CN100421684C - Medication for treating coronary heart disease and angina - Google Patents

Medication for treating coronary heart disease and angina Download PDF

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Publication number
CN100421684C
CN100421684C CNB2003101073069A CN200310107306A CN100421684C CN 100421684 C CN100421684 C CN 100421684C CN B2003101073069 A CNB2003101073069 A CN B2003101073069A CN 200310107306 A CN200310107306 A CN 200310107306A CN 100421684 C CN100421684 C CN 100421684C
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adjuvant
salviae miltiorrhizae
standby
radix salviae
radix notoginseng
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CN1626147A (en
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李永强
陈建明
祝国光
郑永锋
朱永宏
李旭
章顺楠
刘金平
叶正良
魏峰
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Tasly Pharmaceutical Group Co Ltd
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Tianjin Tasly Pharmaceutical Co Ltd
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Abstract

The present invention provides a medicine for treating coronary artery disease and angina pectoris. The present invention overcomes the defects that the auxiliary materials of present drop pills have low pure natural degree, present common auxiliary materials chemically synthesized are not in food additive catalogues of certain countries, and the present drop pills have bad taste. The present invention is a medicinal preparation with high natural degree, high safety and low toxic side effect.

Description

A kind of treatment treating coronary heart disease and angina pectoris
Technical field
The present invention relates to field of medicaments, particularly, relating to Chinese medicine is the treatment treating coronary heart disease and angina pectoris preparation that raw material is made.
Background technology
Coronary heart disease also claims ischemic heart desease, since its sickness rate height, the mortality rate height, and the healthy of the mankind in serious harm, thereby b referred to as " the first human killers ".Angina pectoris is a coronary insufficiency, and cardiac muscle is rapid, of short duration ischemia and the caused clinical syndrome of anoxia.Angina pectoris is the coronary heart disease common sympton, be more common in more than 40 years old in, the old people, the male is more than the women.Angina pectoris usually occurs in fatigue, heavy meal, catch cold and when excited, vexed pain, squeezing pain or constriction that the right occurrence scope of metosteon is not clear, and pain is shoulder, middle finger, the third finger and little finger of toe radiation to the right.At present, it is more to be used for the treatment for the treatment of coronary heart disease and angina pectoris, though Western medicine is rapid-action, curative effect is determined, but the influence of its toxic and side effects, make the patient when curing a kind of disease, the misery that faces other be arranged, and present most of Chinese medicine preparation ubiquity curative effect instability, curative effect is low, onset is slow, consumption is many shortcoming.
The synthetic chemical substance that modern medicine is commonly used has spreaded all over each corner of human lives, chemical synthetic drug becomes the main flow of medicine, yet, appearance along with multiple difficult serious symptom miscellaneous diseases, western medical treatment presents imperfect, the human lives and the healthy reality and the up-to-date successes achieved in research have all proposed query to this situation, particularly along with the continuous appearance of chemical drugs toxic and side effects, the change of spectrum of disease and conversion of medical, make modern medicine be subjected to unprecedented challenge, and people also place hope in the application and development of traditional medicine on gradually.Advocate back to nature, pay attention to plant amedica use, hanker after traditional remedies, the trend of advocating natural drug forms, making full use of natural materials is human best selections.
At present, in the world, natural drug all has certain market, along with people increasing and the aging of population to the health requirements level of understanding, sub-health stateization, people thirst for back to nature more, the problem of utilize the high Drug therapy of pure natural degree, preventing some chemical synthetic drugs cann't be solved, so the background that exceeds its original traditional national culture has been expanded in the application of natural plant.From natural drug, seek the little and inexpensive medicine of side effect and become the target that countries in the world pharmaceutical manufacturer is chased.The European Community has carried out unified legislation to medical herbs, state medical herbs status such as Canada and Australia have legalized, U.S. government has also drafted the plant amedica management method, the compound recipe mix preparation that begins to accept natural drug is as curative, and these provide good international environment for Chinese medicine enters international medical market as curative.On the other hand, along with the quickening of global economic integration progress, particularly China becomes a full member of WTO, and Chinese Medicine market incorporates the breadth and depth of international medical big market and will further aggravate.Face the enormous impact of Asian countries's traditional medicine product such as the keen competition of powerful transnational medical group and Japan, Korea S, India, Thailand and European countries' plant amedica such as Germany, France, numerous products that China's Chinese medicine produces are owing to still can not meet the standard of international medical market and requirement and being kept outside of the door.
Expansion and human back to nature requirement along with the market global range, use the low medicine of toxic and side effects, especially pure natural medical more and more becomes people's first-selection, dropping pill formulation be a kind of have efficient, quick-acting new medicine preparations, it has overcome the shortcoming and deficiency of Chinese medicine preparation in the past, but present dropping pill formulation generally faces following problem: 1, drop pill adjuvant pure natural degree is not high: at present, drop pill substrate adjuvant mostly is synthetic, natural degree is lower, the searching of new alternative substrate adjuvant, the searching of the alternative substrate adjuvant that particularly natural degree is high and preparation technology thereof determine, it is again very difficult thing, because the required preparation condition of at present common possible natural substrates adjuvant succedaneum is very harsh, it all is to influence the key that drop pill prepares molding that adjuvant temperature and drop pill thereof drip the system condition.The too high then viscosity of adjuvant melt temperature is low, and poor plasticity is though the adjuvant melt temperature is crossed lowplastcity by force, but drop pill has shortcomings such as easily sticking ball, distortion, therefore, seek pure natural degree height, and the adjuvant that is suitable for substituting existing drop pill substrate is a very job of hardships.2, the drop pill outlet encounters problems: along with expanding economy, more and more internationalize in market, China is also just making great efforts to adapt to this trend, present Chinese medicine dripping pills preparation as health food, successful export to many countries, but also face many problems at present, because different countries is different to the approval of the selected adjuvant of Chinese medicine dropping pill formulation, especially industrial flourishing Europe, more strict to food adjuvant and medical auxiliary materials, and as the selected chemosynthesis adjuvant (as Polyethylene Glycol) of the dropping pill formulation of health food outlet not in the catalogue of some national food additive, it is very unfavorable that this moves towards the international market to the Chinese medicine dropping pill formulation, becomes the stumbling-block that Chinese medicine enters the international market, therefore, seek the new of one or more, can be particularly important, also very urgent for the substrate adjuvant that the international market is accepted.3, the shortcoming of mouthfeel and onset speed: the mouthfeel of Chinese medicine and preparation thereof is relatively poor to be the big characteristics of one, people when taking some drugs to the frightened of disagreeable taste that medicine had even be better than fear far away to disease, What is more, some patients are because can not overcome the poor taste of Chinese medicine or its preparation or abnormal smells from the patient and abandon the treatment of Chinese medicine, though can improve mouthfeel as medicine being made capsule or sugar coated tablet, reducing stimulates, but disintegration rate prolongs, be unfavorable for the rapid onset of medicine, to some disease, particularly need the disease of the rapid onset of medicine inapplicable.4, the preparation process difficulty of drop pill suitability for industrialized production: in the replacement process of dropping pill formulation adjuvant, determining of the preparation process of its suitability for industrialized production is very difficult something, as the ratio of the melt temperature of substrate adjuvant, the proportioning of dripping system temperature, adjuvant and medicine, dropper bore, condensing agent etc. all are the factors that influence drop pill, therefore, the replacement of substrate and to be suitable for suitability for industrialized production be a job consuming time, as to expend substantial contribution.
In order to change drop pill substrate adjuvant for a long time based on the situation of chemosynthesis adjuvant, it is low to solve the pure natural degree that present drop pill substrate faced, and can not satisfy more and more that people require back to nature, take low toxicity, the problem of the pure natural medical that has no side effect; Also can solve some problems that Chinese medicine preparation, particularly dropping pill formulation are run in exit procedure, strengthen the competitiveness of international market; The present invention has invented the pure Chinese medicine dripping pills preparation that a kind of toxic and side effects is low, evident in efficacy, moderate, adapt to industrialized great production by a large amount of tests and the research of preparation process.
Summary of the invention
The purpose of this invention is to provide a kind of treatment coronary heart disease, anginal medicine with the preparation of new type natural substrate adjuvant.
Another object of the present invention provides a kind of preparation method for the treatment of coronary heart disease, angina drug preparation.
The present invention is the new pharmacological action that the qi-blood relationship theory learned according to Chinese traditional medicine and modern medicine are found various institutes of Chinese materia medica, according to the principle of " symptomatic treatment in acute condition, radical treatment in chronic case ", set upright based on reinforcing, " lead to " and just must not hinder, " benefit " must not be detained, treating both the principal and secondary aspects of a disease.The medicine of producing according to this method has late result again, and finally reaches the healing purpose the existing short term effect of the treatment of coronary heart disease, and generation without any side effects.The selected substrate adjuvant of the present invention is resulting by a large amount of tests, it is little to have molecular weight, soluble in water, and molten diffusing speed is faster, pure natural degree height, toxic and side effects is lower, and can reduce the medicine irritation abnormal smells from the patient, has the oral cavity of improvement acid-base value during the buccal of oral cavity, improve the characteristics of oral cavity smell, the used substrate adjuvant of the present invention is the agent of food sedan-chair flavor, takes that mouthfeel is good, the acceptant characteristics of patient, is the direction of following substrate adjuvant development.
The selection of drug component of the present invention, consumption and adjuvant thereof also gropes to sum up to draw through the inventor in a large number, and each amounts of components all has curative effect preferably in following ranges:
Radix Salviae Miltiorrhizae 600~1800g, Radix Notoginseng 600~1800g, Lignum Dalbergiae Odoriferae oil 5~16ml, appropriate amount of auxiliary materials are made, wherein adjuvant comprises filler and plasticity substrate, said filler is selected from the natural adjuvant of following one or more plant origins: erythritol, sorbitol, fructose, D-ribonic acid-gamma lactone, arabitol, trehalose, D-ribose, low melting-point agarose, Lac, xylitol, Raffinose, glucose, malic acid, citric acid, isomalt, lactose, maltose etc., and they contain the water of crystallization chemical compound; Said plasticity substrate is selected from the natural adjuvant of following one or more plant origins: starch and derivant thereof, cellulose and derivant thereof, arabic gum, dextran, chitin, sesbania gum, carrageenan, Ficus elastica, Furcellaran, tragakanta, carrageenin, tamarind gum, pectin, xanthan gum, alginic acid and salt thereof, dextrin, cyclodextrin, agar, lactose; Described starch and derivant thereof such as pregelatinized Starch, modified starch, hydroxypropyl starch, carboxymethyl starch, described cellulose and derivant thereof such as methylcellulose, microcrystalline Cellulose, sodium carboxymethyl cellulose, hydroxypropyl emthylcellulose, cross-linking sodium carboxymethyl cellulose, hydroxyethylmethyl-cellulose, hydroxyethyl-cellulose, hydroxypropyl cellulose; Preferred drug component consumption of the present invention and adjuvant thereof be chosen as Radix Salviae Miltiorrhizae 1000~1400g, Radix Notoginseng 1000~1400g, Lignum Dalbergiae Odoriferae oil 8~12ml, appropriate amount of auxiliary materials is made, filler adjuvant wherein is selected from following one or more the natural adjuvant of plant origin: sorbitol, xylitol, lactose, maltose, and they contain the water of crystallization chemical compound; Plasticity substrate wherein is selected from following one or more the natural adjuvant of plant origin: pregelatinized Starch, carboxymethyl starch, methylcellulose, sodium carboxymethyl cellulose, hydroxypropyl emthylcellulose, arabic gum, alginic acid, dextrin, cyclodextrin, agar, lactose; Best drug component consumption of the present invention and adjuvant thereof be chosen as Radix Salviae Miltiorrhizae 1200g, Radix Notoginseng 1200g, Lignum Dalbergiae Odoriferae oil 10.5ml, appropriate amount of auxiliary materials is made, filler adjuvant wherein is selected from following one or more the natural adjuvant of plant origin: xylitol, lactose; Plasticity substrate wherein is selected from following one or more the natural adjuvant of plant origin: starch, arabic gum.
Can also contain chemosynthesis adjuvant and animal origin adjuvant in the above-mentioned dressing, wherein filler comprises phenylglycol, hexadecanol, octadecanol, sodium stearate, tristerin, tripalmitin, carbamide, polyoxyethylene monostearate, polyoxyethylene alkyl ether; Wherein plasticity substrate comprises polyvinylpyrrolidone, crospolyvinylpyrrolidone, carbomer, polyvinyl alcohol, acrylic resin, poloxamer, gelatin.
In screening to above adjuvant, we find: plant colloid such as carrageenan, the tragakanta, pectin, agar, arabic gum, Ficus elastica, tamarind gum, locust bean gum, Pseudobulbus Bletillae (Rhizoma Bletillae) glue, guar gum, Konjac glucomannan, it is big that plant colloids such as POLY-karaya have viscosity, mobile poor, characteristics such as do not solidify after the condensation, and arabic gum has high dense low sticking character, can be mixed with the aqueous solution of 50% concentration and still have flowability, this is one of not available characteristics of other hydrophilic colloid, arabic gum has at high temperature, under the low concentration, can ooze, but not condensation, at low temperature, under the high concentration, be difficult for oozing, but characteristics such as energy condensation.Polysaccharide such as polysaccharide such as starch and derivant thereof (as gelling starch, carboxymethyl starch etc.), cellulose derivative (as methylcellulose, sodium carboxymethyl cellulose, hydroxypropyl emthylcellulose etc.), alginic acid, dextrin, cyclodextrin, lactose, in screening, find alginic acid have viscosity big, be the fruit jelly sample, dextrin has the colloid sample, characteristics such as lactose coagulability difference; And starch and derivant thereof are materials commonly used in the medical science adjuvant, thus in polysaccharide preferred starch and derivant thereof.Polyhydric alcohol such as sorbitol (88~102 ℃), xylitol (88~94.5 ℃), lactose (70~80 ℃), mannitol (166~169 ℃), maltose alcohol (135~140 ℃), isomalt polyhydric alcohol such as (98~103 ℃) screen, and find that it has following characteristics as drop pill substrate: sorbitol, lactose, isomalt are mobile poor; Mannitol, maltose alcohol fusing point are too high; The xylitol coagulability is poor slightly.After Preliminary screening, preferred xylitol, lactose, sorbitol in the selection of polyhydric alcohol, the best is an xylitol.Xylitol has following characteristics as drop pill substrate: in the time of 91 ℃, molten condition has appearred in xylitol, but not fusion fully, cooling rapidly, it separates out crystallization very soon, xylitol mixes the back good fluidity with extractum at certain proportion, can drip and can condensation, but be condensed into Powdered thing, loosely organized, the toughness extreme difference, that pinches is promptly broken.Organic acid and salt, alkali such as citric acid (100 ℃), sorbic acid (133 ℃), succinic acid (181~189 ℃), sodium acetate organic acid such as (58 ℃) and salt, alkali, its as drop pill substrate have fusing point too high, with Chinese medical concrete can't mixing etc. shortcoming.
Because of above single adjuvant existing shortcoming in as the drop pill preparation process, particularly we by above-mentioned Preliminary screening after, determine two kinds of adjuvants are used and screen: mainly be that above various adjuvants are carried out combined sorting, final determine following several: the plant colloid cooperates with the plant colloid, the cooperating of polyhydric alcohol and polyhydric alcohol, polyhydric alcohol and plant colloidally cooperate, the cooperating of the cooperating of xylitol and arabic gum, lactose and arabic gum, based on the composite auxiliary material of xylitol.Find preferred the cooperation to be xylitol, lactose and the compound use of other adjuvant, this kind combination has following characteristics: make up with mannitol: can drip not condensation; Make up with sorbic acid: both do not dissolve each other; Make up with lactose: can drip the energy condensation, but frangible; Make up with pomelo-pectin, tragakanta, sodium alginate: viscosity is big, can't drip; Make up with arabic gum: can drip, coagulability is poor slightly; Make up with dextrin: can drip, coagulability is poor slightly; Make up with starch: can drip, coagulability is also better.Determine that at last best of breed is that xylitol cooperates with arabic gum with starch, xylitol with starch, lactose.
At xylitol and starch, lactose and starch, in the research of xylitol and arabic gum combination, xylitol and starch Application of composite being prepared some required in the process of drop pill factors investigated, mainly is to the xylitol type, condensed fluid, condensate temperature influences the drop pill mouldability, xylitol and starch proportion influence mouldability, temperature is to the influence of drop pill mouldability, the extractum amount influences the drop pill mouldability, mixing time influences the drop pill mouldability, the dropper bore is to the influence of drop pill particle diameter, the formulation optimization of drop pill, the Preliminary Determination of drop pill, dissolve scattered time limit is investigated.Find that the solid xylitol has three types of powder, granular and crystallinity, and the easiest fusion of powder xylitol, again can fine dissolving be dispersed in the mixed liquor that starch, extractum forms, good fluidity, drippage is easy, and granular and crystalline xyhose alcohol is difficult for fusion, solubility property is also slightly poor, the mix flow that they and starch, extractum form is relatively poor, viscosity is very big, almost cannot drip, and therefore drips first-selected powder xylitol in the system process at drop pill.
At ratio of adjuvant molding is found in the sex research, in the combination of xylitol and starch, lactose and starch, xylitol and arabic gum, low melting point substrate adjuvant is 1: 0~1: 1.5 with the ratio of the weight of plasticity substrate adjuvant, be preferably 1: 0.1~1: 0.9, the best is 1: 0.1~1: 0.5.Low melting point substrate adjuvant of being formed within this scope and plasticity substrate adjuvant, the drug matrices fused solution all can ooze, and can condensation.Specific to each combination, xylitol is preferably 1: 0.2 with the ratio of the weight of starch~1: 0.3, and lactose is preferably 1: 0.2 with the ratio of the weight of starch~1: 0.3, and the ratio of the weight of xylitol and arabic gum is preferably 1: 0.2~and 1: 0.4.Find that in the research of temperature temperature is big especially to the influence of drop pill mouldability to the influence of drop pill mouldability, when temperature is too low, owing to the too big effect that oozes that influences drop pill of viscosity of substrate, when temperature is too high, not condensation of drop pill.Find that mixing time can have influence on the mouldability of drop pill in mixing time in to the sex research of drop pill molding, mixing time is too short, and mobile poor, influence oozes, and mixing time is oversize, influences the condensation of drop pill.Dripping under the system temperature, mixing time in 1~120 minute all can, suitable mixing time was at 10~30 minutes.Consider that mixing time can not be too short in the suitability for industrialized production, adopt the method that low temperature stirs for a long time, high temperature drips system.Find that in the research of dropper bore to the influence of drop pill particle diameter the dropper bore influences the size of drop pill and the flowability of fusion substrate, the system effect is dripped in influence.Drop pill diminishes and diminishes along with bore, but after 1.4 millimeters, along with the bore change of size that diminishes is not obvious, but the matrix flow reduction, system is dripped in influence.
So in the preparation method of preparation, medicine mixes mixing time with the substrate adjuvant be 10~30 minutes; The mixed heating and melting temperature of medicine and substrate adjuvant is 45~115 ℃, dripping the system temperature is 45~95 ℃, and liquid coolant is liquid paraffin, methyl-silicone oil or vegetable oil (Oleum Glycines, Semen Ricini wet goods), and the temperature of liquid coolant is-20~25 ℃, dropper mouth internal diameter is 1.0~4.0 millimeters; Preferred heating and melting temperature is 60~85 ℃, and dripping a system temperature is 60~85 ℃, and condensing agent is liquid paraffin, methyl-silicone oil, and the condensing agent temperature is 0~18 ℃, and the dropper bore is 1.1~3.5 millimeters, and the difference of dropper mouth external diameter and internal diameter is less for well; Best heating and melting temperature is that to make temperature be that 64 ℃, dropper bore are that 1.2~2.5 millimeters, condensing agent are 0 ℃ methyl-silicone oil to 64 ℃, droplet.
The substrate adjuvant of the best of the present invention is xylitol and starch, and xylitol is 1: 0.2~1: 0.3 with the ratio of the weight of starch; Or be lactose and starch, lactose is 1: 0.2~1: 0.3 with the ratio of the weight of starch; Or be xylitol and arabic gum, the ratio of the weight of xylitol and arabic gum is 1: 0.2~1: 0.4.
Xylitol is a kind of natural plant sweetening agent, approve through World Health Organization (WHO), xylitol is a kind of safest sweeting agent, countries in the world are extensive use of in fields such as food and oral-cavity articles, xylitol enters the help that need not insulin in the cell, when sugar utilizes obstacle, can not cause blood sugar increasing yet, can improve diabetics symptom, have the ketoplastic effect of powerful inhibition, can promote the generation of liver glycogen, directly infiltrate the Developmental and Metabolic Disorder that tissue is participated in metabolism, can be corrected protein, fat and steroid; Xylose is the internal metabolism intermediate product, and body has higher toleration to it.Clinical practice proves: the highest oral dosis tolerata can reach 220g every day, and intravenous drip every day can reach 100g.The oral 25700mg/Kg of median lethal dose(LD 50) (LD50) mice, quiet notes 6400mg/Kg, the quiet notes of rat 6200mg/Kg.
Medicine mesostroma adjuvant of the present invention and amount of drug are than can being the scope that allows on the galenic pharmacy, medicine described here can be that crude drug also can be the effective ingredient extract, in order to adapt to industrialized great production, the ratio range of mesostroma adjuvant of the present invention and medicine refers to the weight proportion of adjuvant and extract drugs extractum, and the substrate adjuvant is 1: 0.1~1: 1 with the ratio of the weight of drug extract; Preferred substrate adjuvant is 1: 0.1~1: 0.6 with the ratio of the weight of extract drugs extractum; Best substrate adjuvant is 1: 0.2~1: 0.4 with the ratio of the extraction extractum weight of medicine.
Medicine of the present invention can adopt the preparation of Chinese medicine preparation conventional method.The preparation of effective ingredient of the present invention can be adopted following method: water extraction, decoction and alcohol sedimentation technique, extraction, infusion process, percolation, reflux extraction, continuous backflow extraction method, macroreticular resin absorbing method preparation.For example, these crude drug pulverize mix homogeneously can be made powder takes after mixing it with water; Also can be with these medicines decocting together, the condensed water decocting liquid is made oral liquid then; But, preferably adopt following technology to extract, but this can not limit protection scope of the present invention to raw material in order to make each crude drug of this medicine better bring into play drug effect.
The preparation method of medicine of the present invention is as follows:
(a): get Radix Salviae Miltiorrhizae 600~1800g, Radix Notoginseng 600~1800g, Lignum Dalbergiae Odoriferae oil 5~16ml is standby;
(b): above three flavors, Radix Salviae Miltiorrhizae ethanol extraction secondary, each 30~180 minutes, filter, filtrate merges, and reclaims ethanol and continues to be condensed into clear paste, and is standby; Radix Notoginseng powder is broken into coarse powder, 50~95% alcohol reflux secondaries, and each 0.5~4 hour, merge extractive liquid, filtered, filtrate recycling ethanol, and continue to be condensed into clear paste, and adding a spot of kieselguhr, concentrating under reduced pressure becomes clear paste, and is standby;
(c): in appropriate amount of auxiliary materials, add above-mentioned Radix Salviae Miltiorrhizae and Radix Notoginseng extractum, Lignum Dalbergiae Odoriferae oil, fully mix, mixture stirs at 45~115 ℃ of heating and meltings, mixing time is 1~120 minute, insulation is 1.0~4.0 millimeters at 45~95 ℃ of temperature following system, dropper bore, splashes in-20~25 ℃ liquid paraffin, methyl-silicone oil or the vegetable oil, liquid coolant is use up and wiped to the drop pill drop that forms, back packing to be dried is made the 1000g drop pill, promptly.
Preferred process for preparing medicine of the present invention comprises the following steps:
(a): get Radix Salviae Miltiorrhizae 1000~1400g, Radix Notoginseng 1000~1400g, Lignum Dalbergiae Odoriferae oil 8~12ml is standby;
(b): above three flavors, Radix Salviae Miltiorrhizae ethanol extraction secondary, each 60~90 minutes, filter, filtrate merges, and recovery ethanol and continuing is concentrated at 60 ℃, the clear paste of relative density 1.05~1.35, and is standby; Radix Notoginseng powder is broken into coarse powder, 60~80% alcohol reflux secondaries, each 2~3 hours, merge extractive liquid, filters filtrate recycling ethanol, and continue to be concentrated at 60 ℃, the clear paste of relative density 1.05~1.35, add a spot of kieselguhr, be evaporated at 60 ℃, the clear paste of relative density 1.05~1.35, standby;
(c): in appropriate amount of auxiliary materials, add above-mentioned Radix Salviae Miltiorrhizae and Radix Notoginseng extractum, Lignum Dalbergiae Odoriferae oil, fully mix, mixture stirs at 60~85 ℃ of heating and meltings, mixing time is 10~30 minutes, insulation is 1.1~3.5 millimeters at 60~85 ℃ of temperature following system, dropper bore, splashes in 0~18 ℃ the liquid paraffin, methyl-silicone oil, liquid coolant is use up and wiped to the drop pill drop that forms, back packing to be dried is made the 1000g drop pill, promptly.
Best process for preparing medicine of the present invention comprises the following steps:
(a): get Radix Salviae Miltiorrhizae 1200g, Radix Notoginseng 1200g, Lignum Dalbergiae Odoriferae oil 10.5ml is standby;
(b): above three flavors, Radix Salviae Miltiorrhizae ethanol extraction secondary, each 70 minutes, filter, filtrate merges, and recovery ethanol and continuing is concentrated at 60 ℃, the clear paste of relative density 1.20~1.25, and is standby; Radix Notoginseng powder is broken into coarse powder, 70% alcohol reflux secondary, each 1.5 hours, merge extractive liquid, filters filtrate recycling ethanol, and continue to be concentrated into the clear paste of relative density 1.20~1.25 (60 ℃ of surveys), add a spot of kieselguhr, be evaporated under 80 ℃ of conditions at 60 ℃, the clear paste of relative density 1.20~1.25, standby;
(c): in appropriate amount of auxiliary materials, add above-mentioned Radix Salviae Miltiorrhizae and Radix Notoginseng extractum, Lignum Dalbergiae Odoriferae oil, fully mix, insulation stirs, mixing time is 10~30 minutes, mixture is 1.2~2.5 millimeters at 64 ℃ of heating and meltings at 64 ℃ of temperature following system, dropper bore, splashes in 0 ℃ the methyl-silicone oil, liquid coolant is use up and wiped to the drop pill drop that forms, back packing to be dried is made the 1000g drop pill, promptly.
The best preparation method of medicine of the present invention is:
(a): get Radix Salviae Miltiorrhizae 1200g, Radix Notoginseng 1200g, Lignum Dalbergiae Odoriferae oil 10.5ml is standby;
(b): above three flavors, Radix Salviae Miltiorrhizae ethanol extraction secondary, each 70 minutes, filter, filtrate merges, and recovery ethanol and continuing is concentrated at 60 ℃, the clear paste of relative density 1.20~1.25, and is standby; Radix Notoginseng powder is broken into coarse powder, 70% alcohol reflux secondary, each 1.5 hours, merge extractive liquid, filters filtrate recycling ethanol, and continue to be concentrated into the clear paste of relative density 1.20~1.25 (60 ℃ of surveys), add a spot of kieselguhr, be evaporated under 80 ℃ of conditions at 60 ℃, the clear paste of relative density 1.20~1.25, standby;
(c): to ratio an amount of, weight is 1: 0.2~1: 0.3 xylitol and starch mixture; Or the ratio of weight is 1: 0.2~1: 0.3 lactose and starch mixture; Or the ratio of weight is to add above-mentioned Radix Salviae Miltiorrhizae and Radix Notoginseng extractum, Lignum Dalbergiae Odoriferae oil in 1: 0.2~1: 0.4 xylitol and the arabic gum mixture, fully mix, move in the reservoir, mixture stirs at 64 ℃ of heating and meltings, mixing time is 10~30 minutes, insulation is 1.2~2.5 millimeters at 64 ℃ of temperature following system, dropper bore and splashes in 0 ℃ the methyl-silicone oil, and liquid coolant is use up and wiped to the drop pill drop of formation, back packing to be dried is made 1000g promptly.
More than form when producing and to increase or to reduce according to corresponding ratio, as large-scale production can be unit with kilogram or with the ton, small-scale production can be unit with the gram also, and weight can increase or reduce, but the crude drug material weight proportion constant rate between each composition.
More than each single medicinal material, especially adjuvant drug, messenger drug or adjuvant drug and messenger drug in forming, can be replaced by suitable Chinese medicine individually or simultaneously with the identical property of medicine, effect, it is constant to replace back Chinese medicine preparation and drug effect thereof.
Medicine of the present invention can be determined usage and dosage according to patient's situation in use, but every day 1-3 time, and every day, each crude drug consumption was as the criterion with the state-promulgated pharmacopoeia dosage, was no more than the pharmacopeia ormal weight.
The drop pill that the present invention is prepared, conventional drop pill advantage is simple as preparing except having, steady quality, can make liquid medicine solidification, convenient drug administration, efficient, quick-acting, its biggest advantage is:
1, the selected adjuvant pure natural of the present invention degree height: the substrate adjuvant that employed substrate adjuvant derives from natural plants or originates based on natural plants among the present invention, selected substrate adjuvant is xylitol and starch or lactose and starch or xylitol and arabic gum, this substrate adjuvant has pure natural degree height, toxic and side effects is low, mouthfeel is good, dissolve scattered time limit is short, rapid-action, it is a kind of new medium adjuvant, can be used for substituting present chemosynthesis adjuvant, the drop pill made from this kind adjuvant, it is low to solve the pure natural degree that present drop pill substrate faced, and more and more can not satisfy people and require back to nature, take low toxicity, the problem of the pure natural medical that has no side effect.
2, some problems in the outlet of solution Chinese medicine: medicine of the present invention also can solve Chinese medicine preparation, some problems of in exit procedure, being run into of dropping pill formulation particularly, solve because different countries, especially the European countries of industry prosperity are to the difference identification of the selected adjuvant of Chinese medicine dropping pill formulation, overcome as the selected adjuvant Polyethylene Glycol of the dropping pill formulation of the health food outlet defective in some national food additive catalogue not, improve the Chinese medicine dripping pills preparation and move towards the international market, strengthen the competitiveness of international market.
3, solve the relatively poor problem of drop pill taste and further improve drug effect speed (dissolve scattered time limit): the medicinal dropping ball made from this kind substrate adjuvant of the present invention, can improve Chinese medicine preparation, the particularly present not good shortcoming of dropping pill formulation taste, improve mouthfeel, more easy for patients to accept, and the drop pill that adopts the selected adjuvant of medicine of the present invention to make has shorter dissolve scattered time limit, making drug effect faster, is the medicine that coronary heart disease, angina pectoris, myocardial ischemia are treated in a kind of onset faster.
4, higher safety and solve some problems in the drop pill storage process: the selected substrate of the present invention is not only additive, nutrient commonly used in the food industry, and can do medicinal, but do not see that it uses as the drug matrices adjuvant, therefore, with regard to substrate, be perfectly safe, have no side effect, a large amount of evidences, the drop pill made from this adjuvant can reduce effective ingredient separating out in storage process, the sticking ball of drop pill, easy shortcomings such as moisture absorption deliquescing, but the big production of suitability for industrialized.
The present invention is under instruction of Chinese Medicine theory, preparation technology's test that process is a large amount of and pharmacology, the resulting preparation of pharmacodynamics test.The present invention is evident in efficacy, has activating blood circulation to dissipate blood stasis, and the effect of regulating QI to relieve pain is used for the treatment of particularly symptom such as uncomfortable in chest, the chest pain due to the qi stagnation blood stasis type coronary heart disease, shortness of breath and palpitation of angina pectoris clinically.The present invention is a kind of economy, material benefit, the definite treatment treating coronary heart disease and angina pectoris of curative effect.
In order to understand the present invention better, dissolve scattered time limit, the weight differential comparative test with GUANXIN DANSHEN DIWAN illustrates advantage of the present invention below.
Test example 1: dissolve scattered time limit, weight differential contrast experiment's example
In vitro tests
The present invention be that the GUANXIN DANSHEN DIWAN that adjuvant is made compares with the Polyethylene Glycol, by measuring index such as dissolve scattered time limit, investigate its good releasing effect; Whether by weight differential, it is ripe to investigate its preparation technology, whether is fit to suitability for industrialized production.
1. test medication: the new substrate GUANXIN DANSHEN DIWAN of the present invention (newly) is provided by the Jinshili Medicine Research ﹠. Development Co., Ltd., Tianjin; With the Polyethylene Glycol is the GUANXIN DANSHEN DIWAN (old) that adjuvant is made, and Zhongfa Industry Group Yerui Medicine Industry Co., Ltd. produces.
2. method and result:
Dissolve scattered time limit: by " method is measured under this item of Chinese pharmacopoeia; The ball method of double differences is different: by " method is measured under this item of Chinese pharmacopoeia.Result of the test sees Table 1.
Three batches of GUANXIN DANSHEN DIWAN made from the new medium adjuvant of table 1 (newly) with the polyethylene glycol 6000 be GUANXIN DANSHEN DIWAN (old) dissolve scattered time limit made of adjuvant, weight differential relatively
Figure C20031010730600131
Result of the test shows, the dissolve scattered time limit of new substrate GUANXIN DANSHEN DIWAN is that the GUANXIN DANSHEN DIWAN made of adjuvant is few with the Polyethylene Glycol, and the ball method of double differences of the GUANXIN DANSHEN DIWAN that new and old substrate is made is different all to be controlled in the pharmacopeia prescribed limit.Presentation of results, the molten diffusing speed of the GUANXIN DANSHEN DIWAN made from novel adjuvant is faster, is more conducive to medicine and plays a role in the shortest time; The ball method of double differences is different all to be controlled in the pharmacopeia prescribed limit, and the difference not statistically significant illustrates the alternative present chemosynthesis adjuvant of this natural substrates adjuvant, but suitability for industrialized production.
Test example 2: the present invention with the polyethylene glycol 6000 be the sticking ball comparative observation of GUANXIN DANSHEN DIWAN soft durometer, drop pill that adjuvant is made
1. reagent: the new substrate GUANXIN DANSHEN DIWAN of the present invention (newly) is the GUANXIN DANSHEN DIWAN (old) that adjuvant is made with the Polyethylene Glycol.
2. method and result: three batches of the things of getting it filled are loaded in the porcelain vase respectively, and use the bottle stopper good seal.Putting it into the bottom has in the exsiccator of saturated Nacl (humidity 75%) solution, exsiccator is put into 40 ℃ of drying baker of constant temperature again, and timing sampling is observed situations such as drop pill soft durometer, the sticking ball of drop pill, the results are shown in Table 2.1, table 2.2.
Three batches in table 2.1 is that the GUANXIN DANSHEN DIWAN reserved sample observing that adjuvant is made compares with the polyethylene glycol 6000
Figure C20031010730600141
Table 2.2: three batches of GUANXIN DANSHEN DIWAN made from the new medium adjuvant (newly) with the polyethylene glycol 6000 be GUANXIN DANSHEN DIWAN (old) character observation made of adjuvant relatively
Figure C20031010730600151
Test data shows, the soft durometer of new substrate GUANXIN DANSHEN DIWAN changes and be that the GUANXIN DANSHEN DIWAN made of adjuvant is similar, strong slightly with the Polyethylene Glycol; The sticking ball variation of the drop pill of new substrate GUANXIN DANSHEN DIWAN, firmness change and be that the GUANXIN DANSHEN DIWAN made of adjuvant is similar with the Polyethylene Glycol.Presentation of results, the sticking ball of the GUANXIN DANSHEN DIWAN that new, old substrate adjuvant is made changes, firmness change is similar, and the alternative present chemosynthesis adjuvant of this natural substrates adjuvant is described, but suitability for industrialized production.
The specific embodiment
Embodiment 1
(a): get Radix Salviae Miltiorrhizae 1200g, Radix Notoginseng 1200g, Lignum Dalbergiae Odoriferae oil 10.5ml, xylitol 633g, starch 127g is standby;
(b): above three flavors, Radix Salviae Miltiorrhizae ethanol extraction secondary, each 70 minutes, filter, filtrate merges, and recovery ethanol also continues to be concentrated into the clear paste of relative density 1.20~1.25 (60 ℃ of surveys), and is standby; Radix Notoginseng powder is broken into coarse powder, 70% alcohol reflux secondary, each 1.5 hours, merge extractive liquid, filters filtrate recycling ethanol, and continue to be concentrated into the clear paste of relative density 1.20~1.25 (60 ℃ of surveys), add a spot of kieselguhr, (80 ℃) are evaporated to the clear paste of relative density 1.20~1.25 (60 ℃ of surveys), and are standby;
(c): in xylitol and starch mixture, add above-mentioned Radix Salviae Miltiorrhizae and Radix Notoginseng extractum, Lignum Dalbergiae Odoriferae oil, fully mix, mixture stirs at 64 ℃ of heating and meltings, and mixing time is 10~30 minutes, insulation, at 64 ℃ of temperature following system, dropper bore is 1.2~2.5 millimeters, splashes in 0 ℃ the methyl-silicone oil, with the drop pill drop that forms to the greatest extent and wipe liquid coolant, back packing to be dried is made 1000g promptly.
Embodiment 2
(a): get Radix Salviae Miltiorrhizae 1200g, Radix Notoginseng 1200g, Lignum Dalbergiae Odoriferae oil 10.5ml, xylitol 538g, starch 162g is standby;
(b): above three flavors, Radix Salviae Miltiorrhizae ethanol extraction secondary, each 70 minutes, filter, filtrate merges, and recovery ethanol also continues to be concentrated into the clear paste of relative density 1.20~1.25 (60 ℃ of surveys), and is standby; Radix Notoginseng powder is broken into coarse powder, 70% alcohol reflux secondary, each 1.5 hours, merge extractive liquid, filters filtrate recycling ethanol, and continue to be concentrated into the clear paste of relative density 1.20~1.25 (60 ℃ of surveys), add a spot of kieselguhr, (80 ℃) are evaporated to the clear paste of relative density 1.20~1.25 (60 ℃ of surveys), and are standby;
(c): in xylitol and starch mixture, add above-mentioned Radix Salviae Miltiorrhizae and Radix Notoginseng extractum, Lignum Dalbergiae Odoriferae oil, fully mix, mixture stirs at 64 ℃ of heating and meltings, and mixing time is 10~30 minutes, insulation, at 64 ℃ of temperature following system, dropper bore is 1.2~2.5 millimeters, splashes in 0 ℃ the methyl-silicone oil, with the drop pill drop that forms to the greatest extent and wipe liquid coolant, back packing to be dried is made 1000g promptly.
Embodiment 3
(a): get Radix Salviae Miltiorrhizae 1200g, Radix Notoginseng 1200g, Lignum Dalbergiae Odoriferae oil 10.5ml, xylitol 571g, arabic gum 229g is standby;
(b): above three flavors, Radix Salviae Miltiorrhizae ethanol extraction secondary, each 70 minutes, filter, filtrate merges, and recovery ethanol also continues to be concentrated into the clear paste of relative density 1.20~1.25 (60 ℃ of surveys), and is standby; Radix Notoginseng powder is broken into coarse powder, 70% alcohol reflux secondary, each 1.5 hours, merge extractive liquid, filters filtrate recycling ethanol, and continue to be concentrated into the clear paste of relative density 1.20~1.25 (60 ℃ of surveys), add a spot of kieselguhr, (80 ℃) are evaporated to the clear paste of relative density 1.20~1.25 (60 ℃ of surveys), and are standby;
(c): in xylitol and arabic gum mixture, add above-mentioned Radix Salviae Miltiorrhizae and Radix Notoginseng extractum, Lignum Dalbergiae Odoriferae oil, fully mix, mixture stirs at 64 ℃ of heating and meltings, and mixing time is 10~30 minutes, insulation, at 64 ℃ of temperature following system, dropper bore is 1.2~2.5 millimeters, splashes in 0 ℃ the methyl-silicone oil, with the drop pill drop that forms to the greatest extent and wipe liquid coolant, back packing to be dried is made 1000g promptly.
Embodiment 4
(a): get Radix Salviae Miltiorrhizae 1800g, Radix Notoginseng 1800g, Lignum Dalbergiae Odoriferae oil 10.5ml, xylitol 592g, starch 148g is standby;
(b): above three flavors, Radix Salviae Miltiorrhizae ethanol extraction secondary, each 70 minutes, filter, filtrate merges, and recovery ethanol also continues to be concentrated into the clear paste of relative density 1.05 (60 ℃ of surveys), and is standby; Radix Notoginseng powder is broken into coarse powder, 80% alcohol reflux secondary, each 2 hours, merge extractive liquid, filters filtrate recycling ethanol, and continue to be concentrated into the clear paste of relative density 1.10~1.20 (60 ℃ of surveys), add a spot of kieselguhr, (80 ℃) are evaporated to the clear paste of relative density 1.10~1.20 (60 ℃ of surveys), and are standby;
(c): in xylitol and starch mixture, add above-mentioned Radix Salviae Miltiorrhizae and Radix Notoginseng extractum, Lignum Dalbergiae Odoriferae oil, fully mix, mixture stirs at 85 ℃ of heating and meltings, and mixing time is 10~30 minutes, insulation, at 60 ℃ of temperature following system, dropper bore is 1.1~1.4 millimeters, splashes in 5~8 ℃ the liquid paraffin, with the drop pill drop that forms to the greatest extent and wipe liquid coolant, back packing to be dried is made 1000g promptly.
Embodiment 5
(a): get Radix Salviae Miltiorrhizae 600g, Radix Notoginseng 600g, Lignum Dalbergiae Odoriferae oil 16ml, xylitol 736g, starch 184g is standby;
(b): above three flavors, Radix Salviae Miltiorrhizae ethanol extraction secondary, each 90 minutes, filter, filtrate merges, and reclaims ethanol and continues to be condensed into clear paste, and is standby; Radix Notoginseng powder is broken into coarse powder, 80~95% alcohol reflux secondaries, and each 3 hours, merge extractive liquid, filtered, filtrate recycling ethanol, and continue to be condensed into clear paste, and adding a spot of kieselguhr, concentrating under reduced pressure becomes clear paste, and is standby;
(c): in xylitol and starch mixture, add above-mentioned Radix Salviae Miltiorrhizae and Radix Notoginseng extractum, Lignum Dalbergiae Odoriferae oil, fully mix, mixture stirs at 60~85 ℃ of heating and meltings, and mixing time is 10~30 minutes, insulation, at 60~85 ℃ of temperature following system, dropper bore is 1.1~3.5 millimeters, splashes in 8~12 ℃ the liquid paraffin, with the drop pill drop that forms to the greatest extent and wipe liquid coolant, back packing to be dried is made 1000g promptly.
Embodiment 6
(a): get Radix Salviae Miltiorrhizae 1800g, Radix Notoginseng 600g, Lignum Dalbergiae Odoriferae oil 5ml, xylitol 142g, starch 58g is standby;
(b): above three flavors, Radix Salviae Miltiorrhizae ethanol extraction secondary, each 70 minutes, filter, filtrate merges, and recovery ethanol also continues to be concentrated into the clear paste of relative density 1.20~1.25 (60 ℃ of surveys), and is standby; Radix Notoginseng powder is broken into coarse powder, 70% alcohol reflux secondary, each 1.5 hours, merge extractive liquid, filters filtrate recycling ethanol, and continue to be concentrated into the clear paste of relative density 1.20~1.25 (60 ℃ of surveys), add a spot of kieselguhr, (80 ℃) are evaporated to the clear paste of relative density 1.20~1.25 (60 ℃ of surveys), and are standby;
(c): in xylitol and starch mixture, add above-mentioned Radix Salviae Miltiorrhizae and Radix Notoginseng extractum, Lignum Dalbergiae Odoriferae oil, fully mix, mixture stirs at 60~70 ℃ of heating and meltings, and mixing time is 120 minutes, insulation, at 80 ℃ of temperature following system, dropper bore is 1.1~2.5 millimeters, splashes in 12~18 ℃ the liquid paraffin, with the drop pill drop that forms to the greatest extent and wipe liquid coolant, back packing to be dried is made 1000g promptly.
Embodiment 7
(a): get Radix Salviae Miltiorrhizae 1400g, Radix Notoginseng 1000g, Lignum Dalbergiae Odoriferae oil 12ml, lactose 640g, starch 122g is standby;
(b): above three flavors, Radix Salviae Miltiorrhizae ethanol extraction secondary, each 60~90 minutes, filter, filtrate merges, and recovery ethanol and continuing is concentrated at 60 ℃, the clear paste of relative density 1.05~1.35, and is standby; Radix Notoginseng powder is broken into coarse powder, 60~80% alcohol reflux secondaries, each 2~3 hours, merge extractive liquid, filters filtrate recycling ethanol, and continue to be concentrated at 60 ℃, the clear paste of relative density 1.05~1.35, add a spot of kieselguhr, be evaporated at 60 ℃, the clear paste of relative density 1.05~1.35, standby;
(c): in lactose and starch mixture, add above-mentioned Radix Salviae Miltiorrhizae and Radix Notoginseng extractum, Lignum Dalbergiae Odoriferae oil, fully mix, mixture stirs at 70~85 ℃ of heating and meltings, mixing time is 5 minutes, insulation is 1.2~3.0 millimeters at 60 ℃ of temperature following system, dropper bore, splashes in 8~12 ℃ the methyl-silicone oil, liquid coolant is use up and wiped to the drop pill drop that forms, pour in the dish that is lined with absorbent paper, back packing to be dried is made 1000g promptly.
Embodiment 8
(a): get Radix Salviae Miltiorrhizae 1000g, Radix Notoginseng 1400g, Lignum Dalbergiae Odoriferae oil 8ml, lactose 608g, xanthan gum 152g is standby;
(b): above three flavors, Radix Salviae Miltiorrhizae ethanol extraction secondary, each 60~90 minutes, filter, filtrate merges, and recovery ethanol and continuing is concentrated at 60 ℃, the clear paste of relative density 1.05~1.35, and is standby; Radix Notoginseng powder is broken into coarse powder, 60~80% alcohol reflux secondaries, each 2~3 hours, merge extractive liquid, filters filtrate recycling ethanol, and continue to be concentrated at 60 ℃, the clear paste of relative density 1.05~1.35, add a spot of kieselguhr, be evaporated at 60 ℃, the clear paste of relative density 1.05~1.35, standby;
(c): in lactose, xanthan gum mixtures, add above-mentioned Radix Salviae Miltiorrhizae and Radix Notoginseng extractum, Lignum Dalbergiae Odoriferae oil, fully mix, mixture stirs at 85 ℃ of heating and meltings, mixing time is 12 minutes, insulation is 1.2~2.5 millimeters at 64 ℃ of temperature following system, dropper bore, splashes in-15 ℃ the methyl-silicone oil, liquid coolant is use up and wiped to the drop pill drop that forms, pour in the dish that is lined with absorbent paper, back packing to be dried is made 1000g promptly.
Embodiment 9
(a): get Radix Salviae Miltiorrhizae 900g, Radix Notoginseng 1000g, Lignum Dalbergiae Odoriferae oil 6.5ml, xylitol 560g, starch 140g is standby;
(b): above three flavors, Radix Salviae Miltiorrhizae ethanol extraction secondary, each 50 minutes, filter, filtrate merges, and recovery ethanol also continues to be concentrated into the clear paste of relative density 1.10~1.15 (60 ℃ of surveys), and is standby; Radix Notoginseng powder is broken into coarse powder, 80% alcohol reflux secondary, each 1.5 hours, merge extractive liquid, filters filtrate recycling ethanol, and continue to be concentrated into the clear paste of relative density 110~1.15 (60 ℃ of surveys), add a spot of kieselguhr, (80 ℃) are evaporated to the clear paste of relative density 1.20~1.25 (60 ℃ of surveys), and are standby;
(c): in xylitol and starch mixture, add above-mentioned Radix Salviae Miltiorrhizae and Radix Notoginseng extractum, Lignum Dalbergiae Odoriferae oil, fully mix, mixture stirs at 65 ℃ of heating and meltings, mixing time is 20 minutes, insulation is 1.21~2.5 millimeters at 60 ℃ of temperature following system, dropper bore, splashes in 0 ℃ the methyl-silicone oil, liquid coolant is use up and wiped to the drop pill drop that forms, pour in the dish that is lined with absorbent paper, back packing to be dried is made 1000g promptly.
Embodiment 10
(a): get Radix Salviae Miltiorrhizae 600g, Radix Notoginseng 600g, Lignum Dalbergiae Odoriferae oil 5.5ml, xylitol 727g, starch 72g is standby;
(b): above three flavors, Radix Salviae Miltiorrhizae ethanol extraction secondary, each 60 minutes, filter, filtrate merges, and recovery ethanol also continues to be concentrated into the clear paste of relative density 1.20~1.25 (70 ℃ of surveys), and is standby; Radix Notoginseng powder is broken into coarse powder, 70% alcohol reflux secondary, each 2.5 hours, merge extractive liquid, filters filtrate recycling ethanol, and continue to be concentrated into the clear paste of relative density 1.20~1.25 (60 ℃ of surveys), add a spot of kieselguhr, (60 ℃) are evaporated to the clear paste of relative density 1.20~1.25 (60 ℃ of surveys), and are standby;
(c): in xylitol and starch mixture, add above-mentioned Radix Salviae Miltiorrhizae and Radix Notoginseng extractum, Lignum Dalbergiae Odoriferae oil, fully mix, mixture stirs at 115 ℃ of heating and meltings, mixing time is 5 minutes, insulation is 1.3~3.5 millimeters at 45 ℃ of temperature following system, dropper bore, splashes in 8~12 ℃ the vegetable oil, liquid coolant is use up and wiped to the drop pill drop that forms, pour in the dish that is lined with absorbent paper, back packing to be dried is made 1000g promptly.
Embodiment 11
(a): get Radix Salviae Miltiorrhizae 1540g, Radix Notoginseng 750g, Lignum Dalbergiae Odoriferae oil 14.5ml, xylitol 450g, arabic gum 59g is standby;
(b): above three flavors, Radix Salviae Miltiorrhizae ethanol extraction secondary, each 60 minutes, filter, filtrate merges, and recovery ethanol also continues to be concentrated into the clear paste of relative density 1.20~1.25 (60 ℃ of surveys), and is standby; Radix Notoginseng powder is broken into coarse powder, 70% alcohol reflux secondary, each 1.5 hours, merge extractive liquid, filters filtrate recycling ethanol, and continue to be concentrated into the clear paste of relative density 1.20~1.25 (60 ℃ of surveys), add a spot of kieselguhr, (80 ℃) are evaporated to the clear paste of relative density 1.20~1.25 (60 ℃ of surveys), and are standby;
(c): in xylitol and arabic gum mixture, add above-mentioned Radix Salviae Miltiorrhizae and Radix Notoginseng extractum, Lignum Dalbergiae Odoriferae oil, fully mix, mixture stirs at 100 ℃ of heating and meltings, mixing time is 3 minutes, insulation is 1.1~2.5 millimeters at 95 ℃ of temperature following system, dropper bore, splashes in 8~12 ℃ the liquid paraffin, liquid coolant is use up and wiped to the drop pill drop that forms, pour in the dish that is lined with absorbent paper, back packing to be dried is made 1000g promptly.
Embodiment 12
(a): get Radix Salviae Miltiorrhizae 1350g, Radix Notoginseng 600g, Lignum Dalbergiae Odoriferae oil 15ml, xylitol 500g, Furcellaran 90g, methylcellulose 55g are standby;
(b): above three flavors, Radix Salviae Miltiorrhizae ethanol extraction secondary, each 70 minutes, filter, filtrate merges, and recovery ethanol also continues to be concentrated into the clear paste of relative density 1.15 (60 ℃ of surveys), and is standby; Radix Notoginseng powder is broken into coarse powder, 80% alcohol reflux secondary, each 2 hours, merge extractive liquid, filters filtrate recycling ethanol, and continue to be concentrated into the clear paste of relative density 1.10~1.15 (70 ℃ of surveys), add a spot of kieselguhr, (70 ℃) are evaporated to the clear paste of relative density 1.15~1.25 (60 ℃ of surveys), and are standby;
(c): in xylitol, Furcellaran and methylcellulose mixture, add above-mentioned Radix Salviae Miltiorrhizae and Radix Notoginseng extractum, Lignum Dalbergiae Odoriferae oil, fully mix, mixture stirs at 90 ℃ of heating and meltings, and mixing time is 10~30 minutes, insulation, be 1.1~3.5 millimeters at 85 ℃ of temperature following system, dropper bore and splash in-5~8 ℃ the methyl-silicone oil, with the drop pill drop that forms to the greatest extent and wipe liquid coolant, pour in the dish that is lined with absorbent paper, back packing to be dried is made 1000g promptly.
Embodiment 13
(a): get Radix Salviae Miltiorrhizae 650g, Radix Notoginseng 1800g, Lignum Dalbergiae Odoriferae oil 5.5ml, sorbitol 650g, xanthan gum 50g, modified starch, 95g is standby;
(b): above three flavors, Radix Salviae Miltiorrhizae ethanol extraction secondary, each 90 minutes, filter, filtrate merges, and reclaims ethanol and continues to be condensed into clear paste, and is standby; Radix Notoginseng powder is broken into coarse powder, 80~95% alcohol reflux secondaries, and each 3 hours, merge extractive liquid, filtered, filtrate recycling ethanol, and continue to be condensed into clear paste, and adding a spot of kieselguhr, concentrating under reduced pressure becomes clear paste, and is standby;
(c): in sorbitol, xanthan gum and modified starch mixture, add above-mentioned Radix Salviae Miltiorrhizae and Radix Notoginseng extractum, Lignum Dalbergiae Odoriferae oil, fully mix, mixture stirs at 60~85 ℃ of heating and meltings, and mixing time is 10~30 minutes, insulation, be 1.1~2.5 millimeters at 60~85 ℃ of temperature following system, dropper bore and splash in 8~12 ℃ the liquid paraffin, with the drop pill drop that forms to the greatest extent and wipe liquid coolant, pour in the dish that is lined with absorbent paper, back packing to be dried is made 1000g promptly.
Embodiment 14
(a): get Radix Salviae Miltiorrhizae 1500g, Radix Notoginseng 870g, Lignum Dalbergiae Odoriferae oil 12.5ml, xylitol 350g, chitin 250g is standby;
(b): above three flavors, Radix Salviae Miltiorrhizae ethanol extraction secondary, each 70 minutes, filter, filtrate merges, and recovery ethanol also continues to be concentrated into the clear paste of relative density 1.20~1.25 (60 ℃ of surveys), and is standby; Radix Notoginseng powder is broken into coarse powder, 70% alcohol reflux secondary, each 1.5 hours, merge extractive liquid, filters filtrate recycling ethanol, and continue to be concentrated into the clear paste of relative density 1.20~1.25 (60 ℃ of surveys), add a spot of kieselguhr, (80 ℃) are evaporated to the clear paste of relative density 1.20~1.25 (60 ℃ of surveys), and are standby;
(c) in xylitol and chitin mixture, add above-mentioned Radix Salviae Miltiorrhizae and Radix Notoginseng extractum, Lignum Dalbergiae Odoriferae oil, fully mix, mixture stirs at 75 ℃ of heating and meltings, and mixing time is 20 minutes, insulation, be 1.4~2.5 millimeters at 75 ℃ of temperature following system, dropper bore and splash in 0 ℃ the liquid paraffin, with the drop pill drop that forms to the greatest extent and wipe liquid coolant, pour in the dish that is lined with absorbent paper, back packing to be dried is made 1000g promptly.
Embodiment 15
(a): get Radix Salviae Miltiorrhizae 1110g, Radix Notoginseng 1200g, Lignum Dalbergiae Odoriferae oil 13ml, sorbitol 535g, sodium stearate 65g, cyclodextrin 115g are standby;
(b): above three flavors, Radix Salviae Miltiorrhizae ethanol extraction secondary, each 90 minutes, filter, filtrate merges, and recovery ethanol and continuing is concentrated at 60 ℃, the clear paste of relative density 1.15~1.35, and is standby; Radix Notoginseng powder is broken into coarse powder, 80% alcohol reflux secondary, each 3 hours, merge extractive liquid, filters filtrate recycling ethanol, and continue to be concentrated at 60 ℃, the clear paste of relative density 1.25~1.35, add a spot of kieselguhr, be evaporated at 60 ℃, the clear paste of relative density 1.25~1.35, standby;
(c): in sorbitol, cyclodextrin and sodium stearate mixture, add above-mentioned Radix Salviae Miltiorrhizae and Radix Notoginseng extractum, Lignum Dalbergiae Odoriferae oil, fully mix, mixture stirs at 64 ℃ of heating and meltings, mixing time is 10~30 minutes, insulation is 1.25~2.5 millimeters at 64 ℃ of temperature following system, dropper bore, splashes in 8~12 ℃ the liquid paraffin, liquid coolant is use up and wiped to the drop pill drop that forms, pour in the dish that is lined with absorbent paper, back packing to be dried is made 1000g promptly.
Embodiment 16
(a): get Radix Salviae Miltiorrhizae 900g, Radix Notoginseng 700g, Lignum Dalbergiae Odoriferae oil 8ml, xylitol 600g, alginic acid 73g is standby;
(b): above three flavors, Radix Salviae Miltiorrhizae ethanol extraction secondary, each 75 minutes, filter, filtrate merges, and recovery ethanol and continuing is concentrated at 60 ℃, the clear paste of relative density 1.05~1.15, and is standby; Radix Notoginseng powder is broken into coarse powder, 75% alcohol reflux secondary, each 2.5 hours, merge extractive liquid, filters filtrate recycling ethanol, and continue to be concentrated at 60 ℃, the clear paste of relative density 1.05~1.15, add a spot of kieselguhr, be evaporated at 60 ℃, the clear paste of relative density 1.25~1.35, standby;
(c): in xylitol, alginic acid mixture, add above-mentioned Radix Salviae Miltiorrhizae and Radix Notoginseng extractum, Lignum Dalbergiae Odoriferae oil, fully mix, mixture stirs at 80 ℃ of heating and meltings, and mixing time is 10~30 minutes, insulation, be 2.0~3.5 millimeters at 64 ℃ of temperature following system, dropper bore and splash in 12~20 ℃ the methyl-silicone oil, with the drop pill drop that forms to the greatest extent and wipe liquid coolant, pour in the dish that is lined with absorbent paper, back packing to be dried is made 1000g promptly.
Embodiment 17
Supercritical extraction Radix Salviae Miltiorrhizae, Radix Notoginseng get extractum respectively.
Radix Salviae Miltiorrhizae extractum 8.5g, Radix Notoginseng extractum 5.5g, Lignum Dalbergiae Odoriferae oil 10.5ml, xylitol 18.5g, starch 3.5g;
With xylitol and the abundant mixing of starch, put into drop pill and drip the system device, add Radix Salviae Miltiorrhizae and Radix Notoginseng extractum, Lignum Dalbergiae Odoriferae oil, fully mix, mixture stirs at 60~85 ℃ of heating and meltings, and mixing time is 10~30 minutes, insulation, be 1.2~2.5 millimeters at 60~85 ℃ of temperature following system, dropper bore and splash in 8~12 ℃ the liquid paraffin, with the drop pill drop that forms to the greatest extent and wipe liquid coolant, pour in the dish that is lined with absorbent paper, back packing to be dried is made 1000 promptly.
The result shows, prepared drop pill rounding, even, consistent, the no adhesion phenomenon of color and luster of size.By measuring under Chinese Pharmacopoeia version in 2000 the method disintegration item, the result does not add baffle plate and passed through screen cloth in average 2.52 minutes, meets the pharmacopeia regulation this disintegration.
Embodiment 18
Supercritical extraction Radix Salviae Miltiorrhizae, Radix Notoginseng get extractum respectively.
Radix Salviae Miltiorrhizae extractum 200g, Radix Notoginseng extractum 133g, Lignum Dalbergiae Odoriferae oil 10.5ml, xylitol 551.2gg, starch 115.9g;
With xylitol and the abundant mixing of starch, put into drop pill and drip the system device, add Radix Salviae Miltiorrhizae and Radix Notoginseng extractum, Lignum Dalbergiae Odoriferae oil, fully mix, mixture stirs at 64 ℃ of heating and meltings, and mixing time is 10~30 minutes, insulation, be 1.2~2.5 millimeters at 64 ℃ of temperature following system, dropper bore and splash in 5 ℃ the liquid paraffin, with the drop pill drop that forms to the greatest extent and wipe liquid coolant, pour in the dish that is lined with absorbent paper, back packing to be dried is made 1000g promptly.The result shows, prepared drop pill rounding, even, consistent, the no adhesion phenomenon of color and luster of size.By measuring under Chinese Pharmacopoeia version in 2000 the method disintegration item, the result does not add baffle plate and passed through screen cloth in average 2.22 minutes, meets the pharmacopeia regulation this disintegration.
Embodiment 19
Supercritical extraction Radix Salviae Miltiorrhizae, Radix Notoginseng get extractum respectively.
Radix Salviae Miltiorrhizae extractum 130g, Radix Notoginseng extractum 70g, Lignum Dalbergiae Odoriferae oil 15.5ml, xylitol 640g, starch 160g;
With xylitol and the abundant mixing of starch, put into drop pill and drip the system device, add extractum, Lignum Dalbergiae Odoriferae oil, fully stir evenly, heating in water bath, to fusion, bath temperature is 85 ℃.Under 65 ℃ of insulations fused mass being splashed into temperature with 35 droplets/minute speed is in 0 ℃ the liquid paraffin liquid coolant, makes the 1000g drop pill, and back to be formed is with inhaling the liquid paraffin that the paper suction goes to stick to the drop pill surface, and cold drying promptly.

Claims (12)

1. treat treating coronary heart disease and angina pectoris for one kind, it is characterized in that it is to be made by Radix Salviae Miltiorrhizae 600~1800g, Radix Notoginseng 600~1800g, Lignum Dalbergiae Odoriferae oil 5~16ml, appropriate amount of auxiliary materials, wherein adjuvant comprises filler and plasticity substrate, said filler is selected from the natural adjuvant of following one or more plant origins: sorbitol, xylitol, lactose, and they contain the water of crystallization chemical compound; Said plasticity substrate is selected from the natural adjuvant of following one or more plant origins: starch and derivant thereof, cellulose and derivant thereof, arabic gum, chitin, Furcellaran, xanthan gum, alginic acid and salt thereof, cyclodextrin; Described filler is 1: 0.1~1: 0.9 with the ratio of the weight of plasticizer.
2. treatment treating coronary heart disease and angina pectoris as claimed in claim 1, it is characterized in that it is to be made by Radix Salviae Miltiorrhizae 1000~1400g, Radix Notoginseng 1000~1400g, Lignum Dalbergiae Odoriferae oil 8~12ml, appropriate amount of auxiliary materials, filler adjuvant wherein is selected from following one or more the natural adjuvant of plant origin: sorbitol, xylitol, lactose, and they contain the water of crystallization chemical compound; Plasticity substrate wherein is selected from following one or more the natural adjuvant of plant origin: starch, methylcellulose, arabic gum, alginic acid, cyclodextrin; Described filler is 1: 0.1~1: 0.5 with the ratio of the weight of plasticizer.
3. treatment treating coronary heart disease and angina pectoris as claimed in claim 2, it is characterized in that it is to be made by Radix Salviae Miltiorrhizae 1200g, Radix Notoginseng 1200g, Lignum Dalbergiae Odoriferae oil 10.5ml, appropriate amount of auxiliary materials, filler adjuvant wherein is selected from following one or more the natural adjuvant of plant origin: xylitol, lactose; Plasticity substrate wherein is selected from following one or more the natural adjuvant of plant origin: starch, arabic gum; Described filler is 1: 0.1~1: 0.5 with the ratio of the weight of plasticizer.
4. treatment treating coronary heart disease and angina pectoris as claimed in claim 3 is characterized in that described adjuvant is xylitol and starch, and xylitol is 1: 0.2~1: 0.3 with the ratio of the weight of starch.
5. treatment treating coronary heart disease and angina pectoris as claimed in claim 3 is characterized in that described adjuvant is lactose and starch, and lactose is 1: 0.2~1: 0.3 with the ratio of the weight of starch.
6. treatment treating coronary heart disease and angina pectoris as claimed in claim 3 is characterized in that described adjuvant is xylitol and arabic gum, and the ratio of the weight of xylitol and arabic gum is 1: 0.2~1: 0.4.
7. as claim 1,2 or 3 described treatment treating coronary heart disease and angina pectoris, it is characterized in that the adjuvant and the ratio of the weight of extract drugs extractum are 1: 0.1~1: 1.
8. as claim 1,2 or 3 described treatment treating coronary heart disease and angina pectoris, it is characterized in that the adjuvant and the ratio of the weight of extract drugs extractum are 1: 0.1~1: 0.6.
9. as claim 1,2 or 3 described treatment treating coronary heart disease and angina pectoris, it is characterized in that the adjuvant and the ratio of the weight of extract drugs extractum are 1: 0.2~1: 0.4.
10. the preparation method of claim 1,2 or 3 described treatment angina pectoris medicines is characterized in that this method comprises the steps:
(a): get Radix Salviae Miltiorrhizae 600~1800g, Radix Notoginseng 600~1800g, Lignum Dalbergiae Odoriferae oil 5~16ml is standby;
(b): above three flavors, Radix Salviae Miltiorrhizae ethanol extraction secondary, each 30~180 minutes, filter, filtrate merges, and reclaims ethanol and continues to be condensed into clear paste, and is standby; Radix Notoginseng powder is broken into coarse powder, 50~95% alcohol reflux secondaries, and each 0.5~4 hour, merge extractive liquid, filtered, filtrate recycling ethanol, and continue to be condensed into clear paste, and adding a spot of kieselguhr, concentrating under reduced pressure becomes clear paste, and is standby;
(c): in appropriate amount of auxiliary materials, add above-mentioned Radix Salviae Miltiorrhizae and Radix Notoginseng extractum, Lignum Dalbergiae Odoriferae oil, fully mix, mixture is at 45~115 ℃ of heating and meltings, stir, mixing time is 1~120 minute, insulation, at 45~95 ℃ of temperature following system, dropper bore is 1.0~4.0 millimeters, splash in-20~25 ℃ liquid paraffin, methyl-silicone oil or the vegetable oil, make drop pill, promptly.
11. the preparation method of treatment angina pectoris medicine as claimed in claim 10 is characterized in that this method comprises the steps:
(a): get Radix Salviae Miltiorrhizae 1000~1400g, Radix Notoginseng 1000~1400g, Lignum Dalbergiae Odoriferae oil 8~12ml is standby;
(b): above three flavors, Radix Salviae Miltiorrhizae ethanol extraction secondary, each 60~90 minutes, filter, filtrate merges, and recovery ethanol and continuing is concentrated at 60 ℃, the clear paste of relative density 1.05~1.35, and is standby; Radix Notoginseng powder is broken into coarse powder, 60~80% alcohol reflux secondaries, each 2~3 hours, merge extractive liquid, filters filtrate recycling ethanol, and continue to be concentrated at 60 ℃, the clear paste of relative density 1.05~1.35, add a spot of kieselguhr, be evaporated at 60 ℃, the clear paste of relative density 1.05~1.35, standby;
(c): in appropriate amount of auxiliary materials, add above-mentioned Radix Salviae Miltiorrhizae and Radix Notoginseng extractum, Lignum Dalbergiae Odoriferae oil, fully mix, mixture stirs at 60~85 ℃ of heating and meltings, mixing time is 10~30 minutes, insulation is 1.1~3.5 millimeters at 60~85 ℃ of temperature following system, dropper bore, splashes in 0~18 ℃ the liquid paraffin, methyl-silicone oil, liquid coolant is use up and wiped to the drop pill drop that forms, back packing to be dried is made the 1000g drop pill, promptly.
12. the preparation method of treatment angina pectoris medicine as claimed in claim 11 is characterized in that this method comprises the steps:
(a): get Radix Salviae Miltiorrhizae 1200g, Radix Notoginseng 1200g, Lignum Dalbergiae Odoriferae oil 10.5ml is standby;
(b): above three flavors, Radix Salviae Miltiorrhizae ethanol extraction secondary, each 70 minutes, filter, filtrate merges, and recovery ethanol and continuing is concentrated at 60 ℃, the clear paste of relative density 1.20~1.25, and is standby; Radix Notoginseng powder is broken into coarse powder, 70% alcohol reflux secondary, each 1.5 hours, merge extractive liquid, filters filtrate recycling ethanol, and continue to be concentrated into the clear paste of relative density 1.20~1.25 (60 ℃ of surveys), add a spot of kieselguhr, be evaporated under 80 ℃ of conditions at 60 ℃, the clear paste of relative density 1.20~1.25, standby;
(c): in appropriate amount of auxiliary materials, add above-mentioned Radix Salviae Miltiorrhizae and Radix Notoginseng extractum, Lignum Dalbergiae Odoriferae oil, fully mix, mixture stirs at 64 ℃ of heating and meltings, mixing time is 10~30 minutes, insulation is 1.2~2.5 millimeters at 64 ℃ of temperature following system, dropper bore, splashes in 0 ℃ the methyl-silicone oil, liquid coolant is use up and wiped to the drop pill drop that forms, back packing to be dried is made the 1000g drop pill, promptly.
CNB2003101073069A 2003-12-11 2003-12-11 Medication for treating coronary heart disease and angina Expired - Fee Related CN100421684C (en)

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CN101336961B (en) * 2008-08-14 2011-12-28 中发实业集团业锐药业有限公司 Coronary heart disease drop pill and preparation method thereof
CN103784504B (en) * 2014-01-24 2016-01-13 中发实业集团业锐药业有限公司 A kind of Chinese medicine composition and preparation method thereof

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