CN100553619C - A kind of treatment coronary heart disease, anginal medicine - Google Patents
A kind of treatment coronary heart disease, anginal medicine Download PDFInfo
- Publication number
- CN100553619C CN100553619C CNB2003101072901A CN200310107290A CN100553619C CN 100553619 C CN100553619 C CN 100553619C CN B2003101072901 A CNB2003101072901 A CN B2003101072901A CN 200310107290 A CN200310107290 A CN 200310107290A CN 100553619 C CN100553619 C CN 100553619C
- Authority
- CN
- China
- Prior art keywords
- adjuvant
- rhizoma chuanxiong
- extraction
- treatment
- borneolum syntheticum
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000003814 drug Substances 0.000 title claims abstract description 120
- 208000029078 coronary artery disease Diseases 0.000 title claims abstract description 30
- IZEKFCXSFNUWAM-UHFFFAOYSA-N dipyridamole Chemical compound C=12N=C(N(CCO)CCO)N=C(N3CCCCC3)C2=NC(N(CCO)CCO)=NC=1N1CCCCC1 IZEKFCXSFNUWAM-UHFFFAOYSA-N 0.000 title abstract description 5
- 239000002671 adjuvant Substances 0.000 claims abstract description 130
- 239000006187 pill Substances 0.000 claims abstract description 126
- 239000000463 material Substances 0.000 claims abstract description 34
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 167
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 122
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 92
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 90
- 235000010447 xylitol Nutrition 0.000 claims description 90
- 239000000811 xylitol Substances 0.000 claims description 90
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 90
- 229960002675 xylitol Drugs 0.000 claims description 90
- 238000000605 extraction Methods 0.000 claims description 85
- 229920002472 Starch Polymers 0.000 claims description 76
- 239000008107 starch Substances 0.000 claims description 76
- 235000019698 starch Nutrition 0.000 claims description 76
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims description 75
- 239000000758 substrate Substances 0.000 claims description 68
- 238000010438 heat treatment Methods 0.000 claims description 65
- 239000000203 mixture Substances 0.000 claims description 59
- 239000000284 extract Substances 0.000 claims description 49
- 238000003756 stirring Methods 0.000 claims description 45
- 229940079593 drug Drugs 0.000 claims description 43
- 238000002156 mixing Methods 0.000 claims description 42
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 41
- 239000008101 lactose Substances 0.000 claims description 40
- 239000007788 liquid Substances 0.000 claims description 40
- 238000002360 preparation method Methods 0.000 claims description 40
- 238000002844 melting Methods 0.000 claims description 35
- 230000008018 melting Effects 0.000 claims description 35
- 238000009413 insulation Methods 0.000 claims description 34
- 238000000034 method Methods 0.000 claims description 34
- 206010002383 Angina Pectoris Diseases 0.000 claims description 31
- 235000010489 acacia gum Nutrition 0.000 claims description 29
- 239000001785 acacia senegal l. willd gum Substances 0.000 claims description 29
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims description 28
- 239000000243 solution Substances 0.000 claims description 28
- 238000010992 reflux Methods 0.000 claims description 25
- 229920002545 silicone oil Polymers 0.000 claims description 25
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 24
- 239000003795 chemical substances by application Substances 0.000 claims description 21
- 229940057995 liquid paraffin Drugs 0.000 claims description 21
- 239000002253 acid Substances 0.000 claims description 14
- 229910021529 ammonia Inorganic materials 0.000 claims description 14
- 239000002826 coolant Substances 0.000 claims description 14
- 230000006837 decompression Effects 0.000 claims description 14
- 238000004064 recycling Methods 0.000 claims description 14
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 13
- -1 tragakanta Substances 0.000 claims description 13
- 239000000945 filler Substances 0.000 claims description 11
- 235000015112 vegetable and seed oil Nutrition 0.000 claims description 11
- 239000008158 vegetable oil Substances 0.000 claims description 11
- 241001597008 Nomeidae Species 0.000 claims description 10
- 238000012856 packing Methods 0.000 claims description 10
- 230000008569 process Effects 0.000 claims description 10
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 8
- 235000010443 alginic acid Nutrition 0.000 claims description 8
- 229920000615 alginic acid Polymers 0.000 claims description 8
- 239000000783 alginic acid Substances 0.000 claims description 8
- 229960001126 alginic acid Drugs 0.000 claims description 8
- 150000004781 alginic acids Chemical class 0.000 claims description 8
- 239000000600 sorbitol Substances 0.000 claims description 8
- 229940032147 starch Drugs 0.000 claims description 8
- 229920001353 Dextrin Polymers 0.000 claims description 7
- 239000004375 Dextrin Substances 0.000 claims description 7
- 235000019425 dextrin Nutrition 0.000 claims description 7
- 239000004615 ingredient Substances 0.000 claims description 7
- 239000000843 powder Substances 0.000 claims description 7
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 claims description 6
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 6
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 claims description 6
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims description 6
- 239000002994 raw material Substances 0.000 claims description 6
- 239000001117 sulphuric acid Substances 0.000 claims description 6
- 235000011149 sulphuric acid Nutrition 0.000 claims description 6
- 229920001817 Agar Polymers 0.000 claims description 5
- 229920000858 Cyclodextrin Polymers 0.000 claims description 5
- 239000008272 agar Substances 0.000 claims description 5
- 235000010419 agar Nutrition 0.000 claims description 5
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 claims description 5
- 239000006071 cream Substances 0.000 claims description 5
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims description 5
- 229920001285 xanthan gum Polymers 0.000 claims description 5
- 235000010493 xanthan gum Nutrition 0.000 claims description 5
- 239000000230 xanthan gum Substances 0.000 claims description 5
- 229940082509 xanthan gum Drugs 0.000 claims description 5
- SERLAGPUMNYUCK-DCUALPFSSA-N 1-O-alpha-D-glucopyranosyl-D-mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O SERLAGPUMNYUCK-DCUALPFSSA-N 0.000 claims description 4
- 229920002101 Chitin Polymers 0.000 claims description 4
- 235000010980 cellulose Nutrition 0.000 claims description 4
- 229920002678 cellulose Polymers 0.000 claims description 4
- 239000001913 cellulose Substances 0.000 claims description 4
- 239000001341 hydroxy propyl starch Substances 0.000 claims description 4
- 235000013828 hydroxypropyl starch Nutrition 0.000 claims description 4
- 239000000905 isomalt Substances 0.000 claims description 4
- 235000010439 isomalt Nutrition 0.000 claims description 4
- HPIGCVXMBGOWTF-UHFFFAOYSA-N isomaltol Natural products CC(=O)C=1OC=CC=1O HPIGCVXMBGOWTF-UHFFFAOYSA-N 0.000 claims description 4
- 238000007560 sedimentation technique Methods 0.000 claims description 4
- 239000008187 granular material Substances 0.000 claims description 3
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims description 2
- HEBKCHPVOIAQTA-QWWZWVQMSA-N D-arabinitol Chemical compound OC[C@@H](O)C(O)[C@H](O)CO HEBKCHPVOIAQTA-QWWZWVQMSA-N 0.000 claims description 2
- 239000004386 Erythritol Substances 0.000 claims description 2
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 claims description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 2
- MUPFEKGTMRGPLJ-RMMQSMQOSA-N Raffinose Natural products O(C[C@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](O[C@@]2(CO)[C@H](O)[C@@H](O)[C@@H](CO)O2)O1)[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 MUPFEKGTMRGPLJ-RMMQSMQOSA-N 0.000 claims description 2
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims description 2
- MUPFEKGTMRGPLJ-UHFFFAOYSA-N UNPD196149 Natural products OC1C(O)C(CO)OC1(CO)OC1C(O)C(O)C(O)C(COC2C(C(O)C(O)C(CO)O2)O)O1 MUPFEKGTMRGPLJ-UHFFFAOYSA-N 0.000 claims description 2
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 2
- 239000002775 capsule Substances 0.000 claims description 2
- 239000008298 dragée Substances 0.000 claims description 2
- 235000019414 erythritol Nutrition 0.000 claims description 2
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 claims description 2
- 229940009714 erythritol Drugs 0.000 claims description 2
- 239000008103 glucose Substances 0.000 claims description 2
- 238000001802 infusion Methods 0.000 claims description 2
- 238000005325 percolation Methods 0.000 claims description 2
- MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 claims description 2
- 229920005989 resin Polymers 0.000 claims description 2
- 239000011347 resin Substances 0.000 claims description 2
- 239000007940 sugar coated tablet Substances 0.000 claims description 2
- 238000003809 water extraction Methods 0.000 claims description 2
- 239000004480 active ingredient Substances 0.000 claims 2
- 239000006196 drop Substances 0.000 claims 2
- 239000007924 injection Substances 0.000 claims 2
- 238000002347 injection Methods 0.000 claims 2
- 239000002674 ointment Substances 0.000 claims 2
- 239000002662 enteric coated tablet Substances 0.000 claims 1
- 239000007941 film coated tablet Substances 0.000 claims 1
- 239000007902 hard capsule Substances 0.000 claims 1
- 241000411851 herbal medicine Species 0.000 claims 1
- 239000011505 plaster Substances 0.000 claims 1
- 239000007901 soft capsule Substances 0.000 claims 1
- 239000007921 spray Substances 0.000 claims 1
- 239000000829 suppository Substances 0.000 claims 1
- 239000003826 tablet Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 24
- 231100000331 toxic Toxicity 0.000 abstract description 8
- 230000002588 toxic effect Effects 0.000 abstract description 8
- 235000013373 food additive Nutrition 0.000 abstract description 3
- 239000002778 food additive Substances 0.000 abstract description 3
- 239000000825 pharmaceutical preparation Substances 0.000 abstract description 2
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 239000000341 volatile oil Substances 0.000 description 51
- 239000009982 suxiao jiuxinwan Substances 0.000 description 22
- 241000196324 Embryophyta Species 0.000 description 20
- 239000012141 concentrate Substances 0.000 description 16
- 238000009472 formulation Methods 0.000 description 15
- 238000004519 manufacturing process Methods 0.000 description 14
- 238000012360 testing method Methods 0.000 description 13
- 239000002202 Polyethylene glycol Substances 0.000 description 12
- 229920001223 polyethylene glycol Polymers 0.000 description 12
- 238000001556 precipitation Methods 0.000 description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 11
- 201000010099 disease Diseases 0.000 description 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 10
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 10
- 229920000053 polysorbate 80 Polymers 0.000 description 10
- 238000011160 research Methods 0.000 description 10
- 239000006228 supernatant Substances 0.000 description 10
- 238000009833 condensation Methods 0.000 description 9
- 230000005494 condensation Effects 0.000 description 9
- 230000004927 fusion Effects 0.000 description 8
- 210000000214 mouth Anatomy 0.000 description 8
- 208000002193 Pain Diseases 0.000 description 6
- 210000000038 chest Anatomy 0.000 description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- 239000000084 colloidal system Substances 0.000 description 6
- 150000005846 sugar alcohols Polymers 0.000 description 6
- 206010061876 Obstruction Diseases 0.000 description 5
- 230000008859 change Effects 0.000 description 5
- 238000001035 drying Methods 0.000 description 5
- 238000005516 engineering process Methods 0.000 description 5
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 4
- 230000033228 biological regulation Effects 0.000 description 4
- 239000001768 carboxy methyl cellulose Substances 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 230000018109 developmental process Effects 0.000 description 4
- 230000000857 drug effect Effects 0.000 description 4
- 230000003203 everyday effect Effects 0.000 description 4
- 239000004744 fabric Substances 0.000 description 4
- 235000013305 food Nutrition 0.000 description 4
- 239000002932 luster Substances 0.000 description 4
- 239000006225 natural substrate Substances 0.000 description 4
- 231100000957 no side effect Toxicity 0.000 description 4
- 238000012216 screening Methods 0.000 description 4
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 4
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical group CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 3
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 3
- 229930195725 Mannitol Natural products 0.000 description 3
- 229920000881 Modified starch Polymers 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 230000017531 blood circulation Effects 0.000 description 3
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 description 3
- 235000010418 carrageenan Nutrition 0.000 description 3
- 229920001525 carrageenan Polymers 0.000 description 3
- 208000026106 cerebrovascular disease Diseases 0.000 description 3
- 229920001429 chelating resin Polymers 0.000 description 3
- 238000002425 crystallisation Methods 0.000 description 3
- 230000008025 crystallization Effects 0.000 description 3
- 229920000591 gum Polymers 0.000 description 3
- 235000013402 health food Nutrition 0.000 description 3
- 230000000302 ischemic effect Effects 0.000 description 3
- 229960001375 lactose Drugs 0.000 description 3
- 231100000053 low toxicity Toxicity 0.000 description 3
- 239000000594 mannitol Substances 0.000 description 3
- 235000010355 mannitol Nutrition 0.000 description 3
- 229920000609 methyl cellulose Polymers 0.000 description 3
- 239000001923 methylcellulose Substances 0.000 description 3
- 235000010981 methylcellulose Nutrition 0.000 description 3
- 238000000465 moulding Methods 0.000 description 3
- 230000002107 myocardial effect Effects 0.000 description 3
- 208000031225 myocardial ischemia Diseases 0.000 description 3
- 229920001277 pectin Polymers 0.000 description 3
- 239000001814 pectin Substances 0.000 description 3
- 229920001282 polysaccharide Polymers 0.000 description 3
- 239000005017 polysaccharide Substances 0.000 description 3
- 150000004804 polysaccharides Chemical class 0.000 description 3
- 230000009467 reduction Effects 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- 230000035943 smell Effects 0.000 description 3
- 235000002639 sodium chloride Nutrition 0.000 description 3
- 238000000194 supercritical-fluid extraction Methods 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 description 2
- 208000024172 Cardiovascular disease Diseases 0.000 description 2
- 206010008190 Cerebrovascular accident Diseases 0.000 description 2
- SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 description 2
- 244000286663 Ficus elastica Species 0.000 description 2
- 206010021143 Hypoxia Diseases 0.000 description 2
- 231100000111 LD50 Toxicity 0.000 description 2
- 208000006011 Stroke Diseases 0.000 description 2
- 235000004298 Tamarindus indica Nutrition 0.000 description 2
- 240000004584 Tamarindus indica Species 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- 230000002159 abnormal effect Effects 0.000 description 2
- 230000032683 aging Effects 0.000 description 2
- PYMYPHUHKUWMLA-LMVFSUKVSA-N aldehydo-D-ribose Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 description 2
- 239000003513 alkali Substances 0.000 description 2
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 description 2
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 description 2
- 239000000679 carrageenan Substances 0.000 description 2
- 229940113118 carrageenan Drugs 0.000 description 2
- 235000015165 citric acid Nutrition 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 239000002131 composite material Substances 0.000 description 2
- 210000004351 coronary vessel Anatomy 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000002526 effect on cardiovascular system Effects 0.000 description 2
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 2
- 210000000887 face Anatomy 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 235000008216 herbs Nutrition 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 208000028867 ischemia Diseases 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 235000010987 pectin Nutrition 0.000 description 2
- 208000037920 primary disease Diseases 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 230000035807 sensation Effects 0.000 description 2
- 235000019615 sensations Nutrition 0.000 description 2
- 239000004334 sorbic acid Substances 0.000 description 2
- 229940075582 sorbic acid Drugs 0.000 description 2
- 235000010199 sorbic acid Nutrition 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 2
- 235000000346 sugar Nutrition 0.000 description 2
- PVNIQBQSYATKKL-UHFFFAOYSA-N tripalmitin Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCC PVNIQBQSYATKKL-UHFFFAOYSA-N 0.000 description 2
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 2
- LUEWUZLMQUOBSB-FSKGGBMCSA-N (2s,3s,4s,5s,6r)-2-[(2r,3s,4r,5r,6s)-6-[(2r,3s,4r,5s,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5s,6r)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@@H](O[C@@H]2[C@H](O[C@@H](OC3[C@H](O[C@@H](O)[C@@H](O)[C@H]3O)CO)[C@@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O LUEWUZLMQUOBSB-FSKGGBMCSA-N 0.000 description 1
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 229920000178 Acrylic resin Polymers 0.000 description 1
- 239000004925 Acrylic resin Substances 0.000 description 1
- 229920000936 Agarose Polymers 0.000 description 1
- 244000247812 Amorphophallus rivieri Species 0.000 description 1
- 235000001206 Amorphophallus rivieri Nutrition 0.000 description 1
- 206010059245 Angiopathy Diseases 0.000 description 1
- 206010002660 Anoxia Diseases 0.000 description 1
- 241000976983 Anoxia Species 0.000 description 1
- 206010003210 Arteriosclerosis Diseases 0.000 description 1
- 208000037260 Atherosclerotic Plaque Diseases 0.000 description 1
- 206010010071 Coma Diseases 0.000 description 1
- 206010051625 Conjunctival hyperaemia Diseases 0.000 description 1
- 206010010726 Conjunctival oedema Diseases 0.000 description 1
- 206010052895 Coronary artery insufficiency Diseases 0.000 description 1
- 241000721047 Danaus plexippus Species 0.000 description 1
- 208000012239 Developmental disease Diseases 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- 206010013954 Dysphoria Diseases 0.000 description 1
- 241001411320 Eriogonum inflatum Species 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- 206010017577 Gait disturbance Diseases 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 229920002581 Glucomannan Polymers 0.000 description 1
- 229920002527 Glycogen Polymers 0.000 description 1
- 229920002907 Guar gum Polymers 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
- 229920001479 Hydroxyethyl methyl cellulose Polymers 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 229920002752 Konjac Polymers 0.000 description 1
- 229920000161 Locust bean gum Polymers 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 1
- 239000004368 Modified starch Substances 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 206010068319 Oropharyngeal pain Diseases 0.000 description 1
- 206010033557 Palpitations Diseases 0.000 description 1
- 208000031481 Pathologic Constriction Diseases 0.000 description 1
- 201000007100 Pharyngitis Diseases 0.000 description 1
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 208000034189 Sclerosis Diseases 0.000 description 1
- 244000275012 Sesbania cannabina Species 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical class [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- 206010047163 Vasospasm Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 150000005215 alkyl ethers Chemical class 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000007953 anoxia Effects 0.000 description 1
- 208000002399 aphthous stomatitis Diseases 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 235000013877 carbamide Nutrition 0.000 description 1
- 229960001631 carbomer Drugs 0.000 description 1
- 206010008118 cerebral infarction Diseases 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 208000035850 clinical syndrome Diseases 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 238000009509 drug development Methods 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 229940046240 glucomannan Drugs 0.000 description 1
- 235000001727 glucose Nutrition 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 150000002333 glycines Chemical class 0.000 description 1
- 229940096919 glycogen Drugs 0.000 description 1
- 235000010417 guar gum Nutrition 0.000 description 1
- 239000000665 guar gum Substances 0.000 description 1
- 229960002154 guar gum Drugs 0.000 description 1
- 208000019622 heart disease Diseases 0.000 description 1
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 229940071826 hydroxyethyl cellulose Drugs 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 230000001709 ictal effect Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 239000013067 intermediate product Substances 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 235000015110 jellies Nutrition 0.000 description 1
- 239000008274 jelly Substances 0.000 description 1
- 235000010485 konjac Nutrition 0.000 description 1
- 239000000252 konjac Substances 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 235000010420 locust bean gum Nutrition 0.000 description 1
- 239000000711 locust bean gum Substances 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 238000007726 management method Methods 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 208000030159 metabolic disease Diseases 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 235000019426 modified starch Nutrition 0.000 description 1
- 210000004165 myocardium Anatomy 0.000 description 1
- 231100000862 numbness Toxicity 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 230000036284 oxygen consumption Effects 0.000 description 1
- 229960000292 pectin Drugs 0.000 description 1
- 210000005259 peripheral blood Anatomy 0.000 description 1
- 239000011886 peripheral blood Substances 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 229960000502 poloxamer Drugs 0.000 description 1
- 229920001983 poloxamer Polymers 0.000 description 1
- 229940093429 polyethylene glycol 6000 Drugs 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229910052573 porcelain Inorganic materials 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000003578 releasing effect Effects 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- RYYKJJJTJZKILX-UHFFFAOYSA-M sodium octadecanoate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC([O-])=O RYYKJJJTJZKILX-UHFFFAOYSA-M 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 230000036262 stenosis Effects 0.000 description 1
- 208000037804 stenosis Diseases 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 239000001384 succinic acid Substances 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000026676 system process Effects 0.000 description 1
- 210000000115 thoracic cavity Anatomy 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 208000004371 toothache Diseases 0.000 description 1
- 229960001947 tripalmitin Drugs 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention provides a kind of coronary heart disease, anginal medicine of being used for the treatment of, the present invention overcome present drop pill adjuvant pure natural degree not high and at present the common chemical synthesis auxiliary material not in some national food additive catalogue, the relatively poor shortcoming of drop pill mouthfeel, be that a kind of natural degree is higher, the pharmaceutical preparation that safety is stronger, toxic and side effects is lower.
Description
Technical field
The present invention relates to field of medicaments, particularly, relating to Chinese medicine is treatment coronary heart disease, the anginal pharmaceutical preparation that raw material is made.
Background technology
Cardiovascular and cerebrovascular disease is to cause human first dead sick the kind, and along with the raising of social life level and the aging of population, the research of cardiovascular and cerebrovascular diseases medicament becomes the focus of drug development.Coronary heart disease is the abbreviation of coronary heart disease, be a kind of because coronary artery stationarity (atheroma sclerosis) or dynamic property (vasospasm) stenosis or occlusion, the coronary circulation obstacle takes place, cause that the myocardial oxygen pin is unbalance and cause myocardial ischemia-anoxemia or downright bad a kind of heart disease between needing, also claim ischemic heart desease.Coronary heart disease is because its sickness rate height, the mortality rate height, and serious harm human healthy, thereby b referred to as " the first human killers ".Angina pectoris is a coronary insufficiency, and cardiac muscle is rapid, of short duration ischemia and the caused clinical syndrome of anoxia.Angina pectoris is the coronary heart disease common sympton, usually occurs in fatigue, heavy meal, catches cold and when excited, and vexed pain, squeezing pain or constriction that the right occurrence scope of metosteon is not clear, patient is conscious to have palpitation, suffocates, sometimes with dying sensation.Ischemia apoplexy (cerebral infarction) all is important opportunitys of its prevention and treatment at acute attack stage and in apoplexy early stage and convalescent period.The thoracic obstruction (pained) is that Chinese medicine is understood the simplicity of angina pectoris, and the traditional Chinese medical science thinks that primary disease is the sick class disease of internal organs numbness of main performance with ambition uncomfortable in chest and ictal pain.Primary disease is equivalent to alleged coronary heart disease of modern medicine and ischemic heart desease.
At present, it is more to be used for the treatment for the treatment of coronary heart disease and angina pectoris, though Western medicine is rapid-action, curative effect is determined, but the influence of its toxic and side effects, make the patient when curing a kind of disease, the misery that faces other be arranged, and the shortcoming of present most of Chinese medicine preparation ubiquity curative effect instability, curative effect is low, onset is slow, consumption is many shortcoming.The synthetic chemical substance commonly used as modern medicine spreaded all over each corner of human lives, chemical synthetic drug becomes the main flow of medicine, yet, appearance along with multiple difficult serious symptom miscellaneous diseases, western medical treatment presents imperfect, the human lives and the healthy reality and the up-to-date successes achieved in research have all proposed query to this situation, particularly along with the continuous appearance of chemical drugs toxic and side effects, the change of spectrum of disease and conversion of medical, make modern medicine be subjected to unprecedented challenge, and people also place hope in the application and development of traditional medicine on gradually.Advocate back to nature, pay attention to plant amedica use, hanker after traditional remedies, the trend of advocating natural drug forms, making full use of natural materials is human best selections.
At present, in the world, natural drug all has certain market, along with people increasing and the aging of population to the health requirements level of understanding, sub-health stateization, people's prestige back to nature that becomes soaked with sweat more, the problem of utilize the high Drug therapy of pure natural degree, preventing some chemical synthetic drugs cann't be solved, so the background that exceeds its original traditional national culture has been expanded in the application of natural plant.From natural drug, seek the little and inexpensive medicine of side effect and become the target that countries in the world pharmaceutical manufacturer is chased.The European Community has carried out unified legislation to medical herbs, state medical herbs status such as Canada and Australia have legalized, U.S. government has also drafted the plant amedica management method, the compound recipe mix preparation that begins to accept natural drug is as curative, and these provide good international environment for Chinese medicine enters international medical market as curative.On the other hand, along with the quickening of global economic integration progress, particularly China becomes a full member of WTO, and Chinese Medicine market incorporates the breadth and depth of international medical big market and will further aggravate.Face the enormous impact of Asian countries's traditional medicine product such as the keen competition of powerful transnational medical group and Japan, Korea S, India, Thailand and European countries' plant amedica such as Germany, France, numerous products that China's Chinese medicine produces are owing to still can not meet the standard of international medical market and requirement and being kept outside of the door.
