CN100421658C - Medication for treating coronary heart disease and angina - Google Patents
Medication for treating coronary heart disease and angina Download PDFInfo
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- CN100421658C CN100421658C CNB2003101073016A CN200310107301A CN100421658C CN 100421658 C CN100421658 C CN 100421658C CN B2003101073016 A CNB2003101073016 A CN B2003101073016A CN 200310107301 A CN200310107301 A CN 200310107301A CN 100421658 C CN100421658 C CN 100421658C
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- xylitol
- styrax
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Landscapes
- Medicinal Preparation (AREA)
Abstract
The present invention provides medicine for treating coronary disease, which overcomes the defects that the pure natural degree of auxiliary materials of the existing dripping pills is low, the existing common chemosynthesis auxiliary materials are not in the food additive catalogues of certain countries, and the taste of the dripping pills is poor. The medicine is a medicinal preparation with higher natural degree, stronger safety and lower toxic and side effects.
Description
Technical field
The present invention relates to field of medicaments, particularly, relating to Chinese medicine is the treatment treating coronary heart disease and angina pectoris preparation that raw material is made.
Background technology
Coronary heart disease also claims ischemic heart desease, since its sickness rate height, the mortality rate height, and the healthy of the mankind in serious harm, thereby b referred to as " the first human killers ".Angina pectoris is a coronary insufficiency, and cardiac muscle is rapid, of short duration ischemia and the caused clinical syndrome of anoxia.Angina pectoris is the coronary heart disease common sympton, be more common in more than 40 years old in, the old people, the male is more than the women.Angina pectoris usually occurs in fatigue, heavy meal, catch cold and when excited, vexed pain, squeezing pain or constriction that the right occurrence scope of metosteon is not clear, and pain is shoulder, middle finger, the third finger and little finger of toe radiation to the right.At present, it is more to be used for the treatment for the treatment of coronary heart disease and angina pectoris, though Western medicine is rapid-action, curative effect is determined, but the influence of its toxic and side effects, make the patient when curing a kind of disease, the misery that faces other be arranged, and present most of Chinese medicine preparation ubiquity curative effect instability, curative effect is low, onset is slow, consumption is many shortcoming.
The synthetic chemical substance that modern medicine is commonly used has spreaded all over each corner of human lives, chemical synthetic drug becomes the main flow of medicine, yet, appearance along with multiple difficult serious symptom miscellaneous diseases, western medical treatment presents imperfect, the human lives and the healthy reality and the up-to-date successes achieved in research have all proposed query to this situation, particularly along with the continuous appearance of chemical drugs toxic and side effects, the change of spectrum of disease and conversion of medical, make modern medicine be subjected to unprecedented challenge, and people also place hope in the application and development of traditional medicine on gradually.Advocate back to nature, pay attention to plant amedica use, hanker after traditional remedies, the trend of advocating natural drug forms, making full use of natural materials is human best selections.
At present, in the world, natural drug all has certain market, along with people increasing and the aging of population to the health requirements level of understanding, sub-health stateization, people thirst for back to nature more, the problem of utilize the high Drug therapy of pure natural degree, preventing some chemical synthetic drugs cann't be solved, so the background that exceeds its original traditional national culture has been expanded in the application of natural plant.From natural drug, seek the little and inexpensive medicine of side effect and become the target that countries in the world pharmaceutical manufacturer is chased.The European Community has carried out unified legislation to medical herbs, state medical herbs status such as Canada and Australia have legalized, U.S. government has also drafted the plant amedica management method, the compound recipe mix preparation that begins to accept natural drug is as curative, and these provide good international environment for Chinese medicine enters international medical market as curative.On the other hand, along with the quickening of global economic integration progress, particularly China becomes a full member of WTO, and Chinese Medicine market incorporates the breadth and depth of international medical big market and will further aggravate.Face the enormous impact of Asian countries's traditional medicine product such as the keen competition of powerful transnational medical group and Japan, Korea S, India, Thailand and European countries' plant amedica such as Germany, France, numerous products that China's Chinese medicine produces are owing to still can not meet the standard of international medical market and requirement and being kept outside of the door.
Expansion and human back to nature requirement along with the market global range, use the low medicine of toxic and side effects, especially pure natural medical more and more becomes people's first-selection, dropping pill formulation be a kind of have efficient, quick-acting new medicine preparations, it has overcome the shortcoming and deficiency of Chinese medicine preparation in the past, but present dropping pill formulation generally faces following problem: 1, drop pill adjuvant pure natural degree is not high: at present, drop pill substrate adjuvant mostly is synthetic, natural degree is lower, the searching of new alternative substrate adjuvant, the searching of the alternative substrate adjuvant that particularly natural degree is high and preparation technology thereof determine, it is again very difficult thing, because the required preparation condition of at present common possible natural substrates adjuvant succedaneum is very harsh, it all is to influence the key that drop pill prepares molding that adjuvant temperature and drop pill thereof drip the system condition.The too high then viscosity of adjuvant melt temperature is low, and poor plasticity is though the adjuvant melt temperature is crossed lowplastcity by force, but drop pill has shortcomings such as easily sticking ball, distortion, therefore, seek pure natural degree height, and the adjuvant that is suitable for substituting existing drop pill substrate is a very job of hardships.2, the drop pill outlet encounters problems: along with expanding economy, more and more internationalize in market, China is also just making great efforts to adapt to this trend, present Chinese medicine dripping pills preparation as health food, successful export to many countries, but also face many problems at present, because different countries is different to the approval of the selected adjuvant of Chinese medicine dropping pill formulation, especially industrial flourishing Europe, more strict to food adjuvant and medical auxiliary materials, and as the selected chemosynthesis adjuvant (as Polyethylene Glycol) of the dropping pill formulation of health food outlet not in the catalogue of some national food additive, it is very unfavorable that this moves towards the international market to the Chinese medicine dropping pill formulation, becomes the stumbling-block that Chinese medicine enters the international market, therefore, seek the new of one or more, can be particularly important, also very urgent for the substrate adjuvant that the international market is accepted.3, the shortcoming of mouthfeel and onset speed: the mouthfeel of Chinese medicine and preparation thereof is relatively poor to be the big characteristics of one, people when taking some drugs to the frightened of disagreeable taste that medicine had even be better than fear far away to disease, What is more, some patients are because can not overcome the poor taste of Chinese medicine or its preparation or abnormal smells from the patient and abandon the treatment of Chinese medicine, though can improve mouthfeel as medicine being made capsule or sugar coated tablet, reducing stimulates, but disintegration rate prolongs, be unfavorable for the rapid onset of medicine, to some disease, particularly need the disease of the rapid onset of medicine inapplicable.4, the preparation process difficulty of drop pill suitability for industrialized production: in the replacement process of dropping pill formulation adjuvant, determining of the preparation process of its suitability for industrialized production is very difficult something, as the ratio of the melt temperature of substrate adjuvant, the proportioning of dripping system temperature, adjuvant and medicine, dropper bore, condensing agent etc. all are the factors that influence drop pill, therefore, the replacement of substrate and to be suitable for suitability for industrialized production be a job consuming time, as to expend substantial contribution.
In order to change drop pill substrate adjuvant for a long time based on the situation of chemosynthesis adjuvant, it is low to solve the pure natural degree that present drop pill substrate faced, and can not satisfy more and more that people require back to nature, take low toxicity, the problem of the pure natural medical that has no side effect; Also can solve some problems that Chinese medicine preparation, particularly dropping pill formulation are run in exit procedure, strengthen the competitiveness of international market; The present invention has invented the pure Chinese medicine dripping pills preparation that a kind of toxic and side effects is low, evident in efficacy, moderate, adapt to industrialized great production by a large amount of tests and the research of preparation process.
Summary of the invention
The purpose of this invention is to provide a kind of treatment coronary heart disease, anginal medicine with the preparation of new type natural substrate adjuvant.
Another object of the present invention provides a kind of preparation method for the treatment of coronary heart disease, angina drug preparation.
The present invention is the new pharmacological action that the qi-blood relationship theory learned according to Chinese traditional medicine and modern medicine are found various institutes of Chinese materia medica, according to " symptomatic treatment in acute condition, radical treatment in chronic case; set upright based on reinforcing; " leading to " just must not hinder, " benefit " must not be detained, treating both the principal and secondary aspects of a disease.The medicine of producing according to this method has late result again, and finally reaches the healing purpose the existing short term effect of the treatment of coronary heart disease, and generation without any side effects.New medium adjuvant of the present invention is resulting by a large amount of tests, have pure natural property height, toxic and side effects little, take that mouthfeel is good, the acceptant characteristics of patient, be the direction of following substrate adjuvant development.The selected substrate adjuvant of the present invention is resulting by a large amount of tests, it is little to have molecular weight, soluble in water, and molten diffusing speed is faster, pure natural degree height, toxic and side effects is lower, and can reduce the medicine irritation abnormal smells from the patient, has the oral cavity of improvement acid-base value during the buccal of oral cavity, improve the characteristics of oral cavity smell, the used substrate adjuvant of the present invention is the agent of food sedan-chair flavor, takes that mouthfeel is good, the acceptant characteristics of patient, is the direction of following substrate adjuvant development.
The consumption of drug component of the present invention and the selection of adjuvant thereof also grope to sum up to draw through the inventor in a large number, each amounts of components all has curative effect preferably in following ranges: 1～50 part of Styrax part, 1～50 part of Borneolum Syntheticum, appropriate amount of auxiliary materials is made, wherein adjuvant comprises filler and plasticity substrate, said filler is selected from the natural adjuvant of following one or more plant origins: erythritol, sorbitol, fructose, D-ribonic acid-gamma lactone, arabitol, trehalose, D-ribose, low melting-point agarose, Lac, xylitol, Raffinose, glucose, malic acid, citric acid, isomalt, lactose, maltose etc., and they contain the water of crystallization chemical compound; Said plasticity substrate is selected from the natural adjuvant of following one or more plant origins: starch and derivant thereof, cellulose and derivant thereof, arabic gum, dextran, chitin, sesbania gum, carrageenan, Ficus elastica, Furcellaran, tragakanta, carrageenin, tamarind gum, pectin, xanthan gum, alginic acid and salt thereof, dextrin, cyclodextrin, agar, lactose; Described starch and derivant thereof such as pregelatinized Starch, modified starch, hydroxypropyl starch, carboxymethyl starch, described cellulose and derivant thereof such as methylcellulose, microcrystalline Cellulose, sodium carboxymethyl cellulose, hydroxypropyl emthylcellulose, cross-linking sodium carboxymethyl cellulose, hydroxyethylmethyl-cellulose, hydroxyethyl-cellulose, hydroxypropyl cellulose; Be chosen as 2～20 parts of Styrax parts, 2～20 parts of Borneolum Syntheticums, appropriate amount of auxiliary materials of preferred drug component consumption of the present invention and adjuvant thereof are made, filler adjuvant wherein is selected from following one or more the natural adjuvant of plant origin: sorbitol, xylitol, lactose, maltose, and they contain the water of crystallization chemical compound; Plasticity substrate wherein is selected from following one or more the natural adjuvant of plant origin: pregelatinized Starch, carboxymethyl starch, methylcellulose, sodium carboxymethyl cellulose, hydroxypropyl emthylcellulose, arabic gum, alginic acid, dextrin, cyclodextrin, agar, lactose; Be chosen as 5 parts of Styrax parts, 2 parts of Borneolum Syntheticums, appropriate amount of auxiliary materials of best drug component consumption of the present invention and adjuvant thereof are made, and filler adjuvant wherein is selected from following one or more the natural adjuvant of plant origin: xylitol, lactose; Plasticity substrate wherein is selected from following one or more the natural adjuvant of plant origin: starch, arabic gum.
Can also contain chemosynthesis adjuvant and animal origin adjuvant in the above-mentioned dressing, wherein filler comprises phenylglycol, hexadecanol, octadecanol, sodium stearate, tristerin, tripalmitin, carbamide, polyoxyethylene monostearate, polyoxyethylene alkyl ether; Wherein plasticity substrate comprises polyvinylpyrrolidone, crospolyvinylpyrrolidone, carbomer, polyvinyl alcohol, acrylic resin, poloxamer, gelatin.
In screening to above adjuvant, we find: plant colloid such as carrageenan, the tragakanta, pectin, agar, arabic gum, Ficus elastica, tamarind gum, locust bean gum, Pseudobulbus Bletillae (Rhizoma Bletillae) glue, guar gum, Konjac glucomannan, it is big that plant colloids such as POLY-karaya have viscosity, mobile poor, characteristics such as do not solidify after the condensation, and arabic gum has high dense low sticking character, can be mixed with the aqueous solution of 50% concentration and still have flowability, this is one of not available characteristics of other hydrophilic colloid, arabic gum has at high temperature, under the low concentration, can ooze, but not condensation, at low temperature, under the high concentration, be difficult for oozing, but characteristics such as energy condensation.Polysaccharide such as polysaccharide such as starch and derivant thereof (as gelling starch, carboxymethyl starch etc.), cellulose derivative (as methylcellulose, sodium carboxymethyl cellulose, hydroxypropyl emthylcellulose etc.), alginic acid, dextrin, cyclodextrin, lactose, in screening, find alginic acid have viscosity big, be the fruit jelly sample, dextrin has the colloid sample, characteristics such as lactose coagulability difference; And starch and derivant thereof are materials commonly used in the medical science adjuvant, thus in polysaccharide preferred starch and derivant thereof.Polyhydric alcohol such as sorbitol (88～102 ℃), xylitol (88～94.5 ℃), lactose (70～80 ℃), mannitol (166～169 ℃), maltose alcohol (135～140 ℃), isomalt polyhydric alcohol such as (98～103 ℃) screen, and find that it has following characteristics as drop pill substrate: sorbitol, lactose, isomalt are mobile poor; Mannitol, maltose alcohol fusing point are too high; The xylitol coagulability is poor slightly.After Preliminary screening, preferred xylitol, lactose, sorbitol in the selection of polyhydric alcohol, the best is an xylitol.Xylitol has following characteristics as drop pill substrate: in the time of 91 ℃, molten condition has appearred in xylitol, but not fusion fully, cooling rapidly, it separates out crystallization very soon, xylitol mixes the back good fluidity with extractum at certain proportion, can drip and can condensation, but be condensed into Powdered thing, loosely organized, the toughness extreme difference, that pinches is promptly broken.Organic acid and salt, alkali such as citric acid (100 ℃), sorbic acid (133 ℃), succinic acid (181～189 ℃), sodium acetate organic acid such as (58 ℃) and salt, alkali, its as drop pill substrate have fusing point too high, with Chinese medical concrete can't mixing etc. shortcoming.
Because of above single adjuvant existing shortcoming in as the drop pill preparation process, particularly we by above-mentioned Preliminary screening after, determine two kinds of adjuvants are used and screen: mainly be that above various adjuvants are carried out combined sorting, final determine following several: the plant colloid cooperates with the plant colloid, the cooperating of polyhydric alcohol and polyhydric alcohol, polyhydric alcohol and plant colloidally cooperate, the cooperating of the cooperating of xylitol and arabic gum, lactose and arabic gum, based on the composite auxiliary material of xylitol.Find preferred the cooperation to be xylitol, lactose and the compound use of other adjuvant, this kind combination has following characteristics: make up with mannitol: can drip not condensation; Make up with sorbic acid: both do not dissolve each other; Make up with lactose: can drip the energy condensation, but frangible; Make up with pomelo-pectin, tragakanta, sodium alginate: viscosity is big, can't drip; Make up with arabic gum: can drip, coagulability is poor slightly; Make up with dextrin: can drip, coagulability is poor slightly; Make up with starch: can drip, coagulability is also better.Determine that at last best of breed is that xylitol cooperates with arabic gum with starch, xylitol with starch, lactose.
At xylitol and starch, lactose and starch, in the research of xylitol and arabic gum combination, xylitol and starch Application of composite being prepared some required in the process of drop pill factors investigated, mainly is to the xylitol type, condensed fluid, condensate temperature influences the drop pill mouldability, xylitol and starch proportion influence mouldability, temperature is to the influence of drop pill mouldability, the extractum amount influences the drop pill mouldability, mixing time influences the drop pill mouldability, the dropper bore is to the influence of drop pill particle diameter, the formulation optimization of drop pill, the Preliminary Determination of drop pill, dissolve scattered time limit is investigated.Find that the solid xylitol has three types of powder, granular and crystallinity, and the easiest fusion of powder xylitol, again can fine dissolving be dispersed in the mixed liquor that starch, extractum forms, good fluidity, drippage is easy, and granular and crystalline xyhose alcohol is difficult for fusion, solubility property is also slightly poor, the mix flow that they and starch, extractum form is relatively poor, viscosity is very big, almost cannot drip, and therefore drips first-selected powder xylitol in the system process at drop pill.
At ratio of adjuvant molding is found in the sex research, in the combination of xylitol and starch, lactose and starch, xylitol and arabic gum, low melting point substrate adjuvant is 1: 0～1: 1.5 with the ratio of the weight of plasticity substrate adjuvant, be preferably 1: 0.1～1: 0.9, the best is 1: 0.1～1: 0.5.Low melting point substrate adjuvant of being formed within this scope and plasticity substrate adjuvant, the drug matrices fused solution all can ooze, and can condensation.Specific to each combination, xylitol is preferably 1: 0.2 with the ratio of the weight of starch～1: 0.3, and lactose is preferably 1: 0.2 with the ratio of the weight of starch～1: 0.3, and the ratio of the weight of xylitol and arabic gum is preferably 1: 0.2～and 1: 0.4.Find that in the research of temperature temperature is big especially to the influence of drop pill mouldability to the influence of drop pill mouldability, when temperature is too low, owing to the too big effect that oozes that influences drop pill of viscosity of substrate, when temperature is too high, not condensation of drop pill.Find that mixing time can have influence on the mouldability of drop pill in mixing time in to the sex research of drop pill molding, mixing time is too short, and mobile poor, influence oozes, and mixing time is oversize, influences the condensation of drop pill.Dripping under the system temperature, mixing time in 1～120 minute all can, suitable mixing time was at 10～30 minutes.Consider that mixing time can not be too short in the suitability for industrialized production, adopt the method that low temperature stirs for a long time, high temperature drips system.Find that in the research of dropper bore to the influence of drop pill particle diameter the dropper bore influences the size of drop pill and the flowability of fusion substrate, the system effect is dripped in influence.Drop pill diminishes and diminishes along with bore, but after 1.4 millimeters, along with the bore change of size that diminishes is not obvious, but the matrix flow reduction, system is dripped in influence.
So in the preparation method of preparation, medicine mixes mixing time with the substrate adjuvant be 10～30 minutes; The mixed heating and melting temperature of medicine and substrate adjuvant is 45～115 ℃, dripping the system temperature is 45～95 ℃, and liquid coolant is liquid paraffin, methyl-silicone oil or vegetable oil (Oleum Glycines, Semen Ricini wet goods), and the temperature of liquid coolant is-20～25 ℃, dropper mouth internal diameter is 1.0～4.0 millimeters; Preferred heating and melting temperature is 60～85 ℃, and dripping a system temperature is 60～85 ℃, and condensing agent is liquid paraffin, methyl-silicone oil, and the condensing agent temperature is 0～18 ℃, and the dropper bore is 1.1～3.5 millimeters, and the difference of dropper mouth external diameter and internal diameter is less for well; Best heating and melting temperature is that to make temperature be that 64 ℃, dropper bore are that 1.2～2.5 millimeters, condensing agent are 0 ℃ methyl-silicone oil to 64 ℃, droplet.
The substrate adjuvant of the best of the present invention is xylitol and starch, and xylitol is 1: 0.2～1: 0.3 with the ratio of the weight of starch; Or be lactose and starch, lactose is 1: 0.2～1: 0.3 with the ratio of the weight of starch; Or be xylitol and arabic gum, the ratio of the weight of xylitol and arabic gum is 1: 0.2～1: 0.4.
Xylitol is a kind of natural plant sweetening agent, approve through World Health Organization (WHO), xylitol is a kind of safest sweeting agent, countries in the world are extensive use of in fields such as food and oral-cavity articles, xylitol enters the help that need not insulin in the cell, when sugar utilizes obstacle, can not cause blood sugar increasing yet, can improve diabetics symptom, have the ketoplastic effect of powerful inhibition, can promote the generation of liver glycogen, directly infiltrate the Developmental and Metabolic Disorder that tissue is participated in metabolism, can be corrected protein, fat and steroid; Xylose is the internal metabolism intermediate product, and body has higher toleration to it.Clinical practice proves: the highest oral dosis tolerata can reach 220g every day, and intravenous drip every day can reach 100g.The oral 25700mg/Kg of median lethal dose(LD 50) (LD50) mice, quiet notes 6400mg/Kg, the quiet notes of rat 6200mg/Kg.
Medicine mesostroma adjuvant of the present invention and amount of drug are than can being the scope that allows on the galenic pharmacy, medicine described here can be that crude drug also can be the effective ingredient extract, in order to adapt to industrialized great production, the ratio range of mesostroma adjuvant of the present invention and medicine refers to the weight proportion of adjuvant and extract drugs extractum, and the substrate adjuvant is 1: 0.1～1: 1 with the ratio of the weight of drug extract; Preferred substrate adjuvant is 1: 0.1～1: 0.6 with the ratio of the weight of extract drugs extractum; Best substrate adjuvant is 1: 0.2～1: 0.4 with the ratio of the extraction extractum weight of medicine.
Medicine of the present invention can adopt the preparation of Chinese medicine preparation conventional method.The preparation of effective ingredient of the present invention can be adopted following method: water extraction, decoction and alcohol sedimentation technique, extraction, infusion process, percolation, reflux extraction, continuous backflow extraction method, macroreticular resin absorbing method preparation.For example, these crude drug pulverize mix homogeneously can be made powder takes after mixing it with water; Also can be with these medicines decocting together, the condensed water decocting liquid is made oral liquid then; But, preferably adopt following technology to extract, but this can not limit protection scope of the present invention to raw material in order to make each crude drug of this medicine better bring into play drug effect.
The preparation method of medicine of the present invention is as follows:
(a) get 1～50 part of Styrax, 1～50 part of Borneolum Syntheticum is standby;
(b) in appropriate amount of auxiliary materials, add Styrax, Borneolum Syntheticum, fully mix, mixture adds standby volatile oil at 45～115 ℃ of heating and meltings, stirs, mixing time is 1～120 minute, insulation is 1.0～4.0 millimeters at 45～95 ℃ of temperature following system, dropper bore, splashes in-20～25 ℃ liquid paraffin, methyl-silicone oil or the vegetable oil, make drop pill, promptly.
Preferred manufacturing procedure comprises the following steps:
(a) get 2～20 parts of Styrax, 2～20 parts of Borneolum Syntheticums are standby;
(b) add Styrax, Borneolum Syntheticum in appropriate amount of auxiliary materials, fully mix, mixture is at 60～85 ℃ of heating and meltings, add standby volatile oil, stir, mixing time is 10～30 minutes, insulation, at 60～85 ℃ of temperature following system, dropper bore is 1.1～3.5 millimeters, splash in 0～18 ℃ the liquid paraffin, methyl-silicone oil, drip and make ball, to the greatest extent and wipe liquid coolant the drop pill drop that forms, back packing to be dried, promptly.
Best preparation method comprises the following steps:
(a) get 5 parts of Styrax, 2 parts of Borneolum Syntheticums are standby;
(b) add Styrax, Borneolum Syntheticum in appropriate amount of auxiliary materials, fully mix, mixture is at 64 ℃ of heating and meltings, add standby volatile oil again, stir, mixing time is 10～30 minutes, insulation, at 64 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splash in 0 ℃ the methyl-silicone oil, drip and make ball, to the greatest extent and wipe liquid coolant the drop pill drop that forms, back packing to be dried, promptly.
The best preparation method of medicine of the present invention is:
(a) get 5 parts of Styrax, 2 parts of parts of Borneolum Syntheticum are standby;
(b) be 1: 0.2～1: 0.3 xylitol and starch mixture to ratio an amount of, weight; Or the ratio of weight is 1: 0.2～1: 0.3 lactose and starch mixture; Or the ratio of weight is to add Styrax, Borneolum Syntheticum in 1: 0.2～1: 0.4 xylitol and the arabic gum mixture, fully mixes, and mixture is at 64 ℃ of heating and meltings, add standby volatile oil again, stir, mixing time is 10～30 minutes, insulation, at 64 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splash in 0 ℃ the methyl-silicone oil, drip and make ball, to the greatest extent and wipe liquid coolant the drop pill drop that forms, back packing to be dried, promptly.
More than form when producing and to increase or to reduce according to corresponding ratio, as large-scale production can be unit with kilogram or with the ton, small-scale production can be unit with the gram also, and weight can increase or reduce, but the crude drug material weight proportion constant rate between each composition.
More than each single medicinal material, especially adjuvant drug, messenger drug or adjuvant drug and messenger drug in forming, can be replaced by suitable Chinese medicine individually or simultaneously with the identical property of medicine, effect, it is constant to replace back Chinese medicine preparation and drug effect thereof.
Medicine of the present invention can be determined usage and dosage according to patient's situation in use, but every day 1-3 time, and every day, each crude drug consumption was as the criterion with the state-promulgated pharmacopoeia dosage, was no more than the pharmacopeia ormal weight.
The drop pill that the present invention is prepared, conventional drop pill advantage is simple as preparing except having, steady quality, can make liquid medicine solidification, convenient drug administration, efficient, quick-acting, its biggest advantage is:
1, the selected adjuvant pure natural of the present invention degree height: the substrate adjuvant that employed substrate adjuvant derives from natural plants or originates based on natural plants among the present invention, selected substrate adjuvant is xylitol and starch or lactose and starch or xylitol and arabic gum, this substrate adjuvant has pure natural degree height, toxic and side effects is low, mouthfeel is good, dissolve scattered time limit is short, rapid-action, it is a kind of new medium adjuvant, can be used for substituting present chemosynthesis adjuvant, the drop pill made from this kind adjuvant, it is low to solve the pure natural degree that present drop pill substrate faced, and more and more can not satisfy people and require back to nature, take low toxicity, the problem of the pure natural medical that has no side effect.
2, some problems in the outlet of solution Chinese medicine: medicine of the present invention also can solve Chinese medicine preparation, some problems of in exit procedure, being run into of dropping pill formulation particularly, solve because different countries, especially the European countries of industry prosperity are to the difference identification of the selected adjuvant of Chinese medicine dropping pill formulation, overcome as the selected adjuvant Polyethylene Glycol of the dropping pill formulation of the health food outlet defective in some national food additive catalogue not, improve the Chinese medicine dripping pills preparation and move towards the international market, strengthen the competitiveness of international market.
3, solve the relatively poor problem of dropping pill formulation taste and further improve drug effect speed (dissolve scattered time limit): the medicinal dropping ball made from this kind substrate adjuvant of the present invention, can improve Chinese medicine preparation, the particularly present not good shortcoming of dropping pill formulation taste, improve mouthfeel, more easy for patients to accept, and the drop pill that adopts the selected adjuvant of medicine of the present invention to make has shorter dissolve scattered time limit, making drug effect faster, is the medicine that coronary heart disease, angina pectoris, myocardial ischemia are treated in a kind of onset faster.
4, higher safety and solve some problems in the drop pill storage process: the selected substrate of the present invention is not only additive, nutrient commonly used in the food industry, and can do medicinal, but do not see that it uses as the drug matrices adjuvant, therefore, with regard to substrate, be perfectly safe, have no side effect, a large amount of evidences, the drop pill made from this adjuvant can reduce effective ingredient separating out in storage process, the sticking ball of drop pill, easy shortcomings such as moisture absorption deliquescing, but the big production of suitability for industrialized.
The present invention is under instruction of Chinese Medicine theory, preparation technology's test that process is a large amount of and pharmacology, the resulting preparation of pharmacodynamics test.The present invention is evident in efficacy, has the chest stuffiness relieving of regulating the flow of vital energy, and the effect of pain relieving is used for the treatment of diseases such as coronary heart disease, angina pectoris, myocardial ischemia, chest distress clinically.Reasonable recipe of the present invention, poisonous side effect of medicine is low, it is bigger to have overcome western medicine angina pectoris toxic and side effects, the Chinese medicine curative effect is low, flavour of a drug are many or the adjuvant toxic and side effects is big, the shortcoming of incompatibility large-scale production, is a kind of economy, material benefit, definite treatment coronary heart disease, the anginal medicine of curative effect.
In order to understand the present invention better, dissolve scattered time limit, the weight differential comparative test with Subing drop pills illustrates advantage of the present invention below.
Test example 1: dissolve scattered time limit, weight differential contrast experiment's example
In vitro tests
The present invention be that the Subing drop pills that adjuvant is made compares with the Polyethylene Glycol, by measuring index such as dissolve scattered time limit, investigate its good releasing effect; Whether by weight differential, it is ripe to investigate its preparation technology, whether is fit to suitability for industrialized production.
1. test medication: the new substrate Subing drop pills of the present invention (newly) is provided by the Jinshili Medicine Research ﹠. Development Co., Ltd., Tianjin; With the Polyethylene Glycol is the Subing drop pills (old) that adjuvant is made, and presses the reference literature preparation.
2. method and result:
Dissolve scattered time limit: by " method is measured under this item of Chinese pharmacopoeia; The ball method of double differences is different: by " method is measured under this item of Chinese pharmacopoeia.Result of the test sees Table 1.
Three batches of Subing drop pills made from the new medium adjuvant of table 1 (newly) with the polyethylene glycol 6000 be Subing drop pills (old) dissolve scattered time limit made of adjuvant, weight differential relatively
Result of the test shows, the dissolve scattered time limit of new substrate Subing drop pills is that the Subing drop pills made of adjuvant is few with the Polyethylene Glycol; Different all being controlled in the pharmacopeia prescribed limit of the ball method of double differences of new Subing drop pills.Result of the test explanation, the molten diffusing speed of the Subing drop pills made from novel adjuvant is faster, is more conducive to medicine and plays a role in the shortest time; The ball weight differential of the Subing drop pills of new substrate drop pill to the Polyethylene Glycol be the similar of the Subing drop pills made of adjuvant, the ball method of double differences is different all to be controlled in the pharmacopeia prescribed limit, the difference no difference of science of statistics illustrates the alternative present chemosynthesis adjuvant of this natural substrates adjuvant, but suitability for industrialized production.
Test example 2: the present invention with the polyethylene glycol 6000 be the sticking ball comparative observation of Subing drop pills soft durometer, drop pill that adjuvant is made
1. test medication: the new substrate Subing drop pills of the present invention (newly) is the Subing drop pills (old) that adjuvant is made with the Polyethylene Glycol.
2. method and result: three batches of the things of getting it filled are loaded in the porcelain vase respectively, and use the bottle stopper good seal.Putting it into the bottom has in the exsiccator of saturated Nacl (humidity 75%) solution, exsiccator is put into 40 ℃ of drying baker of constant temperature again, and timing sampling is observed situations such as drop pill soft durometer, the sticking ball of drop pill, the results are shown in Table 2.1, table 2.2.
Three batches in table 2.1 is that the Subing drop pills reserved sample observing that adjuvant is made compares with the polyethylene glycol 6000
Table 2.2: three batches of Subing drop pills made from the new medium adjuvant (newly) with the polyethylene glycol 6000 be Subing drop pills (old) character observation made of adjuvant relatively
Result of the test shows, the drop pill soft durometer of new substrate Subing drop pills changes and with the Polyethylene Glycol is the similar, strong slightly of the Subing drop pills made of adjuvant; The sticking ball variation of the drop pill of new substrate drop pill, firmness change and be the similar of the Subing drop pills made of adjuvant with the Polyethylene Glycol.The result of the test explanation, the sticking ball of the Subing drop pills that new and old substrate adjuvant is made changes, firmness change is similar, and the alternative present chemosynthesis adjuvant of this natural substrates adjuvant is described, but suitability for industrialized production.
The specific embodiment
Embodiment 1
A: get Styrax 50g, Borneolum Syntheticum 50g, 100g is standby for xylitol 400g starch;
B: to xylitol close with starch mixture in add Styrax, Borneolum Syntheticum, fully mix, mixture is at 64 ℃ of heating and meltings, add standby volatile oil again, stir, mixing time is 10～30 minutes, insulation, at 64 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splash in 0 ℃ the methyl-silicone oil, make the 600g drop pill, to the greatest extent and wipe liquid coolant the drop pill drop that forms, back packing to be dried, promptly.
Embodiment 2
A: get Styrax 50g, Borneolum Syntheticum 20g, lactose 505g, starch 195g are standby;
B: add Styrax, Borneolum Syntheticum in lactose and starch mixture, fully mix, mixture is at 60～68 ℃ of heating and meltings, add standby volatile oil again, stir, mixing time is 10～30 minutes, insulation, at 60～68 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splash in 0～8 ℃ the methyl-silicone oil, make the 770g drop pill, to the greatest extent and wipe liquid coolant the drop pill drop that forms, back packing to be dried, promptly.
Embodiment 3
A: get Styrax 50g, Borneolum Syntheticum 50g, xylitol 293g, arabic gum 40g are standby;
B: add Styrax, Borneolum Syntheticum in xylitol and arabic gum mixture, fully mix, mixture is at 62～66 ℃ of heating and meltings, add standby volatile oil again, stir, mixing time is 10～30 minutes, insulation, at 62～66 ℃ of temperature following system, dropper bore is 1.21～2.5 millimeters, splash in 0 ℃ the methyl-silicone oil, make the 433g drop pill, to the greatest extent and wipe liquid coolant the drop pill drop that forms, back packing to be dried, promptly.
Embodiment 4
A: get Styrax 50g, Borneolum Syntheticum 105g, xylitol 105g, starch 21g, alginic acid 56g is standby;
B: add Styrax, Borneolum Syntheticum in xylitol, starch and alginic acid mixture, fully mix, mixture is at 80～85 ℃ of heating and meltings, add standby volatile oil again, stir, mixing time is 5～10 minutes, insulation, at 62～68 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splash in 0～10 ℃ the methyl-silicone oil, make the 337g drop pill, to the greatest extent and wipe liquid coolant the drop pill drop that forms, back packing to be dried, promptly.
Embodiment 5
A: get Styrax 26g, Borneolum Syntheticum 50g, xylitol 510g, arabic gum 95g, chitin 105g is standby;
B: add Styrax, Borneolum Syntheticum in xylitol and arabic gum, fully mix, mixture is at 60～85 ℃ of heating and meltings, add standby volatile oil, stir, mixing time is 10～30 minutes, insulation, at 60～85 ℃ of temperature following system, dropper bore is 1.1～3.5 millimeters, splash in 0～18 ℃ the methyl-silicone oil, drip and make the 786g ball, to the greatest extent and wipe liquid coolant the drop pill drop that forms, back packing to be dried, promptly.
Embodiment 6
A: get Styrax 60g, Borneolum Syntheticum 80g, erythritol 110g, sorbitol 95g, fructose 15g, sesbania gum 65g are standby;
B: add Styrax, Borneolum Syntheticum in erythritol, sorbitol, fructose and sesbania gum mixture, fully mix, mixture is at 60～85 ℃ of heating and meltings, add standby volatile oil, stir, mixing time is 10～30 minutes, insulation, at 60～85 ℃ of temperature following system, dropper bore is 1.1～3.5 millimeters, splash in 0～18 ℃ the liquid paraffin, drip and make the 425g ball, to the greatest extent and wipe liquid coolant the drop pill drop that forms, back packing to be dried, promptly.
Embodiment 7
A: get Styrax 5g, Borneolum Syntheticum 2g, xylitol 15g, starch 3g are standby;
B: add Styrax, Borneolum Syntheticum in xylitol and starch, fully mix, mixture is at 60～85 ℃ of heating and meltings, add standby volatile oil, stir, mixing time is 10～30 minutes, insulation, at 60～85 ℃ of temperature following system, dropper bore is 1.1～3.5 millimeters, splash in 0～18 ℃ the liquid paraffin, methyl-silicone oil, drip and make 1000 balls, to the greatest extent and wipe liquid coolant the drop pill drop that forms, back packing to be dried, promptly.
Embodiment 8
A: get Styrax 20g, Borneolum Syntheticum 20g, xylitol 65g, arabic gum 12.5g are standby;
B: add Styrax, Borneolum Syntheticum in xylitol and arabic gum, fully mix, mixture is at 60～85 ℃ of heating and meltings, add standby volatile oil, stir, mixing time is 10～30 minutes, insulation, at 60～85 ℃ of temperature following system, dropper bore is 1.1～3.5 millimeters, splash in 10～18 ℃ the liquid paraffin, drip and make the 117.5g ball, to the greatest extent and wipe liquid coolant the drop pill drop that forms, back packing to be dried, promptly.
Embodiment 9
A: get Styrax 2g, Borneolum Syntheticum 2g, lactose 18.5g, D-ribose 11.5g, starch 6g are standby;
B: add Styrax, Borneolum Syntheticum in lactose, D-ribose and starch, fully mix, mixture is at 60～85 ℃ of heating and meltings, add standby volatile oil, stir, mixing time is 10～30 minutes, insulation, at 60～85 ℃ of temperature following system, dropper bore is 1.1～3.5 millimeters, splash in 5～15 ℃ the methyl-silicone oil, drip and make 1000 balls, to the greatest extent and wipe liquid coolant the drop pill drop that forms, back packing to be dried, promptly.
Embodiment 10
A: get Styrax 60g, Borneolum Syntheticum 100g, 120g is standby for xylitol 600g starch;
B: to xylitol close with starch mixture in add Styrax, Borneolum Syntheticum, fully mix, mixture is at 60～70 ℃ of heating and meltings, add standby volatile oil again, stir, mixing time is 20～30 minutes, insulation, at 60～70 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splash in 10 ℃ the methyl-silicone oil, make the 880g drop pill, to the greatest extent and wipe liquid coolant the drop pill drop that forms, back packing to be dried, promptly.
Embodiment 11
A: get Styrax 10g, Borneolum Syntheticum 8g, lactose 15.6g, starch 12.4g are standby;
B: add Styrax, Borneolum Syntheticum in lactose and starch mixture, fully mix, mixture is at 60～68 ℃ of heating and meltings, add standby volatile oil again, stir, mixing time is 10～30 minutes, insulation, at 60～68 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splash in 0～8 ℃ the methyl-silicone oil, make 1500 drop pill, to the greatest extent and wipe liquid coolant the drop pill drop that forms, back packing to be dried, promptly.
Embodiment 12
A: get Styrax 1g, Borneolum Syntheticum 9g, xylitol 20g, arabic gum 5g are standby;
B: add Styrax, Borneolum Syntheticum in xylitol and arabic gum mixture, fully mix, mixture is at 62～66 ℃ of heating and meltings, add standby volatile oil again, stir, mixing time is 10～30 minutes, insulation, at 62～66 ℃ of temperature following system, dropper bore is 1.21～2.5 millimeters, splash in 0～10 ℃ the methyl-silicone oil, make 1000 drop pill, to the greatest extent and wipe liquid coolant the drop pill drop that forms, back packing to be dried, promptly.
Embodiment 13
A: get Styrax 7.5g, Borneolum Syntheticum 1.5g,, xylitol 20.6g, starch 6.4g be standby;
B: add Styrax, Borneolum Syntheticum in xylitol, starch mixture, fully mix, mixture is at 80～85 ℃ of heating and meltings, add standby volatile oil again, stir, mixing time is 5～10 minutes, insulation, at 62～68 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splash in 0～10 ℃ the methyl-silicone oil, make 1000 drop pill, to the greatest extent and wipe liquid coolant the drop pill drop that forms, back packing to be dried, promptly.
Embodiment 14
A: get Styrax 6g, Borneolum Syntheticum 1g, xylitol 18g, arabic gum 6g, chitin 4g is standby;
B: add Styrax, Borneolum Syntheticum in xylitol and arabic gum, fully mix, mixture is at 60～85 ℃ of heating and meltings, add standby volatile oil, stir, mixing time is 10～30 minutes, insulation, at 60～85 ℃ of temperature following system, dropper bore is 1.1～3.5 millimeters, splash in 0～18 ℃ the methyl-silicone oil, make 1000 drop pill, to the greatest extent and wipe liquid coolant the drop pill drop that forms, back packing to be dried, promptly.
Embodiment 15
A: get Styrax 35g, Borneolum Syntheticum 50g, xylitol 385g, chitin 105g are standby;
B: in xylitol and chitin, add Styrax, Borneolum Syntheticum, fully mix, mixture adds standby volatile oil at 45～115 ℃ of heating and meltings, stirs, mixing time is 1～120 minute, insulation is 1.0～4.0 millimeters at 45～95 ℃ of temperature following system, dropper bore, splashes in-20～25 ℃ liquid paraffin, methyl-silicone oil or the vegetable oil, make and drip the 575g ball, promptly.
Claims (12)
1. Subing drop pills, it is characterized in that it is to be made by 1～50 part of Styrax part, 1～50 part of Borneolum Syntheticum, appropriate amount of auxiliary materials, wherein adjuvant comprises filler and plasticity substrate, and said filler is selected from the natural adjuvant of following one or more plant origins: erythritol, sorbitol, fructose, D-ribose, xylitol, lactose; Said plasticity substrate is selected from the natural adjuvant of following one or more plant origins: starch and derivant thereof, arabic gum, chitin, sesbania gum, alginic acid and salt thereof, lactose; Described filler is 1: 0.1～1: 0.9 with the ratio of the weight of plasticizer.
2. Subing drop pills as claimed in claim 1, it is characterized in that it is to be made by 2～20 parts of Styrax, 2～20 parts of Borneolum Syntheticums, appropriate amount of auxiliary materials, filler adjuvant wherein is selected from the natural adjuvant of following one or more plant origins: sorbitol, xylitol, lactose; Plasticity substrate wherein is selected from the natural adjuvant of following one or more plant origins: starch, arabic gum, alginic acid, lactose; Described filler is 1: 0.1～1: 0.5 with the ratio of the weight of plasticizer.
3. Subing drop pills as claimed in claim 1 is characterized in that it is to be made by 5 parts of Styrax, 2 parts of Borneolum Syntheticums, appropriate amount of auxiliary materials, and filler adjuvant wherein is selected from the natural adjuvant of following one or more plant origins: xylitol, lactose; Plasticity substrate wherein is selected from the natural adjuvant of following one or more plant origins: starch, arabic gum; Described filler is 1: 0.1～1: 0.5 with the ratio of the weight of plasticizer
4. Subing drop pills as claimed in claim 3 is characterized in that described adjuvant is xylitol and starch, and xylitol is 1: 0.2～1: 0.3 with the ratio of the weight of starch.
5. Subing drop pills as claimed in claim 3 is characterized in that described adjuvant is lactose and starch, and lactose is 1: 0.2～1: 0.3 with the ratio of the weight of starch.
6. Subing drop pills as claimed in claim 3 is characterized in that described adjuvant is xylitol and arabic gum, and the ratio of the weight of xylitol and arabic gum is 1: 0.2～1: 0.4.
7. as claim 1,2 or 3 described Subing drop pills, it is characterized in that the adjuvant and the ratio of the weight of extract drugs extractum are 1: 0.1～1: 1.
8. as claim 1,2 or 3 described Subing drop pills, it is characterized in that the adjuvant and the ratio of the weight of extract drugs extractum are 1: 0.1～1: 0.6.
9. as claim 1,2 or 3 described Subing drop pills, it is characterized in that the adjuvant and the ratio of the weight of extract drugs extractum are 1: 0.2～1: 0.4.
10. the preparation method of claim 1,2 or 3 described Subing drop pills is characterized in that this method comprises the steps:
(a) get 1～50 part of Styrax part, 1～50 part of Borneolum Syntheticum is standby;
(b) in appropriate amount of auxiliary materials, add Styrax, Borneolum Syntheticum, fully mix, mixture adds standby volatile oil at 45～115 ℃ of heating and meltings, stirs, mixing time is 1～120 minute, insulation is 1.0～4.0 millimeters at 45～95 ℃ of temperature following system, dropper bore, splashes in-20～25 ℃ liquid paraffin, methyl-silicone oil or the vegetable oil, make drop pill, promptly.
11. Subing drop pills preparation method as claimed in claim 10 is characterized in that this method comprises the steps:
(a) get 2～20 parts of Styrax parts, 2～20 parts of Borneolum Syntheticums are standby;
(b) add Styrax, Borneolum Syntheticum in appropriate amount of auxiliary materials, fully mix, mixture is at 60～85 ℃ of heating and meltings, add standby volatile oil, stir, mixing time is 10～30 minutes, insulation, at 60～85 ℃ of temperature following system, dropper bore is 1.1～3.5 millimeters, splash in 0～18 ℃ the liquid paraffin, methyl-silicone oil, drip and make ball, to the greatest extent and wipe liquid coolant the drop pill drop that forms, back packing to be dried, promptly.
12. the preparation method of Subing drop pills as claimed in claim 11 is characterized in that this method comprises the steps::
(a) get 5 parts of Styrax parts, 2 parts of Borneolum Syntheticums are standby;
(b) add Styrax, Borneolum Syntheticum in appropriate amount of auxiliary materials, fully mix, mixture is at 64 ℃ of heating and meltings, add standby volatile oil again, stir, mixing time is 10～30 minutes, insulation, at 64 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splash in 0 ℃ the methyl-silicone oil, drip and make ball, to the greatest extent and wipe liquid coolant the drop pill drop that forms, back packing to be dried, promptly.
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Non-Patent Citations (5)
| Title |
|---|
| 中华人民共和国卫生部药品标准中药成方制剂第十五册. 中华人民共和国卫生部药典委员会，90. 1998 中华人民共和国卫生部药品标准中药成方制剂第十五册. 中华人民共和国药典委员会，90. 1998 |
| 中华人民共和国卫生部药品标准中药成方制剂第十五册. 中华人民共和国卫生部药典委员会，90. 1998 * |
| 中华人民共和国卫生部药品标准中药成方制剂第十五册. 中华人民共和国药典委员会，90. 1998 * |
| 中药滴丸剂工艺质量及发展前景述评. 安晔等.中医药学刊2002，第20卷第6期. 2002 |
| 中药滴丸剂工艺质量及发展前景述评. 安晔等.中医药学刊2002，第20卷第6期. 2002 * |
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