CN102441286B - Method for improving melt wall sticking during spray drying of traditional Chinese medicine or food raw material - Google Patents
Method for improving melt wall sticking during spray drying of traditional Chinese medicine or food raw material Download PDFInfo
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- CN102441286B CN102441286B CN201010298981.4A CN201010298981A CN102441286B CN 102441286 B CN102441286 B CN 102441286B CN 201010298981 A CN201010298981 A CN 201010298981A CN 102441286 B CN102441286 B CN 102441286B
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Abstract
The invention discloses a method for improving melt wall sticking during spray drying of a traditional Chinese medicine or food raw material by using MC (methylcellulose), HPC (hydroxypropyl cellulose) and HPMC (hydroxypropyl methylcellulose). The method comprises the following steps: adding any one, two or three auxiliary materials of MC, HPC and HPMC into a solution which is to be dried and has a solid content of lower than 50 percent, wherein the dosage of the auxiliary materials is 0.1 to 15 percent of the solid content of the solution to be dried; and uniformly stirring and dispersing, and performing spray drying under a stirring condition. The method has the advantages of small auxiliary material dosage, no side effect, no interference to release of main components of medicament, good repeatability and strong applicability, and can effectively improve the melt wall sticking problem in the spray drying process.
Description
Technical field
The invention belongs to drying technique field, be specifically related to a kind of method utilizing auxiliary material to improve Chinese medicine or raw-food material spraying dry melt wall sticking; Particularly relate to application MC (methylcellulose), HPC (hydroxypropyl cellulose), HPMC (Hydroxypropyl methylcellulose) improve the method for Chinese medicine or raw-food material spraying dry melt wall sticking.
Background technology
Spraying dry is the conventional drying method of Chinese medicine extract and raw-food material solution, has the advantage such as " instantaneous drying ", " dry products quality is good ", " dry run is simple ".But, due to the character reason of material itself, in spray-drying process, usually there is melt wall sticking phenomenon.Its principal phenomena produced is that spraying dry instrument inwall has droplet-like to lump, and is combined firmly, can not collects, mainly adhere in cyclone separator and collector with inwall.There are research [Huang Lixin, Zhou Ruijun, product glass transition pre-test in spray-drying process, universal machine, 2005,12:14-18; Pu deposit sea, Zhao Kaijun, Guan Zhiyu, etc., the research [J] that Chinese medical concrete softening point affects spraying dry, Chinese patent drug, 2006,28 (1): 18-20] display, this phenomenon be due to material powders softening point or glass transition temperature is low causes.As this material is adopted other drying means, pressure forced air drying as usual or vacuum drying, its phenomenon to be material be soft semisolid, can not be ground into powder, as by solid transfer to low temperature environment, soft material is hardening gradually.Such material mainly appears in Chinese medicine and food, and its softening point or the low reason of glass transition temperature may be the complicated components due to material, and fractions forms eutectic.
At present, the method improving spraying dry melt wall sticking mainly contains: transform spray drying device, increases attachment device, as adopted [Wang Xizhong, the Yu Caiyuan etc. such as chuck cooling tower wall, low temperature spray drying method, spraying dry [M], Beijing: Chemical Industry Press, 2003]; And auxiliary material is added in extract.Relative to chuck cooling method and low temperature spray drying method, adding auxiliary material method and have advantage in operability and performance driving economy, is therefore production at present improves powder glue the most widely used method of wall.Add in auxiliary material method, the kind of auxiliary material is comparatively conventional with soluble starch, maltodextrin, but when for improving melt wall sticking, consumption is general larger, generally can reach more than 50% [Xiao Dan, Bian Hongyan of dry cream amount in extract, drying process with atomizing research (J) Chinese herbal medicine of root of Dahurain angelica granule, 2006,37 (6): 874-876.].Supplementary product consumption is large, will certainly reduce the drugloading rate of prescription, thus cause the dose after preparations shaping excessive.Therefore, how to overcome the melt wall sticking in Chinese medicine extract spray-drying process, the consumption simultaneously reducing auxiliary material will seem most important.
The applicant is through research, develop a kind of method improving hot-melt wall sticking in spray drying process of traditional Chinese medicinal extracting solution, and apply for patent of invention, number of patent application is: 201010108021.7, the method can by adding a small amount of auxiliary material (i.e. light magnesium oxide, microcrystalline cellulose) in certain limit, reach the effect improving spraying dry melt wall sticking, and proved by multinomial experiment.But the method auxiliary material used, human intaking amount has a definite limitation, is therefore only applicable to be added in medicine, then can not arbitrarily add in food.In addition, experimental studies have found that through a large amount of, this auxiliary material still can not solve all melt wall sticking problems.Therefore, the applicant, in follow-up research, continues to find more optimal technical scheme.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of method improving Chinese medicine or raw-food material spraying dry melt wall sticking.Supplementary product consumption of the present invention is few, has no side effect, noiseless to the release of drug main composition, favorable reproducibility, and applicability is strong, effectively can improve the melt wall sticking problem in spray-drying process.
In order to solve the problems of the technologies described above, technical scheme provided by the invention is as follows:
A kind ofly apply methylcellulose, method that hydroxypropyl cellulose, Hydroxypropyl methylcellulose improve Chinese medicine or raw-food material spraying dry melt wall sticking, comprise the steps: to solid content be add in 50% (mass/volume percentage) solution to be dried below in methylcellulose, hydroxypropyl cellulose and Hydroxypropyl methylcellulose any one, two or three auxiliary material, the consumption adding auxiliary material is the 0.1-15% of solution solid content to be dried, and dispersed with stirring evenly also carries out spraying dry under agitation.
The model of described Hydroxypropyl methylcellulose comprises E type, K type and F type, and preferred model is E type.
Described solution to be dried is Chinese medicine extract or raw-food material solution.Such as, potenlin side's extract, blue a kind of reed mentioned in ancient books side extract, clear pouring side extract, date extract, tuber of dwarf lilyturf extract, medlar extract liquid, root of Dahurain angelica extract, vegetable oil emulsion, whole milk, soybean lecithin emulsion etc.
The described consumption adding auxiliary material is the 0.1-15% of solution solid content to be dried, and preferred proportion is 1-10%.Solid content refers to amount of solid contained by solution to be dried, and the dry cream amount namely in solution to be dried, the percentage of solid content refers to mass/volume percentage.
Auxiliary material of the present invention is: MC (methylcellulose), HPC (hydroxypropyl cellulose), HPMC (Hydroxypropyl methylcellulose).These three kinds of materials belong to general pharmaceutic adjuvant, mainly emulsifying agent, stabilizing agent, suspending agent, thickener, binder, film forming agent, ointment base etc. are used as at medicine and food service industry, or prepare matrix sustained release tablet as framework material, slow-release pill and double-layer sustained release tablets.But never for improving spraying dry melt wall sticking.
The present invention's beneficial effect is compared with prior art: 1. the present invention's auxiliary material MC (methylcellulose) used, HPC (hydroxypropyl cellulose), HPMC (Hydroxypropyl methylcellulose) are to human-body safety, have no side effect, may be used for medicine, also may be used for raw-food material, expand range of application, there is larger using value and invention meaning; 2. the invention solves 201010108021.7 patent application an open questions, namely for improving melt wall sticking, there is more general applicability, research so far, the method can solve the problem of all spraying dry melt wall stickings, as the melt wall sticking problem for date extract, the method adopting 201010108021.7 patent applications to record, can not improve its melt wall sticking problem, and application the inventive method then can solve its melt wall sticking phenomenon completely; 3. the consumption of the present invention's auxiliary material used few (only accounting for the 0.1-15% of amount of solid contained by solution to be dried), can reduce costs, have good economic benefit; 4. the release of the present invention's auxiliary material used to medicine or food principal component is noiseless, and favorable reproducibility, applicability is strong.
Detailed description of the invention
Below in conjunction with specific embodiment, set forth the present invention further.These embodiments are interpreted as only being not used in for illustration of the present invention limiting the scope of the invention.After the content of having read the present invention's record, those skilled in the art can make various changes or modifications the present invention, and these equivalence changes and modification fall into the scope of the claims in the present invention equally.
Embodiment 1: improve potenlin side's extract spraying dry melt wall sticking
Potenlin side records kind for " the Sanitation Ministry medicine standard Traditional Chinese medicine historical preparation " the 10th, is formed through Hydrolysis kinetics by wilsonii and the fruit of Chinese wolfberry 2 taste Chinese medicine.Find in an experiment, there is melt wall sticking when spraying dry in its extract, powder yield is almost nil.
Method of the present invention is adopted to be: potenlin side concentratedly obtains potenlin side extract 500ml (solid content: 10.7%) through suitably extracting; Add the E type HPMC4.3g accounting for extract solid content 8%, be stirred to dissolve and be uniformly dispersed, and carry out spraying dry (BUCHI-B290 spraying dry instrument under agitation, technological parameter is set to: EAT 125 DEG C, atomizing pressure 50mm, feed liquor speed 25%, intake volume 100%), parallel three batches, the yield average out to 93% of spray-dried powders, effectively improves potenlin extract spraying dry melt wall sticking problem.
Adopt version Chinese Pharmacopoeia two annex XC the 3rd method small-radius curve track in 2005 to investigate the release of principal component Syringin in potenlin extract spray-dried powders, the preparation of Syringin after 15min, more than 75%, meets release requirement.
Embodiment 2: improve blue a kind of reed mentioned in ancient books side extract spraying dry melt wall sticking
Blue a kind of reed mentioned in ancient books side is that national ministry standard is included (WS-214 (Z-033)-96), blue a kind of reed mentioned in ancient books side extract 450ml (solid content: 11.7%) is obtained through suitably extracting to concentrate, add the MC3.2g accounting for dry cream amount 6% in extract wherein, be stirred to dissolve and be uniformly dispersed, and carry out spraying dry (BUCHI-B290 spraying dry instrument under agitation, technological parameter is set to: EAT 130 DEG C, atomizing pressure 55mm, feed liquor speed 30%, intake volume 100%), parallel three batches, the yield average 92% of spray-dried powders.
Adopt version Chinese Pharmacopoeia two annex XC the 3rd method small-radius curve track in 2005 to investigate the release of principal component Gardenoside in blue a kind of reed mentioned in ancient books extract spray-dried powders, the preparation of Gardenoside after 15min, more than 75%, meets release requirement.
Embodiment 3: improve clear pouring (particle) square spraying dry melt wall sticking
Clear pouring (particle) side includes (WS3-B-1237-92) for national ministry standard, through suitably extracting the concentrated side's drenched extract 450ml (solid content: 12.0%) clearly, add the HPC1.6g accounting for dry cream amount 3% in extract wherein, stirring makes to be uniformly dispersed, and carry out spraying dry (BUCHI-B290 spraying dry instrument under agitation, technological parameter is set to: EAT 125 DEG C, atomizing pressure 55mm, feed liquor speed 25%, intake volume 100%), the yield of powder brings up to 90% by 35%.
Version Chinese Pharmacopoeia two annex XC the 3rd method small-radius curve track in 2005 is adopted to investigate clear release of drenching principal component Gardenoside in (particle) square extract spray-dried powders, the preparation of Gardenoside after 15min, more than 75%, meets release requirement.
Embodiment 4: improve date extract spraying dry melt wall sticking comparative example
Date belongs to the food of integration of drinking and medicinal herbs, and its extract is usually used alone or makes an addition in other health food, plays tonifying middle-Jiao and Qi, the effect of nourishing blood and tranquilization, but serious melt wall sticking appears in its extract spray-drying process, and receiving powder rate is zero.The method adopting 201010108021.7 patent applications to record carries out antiseized wall research, improves the DeGrain of sticky wall.
Date obtains extract 1000ml (solid content: 22%) through suitably extracting to concentrate, be divided into two parts, add the F type HPMC0.1g, the 2% light magnesium oxide 2.2g that account for the dry cream amount 0.1% of extract respectively, stir respectively and make to be uniformly dispersed, and carry out under agitation spraying dry (BUCHI-B290 spraying dry instrument, technological parameter is set to: EAT 120 DEG C, atomizing pressure 55mm, feed liquor speed 30%, intake volume 100%).The yield adding the sample powder of F type HPMC reaches 85% (effect that the present invention improves sticky wall is good), and the yield adding the sample powder of light magnesium oxide is zero (method adopting 201010108021.7 patent applications to record improves the DeGrain of sticky wall).Therefore, for date extract, the inventive method is better than the method that 201010108021.7 patent applications are recorded.
Embodiment 5: improve tuber of dwarf lilyturf extract spraying dry melt wall sticking
The tuber of dwarf lilyturf makes an addition to common drug in health food, plays nourishing Yin and moistening lung; The effect of reinforcing stomach reg fluid, but there is serious melt wall sticking in its extract spray-drying process, receives powder rate and only have 10%.The tuber of dwarf lilyturf obtains extract 600ml (solid content: 12.0%) through suitably extracting to concentrate, add the HPC0.7g accounting for the dry cream amount 1% of extract, dissolve and stir and make to be uniformly dispersed, carry out spraying dry (BUCHI-B290 spraying dry instrument under agitation, technological parameter is set to: EAT 120 DEG C, atomizing pressure 50mm, feed liquor speed 20%, intake volume 100%), the yield of powder reaches 90%.
Embodiment 6: improve medlar extract liquid spraying dry melt wall sticking
The fruit of Chinese wolfberry belongs to the food of integration of drinking and medicinal herbs, and its extract is usually used alone or makes an addition in other health food, plays nourishing liver and kidney, the effect of benefiting shrewd head, but serious melt wall sticking appears in its extract spray-drying process, and receiving powder rate is zero.
The fruit of Chinese wolfberry obtains extract 500ml (solid content: 15%) through suitably extracting to concentrate, add and account for the dry cream amount 6%MC4.5g of extract, be stirred to dissolve respectively and be uniformly dispersed, carry out spraying dry (BUCHI-B290 spraying dry instrument under agitation, technological parameter is set to: EAT 125 DEG C, atomizing pressure 50mm, feed liquor speed 25%, intake volume 100%), the yield of powder reaches 95%.
Embodiment 7: mixed accessories improves potenlin side's extract spraying dry melt wall sticking
Potenlin side obtains potenlin side extract 300ml (solid content: 10.7%), parallel 7 parts through suitably extracting to concentrate; Respectively to adding the E type HPMC and MC 3g altogether that account for extract solid content 9% in extract, wherein the ratio of E type HPMC and MC is in table 1, be stirred to dissolve and be uniformly dispersed, carry out spraying dry (BUCHI-B290 spraying dry instrument under agitation, technological parameter is set to: EAT 120 DEG C, atomizing pressure 55mm, feed liquor speed 15%, intake volume 100%).
Table 1
From table 1, E type HPMC and MC arbitrary proportion all effectively can improve potenlin extract melt wall sticking problem, and ratio change is little on the impact of powder yield, but used in combination, and powder yield is improved trend.
Embodiment 8: mixed accessories improves blue a kind of reed mentioned in ancient books side extract spraying dry melt wall sticking
Blue a kind of reed mentioned in ancient books side extract (solid content: 11.7%) 250ml is obtained through suitably extracting to concentrate, parallel 5 parts, respectively to wherein adding MC and the HPC 3.2g altogether accounting for dry cream amount 11% in extract, wherein the ratio of MC and HPC is in table 2, is stirred to dissolve and is uniformly dispersed, and carries out spraying dry (BUCHI-B290 spraying dry instrument under agitation, technological parameter is set to: EAT 130 DEG C, atomizing pressure 55mm, feed liquor speed 30%, intake volume 100%).
Table 2
From table 2, HPC and MC arbitrary proportion all effectively can improve blue a kind of reed mentioned in ancient books side extract melt wall sticking problem, and raise with MC ratio, powder yield slightly improves.
Embodiment 9: mixed accessories improves clear pouring (particle) square spraying dry melt wall sticking
Clear pouring (particle) side is through suitably extracting the concentrated side's drenched extract 250ml (solid content: 12.0%), parallel 5 parts clearly.Add the K type HPMC that accounts for dry cream amount 5% in extract and HPC wherein and amount to 1.5g, wherein the ratio of HPMC and HPC is in table 3, be stirred to dissolve and be uniformly dispersed, carry out spraying dry (BUCHI-B290 spraying dry instrument under agitation, technological parameter is set to: EAT 125 DEG C, atomizing pressure 55mm, feed liquor speed 25%, intake volume 100%).
Table 3
From table 3, HPMC and HPC arbitrary proportion all effectively can improve the side's of pouring extract melt wall sticking problem clearly, and used in combination, powder yield slightly reduces.
Embodiment 10: mixed accessories improves root of Dahurain angelica extract spraying dry melt wall sticking
The root of Dahurain angelica is conventional Chinese medicine, during its extract spraying dry, serious melt wall sticking can occur.Adopt this method: angelica root obtains extract 150ml, (solid content: 17%), parallel 4 parts through suitably extracting to concentrate; Add the E type HPMC, HPC and MC that account for extract solid content 6%, amount to 1.5g, wherein the ratio of HPMC, MC, HPC is in table 4, be stirred to dissolve and be uniformly dispersed, carry out under agitation spraying dry (BUCHI-B290 spraying dry instrument, technological parameter is set to: EAT 120 DEG C, atomizing pressure 55mm, feed liquor speed 25%, intake volume 100%).
Adopt version Chinese Pharmacopoeia two annex XC the 3rd method small-radius curve track in 2005 to investigate the release of principal component Imperatorin in root of Dahurain angelica extract spray-dried powders, the preparation of Imperatorin after 15min more than 75%, should meet release requirement.
Table 4
From table 4, HPMC, HPC and MC arbitrary proportion all effectively can improve root of Dahurain angelica extract melt wall sticking problem, powder yield there was no significant difference used in combination.
Embodiment 11: mixed accessories improves tuber of dwarf lilyturf extract spraying dry melt wall sticking
The tuber of dwarf lilyturf obtains extract 250ml (solid content: 12.0%) through suitably extracting to concentrate, parallel 5 parts, add the K type HPMC that accounts for the dry cream amount 8% of extract and HPC and amount to 2.4g, wherein the ratio of HPMC and HPC is in table 5, is stirred to dissolve and is uniformly dispersed, and carries out spraying dry (BUCHI-B290 spraying dry instrument under agitation, technological parameter is set to: EAT 120 DEG C, atomizing pressure 50mm, feed liquor speed 20%, intake volume 100%).
Table 5
From table 5, HPMC and HPC arbitrary proportion all effectively can improve tuber of dwarf lilyturf extract melt wall sticking problem, and powder yield used in combination slightly improves.
Embodiment 12: mixed accessories improves date extract spraying dry melt wall sticking
Date obtains extract 250ml (solid content: 22%) through suitably extracting to concentrate, parallel 5 parts, add the E type HPMC that accounts for the dry cream amount 5% of extract and MC respectively and amount to 2.8g, wherein the ratio of HPMC and MC is in table 6, stirs respectively and makes to be uniformly dispersed, and carry out spraying dry (BUCHI-B290 spraying dry instrument under agitation, technological parameter is set to: EAT 120 DEG C, atomizing pressure 55mm, feed liquor speed 30%, intake volume 100%).
Table 6
From table 6, HPMC and MC arbitrary proportion all effectively can improve date extract melt wall sticking problem, and ratio change is little on the impact of powder yield.
Embodiment 13: mixed accessories improves medlar extract liquid spraying dry melt wall sticking
The fruit of Chinese wolfberry obtains extract 200ml (solid content: 15%) through suitably extracting to concentrate, parallel 7 parts, add the E type HPMC, HPC and MC4.5g that account for the dry cream amount 15% of extract respectively, wherein the ratio of HPMC, HPC and MC is in table 7, is stirred to dissolve respectively and is uniformly dispersed, and carries out spraying dry (BUCHI-B290 spraying dry instrument under agitation, technological parameter is set to: EAT 125 DEG C, atomizing pressure 50mm, feed liquor speed 25%, intake volume 100%).
Table 7
From table 7, HPMC, HPC and MC arbitrary proportion all effectively can improve medlar extract liquid melt wall sticking problem, powder yield there was no significant difference used in combination, and wherein HPC and MC mixing, can also improve the extract melt wall sticking problem of the fruit of Chinese wolfberry.
Embodiment 14: mixed accessories improves vegetable oil emulsion spraying dry melt wall sticking
Because the fusing point of hydrogenated vegetable oil is far above vegetable oil, for solving spraying dry melt wall sticking problem, vegetable fat powder obtains by hydrogenated vegetable oil.But modern study finds, a large amount of trans unrighted acid existed in hydrogenated vegetable oil is harmful, and the application of vegetable fat powder also enjoys suspection.Adopt this method, vegetable fat powder prepared by appliable plant oil, and effectively can improve the low spraying dry melt wall sticking phenomenon caused of vegetable oil fusing point, products obtained therefrom is more healthy.
Get vegetable oil emulsion 200ml (content of vegetable oil: 15%), parallel 11 parts, add the K type HPMC, HPC and MC3.6g that account for plant oil mass 12% respectively, wherein the ratio of HPMC, HPC and MC is in table 8, is stirred to dissolve respectively and is uniformly dispersed, and carries out spraying dry (BUCHI-B290 spraying dry instrument under agitation, technological parameter is set to: EAT 130 DEG C, atomizing pressure 45mm, feed liquor speed 20%, intake volume 100%).
Table 8
From table 8, do not add auxiliary material, vegetable oil emulsion spraying dry can not receive powdery product.HPMC, HPC and MC arbitrary proportion all effectively can improve vegetable oil emulsion melt wall sticking problem, powder yield there was no significant difference used in combination.Wherein HPC and MC mixing, HPMC and MC mixing, HPMC and HPC mixing, can also improve vegetable oil emulsion melt wall sticking problem.
Embodiment 15: improve whole milk spraying dry melt wall sticking
Can melt wall sticking be produced during whole milk spraying dry, affect the yield of milk powder to a certain extent, improve with this method, product yield and quality can be improved.
Get whole milk 500ml (solid content about: 9%), add the MC0.2g accounting for milk amount 0.4%, be stirred to dissolve respectively and be uniformly dispersed, carry out spraying dry (BUCHI-B290 spraying dry instrument under agitation, technological parameter is set to: EAT 135 DEG C, atomizing pressure 45mm, feed liquor speed 25%, intake volume 100%), the yield of powder is increased to 90% by 70%.
Embodiment 16: improve soybean lecithin spraying dry melt wall sticking
Soybean lecithin fusing point is lower, can produce melt wall sticking during spraying dry, can not obtain powdery product.By this method, powdered soy bean lecithin product can be obtained, be convenient to store and use.
Get soybean lecithin emulsion 250ml (solid content about: 10%), add the E type HPMC1.5g accounting for the dry cream amount 6% of extract, be stirred to dissolve respectively and be uniformly dispersed, carry out spraying dry (BUCHI-B290 spraying dry instrument under agitation, technological parameter is set to: EAT 110 DEG C of atomizing pressure 45mm, feed liquor speed 20%, intake volume 100%), can receive 70% powdered soy bean lecithin.
Embodiment 17: improve soybean lecithin spraying dry melt wall sticking
Get soybean lecithin emulsion 250ml (solid content about: 10%), add the HPC1.5g accounting for the dry cream amount 6% of extract, be stirred to dissolve respectively and be uniformly dispersed, carry out spraying dry (BUCHI-B290 spraying dry instrument under agitation, technological parameter is set to: EAT 110 DEG C of atomizing pressure 45mm, feed liquor speed 20%, intake volume 100%), can receive 65% powdered soy bean lecithin.
Claims (5)
1. one kind is improved the method for Chinese medicine or raw-food material spraying dry melt wall sticking, it is characterized in that, comprise the steps: to solid content be add in the solution to be dried of less than 50% in methylcellulose, hydroxypropyl cellulose and Hydroxypropyl methylcellulose any one, two or three auxiliary material, the consumption adding auxiliary material is the 0.1-15% of solution solid content to be dried, and dispersed with stirring evenly also carries out spraying dry under agitation.
2. the method improving Chinese medicine or raw-food material spraying dry melt wall sticking according to claim 1, is characterized in that, the model of described Hydroxypropyl methylcellulose comprises E type, K type and F type.
3. the method improving Chinese medicine or raw-food material spraying dry melt wall sticking according to claim 2, is characterized in that, the model of described Hydroxypropyl methylcellulose is E type.
4. the method improving Chinese medicine or raw-food material spraying dry melt wall sticking according to claim 1, is characterized in that, described solution to be dried is Chinese medicine extract or raw-food material solution.
5. the method improving Chinese medicine or raw-food material spraying dry melt wall sticking according to claim 1, is characterized in that, described in add auxiliary material consumption be the 1-10% of solution solid content to be dried.
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| CN116473926A (en) * | 2023-05-12 | 2023-07-25 | 河北地邦动物保健科技有限公司 | Preparation method of seven-ingredient stagnation-eliminating granule |
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| GB854949A (en) * | 1957-07-01 | 1960-11-23 | Kalle & Co Ag | Manufacture of polyvinyl resins in powder form |
| CN1334006A (en) * | 2001-08-21 | 2002-02-06 | 许惠朝 | Spray drying process for mancozeb |
| CN1483829A (en) * | 2003-06-12 | 2004-03-24 | 广州因赛生物科技有限公司 | Method for producing aclenosylmethionine by enzyme catalysis |
| CN1582733A (en) * | 2004-06-14 | 2005-02-23 | 张波 | Jujube flour making method |
| CN101862458A (en) * | 2010-06-21 | 2010-10-20 | 谭登平 | Auxiliary material combination for improving atomizing and drying process of traditional Chinese medicine granules and application thereof |
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB854949A (en) * | 1957-07-01 | 1960-11-23 | Kalle & Co Ag | Manufacture of polyvinyl resins in powder form |
| CN1334006A (en) * | 2001-08-21 | 2002-02-06 | 许惠朝 | Spray drying process for mancozeb |
| CN1483829A (en) * | 2003-06-12 | 2004-03-24 | 广州因赛生物科技有限公司 | Method for producing aclenosylmethionine by enzyme catalysis |
| CN1582733A (en) * | 2004-06-14 | 2005-02-23 | 张波 | Jujube flour making method |
| CN101862458A (en) * | 2010-06-21 | 2010-10-20 | 谭登平 | Auxiliary material combination for improving atomizing and drying process of traditional Chinese medicine granules and application thereof |
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