Expansion and human back to nature requirement along with the market global range, use the low medicine of toxic and side effects, especially pure natural medical more and more becomes people's first-selection, dropping pill formulation be a kind of have efficient, quick-acting new medicine preparations, it has overcome the shortcoming and deficiency of Chinese medicine preparation in the past, but present dropping pill formulation generally faces following problem: 1, drop pill adjuvant pure natural degree is not high: at present, drop pill substrate adjuvant mostly is synthetic, natural degree is lower, the searching of new alternative substrate adjuvant, the searching of the alternative substrate adjuvant that particularly natural degree is high and preparation technology thereof determine, it is again very difficult thing, because the required preparation condition of at present common possible natural substrates adjuvant succedaneum is very harsh, it all is to influence the key that drop pill prepares molding that adjuvant temperature and drop pill thereof drip the system condition.The too high then viscosity of adjuvant melt temperature is low, and poor plasticity is though the adjuvant melt temperature is crossed lowplastcity by force, but drop pill has shortcomings such as easily sticking ball, distortion, therefore, seek pure natural degree height, and the adjuvant that is suitable for substituting existing drop pill substrate is a very job of hardships.2, the dropping pill formulation outlet encounters problems: along with expanding economy, more and more internationalize in market, China is also just making great efforts to adapt to this trend, present Chinese medicine dripping pills preparation as health food, successful export to many countries, but also face many problems at present, because different countries is different to the approval of the selected adjuvant of Chinese medicine dropping pill formulation, especially industrial flourishing Europe, more strict to food adjuvant and medical auxiliary materials, and as the selected chemosynthesis adjuvant (as Polyethylene Glycol) of the dropping pill formulation of health food outlet not in the catalogue of some national food additive, it is very unfavorable that this moves towards the international market to the Chinese medicine dropping pill formulation, become the stumbling-block that Chinese medicine enters the international market, therefore, seek the new of one or more, can be particularly important, also very urgent for the substrate adjuvant that the international market is accepted.3, the shortcoming of mouthfeel and onset speed: the mouthfeel of Chinese medicine and preparation thereof is relatively poor to be the big characteristics of one, people when taking some drugs to the frightened of disagreeable taste that medicine had even be better than fear far away to disease, What is more, some patients are because can not overcome the poor taste of Chinese medicine or its preparation or abnormal smells from the patient and abandon the treatment of Chinese medicine, though can improve mouthfeel as medicine being made capsule or sugar coated tablet, reducing stimulates, but disintegration rate prolongs, be unfavorable for the rapid onset of medicine, to some disease, particularly need the disease of the rapid onset of medicine inapplicable.4, the preparation process difficulty of drop pill suitability for industrialized production: in the replacement process of dropping pill formulation adjuvant, determining of the preparation process of its suitability for industrialized production is very difficult something, as the ratio of the melt temperature of substrate adjuvant, the proportioning of dripping system temperature, adjuvant and medicine, dropper bore, condensing agent etc. all are the factors that influence drop pill, therefore, the replacement of substrate and to be suitable for suitability for industrialized production be a job consuming time, as to expend substantial contribution.
In order to change drop pill substrate adjuvant for a long time based on the situation of chemosynthesis adjuvant, it is low to solve the pure natural degree that present drop pill substrate faced, and can not satisfy more and more that people require back to nature, take low toxicity, the problem of the pure natural medical that has no side effect; Also can solve some problems that Chinese medicine preparation, particularly dropping pill formulation are run in exit procedure, strengthen the competitiveness of international market; The present invention has invented the pure Chinese medicine dripping pills preparation that a kind of toxic and side effects is low, evident in efficacy, moderate, adapt to industrialized great production by a large amount of tests and the research of preparation process.
Summary of the invention
The purpose of this invention is to provide a kind of treatment coronary heart disease, anginal medicine with the preparation of new type natural substrate adjuvant.
Another object of the present invention provides a kind of preparation method for the treatment of coronary heart disease, angina drug preparation.
Medicament selection acrid in the mouth of the present invention, Rhizoma Chuanxiong warm in nature is a monarch drug, has the Eradicates of the invigorating blood circulation stasis of blood, Eradicates wind analgesic function.Modern pharmacology proves that Rhizoma Chuanxiong has the effect of coronary artery dilator, coronary blood flow increasing and myocardial flow, reduction myocardial oxygen consumption; Can increase the effect of brain and LBF amount, reduction peripheral blood pressure resistance.Modern times are mainly used in the treatment of coronary heart disease, angina pectoris and ischemic breast angiopathy.Borneolum Syntheticum acrid in the mouth, hardship, cold nature, GUIXIN, spleen, lung meridian have the refreshment of having one's ideas straightened out, the effect of clearing away heat to alleviate pain.Be used for the treatment of clinically close disease coma, conjunctival congestion and swelling pain, sore throat aphtha,, disease such as coronary heart disease, angina pectoris and toothache, two medicine reasonable recipe have good curative effect.
The selected substrate adjuvant of the present invention is resulting by a large amount of tests, it is little to have molecular weight, soluble in water, and molten diffusing speed is faster, pure natural degree height, toxic and side effects is lower, and can reduce the medicine irritation abnormal smells from the patient, has the oral cavity of improvement acid-base value during the buccal of oral cavity, improve the characteristics of oral cavity smell, the used substrate adjuvant of the present invention is the agent of food sedan-chair flavor, takes that mouthfeel is good, the acceptant characteristics of patient, is the direction of following substrate adjuvant development.
The consumption of drug component of the present invention and the selection of adjuvant thereof also grope to sum up to draw through the inventor in a large number, and each amounts of components all has curative effect preferably in following ranges:
The consumption of drug component of the present invention is also groped to sum up to draw through the inventor in a large number, and each amounts of components all has curative effect preferably in following ranges:
80.1～99.9 parts of Rhizoma Chuanxiongs, 0.1～20 part of Borneolum Syntheticum, appropriate amount of auxiliary materials are made, wherein adjuvant comprises filler and plasticity substrate, said filler is selected from the natural adjuvant of following one or more plant origins: erythritol, sorbitol, fructose, D-ribonic acid-gamma lactone, arabitol, trehalose, D-ribose, low melting-point agarose, Lac, xylitol, Raffinose, glucose, malic acid, citric acid, isomalt, lactose, maltose etc., and they contain the water of crystallization chemical compound; Said plasticity substrate is selected from the natural adjuvant of following one or more plant origins: starch and derivant thereof, cellulose and derivant thereof, arabic gum, dextran, chitin, sesbania gum, carrageenan, Ficus elastica, Furcellaran, tragakanta, carrageenin, tamarind gum, pectin, xanthan gum, alginic acid and salt thereof, dextrin, cyclodextrin, agar, lactose; Described starch and derivant thereof such as pregelatinized Starch, modified starch, hydroxypropyl starch, carboxymethyl starch, described cellulose and derivant thereof such as methylcellulose, microcrystalline Cellulose, sodium carboxymethyl cellulose, hydroxypropyl emthylcellulose, cross-linking sodium carboxymethyl cellulose, hydroxyethylmethyl-cellulose, hydroxyethyl-cellulose, hydroxypropyl cellulose; Be chosen as 88.5～95.1 parts of the Rhizoma Chuanxiongs, 4.9～11.5 parts of Borneolum Syntheticums, appropriate amount of auxiliary materials of preferred drug component consumption of the present invention and adjuvant thereof are made, filler adjuvant wherein is selected from the natural adjuvant of following one or more plant origins: sorbitol, xylitol, lactose, maltose, and they contain the water of crystallization chemical compound; Plasticity substrate wherein is selected from the natural adjuvant of following one or more plant origins: pregelatinized Starch, carboxymethyl starch, methylcellulose, sodium carboxymethyl cellulose, hydroxypropyl emthylcellulose, arabic gum, alginic acid, dextrin, cyclodextrin, agar, lactose; Be chosen as 89.7～94.7 parts of the Rhizoma Chuanxiongs, 5.3～10.3 parts of Borneolum Syntheticums, appropriate amount of auxiliary materials of further preferred drug component consumption of the present invention and adjuvant thereof are made, and filler adjuvant wherein is selected from the natural adjuvant of following one or more plant origins: xylitol, lactose; Plasticity substrate wherein is selected from the natural adjuvant of following one or more plant origins: starch, arabic gum; Be chosen as 91.9 parts of the Rhizoma Chuanxiongs, 8.1 parts of Borneolum Syntheticums, appropriate amount of auxiliary materials of best drug component consumption of the present invention and adjuvant thereof are made, and filler adjuvant wherein is selected from the natural adjuvant of following one or more plant origins: xylitol, lactose; Plasticity substrate wherein is selected from the natural adjuvant of following one or more plant origins: starch, arabic gum.
Can also contain chemosynthesis adjuvant and animal origin adjuvant in the above-mentioned dressing, wherein filler comprises phenylglycol, hexadecanol, octadecanol, sodium stearate, tristerin, tripalmitin, carbamide, polyoxyethylene monostearate, polyoxyethylene alkyl ether; Wherein plasticity substrate comprises polyvinylpyrrolidone, crospolyvinylpyrrolidone, carbomer, polyvinyl alcohol, acrylic resin, poloxamer, gelatin.
In screening to above adjuvant, we find: plant colloid such as carrageenan, the tragakanta, pectin, agar, arabic gum, Ficus elastica, tamarind gum, locust bean gum, Pseudobulbus Bletillae (Rhizoma Bletillae) glue, guar gum, Konjac glucomannan, it is big that plant colloids such as POLY-karaya have viscosity, mobile poor, characteristics such as do not solidify after the condensation, and arabic gum has high dense low sticking character, can be mixed with the aqueous solution of 50% concentration and still have flowability, this is one of not available characteristics of other hydrophilic colloid, arabic gum has at high temperature, under the low concentration, can ooze, but not condensation, at low temperature, under the high concentration, be difficult for oozing, but characteristics such as energy condensation.Polysaccharide such as polysaccharide such as starch and derivant thereof (as gelling starch, carboxymethyl starch etc.), cellulose derivative (as methylcellulose, sodium carboxymethyl cellulose, hydroxypropyl emthylcellulose etc.), alginic acid, dextrin, cyclodextrin, lactose, in screening, find alginic acid have viscosity big, be the fruit jelly sample, dextrin has the colloid sample, characteristics such as lactose coagulability difference; And starch and derivant thereof are materials commonly used in the medical science adjuvant, thus in polysaccharide preferred starch and derivant thereof.Polyhydric alcohol such as sorbitol (88～102 ℃), xylitol (88～94.5 ℃), lactose (70～80 ℃), mannitol (166～169 ℃), maltose alcohol (135～140 ℃), isomalt polyhydric alcohol such as (98～103 ℃) screen, and find that it has following characteristics as drop pill substrate: sorbitol, lactose, isomalt are mobile poor; Mannitol, maltose alcohol fusing point are too high; The xylitol coagulability is poor slightly.After Preliminary screening, preferred xylitol, lactose, sorbitol in the selection of polyhydric alcohol, the best is an xylitol.Xylitol has following characteristics as drop pill substrate: in the time of 91 ℃, molten condition has appearred in xylitol, but not fusion fully, cooling rapidly, it separates out crystallization very soon, xylitol mixes the back good fluidity with extractum at certain proportion, can drip and can condensation, but be condensed into Powdered thing, loosely organized, the toughness extreme difference, that pinches is promptly broken.Organic acid and salt, alkali such as citric acid (100 ℃), sorbic acid (133 ℃), succinic acid (181～189 ℃), sodium acetate organic acid such as (58 ℃) and salt, alkali, its as drop pill substrate have fusing point too high, with Chinese medical concrete can't mixing etc. shortcoming.
