get volatile oil and water decoction, add water to extract the remaining medicinal residues 2 times, each time 1 hour, and decoct with water obtained from the initial distillation The liquids were combined, properly concentrated to a relative density of 1.20 at 50°C, allowed to cool, added ethanol to precipitate until the alcohol content reached 70%, left to stand, and the supernatant was concentrated to recover ethanol to obtain a concentrated solution (1), which was set aside; and ginger, add 70% ethanol for percolation, concentrate the percolation liquid to obtain concentrated solution (2), set aside, take Codonopsis pilosula, jujube and licorice, add water to extract 3 times, each time for 1 hour, combine the extracts and concentrate to 50 °C The relative density is 1.18, add ethanol to precipitate until the alcohol content reaches 60%, let it stand, take the supernatant and concentrate and recover the ethanol to obtain a concentrated solution (3), and set aside; take Scutellaria baicalensis, add 10 times the amount of water to extract twice, each time 1 Hours, add dilute hydrochloric acid to the extract to adjust the pH value to 1.8, keep it warm at 80°C, let it stand, filter, adjust the pH value to 5.5 with ethanol and water for the precipitate, and dry it in vacuum to obtain the Scutellaria baicalensis extract; the obtained (1), ( 2), (3) the concentrates are combined, and continue to concentrate to form a thick paste (4), with a relative density of 1.28 at 70°C;

(c) Add 3 times the amount of excipients with xylitol: gum arabic ratio of 1:0.4 to the above-mentioned thick paste (4), Scutellaria baicalensis extract, and Bupleurum volatile oil, mix well, heat and melt the mixture at 75°C, and stir evenly , the stirring time is 50 minutes, heat preservation, dripping at 70 °C, the diameter of the dropper is 1.21 mm, drop into the methyl silicone oil at 5 °C, drain the formed dripping pills and wipe off the cooling liquid, after drying Subpackage, make drop pills, that is to say.

Example 11

(a) Take 27g Bupleurum, 144g Pinellia, 180g Scutellaria, 180g Codonopsis, 180g Jujube, 90g Glycyrrhizae, 99g Ginger, xylitol, and chitin for later use;

(b) Take Bupleurum bupleuri, add water to distill and extract 3 times, each extraction time is 3 hours, get volatile oil and water decoction, add water to extract the remaining medicinal residues 2 times, each time 1 hour, and decoct with water obtained from the initial distillation The liquids were combined, properly concentrated to a relative density of 1.20 at 50°C, allowed to cool, added ethanol to precipitate until the alcohol content reached 70%, left to stand, and the supernatant was concentrated to recover ethanol to obtain a concentrated solution (1), which was set aside; and ginger, add 70% ethanol for percolation, concentrate the percolation liquid to obtain concentrated solution (2), set aside, take Codonopsis pilosula, jujube and licorice, add water to extract 3 times, each time for 1 hour, combine the extracts and concentrate to 50 °C The relative density is 1.18, add ethanol to precipitate until the alcohol content reaches 60%, let it stand, take the supernatant and concentrate and recover the ethanol to obtain a concentrated solution (3), and set aside; take Scutellaria baicalensis, add 10 times the amount of water to extract twice, each time 1 Hours, add dilute hydrochloric acid to the extract to adjust the pH value to 1.8, keep it warm at 80°C, let it stand, filter, adjust the pH value to 5.5 with ethanol and water for the precipitate, and dry it in vacuum to obtain the Scutellaria baicalensis extract; the obtained (1), ( 2), (3) the concentrates are combined, and continue to concentrate to form a thick paste (4), with a relative density of 1.28 at 70°C;

(c) Add 5.5 times the amount of xylitol:chitin as 1:0.6 excipients to the above-mentioned thick paste (4), Scutellaria baicalensis extract, and Bupleurum volatile oil, mix well, heat and melt the mixture at 100°C, and stir evenly , the stirring time is 5 minutes, keep warm, drip at 85 ° C, the diameter of the dropper is 1.1 mm, drop into the methyl silicone oil at 0 ° C, drain the formed dripping pills and wipe off the cooling liquid, after drying Subpackage, make drop pills, that is to say.

Example 12

(a) Get Bupleurum 45g, Pinellia 153g, Scutellaria baicalensis 171g, Codonopsis 171g, Jujube 171g, Radix Glycyrrhiza 99g, Ginger 90g, lactitol, red alginate for later use;

(b) Take Radix Bupleurum, add water to distill and extract once for 3 hours to obtain volatile oil and water decoction, add water to extract the remaining medicinal dregs once for 1 hour, and combine with the water decoction obtained from the initial distillation , properly concentrated to a relative density of 1.10 at 50°C, let cool, add ethanol to precipitate until the alcohol content reaches 50%, let it stand, take the supernatant, concentrate and recover the ethanol to obtain a concentrated solution (1), and set aside; take pinellia and ginger , add 50% ethanol for percolation, concentrate the percolation solution to obtain a concentrated solution (2), set aside, take Codonopsis pilosula, jujube and licorice, add water to extract 3 times, each time for 1 hour, combine the extracts and concentrate to relative density at 50°C 1.18, add ethanol to precipitate until the alcohol content reaches 60%, let it stand, take the supernatant and concentrate and recycle the ethanol to obtain a concentrated solution (3), and set aside; take Scutellaria baicalensis, add 10 times the amount of water to extract twice, each time for 1 hour, Add dilute hydrochloric acid to the extract to adjust the pH value to 1.0, keep it warm at 60°C, let it stand, filter, adjust the pH value to 4.0 with ethanol and water for the precipitate, and dry it in vacuum to obtain the Scutellaria baicalensis extract; the obtained (1), (2) , (3) the concentrates are combined, and continue to concentrate into a thick paste (4), with a relative density of 1.25 at 70°C;

(c) Add 2.5 times the amount of lactitol: red alginate to the above-mentioned thick paste (4), the extract of Scutellaria baicalensis, and the volatile oil of Bupleurum baicalensis in the auxiliary material of 1:1, mix well, heat the mixture at 65°C to melt, and stir Evenly, stir for 60 minutes, keep warm, drop at a temperature of 60 ° C, dropper diameter is 1.21 ~ 3.5 mm, drop into liquid paraffin at 8 ° C, drain the formed dripping pills and wipe off the cooling liquid, and wait for drying After subpackage, make drop pills, that is to say.

Example 13

(a) Take Bupleurum 36g, Pinellia 162g, Scutellaria baicalensis 162g, Codonopsis 180g, Jujube 171g, Licorice 117g, Ginger 72g, Lactitol, India gum for later use;

(b) Take Bupleurum bupleuri, add water to distill and extract 4 times, each extraction time is 3 hours, get volatile oil and water decoction, add water to extract the remaining medicinal residues 2 times, each time 1 hour, and decoct with water obtained from the initial distillation The liquids were combined, properly concentrated to a relative density of 1.20 at 50°C, allowed to cool, added ethanol to precipitate until the alcohol content reached 70%, left to stand, and the supernatant was concentrated to recover ethanol to obtain a concentrated solution (1), which was set aside; and ginger, add 70% ethanol for percolation, concentrate the percolation liquid to obtain concentrated solution (2), set aside, take Codonopsis pilosula, jujube and licorice, add water to extract 3 times, each time for 1 hour, combine the extracts and concentrate to 50 °C The relative density is 1.18, add ethanol to precipitate until the alcohol content reaches 60%, let it stand, take the supernatant and concentrate and recover the ethanol to obtain a concentrated solution (3), and set aside; take Scutellaria baicalensis, add 10 times the amount of water to extract twice, each time 1 Hours, add dilute hydrochloric acid to the extract to adjust the pH value to 1.8, keep it warm at 80°C, let it stand, filter, adjust the pH value to 5.5 with ethanol and water for the precipitate, and dry it in vacuum to obtain the Scutellaria baicalensis extract; the obtained (1), ( 2), (3) the concentrates are combined, and continue to concentrate to form a thick paste (4), with a relative density of 1.28 at 70°C;

(c) Add 4.5 times the amount of lactitol: Indian gum weight ratio of 1:0.5 to the above-mentioned thick paste (4), scutellaria baicalensis extract, Bupleurum volatile oil, add to the auxiliary material, mix well, and heat the mixture at 75 ° C Melting, stirring evenly, stirring time is 125 minutes, heat preservation, dripping at 66 °C, dropper diameter is 1.9 mm, drop into vegetable oil at 10 °C, drain the formed dripping pills and wipe off the cooling liquid, wait After drying, subpackage and make drop pills.

Example 14

(a) Take Bupleurum 33.3g, Pinellia 166.7g, Scutellaria baicalensis 166.7g, Codonopsis 166.7g, Jujube 166.7g, Licorice 111.1g, Ginger 88.9g, xylitol, and tragacanth gum for later use;

(b) Take Bupleurum bupleuri, add water to distill and extract 3 times, each extraction time is 3 hours, get volatile oil and water decoction, add water to extract the remaining medicinal residues 2 times, each time 0.5 hours, and decoct with water obtained from the initial distillation The liquids were combined, properly concentrated to a relative density of 1.20 at 50°C, allowed to cool, added ethanol to precipitate until the alcohol content reached 70%, left to stand, and the supernatant was concentrated to recover ethanol to obtain a concentrated solution (1), which was set aside; and ginger, add 70% ethanol for percolation, concentrate the percolation liquid to obtain concentrated solution (2), set aside, take Codonopsis pilosula, jujube and licorice, add water to extract 3 times, each time for 1 hour, combine the extracts and concentrate to 50 °C The relative density is 1.19, add ethanol to precipitate until the alcohol content reaches 70%, let it stand, take the supernatant and concentrate and recover the ethanol to obtain a concentrated solution (3), and set aside; take Scutellaria baicalensis, add 10 times the amount of water to extract twice, each time 1 Add dilute hydrochloric acid to the extract to adjust the pH value to 2.0, keep it warm at 90°C, let it stand, filter, adjust the pH value to 5.5 with ethanol and water for the precipitate, and dry it in vacuum to obtain the Scutellaria baicalensis extract;

(c) Add 7 times of amount, xylitol: tragacanth gum to the above-mentioned thick paste (4), the extract of Scutellaria baicalensis and the volatile oil of Bupleurum baicalensis as the adjuvant of 1: 0.1 by weight, fully mix, and the mixture is mixed at 75 Heat and melt at ℃, stir evenly, the stirring time is 100 minutes, keep warm, drip at 45 ℃, the dropper diameter is 3.5 mm, drop into the methyl silicone oil at -10 ~ 5 ℃, and drain the formed drop pills And wipe off the cooling liquid, pack it after drying, and make it into drop pills.

Example 15

(a) Take Bupleurum 33.3g, Pinellia 166.7g, Scutellaria baicalensis 166.7g, Codonopsis 166.7g, Jujube 166.7g, Licorice 111.1g, Ginger 88.9g, xylitol, and starch for later use;

(b) Take Bupleurum bupleuri, add water to distill and extract 3 times, each extraction time is 3 hours, get volatile oil and water decoction, add water to extract the remaining medicinal residues 2 times, each time 0.5 hours, and decoct with water obtained from the initial distillation The liquids were combined, properly concentrated to a relative density of 1.20 at 50°C, allowed to cool, added ethanol to precipitate until the alcohol content reached 70%, left to stand, and the supernatant was concentrated to recover ethanol to obtain a concentrated solution (1), which was set aside; and ginger, add 70% ethanol for percolation, concentrate the percolation solution to obtain a concentrated solution (2), and set aside; take Codonopsis pilosula, jujube and licorice, add water to extract 3 times, each time for 1 hour, and combine the extracts and concentrate to 50 ° C The relative density is 1.19, add ethanol to precipitate until the alcohol content reaches 70%, let it stand, take the supernatant and concentrate and recover the ethanol to obtain a concentrated solution (3), and set aside; take Scutellaria baicalensis, add 10 times the amount of water to extract twice, each time 1 Hours, add dilute hydrochloric acid to the extract to adjust the pH value to 2.0, keep it warm at 90°C, let it stand, filter, adjust the pH value to 5.5 with ethanol and water for the precipitate, and dry it in vacuum to obtain the Scutellaria baicalensis extract; the obtained (1), ( 2), (3) the concentrates are combined, and continue to concentrate to form a thick paste (4), with a relative density of 1.25 at 70°C;

(c) Add 5.5 times of amount, xylitol: starch weight ratio 1:0.25 auxiliary materials to the above-mentioned thick paste (4), Scutellaria baicalensis extract, Bupleurum volatile oil, fully mix, the mixture is heated and melted at 85°C, Stir evenly, the stirring time is 10-30 minutes, keep warm, drip at 85°C, the diameter of the dropper is 1.1-3.5mm, drop in liquid paraffin at 0-5°C, drain and wipe off the formed drop pills The cooling liquid, after being dried, is subpackaged and made into drop pills.

Example 16

(a) Take Bupleurum 33.3g, Pinellia 166.7g, Scutellaria baicalensis 166.7g, Codonopsis 166.7g, Chinese jujube 166.7g, licorice 111.1g, ginger 88.9g, lactitol, and starch for later use;

(b) Take Bupleurum bupleuri, add water to distill and extract 3 times, each extraction time is 3 hours, get volatile oil and water decoction, add water to extract the remaining medicinal residues 2 times, each time 0.5 hours, and decoct with water obtained from the initial distillation The liquids were combined, properly concentrated to a relative density of 1.20 at 50°C, allowed to cool, added ethanol to precipitate until the alcohol content reached 80%, left to stand, and the supernatant was concentrated to recover the ethanol to obtain a concentrated solution (1), which was set aside; and ginger, add 70% ethanol for percolation, concentrate the percolation solution to obtain a concentrated solution (2), and set aside; take Codonopsis pilosula, jujube and licorice, add water to extract 3 times, each time for 1 hour, and combine the extracts and concentrate to 50 ° C The relative density is 1.19, add ethanol to precipitate until the alcohol content reaches 70%, let it stand, take the supernatant and concentrate and recover the ethanol to obtain a concentrated solution (3), and set aside; take Scutellaria baicalensis, add 10 times the amount of water to extract twice, each time 1 Hours, add dilute hydrochloric acid to the extract to adjust the pH value to 1.5, keep it warm at 80°C, let it stand, filter, adjust the pH value to 5.5 with ethanol and water for the precipitate, and dry it in vacuum to obtain the Scutellaria baicalensis extract; the obtained (1), ( 2), (3) the concentrates are combined, and continue to concentrate to form a thick paste (4), with a relative density of 1.25 at 70°C;

(c) Add 8 times the amount of excipients whose lactitol:starch weight ratio is 1:0.6 to the above-mentioned thick paste (4), Scutellaria baicalensis extract, and Bupleurum volatile oil, mix well, and heat the mixture at 85-89°C to melt , stir evenly, the stirring time is 30 minutes, keep warm, drip at 63 °C, the diameter of the dropper is 1.8 mm, drop into the methyl silicone oil at 0 °C, drain the formed drop pills and wipe off the cooling liquid, After drying, subpackage and make drop pills.

Example 17

(a) Take Bupleurum 33.3g, Pinellia 166.7g, Scutellaria baicalensis 166.7g, Codonopsis 166.7g, Chinese jujube 166.7g, licorice 111.1g, ginger 88.9g, xylitol, and gum arabic;

(b) Take Bupleurum bupleuri, add water to distill and extract 3 times, each extraction time is 3 hours, get volatile oil and water decoction, add water to extract the remaining medicinal residues 2 times, each time 0.5 hours, and decoct with water obtained from the initial distillation The liquids were combined, properly concentrated to a relative density of 1.20 at 50°C, allowed to cool, added ethanol to precipitate until the alcohol content reached 70%, left to stand, and the supernatant was concentrated to recover ethanol to obtain a concentrated solution (1), which was set aside; and ginger, add 70% ethanol for percolation, concentrate the percolation solution to obtain a concentrated solution (2), and set aside; take Codonopsis pilosula, jujube and licorice, add water to extract 3 times, each time for 1 hour, and combine the extracts and concentrate to 50 ° C The relative density is 1.15, add ethanol to precipitate until the alcohol content reaches 80%, let it stand, take the supernatant, concentrate and recover the ethanol to obtain a concentrated solution (3), and set aside; take Scutellaria baicalensis, add 10 times the amount of water to extract 2 times, each time 1 Hours, add dilute hydrochloric acid to the extract to adjust the pH value to 2.0, keep it warm at 90°C, let it stand, filter, adjust the pH value to 5.5 with ethanol and water for the precipitate, and dry it in vacuum to obtain the Scutellaria baicalensis extract; the obtained (1), ( 2), (3) the concentrates are combined and continue to concentrate into a thick paste (4);

(c) Add 3 times the amount of xylitol: the weight ratio of gum arabic is 1: 0.4 to the above-mentioned thick paste (4), Scutellaria baicalensis extract, Bupleurum volatile oil, fully mix, and the mixture is heated at 95 ° C. Heat and melt, stir evenly, stir for 15 minutes, keep warm, drip at 90°C, dropper diameter is 1.1-2.5 mm, drop into methyl silicone oil at 0-5°C, and drain the formed drop pills And wipe off the cooling liquid, pack it after drying, and make it into drop pills.

Claims (9)

1. A Xiaochaihutang dripping pill, characterized in that Bupleurum 1～5%, Pinellia 15～20%, Scutellaria baicalensis 15～20%, Codonopsis 15～20%, Jujube 15～20%, Radix Glycyrrhizae 10～20%. 15%, ginger 8-13%, the weight ratio of the extract obtained by extracting the above-mentioned medicinal materials to the auxiliary material is 0.1:1-1:1, wherein the auxiliary material is composed of a filler and a plasticizing matrix, and the filler is selected from Natural excipients from one or more of the following plant sources: erythritol, sorbitol, arabitol, trehalose, xylitol, isomalt, lactitol, maltose; said plasticizing matrix is selected from One or more of the following natural excipients of plant origin: starch and its derivatives, cellulose and its derivatives, acacia, chitin, ghatta, dugal gum, tragacanth, pectin, xanthan glue, alginic acid, dextrin, cyclodextrin, agar, lactose; the starch and its derivatives are pregelatinized starch, hydroxypropyl starch, carboxymethyl starch, and the cellulose and its derivatives are methyl Cellulose, Sodium Carboxymethyl Cellulose, Hydroxypropyl Methyl Cellulose. 2. A kind of Xiao Chai Hu Tang dripping pill as claimed in claim 1, characterized in that the content of medicinal materials is 3.7% of Bupleurum, 18.5% of Pinellia, 18.5% of Scutellaria, 18.5% of Codonopsis, 18.5% of Jujube, and 12.3 g of Radix Glycyrrhizae. %, ginger 10%, the weight ratio of the extract obtained from the extraction of the above-mentioned medicinal materials to the auxiliary materials is 0.1:1-0.6:1, and the filler auxiliary materials are selected from the following one or more natural auxiliary materials derived from plants: Sorbitol, xylitol, lactitol, maltose, and their crystalline water compounds; wherein the plasticizing matrix is selected from one or more of the following plant-derived natural excipients: pregelatinized starch, carboxymethyl starch, Methylcellulose, hydroxypropylmethylcellulose, gum arabic, alginic acid, dextrin, cyclodextrin, agar, lactose. 3. A kind of Xiaochaihutang dripping pill as claimed in claim 1, characterized in that the weight ratio of the extract obtained through extraction of the above-mentioned medicinal material to the auxiliary material is 0.2～1:0.4:1, wherein the filler auxiliary material is selected from One or more of the following natural excipients derived from plants: xylitol, lactitol; wherein the plasticizing matrix is selected from one or more of the following natural excipients derived from plants: starch, gum arabic. 4. A Xiaochaihutang dripping pill as claimed in claim 3, characterized in that the auxiliary materials are xylitol and starch, and the weight ratio of xylitol and starch is 1:0.2-1:0.3. 5. A Xiaochaihutang dripping pill as claimed in claim 3, characterized in that the auxiliary materials are lactitol and starch, and the weight ratio of lactitol and starch is 1:0.2-1:0.3. 6. A Xiaochaihutang dripping pill as claimed in claim 3, characterized in that the auxiliary materials are xylitol and gum arabic, and the weight ratio of xylitol and gum arabic is 1:0.2-1:0.4. 7. A method for preparing Xiaochaihutang dripping pills according to claim 1, 2 or 3, characterized in that the method comprises the following steps: (a) Take Bupleurum 1-5%, Pinellia 15-20%, Scutellaria baicalensis 15-20%, Codonopsis 15-20%, Jujube 15-20%, Licorice 10-15%, Ginger 8-13% for later use ; (b) Take Radix Bupleuri, distill and extract with water to obtain volatile oil and water decoction, add water to extract the remaining medicinal residues, combine with the water decoction obtained from the initial distillation, properly concentrate, let cool, add ethanol for precipitation, and let stand, Concentrate the supernatant and recover ethanol to obtain a concentrated solution (1) for later use; take pinellia and ginger, add ethanol for percolation, and concentrate the percolation solution to obtain a concentrated solution (2), for later use; take Codonopsis pilosula, jujube and licorice, and extract with water , add ethanol to precipitate, let stand, take the supernatant and concentrate and reclaim ethanol to obtain a concentrated solution (3), and set aside; take Scutellaria baicalensis, add water to extract, add dilute hydrochloric acid to the extract to adjust the pH value, keep warm, stand still, filter, and use ethanol for precipitation and water to adjust the pH value, and vacuum-dry to obtain the Scutellaria baicalensis extract; combine the obtained concentrated solutions of (1), (2), and (3), and continue to concentrate to form a thick paste (4); (c) Add the above-mentioned thick paste (4), Scutellaria baicalensis extract, Bupleurum volatile oil to an appropriate amount of auxiliary materials, mix well, heat and melt the mixture at 45-115°C, stir evenly, and stir for 1-120 minutes, keep warm, and keep warm at 45°C Dropping at a temperature of ~95°C, the diameter of the dropper is 1.0-4.0 mm, drop into liquid paraffin, methyl silicone oil or vegetable oil at -20-25°C, and make drop pills. 8. A method for preparing Xiaochaihutang dripping pills as claimed in claim 7, characterized in that the method comprises the following steps: (a) Take the following medicinal materials according to the prescription: Bupleurum 3.7%, Pinellia 18.5%, Scutellaria baicalensis 18.5%, Codonopsis 18.5%, Jujube 18.5%, licorice 12.3%, ginger 10% for later use; (b) Take Bupleurum bupleuri, add water to distill and extract 3 times, each extraction time is 3 hours, get volatile oil and water decoction, add water to extract the remaining medicinal residues 2 times, each time 1 hour, and decoct with water obtained from the initial distillation The liquids were combined, properly concentrated to a relative density of 1.20 at 50°C, allowed to cool, added ethanol to precipitate until the alcohol content reached 70%, left to stand, and the supernatant was concentrated to recover ethanol to obtain a concentrated solution (1), which was set aside; and ginger, add 70% ethanol for percolation, concentrate the percolation liquid to obtain concentrated solution (2), set aside, take Codonopsis pilosula, jujube and licorice, add water to extract 3 times, each time for 1 hour, combine the extracts and concentrate to 50 °C The relative density is 1.18, add ethanol to precipitate until the alcohol content reaches 60%, let it stand, take the supernatant and concentrate and recover the ethanol to obtain a concentrated solution (3), and set aside; take Scutellaria baicalensis, add 10 times the amount of water to extract twice, each time 1 Hours, add dilute hydrochloric acid to the extract to adjust the pH value to 1.8, keep it warm at 80°C, let it stand, filter, adjust the pH value to 5.5 with ethanol and water for the precipitate, and dry it in vacuum to obtain the Scutellaria baicalensis extract; the obtained (1), ( 2), (3) the concentrates are combined and continue to concentrate into a thick paste (4); (c) Add the above-mentioned thick paste (4), Scutellaria baicalensis extract, Bupleurum volatile oil to an appropriate amount of auxiliary materials, mix well, heat and melt the mixture at 60-85°C, stir evenly, the stirring time is 10-30 minutes, keep warm, and keep warm at 60°C Dropping at a temperature of ~85°C, the diameter of the dropper is 1.1~3.5mm, drop into liquid paraffin and methyl silicone oil at 0~18°C, drain the formed drop pills and wipe off the cooling liquid, and pack after drying , made into dripping pills, that is to say. 9. A method for preparing Xiaochaihutang dripping pills as claimed in claim 7, characterized in that the method comprises the following steps: (a) Take the following medicinal materials according to the prescription: Bupleurum 3.7%, Pinellia 18.5%, Scutellaria baicalensis 18.5%, Codonopsis 18.5%, Jujube 18.5%, licorice 12.3%, ginger 10% for later use; (b) Take Bupleurum bupleuri, add water to distill and extract 3 times, each extraction time is 3 hours, get volatile oil and water decoction, add water to extract the remaining medicinal residues 2 times, each time 1 hour, and decoct with water obtained from the initial distillation The liquids were combined, properly concentrated to a relative density of 1.20 at 50°C, allowed to cool, added ethanol to precipitate until the alcohol content reached 70%, left to stand, and the supernatant was concentrated to recover ethanol to obtain a concentrated solution (1), which was set aside; and ginger, add 70% ethanol for percolation, concentrate the percolation liquid to obtain concentrated solution (2), set aside, take Codonopsis pilosula, jujube and licorice, add water to extract 3 times, each time for 1 hour, combine the extracts and concentrate to 50 °C The relative density is 1.18, add ethanol to precipitate until the alcohol content reaches 60%, let it stand, take the supernatant and concentrate and recover the ethanol to obtain a concentrated solution (3), and set aside; take Scutellaria baicalensis, add 10 times the amount of water to extract twice, each time 1 Hours, add dilute hydrochloric acid to the extract to adjust the pH value to 1.8, keep it warm at 80°C, let it stand, filter, adjust the pH value to 5.5 with ethanol and water for the precipitate, and dry it in vacuum to obtain the Scutellaria baicalensis extract; the obtained (1), ( 2), (3) the concentrates are combined and continue to concentrate into a thick paste (4); (c) Add the above-mentioned thick paste (4), scutellaria baicalensis extract, Bupleurum volatile oil to an appropriate amount of auxiliary materials, mix well, heat and melt the mixture at 64°C, stir evenly, stir for 10-30 minutes, keep warm, and heat at 64°C Dropping system, the diameter of the dropper is 1.2-2.5 mm, drop into the methyl silicone oil at 0 ℃, drain the formed droplet and wipe off the cooling liquid, divide it after drying, and make the droplet.