CN116473926A - Preparation method of seven-ingredient stagnation-eliminating granule - Google Patents
Preparation method of seven-ingredient stagnation-eliminating granule Download PDFInfo
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K35/64—Insects, e.g. bees, wasps or fleas
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- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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Abstract
The invention relates to a preparation method of seven-ingredient stagnation-removing particles, which comprises the following steps: step 1, crushing coix seeds and rice sprouts to obtain a particle mixture, adding water and amylase A into the particle mixture for enzymolysis, and filtering to obtain filtrate and residues; step 2, carrying out superfine grinding on periostracum cicadae by adopting a superfine grinder to prepare superfine powder, then adding water and compound enzyme into the superfine powder for enzymolysis, combining reaction liquid with the filtrate in the step 1 after enzymolysis, and carrying out spray drying to obtain powder, wherein the compound enzyme comprises amylase B and protease; step 3, decocting hawthorn, residues, lophatherum gracile, uncaria and liquorice in water for 2-3 times, merging decoction and concentrating to obtain thick paste; and step 4, adding powder into the thick paste, uniformly mixing, and granulating to obtain the seven-ingredient stagnation-removing granules. Compared with the traditional process, the invention avoids the problem of pot burning caused by high starch content in the direct decoction and extraction process, and improves the control effect of the seven-ingredient stagnation-eliminating particles.
Description
Technical Field
The invention belongs to the technical field of preparation of traditional Chinese medicine particles, and particularly relates to a preparation method of seven-ingredient stagnation-removing particles.
Background
The seven-ingredient stagnation-removing granule is mainly prepared from seven traditional Chinese medicines of coix seed, rice sprout, hawthorn, lophatherum gracile, uncaria, cicada slough and liquorice, has the effects of clearing heat and arresting convulsion and strengthening spleen to remove stagnation, and has obvious diarrhea effects on the gastrectasia food stagnation, dyspepsia and milk knot symptoms of calf and lamb. Has good treatment effect on diarrhea caused by bacterial and virus mixed infection. The feed supplement agent is clinically used for pre-early feed supplement and pre-and post-weaning, improves gastrointestinal functions, reduces intestinal stress caused by feed supplement and weaning to calves, ensures that calves are fed stably and weaned safely. The common preparation method of the seven-ingredient stagnation-eliminating granule comprises the steps of adding water into each raw material, decocting, carrying out an alcohol precipitation process, concentrating, and preparing into thick paste, wherein during the preparation process, the paste is easy to gelatinize in the decoction process because the coix seed and rice sprout contain a large amount of starch, the effective components are reduced, the overall quality and the treatment effect of the product are reduced, and the extraction cost and the extraction difficulty are increased.
Disclosure of Invention
The invention aims to overcome the defects in the prior art and provides a preparation method of seven-ingredient stagnation-removing particles, which is characterized in that coix seeds and rice sprouts are subjected to enzymolysis and residues are decocted, so that the problem of pot burning in the decoction process caused by high starch content in the coix seeds and rice sprouts in the traditional process is avoided.
In order to achieve the above purpose, the technical scheme adopted by the invention is as follows:
a preparation method of seven-ingredient stagnation-removing particles comprises the following steps:
step 1, crushing coix seeds and rice sprouts to obtain a particle mixture, adding water and amylase A into the particle mixture for enzymolysis, and filtering to obtain filtrate and residues;
step 2, carrying out superfine grinding on periostracum cicadae by adopting a superfine grinder to prepare superfine powder, then adding water and compound enzyme into the superfine powder for enzymolysis, combining reaction liquid with the filtrate in the step 1 after enzymolysis, and carrying out spray drying to obtain powder, wherein the compound enzyme comprises amylase B and protease;
step 3, taking hawthorn, lophatherum gracile, uncaria, liquorice and residues in the step 1, adding water for decoction for 2-3 times, merging decoction, and concentrating to 1.20-1.30 to obtain thick paste;
and step 4, adding the powder obtained in the step 2 into the thick paste, uniformly mixing, and granulating to obtain the seven-ingredient stagnation-eliminating granules.
As a further technical scheme, the particle size of the particle mixture in the step 1 is less than or equal to 0.60mm-0.85mm.
As a further technical scheme, in the step 1, the mass ratio of the particles to the water to the amylase A is 1 (2.5-3.5) (0.008-0.012); the amylase A comprises beta-amylase, and the enzymolysis condition is that the enzymolysis is carried out for 40-60min at 35-40 ℃.
As a further technical scheme, the amylase a further comprises alpha-amylase, and the mass ratio of the beta-amylase to the alpha-amylase is 2:1.
As a further technical scheme, in the step 2, the particle size of the superfine powder is less than or equal to 48 micrometers.
As a further technical scheme, the mass ratio of the superfine powder to the water to the complex enzyme is 1 (1.5-2.5):
(0.008-0.012); the complex enzyme is prepared by compounding amylase B and bromelain according to a mass ratio of 1:2; the enzymolysis conditions are as follows: enzymolysis is carried out for 50-60min at 50-55deg.C and pH of 6.2-7.2.
As a further embodiment, the amylase B is a beta-amylase.
As a further technical scheme, in step 2, the spray drying conditions are as follows: the air inlet temperature is 160-180 ℃ and the air outlet temperature is 60-70 ℃.
As a further technical scheme, in the step 3, hawthorn, residues, lophatherum gracile, uncaria and liquorice are added into water according to the mass-volume ratio of 1g to 5-10mL of the feed liquid.
Compared with the prior art, the invention has the beneficial effects that:
according to the invention, rice sprouts and coix seeds are subjected to enzymolysis by adopting beta-amylase to remove starch, and residues are decocted and extracted, so that compared with the traditional process, the problem of pot burning caused by high starch content in the direct decoction and extraction process is avoided, starch can be converted into active ingredient maltose through the enzymolysis of beta-amylase, starch waste is reduced, and the prevention and treatment effect of seven-ingredient stagnation-removing particles is improved;
in order to solve the problem, the invention carries out enzymolysis on the cicada slough after superfine grinding by alpha-amylase and bromelain, and carries out spray drying after mixing the enzymolysis products with the enzymolysis products of the rice sprout and the coix seed, thus avoiding the wall sticking phenomenon generated when the enzymolysis products of the rice sprout and the coix seed are independently spray dried. In addition, the invention also solves the problem that the traditional process has insufficient extraction of active ingredients caused by light weight of the cicada slough floating on the liquid surface during decoction and extraction, thereby reducing the effect of the medicine.
Detailed Description
The present invention will be described in further detail with reference to examples.
In the present invention,
alpha-amylase: nanning Donghenghua biological technology Limited liability company;
beta-amylase: the company of Hefei Wan biotechnology Co., ltd;
bromelain: nanning Donghenghua biological technology Limited liability company;
the seven-ingredient stagnation-eliminating granule comprises the following raw materials in parts by weight: 22.3 parts of hawthorn; 44.65 parts of coix seed; 44.65 parts of rice sprouts; 33.5 parts of lophatherum gracile; 16.75 parts of uncaria; 5.6 parts of cicada slough; 5.6 parts of liquorice.
The preparation method of the seven-ingredient stagnation-removing granule is characterized by comprising the following steps of:
step 1, crushing coix seeds and rice sprouts to obtain a particle mixture with the particle size of less than or equal to 0.60-0.85 mm, adding water and amylase A into the particle mixture according to the mass ratio of the particle mixture to water and amylase A of 1 (2.5-3.5) (0.008-0.012), carrying out enzymolysis for 40-60min at 35-40 ℃, and filtering to obtain filtrate and residues; the amylase A is prepared by compounding beta-amylase and alpha-amylase according to a mass ratio of 2:1;
step 2, carrying out superfine grinding on periostracum Cicadae by adopting a superfine grinder to prepare superfine powder with the particle size less than or equal to 48 microns, then adding water and compound enzyme into the superfine powder according to the mass ratio of (1.5-2.5) (0.008-0.012), regulating the pH value to be 6.2-7.2, carrying out enzymolysis for 50-60min at 50-55 ℃, merging the reaction solution with the filtrate in the step 1 after enzymolysis, and carrying out spray drying to obtain powder, wherein the compound enzyme is prepared by compounding amylase B and bromelain according to the mass ratio of 1:2; the amylase B adopts beta-amylase;
the spray drying conditions are as follows: the air inlet temperature is 160-180 ℃, and the air outlet temperature is 60-70 DEG C
Step 3, taking hawthorn, residues, lophatherum gracile, uncaria and liquorice, adding water for decoction for 2-3 times according to the mass-volume ratio of 1g to 5-10mL, merging the decoction, and concentrating to 1.20-1.30 to obtain thick paste;
and step 4, adding powder into the thick paste, uniformly mixing, and granulating to obtain the seven-ingredient stagnation-removing granules.
Example 1:
the preparation method of the seven-ingredient stagnation-removing granule is characterized by comprising the following steps of:
step 1, crushing coix seeds and rice sprouts to obtain a particle mixture with the particle size smaller than or equal to 0.77mm, adding water and amylase A into the particle mixture according to the mass ratio of the particle mixture to water to amylase A of 1:3:0.01, carrying out enzymolysis at 37 ℃ for 50min, and then filtering to obtain filtrate and residues; the amylase A is prepared by compounding beta-amylase and alpha-amylase according to a mass ratio of 2:1;
step 2, carrying out superfine grinding on periostracum Cicadae by adopting a superfine grinder to prepare superfine powder with the particle size less than or equal to 48 microns, then adding water and compound enzyme into the superfine powder according to the mass ratio of 1:2:0.01, regulating the pH value to be 6.5, carrying out enzymolysis for 55min at 53 ℃, merging reaction liquid with filtrate in the step 1 after enzymolysis, and carrying out spray drying (materials are not adhered to walls in the spraying process) to prepare powder, wherein the compound enzyme is prepared by compounding amylase B and bromelain according to the mass ratio of 1:2; the amylase B adopts beta-amylase;
the spray drying conditions are as follows: the air inlet temperature is 165 ℃, and the air outlet temperature is 65 ℃;
step 3, taking hawthorn, residues, lophatherum gracile, uncaria and liquorice, adding water for decoction according to the mass-volume ratio of 1g to 8mL (no pot burning phenomenon exists in the decoction process), decocting for 2 times, merging the decoctions, and concentrating to 1.25 to obtain thick paste;
and step 4, adding powder into the thick paste, uniformly mixing, and granulating to obtain the seven-ingredient stagnation-removing granules.
Example 2
The preparation method of the seven-ingredient stagnation-removing granule is characterized by comprising the following steps of:
step 1, crushing coix seeds and rice sprouts to obtain a particle mixture with the particle size less than or equal to 0.85mm, adding water and amylase A into the particle mixture according to the mass ratio of the particle mixture to water to amylase A of 1:2.5:0.008, carrying out enzymolysis at 35 ℃ for 60min, and then filtering to obtain filtrate and residues; the amylase A is prepared by compounding beta-amylase and alpha-amylase according to a mass ratio of 2:1;
step 2, carrying out superfine grinding on periostracum Cicadae by adopting a superfine grinder to prepare superfine powder with the particle size less than or equal to 48 microns, then adding water and compound enzyme into the superfine powder according to the mass ratio of 1:2.5:0.012, regulating the pH value to 6.2, carrying out enzymolysis for 60min at 50 ℃, merging reaction liquid with filtrate in the step 1 after enzymolysis, and carrying out spray drying (materials are not adhered to walls in the spraying process) to prepare powder, wherein the compound enzyme is prepared by compounding amylase B and bromelain according to the mass ratio of 1:2; the amylase B adopts beta-amylase;
the spray drying conditions are as follows: the air inlet temperature is 165 ℃, and the air outlet temperature is 65 ℃;
step 3, taking hawthorns, residues, lophatherum gracile, uncaria and liquorice, adding water for decoction according to the mass-volume ratio of 1g to 5ml of the feed liquid (no pot burning phenomenon exists in the decoction process), decocting for 2 times, merging the decoction, and concentrating to 1.20 to obtain thick paste;
and step 4, adding powder into the thick paste, uniformly mixing, and granulating to obtain the seven-ingredient stagnation-removing granules.
Example 3
The preparation method of the seven-ingredient stagnation-removing granule is characterized by comprising the following steps of:
step 1, crushing coix seeds and rice sprouts to obtain a particle mixture with the particle size smaller than or equal to 0.60mm, adding water and amylase A into the particle mixture according to the mass ratio of the particle mixture to water to amylase A of 1:3.5:0.012, carrying out enzymolysis at 39 ℃ for 40min, and then filtering to obtain filtrate and residues; the amylase A is prepared by compounding beta-amylase and alpha-amylase according to a mass ratio of 2:1;
step 2, carrying out superfine grinding on periostracum Cicadae by adopting a superfine grinder to prepare superfine powder with the particle size less than or equal to 48 microns, then adding water and compound enzyme into the superfine powder according to the mass ratio of the superfine powder to water to the compound enzyme of 1:1.5:0.008, regulating the pH value to 6.8, carrying out enzymolysis for 50min at 55 ℃, merging the reaction solution with the filtrate in the step 1 after enzymolysis, and carrying out spray drying (materials are not adhered to walls in the spraying process) to prepare powder, wherein the compound enzyme is prepared by compounding amylase B and bromelain according to the mass ratio of 1:2; the amylase B adopts beta-amylase;
the spray drying conditions are as follows: the air inlet temperature is 165 ℃, and the air outlet temperature is 65 ℃;
step 3, taking hawthorn, residues, lophatherum gracile, uncaria and liquorice, adding water for decoction (no pot burning phenomenon exists in the decoction process) according to the mass-to-volume ratio of 1g to 10mL, decocting for 2 times, merging the decoctions, and concentrating to 1.30 to obtain thick paste;
and step 4, adding powder into the thick paste, uniformly mixing, and granulating to obtain the seven-ingredient stagnation-removing granules.
Comparative example 1
The preparation method of the seven-ingredient stagnation-removing granule is characterized by comprising the following steps of:
step 1, crushing coix seeds and rice sprouts to obtain a particle mixture with the particle size smaller than or equal to 0.77mm, adding water and amylase A into the particle mixture according to the mass ratio of the particle mixture to water to amylase A of 1:3:0.01, carrying out enzymolysis at 37 ℃ for 50min, and then filtering to obtain filtrate and residues; the amylase A is prepared by compounding beta-amylase and alpha-amylase according to a mass ratio of 2:1;
step 2, carrying out superfine grinding on the cicada slough by adopting a superfine grinder to prepare superfine powder with the particle size less than or equal to 48 microns, then adding the superfine powder into the filtrate in the step 1, and carrying out spray drying (the wall adhesion of the material is serious in the spraying process) to prepare powder;
the spray drying conditions are as follows: the air inlet temperature is 165 ℃, and the air outlet temperature is 65 ℃;
step 3, taking hawthorn, residues, lophatherum gracile, uncaria and liquorice, adding water for decoction according to the mass-volume ratio of 1g to 8mL (no pot burning phenomenon exists in the decoction process), decocting for 2 times, merging the decoctions, and concentrating to 1.25 to obtain thick paste;
and step 4, adding powder into the thick paste, uniformly mixing, and granulating to obtain the seven-ingredient stagnation-removing granules.
Comparative example 2
The preparation method of the seven-ingredient stagnation-removing granule is characterized by comprising the following steps of:
step 1, crushing coix seeds and rice sprouts to obtain a particle mixture with the particle size smaller than or equal to 0.77mm, adding water and amylase A into the particle mixture according to the mass ratio of the particle mixture to water to amylase A of 1:3:0.01, carrying out enzymolysis at 37 ℃ for 50min, and then filtering to obtain filtrate and residues; the amylase A is prepared by compounding beta-amylase and alpha-amylase according to a mass ratio of 2:1;
step 2, carrying out superfine grinding on periostracum Cicadae by adopting a superfine grinder to prepare superfine powder with the particle size less than or equal to 48 microns, adding water and protease into the superfine powder according to the mass ratio of the superfine powder to the water to the protease of 1:2:0.01, regulating the pH value to be 6.5, carrying out enzymolysis for 55min at 53 ℃, merging the reaction solution with the filtrate in the step 1 after enzymolysis, and carrying out spray drying (the wall sticking of the material is serious in the spraying process) to prepare powder, wherein the protease adopts bromelain;
the spray drying conditions are as follows: the air inlet temperature is 165 ℃, and the air outlet temperature is 65 ℃;
step 3, taking hawthorn, residues, lophatherum gracile, uncaria and liquorice, adding water for decoction according to the mass-volume ratio of 1g to 8mL (no pot burning phenomenon exists in the decoction process), decocting for 2 times, merging the decoctions, and concentrating to 1.25 to obtain thick paste;
and step 4, adding powder into the thick paste, uniformly mixing, and granulating to obtain the seven-ingredient stagnation-removing granules.
Comparative example 3
The preparation method of the seven-ingredient stagnation-removing granule is characterized by comprising the following steps of:
step 1, crushing coix seeds and rice sprouts to obtain a particle mixture with the particle size smaller than or equal to 0.77mm, adding water and amylase A into the particle mixture according to the mass ratio of the particle mixture to water to amylase A of 1:3:0.01, carrying out enzymolysis at 37 ℃ for 50min, and then filtering to obtain filtrate and residues; the amylase A is prepared by compounding beta-amylase and alpha-amylase according to a mass ratio of 2:1;
step 2, carrying out superfine grinding on periostracum Cicadae by adopting a superfine grinder to prepare superfine powder with the particle size less than or equal to 48 microns, adding water and compound enzyme into the superfine powder according to the mass ratio of 1:2:0.01, regulating the pH value to be 6.5, carrying out enzymolysis for 55min at 53 ℃, merging reaction liquid with filtrate in the step 1 after enzymolysis, and carrying out spray drying (the wall sticking of materials is serious in the spraying process) to prepare powder, wherein the compound enzyme is prepared by compounding amylase B and bromelain according to the mass ratio of 1:2; the amylase B adopts alpha-amylase;
the spray drying conditions are as follows: the air inlet temperature is 165 ℃, and the air outlet temperature is 65 ℃;
step 3, taking hawthorn, residues, lophatherum gracile, uncaria and liquorice, adding water for decoction according to the mass-volume ratio of 1g to 8mL (no pot burning phenomenon exists in the decoction process), decocting for 2 times, merging the decoctions, and concentrating to 1.25 to obtain thick paste;
and step 4, adding powder into the thick paste, uniformly mixing, and granulating to obtain the seven-ingredient stagnation-removing granules.
Comparative example 4:
the preparation method of the seven-ingredient stagnation-removing granule is characterized by comprising the following steps of:
step 1, crushing coix seeds and rice sprouts to obtain a particle mixture with the particle size smaller than or equal to 0.77mm, adding water and amylase A into the particle mixture according to the mass ratio of the particle mixture to water to amylase A of 1:3:0.01, carrying out enzymolysis at 37 ℃ for 50min, and then filtering to obtain filtrate and residues; then spray drying the filtrate to obtain powder A (the wall sticking of the material is serious in the spraying process); the amylase A is prepared by compounding beta-amylase and alpha-amylase according to a mass ratio of 2:1;
the spray drying conditions are as follows: the air inlet temperature is 165 ℃, and the air outlet temperature is 65 ℃;
step 2, carrying out superfine grinding on periostracum Cicadae by adopting a superfine grinder to prepare superfine powder with the particle size less than or equal to 48 microns, then adding water and compound enzyme into the superfine powder according to the mass ratio of the superfine powder to the water to the compound enzyme of 1:2:0.01, regulating the pH value to be 6.5, carrying out enzymolysis for 55min at 53 ℃, merging the reaction solution with the filtrate in the step 1 after enzymolysis, and carrying out spray drying to obtain powder B, wherein the compound enzyme is prepared by compounding amylase B and bromelain according to the mass ratio of 1:2; the amylase B adopts beta-amylase;
the spray drying conditions are as follows: the air inlet temperature is 165 ℃, and the air outlet temperature is 65 ℃;
step 3, taking hawthorn, residues, lophatherum gracile, uncaria and liquorice, adding water for decoction according to the mass-volume ratio of 1g to 8mL (no pot burning phenomenon exists in the decoction process), decocting for 2 times, merging the decoctions, and concentrating to 1.25 to obtain thick paste;
and step 4, adding the powder A and the powder B into the thick paste, uniformly mixing, and granulating to obtain the seven-ingredient stagnation-eliminating granules.
Comparative example 5
The preparation method of the seven-ingredient stagnation-removing granule is characterized by comprising the following steps of:
step 1, crushing coix seeds and rice sprouts to obtain a particle mixture with the particle size smaller than or equal to 0.77mm, adding water and amylase A into the particle mixture according to the mass ratio of the particle mixture to water to amylase A of 1:3:0.01, carrying out enzymolysis at 37 ℃ for 50min, and then filtering to obtain filtrate and residues; then spray drying the filtrate to obtain powder (the wall sticking of the material is serious in the spraying process); the amylase A is prepared by compounding beta-amylase and alpha-amylase according to a mass ratio of 2:1;
the spray drying conditions are as follows: the air inlet temperature is 165 ℃, and the air outlet temperature is 65 ℃;
step 2, taking periostracum cicadae, hawthorn, residues, lophatherum gracile, uncaria and liquorice, decocting in water (no burnt pot phenomenon exists in the decoction process, but the periostracum cicadae floats above the liquid level) for 2 times according to the mass-to-volume ratio of 1g to 8mL, mixing the decoctions, and concentrating to 1.25 to obtain thick paste;
and step 3, adding powder into the thick paste, uniformly mixing, and granulating to obtain the seven-ingredient stagnation-removing granules.
Comparative example 6
The preparation method of the seven-ingredient stagnation-removing granule is characterized by comprising the following steps of:
step 1, crushing coix seeds and rice sprouts to obtain a particle mixture with the particle size smaller than or equal to 0.77mm, adding water and amylase A into the particle mixture according to the mass ratio of the particle mixture to water to amylase A of 1:3:0.01, carrying out enzymolysis at 37 ℃ for 50min, and then filtering to obtain filtrate and residues; the amylase A is prepared from alpha-amylase;
step 2, carrying out superfine grinding on periostracum Cicadae by adopting a superfine grinder to prepare superfine powder with the particle size less than or equal to 48 microns, then adding water and compound enzyme into the superfine powder according to the mass ratio of 1:2:0.01, regulating the pH value to be 6.5, carrying out enzymolysis for 55min at 53 ℃, merging reaction liquid with filtrate in the step 1 after enzymolysis, and carrying out spray drying (materials are not adhered to walls in the spraying process) to prepare powder, wherein the compound enzyme is prepared by compounding amylase B and bromelain according to the mass ratio of 1:2; the amylase B adopts beta-amylase;
the spray drying conditions are as follows:
step 3, taking hawthorn, residues, lophatherum gracile, uncaria and liquorice, adding water for decoction according to the mass-volume ratio of 1g to 8mL (no pot burning phenomenon exists in the decoction process), decocting for 2 times, merging the decoctions, and concentrating to 1.25 to obtain thick paste;
and step 4, adding powder into the thick paste, uniformly mixing, and granulating to obtain the seven-ingredient stagnation-removing granules.
Comparative example 7
The preparation method of the seven-ingredient stagnation-removing granule is characterized by comprising the following steps of:
step 1, taking coix seed, rice sprout, cicada slough, hawthorn, residues, lophatherum gracile, uncaria and liquorice according to the mass-volume ratio of 1g to 8mL, adding water for decoction (the phenomenon of pot burning occurs in the decoction process, and the cicada slough floats above the liquid level), decocting for 2 times, merging the decoction, and concentrating to 1.25 to obtain thick paste;
and step 2, granulating the thick paste to obtain the seven-ingredient stagnation-eliminating granules.
Effect example: clinical trial
Calves cultured in 130 calves within forty days in one cattle farm in northeast are difficult to control, and the clinical symptoms are as follows: calves can remove yellow, white and thin feces, and have the symptoms of limp and weak, depression, slow eye, standing of the spinal arch, blushing tongue fur, running water, and slight cooling of ears and nose. The yellow color is discharged, the feces are foul, and the water is slightly dehydrated. Oral medicine and injection treatment are adopted, so that the treatment is improved, but many of the treatment is bad, and the treatment is gradually changed into red loose stool, bloody stool and even death;
the 120 calves in the calf farm are randomly divided into 6 groups, each group is 20, the administration treatment is carried out, blank control is arranged at the same time, the treatment effect of each group is observed, and the result is shown in table 1;
grouping condition:
test group: 50 g of the seven-ingredient stagnation eliminating granule and the new enterotoxin remover prepared in the embodiment 1 of the invention are taken by 20 g of the granule for irrigation once a day for three days, and then the probiotic is supplemented to regulate intestines and stomach. Meanwhile, the cold-proof and warm-keeping environment is clean and the breasts are disinfected.
Control group: 50 g of the seven-ingredient stagnation-removing granule and the new enterotoxin remover prepared in comparative example 4 are taken by 20 g of the granule, once a day for three days, and then the granule is supplemented with probiotics to condition intestines and stomach. Meanwhile, the cold-proof and warm-keeping environment is clean and the breasts are disinfected.
Control two groups: 50 g of the seven-ingredient stagnation-removing granule and the new enterotoxin remover prepared in the comparative example 5 are taken by 20 g of the liquid medicine, and the liquid medicine is used for three days once a day, and then the intestines and stomach are conditioned by supplementing probiotics. Meanwhile, the cold-proof and warm-keeping environment is clean and the breasts are disinfected.
Control three groups: 50 g of the seven-ingredient stagnation-removing granule and the new enterotoxin remover prepared in the comparative example 6 are taken by 20 g of the liquid medicine, and the liquid medicine is used for three days once a day, and then the probiotic is supplemented to condition intestines and stomach. Meanwhile, the cold-proof and warm-keeping environment is clean and the breasts are disinfected.
Control four groups: 50 g of the seven-ingredient stagnation-removing granule and the new enterotoxin remover prepared in the comparative example 7 are taken by 20 g of the liquid medicine, and the liquid medicine is used for three days once a day, and then the intestines and stomach are conditioned by supplementing probiotics. Meanwhile, the cold-proof and warm-keeping environment is clean and the breasts are disinfected.
Blank control group: 50 g of placebo and 20 g of new enterotoxin remover are administered by pouring once a day for three days, and then the probiotics are supplemented to regulate intestines and stomach. Meanwhile, the cold-proof and warm-keeping environment is clean and the breasts are disinfected.
Drug effect evaluation criteria:
obvious improvement: the diarrhea frequency is reduced, the bow back is not obvious, and the patient has little appetite;
and (3) curing: fecal forming, normal spirit, random walking and recovery of food intake;
invalidation: obvious diarrhea, depression, limp and weak, and reluctant to walk;
TABLE 1
The above described embodiments are only preferred examples of the invention and are not exhaustive of the possible implementations of the invention. Any obvious modifications thereof, which would be apparent to those skilled in the art without departing from the principles and spirit of the present invention, should be considered to be included within the scope of the appended claims.
Claims (9)
1. The preparation method of the seven-ingredient stagnation-removing granule is characterized by comprising the following steps of:
step 1, crushing coix seeds and rice sprouts to obtain a particle mixture, adding water and amylase A into the particle mixture for enzymolysis, and filtering to obtain filtrate and residues;
step 2, carrying out superfine grinding on periostracum cicadae by adopting a superfine grinder to prepare superfine powder, then adding water and compound enzyme into the superfine powder for enzymolysis, combining reaction liquid with the filtrate in the step 1 after enzymolysis, and carrying out spray drying to obtain powder, wherein the compound enzyme comprises amylase B and protease;
step 3, decocting hawthorn, lophatherum gracile, uncaria, liquorice and residues obtained in the step 1 in water for 2-3 times, mixing decoctions, and concentrating to 1.20-1.30 to obtain thick paste;
and step 4, adding the powder obtained in the step 2 into the thick paste, uniformly mixing, and granulating to obtain the seven-ingredient stagnation-eliminating granules.
2. The method for preparing the seven-ingredient digestion-promoting granules according to claim 1, wherein,
the particle size of the particle mixture in the step 1 is less than or equal to 0.60mm-0.85mm.
3. The method for preparing the seven-ingredient digestion-promoting granules according to claim 1, wherein,
in the step 1, the mass ratio of the particles to the water to the amylase A is 1 (2.5-3.5) (0.008-0.012); the amylase A comprises beta-amylase, and the enzymolysis condition is that the enzymolysis is carried out for 40-60min at 35-40 ℃.
4. A method for preparing a seven ingredient digestion-promoting granule according to claim 3, wherein,
the amylase A also comprises alpha-amylase, and the mass ratio of the beta-amylase to the alpha-amylase is 2:1.
5. The method for preparing the seven-ingredient digestion-promoting granules according to claim 1, wherein,
in the step 2, the particle size of the superfine powder is less than or equal to 48 micrometers.
6. The method for preparing the seven-ingredient digestion-promoting granules according to claim 1, wherein,
the mass ratio of the superfine powder to the water to the complex enzyme is 1 (1.5-2.5) (0.008-0.012); the complex enzyme is prepared by compounding amylase B and bromelain according to a mass ratio of 1:2; the enzymolysis conditions are as follows: enzymolysis is carried out for 50-60min at 50-55deg.C and pH of 6.2-7.2.
7. The method for preparing the seven-ingredient digestion-promoting granules according to claim 6, wherein,
the amylase B adopts beta-amylase.
8. The method for preparing the seven-ingredient digestion-promoting granules according to claim 1, wherein,
in step 2, the spray drying conditions are as follows: the air inlet temperature is 160-180 ℃ and the air outlet temperature is 60-70 ℃.
9. The method for preparing the seven-ingredient digestion-promoting granules according to claim 1, wherein,
in the step 3, the hawthorn, the residue, the lophatherum gracile, the uncaria and the liquorice are added into water according to the mass-volume ratio of 1g to 5-10 mL.
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101143019A (en) * | 2007-10-19 | 2008-03-19 | 海通食品集团股份有限公司 | Method for preparing instant composite solid fruit and vegetable beverage dried by control sticking wall-prevention spray-drying |
| CN102441286A (en) * | 2010-09-30 | 2012-05-09 | 上海张江中药现代制剂技术工程研究中心 | Method for improving melt wall sticking during spray drying of traditional Chinese medicine or food raw material |
| CN103142888A (en) * | 2013-03-21 | 2013-06-12 | 青岛正大海尔制药有限公司 | Children Qixing drink tea soft capsule preparation |
| CN104055801A (en) * | 2013-03-23 | 2014-09-24 | 河北以岭医药研究院有限公司 | Cicada slough protease enzymolytic product and application thereof |
| CN106581685A (en) * | 2016-12-13 | 2017-04-26 | 广州市香雪制药股份有限公司 | Method and auxiliary composition for improving wall adhesion of traditional Chinese medicine extract in spray drying |
| CN110448656A (en) * | 2019-09-04 | 2019-11-15 | 河北地邦动物保健科技有限公司 | A kind of formula and preparation method thereof of seven-star tea granule |
-
2023
- 2023-05-12 CN CN202310536597.0A patent/CN116473926A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101143019A (en) * | 2007-10-19 | 2008-03-19 | 海通食品集团股份有限公司 | Method for preparing instant composite solid fruit and vegetable beverage dried by control sticking wall-prevention spray-drying |
| CN102441286A (en) * | 2010-09-30 | 2012-05-09 | 上海张江中药现代制剂技术工程研究中心 | Method for improving melt wall sticking during spray drying of traditional Chinese medicine or food raw material |
| CN103142888A (en) * | 2013-03-21 | 2013-06-12 | 青岛正大海尔制药有限公司 | Children Qixing drink tea soft capsule preparation |
| CN104055801A (en) * | 2013-03-23 | 2014-09-24 | 河北以岭医药研究院有限公司 | Cicada slough protease enzymolytic product and application thereof |
| CN106581685A (en) * | 2016-12-13 | 2017-04-26 | 广州市香雪制药股份有限公司 | Method and auxiliary composition for improving wall adhesion of traditional Chinese medicine extract in spray drying |
| CN110448656A (en) * | 2019-09-04 | 2019-11-15 | 河北地邦动物保健科技有限公司 | A kind of formula and preparation method thereof of seven-star tea granule |
Non-Patent Citations (4)
| Title |
|---|
| 刘梅森: "响应面法优化双酶水解技术生产婴幼儿配方米粉工艺", 食品科学, vol. 35, no. 22, 25 November 2014 (2014-11-25), pages 63 - 67 * |
| 朴香兰: "民族药物提取分离新技术", 30 November 2011, 中央民族大学出版社, pages: 39 - 40 * |
| 肖树雄: "中成药标准提高研究与探索", 31 March 2010, 羊城晚报出版社, pages: 68 - 69 * |
| 艾自明: "蝉衣多糖的提取及理化性质测定", 云南中医中药杂志, vol. 31, no. 4, 20 January 2010 (2010-01-20), pages 56 - 58 * |
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