Because of above single adjuvant existing shortcoming in as the drop pill preparation process, particularly we by above-mentioned Preliminary screening after, determine two kinds of adjuvants are used and screen: mainly be that above various adjuvants are carried out combined sorting, final determine following several: the plant colloid cooperates with the plant colloid, the cooperating of polyhydric alcohol and polyhydric alcohol, polyhydric alcohol and plant colloidally cooperate, the cooperating of the cooperating of xylitol and arabic gum, lactose and arabic gum, based on the composite auxiliary material of xylitol.Find preferred the cooperation to be xylitol, lactose and the compound use of other adjuvant, this kind combination has following characteristics: make up with mannitol: can drip not condensation; Make up with sorbic acid: both do not dissolve each other; Make up with lactose: can drip the energy condensation, but frangible; Make up with pomelo-pectin, tragakanta, sodium alginate: viscosity is big, can't drip; Make up with arabic gum: can drip, coagulability is poor slightly; Make up with dextrin: can drip, coagulability is poor slightly; Make up with starch: can drip, coagulability is also better.Determine that at last best of breed is that xylitol cooperates with arabic gum with starch, xylitol with starch, lactose.
At xylitol and starch, lactose and starch, in the research of xylitol and arabic gum combination, xylitol and starch Application of composite being prepared some required in the process of drop pill factors investigated, mainly is to the xylitol type, condensed fluid, condensate temperature influences the drop pill mouldability, xylitol and starch proportion influence mouldability, temperature is to the influence of drop pill mouldability, the extractum amount influences the drop pill mouldability, mixing time influences the drop pill mouldability, the dropper bore is to the influence of drop pill particle diameter, the formulation optimization of drop pill, the Preliminary Determination of drop pill, dissolve scattered time limit is investigated.Find that the solid xylitol has three types of powder, granular and crystallinity, and the easiest fusion of powder xylitol, again can fine dissolving be dispersed in the mixed liquor that starch, extractum forms, good fluidity, drippage is easy, and granular and crystalline xyhose alcohol is difficult for fusion, solubility property is also slightly poor, the mix flow that they and starch, extractum form is relatively poor, viscosity is very big, almost cannot drip, and therefore drips first-selected powder xylitol in the system process at drop pill.
At ratio of adjuvant molding is found in the sex research, in the combination of xylitol and starch, lactose and starch, xylitol and arabic gum, low melting point substrate adjuvant is 1: 0～1: 1.5 with the ratio of the weight of plasticity substrate adjuvant, be preferably 1: 0.1～1: 0.9, the best is 1: 0.1～1: 0.5.Low melting point substrate adjuvant of being formed within this scope and plasticity substrate adjuvant, the drug matrices fused solution all can ooze, and can condensation.Specific to each combination, xylitol is preferably 1: 0.2 with the ratio of the weight of starch～1: 0.3, and lactose is preferably 1: 0.2 with the ratio of the weight of starch～1: 0.3, and the ratio of the weight of xylitol and arabic gum is preferably 1: 0.2～and 1: 0.4.Find that in the research of temperature temperature is big especially to the influence of drop pill mouldability to the influence of drop pill mouldability, when temperature is too low, owing to the too big effect that oozes that influences drop pill of viscosity of substrate, when temperature is too high, not condensation of drop pill.Find that mixing time can have influence on the mouldability of drop pill in mixing time in to the sex research of drop pill molding, mixing time is too short, and mobile poor, influence oozes, and mixing time is oversize, influences the condensation of drop pill.Dripping under the system temperature, mixing time in 1～120 minute all can, suitable mixing time was at 10～30 minutes.Consider that mixing time can not be too short in the suitability for industrialized production, adopt the method that low temperature stirs for a long time, high temperature drips system.Find that in the research of dropper bore to the influence of drop pill particle diameter the dropper bore influences the size of drop pill and the flowability of fusion substrate, the system effect is dripped in influence.Drop pill diminishes and diminishes along with bore, but after 1.4 millimeters, along with the bore change of size that diminishes is not obvious, but the matrix flow reduction, system is dripped in influence.
So in the preparation method of preparation, medicine mixes mixing time with the substrate adjuvant be 10～30 minutes; The mixed heating and melting temperature of medicine and substrate adjuvant is 45～115 ℃, dripping the system temperature is 45～95 ℃, and liquid coolant is liquid paraffin, methyl-silicone oil or vegetable oil (Oleum Glycines, Semen Ricini wet goods), and the temperature of liquid coolant is-20～25 ℃, dropper mouth internal diameter is 1.0～4.0 millimeters; Preferred heating and melting temperature is 60～85 ℃, and dripping a system temperature is 60～85 ℃, and condensing agent is liquid paraffin, methyl-silicone oil, and the condensing agent temperature is 0～18 ℃, and the dropper bore is 1.1～3.5 millimeters, and the difference of dropper mouth external diameter and internal diameter is less for well; Best heating and melting temperature is that to make temperature be that 64 ℃, dropper bore are that 1.2～2.5 millimeters, condensing agent are 0 ℃ methyl-silicone oil to 64 ℃, droplet.
The substrate adjuvant of the best of the present invention is xylitol and starch, and xylitol is 1: 0.2～1: 0.3 with the ratio of the weight of starch; Or be lactose and starch, lactose is 1: 0.2～1: 0.3 with the ratio of the weight of starch; Or be xylitol and arabic gum, the ratio of the weight of xylitol and arabic gum is 1: 0.2～1: 0.4.
Xylitol is a kind of natural plant sweetening agent, approve through World Health Organization (WHO), xylitol is a kind of safest sweeting agent, countries in the world are extensive use of in fields such as food and oral-cavity articles, xylitol enters the help that need not insulin in the cell, when sugar utilizes obstacle, can not cause blood sugar increasing yet, can improve diabetics symptom, have the ketoplastic effect of powerful inhibition, can promote the generation of liver glycogen, directly infiltrate the Developmental and Metabolic Disorder that tissue is participated in metabolism, can be corrected protein, fat and steroid; Xylose is the internal metabolism intermediate product, and body has higher toleration to it.Clinical practice proves: the highest oral dosis tolerata can reach 220g every day, and intravenous drip every day can reach 100g.The oral 25700mg/Kg of median lethal dose(LD 50) (LD50) mice, quiet notes 6400mg/Kg, the quiet notes of rat 6200mg/Kg.
Medicine mesostroma adjuvant of the present invention and amount of drug are than can being the scope that allows on the galenic pharmacy, medicine described here can be that crude drug also can be the effective ingredient extract, in order to adapt to industrialized great production, the ratio range of mesostroma adjuvant of the present invention and medicine refers to the weight proportion of adjuvant and extract drugs extractum, and the substrate adjuvant is 1: 0.1～1: 1 with the ratio of the weight of drug extract; Preferred substrate adjuvant is 1: 0.1～1: 0.6 with the ratio of the weight of extract drugs extractum; Best substrate adjuvant is 1: 0.2～1: 0.4 with the ratio of the extraction extractum weight of medicine.
Medicine of the present invention can adopt the preparation of Chinese medicine preparation conventional method.The preparation of effective ingredient of the present invention can be adopted following method: water extraction, decoction and alcohol sedimentation technique, extraction, infusion process, percolation, reflux extraction, continuous backflow extraction method, macroreticular resin absorbing method preparation.For example, these crude drug pulverize mix homogeneously can be made powder takes after mixing it with water; Also can be with these medicines decocting together, the condensed water decocting liquid is made oral liquid then; But, preferably adopt following technology to extract, but this can not limit protection scope of the present invention to raw material in order to make each crude drug of this medicine better bring into play drug effect.
The preparation method of medicine of the present invention is as follows:
(a) it is standby to get 80.1～99.9 parts of Rhizoma Chuanxiongs, 0.1～20 part of Borneolum Syntheticum, appropriate amount of auxiliary materials;
(b) Rhizoma Chuanxiong is received cream with the ethanol heating extraction, use chloroform extraction, get Rhizoma Chuanxiong extract; Borneolum Syntheticum and above-mentioned Rhizoma Chuanxiong extract are added in the appropriate amount of auxiliary materials, fully mix, mixture is at 45～115 ℃ of heating and meltings, stir, mixing time is 1～120 minute, insulation, at 45～95 ℃ of temperature following system, dropper bore is 1.0～4.0 millimeters, splash in-20～25 ℃ liquid paraffin, methyl-silicone oil or the vegetable oil, make drop pill, promptly.
Preferred process for preparing medicine of the present invention comprises the following steps:
(a) it is standby to get 88.5～95.1 parts of Rhizoma Chuanxiongs, 4.9～11.5 parts of Borneolum Syntheticums, appropriate amount of auxiliary materials;
(b) Rhizoma Chuanxiong power is extracted with 30～99% alcohol heating reflux, decompression recycling ethanol, pure extractum, pure extractum is added hydrochloric acid or sulphuric acid adjusting PH2～6, use chloroform extraction, the chloroform layer hcl as extraction agent merges acid solution, regulate PH8～11 with ammonia, with chloroform extraction, the reclaim under reduced pressure chloroform is to there not being effluent again, get Rhizoma Chuanxiong extract, standby; Borneolum Syntheticum and above-mentioned Rhizoma Chuanxiong extract are added in the appropriate amount of auxiliary materials, fully mix, mixture is at 45～115 ℃ of heating and meltings, stir, mixing time is 1～120 minute, insulation, at 45～95 ℃ of temperature following system, dropper bore is 1.0～4.0 millimeters, splash in-20～25 ℃ liquid paraffin, methyl-silicone oil or the vegetable oil, make drop pill, promptly.
Further preferred process for preparing medicine of the present invention comprises the following steps:
(a) it is standby to get 89.7～94.7 parts of Rhizoma Chuanxiongs, 5.3～10.3 parts of Borneolum Syntheticums, appropriate amount of auxiliary materials;
(b) Rhizoma Chuanxiong power is extracted heating and refluxing extraction, decompression recycling ethanol with 50～90% alcohol heating reflux, get pure extractum, pure extractum is added hydrochloric acid or sulphuric acid adjusting PH3～5, use chloroform extraction, the chloroform layer hcl as extraction agent, merge acid solution, regulate PH8.5～10 with ammonia, again with chloroform extraction, the reclaim under reduced pressure chloroform, to there not being effluent, get Rhizoma Chuanxiong extract, standby; Borneolum Syntheticum and above-mentioned Rhizoma Chuanxiong extract are added in the appropriate amount of auxiliary materials, at 60～85 ℃ of heating and meltings, stir, mixing time is 10～30 minutes, insulation, at 60～85 ℃ of temperature following system, dropper bore is 1.1～3.5 millimeters, splash in 0～18 ℃ the liquid paraffin, methyl-silicone oil, to the greatest extent and wipe liquid coolant, back packing to be dried the drop pill drop that forms, make drop pill, promptly.
Best process for preparing medicine of the present invention comprises the following steps:
(a) it is standby to get 91.9 parts of Rhizoma Chuanxiongs, 8.1 parts of Borneolum Syntheticums, appropriate amount of auxiliary materials;
(b) Rhizoma Chuanxiong power is extracted heating and refluxing extraction, decompression recycling ethanol with 70～85% alcohol heating reflux, get pure extractum, pure extractum is added hydrochloric acid regulate PH4, use chloroform extraction, the chloroform layer hcl as extraction agent, merge acid solution, regulate PH9 with ammonia, again with chloroform extraction, the reclaim under reduced pressure chloroform, to there not being effluent, get Rhizoma Chuanxiong extract, standby; Borneolum Syntheticum and above-mentioned Rhizoma Chuanxiong extract are added in the appropriate amount of auxiliary materials, at 64 ℃ of heating and meltings, stir, mixing time is 10～30 minutes, insulation, at 64 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splash in 0 ℃ the methyl-silicone oil, to the greatest extent and wipe liquid coolant, back packing to be dried the drop pill drop that forms, make drop pill, promptly.
The best preparation method of medicine of the present invention is:
(a) it is standby to get 91.9 parts of Rhizoma Chuanxiongs, 8.1 parts of Borneolum Syntheticums, appropriate amount of auxiliary materials;
(b) Rhizoma Chuanxiong power is extracted heating and refluxing extraction, decompression recycling ethanol with 70～85% alcohol heating reflux, get pure extractum, pure extractum is added hydrochloric acid regulate PH4, use chloroform extraction, the chloroform layer hcl as extraction agent, merge acid solution, regulate PH9 with ammonia, again with chloroform extraction, the reclaim under reduced pressure chloroform, to there not being effluent, get Rhizoma Chuanxiong extract, standby; The ratio that Borneolum Syntheticum and above-mentioned Rhizoma Chuanxiong extract are added weight is 1: 0.2～1: 0.3 xylitol and starch mixture; Or the ratio of weight is 1: 0.2～1: 0.3 lactose and starch mixture; Or the ratio of weight is in 1: 0.2～1: 0.4 xylitol and the arabic gum mixture, at 64 ℃ of heating and meltings, stir, mixing time is 10～30 minutes, insulation, at 64 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splash in 0 ℃ the methyl-silicone oil, to the greatest extent and wipe liquid coolant, back packing to be dried the drop pill drop that forms, make drop pill, promptly.
More than form when producing and to increase or to reduce according to corresponding ratio, as large-scale production can be unit with kilogram or with the ton, small-scale production can be unit with the gram also, and weight can increase or reduce, but the crude drug material weight proportion constant rate between each composition.
More than each single medicinal material, especially adjuvant drug, messenger drug or adjuvant drug and messenger drug in forming, can be replaced by suitable Chinese medicine individually or simultaneously with the identical property of medicine, effect, it is constant to replace back Chinese medicine preparation and drug effect thereof.
Medicine of the present invention can be determined usage and dosage according to patient's situation in use, but every day 1-3 time, and every day, each crude drug consumption was as the criterion with the state-promulgated pharmacopoeia dosage, was no more than the pharmacopeia ormal weight.
The drop pill that the present invention is prepared, conventional drop pill advantage is simple as preparing except having, steady quality, can make liquid medicine solidification, convenient drug administration, efficient, quick-acting, its biggest advantage is:
1, the selected adjuvant pure natural of the present invention degree height: the substrate adjuvant that employed substrate adjuvant derives from natural plants or originates based on natural plants among the present invention, selected substrate adjuvant is xylitol and starch or lactose and starch or xylitol and arabic gum, this substrate adjuvant has pure natural degree height, toxic and side effects is low, mouthfeel is good, dissolve scattered time limit is short, rapid-action, it is a kind of new medium adjuvant, can be used for substituting present chemosynthesis adjuvant, the drop pill made from this kind adjuvant, it is low to solve the pure natural degree that present drop pill substrate faced, and more and more can not satisfy people and require back to nature, take low toxicity, the problem of the pure natural medical that has no side effect.
2, some problems in the outlet of solution Chinese medicine: medicine of the present invention also can solve Chinese medicine preparation, some problems of in exit procedure, being run into of dropping pill formulation particularly, solve because different countries, especially the European countries of industry prosperity are to the difference identification of the selected adjuvant of Chinese medicine dropping pill formulation, overcome as the selected adjuvant Polyethylene Glycol of the dropping pill formulation of the health food outlet defective in some national food additive catalogue not, improve the Chinese medicine dripping pills preparation and move towards the international market, strengthen the competitiveness of international market.
3, solve the relatively poor problem of dropping pill formulation taste and further improve drug effect speed (dissolve scattered time limit): the medicinal dropping ball made from this kind substrate adjuvant of the present invention, can improve Chinese medicine preparation, the particularly present not good shortcoming of dropping pill formulation taste, improve mouthfeel, more easy for patients to accept, and the drop pill that adopts the selected adjuvant of medicine of the present invention to make has shorter dissolve scattered time limit, making drug effect faster, is the medicine that coronary heart disease, angina pectoris, obstruction of qi in the chest and cardialgia, myocardial ischemia are treated in a kind of onset faster.
4, higher safety and solve some problems in the drop pill storage process: the selected substrate of the present invention is not only additive, nutrient commonly used in the food industry, and can do medicinal, but do not see that it uses as the drug matrices adjuvant, therefore, with regard to substrate, be perfectly safe, have no side effect, a large amount of evidences, the drop pill made from this adjuvant can reduce effective ingredient separating out in storage process, the sticking ball of drop pill, easy shortcomings such as moisture absorption deliquescing, but the big production of suitability for industrialized.
The present invention is under instruction of Chinese Medicine theory, preparation technology's test that process is a large amount of and pharmacology, the resulting preparation of pharmacodynamics test.Clinical symptoms such as the present invention is evident in efficacy, has removing heat from blood and promoting blood circulation, and the effect of the chest stuffiness relieving pain relieving is used for the treatment of obstruction of qi in the chest and cardialgia clinically, as diseases such as treatment coronary heart disease, angina pectoris, myocardial ischemia, is applicable to light, moderate obstruction of qi in the chest and cardialgia especially, and dysphoria with smothery sensation is thirsty.Medicament composing prescription of the present invention is reasonable, selected substrate adjuvant is xylitol and starch or lactose and starch or xylitol and arabic gum, this substrate adjuvant has pure natural degree height, toxic and side effects is low, mouthfeel is good, dissolve scattered time limit is short, rapid-action, it is a kind of new medium adjuvant, can be used for substituting present chemosynthesis adjuvant, with the drop pill that this kind adjuvant is made, it is low to solve the pure natural degree that present drop pill substrate faced, and can not satisfy more and more that people require back to nature, take low toxicity, the problem of the pure natural medical that has no side effect; Also can solve some problems that Chinese medicine preparation, particularly dropping pill formulation are run in exit procedure, strengthen the competitiveness of international market; In addition,, can improve the not good shortcoming of Chinese medicine preparation taste, improve mouthfeel with the drop pill that this kind substrate adjuvant is made, more easy for patients to accept, and have shorter dissolve scattered time limit, be the medicine that coronary heart disease, angina pectoris, obstruction of qi in the chest and cardialgia are treated in a kind of onset faster.
In order to understand the present invention better, different with dissolve scattered time limit, the ball method of double differences of SUXIAO JIUXIN WAN below, drop pill soft durometer, the sticking ball comparative test of drop pill illustrate advantage of the present invention.
Test example 1: dissolve scattered time limit, weight differential contrast experiment's example
In vitro tests
The present invention be that the SUXIAO JIUXIN WAN that adjuvant is made compares with the Polyethylene Glycol, by measuring index such as dissolve scattered time limit, investigate its good releasing effect; Whether by weight differential, it is ripe to investigate its preparation technology, whether is fit to suitability for industrialized production.
1. test medication: the new substrate SUXIAO JIUXIN WAN of the present invention (newly) is provided by the Jinshili Medicine Research ﹠. Development Co., Ltd., Tianjin; With the Polyethylene Glycol is the SUXIAO JIUXIN WAN (old) that adjuvant is made, and Chinese medicine six factories in Tianjin produce.
2. method and result:
Dissolve scattered time limit: by " method is measured under this item of Chinese pharmacopoeia; The ball method of double differences is different: by " method is measured under this item of Chinese pharmacopoeia.Result of the test sees Table 1.
Three batches of SUXIAO JIUXIN WAN made from the new medium adjuvant of table 1 (newly) with the polyethylene glycol 6000 be SUXIAO JIUXIN WAN (old) dissolve scattered time limit made of adjuvant, weight differential relatively
Test data shows, the dissolve scattered time limit of new substrate SUXIAO JIUXIN WAN is lacking of the SUXIAO JIUXIN WAN made of adjuvant with the Polyethylene Glycol; The ball method of double differences of the SUXIAO JIUXIN WAN that new and old substrate is made is different all to be controlled in the pharmacopeia prescribed limit.Presentation of results, the molten diffusing speed of the SUXIAO JIUXIN WAN made from novel adjuvant is faster, is more conducive to medicine and plays a role in the shortest time; The ball method of double differences is different all to be controlled in the pharmacopeia prescribed limit, and the alternative present chemosynthesis adjuvant of this natural substrates adjuvant is described, but suitability for industrialized production.
Test example 2: the present invention with the Polyethylene Glycol be the sticking ball comparative observation of SUXIAO JIUXIN WAN soft durometer, drop pill that adjuvant is made
The present invention be that the SUXIAO JIUXIN WAN that adjuvant is made compares with the Polyethylene Glycol, by measuring indexs such as above-mentioned, investigate its effect.
1. test medication: the new substrate SUXIAO JIUXIN WAN of the present invention (newly) is provided by the Jinshili Medicine Research ﹠. Development Co., Ltd., Tianjin; With the Polyethylene Glycol is the SUXIAO JIUXIN WAN (old) that adjuvant is made, and Chinese medicine six factories in Tianjin produce.
2. method and result:
Get three batches of new, old substrate SUXIAO JIUXIN WAN, be loaded in the porcelain vase respectively, and use the bottle stopper good seal.Putting it into the bottom has in the exsiccator of saturated Nacl (humidity 75%) solution, exsiccator is put into 40 ℃ of drying baker of constant temperature again, and timing sampling is observed situations such as drop pill soft durometer, the sticking ball of drop pill, the results are shown in Table 2.1, table 2.2.
Three batches in table 2.1 is that the SUXIAO JIUXIN WAN reserved sample observing that adjuvant is made compares with the Polyethylene Glycol
Table 2.2: three batches of SUXIAO JIUXIN WAN made from the new medium adjuvant (newly) with the Polyethylene Glycol be SUXIAO JIUXIN WAN (old) character observation made of adjuvant relatively
Above test data shows, the soft durometer of new substrate SUXIAO JIUXIN WAN changes and be that the SUXIAO JIUXIN WAN made of adjuvant is similar, strong slightly with the Polyethylene Glycol; The sticking ball variation of new substrate SUXIAO JIUXIN WAN, firmness change and be the similar of the SUXIAO JIUXIN WAN made of adjuvant with the Polyethylene Glycol.Presentation of results, the sticking ball of the drop pill that new and old substrate adjuvant is made changes, firmness change is similar, and the alternative present chemosynthesis adjuvant of this natural substrates adjuvant is described, but suitability for industrialized production.
The specific embodiment
Embodiment 1
(a) get Rhizoma Chuanxiong 30.4g, Borneolum Syntheticum 2.7g, xylitol 20g, starch 5g are standby;
(b) Rhizoma Chuanxiong, extraction volatile oil, volatile oil device is in addition collected, and the medicinal residues decocting boils secondary, is 2.5 hours for the first time, is 2 hours for the second time, collecting decoction is concentrated into that relative density is 1.25 in the time of 50 ℃, adds equivalent ethanol and makes precipitation, draws supernatant, filter, reclaim ethanol, concentrate, concentrated solution is standby;
(c) get volatile oil, Borneolum Syntheticum, add ethanol and dissolve in right amount, add the 4ml tween 80, make solubilising liquid;
(d) get xylitol and starch mix homogeneously, heating and melting adds clear paste and volatile oil solubilising liquid, stirs, and system is dripped in 75～85 ℃ of insulations, splashes in 0～5 ℃ of liquid paraffin, makes 1000 drop pill, promptly.
Embodiment 2
(a) get Rhizoma Chuanxiong 91.9g, Borneolum Syntheticum 8.1g, xylitol 183.6g, starch 55.4g are standby;
(b) Rhizoma Chuanxiong, extraction volatile oil, volatile oil device is in addition collected, and the medicinal residues decocting boils secondary, is 3.5 hours for the first time, is 2.5 hours for the second time, collecting decoction is concentrated into that relative density is 1.35 in the time of 50 ℃, adds equivalent ethanol and makes precipitation, draws supernatant, filter, reclaim ethanol, concentrate, concentrated solution is standby;
(c) get volatile oil, Borneolum Syntheticum, add ethanol and dissolve in right amount, add the 4ml tween 80, make solubilising liquid;
(d) xylitol and starch fully mix, and stir, and heating and melting adds clear paste and volatile oil solubilising liquid, stir, and system is dripped in 60～90 ℃ of insulations, splashes in 0～5 ℃ of liquid paraffin, makes 10000 drop pill, promptly.
Embodiment 3
(a) get Rhizoma Chuanxiong 9.2g, Borneolum Syntheticum 0.8g, xylitol 25.6g, starch 3.1g are standby;
(b) Rhizoma Chuanxiong, extraction volatile oil, volatile oil device is in addition collected, and the medicinal residues decocting boils secondary, is 5 hours for the first time, is 2 hours for the second time, collecting decoction is concentrated into that relative density is 1.35 in the time of 45 ℃, adds equivalent ethanol and makes precipitation, draws supernatant, filter, reclaim ethanol, concentrate, concentrated solution is standby;
(c) get volatile oil, Borneolum Syntheticum, add ethanol and dissolve in right amount, add the 4ml tween 80, make solubilising liquid;
(d) get xylitol and starch, fully mix, stir, heating and melting adds clear paste and volatile oil solubilising liquid, stirs, and system is dripped in 50～80 ℃ of insulations, splashes in the methyl-silicone oil, makes 1000 drop pill, promptly.
Embodiment 4
(a) get Rhizoma Chuanxiong 91.9g, Borneolum Syntheticum 8.1g, xylitol 183.6g, starch 55.4g are standby;
(b) Rhizoma Chuanxiong, extraction volatile oil, volatile oil device is in addition collected, and the medicinal residues decocting boils secondary, is 3.5 hours for the first time, is 2.5 hours for the second time, collecting decoction is concentrated into that relative density is 1.35 in the time of 50 ℃, adds equivalent ethanol and makes precipitation, draws supernatant, filter, reclaim ethanol, concentrate, concentrated solution is standby;
(c) get volatile oil, Borneolum Syntheticum, add ethanol and dissolve in right amount, add the 4ml tween 80, make solubilising liquid;
(d) xylitol and starch fully mix, and stir, and heating and melting adds clear paste and volatile oil solubilising liquid, stir, and system is dripped in 60～90 ℃ of insulations, splashes in 0～5 ℃ of liquid paraffin, makes 10000 drop pill, promptly.
Embodiment 5
(a) get Rhizoma Chuanxiong 9.9gg, Borneolum Syntheticum 0.1g, xylitol 22.5g, starch 7.5g are standby;
(b) Rhizoma Chuanxiong, extraction volatile oil, volatile oil device is in addition collected, and the medicinal residues decocting boils secondary, is 3 hours for the first time, is 2.5 hours for the second time, collecting decoction is concentrated into that relative density is 1.35 in the time of 50 ℃, adds equivalent ethanol and makes precipitation, draws supernatant, filter, reclaim ethanol, concentrate, concentrated solution is standby;
(c) get volatile oil, Borneolum Syntheticum, add ethanol and dissolve in right amount, add the 4ml tween 80, make solubilising liquid;
(d) xylitol and starch fully mix, and stir, and heating and melting adds clear paste and volatile oil solubilising liquid, stir, and system is dripped in 60～80 ℃ of insulations, splashes in 0～5 ℃ of liquid paraffin, makes 1000 drop pill, promptly.
Embodiment 6
(a) get Rhizoma Chuanxiong 9g, Borneolum Syntheticum 0.53g, xylitol 17g, starch 9g are standby;
(b) Rhizoma Chuanxiong, extraction volatile oil, volatile oil device is in addition collected, and the medicinal residues decocting boils secondary, is 4.5 hours for the first time, is 2.5 hours for the second time, collecting decoction is concentrated into that relative density is 1.40 in the time of 55 ℃, adds equivalent ethanol and makes precipitation, draws supernatant, filter, reclaim ethanol, concentrate, concentrated solution is standby;
(c) get volatile oil, Borneolum Syntheticum, add ethanol and dissolve in right amount, add the 4ml tween 80, make solubilising liquid;
(d) xylitol and starch fully mix, and stir, and heating and melting adds clear paste and volatile oil solubilising liquid, stir, and system is dripped in 60～85 ℃ of insulations, splashes in 0～8 ℃ of liquid paraffin, makes 1000 drop pill, promptly.
Embodiment 7
(a) get Rhizoma Chuanxiong 91.9g, Borneolum Syntheticum 8.1g, lactose 160g, starch 45g are standby;
(b) Rhizoma Chuanxiong, extraction volatile oil, volatile oil device is in addition collected, and the medicinal residues decocting boils secondary, is 2.5 hours for the first time, is 2 hours for the second time, collecting decoction is concentrated into that relative density is 1.25 in the time of 50 ℃, adds equivalent ethanol and makes precipitation, draws supernatant, filter, reclaim ethanol, concentrate, concentrated solution is standby;
(c) get volatile oil, Borneolum Syntheticum, add ethanol and dissolve in right amount, add the 4ml tween 80, make solubilising liquid;
(d) get lactose, starch mixing, stir, heating and melting adds clear paste and volatile oil solubilising liquid, stirs, and system is dripped in 75～85 ℃ of insulations, splashes in 0～5 ℃ of liquid paraffin, makes 10000 drop pill, promptly.
Embodiment 8
(a) get Rhizoma Chuanxiong 89.7g, Borneolum Syntheticum 10.3g, xylitol 180g, tragakanta 20g are standby;
(b) Rhizoma Chuanxiong, extraction volatile oil, volatile oil device is in addition collected, and the medicinal residues decocting boils secondary, is 3.5 hours for the first time, is 2 hours for the second time, collecting decoction is concentrated into that relative density is 1.37 in the time of 55 ℃, adds equivalent ethanol and makes precipitation, draws supernatant, filter, reclaim ethanol, concentrate, concentrated solution is standby;
(c) get volatile oil, Borneolum Syntheticum, add ethanol and dissolve in right amount, add the 4ml tween 80, make solubilising liquid;
(d) get xylitol, tragakanta mixing, stir, heating and melting adds clear paste and volatile oil solubilising liquid, stirs, and system is dripped in 50～75 ℃ of insulations, splashes in the methyl-silicone oil, makes 10000 drop pill, promptly.
Embodiment 9
(a) get it filled Rhizoma Chuanxiong 88.5g, Borneolum Syntheticum 4.9g, xylitol 210g, lactose 45g, chitin 35g is standby;
(b) Rhizoma Chuanxiong, extraction volatile oil, volatile oil device is in addition collected, and the medicinal residues decocting boils secondary, is 3.5 hours for the first time, is 2 hours for the second time, collecting decoction is concentrated into that relative density is 1.35 in the time of 50 ℃, adds equivalent ethanol and makes precipitation, draws supernatant, filter, reclaim ethanol, concentrate, concentrated solution is standby;
(c) get volatile oil, Borneolum Syntheticum, add ethanol and dissolve in right amount, add the 4ml tween 80, make solubilising liquid;
(d) get xylitol, lactose, chitin mixing, stir, heating and melting adds clear paste and volatile oil solubilising liquid, stirs, and system is dripped in 55～85 ℃ of insulations, splashes in the methyl-silicone oil, makes 10000 drop pill, promptly.
Embodiment 10
(a) by proportioning take by weighing each crude drug Rhizoma Chuanxiong 94.7g, Borneolum Syntheticum 5.3g, xylitol 224g, arabic gum 26g are standby;
(b) Rhizoma Chuanxiong, extraction volatile oil, volatile oil device is in addition collected, and the medicinal residues decocting boils secondary, is 3.5 hours for the first time, is 2 hours for the second time, collecting decoction is concentrated into that relative density is 1.35 in the time of 50 ℃, adds equivalent ethanol and makes precipitation, draws supernatant, filter, reclaim ethanol, concentrate, concentrated solution is standby;
(c) get volatile oil, Borneolum Syntheticum, add ethanol and dissolve in right amount, add the 4ml tween 80, make solubilising liquid;
(d) get xylitol, arabic gum mixing, stir, heating and melting adds clear paste and volatile oil solubilising liquid, stirs, and system is dripped in 70～85 ℃ of insulations, splashes in the liquid paraffin, makes 10000 drop pill, promptly.
Embodiment 11:
After the supercritical extraction Rhizoma Chuanxiong volatile oil, remainder extracts with low-concentration ethanol, concentrate extractum.
Extractum 12g, Borneolum Syntheticum 0.5g, lactose 35g, alginic acid 15g.
With lactose and the abundant mixing of alginic acid, put into drop pill and drip the system device, add extractum, volatile oil and Borneolum Syntheticum, fully stir evenly, heating in water bath, to fusion, bath temperature is 85 ℃.Under 65 ℃ of insulations fused mass being splashed into temperature with 35 droplets/minute speed is that back to be formed is with inhaling the liquid paraffin that the paper suction goes to stick to the drop pill surface in 0 ℃ the liquid paraffin liquid coolant, and cold drying promptly.The result shows, prepared drop pill rounding, even, consistent, the no adhesion phenomenon of color and luster of size.By measuring under Chinese Pharmacopoeia version in 2000 the method disintegration item, the result does not add baffle plate and passed through screen cloth in average 1 minute 53 seconds, meets the pharmacopeia regulation this disintegration.
Embodiment 12:
After the supercritical extraction Rhizoma Chuanxiong volatile oil, the remainder water extract-alcohol precipitation, concentrate extractum.
Extractum 13.5g, Borneolum Syntheticum 2.5g, xylitol 14.6g, starch 4.4g.
With xylitol and the abundant mixing of starch, put into drop pill and drip the system device, add extractum, volatile oil and Borneolum Syntheticum, fully stir evenly, heating in water bath, to fusion, bath temperature is 95 ℃.Under 65 ℃ of insulations fused mass being splashed into temperature with 25 droplets/minute speed is that back to be formed is with inhaling the methyl-silicone oil that the paper suction goes to stick to the drop pill surface in 5 ℃ the methyl-silicone oil liquid coolant, and cold drying promptly.The result shows, prepared drop pill rounding, even, consistent, the no adhesion phenomenon of color and luster of size.By measuring under Chinese Pharmacopoeia version in 2000 the method disintegration item, the result does not add baffle plate and passed through screen cloth in average 1 minute 55 seconds, meets the pharmacopeia regulation this disintegration.
Embodiment 13:
After the supercritical extraction Rhizoma Chuanxiong volatile oil, the remainder water extract-alcohol precipitation, concentrate extractum.
Extractum 8.5g, Borneolum Syntheticum 1.5g, xylitol 24.6g, starch 5.4g.
With xylitol and the abundant mixing of starch, put into drop pill and drip the system device, add extractum, volatile oil and Borneolum Syntheticum, fully stir evenly, mixture stirs at 64 ℃ of heating and meltings, mixing time is 10～30 minutes, insulation is 1.2～2.5 millimeters at 64 ℃ of temperature following system, dropper bore, splashes in 0 ℃ the methyl-silicone oil, liquid coolant is use up and wiped to the drop pill drop that forms, back packing to be dried is made 1000 drop pill, promptly.
Embodiment 14:
After the vapor extraction Rhizoma Chuanxiong volatile oil, remainder adopts Amberlyst process to be prepared into Rhizoma Chuanxiong extract, concentrate extractum.
Extractum 5.5g, Borneolum Syntheticum 2.0g, xylitol 20g, starch 5g.
With xylitol and the abundant mixing of starch, put into drop pill and drip the system device, add extractum, volatile oil and Borneolum Syntheticum, fully stir evenly, heating in water bath, to fusion, bath temperature is 85 ℃.Under 65 ℃ of insulations fused mass being splashed into temperature with 30 droplets/minute speed is 8 ℃ vegetable oil but in the liquid, and back to be formed is with inhaling the vegetable oil that the paper suction goes to stick to the drop pill surface, and cold drying promptly.The result shows, prepared drop pill rounding, even, consistent, the no adhesion phenomenon of color and luster of size.By measuring under Chinese Pharmacopoeia version in 2000 the method disintegration item, the result does not add baffle plate and passed through screen cloth in average 1 minute 59 seconds, meets the pharmacopeia regulation this disintegration.
Embodiment 15:
After the vapor extraction Rhizoma Chuanxiong volatile oil, remainder adopts Amberlyst process to be prepared into Rhizoma Chuanxiong extract, concentrate extractum.
Extractum 2.5g, Borneolum Syntheticum 0.5g, xylitol 21g, starch 3g.
With xylitol and the abundant mixing of starch, put into drop pill and drip the system device, add extractum, volatile oil and Borneolum Syntheticum, fully stir evenly, heating in water bath, to fusion, bath temperature is 85 ℃.Under 65 ℃ of insulations fused mass being splashed into temperature with 30 droplets/minute speed is 8 ℃ vegetable oil but in the liquid, and back to be formed is with inhaling the vegetable oil that the paper suction goes to stick to the drop pill surface, and cold drying promptly.The result shows, prepared drop pill rounding, even, consistent, the no adhesion phenomenon of color and luster of size.By measuring under Chinese Pharmacopoeia version in 2000 the method disintegration item, the result does not add baffle plate and passed through screen cloth in average 1 minute 58 seconds, meets the pharmacopeia regulation this disintegration.
Embodiment 16:
After the vapor extraction Rhizoma Chuanxiong volatile oil, remainder adopts Amberlyst process to be prepared into Rhizoma Chuanxiong extract, concentrate extractum.
Extractum 160.5g, Borneolum Syntheticum 40.0g, xylitol 150.5g, starch 50g.
With xylitol and the abundant mixing of starch, spray-dried system is made 50 bags of granules.
Embodiment 17
(a) get Rhizoma Chuanxiong 99.9g, Borneolum Syntheticum 0.1g, xylitol 25g, starch 5g are standby;
(b) Rhizoma Chuanxiong is received cream with 65% ethanol heating extraction, use chloroform extraction, get Rhizoma Chuanxiong extract; Borneolum Syntheticum and above-mentioned Rhizoma Chuanxiong extract are added in the appropriate amount of auxiliary materials, fully mix, mixture is at 45～115 ℃ of heating and meltings, stir, mixing time is 10～20 minutes, insulation, at 55～75 ℃ of temperature following system, dropper bore is 1.20～4.0 millimeters, splash in-20～25 ℃ the methyl-silicone oil, make 1000 drop pill, promptly.
Embodiment 18
(a) get Rhizoma Chuanxiong 80.1g, Borneolum Syntheticum 5.6g, lactose 20.3g, starch 4.6g are standby;
(b) Rhizoma Chuanxiong is received cream with 75% ethanol heating extraction, use chloroform extraction, get Rhizoma Chuanxiong extract; Borneolum Syntheticum and above-mentioned Rhizoma Chuanxiong extract are added in the appropriate amount of auxiliary materials, fully mix, mixture is at 55～85 ℃ of heating and meltings, stir, mixing time is 5～12 minutes, insulation, at 45～75 ℃ of temperature following system, dropper bore is 1.0～4.0 millimeters, splash in-20～25 ℃ the vegetable oil, make 1000 drop pill, promptly.
Embodiment 19
(a) get Rhizoma Chuanxiong 90g, Borneolum Syntheticum 1g, sorbitol 19.2g, xanthan gum 5.8g are standby;
(b) Rhizoma Chuanxiong is received cream with 65～80% ethanol heating extraction, use chloroform extraction, get Rhizoma Chuanxiong extract; Borneolum Syntheticum and above-mentioned Rhizoma Chuanxiong extract are added in the appropriate amount of auxiliary materials, fully mix, mixture is at 45～115 ℃ of heating and meltings, stir, mixing time is 1～120 minute, insulation, at 45～95 ℃ of temperature following system, dropper bore is 1.50～4.0 millimeters, splash in 0～10 ℃ the liquid paraffin, make 1000 drop pill, promptly.
Embodiment 20
(a) get Rhizoma Chuanxiong 88.5g, Borneolum Syntheticum 4.9g, xylitol 25.5g, starch 6.5g are standby;
(b) Rhizoma Chuanxiong power is extracted with 30～50% alcohol heating reflux, decompression recycling ethanol, pure extractum, pure extractum is added sulphuric acid regulate PH3.5～4.5, use chloroform extraction, the chloroform layer hcl as extraction agent merges acid solution, regulate PH8.5～9.5 with ammonia, with chloroform extraction, the reclaim under reduced pressure chloroform is to there not being effluent again, get Rhizoma Chuanxiong extract, standby; Borneolum Syntheticum and above-mentioned Rhizoma Chuanxiong extract are added in xylitol and the starch mixture, fully mix, mixture is at 45～115 ℃ of heating and meltings, stir, mixing time is 1～10 minute, insulation, at 55～75 ℃ of temperature following system, dropper bore is 1.20～3.0 millimeters, splash in 0～10 ℃ the methyl-silicone oil, make 1000 drop pill, promptly.
Embodiment 21
(a) get Rhizoma Chuanxiong 95.1g, Borneolum Syntheticum 4.9g, xylitol 22.4g, starch 5.6g are standby;
(b) Rhizoma Chuanxiong power is extracted with 50～80% alcohol heating reflux, decompression recycling ethanol, pure extractum, pure extractum is added hydrochloric acid regulate PH4, use chloroform extraction, the chloroform layer hcl as extraction agent merges acid solution, regulate PH9 with ammonia, with chloroform extraction, the reclaim under reduced pressure chloroform is to there not being effluent again, get Rhizoma Chuanxiong extract, standby; Borneolum Syntheticum and above-mentioned Rhizoma Chuanxiong extract are added in xylitol and the starch mixture, fully mix, mixture is at 80～105 ℃ of heating and meltings, stir, mixing time is 5～15 minutes, insulation, at 55～75 ℃ of temperature following system, dropper bore is 1.20～2.5 millimeters, splash in 5～15 ℃ the liquid paraffin, make 1000 drop pill, promptly.
Embodiment 22
(a) get Rhizoma Chuanxiong 90g, Borneolum Syntheticum 10g, xylitol 20g, arabic gum 5.5g are standby;
(b) Rhizoma Chuanxiong power is extracted with 75～95% alcohol heating reflux, decompression recycling ethanol, pure extractum, pure extractum is added hydrochloric acid regulate PH6, use chloroform extraction, the chloroform layer hcl as extraction agent merges acid solution, regulate PH9 with ammonia, with chloroform extraction, the reclaim under reduced pressure chloroform is to there not being effluent again, get Rhizoma Chuanxiong extract, standby; Borneolum Syntheticum and above-mentioned Rhizoma Chuanxiong extract are added in xylitol and the arabic gum mixture, fully mix, mixture is at 60～65 ℃ of heating and meltings, stir, mixing time is 5 minutes, insulation, at 60～65 ℃ of temperature following system, dropper bore is 1.20～4.0 millimeters, splash in 5 ℃ the methyl-silicone oil or vegetable oil, make 1000 drop pill, promptly.
Embodiment 23
(a) get Rhizoma Chuanxiong 9g, Borneolum Syntheticum 0.2g, xylitol 27.5g, hydroxypropyl starch 7.5g are standby;
(b) Rhizoma Chuanxiong power is extracted heating and refluxing extraction, decompression recycling ethanol with 75% alcohol heating reflux, get pure extractum, pure extractum is added hydrochloric acid regulate PH3, use chloroform extraction, the chloroform layer hcl as extraction agent, merge acid solution, regulate PH8.5 with ammonia, again with chloroform extraction, the reclaim under reduced pressure chloroform, to there not being effluent, get Rhizoma Chuanxiong extract, standby; Borneolum Syntheticum and above-mentioned Rhizoma Chuanxiong extract are added in xylitol and the hydroxypropyl starch mixture, at 60～85 ℃ of heating and meltings, stir, mixing time is 10～30 minutes, insulation, at 60～85 ℃ of temperature following system, dropper bore is 1.1～3.5 millimeters, splash in 0～18 ℃ the liquid paraffin, methyl-silicone oil, to the greatest extent and wipe liquid coolant, back packing to be dried the drop pill drop that forms, make 1000 drop pill, promptly.
Embodiment 24
(a) get Rhizoma Chuanxiong 6g, Borneolum Syntheticum 2g, lactose 31.25g, starch 3.65g are standby;
(b) Rhizoma Chuanxiong power is extracted heating and refluxing extraction, decompression recycling ethanol with 50～90% alcohol heating reflux, get pure extractum, pure extractum is added sulphuric acid regulate PH4, use chloroform extraction, the chloroform layer hcl as extraction agent, merge acid solution, regulate PH9 with ammonia, again with chloroform extraction, the reclaim under reduced pressure chloroform, to there not being effluent, get Rhizoma Chuanxiong extract, standby; Borneolum Syntheticum and above-mentioned Rhizoma Chuanxiong extract are added in lactose and the starch mixture, at 60～85 ℃ of heating and meltings, stir, mixing time is 10～30 minutes, insulation, at 60～85 ℃ of temperature following system, dropper bore is 1.1～3.5 millimeters, splash in 0～18 ℃ the liquid paraffin, methyl-silicone oil, to the greatest extent and wipe liquid coolant, back packing to be dried the drop pill drop that forms, make 1000 drop pill, promptly.
Embodiment 25
(a) get Rhizoma Chuanxiong 91.9g, Borneolum Syntheticum 8.1g, xylitol 20.3g, starch 6.1g are standby;
(b) Rhizoma Chuanxiong power is extracted heating and refluxing extraction, decompression recycling ethanol with 70～85% alcohol heating reflux, get pure extractum, pure extractum is added hydrochloric acid regulate PH4, use chloroform extraction, the chloroform layer hcl as extraction agent, merge acid solution, regulate PH9 with ammonia, again with chloroform extraction, the reclaim under reduced pressure chloroform, to there not being effluent, get Rhizoma Chuanxiong extract, standby; Borneolum Syntheticum and above-mentioned Rhizoma Chuanxiong extract and xylitol and starch mixture is evenly mixed, at 64 ℃ of heating and meltings, stir, mixing time is 10～30 minutes, insulation, at 64 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splash in 0 ℃ the methyl-silicone oil, to the greatest extent and wipe liquid coolant, back packing to be dried the drop pill drop that forms, make 1000 drop pill, promptly.
Embodiment 26
(a) get Rhizoma Chuanxiong 91.9g, Borneolum Syntheticum 8.1g, xylitol 21.5g, xanthan gum 4.5g are standby;
(b) Rhizoma Chuanxiong power is extracted heating and refluxing extraction, decompression recycling ethanol with 70～85% alcohol heating reflux, get pure extractum, pure extractum is added hydrochloric acid regulate PH4, use chloroform extraction, the chloroform layer hcl as extraction agent, merge acid solution, regulate PH9 with ammonia, again with chloroform extraction, the reclaim under reduced pressure chloroform, to there not being effluent, get Rhizoma Chuanxiong extract, standby; Borneolum Syntheticum and above-mentioned Rhizoma Chuanxiong are extracted in adding xylitol and the xanthan gum mixtures, mixing at 64 ℃ of heating and meltings, stirs, mixing time is 10～30 minutes, insulation is 1.2～2.5 millimeters at 64 ℃ of temperature following system, dropper bore, splashes in 0 ℃ the methyl-silicone oil, liquid coolant is use up and wiped to the drop pill drop that forms, back packing to be dried is made 1000 drop pill, promptly.
Claims (17)
1, a kind ofly is used for the treatment for the treatment of coronary heart disease and angina pectoris by what Rhizoma Chuanxiong, Borneolum Syntheticum, substrate adjuvant were made, it is characterized in that it is is that raw material adds that appropriate amount of auxiliary materials makes by 0.1～20 part of 80.1～99.9 parts of Rhizoma Chuanxiong, Borneolum Syntheticum, wherein adjuvant is made up of filler and plasticity substrate, and said filler is selected from the natural adjuvant of following one or more plant origins: erythritol, sorbitol, arabitol, trehalose, xylitol, Raffinose, glucose, isomalt, lactose, maltose; Said plasticity substrate is selected from the natural adjuvant of following one or more plant origins: starch and derivant thereof, cellulose and derivant thereof, arabic gum, chitin, tragakanta, xanthan gum, alginic acid, dextrin, cyclodextrin, agar, lactose; Described starch and derivant thereof are hydroxypropyl starch.
2, as claimed in claim 1ly be used for the treatment for the treatment of coronary heart disease and angina pectoris by what Rhizoma Chuanxiong, Borneolum Syntheticum, substrate adjuvant were made, it is characterized in that it is is that raw material adds that appropriate amount of auxiliary materials makes by 4.9～11.5 parts of 88.5～95.1 parts of Rhizoma Chuanxiongs, Borneolum Syntheticum, filler adjuvant wherein is selected from the natural adjuvant of following one or more plant origins: sorbitol, xylitol, lactose, maltose; Plasticity substrate wherein is selected from natural adjuvant arabic gum, alginic acid, dextrin, cyclodextrin, agar, the lactose of following one or more plant origins.
3, as claimed in claim 1ly be used for the treatment of the treating coronary heart disease and angina pectoris compositions by what Rhizoma Chuanxiong, Borneolum Syntheticum, substrate adjuvant were made, it is characterized in that it is is that raw material adds that appropriate amount of auxiliary materials makes by 5.3～10.3 parts of 89.7～94.7 parts of Rhizoma Chuanxiongs, Borneolum Syntheticum, filler adjuvant wherein is selected from the natural adjuvant of following one or more plant origins: xylitol, lactose; Plasticity substrate wherein is selected from the natural adjuvant of following one or more plant origins: starch, arabic gum.
4, as claimed in claim 3ly be used for the treatment of the treating coronary heart disease and angina pectoris compositions by what Rhizoma Chuanxiong, Borneolum Syntheticum, substrate adjuvant were made, it is characterized in that it is is that raw material adds that appropriate amount of auxiliary materials makes by 8.1 parts of 91.9 parts of Rhizoma Chuanxiongs, Borneolum Syntheticum, filler adjuvant wherein is selected from the natural adjuvant of following one or more plant origins: xylitol, lactose; Plasticity substrate wherein is selected from the natural adjuvant of following one or more plant origins: starch, arabic gum.
5, treatment treating coronary heart disease and angina pectoris as claimed in claim 4 is characterized in that described adjuvant is xylitol and starch, and xylitol is 1: 0.2～1: 0.3 with the ratio of the weight of starch.
6, treatment treating coronary heart disease and angina pectoris as claimed in claim 4 is characterized in that described adjuvant is lactose and starch, and lactose is 1: 0.2～1: 0.3 with the ratio of the weight of starch.
7, treatment treating coronary heart disease and angina pectoris as claimed in claim 4 is characterized in that described adjuvant is xylitol and arabic gum, and the ratio of the weight of xylitol and arabic gum is 1: 0.2～1: 0.4.
8, as being used for the treatment for the treatment of coronary heart disease and angina pectoris by what Rhizoma Chuanxiong, Borneolum Syntheticum, substrate adjuvant were made as described in the claim 1,2,3 or 4, it is characterized in that the substrate adjuvant and the ratio of the weight of crude drug extract are 1: 0.1～1: 1.
9, as claimed in claim 8ly be used for the treatment for the treatment of coronary heart disease and angina pectoris, it is characterized in that the substrate adjuvant and the ratio of the weight of crude drug extract are 1: 0.1～1: 0.6 by what Rhizoma Chuanxiong, Borneolum Syntheticum, substrate adjuvant were made.
10, as claimed in claim 8ly be used for the treatment for the treatment of coronary heart disease and angina pectoris, it is characterized in that the substrate adjuvant and the ratio of the weight of crude drug are 1: 0.2～1: 0.4 by what Rhizoma Chuanxiong, Borneolum Syntheticum, substrate adjuvant were made.
11, claim 1,2,3 or 4 described treatment treating coronary heart disease and angina pectoris, it is characterized in that to adopt water extraction, decoction and alcohol sedimentation technique, extraction, infusion process, percolation, reflux extraction, the continuous backflow extraction method, present visible Chinese herbal medicine effective ingredients extraction method such as macroreticular resin absorbing method is extracted, and effective ingredient and adjuvant are made tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, pill, powder, unguentum, sublimed preparation, suspensoid, powder, solution, injection, suppository, ointment, plaster, spray, drop pill.
12, treatment treating coronary heart disease and angina pectoris as claimed in claim 11, it is characterized in that to adopt decoction and alcohol sedimentation technique, extraction, continuous backflow extraction method to carry out the Chinese medicine extracts active ingredients, effective ingredient and adjuvant are made granule, electuary, powder, injection, drop pill.
13, treatment treating coronary heart disease and angina pectoris as claimed in claim 11 is characterized in that adopting decoction and alcohol sedimentation technique, extraction to carry out the Chinese medicine extracts active ingredients, and effective ingredient and adjuvant are made drop pill.
14, the preparation method of treatment angina pectoris medicine as claimed in claim 12 is characterized in that this method comprises the steps:
(a) it is standby to get 80.1～99.9 parts of Rhizoma Chuanxiongs, 0.1～20 part of Borneolum Syntheticum, appropriate amount of auxiliary materials;
(b) Rhizoma Chuanxiong is received cream with the ethanol heating extraction, use chloroform extraction, get Rhizoma Chuanxiong extract; Borneolum Syntheticum and above-mentioned Rhizoma Chuanxiong extract are added in the appropriate amount of auxiliary materials, fully mix, mixture is at 45～115 ℃ of heating and meltings, stir, mixing time is 1～120 minute, insulation, at 45～95 ℃ of temperature following system, dropper bore is 1.0～4.0 millimeters, splash in-20～25 ℃ liquid paraffin, methyl-silicone oil or the vegetable oil, make drop pill, promptly.
15, the preparation method of treatment angina pectoris medicine as claimed in claim 14 is characterized in that this method method comprises the steps:
(a) it is standby to get 88.5～95.1 parts of Rhizoma Chuanxiongs, 4.9～11.5 parts of Borneolum Syntheticums, appropriate amount of auxiliary materials;
(b) Rhizoma Chuanxiong power is extracted with 30～99% alcohol heating reflux, decompression recycling ethanol, pure extractum, pure extractum is added hydrochloric acid or sulphuric acid adjusting PH2～6, use chloroform extraction, the chloroform layer hcl as extraction agent merges acid solution, regulate PH8～11 with ammonia, with chloroform extraction, the reclaim under reduced pressure chloroform is to there not being effluent again, get Rhizoma Chuanxiong extract, standby; Borneolum Syntheticum and above-mentioned Rhizoma Chuanxiong extract are added in the appropriate amount of auxiliary materials, fully mix, mixture is at 45～115 ℃ of heating and meltings, stir, mixing time is 1～120 minute, insulation, at 45～95 ℃ of temperature following system, dropper bore is 1.0～4.0 millimeters, splash in-20～25 ℃ liquid paraffin, methyl-silicone oil or the vegetable oil, make drop pill, promptly.
16, the preparation method of treatment angina pectoris medicine as claimed in claim 14 is characterized in that this method comprises the steps:
(a) it is standby to get 89.7～94.7 parts of Rhizoma Chuanxiongs, 5.3～10.3 parts of Borneolum Syntheticums, appropriate amount of auxiliary materials;
(b) Rhizoma Chuanxiong power is extracted heating and refluxing extraction, decompression recycling ethanol with 50～90% alcohol heating reflux, get pure extractum, pure extractum is added hydrochloric acid or sulphuric acid adjusting PH3～5, use chloroform extraction, the chloroform layer hcl as extraction agent, merge acid solution, regulate PH8.5～10 with ammonia, again with chloroform extraction, the reclaim under reduced pressure chloroform, to there not being effluent, get Rhizoma Chuanxiong extract, standby; Borneolum Syntheticum and above-mentioned Rhizoma Chuanxiong extract are added in the appropriate amount of auxiliary materials, at 60～85 ℃ of heating and meltings, stir, mixing time is 10～30 minutes, insulation, at 60～85 ℃ of temperature following system, dropper bore is 1.1～3.5 millimeters, splash in 0～18 ℃ the liquid paraffin, methyl-silicone oil, to the greatest extent and wipe liquid coolant, back packing to be dried the drop pill drop that forms, make drop pill, promptly.
17, the preparation method of treatment angina pectoris medicine as claimed in claim 14 is characterized in that this method comprises the steps:
(a) it is standby to get 91.9 parts of Rhizoma Chuanxiongs, 8.1 parts of Borneolum Syntheticums, appropriate amount of auxiliary materials;
(b) Rhizoma Chuanxiong power is extracted heating and refluxing extraction, decompression recycling ethanol with 70～85% alcohol heating reflux, get pure extractum, pure extractum is added hydrochloric acid regulate PH4, use chloroform extraction, the chloroform layer hcl as extraction agent, merge acid solution, regulate PH9 with ammonia, again with chloroform extraction, the reclaim under reduced pressure chloroform, to there not being effluent, get Rhizoma Chuanxiong extract, standby; With Borneolum Syntheticum and above-mentioned Rhizoma Chuanxiong extract mixture at 64 ℃ of heating and meltings, stir, mixing time is 10～30 minutes, insulation is 1.2～2.5 millimeters at 64 ℃ of temperature following system, dropper bore, splashes in 0 ℃ the methyl-silicone oil, liquid coolant is use up and wiped to the drop pill drop that forms, back packing to be dried is made drop pill, promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2003101072901A CN100553619C (en) | 2003-12-11 | 2003-12-11 | A kind of treatment coronary heart disease, anginal medicine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2003101072901A CN100553619C (en) | 2003-12-11 | 2003-12-11 | A kind of treatment coronary heart disease, anginal medicine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1626131A CN1626131A (en) | 2005-06-15 |
| CN100553619C true CN100553619C (en) | 2009-10-28 |
Family
ID=34758099
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2003101072901A Expired - Fee Related CN100553619C (en) | 2003-12-11 | 2003-12-11 | A kind of treatment coronary heart disease, anginal medicine |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100553619C (en) |
-
2003
- 2003-12-11 CN CNB2003101072901A patent/CN100553619C/en not_active Expired - Fee Related
Non-Patent Citations (2)
| Title |
|---|
| 国家药品标准 中药成方制剂第18册. 国家药典委员会，295，国家药典委员会. 1998 |
| 国家药品标准 中药成方制剂第18册. 国家药典委员会，295，国家药典委员会. 1998 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1626131A (en) | 2005-06-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN100553615C (en) | A kind of medicine for the treatment of cardiovascular and cerebrovascular disease | |
| CN100421721C (en) | Medication for relieving cough and asthma | |
| CN100450504C (en) | Medication for treating pharyngitis | |
| CN100455314C (en) | Medication for treating cough | |
| CN100563635C (en) | A kind of ageratum drop pill | |
| CN1872232B (en) | Composition of medication for curing cerebrovascular disease, and preparation method | |
| CN1872327B (en) | Composition of medicine for treating diarrhea | |
| CN100421684C (en) | Medication for treating coronary heart disease and angina | |
| CN100553619C (en) | A kind of treatment coronary heart disease, anginal medicine | |
| CN100563673C (en) | Chinese medicine preparation of treatment angina pectoris and preparation method thereof | |
| CN100553617C (en) | A kind of medicine for the treatment of obstruction of qi in the chest and cardialgia | |
| CN100563634C (en) | A kind of Herba Sidae Rhombifoliae soup drop pill | |
| CN100502840C (en) | Medication for treating chronic rhinitis and nasal sinusitis | |
| CN1872250B (en) | Composition of medication for treating headache | |
| CN100553620C (en) | A kind of medicine for the treatment of the thoracic obstruction | |
| CN1872230B (en) | A medication for treating coronary heart disease and preparation method | |
| CN100421658C (en) | Medication for treating coronary heart disease and angina | |
| CN100421702C (en) | Medication for treating obstruction of qi in the chest | |
| CN100512824C (en) | Medication for treating headache | |
| CN100512833C (en) | Medication for treating cough | |
| CN1626133B (en) | Medication for treating coronary heart disease | |
| CN100430070C (en) | Medication for treating coronary heart disease and angina | |
| CN100512832C (en) | Medication for treating ache | |
| CN100553618C (en) | A kind of medicine for the treatment of toothache | |
| CN100536831C (en) | Medication for treating cardiovascular and cerebrovascular diseases |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C56 | Change in the name or address of the patentee |
Owner name: TASLY PHARMACEUTICAL GROUP CO., LTD. Free format text: FORMER NAME: TIANJIN TASLY PHARMACEUTICAL CO., LTD. |
|
| CP01 | Change in the name or title of a patent holder |
Address after: 300402 Tianjin science and Technology Park of Beichen Xinyi Road Liaohe Road No. 1 white Patentee after: Tasly Pharmaceutical Group Co., Ltd. Address before: 300402 Tianjin science and Technology Park of Beichen Xinyi Road Liaohe Road No. 1 white Patentee before: Tianjin Tianshili Pharmaceutical Co., Ltd. |
|
| CP01 | Change in the name or title of a patent holder |
Address after: 300402 Tianjin science and Technology Park of Beichen Xinyi Road Liaohe Road No. 1 white Patentee after: Tasly Pharmaceutical Group Limited by Share Ltd Address before: 300402 Tianjin science and Technology Park of Beichen Xinyi Road Liaohe Road No. 1 white Patentee before: Tasly Pharmaceutical Group Co., Ltd. |
|
| CP01 | Change in the name or title of a patent holder | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20091028 Termination date: 20191211 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |