CN100450504C - Medication for treating pharyngitis - Google Patents
Medication for treating pharyngitis Download PDFInfo
- Publication number
- CN100450504C CN100450504C CNB2003101073020A CN200310107302A CN100450504C CN 100450504 C CN100450504 C CN 100450504C CN B2003101073020 A CNB2003101073020 A CN B2003101073020A CN 200310107302 A CN200310107302 A CN 200310107302A CN 100450504 C CN100450504 C CN 100450504C
- Authority
- CN
- China
- Prior art keywords
- add
- adjuvant
- ethanol
- water
- adds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000003814 drug Substances 0.000 title claims abstract description 118
- 201000007100 Pharyngitis Diseases 0.000 title claims abstract description 30
- 229940079593 drug Drugs 0.000 title claims description 42
- 239000006187 pill Substances 0.000 claims abstract description 113
- 238000002360 preparation method Methods 0.000 claims abstract description 36
- 239000000463 material Substances 0.000 claims abstract description 19
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 394
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 115
- 239000002671 adjuvant Substances 0.000 claims description 114
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 108
- 239000000203 mixture Substances 0.000 claims description 93
- 239000006228 supernatant Substances 0.000 claims description 81
- 239000007788 liquid Substances 0.000 claims description 80
- QQILFGKZUJYXGS-UHFFFAOYSA-N Indigo dye Chemical compound C1=CC=C2C(=O)C(C3=C(C4=CC=CC=C4N3)O)=NC2=C1 QQILFGKZUJYXGS-UHFFFAOYSA-N 0.000 claims description 78
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 72
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 71
- 239000000811 xylitol Substances 0.000 claims description 71
- 235000010447 xylitol Nutrition 0.000 claims description 71
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 71
- 229960002675 xylitol Drugs 0.000 claims description 71
- 239000000758 substrate Substances 0.000 claims description 61
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims description 60
- 239000006071 cream Substances 0.000 claims description 55
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims description 54
- 238000001914 filtration Methods 0.000 claims description 54
- NOOLISFMXDJSKH-UHFFFAOYSA-N p-menthan-3-ol Chemical compound CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims description 51
- 229920002472 Starch Polymers 0.000 claims description 50
- 239000008107 starch Substances 0.000 claims description 50
- 235000019698 starch Nutrition 0.000 claims description 50
- 238000002156 mixing Methods 0.000 claims description 38
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 35
- 239000008101 lactose Substances 0.000 claims description 34
- 238000010438 heat treatment Methods 0.000 claims description 32
- 238000002844 melting Methods 0.000 claims description 32
- 230000008018 melting Effects 0.000 claims description 32
- 238000003756 stirring Methods 0.000 claims description 32
- 235000010489 acacia gum Nutrition 0.000 claims description 31
- 239000001785 acacia senegal l. willd gum Substances 0.000 claims description 31
- 238000012546 transfer Methods 0.000 claims description 29
- 244000303040 Glycyrrhiza glabra Species 0.000 claims description 27
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims description 27
- 244000071378 Viburnum opulus Species 0.000 claims description 27
- 235000019013 Viburnum opulus Nutrition 0.000 claims description 27
- 229910021529 ammonia Inorganic materials 0.000 claims description 27
- 238000009835 boiling Methods 0.000 claims description 27
- 239000000706 filtrate Substances 0.000 claims description 27
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims description 27
- 238000009413 insulation Methods 0.000 claims description 27
- 235000011477 liquorice Nutrition 0.000 claims description 27
- 230000007935 neutral effect Effects 0.000 claims description 27
- 239000002244 precipitate Substances 0.000 claims description 27
- 238000012545 processing Methods 0.000 claims description 27
- 238000007670 refining Methods 0.000 claims description 27
- 238000004062 sedimentation Methods 0.000 claims description 27
- 238000002791 soaking Methods 0.000 claims description 27
- 238000000034 method Methods 0.000 claims description 26
- 229920002545 silicone oil Polymers 0.000 claims description 25
- 241000196324 Embryophyta Species 0.000 claims description 24
- 239000002826 coolant Substances 0.000 claims description 22
- 238000012856 packing Methods 0.000 claims description 20
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 13
- -1 hydroxypropyl Chemical group 0.000 claims description 13
- 239000000600 sorbitol Substances 0.000 claims description 13
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 12
- 239000000945 filler Substances 0.000 claims description 12
- 229940057995 liquid paraffin Drugs 0.000 claims description 11
- 235000000177 Indigofera tinctoria Nutrition 0.000 claims description 9
- 241001597008 Nomeidae Species 0.000 claims description 9
- 241000001522 Terminalia chebula Species 0.000 claims description 9
- 229940097275 indigo Drugs 0.000 claims description 9
- COHYTHOBJLSHDF-UHFFFAOYSA-N indigo powder Natural products N1C2=CC=CC=C2C(=O)C1=C1C(=O)C2=CC=CC=C2N1 COHYTHOBJLSHDF-UHFFFAOYSA-N 0.000 claims description 9
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims description 8
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 8
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims description 8
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims description 8
- 229920000858 Cyclodextrin Polymers 0.000 claims description 7
- 150000001875 compounds Chemical class 0.000 claims description 7
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims description 7
- 229940032147 starch Drugs 0.000 claims description 7
- 239000004386 Erythritol Substances 0.000 claims description 6
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 claims description 6
- 229920000881 Modified starch Polymers 0.000 claims description 6
- 235000010418 carrageenan Nutrition 0.000 claims description 6
- 229920001525 carrageenan Polymers 0.000 claims description 6
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 claims description 6
- 235000019414 erythritol Nutrition 0.000 claims description 6
- 229940009714 erythritol Drugs 0.000 claims description 6
- 229920000609 methyl cellulose Polymers 0.000 claims description 6
- 239000001923 methylcellulose Substances 0.000 claims description 6
- 235000010981 methylcellulose Nutrition 0.000 claims description 6
- 229920001285 xanthan gum Polymers 0.000 claims description 6
- 235000010493 xanthan gum Nutrition 0.000 claims description 6
- 239000000230 xanthan gum Substances 0.000 claims description 6
- 229940082509 xanthan gum Drugs 0.000 claims description 6
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 claims description 5
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 claims description 5
- 239000000679 carrageenan Substances 0.000 claims description 5
- 229940113118 carrageenan Drugs 0.000 claims description 5
- 238000002425 crystallisation Methods 0.000 claims description 5
- 230000008025 crystallization Effects 0.000 claims description 5
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims description 5
- 229920002101 Chitin Polymers 0.000 claims description 4
- 244000286663 Ficus elastica Species 0.000 claims description 4
- 244000275012 Sesbania cannabina Species 0.000 claims description 4
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 claims description 4
- 235000010980 cellulose Nutrition 0.000 claims description 4
- 229920002678 cellulose Polymers 0.000 claims description 4
- 239000001913 cellulose Substances 0.000 claims description 4
- 235000015112 vegetable and seed oil Nutrition 0.000 claims description 4
- 239000008158 vegetable oil Substances 0.000 claims description 4
- 229960001375 lactose Drugs 0.000 claims description 3
- 239000004014 plasticizer Substances 0.000 claims 3
- 229960002920 sorbitol Drugs 0.000 claims 1
- 229940074410 trehalose Drugs 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 20
- 231100000331 toxic Toxicity 0.000 abstract description 7
- 230000002588 toxic effect Effects 0.000 abstract description 7
- 235000013373 food additive Nutrition 0.000 abstract description 3
- 239000002778 food additive Substances 0.000 abstract description 3
- 235000019659 mouth feeling Nutrition 0.000 abstract 1
- 229940023488 pill Drugs 0.000 description 102
- 239000002202 Polyethylene glycol Substances 0.000 description 14
- 229920001223 polyethylene glycol Polymers 0.000 description 14
- 238000012360 testing method Methods 0.000 description 14
- 238000009472 formulation Methods 0.000 description 13
- 238000004519 manufacturing process Methods 0.000 description 12
- 210000003800 pharynx Anatomy 0.000 description 10
- 238000009833 condensation Methods 0.000 description 9
- 230000005494 condensation Effects 0.000 description 9
- 210000000214 mouth Anatomy 0.000 description 9
- 201000010099 disease Diseases 0.000 description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 8
- 238000011160 research Methods 0.000 description 8
- 239000003795 chemical substances by application Substances 0.000 description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- 239000000084 colloidal system Substances 0.000 description 6
- 239000000843 powder Substances 0.000 description 6
- 230000008569 process Effects 0.000 description 6
- 150000005846 sugar alcohols Polymers 0.000 description 6
- 229920001353 Dextrin Polymers 0.000 description 5
- 239000004375 Dextrin Substances 0.000 description 5
- 208000016150 acute pharyngitis Diseases 0.000 description 5
- 230000008859 change Effects 0.000 description 5
- 235000019425 dextrin Nutrition 0.000 description 5
- 238000005516 engineering process Methods 0.000 description 5
- 229920000591 gum Polymers 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 4
- 235000010443 alginic acid Nutrition 0.000 description 4
- 229920000615 alginic acid Polymers 0.000 description 4
- 239000000783 alginic acid Substances 0.000 description 4
- 229960001126 alginic acid Drugs 0.000 description 4
- 150000004781 alginic acids Chemical class 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- 229940046011 buccal tablet Drugs 0.000 description 4
- 239000006189 buccal tablet Substances 0.000 description 4
- 239000001768 carboxy methyl cellulose Substances 0.000 description 4
- 230000000857 drug effect Effects 0.000 description 4
- 230000003203 everyday effect Effects 0.000 description 4
- 238000000605 extraction Methods 0.000 description 4
- 235000013305 food Nutrition 0.000 description 4
- 230000004927 fusion Effects 0.000 description 4
- 239000004615 ingredient Substances 0.000 description 4
- 239000006225 natural substrate Substances 0.000 description 4
- 238000012216 screening Methods 0.000 description 4
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 4
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- SERLAGPUMNYUCK-DCUALPFSSA-N 1-O-alpha-D-glucopyranosyl-D-mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O SERLAGPUMNYUCK-DCUALPFSSA-N 0.000 description 3
- 229920001817 Agar Polymers 0.000 description 3
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 3
- 229930195725 Mannitol Natural products 0.000 description 3
- 239000008272 agar Substances 0.000 description 3
- 235000010419 agar Nutrition 0.000 description 3
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 description 3
- 230000018109 developmental process Effects 0.000 description 3
- 235000013402 health food Nutrition 0.000 description 3
- 239000000905 isomalt Substances 0.000 description 3
- 235000010439 isomalt Nutrition 0.000 description 3
- HPIGCVXMBGOWTF-UHFFFAOYSA-N isomaltol Natural products CC(=O)C=1OC=CC=1O HPIGCVXMBGOWTF-UHFFFAOYSA-N 0.000 description 3
- 239000000594 mannitol Substances 0.000 description 3
- 235000010355 mannitol Nutrition 0.000 description 3
- 238000000465 moulding Methods 0.000 description 3
- 231100000957 no side effect Toxicity 0.000 description 3
- 229920001277 pectin Polymers 0.000 description 3
- 239000001814 pectin Substances 0.000 description 3
- 229920001282 polysaccharide Polymers 0.000 description 3
- 239000005017 polysaccharide Substances 0.000 description 3
- 150000004804 polysaccharides Chemical class 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- 230000035943 smell Effects 0.000 description 3
- 235000002639 sodium chloride Nutrition 0.000 description 3
- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 description 2
- 206010011224 Cough Diseases 0.000 description 2
- SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 description 2
- 231100000111 LD50 Toxicity 0.000 description 2
- 235000004298 Tamarindus indica Nutrition 0.000 description 2
- 240000004584 Tamarindus indica Species 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- 230000002159 abnormal effect Effects 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- PYMYPHUHKUWMLA-LMVFSUKVSA-N aldehydo-D-ribose Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 description 2
- 239000003513 alkali Substances 0.000 description 2
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 description 2
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 description 2
- 230000001684 chronic effect Effects 0.000 description 2
- 235000015165 citric acid Nutrition 0.000 description 2
- 239000002131 composite material Substances 0.000 description 2
- 230000002950 deficient Effects 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000019634 flavors Nutrition 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 235000008216 herbs Nutrition 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 231100000053 low toxicity Toxicity 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 235000010987 pectin Nutrition 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 208000037920 primary disease Diseases 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 230000003578 releasing effect Effects 0.000 description 2
- 210000003296 saliva Anatomy 0.000 description 2
- 230000035807 sensation Effects 0.000 description 2
- 235000019615 sensations Nutrition 0.000 description 2
- 239000004334 sorbic acid Substances 0.000 description 2
- 235000010199 sorbic acid Nutrition 0.000 description 2
- 229940075582 sorbic acid Drugs 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 2
- 235000000346 sugar Nutrition 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 230000000699 topical effect Effects 0.000 description 2
- 239000003053 toxin Substances 0.000 description 2
- 231100000765 toxin Toxicity 0.000 description 2
- PVNIQBQSYATKKL-UHFFFAOYSA-N tripalmitin Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCC PVNIQBQSYATKKL-UHFFFAOYSA-N 0.000 description 2
- LUEWUZLMQUOBSB-FSKGGBMCSA-N (2s,3s,4s,5s,6r)-2-[(2r,3s,4r,5r,6s)-6-[(2r,3s,4r,5s,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5s,6r)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@@H](O[C@@H]2[C@H](O[C@@H](OC3[C@H](O[C@@H](O)[C@@H](O)[C@H]3O)CO)[C@@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O LUEWUZLMQUOBSB-FSKGGBMCSA-N 0.000 description 1
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 1
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 229920000178 Acrylic resin Polymers 0.000 description 1
- 239000004925 Acrylic resin Substances 0.000 description 1
- 229920000936 Agarose Polymers 0.000 description 1
- 244000247812 Amorphophallus rivieri Species 0.000 description 1
- 235000001206 Amorphophallus rivieri Nutrition 0.000 description 1
- 206010002953 Aphonia Diseases 0.000 description 1
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 1
- 244000241235 Citrullus lanatus Species 0.000 description 1
- 235000012828 Citrullus lanatus var citroides Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-QWWZWVQMSA-N D-arabinitol Chemical compound OC[C@@H](O)C(O)[C@H](O)CO HEBKCHPVOIAQTA-QWWZWVQMSA-N 0.000 description 1
- 208000012239 Developmental disease Diseases 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- OJIYIVCMRYCWSE-UHFFFAOYSA-M Domiphen bromide Chemical compound [Br-].CCCCCCCCCCCC[N+](C)(C)CCOC1=CC=CC=C1 OJIYIVCMRYCWSE-UHFFFAOYSA-M 0.000 description 1
- 206010013952 Dysphonia Diseases 0.000 description 1
- 241001411320 Eriogonum inflatum Species 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- 206010017577 Gait disturbance Diseases 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 206010060891 General symptom Diseases 0.000 description 1
- 229920002581 Glucomannan Polymers 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 1
- 229920002527 Glycogen Polymers 0.000 description 1
- 229920002907 Guar gum Polymers 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 208000010473 Hoarseness Diseases 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
- 229920001479 Hydroxyethyl methyl cellulose Polymers 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 229920002752 Konjac Polymers 0.000 description 1
- 229920000161 Locust bean gum Polymers 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 1
- 239000004368 Modified starch Substances 0.000 description 1
- 102000016943 Muramidase Human genes 0.000 description 1
- 108010014251 Muramidase Proteins 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- MUPFEKGTMRGPLJ-RMMQSMQOSA-N Raffinose Natural products O(C[C@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](O[C@@]2(CO)[C@H](O)[C@@H](O)[C@@H](CO)O2)O1)[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 MUPFEKGTMRGPLJ-RMMQSMQOSA-N 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical class [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- MUPFEKGTMRGPLJ-UHFFFAOYSA-N UNPD196149 Natural products OC1C(O)C(CO)OC1(CO)OC1C(O)C(O)C(O)C(COC2C(C(O)C(O)C(CO)O2)O)O1 MUPFEKGTMRGPLJ-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 150000005215 alkyl ethers Chemical class 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- 230000003444 anaesthetic effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- PEEKVIHQOHJITP-UHFFFAOYSA-N boric acid;propane-1,2,3-triol Chemical compound OB(O)O.OCC(O)CO PEEKVIHQOHJITP-UHFFFAOYSA-N 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 235000013877 carbamide Nutrition 0.000 description 1
- 229960001631 carbomer Drugs 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 208000027744 congestion Diseases 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 208000029078 coronary artery disease Diseases 0.000 description 1
- 229960000265 cromoglicic acid Drugs 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 206010061428 decreased appetite Diseases 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- VLARUOGDXDTHEH-UHFFFAOYSA-L disodium cromoglycate Chemical compound [Na+].[Na+].O1C(C([O-])=O)=CC(=O)C2=C1C=CC=C2OCC(O)COC1=CC=CC2=C1C(=O)C=C(C([O-])=O)O2 VLARUOGDXDTHEH-UHFFFAOYSA-L 0.000 description 1
- 229960001859 domiphen bromide Drugs 0.000 description 1
- 239000008298 dragée Substances 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 210000000887 face Anatomy 0.000 description 1
- 238000007667 floating Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 229940046240 glucomannan Drugs 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 235000001727 glucose Nutrition 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 150000002333 glycines Chemical class 0.000 description 1
- 229940096919 glycogen Drugs 0.000 description 1
- 235000010417 guar gum Nutrition 0.000 description 1
- 239000000665 guar gum Substances 0.000 description 1
- 229960002154 guar gum Drugs 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 1
- 239000001341 hydroxy propyl starch Substances 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 229940071826 hydroxyethyl cellulose Drugs 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
- 235000013828 hydroxypropyl starch Nutrition 0.000 description 1
- 208000013403 hyperactivity Diseases 0.000 description 1
- 210000003026 hypopharynx Anatomy 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 239000013067 intermediate product Substances 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 235000015110 jellies Nutrition 0.000 description 1
- 239000008274 jelly Substances 0.000 description 1
- 235000010485 konjac Nutrition 0.000 description 1
- 239000000252 konjac Substances 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 235000010420 locust bean gum Nutrition 0.000 description 1
- 239000000711 locust bean gum Substances 0.000 description 1
- 239000004325 lysozyme Substances 0.000 description 1
- 235000010335 lysozyme Nutrition 0.000 description 1
- 229960000274 lysozyme Drugs 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 238000007726 management method Methods 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 208000030159 metabolic disease Diseases 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 235000019426 modified starch Nutrition 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 238000002663 nebulization Methods 0.000 description 1
- IAIWVQXQOWNYOU-FPYGCLRLSA-N nitrofural Chemical compound NC(=O)N\N=C\C1=CC=C([N+]([O-])=O)O1 IAIWVQXQOWNYOU-FPYGCLRLSA-N 0.000 description 1
- 229960001907 nitrofurazone Drugs 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 229960000292 pectin Drugs 0.000 description 1
- 238000005325 percolation Methods 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 230000007096 poisonous effect Effects 0.000 description 1
- 229960000502 poloxamer Drugs 0.000 description 1
- 229920001983 poloxamer Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229910052573 porcelain Inorganic materials 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 235000021251 pulses Nutrition 0.000 description 1
- MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 238000007560 sedimentation technique Methods 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- RYYKJJJTJZKILX-UHFFFAOYSA-M sodium octadecanoate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC([O-])=O RYYKJJJTJZKILX-UHFFFAOYSA-M 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000001384 succinic acid Substances 0.000 description 1
- 239000007940 sugar coated tablet Substances 0.000 description 1
- JNMRHUJNCSQMMB-UHFFFAOYSA-N sulfathiazole Chemical compound C1=CC(N)=CC=C1S(=O)(=O)NC1=NC=CS1 JNMRHUJNCSQMMB-UHFFFAOYSA-N 0.000 description 1
- 229960001544 sulfathiazole Drugs 0.000 description 1
- 230000009747 swallowing Effects 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000026676 system process Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000035922 thirst Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 229960001947 tripalmitin Drugs 0.000 description 1
- 238000003809 water extraction Methods 0.000 description 1
Abstract
The present invention provides medicine for treating pharyngitis. The present invention overcomes the disadvantages that the supplementary materials used by drop pills presently have low natural degree, the present frequently-used chemosynthesis supplementary materials can not be found in the food additive catalogues of certain nations, and the drop pills have bad mouth feeling. The present invention is a medicinal preparation with high natural degree, strong security and very little toxic or side effect.
Description
Technical field
The present invention relates to a kind of medicine that is used for the treatment of pharyngitis, specifically it is to be the pharmaceutical preparation that is used for the treatment of pharyngitis that raw material is made with the Chinese herbal medicine.
Background technology
Pharyngitis is the disease of respiratory tract, is a kind of commonly encountered diseases.Modern medicine is divided into acute and chronic two kinds to primary disease, acute pharyngitis show effect repeatedly or since environment in some factor long-time stimulus can transfer chronic pharyngitis to.Chinese medicine thinks that primary disease is many by wind-heat evil toxin invasion and attack bottleneck throat, or the stomach mansion have hot and suffocating, the upper punch throat, or hyperactivity of deficient fire causes, and common sympton is that the acute pharyngitis onset is more anxious, the first pharyngeal drying of time-out, scorching hot, then pharyngalgia occurs, often more obvious than when feed when swallowing saliva, saliva is increased, General Symptoms is generally lighter, and heating, headache, inappetence and extremities aching pain etc. can be arranged.Transfer the visible pharyngeal chronic congestion that is after the chronic pharyngitis to, pharyngeal have various uncomfortable sensations, as itch, scorching hot, dry, foreign body sensation etc.The secretions thickness often invests the pharynx rear wall.Hoarseness, Chang Yichen rise attaches most importance to, the thick even aphonia of sound.
Therapeutic Method commonly used clinically at present is a topical therapeutic, and local method of treatment comprises (1) rinsing the mouth method: medicine commonly used has Dobell's solution, furacilin solution, hibitane collutory etc., and the rinsing the mouth method can only act on before the isthmus faucium, and pharynx rear wall and sidewall difficulty touch.(2) buccal tablet: be the most frequently used method, medicine commonly used has domiphen bromide buccal tablet, tabellae iodi gurgitis, tabellae menthae gurgitis, lysozyme sheet, pills for throat disease, LIUSHEN WAN, watermelon crystal buccal tablet, Herba Pileae Scriptae Tabellae etc., though the ingredient of this type of buccal tablet can directly act on oral cavity, isthmus faucium, pharynx wall and laryngopharynx portion mucosa, but drug releasing rate is slower, and onset is slower.(3) coating method: medicine commonly used has glycerinum iodi compositum, boric acid glycerin, compound recipe Herba Menthae wet goods, and this type of easily is dropped into throat, causes the irritative cough.(4) insufflation therapy: common drug such as sodium cromoglicate, inferior carbonic acid sulfathiazole powder, and the Chinese medicine SHANGLIAOHOUFENG SAN etc., this type of medicine mostly is powder, and easily causing chokes coughs.(5) nebulization: be the better administering mode that gets, but medicine commonly used at present mostly is topical anesthetic cream, can not fundamentally solve pharyngitis; (6) aerosol rebreathing method or smoked gas Fa Changyin high temperature destroy composition in the medicinal liquid, or are difficult to promote because of the ultrasonic atomizatio inhaler is more expensive.
The synthetic chemical substance that modern medicine is commonly used has spreaded all over each corner of human lives, chemical synthetic drug becomes the main flow of medicine, yet, appearance along with multiple difficult serious symptom miscellaneous diseases, western medical treatment presents imperfect, the human lives and the healthy reality and the up-to-date successes achieved in research have all proposed query to this situation, particularly along with the continuous appearance of chemical drugs toxic and side effects, the change of spectrum of disease and conversion of medical, make modern medicine be subjected to unprecedented challenge, and people also place hope in the application and development of traditional medicine on gradually.Advocate back to nature, pay attention to plant amedica use, hanker after traditional remedies, the trend of advocating natural drug forms, making full use of natural materials is human best selections.
At present, in the world, natural drug all has certain market, along with people increasing and the aging of population to the health requirements level of understanding, sub-health stateization, people thirst for back to nature more, the problem of utilize the high Drug therapy of pure natural degree, preventing some chemical synthetic drugs cann't be solved, so the background that exceeds its original traditional national culture has been expanded in the application of natural plant.From natural drug, seek the little and inexpensive medicine of side effect and become the target that countries in the world pharmaceutical manufacturer is chased.The European Community has carried out unified legislation to medical herbs, state medical herbs status such as Canada and Australia have legalized, U.S. government has also drafted the plant amedica management method, the compound recipe mix preparation that begins to accept natural drug is as curative, and these provide good international environment for Chinese medicine enters international medical market as curative.On the other hand, along with the quickening of global economic integration progress, particularly China becomes a full member of WTO, and Chinese Medicine market incorporates the breadth and depth of international medical big market and will further aggravate.Face the enormous impact of Asian countries's traditional medicine product such as the keen competition of powerful transnational medical group and Japan, Korea S, India, Thailand and European countries' plant amedica such as Germany, France, numerous products that China's Chinese medicine produces are owing to still can not meet the standard of international medical market and requirement and being kept outside of the door.
Expansion and human back to nature requirement along with the market global range, use the low medicine of toxic and side effects, especially pure natural medical more and more becomes people's first-selection, dropping pill formulation be a kind of have efficient, quick-acting new medicine preparations, it has overcome the shortcoming and deficiency of Chinese medicine preparation in the past, but present dropping pill formulation generally faces following problem: 1, drop pill adjuvant pure natural degree is not high: at present, drop pill substrate adjuvant mostly is synthetic, natural degree is lower, the searching of new alternative substrate adjuvant, the searching of the alternative substrate adjuvant that particularly natural degree is high and preparation technology thereof determine, it is again very difficult thing, because the required preparation condition of at present common possible natural substrates adjuvant succedaneum is very harsh, it all is to influence the key that drop pill prepares molding that adjuvant temperature and drop pill thereof drip the system condition.The too high then viscosity of adjuvant melt temperature is low, and poor plasticity is though the adjuvant melt temperature is crossed lowplastcity by force, but drop pill has shortcomings such as easily sticking ball, distortion, therefore, seek pure natural degree height, and the adjuvant that is suitable for substituting existing drop pill substrate is a very job of hardships.2, the drop pill outlet encounters problems: along with expanding economy, more and more internationalize in market, China is also just making great efforts to adapt to this trend, present Chinese medicine dripping pills preparation as health food, successful export to many countries, but also face many problems at present, because different countries is different to the approval of the selected adjuvant of Chinese medicine dropping pill formulation, especially industrial flourishing Europe, more strict to food adjuvant and medical auxiliary materials, and as the selected chemosynthesis adjuvant (as Polyethylene Glycol) of the dropping pill formulation of health food outlet not in the catalogue of some national food additive, it is very unfavorable that this moves towards the international market to the Chinese medicine dropping pill formulation, becomes the stumbling-block that Chinese medicine enters the international market, therefore, seek the new of one or more, can be particularly important, also very urgent for the substrate adjuvant that the international market is accepted.3, the shortcoming of mouthfeel and onset speed: the mouthfeel of Chinese medicine and preparation thereof is relatively poor to be the big characteristics of one, people when taking some drugs to the frightened of disagreeable taste that medicine had even be better than fear far away to disease, What is more, some patients are because can not overcome the poor taste of Chinese medicine or its preparation or abnormal smells from the patient and abandon the treatment of Chinese medicine, though can improve mouthfeel as medicine being made capsule or sugar coated tablet, reducing stimulates, but disintegration rate prolongs, be unfavorable for the rapid onset of medicine, to some disease, particularly need the disease of the rapid onset of medicine inapplicable.4, the preparation process difficulty of drop pill suitability for industrialized production: in the replacement process of dropping pill formulation adjuvant, determining of the preparation process of its suitability for industrialized production is very difficult something, as the ratio of the melt temperature of substrate adjuvant, the proportioning of dripping system temperature, adjuvant and medicine, dropper bore, condensing agent etc. all are the factors that influence drop pill, therefore, the replacement of substrate and to be suitable for suitability for industrialized production be a job consuming time, as to expend substantial contribution.
In order to change drop pill substrate adjuvant for a long time based on the situation of chemosynthesis adjuvant, it is low to solve the pure natural degree that present drop pill substrate faced, and can not satisfy more and more that people require back to nature, take low toxicity, the problem of the pure natural medical that has no side effect; Also can solve some problems that Chinese medicine preparation, particularly dropping pill formulation are run in exit procedure, strengthen the competitiveness of international market; The present invention has invented the pure Chinese medicine dripping pills preparation that a kind of toxic and side effects is low, evident in efficacy, moderate, adapt to industrialized great production by a large amount of tests and the research of preparation process.
Summary of the invention
The medicine that the purpose of this invention is to provide a kind of treatment pharyngitis with new type natural substrate adjuvant preparation.
Another object of the present invention provides a kind of preparation method for the treatment of pharyngitis pharmaceutical preparation.
The selected substrate adjuvant of the present invention is resulting by a large amount of tests, it is little to have molecular weight, soluble in water, and molten diffusing speed is faster, pure natural degree height, toxic and side effects is lower, and can reduce the medicine irritation abnormal smells from the patient, has the oral cavity of improvement acid-base value during the buccal of oral cavity, improve the characteristics of oral cavity smell, the used substrate adjuvant of the present invention is the agent of food sedan-chair flavor, takes that mouthfeel is good, the acceptant characteristics of patient, is the direction of following substrate adjuvant development.
The consumption of drug component of the present invention and the selection of adjuvant thereof also grope to sum up to draw through the inventor in a large number, each amounts of components all has curative effect preferably in following ranges: 1～5 part of Indigo Naturalis, 1～5 part in Radix Glycyrrhizae, 1～4 part of Fructus Chebulae, 1～4 part of Mentholum, 0.2～1.2 part of Borneolum Syntheticum, 0.1～0.7 part of artificial Calculus Bovis, appropriate amount of auxiliary materials is made, wherein adjuvant comprises filler and plasticity substrate, said filler is selected from the natural adjuvant of following one or more plant origins: erythritol, sorbitol, fructose, D-ribonic acid-gamma lactone, arabitol, trehalose, D-ribose, low melting-point agarose, Lac, xylitol, Raffinose, glucose, malic acid, citric acid, isomalt, lactose, maltose etc., and they contain the water of crystallization chemical compound; Said plasticity substrate is selected from the natural adjuvant of following one or more plant origins: starch and derivant thereof, cellulose and derivant thereof, arabic gum, dextran, chitin, sesbania gum, carrageenan, Ficus elastica, Furcellaran, tragakanta, carrageenin, tamarind gum, pectin, xanthan gum, alginic acid and salt thereof, dextrin, cyclodextrin, agar, lactose; Described starch and derivant thereof such as pregelatinized Starch, modified starch, hydroxypropyl starch, carboxymethyl starch, described cellulose and derivant thereof such as methylcellulose, microcrystalline Cellulose, sodium carboxymethyl cellulose, hydroxypropyl emthylcellulose, cross-linking sodium carboxymethyl cellulose, hydroxyethylmethyl-cellulose, hydroxyethyl-cellulose, hydroxypropyl cellulose; Be chosen as 2～4 parts of the Indigo Naturaliss, 2～4 parts in Radix Glycyrrhizae, 2～3 parts of Fructus Chebulaes, 2～3 parts of Mentholums, 0.34～0.8 part of Borneolum Syntheticum, 0.3～0.5 part of artificial Calculus Bovis, appropriate amount of auxiliary materials of preferred drug component consumption of the present invention and adjuvant thereof are made, filler adjuvant wherein is selected from the natural adjuvant of following one or more plant origins: sorbitol, xylitol, lactose, maltose, and they contain the water of crystallization chemical compound; Plasticity substrate wherein is selected from the natural adjuvant of following one or more plant origins: pregelatinized Starch, carboxymethyl starch, methylcellulose, sodium carboxymethyl cellulose, hydroxypropyl emthylcellulose, arabic gum, alginic acid, dextrin, cyclodextrin, agar, lactose; Be chosen as 3.33 parts of the Indigo Naturaliss, 3.33 parts in Radix Glycyrrhizae, 2.67 parts of Fructus Chebulaes, 2.67 parts of Mentholums, 0.67 part of Borneolum Syntheticum, 0.4 part of artificial Calculus Bovis, appropriate amount of auxiliary materials of best drug component consumption of the present invention and adjuvant thereof are made, and filler adjuvant wherein is selected from the natural adjuvant of following one or more plant origins: xylitol, lactose; Plasticity substrate wherein is selected from the natural adjuvant of following one or more plant origins: starch, arabic gum.
Can also contain chemosynthesis adjuvant and animal origin adjuvant in the above-mentioned dressing, wherein filler comprises phenylglycol, hexadecanol, octadecanol, sodium stearate, tristerin, tripalmitin, carbamide, polyoxyethylene monostearate, polyoxyethylene alkyl ether; Wherein plasticity substrate comprises polyvinylpyrrolidone, crospolyvinylpyrrolidone, carbomer, polyvinyl alcohol, acrylic resin, poloxamer, gelatin.
In screening to above adjuvant, we find: plant colloid such as carrageenan, the tragakanta, pectin, agar, arabic gum, Ficus elastica, tamarind gum, locust bean gum, Pseudobulbus Bletillae (Rhizoma Bletillae) glue, guar gum, Konjac glucomannan, it is big that plant colloids such as POLY-karaya have viscosity, mobile poor, characteristics such as do not solidify after the condensation, and arabic gum has high dense low sticking character, can be mixed with the aqueous solution of 50% concentration and still have flowability, this is one of not available characteristics of other hydrophilic colloid, arabic gum has at high temperature, under the low concentration, can ooze, but not condensation, at low temperature, under the high concentration, be difficult for oozing, but characteristics such as energy condensation.Polysaccharide such as polysaccharide such as starch and derivant thereof (as gelling starch, carboxymethyl starch etc.), cellulose derivative (as methylcellulose, sodium carboxymethyl cellulose, hydroxypropyl emthylcellulose etc.), alginic acid, dextrin, cyclodextrin, lactose, in screening, find alginic acid have viscosity big, be the fruit jelly sample, dextrin has the colloid sample, characteristics such as lactose coagulability difference; And starch and derivant thereof are materials commonly used in the medical science adjuvant, thus in polysaccharide preferred starch and derivant thereof.Polyhydric alcohol such as sorbitol (88～102 ℃), xylitol (88～94.5 ℃), lactose (70～80 ℃), mannitol (166～169 ℃), maltose alcohol (135～140 ℃), isomalt polyhydric alcohol such as (98～103 ℃) screen, and find that it has following characteristics as drop pill substrate: sorbitol, lactose, isomalt are mobile poor; Mannitol, maltose alcohol fusing point are too high; The xylitol coagulability is poor slightly.After Preliminary screening, preferred xylitol, lactose, sorbitol in the selection of polyhydric alcohol, the best is an xylitol.Xylitol has following characteristics as drop pill substrate: in the time of 91 ℃, molten condition has appearred in xylitol, but not fusion fully, cooling rapidly, it separates out crystallization very soon, xylitol mixes the back good fluidity with extractum at certain proportion, can drip and can condensation, but be condensed into Powdered thing, loosely organized, the toughness extreme difference, that pinches is promptly broken.Organic acid and salt, alkali such as citric acid (100 ℃), sorbic acid (133 ℃), succinic acid (181～189 ℃), sodium acetate organic acid such as (58 ℃) and salt, alkali, its as drop pill substrate have fusing point too high, with Chinese medical concrete can't mixing etc. shortcoming.
Because of above single adjuvant existing shortcoming in as the drop pill preparation process, particularly we by above-mentioned Preliminary screening after, determine two kinds of adjuvants are used and screen: mainly be that above various adjuvants are carried out combined sorting, final determine following several: the plant colloid cooperates with the plant colloid, the cooperating of polyhydric alcohol and polyhydric alcohol, polyhydric alcohol and plant colloidally cooperate, the cooperating of the cooperating of xylitol and arabic gum, lactose and arabic gum, based on the composite auxiliary material of xylitol.Find preferred the cooperation to be xylitol, lactose and the compound use of other adjuvant, this kind combination has following characteristics: make up with mannitol: can drip not condensation; Make up with sorbic acid: both do not dissolve each other; Make up with lactose: can drip the energy condensation, but frangible; Make up with pomelo-pectin, tragakanta, sodium alginate: viscosity is big, can't drip; Make up with arabic gum: can drip, coagulability is poor slightly; Make up with dextrin: can drip, coagulability is poor slightly; Make up with starch: can drip, coagulability is also better.Determine that at last best of breed is that xylitol cooperates with arabic gum with starch, xylitol with starch, lactose.
At xylitol and starch, lactose and starch, in the research of xylitol and arabic gum combination, xylitol and starch Application of composite being prepared some required in the process of drop pill factors investigated, mainly is to the xylitol type, condensed fluid, condensate temperature influences the drop pill mouldability, xylitol and starch proportion influence mouldability, temperature is to the influence of drop pill mouldability, the extractum amount influences the drop pill mouldability, mixing time influences the drop pill mouldability, the dropper bore is to the influence of drop pill particle diameter, the formulation optimization of drop pill, the Preliminary Determination of drop pill, dissolve scattered time limit is investigated.Find that the solid xylitol has three types of powder, granular and crystallinity, and the easiest fusion of powder xylitol, again can fine dissolving be dispersed in the mixed liquor that starch, extractum forms, good fluidity, drippage is easy, and granular and crystalline xyhose alcohol is difficult for fusion, solubility property is also slightly poor, the mix flow that they and starch, extractum form is relatively poor, viscosity is very big, almost cannot drip, and therefore drips first-selected powder xylitol in the system process at drop pill.
At ratio of adjuvant molding is found in the sex research, in the combination of xylitol and starch, lactose and starch, xylitol and arabic gum, low melting point substrate adjuvant is 1: 0～1: 1.5 with the ratio of the weight of plasticity substrate adjuvant, be preferably 1: 0.1～1: 0.9, the best is 1: 0.1～1: 0.5.Low melting point substrate adjuvant of being formed within this scope and plasticity substrate adjuvant, the drug matrices fused solution all can ooze, and can condensation.Specific to each combination, xylitol is preferably 1: 0.2 with the ratio of the weight of starch～1: 0.3, and lactose is preferably 1: 0.2 with the ratio of the weight of starch～1: 0.3, and the ratio of the weight of xylitol and arabic gum is preferably 1: 0.2～and 1: 0.4.Find that in the research of temperature temperature is big especially to the influence of drop pill mouldability to the influence of drop pill mouldability, when temperature is too low, owing to the too big effect that oozes that influences drop pill of viscosity of substrate, when temperature is too high, not condensation of drop pill.Find that mixing time can have influence on the mouldability of drop pill in mixing time in to the sex research of drop pill molding, mixing time is too short, and mobile poor, influence oozes, and mixing time is oversize, influences the condensation of drop pill.Dripping under the system temperature, mixing time in 1～120 minute all can, suitable mixing time was at 10～30 minutes.Consider that mixing time can not be too short in the suitability for industrialized production, adopt the method that low temperature stirs for a long time, high temperature drips system.Find that in the research of dropper bore to the influence of drop pill particle diameter the dropper bore influences the size of drop pill and the flowability of fusion substrate, the system effect is dripped in influence.Drop pill diminishes and diminishes along with bore, but after 1.4 millimeters, along with the bore change of size that diminishes is not obvious, but the matrix flow reduction, system is dripped in influence.
So in the preparation method of preparation, medicine mixes mixing time with the substrate adjuvant be 10～30 minutes; The mixed heating and melting temperature of medicine and substrate adjuvant is 45～115 ℃, dripping the system temperature is 45～95 ℃, and liquid coolant is liquid paraffin, methyl-silicone oil or vegetable oil (Oleum Glycines, Semen Ricini wet goods), and the temperature of liquid coolant is-20～25 ℃, dropper mouth internal diameter is 1.0～4.0 millimeters; Preferred heating and melting temperature is 60～85 ℃, and dripping a system temperature is 60～85 ℃, and condensing agent is liquid paraffin, methyl-silicone oil, and the condensing agent temperature is 0～18 ℃, and the dropper bore is 1.1～3.5 millimeters, and the difference of dropper mouth external diameter and internal diameter is less for well; Best heating and melting temperature is that to make temperature be that 64 ℃, dropper bore are that 1.2～2.5 millimeters, condensing agent are 0 ℃ methyl-silicone oil to 64 ℃, droplet.
The substrate adjuvant of the best of the present invention is xylitol and starch, and xylitol is 1: 0.2～1: 0.3 with the ratio of the weight of starch; Or be lactose and starch, lactose is 1: 0.2～1: 0.3 with the ratio of the weight of starch; Or be xylitol and arabic gum, the ratio of the weight of xylitol and arabic gum is 1: 0.2～1: 0.4.
Xylitol is a kind of natural plant sweetening agent, approve through World Health Organization (WHO), xylitol is a kind of safest sweeting agent, countries in the world are extensive use of in fields such as food and oral-cavity articles, xylitol enters the help that need not insulin in the cell, when sugar utilizes obstacle, can not cause blood sugar increasing yet, can improve diabetics symptom, have the ketoplastic effect of powerful inhibition, can promote the generation of liver glycogen, directly infiltrate the Developmental and Metabolic Disorder that tissue is participated in metabolism, can be corrected protein, fat and steroid; Xylose is the internal metabolism intermediate product, and body has higher toleration to it.Clinical practice proves: the highest oral dosis tolerata can reach 220g every day, and intravenous drip every day can reach 100g.The oral 25700mg/Kg of median lethal dose(LD 50) (LD50) mice, quiet notes 6400mg/Kg, the quiet notes of rat 6200mg/Kg.
Medicine mesostroma adjuvant of the present invention and amount of drug are than can being the scope that allows on the galenic pharmacy, medicine described here can be that crude drug also can be the effective ingredient extract, in order to adapt to industrialized great production, the ratio range of mesostroma adjuvant of the present invention and medicine refers to the weight proportion of adjuvant and extract drugs extractum, and the substrate adjuvant is 1: 0.1～1: 1 with the ratio of the weight of drug extract; Preferred substrate adjuvant is 1: 0.1～1: 0.6 with the ratio of the weight of extract drugs extractum; Best substrate adjuvant is 1: 0.2～1: 0.4 with the ratio of the extraction extractum weight of medicine.
Medicine of the present invention can adopt the preparation of Chinese medicine preparation conventional method.The preparation of effective ingredient of the present invention can be adopted following method: water extraction, decoction and alcohol sedimentation technique, extraction, infusion process, percolation, reflux extraction, continuous backflow extraction method, macroreticular resin absorbing method preparation.For example, these crude drug pulverize mix homogeneously can be made powder takes after mixing it with water; Also can be with these medicines decocting together, the condensed water decocting liquid is made oral liquid then; But, preferably adopt following technology to extract, but this can not limit protection scope of the present invention to raw material in order to make each crude drug of this medicine better bring into play drug effect.
The preparation method of medicine of the present invention is as follows:
(a): it is standby to get 1～5 part of Indigo Naturalis, 1～5 part in Radix Glycyrrhizae, 1～4 part of Fructus Chebulae, 1～4 part of Mentholum, 0.2～1.2 part of Borneolum Syntheticum, 0.1～0.7 part of artificial Calculus Bovis, appropriate amount of auxiliary materials;
(b): get the Fructus Chebulae and add 10～30 times, 5～15 times moisture and got indescribably 0.5～3 hour, 0.5～2 hour, filter, merging filtrate is condensed into cream, add 4～12 times of 80～99% ethanol, 2～10 times of precipitate with ethanol 1～3 time, get supernatant and reclaim ethanol to 85 ℃, relative density 1.05～1.45; After getting hydrochloric acid that Indigo Naturalis adds 2～6 times 9～27% and fully soaking, with boiling water elder generation sucking filtration to neutral, oven dry; Extracting liquorice adds suitable quantity of water, and decocting in water 2～4 times extracted 1～4 hour at every turn, merge extractive liquid, is concentrated into 85 ℃, relative density 1.05～1.45, adds ethanol to 75%, leave standstill, incline and get supernatant, add ammonia and transfer PH8～8.5 to filter, reclaim ethanol to the thick paste shape, add the water that is equivalent to the supernatant liquid measure, slowly add hydrochloric acid to PH2～3, sedimentation and filtration, frozen water is washed 1～5 time, volatilizes naturally 1～6 hour;
(c): get an amount of substrate adjuvant and add the refining Indigo Naturalis of above-mentioned processing and fully stir; filter; add Radix Glycyrrhizae extractum, Fructus Chebulae's cream, artificial Calculus Bovis, Borneolum Syntheticum, Mentholum successively and make mix homogeneously; mixture stirs at 45～115 ℃ of heating and meltings, and mixing time is 1～120 minute; insulation; be 1.0～4.0 millimeters at 45～95 ℃ of temperature following system, dropper bore and splash in-20～25 ℃ liquid paraffin, methyl-silicone oil or the vegetable oil, make drop pill, promptly.
Preferred manufacturing procedure comprises the following steps:
(a): it is standby to get 2～4 parts of Indigo Naturaliss, 2～4 parts in Radix Glycyrrhizae, 2～3 parts of Fructus Chebulaes, 2～3 parts of Mentholums, 0.34～0.8 part of Borneolum Syntheticum, 0.3～0.5 part of artificial Calculus Bovis, appropriate amount of auxiliary materials;
(b): get the Fructus Chebulae and add 15～25 times, 8～12 times moisture and got indescribably 1～2 hour, 0.75～1.5 hour, filter, merging filtrate is condensed into cream, add 6～10 times of 90～97% ethanol, 4～6 times of precipitate with ethanol 2 times, get supernatant and reclaim ethanol to 85 ℃, relative density 1.15～1.30; After getting hydrochloric acid that Indigo Naturalis adds 3～5 times 15～20% and fully soaking, with boiling water elder generation sucking filtration to neutral, oven dry; Extracting liquorice adds suitable quantity of water, and decocting in water 3 times extracted 1.5～3.5 hours at every turn, merge extractive liquid, is concentrated into 85 ℃, relative density 1.15～1.30, adds ethanol to 75%, leave standstill, incline and get supernatant, add ammonia and transfer PH8～8.5 to filter, reclaim ethanol to the thick paste shape, add the water that is equivalent to the supernatant liquid measure, slowly add hydrochloric acid to PH2～3, sedimentation and filtration, frozen water is washed 2～3 times, volatilizes naturally 1.5～3.5 hours;
(c): get an amount of substrate adjuvant and add the refining Indigo Naturalis of above-mentioned processing and fully stirred 5～20 minutes; filter; add Radix Glycyrrhizae extractum, Fructus Chebulae's cream, artificial Calculus Bovis, Borneolum Syntheticum, Mentholum successively and make mix homogeneously; mixture is at 60～85 ℃ of heating and meltings; stir; mixing time is 10～30 minutes; insulation; being 1.1～3.5 millimeters at 60～85 ℃ of temperature following system, dropper bore splashes in 0～18 ℃ the liquid paraffin, methyl-silicone oil; liquid coolant is use up and wiped to the drop pill drop that forms; back packing to be dried is made drop pill, promptly.
Best preparation method comprises the following steps:
(a): it is standby to get 3.33 parts of Indigo Naturaliss, 3.33 parts in Radix Glycyrrhizae, 2.67 parts of Fructus Chebulaes, 2.67 parts of Mentholums, 0.67 part of Borneolum Syntheticum, 0.4 part of artificial Calculus Bovis;
(b): get the Fructus Chebulae and add 20 times, 10 times moisture and got indescribably 1.5 hours, 1 hour, filter, merging filtrate is condensed into 1: 2 cream, adds 8 times of 95% ethanol, 5 times of precipitate with ethanol 2 times, gets supernatant and reclaims ethanol to 85 ℃, relative density 1.2～1.25; After getting hydrochloric acid that Indigo Naturalis adds 4 times 18% and fully soaking, with boiling water elder generation sucking filtration to neutral, oven dry; Extracting liquorice adds suitable quantity of water, decocting in water 3 times, and this extracted 2 hours, merge extractive liquid, is concentrated at 85 ℃, relative density 1.18～1.23 and adds ethanol to 75%, leaves standstill, incline and get supernatant, add ammonia and transfer PH8～8.5 to filter, reclaim ethanol, add the water that is equivalent to the supernatant liquid measure to paste, slowly add hydrochloric acid PH2～3, sedimentation and filtration, frozen water are washed 2～3 times, volatilize naturally 2～3 hours;
(c): get an amount of substrate adjuvant and add the refining Indigo Naturalis of above-mentioned processing and fully stirred 10 minutes, filter, add Radix Glycyrrhizae extractum, Fructus Chebulae's cream, artificial Calculus Bovis, Borneolum Syntheticum, Mentholum successively and make mix homogeneously; mixture is at 64 ℃ of heating and meltings; stir, mixing time is 10～30 minutes, insulation; at 64 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters; splash in 0 ℃ the methyl-silicone oil, to the greatest extent and wipe liquid coolant, back packing to be dried the drop pill drop that forms; make drop pill, promptly.
The best preparation method of medicine of the present invention is:
(a): it is standby to get 3.33 parts of Indigo Naturaliss, 3.33 parts in Radix Glycyrrhizae, 2.67 parts of Fructus Chebulaes, 2.67 parts of Mentholums, 0.67 part of Borneolum Syntheticum, 0.4 part of artificial Calculus Bovis;
(b): get the Fructus Chebulae and add 20 times, 10 times moisture and got indescribably 1.5 hours, 1 hour, filter, merging filtrate is condensed into 1: 2 cream, adds 8 times of 95% ethanol, 5 times of precipitate with ethanol 2 times, gets supernatant and reclaims ethanol to 85 ℃, relative density 1.2～1.25; After getting hydrochloric acid that Indigo Naturalis adds 4 times 18% and fully soaking, with boiling water elder generation sucking filtration to neutral, oven dry; Extracting liquorice adds suitable quantity of water, decocting in water 3 times, and this extracted 2 hours, merge extractive liquid, is concentrated at 85 ℃, relative density 1.18～1.23 and adds ethanol to 75%, leaves standstill, incline and get supernatant, add ammonia and transfer PH8～8.5 to filter, reclaim ethanol, add the water that is equivalent to the supernatant liquid measure to paste, slowly add hydrochloric acid PH2～3, sedimentation and filtration, frozen water are washed 2～3 times, volatilize naturally 2～3 hours;
(c): the ratio of getting weight is 1: 0.2～1: 0.3 the xylitol and the mixture of starch; Or the ratio of weight is 1: 0.2～1: 0.3 the lactose and the mixture of starch; Or the ratio of weight is that the mixture of 1: 0.2～1: 0.4 xylitol and arabic gum adds the refining Indigo Naturalis of above-mentioned processing and fully stirred 10 minutes; filter; add Radix Glycyrrhizae extractum, Fructus Chebulae's cream, artificial Calculus Bovis, Borneolum Syntheticum, Mentholum successively and make mix homogeneously; mixture is at 64 ℃ of heating and meltings; stir; mixing time is 10～30 minutes; insulation; at 64 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters; splash in 0 ℃ the methyl-silicone oil, to the greatest extent and wipe liquid coolant, back packing to be dried the drop pill drop that forms; make drop pill, promptly.
More than form when producing and to increase or to reduce according to corresponding ratio, as large-scale production can be unit with kilogram or with the ton, small-scale production can be unit with the gram also, and weight can increase or reduce, but the crude drug material weight proportion constant rate between each composition.
More than each single medicinal material, especially adjuvant drug, messenger drug or adjuvant drug and messenger drug in forming, can be replaced by suitable Chinese medicine individually or simultaneously with the identical property of medicine, effect, it is constant to replace back Chinese medicine preparation and drug effect thereof.
Medicine of the present invention can be determined usage and dosage according to patient's situation in use, but every day 1-3 time, and every day, each crude drug consumption was as the criterion with the state-promulgated pharmacopoeia dosage, was no more than the pharmacopeia ormal weight.
The drop pill that the present invention is prepared, conventional drop pill advantage is simple as preparing except having, steady quality, can make liquid medicine solidification, convenient drug administration, efficient, quick-acting, its biggest advantage is:
1, the selected adjuvant pure natural of the present invention degree height: the substrate adjuvant that employed substrate adjuvant derives from natural plants or originates based on natural plants among the present invention, selected substrate adjuvant is xylitol and starch or lactose and starch or xylitol and arabic gum, this substrate adjuvant has pure natural degree height, toxic and side effects is low, mouthfeel is good, dissolve scattered time limit is short, rapid-action, it is a kind of new medium adjuvant, can be used for substituting present chemosynthesis adjuvant, the drop pill made from this kind adjuvant, it is low to solve the pure natural degree that present drop pill substrate faced, and more and more can not satisfy people and require back to nature, take low toxicity, the problem of the pure natural medical that has no side effect.
2, some problems in the outlet of solution Chinese medicine: medicine of the present invention also can solve Chinese medicine preparation, some problems of in exit procedure, being run into of dropping pill formulation particularly, solve because different countries, especially the European countries of industry prosperity are to the difference identification of the selected adjuvant of Chinese medicine dropping pill formulation, overcome as the selected adjuvant Polyethylene Glycol of the dropping pill formulation of the health food outlet defective in some national food additive catalogue not, improve the Chinese medicine dripping pills preparation and move towards the international market, strengthen the competitiveness of international market.
3, solve the relatively poor problem of dropping pill formulation taste and further improve drug effect speed (dissolve scattered time limit): the medicinal dropping ball made from this kind substrate adjuvant of the present invention, can improve Chinese medicine preparation, the particularly present not good shortcoming of dropping pill formulation taste, improve mouthfeel, more easy for patients to accept, and the drop pill that adopts the selected adjuvant of medicine of the present invention to make has shorter dissolve scattered time limit, making drug effect faster, is the medicine that pharyngitis is treated in a kind of onset faster.
4, higher safety and solve some problems in the drop pill storage process: the selected substrate of the present invention is not only additive, nutrient commonly used in the food industry, and can do medicinal, but do not see that it uses as the drug matrices adjuvant, therefore, with regard to substrate, be perfectly safe, have no side effect, a large amount of evidences, the drop pill made from this adjuvant can reduce effective ingredient separating out in storage process, the sticking ball of drop pill, easy shortcomings such as moisture absorption deliquescing, but the big production of suitability for industrialized.
The present invention is under instruction of Chinese Medicine theory, preparation technology's test that process is a large amount of and pharmacology, the resulting preparation of pharmacodynamics test.The present invention is evident in efficacy, has wind and heat dispersing, and the effect of resolving toxin and disinhibiting the throat is used for acute pharyngitis due to wind-heat clinically, pharyngalgia, dry pharynx, thirsty; Or micro evil wind, heating, red swelling of the pharynx, tongue tip side of red, white and thin fur or BOHUANG, floating and rapid pulse or sliding number person are suitable for acute pharyngitis and see above-mentioned patient.Reasonable recipe of the present invention, poisonous side effect of medicine is low, it is bigger to have overcome the side effect of western medicine coronary heart disease, and the Chinese medicine curative effect is low, flavour of a drug are many or the substrate adjuvant has the shortcoming of certain toxic and side effects, is the medicine of the acute and chronic pharyngitis of treatment determined of a kind of economy, material benefit, curative effect.
In order to understand the present invention better, below with test explanation advantages of the present invention such as the dissolve scattered time limit of new substrate QINGYAN DIWAN and the QINGYAN DIWAN made for the substrate adjuvant with the Polyethylene Glycol, drop pill soft durometer, the sticking balls of drop pill.
Test example 1: dissolve scattered time limit, weight differential contrast experiment's example
In vitro tests
The present invention be that the QINGYAN DIWAN that adjuvant is made compares with the Polyethylene Glycol, by measuring dissolve scattered time limit, investigate its good releasing effect; By measuring indexs such as the ball method of double differences is different, whether ripe, whether be fit to suitability for industrialized production if investigating its preparation technology.
1. test medication: the new substrate QINGYAN DIWAN of the present invention (newly) is the QINGYAN DIWAN (old) that adjuvant is made with the Polyethylene Glycol.
2. method and result:
Dissolve scattered time limit: by " method is measured under this item of Chinese pharmacopoeia; The ball method of double differences is different: by " method is measured under this item of Chinese pharmacopoeia.Result of the test sees Table 1.
Three batches of QINGYAN DIWAN made from the new medium adjuvant of table 1 (newly) with the Polyethylene Glycol be QINGYAN DIWAN (old) dissolve scattered time limit made of adjuvant, weight differential relatively
Test data shows, the dissolve scattered time limit of new substrate QINGYAN DIWAN is that the QINGYAN DIWAN made of adjuvant is few with the Polyethylene Glycol; The ball amount difference of the QINGYAN DIWAN that new and old substrate is made all is controlled in the pharmacopeia prescribed limit.The result of the test explanation, the molten diffusing speed of the QINGYAN DIWAN that novel adjuvant is made is faster, is more conducive to medicine and plays a role in the shortest time; The ball method of double differences is different all to be controlled in the pharmacopeia prescribed limit, and the alternative present chemosynthesis adjuvant of this natural substrates adjuvant is described, but suitability for industrialized production.
Test example 2: the present invention with the Polyethylene Glycol be the sticking ball comparative observation of QINGYAN DIWAN soft durometer, drop pill that adjuvant is made
The present invention be that the QINGYAN DIWAN that adjuvant is made compares with the Polyethylene Glycol, by measuring indexs such as above-mentioned, investigate its effect.
1. test medication: the new substrate QINGYAN DIWAN of the present invention (newly) is provided by the Jinshili Medicine Research ﹠. Development Co., Ltd., Tianjin; With the Polyethylene Glycol is the QINGYAN DIWAN (old) that adjuvant is made, commercially available.
2. method and result:
Get three batches of new, old substrate QINGYAN DIWAN, be loaded in the porcelain vase respectively, and use the bottle stopper good seal.Putting it into the bottom has in the exsiccator of saturated Nacl (humidity 75%) solution, exsiccator is put into 40 ℃ of drying baker of constant temperature again, and timing sampling is observed situations such as drop pill soft durometer, the sticking ball of drop pill, the results are shown in Table 2.1, table 2.2.
Three batches in table 2.1 is that the QINGYAN DIWAN reserved sample observing that adjuvant is made compares with the Polyethylene Glycol
Table 2.2: three batches of QINGYAN DIWAN made from the new medium adjuvant (newly) with the Polyethylene Glycol be QINGYAN DIWAN (old) character observation made of adjuvant relatively
Test data shows, new substrate QINGYAN DIWAN soft durometer changes and be that the QINGYAN DIWAN made of adjuvant is similar, strong slightly with the Polyethylene Glycol; The sticking ball variation of new substrate QINGYAN DIWAN, firmness change and be that the QINGYAN DIWAN made of adjuvant is similar with the Polyethylene Glycol.Presentation of results, the sticking ball of the QINGYAN DIWAN that new and old substrate adjuvant is made changes, firmness change is similar, and the alternative present chemosynthesis adjuvant of this natural substrates adjuvant is described, but suitability for industrialized production.
The specific embodiment
Embodiment 1
(a): get Indigo Naturalis 3.33g, Radix Glycyrrhizae 3.33g, Fructus Chebulae 2.67g, Mentholum 2.67g, Borneolum Syntheticum 0.67g, artificial Calculus Bovis 0.4g xylitol 10g, starch 2g are standby;
(b): get the Fructus Chebulae and add 20 times, 10 times moisture and got indescribably 1.5 hours, 1 hour, filter, merging filtrate is condensed into 1: 2 cream, adds 8 times of 95% ethanol, 5 times of precipitate with ethanol 2 times, gets supernatant and reclaims ethanol to 85 ℃, relative density 1.2～1.25; After getting hydrochloric acid that Indigo Naturalis adds 4 times 18% and fully soaking, with boiling water elder generation sucking filtration to neutral, oven dry; Extracting liquorice adds suitable quantity of water, decocting in water 3 times, and this extracted 2 hours, merge extractive liquid, is concentrated at 85 ℃, relative density 1.18～1.23 and adds ethanol to 75%, leaves standstill, incline and get supernatant, add ammonia and transfer PH8～8.5 to filter, reclaim ethanol, add the water that is equivalent to the supernatant liquid measure to paste, slowly add hydrochloric acid PH2～3, sedimentation and filtration, frozen water are washed 2～3 times, volatilize naturally 2～3 hours;
(c): the mixture of getting xylitol and starch adds the refining Indigo Naturalis of above-mentioned processing and fully stirred 10 minutes; filter; add Radix Glycyrrhizae extractum, Fructus Chebulae's cream, artificial Calculus Bovis, Borneolum Syntheticum, Mentholum successively and make mix homogeneously; mixture is at 64 ℃ of heating and meltings; stir; mixing time is 10～30 minutes; insulation; at 64 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters; splash in 0 ℃ the methyl-silicone oil, to the greatest extent and wipe liquid coolant, back packing to be dried the drop pill drop that forms; make 1000 drop pill, promptly.
Embodiment 2
(a): get Indigo Naturalis 3.33g, Radix Glycyrrhizae 3.33g, Fructus Chebulae 2.67g, Mentholum 2.67g, Borneolum Syntheticum 0.67g, artificial Calculus Bovis 0.4g, lactose 11.5g, starch 2g are standby;
(b): get the Fructus Chebulae and add 20 times, 10 times moisture and got indescribably 1.5 hours, 1 hour, filter, merging filtrate is condensed into 1: 2 cream, adds 8 times of 95% ethanol, 5 times of precipitate with ethanol 2 times, gets supernatant and reclaims ethanol to 85 ℃, relative density 1.2～1.25; After getting hydrochloric acid that Indigo Naturalis adds 4 times 18% and fully soaking, with boiling water elder generation sucking filtration to neutral, oven dry; Extracting liquorice adds suitable quantity of water, decocting in water 3 times, and this extracted 2 hours, merge extractive liquid, is concentrated at 85 ℃, relative density 1.18～1.23 and adds ethanol to 75%, leaves standstill, incline and get supernatant, add ammonia and transfer PH8～8.5 to filter, reclaim ethanol, add the water that is equivalent to the supernatant liquid measure to paste, slowly add hydrochloric acid PH2～3, sedimentation and filtration, frozen water are washed 2～3 times, volatilize naturally 2～3 hours;
(c): the mixture of getting lactose and starch adds the refining Indigo Naturalis of above-mentioned processing and fully stirred 10 minutes; filter; add Radix Glycyrrhizae extractum, Fructus Chebulae's cream, artificial Calculus Bovis, Borneolum Syntheticum, Mentholum successively and make mix homogeneously; mixture is at 64 ℃ of heating and meltings; stir; mixing time is 10～30 minutes; insulation; at 64 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters; splash in 0 ℃ the methyl-silicone oil, to the greatest extent and wipe liquid coolant, back packing to be dried the drop pill drop that forms; make 1000 drop pill, promptly.
Embodiment 3
(a): get Indigo Naturalis 3.33g, Radix Glycyrrhizae 3.33g, Fructus Chebulae 2.67g, Mentholum 2.67g, Borneolum Syntheticum 0.67g, artificial Calculus Bovis 0.4g, xylitol 10.7g, arabic gum 4.3g are standby;
(b): get the Fructus Chebulae and add 20 times, 10 times moisture and got indescribably 1.5 hours, 1 hour, filter, merging filtrate is condensed into 1: 2 cream, adds 8 times of 95% ethanol, 5 times of precipitate with ethanol 2 times, gets supernatant and reclaims ethanol to 85 ℃, relative density 1.2～1.25; After getting hydrochloric acid that Indigo Naturalis adds 4 times 18% and fully soaking, with boiling water elder generation sucking filtration to neutral, oven dry; Extracting liquorice adds suitable quantity of water, decocting in water 3 times, and this extracted 2 hours, merge extractive liquid, is concentrated at 85 ℃, relative density 1.18～1.23 and adds ethanol to 75%, leaves standstill, incline and get supernatant, add ammonia and transfer PH8～8.5 to filter, reclaim ethanol, add the water that is equivalent to the supernatant liquid measure to paste, slowly add hydrochloric acid PH2～3, sedimentation and filtration, frozen water are washed 2～3 times, volatilize naturally 2～3 hours;
(c): the mixture of getting xylitol and arabic gum adds the refining Indigo Naturalis of above-mentioned processing and fully stirred 10 minutes; filter; add Radix Glycyrrhizae extractum, Fructus Chebulae's cream, artificial Calculus Bovis, Borneolum Syntheticum, Mentholum successively and make mix homogeneously; mixture is at 64 ℃ of heating and meltings; stir; mixing time is 10～30 minutes; insulation; at 64 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters; splash in 0 ℃ the methyl-silicone oil, to the greatest extent and wipe liquid coolant, back packing to be dried the drop pill drop that forms; make 1000 drop pill, promptly.
Embodiment 4
(a): get Indigo Naturalis 3.33g, Radix Glycyrrhizae 3.33g, Fructus Chebulae 2.67g, Mentholum 2.67g, Borneolum Syntheticum 0.67g, artificial Calculus Bovis 0.4g, xylitol 10g, starch 2.5g are standby;
(b): get the Fructus Chebulae and add 20 times, 10 times moisture and got indescribably 1.5 hours, 1 hour, filter, merging filtrate is condensed into 1: 2 cream, adds 8 times of 95% ethanol, 5 times of precipitate with ethanol 2 times, gets supernatant and reclaims ethanol to 85 ℃, relative density 1.2～1.25; After getting hydrochloric acid that Indigo Naturalis adds 4 times 18% and fully soaking, with boiling water elder generation sucking filtration to neutral, oven dry; Extracting liquorice adds suitable quantity of water, decocting in water 3 times, and this extracted 2 hours, merge extractive liquid, is concentrated at 85 ℃, relative density 1.18～1.23 and adds ethanol to 75%, leaves standstill, incline and get supernatant, add ammonia and transfer PH8～8.5 to filter, reclaim ethanol, add the water that is equivalent to the supernatant liquid measure to paste, slowly add hydrochloric acid PH2～3, sedimentation and filtration, frozen water are washed 2～3 times, volatilize naturally 2～3 hours;
(c): the mixture of getting xylitol and starch adds the refining Indigo Naturalis of above-mentioned processing and fully stirred 5～20 minutes; filter; add Radix Glycyrrhizae extractum, Fructus Chebulae's cream, artificial Calculus Bovis, Borneolum Syntheticum, Mentholum successively and make mix homogeneously; mixture is at 60～85 ℃ of heating and meltings; stir; mixing time is 10～30 minutes; insulation; being 1.1～3.5 millimeters at 60～85 ℃ of temperature following system, dropper bore splashes in 0～18 ℃ the liquid paraffin; liquid coolant is use up and wiped to the drop pill drop that forms; back packing to be dried is made 1000 drop pill, promptly.
Embodiment 5
(a): get Indigo Naturalis 3.33g, Radix Glycyrrhizae 3.33g, Fructus Chebulae 2.67g, Mentholum 2.67g, Borneolum Syntheticum 0.67g, artificial Calculus Bovis 0.4g, xylitol 12.3g, arabic gum 2.7g are standby;
(b): get the Fructus Chebulae and add 20 times, 10 times moisture and got indescribably 1.5 hours, 1 hour, filter, merging filtrate is condensed into 1: 2 cream, adds 8 times of 95% ethanol, 5 times of precipitate with ethanol 2 times, gets supernatant and reclaims ethanol to 85 ℃, relative density 1.2～1.25; After getting hydrochloric acid that Indigo Naturalis adds 4 times 18% and fully soaking, with boiling water elder generation sucking filtration to neutral, oven dry; Extracting liquorice adds suitable quantity of water, decocting in water 3 times, and this extracted 2 hours, merge extractive liquid, is concentrated at 85 ℃, relative density 1.18～1.23 and adds ethanol to 75%, leaves standstill, incline and get supernatant, add ammonia and transfer PH8～8.5 to filter, reclaim ethanol, add the water that is equivalent to the supernatant liquid measure to paste, slowly add hydrochloric acid PH2～3, sedimentation and filtration, frozen water are washed 2～3 times, volatilize naturally 2～3 hours;
(c): the mixture of getting xylitol and arabic gum adds the refining Indigo Naturalis of above-mentioned processing and fully stirred 5～10 minutes; filter; add Radix Glycyrrhizae extractum, Fructus Chebulae's cream, artificial Calculus Bovis, Borneolum Syntheticum, Mentholum successively and make mix homogeneously; mixture is at 60～85 ℃ of heating and meltings; stir; mixing time is 10～30 minutes; insulation; being 1.2～3.5 millimeters at 60～85 ℃ of temperature following system, dropper bore splashes in 0～18 ℃ the methyl-silicone oil; make 1000 drop pill; liquid coolant is use up and wiped to the drop pill drop that forms, back packing to be dried, promptly.
Embodiment 6
(a): get Indigo Naturalis 2g, Radix Glycyrrhizae 2g, Fructus Chebulae 2g, Mentholum 3g, Borneolum Syntheticum 0.34g, artificial Calculus Bovis 0.3g, xylitol 8g, erythritol 5g, methylcellulose 1.5g is standby;
(b): get the Fructus Chebulae and add 15 times, 8 times moisture and got indescribably 1.5 hours, 1 hour, filter, merging filtrate is condensed into cream, adds 8 times of 90～95% ethanol, 5 times of precipitate with ethanol 2 times, gets supernatant and reclaims ethanol to 85 ℃, relative density 1.15～1.30; After getting hydrochloric acid that Indigo Naturalis adds 4 times 18% and fully soaking, with boiling water elder generation sucking filtration to neutral, oven dry; Extracting liquorice adds suitable quantity of water, and decocting in water 3 times extracted 2.5 hours at every turn, merge extractive liquid, is concentrated into 85 ℃, relative density 1.15～1.30, adds ethanol to 75%, leave standstill, incline and get supernatant, add ammonia and transfer PH8～8.5 to filter, reclaim ethanol to the thick paste shape, add the water that is equivalent to the supernatant liquid measure, slowly add hydrochloric acid to PH2～3, sedimentation and filtration, frozen water is washed 2～3 times, volatilizes naturally 2～3 hours;
(c): get methylcellulose; erythritol; the xylitol mix homogeneously; adding the refining Indigo Naturalis of above-mentioned processing fully stirred 5～20 minutes; filter; add Radix Glycyrrhizae extractum successively; Fructus Chebulae's cream; the artificial Calculus Bovis; Borneolum Syntheticum; Mentholum makes mix homogeneously; mixture is at 60～85 ℃ of heating and meltings; stir; mixing time is 10～30 minutes; insulation is in following system of 60～65 ℃ of temperature; the dropper bore is 1.21～3.5 millimeters and splashes in 0～18 ℃ the methyl-silicone oil, makes 1000 drop pill; liquid coolant is use up and wiped to the drop pill drop that forms; back packing to be dried is made drop pill, promptly.
Embodiment 7
(a): get Indigo Naturalis 4g, Radix Glycyrrhizae 4g, Fructus Chebulae 2g, Mentholum 2g, Borneolum Syntheticum 0.8g, artificial Calculus Bovis 0.5g, trehalose 8.5g, hydroxypropyl emthylcellulose 1.5g, standby;
(b): get the Fructus Chebulae and add 20 times, 12 times moisture and got indescribably 2 hours, 1.5 hours, filter, merging filtrate is condensed into cream, adds 10 times of 90～95% ethanol, 5 times of precipitate with ethanol 2 times, gets supernatant and reclaims ethanol to 85 ℃, relative density 1.15～1.30; After getting hydrochloric acid that Indigo Naturalis adds 4 times 15～20% and fully soaking, with boiling water elder generation sucking filtration to neutral, oven dry; Extracting liquorice adds suitable quantity of water, and decocting in water 3 times extracted 2 hours at every turn, merge extractive liquid, is concentrated into 85 ℃, relative density 1.15～1.30, adds ethanol to 75%, leave standstill, incline and get supernatant, add ammonia and transfer PH8～8.5 to filter, reclaim ethanol to the thick paste shape, add the water that is equivalent to the supernatant liquid measure, slowly add hydrochloric acid to PH2～3, sedimentation and filtration, frozen water is washed 2～3 times, volatilizes naturally 2 hours;
(c): get trehalose, hydroxypropyl emthylcellulose mix homogeneously; adding the refining Indigo Naturalis of above-mentioned processing fully stirred 5～20 minutes; filter, add Radix Glycyrrhizae extractum, Fructus Chebulae's cream, artificial Calculus Bovis, Borneolum Syntheticum, Mentholum successively and make mix homogeneously, mixture is at 45～115 ℃ of heating and meltings; stir; mixing time is 1～120 minute, and insulation is 1.0～4.0 millimeters at 45～95 ℃ of temperature following system, dropper bore and splashes in-20～25 ℃ the vegetable oil; make 1000 drop pill, promptly.
Embodiment 8
(a): get Indigo Naturalis 3g, Radix Glycyrrhizae 3g, Fructus Chebulae 2g, Mentholum 2.8g, Borneolum Syntheticum 0.6g, artificial Calculus Bovis 0.4g, xylitol 18.g, xanthan gum 4.5g are standby;
(b): get the Fructus Chebulae and add 18 times, 9 times moisture and got indescribably 1.5 hours, 1 hour, filter, merging filtrate is condensed into cream, adds 7 times of 90～92% ethanol, 5 times of precipitate with ethanol 2 times, gets supernatant and reclaims ethanol to 85 ℃, relative density 1.15～1.30; After getting hydrochloric acid that Indigo Naturalis adds 2 times 17～19% and fully soaking, with boiling water elder generation sucking filtration to neutral, oven dry; Extracting liquorice adds suitable quantity of water, and decocting in water 3 times extracted 2.5 hours at every turn, merge extractive liquid, is concentrated into 85 ℃, relative density 1.15～1.30, adds ethanol to 75%, leave standstill, incline and get supernatant, add ammonia and transfer PH8～8.5 to filter, reclaim ethanol to the thick paste shape, add the water that is equivalent to the supernatant liquid measure, slowly add hydrochloric acid to PH2～3, sedimentation and filtration, frozen water is washed 2～3 times, volatilizes naturally 3 hours;
(c): get xylitol and xanthan gum mix homogeneously; adding the refining Indigo Naturalis of above-mentioned processing fully stirred 5～20 minutes; filter, add Radix Glycyrrhizae extractum, Fructus Chebulae's cream, artificial Calculus Bovis, Borneolum Syntheticum, Mentholum successively and make mix homogeneously, mixture is at 45～75 ℃ of heating and meltings; stir; mixing time is 1～20 minute, and insulation is 1.30～3.0 millimeters at 55～75 ℃ of temperature following system, dropper bore and splashes in-20～25 ℃ the methyl-silicone oil; make 1000 drop pill, promptly.
Embodiment 9
(a): get Indigo Naturalis 5g, Radix Glycyrrhizae 1g, Fructus Chebulae 1g, Mentholum 4g, Borneolum Syntheticum 0.2g, artificial Calculus Bovis 0.7g, xylitol 23.4g, Ficus elastica 3.6g are standby;
(b): get the Fructus Chebulae and add 25 times, 12 times moisture and got indescribably 2.5 hours, 1.5 hours, filter, merging filtrate is condensed into cream, adds 8 times of 80～90% ethanol, 6 times of precipitate with ethanol 2 times, gets supernatant and reclaims ethanol to 85 ℃, relative density 1.05～1.45; After getting hydrochloric acid that Indigo Naturalis adds 4 times 9～27% and fully soaking, with boiling water elder generation sucking filtration to neutral, oven dry; Extracting liquorice adds suitable quantity of water, and decocting in water 3 times extracted 2 hours at every turn, merge extractive liquid, is concentrated into 85 ℃, relative density 1.05～1.45, adds ethanol to 75%, leave standstill, incline and get supernatant, add ammonia and transfer PH8～8.5 to filter, reclaim ethanol to the thick paste shape, add the water that is equivalent to the supernatant liquid measure, slowly add hydrochloric acid to PH2～3, sedimentation and filtration, frozen water is washed 1～5 time, volatilizes naturally 1～6 hour;
(c): get xylitol and starch mix homogeneously; add the refining Indigo Naturalis of above-mentioned processing and fully stir, filter, add Radix Glycyrrhizae extractum, Fructus Chebulae's cream, artificial Calculus Bovis, Borneolum Syntheticum, Mentholum successively and make mix homogeneously; mixture is at 65～85 ℃ of heating and meltings; stir, mixing time is 5～30 minutes, insulation; at 55～75 ℃ of temperature following system, dropper bore is 1.20～3.0 millimeters; splash in 0～5 ℃ the liquid paraffin, make 1000 drop pill, promptly.
Embodiment 10
(a): get Indigo Naturalis 1g, Radix Glycyrrhizae 1g, Fructus Chebulae 1g, Mentholum 4g, Borneolum Syntheticum 1.2g, artificial Calculus Bovis 0.7g, sorbitol 24.9, arabic gum 2.4 is standby;
(b): get the Fructus Chebulae and add 30 times, 15 times moisture and got indescribably 3 hours, 2 hours, filter, merging filtrate is condensed into cream, adds 12 times of 80～99% ethanol, 10 times of precipitate with ethanol 3 times, gets supernatant and reclaims ethanol to 85 ℃, relative density 1.05～1.15; After getting hydrochloric acid that Indigo Naturalis adds 6 times 15～20% and fully soaking, with boiling water elder generation sucking filtration to neutral, oven dry; Extracting liquorice adds suitable quantity of water, and decocting in water 4 times extracted 4 hours at every turn, merge extractive liquid, is concentrated into 85 ℃, relative density 1.05～1.15, adds ethanol to 75%, leave standstill, incline and get supernatant, add ammonia and transfer PH8～8.5 to filter, reclaim ethanol to the thick paste shape, add the water that is equivalent to the supernatant liquid measure, slowly add hydrochloric acid to PH2～3, sedimentation and filtration, frozen water is washed 5 times, volatilizes naturally 6 hours;
(c): get sorbitol and Arabic evenly mixed; add the refining Indigo Naturalis of above-mentioned processing and fully stirred 5 minutes, filter, add Radix Glycyrrhizae extractum, Fructus Chebulae's cream, artificial Calculus Bovis, Borneolum Syntheticum, Mentholum successively and make mix homogeneously; mixture is at 75～115 ℃ of heating and meltings; stir, mixing time is 10～20 minutes, insulation; at 75～95 ℃ of temperature following system, dropper bore is 1.15～2.35 millimeters; splash in 5～15 ℃ the liquid paraffin, make 1000 drop pill, promptly.
Embodiment 11
(a): get Indigo Naturalis 3.33g, Radix Glycyrrhizae 3.33g, Fructus Chebulae 2.67g, Mentholum 2.67g, Borneolum Syntheticum 0.67g, artificial Calculus Bovis 0.4g, xylitol 10g, starch 2.8g are standby;
(b): get the Fructus Chebulae and add 20 times, 10 times moisture and got indescribably 1.5 hours, 1 hour, filter, merging filtrate is condensed into 1: 2 cream, adds 8 times of 95% ethanol, 5 times of precipitate with ethanol 2 times, gets supernatant and reclaims ethanol to 85 ℃, relative density 1.2～1.25; After getting hydrochloric acid that Indigo Naturalis adds 4 times 18% and fully soaking, with boiling water elder generation sucking filtration to neutral, oven dry; Extracting liquorice adds suitable quantity of water, decocting in water 3 times, and this extracted 2 hours, merge extractive liquid, is concentrated at 85 ℃, relative density 1.18～1.23 and adds ethanol to 75%, leaves standstill, incline and get supernatant, add ammonia and transfer PH8～8.5 to filter, reclaim ethanol, add the water that is equivalent to the supernatant liquid measure to paste, slowly add hydrochloric acid PH2～3, sedimentation and filtration, frozen water are washed 2～3 times, volatilize naturally 2～3 hours;
(c): the mixture of getting xylitol and starch adds the refining Indigo Naturalis of above-mentioned processing and fully stirred 10 minutes; filter; add Radix Glycyrrhizae extractum, Fructus Chebulae's cream, artificial Calculus Bovis, Borneolum Syntheticum, Mentholum successively and make mix homogeneously, mixture stirs at 45～115 ℃ of heating and meltings; mixing time is 1～120 minute; insulation is 1.0～4.0 millimeters at 45～95 ℃ of temperature following system, dropper bore, splashes in 5～8 the liquid paraffin; make drop pill, promptly.
Embodiment 12
(a): get Indigo Naturalis 3.33g, Radix Glycyrrhizae 3.33g, Fructus Chebulae 2.67g, Mentholum 2.67g, Borneolum Syntheticum 0.67g, artificial Calculus Bovis 0.4g, lactose 18g, starch 3g are standby;
(b): get the Fructus Chebulae and add 20 times, 10 times moisture and got indescribably 1.5 hours, 1 hour, filter, merging filtrate is condensed into 1: 2 cream, adds 8 times of 95% ethanol, 5 times of precipitate with ethanol 2 times, gets supernatant and reclaims ethanol to 85 ℃, relative density 1.2～1.25; After getting hydrochloric acid that Indigo Naturalis adds 4 times 18% and fully soaking, with boiling water elder generation sucking filtration to neutral, oven dry; Extracting liquorice adds suitable quantity of water, decocting in water 3 times, and this extracted 2 hours, merge extractive liquid, is concentrated at 85 ℃, relative density 1.18～1.23 and adds ethanol to 75%, leaves standstill, incline and get supernatant, add ammonia and transfer PH8～8.5 to filter, reclaim ethanol, add the water that is equivalent to the supernatant liquid measure to paste, slowly add hydrochloric acid PH2～3, sedimentation and filtration, frozen water are washed 2～3 times, volatilize naturally 2～3 hours;
(c): the mixture of getting lactose and starch adds the refining Indigo Naturalis of above-mentioned processing and fully stirred 15 minutes; filter; add Radix Glycyrrhizae extractum, Fructus Chebulae's cream, artificial Calculus Bovis, Borneolum Syntheticum, Mentholum successively and make mix homogeneously; mixture is at 60～85 ℃ of heating and meltings; stir; mixing time is 10～30 minutes; insulation; at 60～85 ℃ of temperature following system, dropper bore is 1.11～2.5 millimeters; splash in 0～18 ℃ the methyl-silicone oil, to the greatest extent and wipe liquid coolant, back packing to be dried the drop pill drop that forms; make drop pill, promptly.
Embodiment 13
(a): get Indigo Naturalis 3.33g, Radix Glycyrrhizae 3.33g, Fructus Chebulae 2.67g, Mentholum 2.67g, Borneolum Syntheticum 0.67g, artificial Calculus Bovis 0.4g, xylitol 20g, arabic gum 6.5g are standby;
(b): get the Fructus Chebulae and add 20 times, 10 times moisture and got indescribably 1.5 hours, 1 hour, filter, merging filtrate is condensed into 1: 2 cream, adds 8 times of 95% ethanol, 5 times of precipitate with ethanol 2 times, gets supernatant and reclaims ethanol to 85 ℃, relative density 1.2～1.25; After getting hydrochloric acid that Indigo Naturalis adds 4 times 18% and fully soaking, with boiling water elder generation sucking filtration to neutral, oven dry; Extracting liquorice adds suitable quantity of water, decocting in water 3 times, and this extracted 2 hours, merge extractive liquid, is concentrated at 85 ℃, relative density 1.18～1.23 and adds ethanol to 75%, leaves standstill, incline and get supernatant, add ammonia and transfer PH8～8.5 to filter, reclaim ethanol, add the water that is equivalent to the supernatant liquid measure to paste, slowly add hydrochloric acid PH2～3, sedimentation and filtration, frozen water are washed 2～3 times, volatilize naturally 2～3 hours;
(c): the mixture of getting xylitol and arabic gum adds the refining Indigo Naturalis of above-mentioned processing and fully stirred 3 minutes; filter; add Radix Glycyrrhizae extractum, Fructus Chebulae's cream, artificial Calculus Bovis, Borneolum Syntheticum, Mentholum successively and make mix homogeneously; mixture is at 60～85 ℃ of heating and meltings; stir; mixing time is 10～30 minutes; insulation; at 60～85 ℃ of temperature following system, dropper bore is 1.21～3.5 millimeters; splash in 0～10 ℃ the methyl-silicone oil, to the greatest extent and wipe liquid coolant, back packing to be dried the drop pill drop that forms; make drop pill, promptly.
Embodiment 14
(a): get Indigo Naturalis 3.33g, Radix Glycyrrhizae 3.33g, Fructus Chebulae 2.67g, Mentholum 2.67g, Borneolum Syntheticum 0.67g, artificial Calculus Bovis 0.4g, xylitol 35g, starch 8g, erythritol 6g is standby;
(b): get the Fructus Chebulae and add 20 times, 10 times moisture and got indescribably 1.5 hours, 1 hour, filter, merging filtrate is condensed into 1: 2 cream, adds 8 times of 95% ethanol, 5 times of precipitate with ethanol 2 times, gets supernatant and reclaims ethanol to 85 ℃, relative density 1.2～1.25; After getting hydrochloric acid that Indigo Naturalis adds 4 times 18% and fully soaking, with boiling water elder generation sucking filtration to neutral, oven dry; Extracting liquorice adds suitable quantity of water, decocting in water 3 times, and this extracted 2 hours, merge extractive liquid, is concentrated at 85 ℃, relative density 1.18～1.23 and adds ethanol to 75%, leaves standstill, incline and get supernatant, add ammonia and transfer PH8～8.5 to filter, reclaim ethanol, add the water that is equivalent to the supernatant liquid measure to paste, slowly add hydrochloric acid PH2～3, sedimentation and filtration, frozen water are washed 2～3 times, volatilize naturally 2～3 hours;
(c): it is evenly mixed to get xylitol, starch and erythritol; adding the refining Indigo Naturalis of above-mentioned processing fully stirred 10 minutes; filter; add Radix Glycyrrhizae extractum, Fructus Chebulae's cream, artificial Calculus Bovis, Borneolum Syntheticum, Mentholum successively and make mix homogeneously; mixture is at 60～65 ℃ of heating and meltings; stir; mixing time is 10～30 minutes; insulation is 1.21～3.5 millimeters at 60～65 ℃ of temperature following system, dropper bore, splashes in 0～5 ℃ the liquid paraffin, methyl-silicone oil; liquid coolant is use up and wiped to the drop pill drop that forms; back packing to be dried is made 1000 drop pill, promptly.
Embodiment 15
(a): get Indigo Naturalis 3.33g, Radix Glycyrrhizae 3.33g, Fructus Chebulae 2.67g, Mentholum 2.67g, Borneolum Syntheticum 0.67g, artificial Calculus Bovis 0.4g, xylitol 15g, arabic gum 4g, trehalose 3g is standby;
(b): get the Fructus Chebulae and add 20 times, 10 times moisture and got indescribably 1.5 hours, 1 hour, filter, merging filtrate is condensed into 1: 2 cream, adds 8 times of 95% ethanol, 5 times of precipitate with ethanol 2 times, gets supernatant and reclaims ethanol to 85 ℃, relative density 1.2～1.25; After getting hydrochloric acid that Indigo Naturalis adds 4 times 18% and fully soaking, with boiling water elder generation sucking filtration to neutral, oven dry; Extracting liquorice adds suitable quantity of water, decocting in water 3 times, and this extracted 2 hours, merge extractive liquid, is concentrated at 85 ℃, relative density 1.18～1.23 and adds ethanol to 75%, leaves standstill, incline and get supernatant, add ammonia and transfer PH8～8.5 to filter, reclaim ethanol, add the water that is equivalent to the supernatant liquid measure to paste, slowly add hydrochloric acid PH2～3, sedimentation and filtration, frozen water are washed 2～3 times, volatilize naturally 2～3 hours;
(c): get xylitol, trehalose and arabic gum mix homogeneously; adding the refining Indigo Naturalis of above-mentioned processing fully stirred 8 minutes; filter; add Radix Glycyrrhizae extractum, Fructus Chebulae's cream, artificial Calculus Bovis, Borneolum Syntheticum, Mentholum successively and make mix homogeneously; mixture is at 64 ℃ of heating and meltings; stir; mixing time is 10～30 minutes; insulation is 1.2～2.5 millimeters at 64 ℃ of temperature following system, dropper bore, splashes in 0 ℃ the methyl-silicone oil; liquid coolant is use up and wiped to the drop pill drop that forms; back packing to be dried is made drop pill, promptly.
Embodiment 16
(a): get Indigo Naturalis 2g, Radix Glycyrrhizae 2g, Fructus Chebulae 2g, Mentholum 3g, Borneolum Syntheticum 0.34g, artificial Calculus Bovis 0.3g, sorbitol 35g, cyclodextrin 3g, hydroxypropyl emthylcellulose 4g is standby;
(b): get the Fructus Chebulae and add 15 times, 8 times moisture and got indescribably 1.5 hours, 1 hour, filter, merging filtrate is condensed into cream, adds 8 times of 90～95% ethanol, 5 times of precipitate with ethanol 2 times, gets supernatant and reclaims ethanol to 85 ℃, relative density 1.15～1.30; After getting hydrochloric acid that Indigo Naturalis adds 4 times 18% and fully soaking, with boiling water elder generation sucking filtration to neutral, oven dry; Extracting liquorice adds suitable quantity of water, and decocting in water 3 times extracted 2.5 hours at every turn, merge extractive liquid, is concentrated into 85 ℃, relative density 1.15～1.30, adds ethanol to 75%, leave standstill, incline and get supernatant, add ammonia and transfer PH8～8.5 to filter, reclaim ethanol to the thick paste shape, add the water that is equivalent to the supernatant liquid measure, slowly add hydrochloric acid to PH2～3, sedimentation and filtration, frozen water is washed 2～3 times, volatilizes naturally 2～3 hours;
(c): get sorbitol, cyclodextrin, hydroxypropyl methylcellulose mixtures and add the refining Indigo Naturalis of above-mentioned processing and fully stirred 5～20 minutes; filter; add Radix Glycyrrhizae extractum, Fructus Chebulae's cream, artificial Calculus Bovis, Borneolum Syntheticum, Mentholum successively and make mix homogeneously; mixture is at 64 ℃ of heating and meltings; stir; mixing time is 10～30 minutes; insulation; at 64 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters; splash in 0 ℃ the methyl-silicone oil, to the greatest extent and wipe liquid coolant, back packing to be dried the drop pill drop that forms; make drop pill, promptly.
Embodiment 17
(a): get Indigo Naturalis 4g, Radix Glycyrrhizae 4g, Fructus Chebulae 2g, Mentholum 2g, Borneolum Syntheticum 0.8g, artificial Calculus Bovis 0.5g, trehalose 12g, pregelatinized Starch 3g, xanthan gum 3g is standby;
(b): get the Fructus Chebulae and add 20 times, 12 times moisture and got indescribably 2 hours, 1.5 hours, filter, merging filtrate is condensed into cream, adds 10 times of 90～95% ethanol, 5 times of precipitate with ethanol 2 times, gets supernatant and reclaims ethanol to 85 ℃, relative density 1.15～1.30; After getting hydrochloric acid that Indigo Naturalis adds 4 times 15～20% and fully soaking, with boiling water elder generation sucking filtration to neutral, oven dry; Extracting liquorice adds suitable quantity of water, and decocting in water 3 times extracted 2 hours at every turn, merge extractive liquid, is concentrated into 85 ℃, relative density 1.15～1.30, adds ethanol to 75%, leave standstill, incline and get supernatant, add ammonia and transfer PH8～8.5 to filter, reclaim ethanol to the thick paste shape, add the water that is equivalent to the supernatant liquid measure, slowly add hydrochloric acid to PH2～3, sedimentation and filtration, frozen water is washed 2～3 times, volatilizes naturally 2 hours;
(c): get trehalose, pregelatinized Starch, xanthan gum mix homogeneously; adding the refining Indigo Naturalis of above-mentioned processing fully stirred 5～20 minutes; filter; add Radix Glycyrrhizae extractum, Fructus Chebulae's cream, artificial Calculus Bovis, Borneolum Syntheticum, Mentholum successively and make mix homogeneously; mixture is at 64 ℃ of heating and meltings; stir; mixing time is 10～30 minutes; insulation is 1.2～2.5 millimeters at 64 ℃ of temperature following system, dropper bore, splashes in 0 ℃ the methyl-silicone oil; make 1000 drop pill; liquid coolant is use up and wiped to the drop pill drop that forms, back packing to be dried, promptly.
Embodiment 18
(a): get Indigo Naturalis 3g, Radix Glycyrrhizae 3g, Fructus Chebulae 2g, Mentholum 2.8g, Borneolum Syntheticum 0.6g, artificial Calculus Bovis 0.4g, sorbitol 7g, xylitol 6g, lactose 3g, chitin 1g are standby;
(b): get the Fructus Chebulae and add 18 times, 9 times moisture and got indescribably 1.5 hours, 1 hour, filter, merging filtrate is condensed into cream, adds 7 times of 90～92% ethanol, 5 times of precipitate with ethanol 2 times, gets supernatant and reclaims ethanol to 85 ℃, relative density 1.15～1.30; After getting hydrochloric acid that Indigo Naturalis adds 2 times 17～19% and fully soaking, with boiling water elder generation sucking filtration to neutral, oven dry; Extracting liquorice adds suitable quantity of water, and decocting in water 3 times extracted 2.5 hours at every turn, merge extractive liquid, is concentrated into 85 ℃, relative density 1.15～1.30, adds ethanol to 75%, leave standstill, incline and get supernatant, add ammonia and transfer PH8～8.5 to filter, reclaim ethanol to the thick paste shape, add the water that is equivalent to the supernatant liquid measure, slowly add hydrochloric acid to PH2～3, sedimentation and filtration, frozen water is washed 2～3 times, volatilizes naturally 3 hours;
(c): get sorbitol, xylitol, lactose, chitin mix homogeneously; adding the refining Indigo Naturalis of above-mentioned processing fully stirred 5～20 minutes; filter; add Radix Glycyrrhizae extractum, Fructus Chebulae's cream, artificial Calculus Bovis, Borneolum Syntheticum, Mentholum successively and make mix homogeneously; mixture is at 64 ℃ of heating and meltings; stir; mixing time is 10～30 minutes; insulation is 1.2～2.5 millimeters at 64 ℃ of temperature following system, dropper bore, splashes in 0 ℃ the methyl-silicone oil; make 1000 drop pill; liquid coolant is use up and wiped to the drop pill drop that forms, back packing to be dried, promptly.
Embodiment 19
(a): get Indigo Naturalis 5g, Radix Glycyrrhizae 1g, Fructus Chebulae 1g, Mentholum 4g, Borneolum Syntheticum 0.2g, artificial Calculus Bovis 0.7g, lactose 22g, carrageenan 4g are standby;
(b): get the Fructus Chebulae and add 25 times, 12 times moisture and got indescribably 2.5 hours, 1.5 hours, filter, merging filtrate is condensed into cream, adds 8 times of 80～90% ethanol, 6 times of precipitate with ethanol 2 times, gets supernatant and reclaims ethanol to 85 ℃, relative density 1.05～1.45; After getting hydrochloric acid that Indigo Naturalis adds 4 times 9～27% and fully soaking, with boiling water elder generation sucking filtration to neutral, oven dry; Extracting liquorice adds suitable quantity of water, and decocting in water 3 times extracted 2 hours at every turn, merge extractive liquid, is concentrated into 85 ℃, relative density 1.05～1.45, adds ethanol to 75%, leave standstill, incline and get supernatant, add ammonia and transfer PH8～8.5 to filter, reclaim ethanol to the thick paste shape, add the water that is equivalent to the supernatant liquid measure, slowly add hydrochloric acid to PH2～3, sedimentation and filtration, frozen water is washed 1～5 time, volatilizes naturally 1～6 hour;
(c): get lactose and carrageenan mix homogeneously; adding the refining Indigo Naturalis of above-mentioned processing fully stirs; filter; add Radix Glycyrrhizae extractum, Fructus Chebulae's cream, artificial Calculus Bovis, Borneolum Syntheticum, Mentholum successively and make mix homogeneously; mixture is at 65 ℃ of heating and meltings; stir; mixing time is 10～20 minutes; insulation is 1.21～2.5 millimeters at 65 ℃ of temperature following system, dropper bore, splashes in 0 ℃ the methyl-silicone oil; make 1000 drop pill; liquid coolant is use up and wiped to the drop pill drop that forms, back packing to be dried, promptly.
Embodiment 20
(a): get Indigo Naturalis 1g, Radix Glycyrrhizae 1g, Fructus Chebulae 1g, Mentholum 4g, Borneolum Syntheticum 1.2g, artificial Calculus Bovis 0.7g, xylitol 18g, sesbania gum 4g, standby;
(b): get the Fructus Chebulae and add 30 times, 15 times moisture and got indescribably 3 hours, 2 hours, filter, merging filtrate is condensed into cream, adds 12 times of 80～99% ethanol, 10 times of precipitate with ethanol 3 times, gets supernatant and reclaims ethanol to 85 ℃, relative density 1.05～1.15; After getting hydrochloric acid that Indigo Naturalis adds 6 times 15～20% and fully soaking, with boiling water elder generation sucking filtration to neutral, oven dry; Extracting liquorice adds suitable quantity of water, and decocting in water 4 times extracted 4 hours at every turn, merge extractive liquid, is concentrated into 85 ℃, relative density 1.05～1.15, adds ethanol to 75%, leave standstill, incline and get supernatant, add ammonia and transfer PH8～8.5 to filter, reclaim ethanol to the thick paste shape, add the water that is equivalent to the supernatant liquid measure, slowly add hydrochloric acid to PH2～3, sedimentation and filtration, frozen water is washed 5 times, volatilizes naturally 6 hours;
(c): get an amount of xylitol and sesbania gum mix homogeneously; adding the refining Indigo Naturalis of above-mentioned processing fully stirred 10 minutes; filter; add Radix Glycyrrhizae extractum, Fructus Chebulae's cream, artificial Calculus Bovis, Borneolum Syntheticum, Mentholum successively and make mix homogeneously; mixture is at 60～68 ℃ of heating and meltings; stir; mixing time is 10～30 minutes; insulation is 1.2～2.5 millimeters at 60～68 ℃ of temperature following system, dropper bore, splashes in 0 ℃ the methyl-silicone oil; make drop pill; liquid coolant is use up and wiped to the drop pill drop that forms, back packing to be dried, promptly.
Claims (12)
1, a kind of medicine for the treatment of pharyngitis, it is characterized in that it being to make by 1～5 part of Indigo Naturalis, 1～5 part in Radix Glycyrrhizae, 1～4 part of Fructus Chebulae, 1～4 part of Mentholum, 0.2～1.2 part of Borneolum Syntheticum, 0.1～0.7 part of artificial Calculus Bovis, appropriate amount of auxiliary materials, wherein adjuvant comprises filler and plasticity substrate, said filler is selected from the natural adjuvant of following one or more plant origins: erythritol, sorbitol, trehalose, xylitol, lactose, and they contain the water of crystallization chemical compound; Said plasticity substrate is selected from the natural adjuvant of following one or more plant origins: starch and derivant thereof, cellulose and derivant thereof, arabic gum, chitin, sesbania gum, carrageenan, Ficus elastica, xanthan gum, cyclodextrin; Described filler is 1: 0.1～1: 0.5 with the ratio of the weight of plasticizer.
2, the medicine of treatment pharyngitis as claimed in claim 1, it is characterized in that it is to be made by 2～4 parts of Indigo Naturaliss, 2～4 parts in Radix Glycyrrhizae, 2～3 parts of Fructus Chebulaes, 2～3 parts of Mentholums, 0.34～0.8 part of Borneolum Syntheticum, 0.3～0.5 part of artificial Calculus Bovis, appropriate amount of auxiliary materials, filler adjuvant wherein is selected from the natural adjuvant of following one or more plant origins: sorbitol, xylitol, lactose, maltose, and they contain the water of crystallization chemical compound; Plasticity substrate wherein is selected from the natural adjuvant of following one or more plant origins: pregelatinized Starch, methylcellulose, hydroxypropyl emthylcellulose, arabic gum, cyclodextrin; Described filler is 1: 0.1～1: 0.5 with the ratio of the weight of plasticizer.
3, the medicine of treatment pharyngitis as claimed in claim 2, it is characterized in that it is to be made by 3.33 parts of Indigo Naturaliss, 3.33 parts in Radix Glycyrrhizae, 2.67 parts of Fructus Chebulaes, 2.67 parts of Mentholums, 0.67 part of Borneolum Syntheticum, 0.4 part of artificial Calculus Bovis, appropriate amount of auxiliary materials, filler adjuvant wherein is selected from the natural adjuvant of following one or more plant origins: xylitol, lactose; Plasticity substrate wherein is selected from following one or more the natural adjuvant of plant origin: starch, arabic gum; Described filler is 1: 0.1～1: 0.5 with the ratio of the weight of plasticizer.
4, the medicine of treatment pharyngitis as claimed in claim 3 is characterized in that described adjuvant is xylitol and starch, and xylitol is 1: 0.2～1: 0.3 with the ratio of the weight of starch.
5, the medicine of treatment pharyngitis as claimed in claim 3 is characterized in that described adjuvant is lactose and starch, and lactose is 1: 0.2～1: 0.3 with the ratio of the weight of starch.
6, the medicine of treatment pharyngitis as claimed in claim 3 is characterized in that described adjuvant is xylitol and arabic gum, and the ratio of the weight of xylitol and arabic gum is 1: 0.2～1: 0.4.
7,, it is characterized in that the adjuvant and the ratio of the weight of extract drugs extractum are 1: 0.1～1: 1 as the medicine of claim 1,2 or 3 described treatment pharyngitis.
8,, it is characterized in that the adjuvant and the ratio of the weight of extract drugs extractum are 1: 0.1～1: 0.6 as the medicine of claim 1,2 or 3 described treatment pharyngitis.
9,, it is characterized in that the adjuvant and the ratio of the weight of extract drugs extractum are 1: 0.2～1: 0.4 as the medicine of claim 1,2 or 3 described treatment pharyngitis.
10, the preparation method of claim 1,2 or 3 described treatment pharyngitis medicines is characterized in that this method comprises the steps:
(a): it is standby to get 1～5 part of Indigo Naturalis, 1～5 part in Radix Glycyrrhizae, 1～4 part of Fructus Chebulae, 1～4 part of Mentholum, 0.2～1.2 part of Borneolum Syntheticum, 0.1～0.7 part of artificial Calculus Bovis, appropriate amount of auxiliary materials;
(b): get the Fructus Chebulae and add 10～30 times, 5～15 times moisture and got indescribably 0.5～3 hour, 0.5～2 hour, filter, merging filtrate is condensed into cream, add 4～12 times of 80～99% ethanol, 2～10 times of precipitate with ethanol 1～3 time, get supernatant and reclaim ethanol to 85 ℃, relative density 1.05～1.45; After getting hydrochloric acid that Indigo Naturalis adds 2～6 times 9～27% and fully soaking, with boiling water elder generation sucking filtration to neutral, oven dry; Extracting liquorice adds suitable quantity of water, and decocting in water 2～4 times extracted 1～4 hour at every turn, merge extractive liquid, is concentrated into 85 ℃, relative density 1.05～1.45, adds ethanol to 75%, leave standstill, incline and get supernatant, add ammonia and transfer PH8～8.5 to filter, reclaim ethanol to the thick paste shape, add the water that is equivalent to the supernatant liquid measure, slowly add hydrochloric acid to PH2～3, sedimentation and filtration, frozen water is washed 1～5 time, volatilizes naturally 1～6 hour;
(c): get an amount of substrate adjuvant and add the refining Indigo Naturalis of above-mentioned processing and fully stir; filter; add Radix Glycyrrhizae extractum, Fructus Chebulae's cream, artificial Calculus Bovis, Borneolum Syntheticum, Mentholum successively and make mix homogeneously, mixture stirs at 45～115 ℃ of heating and meltings; mixing time is 1～120 minute; insulation is 1.0～4.0 millimeters at 45～95 ℃ of temperature following system, dropper bore, splashes in-20～25 ℃ liquid paraffin, methyl-silicone oil or the vegetable oil; make drop pill, promptly.
11, the preparation method of treatment pharyngitis medicine as claimed in claim 10 is characterized in that this method comprises the steps:
(a): it is standby to get 2～4 parts of Indigo Naturaliss, 2～4 parts in Radix Glycyrrhizae, 2～3 parts of Fructus Chebulaes, 2～3 parts of Mentholums, 0.34～0.8 part of Borneolum Syntheticum, 0.3～0.5 part of artificial Calculus Bovis, appropriate amount of auxiliary materials;
(b): get the Fructus Chebulae and add 15～25 times, 8～12 times moisture and got indescribably 1～2 hour, 0.75～1.5 hour, filter, merging filtrate is condensed into cream, add 6～10 times of 90～97% ethanol, 4～6 times of precipitate with ethanol 2 times, get supernatant and reclaim ethanol to 85 ℃, relative density 1.15～1.30; After getting hydrochloric acid that Indigo Naturalis adds 3～5 times 15～20% and fully soaking, with boiling water elder generation sucking filtration to neutral, oven dry; Extracting liquorice adds suitable quantity of water, and decocting in water 3 times extracted 1.5～3.5 hours at every turn, merge extractive liquid, is concentrated into 85 ℃, relative density 1.15～1.30, adds ethanol to 75%, leave standstill, incline and get supernatant, add ammonia and transfer PH8～8.5 to filter, reclaim ethanol to the thick paste shape, add the water that is equivalent to the supernatant liquid measure, slowly add hydrochloric acid to PH2～3, sedimentation and filtration, frozen water is washed 2～3 times, volatilizes naturally 1.5～3.5 hours;
(c): get an amount of substrate adjuvant and add the refining Indigo Naturalis of above-mentioned processing and fully stirred 5～20 minutes; filter; add Radix Glycyrrhizae extractum, Fructus Chebulae's cream, artificial Calculus Bovis, Borneolum Syntheticum, Mentholum successively and make mix homogeneously; mixture is at 60～85 ℃ of heating and meltings; stir; mixing time is 10～30 minutes; insulation; at 60～85 ℃ of temperature following system, dropper bore is 1.1～3.5 millimeters; splash in 0～18 ℃ the liquid paraffin, methyl-silicone oil, to the greatest extent and wipe liquid coolant, back packing to be dried the drop pill drop that forms; make drop pill, promptly.
12, the preparation method of treatment pharyngitis medicine as claimed in claim 11 is characterized in that this method comprises the steps:
(a): it is standby to get 3.33 parts of Indigo Naturaliss, 3.33 parts in Radix Glycyrrhizae, 2.67 parts of Fructus Chebulaes, 2.67 parts of Mentholums, 0.67 part of Borneolum Syntheticum, 0.4 part of artificial Calculus Bovis;
(b): get the Fructus Chebulae and add 20 times, 10 times moisture and got indescribably 1.5 hours, 1 hour, filter, merging filtrate is condensed into 1: 2 cream, adds 8 times of 95% ethanol, 5 times of precipitate with ethanol 2 times, gets supernatant and reclaims ethanol to 85 ℃, relative density 1.2～1.25; After getting hydrochloric acid that Indigo Naturalis adds 4 times 18% and fully soaking, with boiling water elder generation sucking filtration to neutral, oven dry; Extracting liquorice adds suitable quantity of water, decocting in water 3 times, and this extracted 2 hours, merge extractive liquid, is concentrated at 85 ℃, relative density 1.18～1.23 and adds ethanol to 75%, leaves standstill, incline and get supernatant, add ammonia and transfer PH8～8.5 to filter, reclaim ethanol, add the water that is equivalent to the supernatant liquid measure to paste, slowly add hydrochloric acid PH2～3, sedimentation and filtration, frozen water are washed 2～3 times, volatilize naturally 2～3 hours;
(c): get an amount of substrate adjuvant and add the refining Indigo Naturalis of above-mentioned processing and fully stirred 10 minutes, filter, add Radix Glycyrrhizae extractum, Fructus Chebulae's cream, artificial Calculus Bovis, Borneolum Syntheticum, Mentholum successively and make mix homogeneously; mixture is at 64 ℃ of heating and meltings; stir, mixing time is 10～30 minutes, insulation; at 64 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters; splash in 0 ℃ the methyl-silicone oil, to the greatest extent and wipe liquid coolant, back packing to be dried the drop pill drop that forms; make drop pill, promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2003101073020A CN100450504C (en) | 2003-12-11 | 2003-12-11 | Medication for treating pharyngitis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2003101073020A CN100450504C (en) | 2003-12-11 | 2003-12-11 | Medication for treating pharyngitis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1626143A CN1626143A (en) | 2005-06-15 |
| CN100450504C true CN100450504C (en) | 2009-01-14 |
Family
ID=34758111
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2003101073020A Expired - Fee Related CN100450504C (en) | 2003-12-11 | 2003-12-11 | Medication for treating pharyngitis |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100450504C (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1331495C (en) * | 2005-09-27 | 2007-08-15 | 广西博科药业有限公司 | Throat-clearing lozenge |
| CN1899420B (en) * | 2006-06-30 | 2010-05-12 | 董继湘 | Medicine for treating pharyngitis and its preparing method |
| CN101194922B (en) * | 2006-12-08 | 2013-04-17 | 天士力制药集团股份有限公司 | Acesodyne medicament dropping pills and method for preparing the same |
| CN101088517B (en) * | 2007-04-29 | 2010-05-19 | 黄规律 | Process of making sweel cool health myrobalan fruit |
| CN102485241B (en) * | 2010-12-03 | 2013-12-25 | 天津中新药业集团股份有限公司第六中药厂 | Traditional Chinese medicine composition having functions of dispelling wind, clearing heat, removing toxins and benefiting throat and preparation method thereof |
| CN102485242B (en) * | 2010-12-03 | 2013-11-20 | 天津中新药业集团股份有限公司第六中药厂 | Chinese medicinal composition for dispelling wind, clearing heat, removing toxins, and benefiting throat, and preparation method thereof |
-
2003
- 2003-12-11 CN CNB2003101073020A patent/CN100450504C/en not_active Expired - Fee Related
Non-Patent Citations (5)
| Title |
|---|
| 中华人民共和国卫生部药品标准新药转正标准第十四册. 中华人和共和国卫生部药典委员会，13. 1998 中华人民共和国卫生部药品标准新药转正标准第十四册. 中华人民共和国卫生部药典委员会，13. 1998 |
| 中华人民共和国卫生部药品标准新药转正标准第十四册. 中华人和共和国卫生部药典委员会，13. 1998 * |
| 中华人民共和国卫生部药品标准新药转正标准第十四册. 中华人民共和国卫生部药典委员会，13. 1998 * |
| 中药滴丸剂工艺质量及发展前景述评. 安晔等.中医药学刊2002，第20卷第6期. 2002 |
| 中药滴丸剂工艺质量及发展前景述评. 安晔等.中医药学刊2002，第20卷第6期. 2002 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1626143A (en) | 2005-06-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN100450504C (en) | Medication for treating pharyngitis | |
| CN100421721C (en) | Medication for relieving cough and asthma | |
| CN101167770A (en) | Laryngalgia anti-inflammation traditional Chinese medicinal preparation with improved taste and preparation method thereof | |
| CN100455314C (en) | Medication for treating cough | |
| CN100563635C (en) | A kind of ageratum drop pill | |
| CN100563634C (en) | A kind of Herba Sidae Rhombifoliae soup drop pill | |
| CN1872327B (en) | Composition of medicine for treating diarrhea | |
| CN100502840C (en) | Medication for treating chronic rhinitis and nasal sinusitis | |
| CN100421684C (en) | Medication for treating coronary heart disease and angina | |
| CN1872250B (en) | Composition of medication for treating headache | |
| CN100512841C (en) | Medication for treating bronchitis | |
| CN100522144C (en) | Medication for treating bronchitis | |
| CN1872139B (en) | Drop pills for treating bronchitis | |
| CN100536830C (en) | Medication for treating cough and gasp | |
| CN100553617C (en) | A kind of medicine for the treatment of obstruction of qi in the chest and cardialgia | |
| CN100553618C (en) | A kind of medicine for the treatment of toothache | |
| CN100512824C (en) | Medication for treating headache | |
| CN100512833C (en) | Medication for treating cough | |
| CN100512832C (en) | Medication for treating ache | |
| CN100553620C (en) | A kind of medicine for the treatment of the thoracic obstruction | |
| CN100421658C (en) | Medication for treating coronary heart disease and angina | |
| CN1872050B (en) | Drop pills of silymarin, and preparation method | |
| CN1626133B (en) | Medication for treating coronary heart disease | |
| CN100536831C (en) | Medication for treating cardiovascular and cerebrovascular diseases | |
| CN101194946B (en) | Medicament for treating gastric cavity ache and method for preparing the same |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C56 | Change in the name or address of the patentee |
Owner name: TASLY PHARMACEUTICAL GROUP CO., LTD. Free format text: FORMER NAME: TIANJIN TASLY PHARMACEUTICAL CO., LTD. |
|
| CP01 | Change in the name or title of a patent holder |
Address after: 300402 Tianjin science and Technology Park of Beichen Xinyi Road Liaohe Road No. 1 white Patentee after: Tasly Pharmaceutical Group Co., Ltd. Address before: 300402 Tianjin science and Technology Park of Beichen Xinyi Road Liaohe Road No. 1 white Patentee before: Tianjin Tianshili Pharmaceutical Co., Ltd. |
|
| CP01 | Change in the name or title of a patent holder |
Address after: 300402 Tianjin science and Technology Park of Beichen Xinyi Road Liaohe Road No. 1 white Patentee after: Tasly Pharmaceutical Group Limited by Share Ltd Address before: 300402 Tianjin science and Technology Park of Beichen Xinyi Road Liaohe Road No. 1 white Patentee before: Tasly Pharmaceutical Group Co., Ltd. |
|
| CP01 | Change in the name or title of a patent holder | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20090114 Termination date: 20201211 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |