CN100430070C - Medication for treating coronary heart disease and angina - Google Patents
Medication for treating coronary heart disease and angina Download PDFInfo
- Publication number
- CN100430070C CN100430070C CNB2003101072973A CN200310107297A CN100430070C CN 100430070 C CN100430070 C CN 100430070C CN B2003101072973 A CNB2003101072973 A CN B2003101072973A CN 200310107297 A CN200310107297 A CN 200310107297A CN 100430070 C CN100430070 C CN 100430070C
- Authority
- CN
- China
- Prior art keywords
- parts
- adjuvant
- medicine
- styrax
- standby
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000003814 drug Substances 0.000 title claims abstract description 120
- 206010002383 Angina Pectoris Diseases 0.000 title claims abstract description 26
- 229940079593 drug Drugs 0.000 title claims description 43
- 208000029078 coronary artery disease Diseases 0.000 title abstract description 11
- 239000006187 pill Substances 0.000 claims abstract description 91
- 238000002360 preparation method Methods 0.000 claims abstract description 39
- 239000000463 material Substances 0.000 claims abstract description 24
- 239000002671 adjuvant Substances 0.000 claims description 109
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 104
- 239000000203 mixture Substances 0.000 claims description 71
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 69
- 235000015511 Liquidambar orientalis Nutrition 0.000 claims description 68
- 241000736148 Styrax Species 0.000 claims description 68
- 239000004870 Styrax Substances 0.000 claims description 68
- 235000000126 Styrax benzoin Nutrition 0.000 claims description 68
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 68
- 235000010447 xylitol Nutrition 0.000 claims description 68
- 239000000811 xylitol Substances 0.000 claims description 68
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 68
- 229960002675 xylitol Drugs 0.000 claims description 68
- 229920002472 Starch Polymers 0.000 claims description 55
- 239000008107 starch Substances 0.000 claims description 55
- 235000019698 starch Nutrition 0.000 claims description 55
- 241000717739 Boswellia sacra Species 0.000 claims description 53
- 239000000758 substrate Substances 0.000 claims description 53
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims description 52
- 239000000341 volatile oil Substances 0.000 claims description 51
- 238000010438 heat treatment Methods 0.000 claims description 47
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 33
- 238000002156 mixing Methods 0.000 claims description 33
- 235000010489 acacia gum Nutrition 0.000 claims description 32
- 239000001785 acacia senegal l. willd gum Substances 0.000 claims description 32
- 239000008101 lactose Substances 0.000 claims description 32
- 238000002844 melting Methods 0.000 claims description 27
- 230000008018 melting Effects 0.000 claims description 27
- 239000007788 liquid Substances 0.000 claims description 24
- 238000001035 drying Methods 0.000 claims description 23
- 238000010992 reflux Methods 0.000 claims description 23
- 229920002545 silicone oil Polymers 0.000 claims description 23
- 238000003756 stirring Methods 0.000 claims description 23
- 241000196324 Embryophyta Species 0.000 claims description 22
- 239000004863 Frankincense Substances 0.000 claims description 22
- 238000009413 insulation Methods 0.000 claims description 22
- 238000000034 method Methods 0.000 claims description 22
- 239000002826 coolant Substances 0.000 claims description 21
- 238000012856 packing Methods 0.000 claims description 19
- 239000000945 filler Substances 0.000 claims description 18
- 241000726094 Aristolochia Species 0.000 claims description 16
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 11
- PYMYPHUHKUWMLA-LMVFSUKVSA-N aldehydo-D-ribose Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 claims description 10
- 229940057995 liquid paraffin Drugs 0.000 claims description 10
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 9
- 239000000600 sorbitol Substances 0.000 claims description 9
- 241001597008 Nomeidae Species 0.000 claims description 8
- 229920002101 Chitin Polymers 0.000 claims description 7
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 7
- 235000010443 alginic acid Nutrition 0.000 claims description 7
- 229920000615 alginic acid Polymers 0.000 claims description 7
- 239000000783 alginic acid Substances 0.000 claims description 7
- 229960001126 alginic acid Drugs 0.000 claims description 7
- 150000004781 alginic acids Chemical class 0.000 claims description 7
- 229940032147 starch Drugs 0.000 claims description 7
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 claims description 6
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 claims description 6
- 239000004386 Erythritol Substances 0.000 claims description 5
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 claims description 5
- 229930091371 Fructose Natural products 0.000 claims description 5
- 239000005715 Fructose Substances 0.000 claims description 5
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 claims description 5
- 244000275012 Sesbania cannabina Species 0.000 claims description 5
- 235000019414 erythritol Nutrition 0.000 claims description 5
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 claims description 5
- 229940009714 erythritol Drugs 0.000 claims description 5
- 235000015112 vegetable and seed oil Nutrition 0.000 claims description 4
- 239000008158 vegetable oil Substances 0.000 claims description 4
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims description 2
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims description 2
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims description 2
- 206010061876 Obstruction Diseases 0.000 claims 15
- 239000004014 plasticizer Substances 0.000 claims 10
- 230000000694 effects Effects 0.000 abstract description 25
- 231100000331 toxic Toxicity 0.000 abstract description 10
- 230000002588 toxic effect Effects 0.000 abstract description 10
- 235000013373 food additive Nutrition 0.000 abstract description 3
- 239000002778 food additive Substances 0.000 abstract description 3
- 206010013911 Dysgeusia Diseases 0.000 abstract 1
- 230000007547 defect Effects 0.000 abstract 1
- 239000000796 flavoring agent Substances 0.000 description 32
- 235000019634 flavors Nutrition 0.000 description 32
- 239000000843 powder Substances 0.000 description 19
- 235000019640 taste Nutrition 0.000 description 19
- 239000000706 filtrate Substances 0.000 description 15
- 238000004064 recycling Methods 0.000 description 15
- 238000012360 testing method Methods 0.000 description 14
- 238000009472 formulation Methods 0.000 description 12
- 238000004519 manufacturing process Methods 0.000 description 12
- -1 hydroxypropyl Chemical group 0.000 description 10
- 239000002202 Polyethylene glycol Substances 0.000 description 9
- 238000009833 condensation Methods 0.000 description 9
- 230000005494 condensation Effects 0.000 description 9
- 229920001223 polyethylene glycol Polymers 0.000 description 9
- 201000010099 disease Diseases 0.000 description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 8
- 238000011160 research Methods 0.000 description 8
- 239000003795 chemical substances by application Substances 0.000 description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- 239000000084 colloidal system Substances 0.000 description 6
- 210000000214 mouth Anatomy 0.000 description 6
- 230000008569 process Effects 0.000 description 6
- 150000005846 sugar alcohols Polymers 0.000 description 6
- 229920001353 Dextrin Polymers 0.000 description 5
- 239000004375 Dextrin Substances 0.000 description 5
- 230000008901 benefit Effects 0.000 description 5
- 230000008859 change Effects 0.000 description 5
- 235000019425 dextrin Nutrition 0.000 description 5
- 238000005516 engineering process Methods 0.000 description 5
- 229920000591 gum Polymers 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 4
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 4
- 208000002193 Pain Diseases 0.000 description 4
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 4
- 239000001768 carboxy methyl cellulose Substances 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 230000018109 developmental process Effects 0.000 description 4
- 230000000857 drug effect Effects 0.000 description 4
- 230000003203 everyday effect Effects 0.000 description 4
- 238000000605 extraction Methods 0.000 description 4
- 235000013305 food Nutrition 0.000 description 4
- 230000004927 fusion Effects 0.000 description 4
- 239000004615 ingredient Substances 0.000 description 4
- 239000006225 natural substrate Substances 0.000 description 4
- 229940093429 polyethylene glycol 6000 Drugs 0.000 description 4
- 238000012216 screening Methods 0.000 description 4
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 4
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 238000005303 weighing Methods 0.000 description 4
- SERLAGPUMNYUCK-DCUALPFSSA-N 1-O-alpha-D-glucopyranosyl-D-mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O SERLAGPUMNYUCK-DCUALPFSSA-N 0.000 description 3
- 229920001817 Agar Polymers 0.000 description 3
- 229920000858 Cyclodextrin Polymers 0.000 description 3
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 3
- 229930195725 Mannitol Natural products 0.000 description 3
- 229920000881 Modified starch Polymers 0.000 description 3
- 239000008272 agar Substances 0.000 description 3
- 235000010419 agar Nutrition 0.000 description 3
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 3
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 description 3
- 235000010418 carrageenan Nutrition 0.000 description 3
- 229920001525 carrageenan Polymers 0.000 description 3
- 235000010980 cellulose Nutrition 0.000 description 3
- 229920002678 cellulose Polymers 0.000 description 3
- 239000001913 cellulose Substances 0.000 description 3
- 238000002425 crystallisation Methods 0.000 description 3
- 230000008025 crystallization Effects 0.000 description 3
- 238000011161 development Methods 0.000 description 3
- IZEKFCXSFNUWAM-UHFFFAOYSA-N dipyridamole Chemical compound C=12N=C(N(CCO)CCO)N=C(N3CCCCC3)C2=NC(N(CCO)CCO)=NC=1N1CCCCC1 IZEKFCXSFNUWAM-UHFFFAOYSA-N 0.000 description 3
- 235000013402 health food Nutrition 0.000 description 3
- 239000000905 isomalt Substances 0.000 description 3
- 235000010439 isomalt Nutrition 0.000 description 3
- HPIGCVXMBGOWTF-UHFFFAOYSA-N isomaltol Natural products CC(=O)C=1OC=CC=1O HPIGCVXMBGOWTF-UHFFFAOYSA-N 0.000 description 3
- 239000000594 mannitol Substances 0.000 description 3
- 235000010355 mannitol Nutrition 0.000 description 3
- 229920000609 methyl cellulose Polymers 0.000 description 3
- 239000001923 methylcellulose Substances 0.000 description 3
- 235000010981 methylcellulose Nutrition 0.000 description 3
- 238000000465 moulding Methods 0.000 description 3
- 231100000957 no side effect Toxicity 0.000 description 3
- 229920001277 pectin Polymers 0.000 description 3
- 239000001814 pectin Substances 0.000 description 3
- 229920001282 polysaccharide Polymers 0.000 description 3
- 239000005017 polysaccharide Substances 0.000 description 3
- 150000004804 polysaccharides Chemical class 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 3
- 230000035943 smell Effects 0.000 description 3
- 235000002639 sodium chloride Nutrition 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 description 2
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical group CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 2
- SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 description 2
- 244000286663 Ficus elastica Species 0.000 description 2
- 231100000111 LD50 Toxicity 0.000 description 2
- 235000004298 Tamarindus indica Nutrition 0.000 description 2
- 240000004584 Tamarindus indica Species 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- 230000002159 abnormal effect Effects 0.000 description 2
- 239000003513 alkali Substances 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 239000000679 carrageenan Substances 0.000 description 2
- 229940113118 carrageenan Drugs 0.000 description 2
- 235000015165 citric acid Nutrition 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 239000002131 composite material Substances 0.000 description 2
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 2
- 210000000887 face Anatomy 0.000 description 2
- 210000003811 finger Anatomy 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 235000008216 herbs Nutrition 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 229960001375 lactose Drugs 0.000 description 2
- 238000011031 large-scale manufacturing process Methods 0.000 description 2
- 231100000053 low toxicity Toxicity 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 235000010987 pectin Nutrition 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 239000004334 sorbic acid Substances 0.000 description 2
- 229940075582 sorbic acid Drugs 0.000 description 2
- 235000010199 sorbic acid Nutrition 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 2
- 235000000346 sugar Nutrition 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- PVNIQBQSYATKKL-UHFFFAOYSA-N tripalmitin Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCC PVNIQBQSYATKKL-UHFFFAOYSA-N 0.000 description 2
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 2
- LUEWUZLMQUOBSB-FSKGGBMCSA-N (2s,3s,4s,5s,6r)-2-[(2r,3s,4r,5r,6s)-6-[(2r,3s,4r,5s,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5s,6r)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@@H](O[C@@H]2[C@H](O[C@@H](OC3[C@H](O[C@@H](O)[C@@H](O)[C@H]3O)CO)[C@@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O LUEWUZLMQUOBSB-FSKGGBMCSA-N 0.000 description 1
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 229920000178 Acrylic resin Polymers 0.000 description 1
- 239000004925 Acrylic resin Substances 0.000 description 1
- 229920000936 Agarose Polymers 0.000 description 1
- 244000247812 Amorphophallus rivieri Species 0.000 description 1
- 235000001206 Amorphophallus rivieri Nutrition 0.000 description 1
- 206010002660 Anoxia Diseases 0.000 description 1
- 241000976983 Anoxia Species 0.000 description 1
- 206010008479 Chest Pain Diseases 0.000 description 1
- 206010052895 Coronary artery insufficiency Diseases 0.000 description 1
- HEBKCHPVOIAQTA-QWWZWVQMSA-N D-arabinitol Chemical compound OC[C@@H](O)C(O)[C@H](O)CO HEBKCHPVOIAQTA-QWWZWVQMSA-N 0.000 description 1
- 208000012239 Developmental disease Diseases 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- 241001411320 Eriogonum inflatum Species 0.000 description 1
- 206010017577 Gait disturbance Diseases 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 229920002581 Glucomannan Polymers 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 229920002527 Glycogen Polymers 0.000 description 1
- 229920002907 Guar gum Polymers 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
- 229920001479 Hydroxyethyl methyl cellulose Polymers 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- 206010021143 Hypoxia Diseases 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 229920002752 Konjac Polymers 0.000 description 1
- 229920000161 Locust bean gum Polymers 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 1
- 239000004368 Modified starch Substances 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- MUPFEKGTMRGPLJ-RMMQSMQOSA-N Raffinose Natural products O(C[C@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](O[C@@]2(CO)[C@H](O)[C@@H](O)[C@@H](CO)O2)O1)[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 MUPFEKGTMRGPLJ-RMMQSMQOSA-N 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical class [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- MUPFEKGTMRGPLJ-UHFFFAOYSA-N UNPD196149 Natural products OC1C(O)C(CO)OC1(CO)OC1C(O)C(O)C(O)C(COC2C(C(O)C(O)C(CO)O2)O)O1 MUPFEKGTMRGPLJ-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 150000005215 alkyl ethers Chemical class 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- 230000007953 anoxia Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 235000013877 carbamide Nutrition 0.000 description 1
- 229960001631 carbomer Drugs 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 208000035850 clinical syndrome Diseases 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 239000008298 dragée Substances 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 229940046240 glucomannan Drugs 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 235000001727 glucose Nutrition 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 150000002333 glycines Chemical class 0.000 description 1
- 229940096919 glycogen Drugs 0.000 description 1
- 235000010417 guar gum Nutrition 0.000 description 1
- 239000000665 guar gum Substances 0.000 description 1
- 229960002154 guar gum Drugs 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 1
- 239000001341 hydroxy propyl starch Substances 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 229940071826 hydroxyethyl cellulose Drugs 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000013828 hydroxypropyl starch Nutrition 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 239000013067 intermediate product Substances 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 208000028867 ischemia Diseases 0.000 description 1
- 230000000302 ischemic effect Effects 0.000 description 1
- 235000015110 jellies Nutrition 0.000 description 1
- 239000008274 jelly Substances 0.000 description 1
- 235000010485 konjac Nutrition 0.000 description 1
- 239000000252 konjac Substances 0.000 description 1
- 210000004932 little finger Anatomy 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 235000010420 locust bean gum Nutrition 0.000 description 1
- 239000000711 locust bean gum Substances 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 238000007726 management method Methods 0.000 description 1
- 239000002398 materia medica Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 208000030159 metabolic disease Diseases 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 235000019426 modified starch Nutrition 0.000 description 1
- 208000031225 myocardial ischemia Diseases 0.000 description 1
- 210000004165 myocardium Anatomy 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 229960000292 pectin Drugs 0.000 description 1
- 238000005325 percolation Methods 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 230000007096 poisonous effect Effects 0.000 description 1
- 229960000502 poloxamer Drugs 0.000 description 1
- 229920001983 poloxamer Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229910052573 porcelain Inorganic materials 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000003014 reinforcing effect Effects 0.000 description 1
- 230000003578 releasing effect Effects 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 238000007560 sedimentation technique Methods 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- RYYKJJJTJZKILX-UHFFFAOYSA-M sodium octadecanoate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC([O-])=O RYYKJJJTJZKILX-UHFFFAOYSA-M 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 239000001384 succinic acid Substances 0.000 description 1
- 239000007940 sugar coated tablet Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 238000002636 symptomatic treatment Methods 0.000 description 1
- 230000026676 system process Effects 0.000 description 1
- 230000035922 thirst Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 229960001947 tripalmitin Drugs 0.000 description 1
- 238000003809 water extraction Methods 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The present invention provides a medicine for treating coronary artery disease and angina pectoris. The present invention overcomes the defects that the auxiliary materials of present drop pills have low pure natural degree, present common auxiliary materials chemically synthesized are not in food additive catalogues of certain countries, and the present drop pills have bad taste. The present invention is a medicinal preparation with high natural degree, high safety and low toxic side effect.
Description
Technical field
The present invention relates to field of medicaments, particularly, relating to Chinese medicine is treatment coronary heart disease, the anginal preparation that raw material is made.
Background technology
Coronary heart disease also claims ischemic heart desease, since its sickness rate height, the mortality rate height, and the healthy of the mankind in serious harm, thereby b referred to as " the first human killers ".Angina pectoris is a coronary insufficiency, and cardiac muscle is rapid, of short duration ischemia and the caused clinical syndrome of anoxia.Angina pectoris is the coronary heart disease common sympton, be more common in more than 40 years old in, the old people, the male is more than the women.Angina pectoris usually occurs in fatigue, heavy meal, catch cold and when excited, vexed pain, squeezing pain or constriction that the right occurrence scope of metosteon is not clear, and pain is shoulder, middle finger, the third finger and little finger of toe radiation to the right.At present, it is more to be used for the treatment for the treatment of coronary heart disease and angina pectoris, though Western medicine is rapid-action, curative effect is determined, but the influence of its toxic and side effects, make the patient when curing a kind of disease, the misery that faces other be arranged, and present most of Chinese medicine preparation ubiquity curative effect instability, curative effect is low, onset is slow, consumption is many shortcoming.
The synthetic chemical substance that modern medicine is commonly used has spreaded all over each corner of human lives, chemical synthetic drug becomes the main flow of medicine, yet, appearance along with multiple difficult serious symptom miscellaneous diseases, western medical treatment presents imperfect, the human lives and the healthy reality and the up-to-date successes achieved in research have all proposed query to this situation, particularly along with the continuous appearance of chemical drugs toxic and side effects, the change of spectrum of disease and conversion of medical, make modern medicine be subjected to unprecedented challenge, and people also place hope in the application and development of traditional medicine on gradually.Advocate back to nature, pay attention to plant amedica use, hanker after traditional remedies, the trend of advocating natural drug forms, making full use of natural materials is human best selections.
At present, in the world, natural drug all has certain market, along with people increasing and the aging of population to the health requirements level of understanding, sub-health stateization, people thirst for back to nature more, the problem of utilize the high Drug therapy of pure natural degree, preventing some chemical synthetic drugs cann't be solved, so the background that exceeds its original traditional national culture has been expanded in the application of natural plant.From natural drug, seek the little and inexpensive medicine of side effect and become the target that countries in the world pharmaceutical manufacturer is chased.The European Community has carried out unified legislation to medical herbs, state medical herbs status such as Canada and Australia have legalized, U.S. government has also drafted the plant amedica management method, the compound recipe mix preparation that begins to accept natural drug is as curative, and these provide good international environment for Chinese medicine enters international medical market as curative.On the other hand, along with the quickening of global economic integration progress, particularly China becomes a full member of WTO, and Chinese Medicine market incorporates the breadth and depth of international medical big market and will further aggravate.Face the enormous impact of Asian countries's traditional medicine product such as the keen competition of powerful transnational medical group and Japan, Korea S, India, Thailand and European countries' plant amedica such as Germany, France, numerous products that China's Chinese medicine produces are owing to still can not meet the standard of international medical market and requirement and being kept outside of the door.
Expansion and human back to nature requirement along with the market global range, use the low medicine of toxic and side effects, especially pure natural medical more and more becomes people's first-selection, dropping pill formulation be a kind of have efficient, quick-acting new medicine preparations, it has overcome the shortcoming and deficiency of Chinese medicine preparation in the past, but present dropping pill formulation generally faces following problem: 1, drop pill adjuvant pure natural degree is not high: at present, drop pill substrate adjuvant mostly is synthetic, natural degree is lower, the searching of new alternative substrate adjuvant, the searching of the alternative substrate adjuvant that particularly natural degree is high and preparation technology thereof determine, it is again very difficult thing, because the required preparation condition of at present common possible natural substrates adjuvant succedaneum is very harsh, it all is to influence the key that drop pill prepares molding that adjuvant temperature and drop pill thereof drip the system condition.The too high then viscosity of adjuvant melt temperature is low, and poor plasticity is though the adjuvant melt temperature is crossed lowplastcity by force, but drop pill has shortcomings such as easily sticking ball, distortion, therefore, seek pure natural degree height, and the adjuvant that is suitable for substituting existing drop pill substrate is a very job of hardships.2, the drop pill outlet encounters problems: along with expanding economy, more and more internationalize in market, China is also just making great efforts to adapt to this trend, present Chinese medicine dripping pills preparation as health food, successful export to many countries, but also face many problems at present, because different countries is different to the approval of the selected adjuvant of Chinese medicine dropping pill formulation, especially industrial flourishing Europe, more strict to food adjuvant and medical auxiliary materials, and as the selected chemosynthesis adjuvant (as Polyethylene Glycol) of the dropping pill formulation of health food outlet not in the catalogue of some national food additive, it is very unfavorable that this moves towards the international market to the Chinese medicine dropping pill formulation, becomes the stumbling-block that Chinese medicine enters the international market, therefore, seek the new of one or more, can be particularly important, also very urgent for the substrate adjuvant that the international market is accepted.3, the shortcoming of mouthfeel and onset speed: the mouthfeel of Chinese medicine and preparation thereof is relatively poor to be the big characteristics of one, people when taking some drugs to the frightened of disagreeable taste that medicine had even be better than fear far away to disease, What is more, some patients are because can not overcome the poor taste of Chinese medicine or its preparation or abnormal smells from the patient and abandon the treatment of Chinese medicine, though can improve mouthfeel as medicine being made capsule or sugar coated tablet, reducing stimulates, but disintegration rate prolongs, be unfavorable for the rapid onset of medicine, to some disease, particularly need the disease of the rapid onset of medicine inapplicable.4, the preparation process difficulty of drop pill suitability for industrialized production: in the replacement process of dropping pill formulation adjuvant, determining of the preparation process of its suitability for industrialized production is very difficult something, as the ratio of the melt temperature of substrate adjuvant, the proportioning of dripping system temperature, adjuvant and medicine, dropper bore, condensing agent etc. all are the factors that influence drop pill, therefore, the replacement of substrate and to be suitable for suitability for industrialized production be a job consuming time, as to expend substantial contribution.
In order to change drop pill substrate adjuvant for a long time based on the situation of chemosynthesis adjuvant, it is low to solve the pure natural degree that present drop pill substrate faced, and can not satisfy more and more that people require back to nature, take low toxicity, the problem of the pure natural medical that has no side effect; Also can solve some problems that Chinese medicine preparation, particularly dropping pill formulation are run in exit procedure, strengthen the competitiveness of international market; The present invention has invented the pure Chinese medicine dripping pills preparation that a kind of toxic and side effects is low, evident in efficacy, moderate, adapt to industrialized great production by a large amount of tests and the research of preparation process.
Summary of the invention
The purpose of this invention is to provide a kind of treatment coronary heart disease, anginal medicine with the preparation of new type natural substrate adjuvant.
Another object of the present invention provides a kind of preparation method for the treatment of coronary heart disease, angina drug preparation.
The present invention is the new pharmacological action that the qi-blood relationship theory learned according to Chinese traditional medicine and modern medicine are found various institutes of Chinese materia medica, according to " symptomatic treatment in acute condition, radical treatment in chronic case; set upright based on reinforcing; " leading to " just must not hinder, " benefit " must not be detained, treating both the principal and secondary aspects of a disease.The medicine of producing according to this method has late result again, and finally reaches the healing purpose the existing short term effect of the treatment of coronary heart disease, and generation without any side effects.New medium adjuvant of the present invention is resulting by a large amount of tests, have pure natural property height, toxic and side effects little, take that mouthfeel is good, the acceptant characteristics of patient, be the direction of following substrate adjuvant development.The selected substrate adjuvant of the present invention is resulting by a large amount of tests, it is little to have molecular weight, soluble in water, and molten diffusing speed is faster, pure natural degree height, toxic and side effects is lower, and can reduce the medicine irritation abnormal smells from the patient, has the oral cavity of improvement acid-base value during the buccal of oral cavity, improve the characteristics of oral cavity smell, the used substrate adjuvant of the present invention is the agent of food sedan-chair flavor, takes that mouthfeel is good, the acceptant characteristics of patient, is the direction of following substrate adjuvant development.
The consumption of drug component of the present invention and the selection of adjuvant thereof also grope to sum up to draw through the inventor in a large number, each amounts of components all has curative effect preferably in following ranges: 25～75 parts of Styrax, 50～160 parts of Borneolum Syntheticums, 50～160 parts of Olibanums, 105～320 parts in Lignum Santali Albi, 105～320 parts of Radix Aristolochiaes, appropriate amount of auxiliary materials is made, wherein adjuvant comprises filler and plasticity substrate, said filler is selected from the natural adjuvant of following one or more plant origins: erythritol, sorbitol, fructose, D-ribonic acid-gamma lactone, arabitol, trehalose, D-ribose, low melting-point agarose, Lac, xylitol, Raffinose, glucose, malic acid, citric acid, isomalt, lactose, maltose etc., and they contain the water of crystallization chemical compound; Said plasticity substrate is selected from the natural adjuvant of following one or more plant origins: starch and derivant thereof, cellulose and derivant thereof, arabic gum, dextran, chitin, sesbania gum, carrageenan, Ficus elastica, Furcellaran, tragakanta, carrageenin, tamarind gum, pectin, xanthan gum, alginic acid and salt thereof, dextrin, cyclodextrin, agar, lactose; Described starch and derivant thereof such as pregelatinized Starch, modified starch, hydroxypropyl starch, carboxymethyl starch, described cellulose and derivant thereof such as methylcellulose, microcrystalline Cellulose, sodium carboxymethyl cellulose, hydroxypropyl emthylcellulose, cross-linking sodium carboxymethyl cellulose, hydroxyethylmethyl-cellulose, hydroxyethyl-cellulose, hydroxypropyl cellulose; Be chosen as 40～60 parts of the Styrax, 80～130 parts of Borneolum Syntheticums, 80～130 parts of Olibanums, 180～250 parts in Lignum Santali Albi, 180～250 parts of Radix Aristolochiaes, appropriate amount of auxiliary materials of preferred drug component consumption of the present invention and adjuvant thereof are made, filler adjuvant wherein is selected from following one or more the natural adjuvant of plant origin: sorbitol, xylitol, lactose, maltose, and they contain the water of crystallization chemical compound; Plasticity substrate wherein is selected from following one or more the natural adjuvant of plant origin: pregelatinized Starch, carboxymethyl starch, methylcellulose, sodium carboxymethyl cellulose, hydroxypropyl emthylcellulose, arabic gum, alginic acid, dextrin, cyclodextrin, agar, lactose; Be chosen as 50 parts of the Styrax, 105 parts of Borneolum Syntheticums, 105 parts of Olibanums, 210 parts in Lignum Santali Albi, 210 parts of Radix Aristolochiaes, appropriate amount of auxiliary materials of best drug component consumption of the present invention and adjuvant thereof are made, and filler adjuvant wherein is selected from following one or more the natural adjuvant of plant origin: xylitol, lactose; Plasticity substrate wherein is selected from following one or more the natural adjuvant of plant origin: starch, arabic gum.
Can also contain chemosynthesis adjuvant and animal origin adjuvant in the above-mentioned dressing, wherein filler comprises phenylglycol, hexadecanol, octadecanol, sodium stearate, tristerin, tripalmitin, carbamide, polyoxyethylene monostearate, polyoxyethylene alkyl ether; Wherein plasticity substrate comprises polyvinylpyrrolidone, crospolyvinylpyrrolidone, carbomer, polyvinyl alcohol, acrylic resin, poloxamer, gelatin.
In screening to above adjuvant, we find: plant colloid such as carrageenan, the tragakanta, pectin, agar, arabic gum, Ficus elastica, tamarind gum, locust bean gum, Pseudobulbus Bletillae (Rhizoma Bletillae) glue, guar gum, Konjac glucomannan, it is big that plant colloids such as POLY-karaya have viscosity, mobile poor, characteristics such as do not solidify after the condensation, and arabic gum has high dense low sticking character, can be mixed with the aqueous solution of 50% concentration and still have flowability, this is one of not available characteristics of other hydrophilic colloid, arabic gum has at high temperature, under the low concentration, can ooze, but not condensation, at low temperature, under the high concentration, be difficult for oozing, but characteristics such as energy condensation.Polysaccharide such as polysaccharide such as starch and derivant thereof (as gelling starch, carboxymethyl starch etc.), cellulose derivative (as methylcellulose, sodium carboxymethyl cellulose, hydroxypropyl emthylcellulose etc.), alginic acid, dextrin, cyclodextrin, lactose, in screening, find alginic acid have viscosity big, be the fruit jelly sample, dextrin has the colloid sample, characteristics such as lactose coagulability difference; And starch and derivant thereof are materials commonly used in the medical science adjuvant, thus in polysaccharide preferred starch and derivant thereof.Polyhydric alcohol such as sorbitol (88～102 ℃), xylitol (88～94.5 ℃), lactose (70～80 ℃), mannitol (166～169 ℃), maltose alcohol (135～140 ℃), isomalt polyhydric alcohol such as (98～103 ℃) screen, and find that it has following characteristics as drop pill substrate: sorbitol, lactose, isomalt are mobile poor; Mannitol, maltose alcohol fusing point are too high; The xylitol coagulability is poor slightly.After Preliminary screening, preferred xylitol, lactose, sorbitol in the selection of polyhydric alcohol, the best is an xylitol.Xylitol has following characteristics as drop pill substrate: in the time of 91 ℃, molten condition has appearred in xylitol, but not fusion fully, cooling rapidly, it separates out crystallization very soon, xylitol mixes the back good fluidity with extractum at certain proportion, can drip and can condensation, but be condensed into Powdered thing, loosely organized, the toughness extreme difference, that pinches is promptly broken.Organic acid and salt, alkali such as citric acid (100 ℃), sorbic acid (133 ℃), succinic acid (181～189 ℃), sodium acetate organic acid such as (58 ℃) and salt, alkali, its as drop pill substrate have fusing point too high, with Chinese medical concrete can't mixing etc. shortcoming.
Because of above single adjuvant existing shortcoming in as the drop pill preparation process, particularly we by above-mentioned Preliminary screening after, determine two kinds of adjuvants are used and screen: mainly be that above various adjuvants are carried out combined sorting, final determine following several: the plant colloid cooperates with the plant colloid, the cooperating of polyhydric alcohol and polyhydric alcohol, polyhydric alcohol and plant colloidally cooperate, the cooperating of the cooperating of xylitol and arabic gum, lactose and arabic gum, based on the composite auxiliary material of xylitol.Find preferred the cooperation to be xylitol, lactose and the compound use of other adjuvant, this kind combination has following characteristics: make up with mannitol: can drip not condensation; Make up with sorbic acid: both do not dissolve each other; Make up with lactose: can drip the energy condensation, but frangible; Make up with pomelo-pectin, tragakanta, sodium alginate: viscosity is big, can't drip; Make up with arabic gum: can drip, coagulability is poor slightly; Make up with dextrin: can drip, coagulability is poor slightly; Make up with starch: can drip, coagulability is also better.Determine that at last best of breed is that xylitol cooperates with arabic gum with starch, xylitol with starch, lactose.
At xylitol and starch, lactose and starch, in the research of xylitol and arabic gum combination, xylitol and starch Application of composite being prepared some required in the process of drop pill factors investigated, mainly is to the xylitol type, condensed fluid, condensate temperature influences the drop pill mouldability, xylitol and starch proportion influence mouldability, temperature is to the influence of drop pill mouldability, the extractum amount influences the drop pill mouldability, mixing time influences the drop pill mouldability, the dropper bore is to the influence of drop pill particle diameter, the formulation optimization of drop pill, the Preliminary Determination of drop pill, dissolve scattered time limit is investigated.Find that the solid xylitol has three types of powder, granular and crystallinity, and the easiest fusion of powder xylitol, again can fine dissolving be dispersed in the mixed liquor that starch, extractum forms, good fluidity, drippage is easy, and granular and crystalline xyhose alcohol is difficult for fusion, solubility property is also slightly poor, the mix flow that they and starch, extractum form is relatively poor, viscosity is very big, almost cannot drip, and therefore drips first-selected powder xylitol in the system process at drop pill.
At ratio of adjuvant molding is found in the sex research, in the combination of xylitol and starch, lactose and starch, xylitol and arabic gum, low melting point substrate adjuvant is 1: 0～1: 1.5 with the ratio of the weight of plasticity substrate adjuvant, be preferably 1: 0.1～1: 0.9, the best is 1: 0.1～1: 0.5.Low melting point substrate adjuvant of being formed within this scope and plasticity substrate adjuvant, the drug matrices fused solution all can ooze, and can condensation.Specific to each combination, xylitol is preferably 1: 0.2 with the ratio of the weight of starch～1: 0.3, and lactose is preferably 1: 0.2 with the ratio of the weight of starch～1: 0.3, and the ratio of the weight of xylitol and arabic gum is preferably 1: 0.2～and 1: 0.4.Find that in the research of temperature temperature is big especially to the influence of drop pill mouldability to the influence of drop pill mouldability, when temperature is too low, owing to the too big effect that oozes that influences drop pill of viscosity of substrate, when temperature is too high, not condensation of drop pill.Find that mixing time can have influence on the mouldability of drop pill in mixing time in to the sex research of drop pill molding, mixing time is too short, and mobile poor, influence oozes, and mixing time is oversize, influences the condensation of drop pill.Dripping under the system temperature, mixing time in 1～120 minute all can, suitable mixing time was at 10～30 minutes.Consider that mixing time can not be too short in the suitability for industrialized production, adopt the method that low temperature stirs for a long time, high temperature drips system.Find that in the research of dropper bore to the influence of drop pill particle diameter the dropper bore influences the size of drop pill and the flowability of fusion substrate, the system effect is dripped in influence.Drop pill diminishes and diminishes along with bore, but after 1.4 millimeters, along with the bore change of size that diminishes is not obvious, but the matrix flow reduction, system is dripped in influence.
So in the preparation method of preparation, medicine mixes mixing time with the substrate adjuvant be 10～30 minutes; The mixed heating and melting temperature of medicine and substrate adjuvant is 45～115 ℃, dripping the system temperature is 45～95 ℃, and liquid coolant is liquid paraffin, methyl-silicone oil or vegetable oil (Oleum Glycines, Semen Ricini wet goods), and the temperature of liquid coolant is-20～25 ℃, dropper mouth internal diameter is 1.0～4.0 millimeters; Preferred heating and melting temperature is 60～85 ℃, and dripping a system temperature is 60～85 ℃, and condensing agent is liquid paraffin, methyl-silicone oil, and the condensing agent temperature is 0～18 ℃, and the dropper bore is 1.1～3.5 millimeters, and the difference of dropper mouth external diameter and internal diameter is less for well; Best heating and melting temperature is that to make temperature be that 64 ℃, dropper bore are that 1.2～2.5 millimeters, condensing agent are 0 ℃ methyl-silicone oil to 64 ℃, droplet.
The substrate adjuvant of the best of the present invention is xylitol and starch, and xylitol is 1: 0.2～1: 0.3 with the ratio of the weight of starch; Or be lactose and starch, lactose is 1: 0.2～1: 0.3 with the ratio of the weight of starch; Or be xylitol and arabic gum, the ratio of the weight of xylitol and arabic gum is 1: 0.2～1: 0.4.
Xylitol is a kind of natural plant sweetening agent, approve through World Health Organization (WHO), xylitol is a kind of safest sweeting agent, countries in the world are extensive use of in fields such as food and oral-cavity articles, xylitol enters the help that need not insulin in the cell, when sugar utilizes obstacle, can not cause blood sugar increasing yet, can improve diabetics symptom, have the ketoplastic effect of powerful inhibition, can promote the generation of liver glycogen, directly infiltrate the Developmental and Metabolic Disorder that tissue is participated in metabolism, can be corrected protein, fat and steroid; Xylose is the internal metabolism intermediate product, and body has higher toleration to it.Clinical practice proves: the highest oral dosis tolerata can reach 220g every day, and intravenous drip every day can reach 100g.The oral 25700mg/Kg of median lethal dose(LD 50) (LD50) mice, quiet notes 6400mg/Kg, the quiet notes of rat 6200mg/Kg.
Medicine mesostroma adjuvant of the present invention and amount of drug are than can being the scope that allows on the galenic pharmacy, medicine described here can be that crude drug also can be the effective ingredient extract, in order to adapt to industrialized great production, the ratio range of mesostroma adjuvant of the present invention and medicine refers to the weight proportion of adjuvant and extract drugs extractum, and the substrate adjuvant is 1: 0.1～1: 1 with the ratio of the weight of drug extract; Preferred substrate adjuvant is 1: 0.1～1: 0.6 with the ratio of the weight of extract drugs extractum; Best substrate adjuvant is 1: 0.2～1: 0.4 with the ratio of the extraction extractum weight of medicine.
Medicine of the present invention can adopt the preparation of Chinese medicine preparation conventional method.The preparation of effective ingredient of the present invention can be adopted following method: water extraction, decoction and alcohol sedimentation technique, extraction, infusion process, percolation, reflux extraction, continuous backflow extraction method, macroreticular resin absorbing method preparation.For example, these crude drug pulverize mix homogeneously can be made powder takes after mixing it with water; Also can be with these medicines decocting together, the condensed water decocting liquid is made oral liquid then; But, preferably adopt following technology to extract, but this can not limit protection scope of the present invention to raw material in order to make each crude drug of this medicine better bring into play drug effect.
The preparation method of medicine of the present invention is as follows:
(a) it is standby to take by weighing 25～75 parts of each crude drug Styrax, 50～160 parts of Borneolum Syntheticums, 50～160 parts of Olibanums, 105～320 parts in Lignum Santali Albi, 105～320 parts of Radix Aristolochiaes by proportioning;
(b) Olibanum, Lignum Santali Albi, Radix Aristolochiae extract volatile oil, and volatile oil device is in addition collected, and is standby; Medicinal residues extract secondary with 60～95% alcohol heating reflux, and each 0.5～5 hour, filter and reclaim ethanol, be evaporated to relative density and be 1.10～1.40 thick paste, drying is pulverized, and is standby;
(c) in appropriate amount of auxiliary materials, add said extracted thing and Styrax, Borneolum Syntheticum, fully mix, mixture adds standby volatile oil at 45～115 ℃ of heating and meltings, stirs, mixing time is 1～120 minute, insulation is 1.0～4.0 millimeters at 45～95 ℃ of temperature following system, dropper bore, splashes in-20～25 ℃ liquid paraffin, methyl-silicone oil or the vegetable oil, make drop pill, promptly.
Preferred manufacturing procedure comprises the following steps:
(a) it is standby to take by weighing 40～60 parts of each crude drug Styrax, 80～130 parts of Borneolum Syntheticums, 80～130 parts of Olibanums, 180～25 parts in Lignum Santali Albi, 180～250 parts of Radix Aristolochiaes by proportioning;
(b) Olibanum, Lignum Santali Albi, Radix Aristolochiae extract volatile oil, and volatile oil device is in addition collected, and is standby; Medicinal residues extract secondary with 75～85% alcohol heating reflux, and each 1～3 hour, filter and reclaim ethanol, be evaporated to relative density and be 1.20～135 thick paste, drying is pulverized, and is standby;
(c) add said extracted thing and Styrax, Borneolum Syntheticum in appropriate amount of auxiliary materials, fully mix, mixture is at 60～85 ℃ of heating and meltings, add standby volatile oil, stir, mixing time is 10～30 minutes, insulation, at 60～85 ℃ of temperature following system, dropper bore is 1.1～3.5 millimeters, splash in 0～18 ℃ the liquid paraffin, methyl-silicone oil, drip and make ball, to the greatest extent and wipe liquid coolant the drop pill drop that forms, back packing to be dried, promptly.
Best preparation method comprises the following steps:
(a) it is standby to take by weighing 50 parts of each crude drug Styrax, 105 parts of Borneolum Syntheticums, 105 parts of Olibanums, 210 parts in Lignum Santali Albi, 210 parts of Radix Aristolochiaes by proportioning;
(b) Olibanum, Lignum Santali Albi, Radix Aristolochiae extract volatile oil, and volatile oil device is in addition collected, and is standby; Medicinal residues extract secondary with 80% alcohol heating reflux, and each 2 hours, filter and reclaim ethanol, be evaporated to relative density and be 1.25～130 thick paste, drying is pulverized, and is standby;
(c) add said extracted thing and Styrax, Borneolum Syntheticum in appropriate amount of auxiliary materials, fully mix, mixture is at 64 ℃ of heating and meltings, add standby volatile oil again, stir, mixing time is 10～30 minutes, insulation, at 64 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splash in 0 ℃ the methyl-silicone oil, drip and make ball, to the greatest extent and wipe liquid coolant the drop pill drop that forms, back packing to be dried, promptly.
The best preparation method of medicine of the present invention is:
(a) it is standby to take by weighing 50 parts of each crude drug Styrax, 105 parts of Borneolum Syntheticums, 105 parts of Olibanums, 210 parts in Lignum Santali Albi, 210 parts of Radix Aristolochiaes by proportioning;
(b) Olibanum, Lignum Santali Albi, Radix Aristolochiae extract volatile oil, and volatile oil device is in addition collected, and is standby; Medicinal residues extract secondary with 80% alcohol heating reflux, and each 2 hours, filter and reclaim ethanol, be evaporated to relative density and be 1.25～130 thick paste, drying is pulverized, and is standby;
(c) be 1: 0.2～1: 0.3 xylitol and starch mixture to ratio an amount of, weight; Or the ratio of weight is 1: 0.2～1: 0.3 lactose and starch mixture; Or the ratio of weight is to add said extracted thing and Styrax, Borneolum Syntheticum in 1: 0.2～1: 0.4 xylitol and the arabic gum mixture, fully mixes, and mixture is at 64 ℃ of heating and meltings, add standby volatile oil again, stir, mixing time is 10～30 minutes, insulation, at 64 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splash in 0 ℃ the methyl-silicone oil, drip and make ball, to the greatest extent and wipe liquid coolant the drop pill drop that forms, back packing to be dried, promptly.
More than form when producing and to increase or to reduce according to corresponding ratio, as large-scale production can be unit with kilogram or with the ton, small-scale production can be unit with the gram also, and weight can increase or reduce, but the crude drug material weight proportion constant rate between each composition.
More than each single medicinal material, especially adjuvant drug, messenger drug or adjuvant drug and messenger drug in forming, can be replaced by suitable Chinese medicine individually or simultaneously with the identical property of medicine, effect, it is constant to replace back Chinese medicine preparation and drug effect thereof.
Medicine of the present invention can be determined usage and dosage according to patient's situation in use, but every day 1-3 time, and every day, each crude drug consumption was as the criterion with the state-promulgated pharmacopoeia dosage, was no more than the pharmacopeia ormal weight.
The drop pill that the present invention is prepared, conventional drop pill advantage is simple as preparing except having, steady quality, can make liquid medicine solidification, convenient drug administration, efficient, quick-acting, its biggest advantage is:
1, the selected adjuvant pure natural of the present invention degree height: the substrate adjuvant that employed substrate adjuvant derives from natural plants or originates based on natural plants among the present invention, selected substrate adjuvant is xylitol and starch or lactose and starch or xylitol and arabic gum, this substrate adjuvant has pure natural degree height, toxic and side effects is low, mouthfeel is good, dissolve scattered time limit is short, rapid-action, it is a kind of new medium adjuvant, can be used for substituting present chemosynthesis adjuvant, the drop pill made from this kind adjuvant, it is low to solve the pure natural degree that present drop pill substrate faced, and more and more can not satisfy people and require back to nature, take low toxicity, the problem of the pure natural medical that has no side effect.
2, some problems in the outlet of solution Chinese medicine: medicine of the present invention also can solve Chinese medicine preparation, some problems of in exit procedure, being run into of dropping pill formulation particularly, solve because different countries, especially the European countries of industry prosperity are to the difference identification of the selected adjuvant of Chinese medicine dropping pill formulation, overcome as the selected adjuvant Polyethylene Glycol of the dropping pill formulation of the health food outlet defective in some national food additive catalogue not, improve the Chinese medicine dripping pills preparation and move towards the international market, strengthen the competitiveness of international market.
3, solve the relatively poor problem of drop pill taste and further improve drug effect speed (dissolve scattered time limit): the medicinal dropping ball made from this kind substrate adjuvant of the present invention, can improve Chinese medicine preparation, the particularly present not good shortcoming of dropping pill formulation taste, improve mouthfeel, more easy for patients to accept, and the drop pill that adopts the selected adjuvant of medicine of the present invention to make has shorter dissolve scattered time limit, making drug effect faster, is the medicine that coronary heart disease, angina pectoris, myocardial ischemia are treated in a kind of onset faster.
4, higher safety and solve some problems in the drop pill storage process: the selected substrate of the present invention is not only additive, nutrient commonly used in the food industry, and can do medicinal, but do not see that it uses as the drug matrices adjuvant, therefore, with regard to substrate, be perfectly safe, have no side effect, a large amount of evidences, the drop pill made from this adjuvant can reduce shortcomings such as effective ingredient effective ingredient in storage process is separated out, the sticking ball of drop pill, easy moisture absorption deliquescing, but the big production of suitability for industrialized.
The present invention is under instruction of Chinese Medicine theory, preparation technology's test that process is a large amount of and pharmacology, the resulting preparation of pharmacodynamics test.The present invention is evident in efficacy, has the chest stuffiness relieving of regulating the flow of vital energy, and the effect of pain relieving is used for the treatment of diseases such as angina pectoris, chest distress clinically.Reasonable recipe of the present invention, poisonous side effect of medicine is low, it is bigger to have overcome western medicine angina pectoris toxic and side effects, and the Chinese medicine curative effect is low, flavour of a drug are many or the adjuvant toxic and side effects is big, the shortcoming of incompatibility large-scale production, is a kind of economy, material benefit, the definite anginal medicine of treatment of curative effect.
In order to understand the present invention better, dissolve scattered time limit, the weight differential comparative test with GUANXIN SUHE DIWAN illustrates advantage of the present invention below.
Test example 1: dissolve scattered time limit, weight differential contrast experiment's example
In vitro tests
The present invention be that the GUANXIN SUHE DIWAN that adjuvant is made compares with the Polyethylene Glycol, by measuring index such as dissolve scattered time limit, investigate its good releasing effect; Whether by weight differential, it is ripe to investigate its preparation technology, whether is fit to suitability for industrialized production.
1. test medication: the new substrate GUANXIN SUHE DIWAN of the present invention (newly) is provided by the Jinshili Medicine Research ﹠. Development Co., Ltd., Tianjin; With the Polyethylene Glycol is the GUANXIN SUHE DIWAN (old) that adjuvant is made, and Tongrentang Pharmaceutical Factory, Beijing produces.
2. method and result:
Dissolve scattered time limit: by " method is measured under this item of Chinese pharmacopoeia; The ball method of double differences is different: by " method is measured under this item of Chinese pharmacopoeia.Result of the test sees Table 1.
Three batches of GUANXIN SUHE DIWAN made from the new medium adjuvant of table 1 (newly) with the polyethylene glycol 6000 be GUANXIN SUHE DIWAN (old) dissolve scattered time limit made of adjuvant, weight differential relatively
Test data shows, the dissolve scattered time limit of new substrate GUANXIN SUHE DIWAN is that the GUANXIN SUHE DIWAN made of adjuvant is few with the Polyethylene Glycol, and the ball method of double differences of new and old substrate GUANXIN SUHE DIWAN is different all to be controlled in the pharmacopeia prescribed limit.Result of the test explanation, the molten diffusing speed of the GUANXIN SUHE DIWAN made from new substrate is faster, is more conducive to medicine and plays a role in the shortest time; The ball weight differential of new substrate GUANXIN SUHE DIWAN to be that the GUANXIN SUHE DIWAN made of adjuvant is similar with the Polyethylene Glycol, the ball method of double differences is different all to be controlled in the pharmacopeia prescribed limit, the difference not statistically significant illustrates the alternative present chemosynthesis adjuvant of this natural substrates adjuvant, but suitability for industrialized production.
Test example 2: the present invention with the polyethylene glycol 6000 be the sticking ball comparative observation of GUANXIN SUHE DIWAN soft durometer, drop pill that adjuvant is made
1. reagent: the new substrate GUANXIN SUHE DIWAN of the present invention (newly) is the GUANXIN SUHE DIWAN (old) that adjuvant is made with the Polyethylene Glycol.
2. method and result: three batches of the things of getting it filled are loaded in the porcelain vase respectively, and use the bottle stopper good seal.Putting it into the bottom has in the exsiccator of saturated Nacl (humidity 75%) solution, exsiccator is put into 40 ℃ of drying baker of constant temperature again, and timing sampling is observed situations such as drop pill soft durometer, the sticking ball of drop pill, the results are shown in Table 2.1, table 2.2.
Three batches in table 2.1 is that the GUANXIN SUHE DIWAN reserved sample observing that adjuvant is made compares with the polyethylene glycol 6000
Table 2.2: three batches of GUANXIN SUHE DIWAN made from the new medium adjuvant (newly) with the polyethylene glycol 6000 be GUANXIN SUHE DIWAN (old) character observation made of adjuvant relatively
Result of the test shows, new substrate GUANXIN SUHE DIWAN soft durometer changes and be that the GUANXIN SUHE DIWAN made of adjuvant is similar, strong slightly with the Polyethylene Glycol; The sticking ball variation of new substrate GUANXIN SUHE DIWAN, firmness change and be that the GUANXIN SUHE DIWAN made of adjuvant is similar with the Polyethylene Glycol.Presentation of results, the sticking ball of the GUANXIN SUHE DIWAN that new and old substrate adjuvant is made changes, firmness change is similar, and the alternative present chemosynthesis adjuvant of this natural substrates adjuvant is described, but suitability for industrialized production.
The specific embodiment
Embodiment 1
A: get Styrax 50g, Borneolum Syntheticum 105g, Olibanum (system) 105g, Lignum Santali Albi 210g, Radix Aristolochiae 210g, 100g is standby for xylitol 400g starch;
B: the above five tastes, except that Styrax, Borneolum Syntheticum, three flavors such as all the other Olibanums extract volatile oil, and medicinal residues extract secondary, each 2 hours with 80% alcohol heating reflux, filter, filtrate recycling ethanol is 1.25～1.30 thick paste to not having the alcohol flavor, being evaporated to relative density, drying, be ground into fine powder, standby;
C: to xylitol close with starch mixture in add said extracted thing and Styrax, Borneolum Syntheticum, fully mix, mixture is at 64 ℃ of heating and meltings, add standby volatile oil again, stir, mixing time is 10～30 minutes, insulation, at 64 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splash in 0 ℃ the methyl-silicone oil, make the 1000g drop pill, to the greatest extent and wipe liquid coolant the drop pill drop that forms, back packing to be dried, promptly.
Embodiment 2
A: get Styrax 50g, Borneolum Syntheticum 105g, Olibanum (system) 105g, Lignum Santali Albi 210g, Radix Aristolochiae 210g, lactose 416g, starch 84g are standby;
B: the above five tastes, except that Styrax, Borneolum Syntheticum, three flavors such as all the other Olibanums extract volatile oil, and medicinal residues extract secondary, each 2 hours with 80% alcohol heating reflux, filter, filtrate recycling ethanol is 1.25～1.30 thick paste to not having the alcohol flavor, being evaporated to relative density, drying, be ground into fine powder, standby;
C: add said extracted thing and Styrax, Borneolum Syntheticum in lactose and starch mixture, fully mix, mixture is at 60～68 ℃ of heating and meltings, add standby volatile oil again, stir, mixing time is 10～30 minutes, insulation, at 60～68 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splash in 0～8 ℃ the methyl-silicone oil, make the 1000g drop pill, to the greatest extent and wipe liquid coolant the drop pill drop that forms, back packing to be dried, promptly.
Embodiment 3
A: get Styrax 50g, Borneolum Syntheticum 105g, Olibanum (system) 105g, Lignum Santali Albi 210g, Radix Aristolochiae 210g, xylitol 357g, arabic gum 143g are standby;
B: the above five tastes, except that Styrax, Borneolum Syntheticum, three flavors such as all the other Olibanums extract volatile oil, and medicinal residues extract secondary with 80% alcohol heating reflux, each 2 hours, filter, filtrate recycling ethanol is to there not being the alcohol flavor, be evaporated to relative density and be 1.25～1.30 thick paste, drying, it is standby to be ground into fine powder;
C: add said extracted thing and Styrax, Borneolum Syntheticum in xylitol and arabic gum mixture, fully mix, mixture is at 62～66 ℃ of heating and meltings, add standby volatile oil again, stir, mixing time is 10～30 minutes, insulation, at 62～66 ℃ of temperature following system, dropper bore is 1.21～2.5 millimeters, splash in 0 ℃ the methyl-silicone oil, make the 1000g drop pill, to the greatest extent and wipe liquid coolant the drop pill drop that forms, back packing to be dried, promptly.
Embodiment 4
A: get Styrax 50g, Borneolum Syntheticum 105g, Olibanum (system) 105g, Lignum Santali Albi 210g, Radix Aristolochiae 210g, xylitol 105g, starch 21g, alginic acid 56g is standby;
B: the above five tastes, except that Styrax, Borneolum Syntheticum, three flavors such as all the other Olibanums extract volatile oil, and medicinal residues extract secondary, each 2 hours with 80% alcohol heating reflux, filter, filtrate recycling ethanol is 1.25～1.30 thick paste to not having the alcohol flavor, being evaporated to relative density, drying, be ground into fine powder, standby;
C: add said extracted thing and Styrax, Borneolum Syntheticum in xylitol, starch and alginic acid mixture, fully mix, mixture is at 80～85 ℃ of heating and meltings, add standby volatile oil again, stir, mixing time is 5～10 minutes, insulation, at 62～68 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splash in 0～10 ℃ the methyl-silicone oil, make the 500g drop pill, to the greatest extent and wipe liquid coolant the drop pill drop that forms, back packing to be dried, promptly.
Embodiment 5
A: get Styrax 26g, Borneolum Syntheticum 50g, Olibanum (system) 320g, Lignum Santali Albi 210g, Radix Aristolochiae 250g, xylitol 510g, arabic gum 95g, chitin 105g is standby;
B: the above five tastes, except that Styrax, Borneolum Syntheticum, three flavors such as all the other Olibanums extract volatile oil, and medicinal residues extract secondary, each 3 hours with 70% alcohol heating reflux, filter, filtrate recycling ethanol is 1.15～1.20 thick paste to not having the alcohol flavor, being evaporated to relative density, drying, be ground into fine powder, standby;
C: add said extracted thing and Styrax, Borneolum Syntheticum in xylitol and arabic gum, fully mix, mixture is at 60～85 ℃ of heating and meltings, add standby volatile oil, stir, mixing time is 10～30 minutes, insulation, at 60～85 ℃ of temperature following system, dropper bore is 1.1～3.5 millimeters, splash in 0～18 ℃ the methyl-silicone oil, drip and make the 1000g ball, to the greatest extent and wipe liquid coolant the drop pill drop that forms, back packing to be dried, promptly.
Embodiment 6
A: get Styrax 60g, Borneolum Syntheticum 80g, Olibanum (system) 80g, Lignum Santali Albi 320g, Radix Aristolochiae 105g, erythritol 230g, sorbitol 320g, fructose 15g, sesbania gum 65g are standby;
B: the above five tastes, except that Styrax, Borneolum Syntheticum, three flavors such as all the other Olibanums extract volatile oil, and medicinal residues extract secondary, each 2.5 hours with 75% alcohol heating reflux, filter, filtrate recycling ethanol is 1.25～1.30 thick paste to not having the alcohol flavor, being evaporated to relative density, drying, be ground into fine powder, standby;
C: add said extracted thing and Styrax, Borneolum Syntheticum in erythritol, sorbitol, fructose and sesbania gum mixture, fully mix, mixture is at 60～85 ℃ of heating and meltings, add standby volatile oil, stir, mixing time is 10～30 minutes, insulation, at 60～85 ℃ of temperature following system, dropper bore is 1.1～3.5 millimeters, splash in 0～18 ℃ the liquid paraffin, drip and make the 1000g ball, to the greatest extent and wipe liquid coolant the drop pill drop that forms, back packing to be dried, promptly.
Embodiment 7
A: get Styrax 55g, Borneolum Syntheticum 50g, Olibanum (system) 105g, Lignum Santali Albi 200g, Radix Aristolochiae 210g, xylitol 417g, starch 83g are standby;
B: the above five tastes, except that Styrax, Borneolum Syntheticum, three flavors such as all the other Olibanums extract volatile oil, and medicinal residues extract secondary, each 2 hours with 65% alcohol heating reflux, filter, filtrate recycling ethanol is 1.10～1.20 thick paste to not having the alcohol flavor, being evaporated to relative density, drying, be ground into fine powder, standby;
C: add said extracted thing and Styrax, Borneolum Syntheticum in xylitol and starch, fully mix, mixture is at 60～85 ℃ of heating and meltings, add standby volatile oil, stir, mixing time is 10～30 minutes, insulation, at 60～85 ℃ of temperature following system, dropper bore is 1.1～3.5 millimeters, splash in 0～18 ℃ the liquid paraffin, methyl-silicone oil, drip and make the 1000g ball, to the greatest extent and wipe liquid coolant the drop pill drop that forms, back packing to be dried, promptly.
Embodiment 8
A: get Styrax 75g, Borneolum Syntheticum 160g, Olibanum (system) 160g, Lignum Santali Albi 130g, Radix Aristolochiae 180g xylitol 650g, arabic gum 125g are standby;
B: the above five tastes, except that Styrax, Borneolum Syntheticum, three flavors such as all the other Olibanums extract volatile oil, and medicinal residues extract secondary, each 4 hours with 85% alcohol heating reflux, filter, filtrate recycling ethanol is 1.30～1.35 thick paste to not having the alcohol flavor, being evaporated to relative density, drying, be ground into fine powder, standby;
C: add said extracted thing and Styrax, Borneolum Syntheticum in xylitol and arabic gum, fully mix, mixture is at 60～85 ℃ of heating and meltings, add standby volatile oil, stir, mixing time is 10～30 minutes, insulation, at 60～85 ℃ of temperature following system, dropper bore is 1.1～3.5 millimeters, splash in 10～18 ℃ the liquid paraffin, drip and make the 1000g ball, to the greatest extent and wipe liquid coolant the drop pill drop that forms, back packing to be dried, promptly.
Embodiment 9
A: get Styrax 60g, Borneolum Syntheticum 100g, Olibanum (system) 165g, Lignum Santali Albi 180g, Radix Aristolochiae 210g, lactose 425g, D-ribose 115g, starch 241g are standby;
B: the above five tastes, except that Styrax, Borneolum Syntheticum, three flavors such as all the other Olibanums extract volatile oil, and medicinal residues extract secondary, each 2.5 hours with 90% alcohol heating reflux, filter, filtrate recycling ethanol is 1.20～1.30 thick paste to not having the alcohol flavor, being evaporated to relative density, drying, be ground into fine powder, standby;
C: add said extracted thing and Styrax, Borneolum Syntheticum in lactose, D-ribose and starch, fully mix, mixture is at 60～85 ℃ of heating and meltings, add standby volatile oil, stir, mixing time is 10～30 minutes, insulation, at 60～85 ℃ of temperature following system, dropper bore is 1.1～3.5 millimeters, splash in 5～15 ℃ the methyl-silicone oil, drip and make the 1000g ball, to the greatest extent and wipe liquid coolant the drop pill drop that forms, back packing to be dried, promptly.
Embodiment 10
A: get Styrax 60g, Borneolum Syntheticum 100g, Olibanum (system) 85g, Lignum Santali Albi 150g, Radix Aristolochiae 130g, 120g is standby for xylitol 600g starch;
B: the above five tastes, except that Styrax, Borneolum Syntheticum, three flavors such as all the other Olibanums extract volatile oil, and medicinal residues extract secondary, each 2 hours with 70% alcohol heating reflux, filter, filtrate recycling ethanol is 1.25～1.30 thick paste to not having the alcohol flavor, being evaporated to relative density, drying, be ground into fine powder, standby;
C: to xylitol close with starch mixture in add said extracted thing and Styrax, Borneolum Syntheticum, fully mix, mixture is at 60～70 ℃ of heating and meltings, add standby volatile oil again, stir, mixing time is 20～30 minutes, insulation, at 60～70 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splash in 10 ℃ the methyl-silicone oil, make the 1000g drop pill, to the greatest extent and wipe liquid coolant the drop pill drop that forms, back packing to be dried, promptly.
Embodiment 11
A: get Styrax 50g, Borneolum Syntheticum 105g, Olibanum (system) 105g, Lignum Santali Albi 210g, Radix Aristolochiae 210g, lactose 384g, starch 116g are standby;
B: the above five tastes, except that Styrax, Borneolum Syntheticum, three flavors such as all the other Olibanums extract volatile oil, and medicinal residues extract secondary, each 2 hours with 60% alcohol heating reflux, filter, filtrate recycling ethanol is 1.25～1.30 thick paste to not having the alcohol flavor, being evaporated to relative density, drying, be ground into fine powder, standby;
C: add said extracted thing and Styrax, Borneolum Syntheticum in lactose and starch mixture, fully mix, mixture is at 60～68 ℃ of heating and meltings, add standby volatile oil again, stir, mixing time is 10～30 minutes, insulation, at 60～68 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splash in 0～8 ℃ the methyl-silicone oil, make the 1000g drop pill, to the greatest extent and wipe liquid coolant the drop pill drop that forms, back packing to be dried, promptly.
Embodiment 12
A: get Styrax 100g, Borneolum Syntheticum 105g, Olibanum (system) 105g, Lignum Santali Albi 300g, Radix Aristolochiae 300g, xylitol 400g, arabic gum 100g are standby;
B: the above five tastes, except that Styrax, Borneolum Syntheticum, three flavors such as all the other Olibanums extract volatile oil, and medicinal residues extract secondary with 75% alcohol heating reflux, each 2 hours, filter, filtrate recycling ethanol is to there not being the alcohol flavor, be evaporated to relative density and be 1.25～1.30 thick paste, drying, it is standby to be ground into fine powder;
C: add said extracted thing and Styrax, Borneolum Syntheticum in xylitol and arabic gum mixture, fully mix, mixture is at 62～66 ℃ of heating and meltings, add standby volatile oil again, stir, mixing time is 10～30 minutes, insulation, at 62～66 ℃ of temperature following system, dropper bore is 1.21～2.5 millimeters, splash in 0～10 ℃ the methyl-silicone oil, make the 1000g drop pill, to the greatest extent and wipe liquid coolant the drop pill drop that forms, back packing to be dried, promptly.
Embodiment 13
A: get Styrax 75g, Borneolum Syntheticum 125g, Olibanum (system) 100g, Lignum Santali Albi 200g, Radix Aristolochiae 105g, xylitol 405g, starch 95g are standby;
B: the above five tastes, except that Styrax, Borneolum Syntheticum, three flavors such as all the other Olibanums extract volatile oil, and medicinal residues extract secondary, each 2 hours with 60% alcohol heating reflux, filter, filtrate recycling ethanol is 1.25～1.30 thick paste to not having the alcohol flavor, being evaporated to relative density, drying, be ground into fine powder, standby;
C: add said extracted thing and Styrax, Borneolum Syntheticum in xylitol, starch mixture, fully mix, mixture is at 80～85 ℃ of heating and meltings, add standby volatile oil again, stir, mixing time is 5～10 minutes, insulation, at 62～68 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splash in 0～10 ℃ the methyl-silicone oil, make the 100g drop pill, to the greatest extent and wipe liquid coolant the drop pill drop that forms, back packing to be dried, promptly.
Embodiment 14
A: get Styrax 80g, Borneolum Syntheticum 65g, Olibanum (system) 300g, Lignum Santali Albi 180g, Radix Aristolochiae 180g, xylitol 385g, arabic gum 955g, chitin 105g is standby;
B: the above five tastes, except that Styrax, Borneolum Syntheticum, three flavors such as all the other Olibanums extract volatile oil, and medicinal residues extract secondary, each 3 hours with 70% alcohol heating reflux, filter, filtrate recycling ethanol is 1.15～1.20 thick paste to not having the alcohol flavor, being evaporated to relative density, drying, be ground into fine powder, standby;
C: add said extracted thing and Styrax, Borneolum Syntheticum in xylitol and arabic gum, fully mix, mixture is at 60～85 ℃ of heating and meltings, add standby volatile oil, stir, mixing time is 10～30 minutes, insulation, at 60～85 ℃ of temperature following system, dropper bore is 1.1～3.5 millimeters, splash in 0～18 ℃ the methyl-silicone oil, drip and make the 1000g ball, to the greatest extent and wipe liquid coolant the drop pill drop that forms, back packing to be dried, promptly.
Embodiment 15
A: get Styrax 80g, Borneolum Syntheticum 65g, Olibanum (system) 300g, Lignum Santali Albi 180g, Radix Aristolochiae 180g, xylitol 385g, chitin 105g are standby;
B: the above five tastes, except that Styrax, Borneolum Syntheticum, three flavors such as all the other Olibanums extract volatile oil, and medicinal residues extract secondary, each 3 hours with 70% alcohol heating reflux, filter, filtrate recycling ethanol is 1.15～1.20 thick paste to not having the alcohol flavor, being evaporated to relative density, drying, be ground into fine powder, standby;
C: in xylitol and chitin, add said extracted thing and Styrax, Borneolum Syntheticum, fully mix, mixture adds standby volatile oil at 45～115 ℃ of heating and meltings, stirs, mixing time is 1～120 minute, insulation is 1.0～4.0 millimeters at 45～95 ℃ of temperature following system, dropper bore, splashes in-20～25 ℃ liquid paraffin, methyl-silicone oil or the vegetable oil, make and drip the 1000g ball, promptly.
Claims (15)
1, a kind of medicine for the treatment of obstruction of qi in the chest and cardialgia, it is characterized in that it is to be made by 25～75 parts of Styrax, 50～160 parts of Borneolum Syntheticums, 50～160 parts of Olibanums, 105～320 parts in Lignum Santali Albi, 105～320 parts of Radix Aristolochiaes, appropriate amount of auxiliary materials, wherein adjuvant comprises filler and plasticity substrate, and said filler is selected from the natural adjuvant of following one or more plant origins: erythritol, sorbitol, fructose, trehalose, D-ribose, xylitol, lactose; Said plasticity substrate is selected from the natural adjuvant of following one or more plant origins: starch and derivant thereof, arabic gum, chitin, sesbania gum; Described filler is 1: 0.1～1: 0.5 with the ratio of the weight of plasticizer.
2, the medicine of treatment obstruction of qi in the chest and cardialgia as claimed in claim 1, it is characterized in that it is to be made by 40～60 parts of Styrax, 80～130 parts of Borneolum Syntheticums, 80～130 parts of Olibanums, 180～250 parts in Lignum Santali Albi, 180～250 parts of Radix Aristolochiaes, appropriate amount of auxiliary materials, filler adjuvant wherein is selected from following one or more the natural adjuvant of plant origin: xylitol, lactose; Plasticity substrate wherein is selected from following one or more the natural adjuvant of plant origin: starch, arabic gum, the weight ratio of described filler and plasticizer are 1: 0.1～1: 0.5.
3, the medicine of treatment obstruction of qi in the chest and cardialgia as claimed in claim 1 is characterized in that it is to be made by 50 parts of Styrax, 105 parts of Borneolum Syntheticums, 105 parts of Olibanums, 210 parts in Lignum Santali Albi, 210 parts of Radix Aristolochiaes, appropriate amount of auxiliary materials, and filler adjuvant wherein is selected from xylitol; Plasticizer is starch, alginic acid, and the weight ratio of described filler and plasticizer is 1: 0.3.
4, the medicine of treatment obstruction of qi in the chest and cardialgia as claimed in claim 1, it is characterized in that it is to be made by 25 parts of Styrax, 50 parts of Borneolum Syntheticums, 320 parts of Olibanums, 210 parts in Lignum Santali Albi, 250 parts of Radix Aristolochiaes, appropriate amount of auxiliary materials, filler adjuvant wherein is selected from xylitol, plasticizer is arabic gum, chitin; The weight ratio of described filler and plasticizer is 1: 0.4.
5, the medicine of treatment obstruction of qi in the chest and cardialgia as claimed in claim 1, it is characterized in that it is to be made by 60 parts of Styrax, 80 parts of Borneolum Syntheticums, 80 parts of Olibanums, 320 parts in Lignum Santali Albi, 105 parts of Radix Aristolochiaes, appropriate amount of auxiliary materials, filler adjuvant wherein is erythritol, sorbitol, fructose, and plasticizer is a sesbania gum; The weight ratio of described filler and plasticizer is 1: 0.1.
6, the medicine of treatment obstruction of qi in the chest and cardialgia as claimed in claim 1, it is characterized in that it is to be made by 60 parts of Styrax, 100 parts of Borneolum Syntheticums, 165 parts of Olibanums, 180 parts in Lignum Santali Albi, 210 parts of Radix Aristolochiaes, appropriate amount of auxiliary materials, filler adjuvant wherein is lactose, D-ribose, plasticizer is a starch, and the weight ratio of described filler and plasticizer is 1: 0.4.
7, the medicine of treatment obstruction of qi in the chest and cardialgia as claimed in claim 2 is characterized in that described adjuvant is xylitol and starch, and xylitol is 1: 0.2～1: 0.3 with the ratio of the weight of starch.
8, the medicine of treatment obstruction of qi in the chest and cardialgia as claimed in claim 2 is characterized in that described adjuvant is lactose and starch, and lactose is 1: 0.2～1: 0.3 with the ratio of the weight of starch.
9, the medicine of treatment obstruction of qi in the chest and cardialgia as claimed in claim 2 is characterized in that described adjuvant is xylitol and arabic gum, and the ratio of the weight of xylitol and arabic gum is 1: 0.2～1: 0.4.
10,, it is characterized in that the adjuvant and the ratio of the weight of extract drugs extractum are 1: 0.1～1: 1 as the medicine of any described treatment obstruction of qi in the chest and cardialgia of claim 1～6.
11,, it is characterized in that the adjuvant and the ratio of the weight of extract drugs extractum are 1: 0.1～1: 0.6 as the medicine of any described treatment obstruction of qi in the chest and cardialgia of claim 1～6.
12,, it is characterized in that the adjuvant and the ratio of the weight of extract drugs extractum are 1: 0.2～1: 0.4 as the medicine of any described treatment obstruction of qi in the chest and cardialgia of claim 1～6.
13, the preparation method of any described treatment obstruction of qi in the chest and cardialgia medicine of claim 1～12 is characterized in that this method comprises the steps:
(a) it is standby to get 25～75 parts of Styrax, 50～160 parts of Borneolum Syntheticums, 50～160 parts of Olibanums, 105～320 parts in Lignum Santali Albi, 105～320 parts of Radix Aristolochiaes;
(b) Olibanum, Lignum Santali Albi, Radix Aristolochiae extract volatile oil, and volatile oil device is in addition collected, and is standby; Medicinal residues extract secondary with 60～95% alcohol heating reflux, and each 0.5～5 hour, filter and reclaim ethanol, be evaporated to relative density and be 1.10～1.40 thick paste, drying is pulverized, and is standby;
(c) in appropriate amount of auxiliary materials, add said extracted thing and Styrax, Borneolum Syntheticum, fully mix, mixture adds standby volatile oil at 45～115 ℃ of heating and meltings, stirs, mixing time is 1～120 minute, insulation is 1.0～4.0mm at 45～95 ℃ of temperature following system, dropper bore, splashes in-20～25 ℃ liquid paraffin, methyl-silicone oil or the vegetable oil, make drop pill, promptly.
14, the preparation method of treatment obstruction of qi in the chest and cardialgia medicine as claimed in claim 13 is characterized in that this method comprises the steps:
(a)) it is standby to get 40～60 parts of Styrax, 80～130 parts of Borneolum Syntheticums, 80～130 parts of Olibanums, 180～25 parts in Lignum Santali Albi, 180～250 parts of Radix Aristolochiaes;
(b) Olibanum, Lignum Santali Albi, Radix Aristolochiae extract volatile oil, and volatile oil device is in addition collected, and is standby; Medicinal residues extract secondary with 75～85% alcohol heating reflux, and each 1～3 hour, filter and reclaim ethanol, be evaporated to relative density and be 1.20～135 thick paste, drying is pulverized, and is standby;
(c) add said extracted thing and Styrax, Borneolum Syntheticum in appropriate amount of auxiliary materials, fully mix, mixture is at 60～85 ℃ of heating and meltings, add standby volatile oil, stir, mixing time is 10～30 minutes, insulation, at 60～85 ℃ of temperature following system, dropper bore is 1.1～3.5mm, splash in 0～18 ℃ the liquid paraffin, methyl-silicone oil, drip and make ball, to the greatest extent and wipe liquid coolant the drop pill drop that forms, back packing to be dried, promptly.
15, the preparation method of treatment obstruction of qi in the chest and cardialgia medicine as claimed in claim 13 is characterized in that this method comprises the steps:
(a) it is standby to get 50 parts of Styrax, 105 parts of Borneolum Syntheticums, 105 parts of Olibanums, 210 parts in Lignum Santali Albi, 210 parts of Radix Aristolochiaes;
(b) Olibanum, Lignum Santali Albi, Radix Aristolochiae extract volatile oil, and volatile oil device is in addition collected, and is standby; Medicinal residues extract secondary with 80% alcohol heating reflux, and each 2 hours, filter and reclaim ethanol, be evaporated to relative density and be 1.25～130 thick paste, drying is pulverized, and is standby;
(c) add said extracted thing and Styrax, Borneolum Syntheticum in appropriate amount of auxiliary materials, fully mix, mixture is at 64 ℃ of heating and meltings, add standby volatile oil again, stir, mixing time is 10～30 minutes, insulation, at 64 ℃ of temperature following system, dropper bore is 1.2～2.5mm, splash in 0 ℃ the methyl-silicone oil, drip and make ball, to the greatest extent and wipe liquid coolant the drop pill drop that forms, back packing to be dried, promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2003101072973A CN100430070C (en) | 2003-12-11 | 2003-12-11 | Medication for treating coronary heart disease and angina |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2003101072973A CN100430070C (en) | 2003-12-11 | 2003-12-11 | Medication for treating coronary heart disease and angina |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1626138A CN1626138A (en) | 2005-06-15 |
| CN100430070C true CN100430070C (en) | 2008-11-05 |
Family
ID=34758106
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2003101072973A Expired - Fee Related CN100430070C (en) | 2003-12-11 | 2003-12-11 | Medication for treating coronary heart disease and angina |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100430070C (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102100807B (en) * | 2008-03-28 | 2012-10-31 | 北京亚东生物制药有限公司 | Chinese medicine composition for regulating qi, widening chest and relieving pain as well as detection method thereof |
-
2003
- 2003-12-11 CN CNB2003101072973A patent/CN100430070C/en not_active Expired - Fee Related
Non-Patent Citations (2)
| Title |
|---|
| 中华人民共和国卫生部药品标准中药成方制剂. 中华人民共和国卫生部药典委员会，146. 1997 |
| 中华人民共和国卫生部药品标准中药成方制剂. 中华人民共和国卫生部药典委员会，146. 1997 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1626138A (en) | 2005-06-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN100553615C (en) | A kind of medicine for the treatment of cardiovascular and cerebrovascular disease | |
| CN100421721C (en) | Medication for relieving cough and asthma | |
| CN100450504C (en) | Medication for treating pharyngitis | |
| CN100421684C (en) | Medication for treating coronary heart disease and angina | |
| CN100455314C (en) | Medication for treating cough | |
| CN100430070C (en) | Medication for treating coronary heart disease and angina | |
| CN1626076B (en) | Andrographolide drop pills and preparation method | |
| CN100563635C (en) | A kind of ageratum drop pill | |
| CN100553617C (en) | A kind of medicine for the treatment of obstruction of qi in the chest and cardialgia | |
| CN1872232B (en) | Composition of medication for curing cerebrovascular disease, and preparation method | |
| CN100542548C (en) | A kind of Chinese medicine preparation for the treatment of cardiovascular and cerebrovascular disease and preparation method thereof | |
| CN100421658C (en) | Medication for treating coronary heart disease and angina | |
| CN100563673C (en) | Chinese medicine preparation of treatment angina pectoris and preparation method thereof | |
| CN100502840C (en) | Medication for treating chronic rhinitis and nasal sinusitis | |
| CN100563634C (en) | A kind of Herba Sidae Rhombifoliae soup drop pill | |
| CN1872230B (en) | A medication for treating coronary heart disease and preparation method | |
| CN100553620C (en) | A kind of medicine for the treatment of the thoracic obstruction | |
| CN1626133B (en) | Medication for treating coronary heart disease | |
| CN100553618C (en) | A kind of medicine for the treatment of toothache | |
| CN100512832C (en) | Medication for treating ache | |
| CN100553652C (en) | A kind of medicine of Cure for insomnia | |
| CN100455296C (en) | Medication for treating dysmenorhea | |
| CN100512833C (en) | Medication for treating cough | |
| CN100536831C (en) | Medication for treating cardiovascular and cerebrovascular diseases | |
| CN100421702C (en) | Medication for treating obstruction of qi in the chest |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C56 | Change in the name or address of the patentee |
Owner name: TASLY PHARMACEUTICAL GROUP CO., LTD. Free format text: FORMER NAME: TIANJIN TASLY PHARMACEUTICAL CO., LTD. |
|
| CP01 | Change in the name or title of a patent holder |
Address after: 300402 Tianjin science and Technology Park of Beichen Xinyi Road Liaohe Road No. 1 white Patentee after: Tasly Pharmaceutical Group Co., Ltd. Address before: 300402 Tianjin science and Technology Park of Beichen Xinyi Road Liaohe Road No. 1 white Patentee before: Tianjin Tianshili Pharmaceutical Co., Ltd. |
|
| CP01 | Change in the name or title of a patent holder |
Address after: 300402 Tianjin science and Technology Park of Beichen Xinyi Road Liaohe Road No. 1 white Patentee after: Tasly Pharmaceutical Group Limited by Share Ltd Address before: 300402 Tianjin science and Technology Park of Beichen Xinyi Road Liaohe Road No. 1 white Patentee before: Tasly Pharmaceutical Group Co., Ltd. |
|
| CP01 | Change in the name or title of a patent holder | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20081105 Termination date: 20191211 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |