CN110338266A - One broad sow Chinese medicine complex peptides feed addictive and preparation method thereof - Google Patents
One broad sow Chinese medicine complex peptides feed addictive and preparation method thereof Download PDFInfo
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- CN110338266A CN110338266A CN201910791148.4A CN201910791148A CN110338266A CN 110338266 A CN110338266 A CN 110338266A CN 201910791148 A CN201910791148 A CN 201910791148A CN 110338266 A CN110338266 A CN 110338266A
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
- A23K10/14—Pretreatment of feeding-stuffs with enzymes
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/142—Amino acids; Derivatives thereof
- A23K20/147—Polymeric derivatives, e.g. peptides or proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/189—Enzymes
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/288—Taraxacum (dandelion)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/36—Caryophyllaceae (Pink family), e.g. babysbreath or soapwort
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/46—Eucommiaceae (Eucommia family), e.g. hardy rubber tree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/734—Crataegus (hawthorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
- A61K36/8998—Hordeum (barley)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/01—Hydrolysed proteins; Derivatives thereof
- A61K38/011—Hydrolysed proteins; Derivatives thereof from plants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
Abstract
The present invention relates to veterinary drug technical fields more particularly to a broad sow Chinese medicine complex peptides feed addictive and preparation method thereof.It include soybean peptide, Radix Astragali zymolyte, Radix Angelicae Sinensis zymolyte, Rhizoma Chuanxiong zymolyte, Cortex Eucommiae zymolyte, seed of cowherb zymolyte, hawthorn zymolyte, dandelion zymolyte, coloured malt zymolyte, luffa zymolyte, peppermint zymolyte and rhizoma zingiberis zymolyte in the feed addictive.Noxious material or anaphylactogen are free of in the above components, it is highly-safe, it is good for the eating effect of sow, sow immunity and feed conversion rate can be significantly improved, keeps the piglet survival ratio of gestational period sows farrowing high.Antibiotic can be without the use of in the breeding process using the additive, the problem of so as to avoid drug resistance and medicament residue.
Description
Technical field
The present invention relates to veterinary drug technical field more particularly to a broad sow Chinese medicine complex peptides feed addictive and its preparation sides
Method.
Background technique
It is grown in industry in pig raising, female swine rearing breeds swinery most important.The health of the gestational period and sow in lactation
Directly the health and survival rate of piglet are decide, to determine swinery growth rate and aquaculture cost.Due to non-infectious or
The communicable cause of disease can cause sow breeding difficulty, such as miscarry, output stillborn foetus, the mummification of fetus, monster, weak son or postpartum milk
Water is insufficient, milk water quality is bad.Therefore, raiser can generally prevent the generation of above situation using feed addictive.Sow
Feed addictive includes antibiotic, microelement, microorganism, Chinese herbal medicine etc..The use of antibiotic can destroy micro- in natural environment
The interbiotic ecological balance, and can be remained in food and seriously affect human health；Microelement dosage is not easy control, very few
The effect of extra-nutrition is then not achieved, is excessively then possible to cause to be poisoned.Therefore microorganism or Chinese herbal medicine sow feed additive by
Gradually become mainstream.Additive for microbe feedstuff includes enzyme preparation or probiotics etc., to intestinal beneficial, but to the resistant function of virus
Weaker and action is slow, needs to be further increased；On the one hand Chinese herbal medicine or its extract generally require larger dosage, thereby increases and it is possible to contain
On the other hand the insecurity factors such as noxious material or anaphylactogen also will increase sow kidney burden, reduce feed conversion rate.
Summary of the invention
It is for existing sow Chinese herbal feed additive ineffective, there are insecurity factor, reduce feed conversion rate
Problem, the present invention provide a broad sow Chinese medicine complex peptides feed addictive.
And the present invention also provides the preparation methods of a broad sow Chinese medicine complex peptides feed addictive.
To achieve the above object of the invention, the embodiment of the present invention adopts the technical scheme that
One broad sow Chinese medicine complex peptides feed addictive, including following components in percentage by weight: soybean peptide 62.4~
73.4%, Radix Astragali zymolyte 4.2~5.2%, Radix Angelicae Sinensis zymolyte 4.2~5.2%, Rhizoma Chuanxiong zymolyte 4.0~5.0%, Cortex Eucommiae enzyme
Solve object 3.6~4.6%, seed of cowherb zymolyte 2.4~3.4%, hawthorn zymolyte 2.0~3.0%, dandelion zymolyte 1.5
~2.5%, coloured malt zymolyte 1.5~2.5%, luffa zymolyte 1.2~2.2%, 1.0~2.0% and of peppermint zymolyte
Rhizoma zingiberis zymolyte 1.0~2.0%, the soybean peptide and each zymolyte are by corresponding raw material through cellulase, lipase, starch
Enzyme and neutral proteinase obtain after being digested.
Wherein soybean peptide is preferably digested using Soybean Meal as raw material and is obtained.
Radix Astragali tonifying Qi, hidroschesis, inducing diuresis to remove edema, apocenosis；Radix Angelicae Sinensis relax bowel and defecation, activating microcirculation and removing stasis medicinal；Cortex Eucommiae diuresis, anti-inflammatory, rush disappear
Change；Seed of cowherb blood circulation, lower cream detumescence, inducing diuresis for treating strangurtia；Hawthorn digesting stomach invigorating activates blood circulation and disperses blood clots, convergence and dysentery；Luffa is opened
Stomach invigorating the spleen promotes the production of body fluid to quench thirst, relieving restlessness of relieving summer heat.This Six-element Chinese medicine shares after digesting, to sow have kidney tonifying, fill blood, lower cream disappears
It swells, active effect of invigorating blood circulation.
Rhizoma Chuanxiong promoting blood circulation, promote breath and open depression, wind-expelling pain-stopping；Dandelion is clearing heat and detoxicating, dispersing swelling and dissipating binds, inducing diuresis for treating strangurtia；Fry wheat
Bud promoting the circulation of qi helps digestion, spleen benefiting and stimulating the appetite, moves back newborn dissipate-swelling；Rhizoma zingiberis warming spleen and stomach for dispelling cold, recover Yang and smooth venation, eliminating dampness dissolving phlegm；It is peppermint sweating and heat resolving, soothing the liver
Qi-regulating.This traditional Chinese medicine of the five flavours shares after digesting, and has the function of improving sow postpartum spleen deficiency, qi-blood deficiency.
Soybean peptide has the function of anti-bacteria and anti-virus, health care digestive system, and can be as carrier each taste Chinese medicine zymolyte
In active material and vitamin and mine quality be transported to and intracellular quickly participate in life movement.
The sow Chinese medicine complex peptides feed addictive pair that the above components are composed in the percent ranges of restriction
It is good in the eating effect of sow, sow immunity and feed conversion rate can be significantly improved, so that the general level of the health of sow is improved,
Keep the piglet survival ratio of gestational period sows farrowing high, keeps sow in lactation milk sufficient.In the additive without noxious material or
Anaphylactogen, it is highly-safe.Rationally due to ingredient and proportion, additive amount is small, and feed per ton is only needed using 300~500g
Reach good result, and antibiotic can be without the use of in the breeding process using the additive, so as to avoid drug resistance with
And the problem of medicament residue.Other than sow, which can also be used in the female mammals such as ewe, mare.
Preferably, which includes the component of following parts by weight proportion: including following components in percentage by weight: big
Beans peptide 65.4~70.4%, Radix Astragali zymolyte 4.5~4.9%, Radix Angelicae Sinensis zymolyte 4.5~4.9%, Rhizoma Chuanxiong zymolyte 4.3~
4.7%, Cortex Eucommiae zymolyte 3.8~4.3%, seed of cowherb zymolyte 2.6~3.2%, hawthorn zymolyte 2.2~2.8%, Pu Gong
English zymolyte 1.8~2.2%, coloured malt zymolyte 1.8~2.2%, luffa zymolyte 1.5~2.0%, peppermint zymolyte
1.3~1.7% and rhizoma zingiberis zymolyte 1.3~1.7%.
Preferably, raw material includes the component of following parts by weight proportion: including following components in percentage by weight: soybean peptide
67.9%, Radix Astragali zymolyte 4.7%, Radix Angelicae Sinensis zymolyte 4.7%, Rhizoma Chuanxiong zymolyte 4.5%, Cortex Eucommiae zymolyte 4.1%, Wang Buliu
Row zymolyte 2.9%, hawthorn zymolyte 2.5%, dandelion zymolyte 2.0%, coloured malt zymolyte 2.0%, luffa enzymatic hydrolysis
Object 1.7%, peppermint zymolyte 1.5% and rhizoma zingiberis zymolyte 1.5%.
And the embodiment of the invention also provides the preparation methods of a broad sow Chinese medicine complex peptides feed addictive, specifically
The following steps are included:
Step a, by the raw soybeans dregs of rice, Radix Astragali, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Cortex Eucommiae, the seed of cowherb, hawthorn, dandelion, coloured malt, silk
Melon network, peppermint and rhizoma zingiberis are respectively placed in 7~8h of decoction in purified water, obtain decocting medical fluid accordingly；
Step b, into each decoction medical fluid obtained by step a respectively with cellulase, lipase, amylase and neutral egg
White enzyme is digested, and corresponding enzymolysis liquid is obtained；
Step c, each enzymolysis liquid obtained by step b is separated by solid-liquid separation respectively, gained liquid is purified respectively, is dense
Contracting, drying, obtain soybean peptide and each zymolyte, weigh the soybean peptide and each enzymatic hydrolysis by said components weight percent
Object, be uniformly mixed to get.
Preparation method provided by the present invention first decocts Soybean Meal and Chinese medicine, can excite the medicine of each taste Chinese medicine
Property, and soften each raw material, being conducive to the leaching of effective component and vitamin, minerals, (decocting medical fluid obtained by step a includes
Raw material in decoction liquor and decoction liquor).Using cellulase, lipase, four kinds of enzymes of amylase and neutral proteinase enzyme
Solution decomposes fiber by cellulase and by lipase decomposes the fat constituent in each raw material, allows protein component from original
Separated in material, then by neutral proteinase to the protein separated digested to obtain molecular weight polymers, polypeptide with
And other compositions, to improve the recovery rate from zymolyte, that is, extracted from the Soybean Meal and Chinese medicine of Unit Weight more
Soybean peptide and Chinese medicine zymolyte；Meanwhile lipase reduces the fat constituent in enzymolysis liquid, amylase can starch-splitting at
Point, the two collocation uses, and makes the reduction of enzymolysis liquid viscosity, it is easier to filter, to improve more soybean peptides and Chinese medicine enzymatic hydrolysis
The yield of object, that is, the resulting soybean peptide of step c and each taste Chinese medicine zymolyte account for the resulting soybean peptide of step b and Chinese medicine zymolyte
Ratio.
Polysaccharide conversion is oligosaccharide at micromolecule polypeptide by the preparation method by the protein component enzymatic hydrolysis in raw material, and
The toxicity and anaphylactogen that can be degraded in Chinese medicine, so that product be made to be easier to be absorbed and utilized and safe and non-toxic.Soybean Meal through decoct,
After enzymatic hydrolysis, it can decompose the soybean peptide (soybean oligopeptide) and soyabean oligosaccharides of small molecule, wherein soybean peptide can play excellent
Active material and microorganism, minerals phase chelating in different chelation, with Chinese medicine zymolyte form the chela for being easier to absorb
It closes object and is quickly absorbed by sow, be rapidly achieved enhancing nutrition, improve immunity, the improvement gestational period and nursing period health status
Effect.
For polypeptide in this method preparation gained zymolyte based on small-molecular-weight polypeptide, the molecular weight of 96% or more polypeptide is small
In 1000 dalton, is conducive to sow and quickly absorbs.It is soluble easily in water that the preparation method prepares products obtained therefrom, can be added directly into general
In logical feed or drinking water.
Preferably, the weight of water described in step a be the Soybean Meal, Radix Astragali, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Cortex Eucommiae, the seed of cowherb,
7~8 times of the respective weight of hawthorn, dandelion, coloured malt, luffa, peppermint and rhizoma zingiberis.Enough waters can make in each raw material
Effective component leached as much as possible during decoction and soften raw material enough, be conducive to fill in stepb
Divide enzymatic hydrolysis.It is unlikely to simultaneously with water excess, increase subsequent concentration time, reduction production efficiency.
Preferably, the temperature decocted in step a is 90~95 DEG C.The temperature can promote the leaching of effective component in raw material,
The too low then decreased effectiveness of temperature, temperature is excessively high, can destroy part effective component.
Preferably, cellulase described in step b is Li Shi trichoderma cellulase, and dosage is each raw material described in step a
The 1.5~2% of original weight amount；For the lipase by Rhizopus oryzae lipase, dosage is 1.5 of each raw material original weight amount described in step a
~2%；The amylase is aspergillus niger amylase, and dosage is 1~1.5% of each raw material original weight amount described in step a；In described
Property protease be aspergillus oryzae protease, dosage be step a described in each raw material original weight amount 1~1.5%.Li Shi trichoderma cellulase
Enzymatic activity is higher, the β in fiber-Isosorbide-5-Nitrae glucoside bond hydrolysis can be generated soluble low polymer and D- grape
Sugar；Rhizopus oryzae lipase has 1,3 position the specificity of height, and conversion ratio with higher and stability, can be effective
Fat in the decomposing soybean dregs of rice and traditional Chinese medicine ingredients；Acidproof alpha-amylase can be obtained in fermentation of Aspergillus niger, can act in raw material
Starch component generates the reduced sugars such as maltose, maltotriose, dextrin, increases product sweet taste, moreover it is possible to viscosity is reduced, in favor of enzyme
Solution reaction sufficiently efficiently carries out；Aspergillus oryzae protease has wider pH tolerance range and very strong protein breakdown ability,
Can high temperature resistant, stability is good, and protein component can be made sufficiently to be decomposed into polypeptide, improves polypeptide.
Preferably, the condition digested in step b are as follows: then 3.0~4.0h of stirring enzymatic hydrolysis under the conditions of 56~58 DEG C heats up
To 90~95 DEG C, 10~15min enzyme deactivation is kept.Optimization of the operating method through excess temperature, enzymolysis time keeps above-mentioned four kinds of enzymes total
It is improved with the time shortening of enzymatic hydrolysis, efficiency, had both hydrolyzed the substance that starch and indigestibility in raw material absorb, and in turn ensured activity
Substance is not destroyed.
Preferably, the operation of separation of solid and liquid described in step c is to filter after being centrifuged, and centrifugal rotational speed is 3400~3800r/
Min, to remove the insoluble matter in enzymolysis liquid and be difficult to the macromolecular absorbed.As preferred embodiment, which can
Using decanter centrifuge, it is more suitable for the separation of solid and liquid of thick liquid.
Purifying described in step c carries out in three-phase centrifuge, and centrifugal rotational speed is 17000~19000r/min, with removal
Insoluble matter and macromolecular substances in enzymolysis liquid make the polypeptide in product as much as possible with the polypeptide of 1000 dalton of molecular weight <
Based on.
Preferably, dry for spray drying described in step c.
Specific embodiment
In order to make the objectives, technical solutions, and advantages of the present invention clearer, below in conjunction with specific embodiment, to this
Invention is further elaborated.It should be appreciated that specific embodiment described herein is used only for explaining the present invention, not
For limiting the present invention.
Embodiment 1
Present embodiments provide a broad sow Chinese medicine complex peptides feed addictive, including following components: soybean peptide 67.4g,
Radix Astragali zymolyte 4.7g, Radix Angelicae Sinensis zymolyte 4.7g, Rhizoma Chuanxiong zymolyte 4.5g, Cortex Eucommiae zymolyte 4.1g, seed of cowherb zymolyte
2.9g, hawthorn zymolyte 2.5g, dandelion zymolyte 2.0g, coloured malt zymolyte 2.0g, luffa zymolyte 1.7g, peppermint enzyme
Solve object 1.5g and rhizoma zingiberis zymolyte 1.5g.Preparation method specifically includes the following steps:
Step a, Soybean Meal, Radix Astragali, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Cortex Eucommiae, the seed of cowherb, hawthorn, dandelion, coloured malt, sponge gourd are chosen
Network, peppermint and each 1kg of rhizoma zingiberis, are separately added into 7.5kg purified water and stir evenly, and decoct 7.5h under the conditions of 92 DEG C, obtain corresponding
Decoction medical fluid (including the raw material in decoction liquor and decoction liquor)；
Step b, each decoction medical fluid obtained by step a is cooled to 57 DEG C respectively, addition 17.5g Li Shi trichoderma fiber
Plain enzyme, 17.5g Rhizopus oryzae lipase, 12.5g aspergillus niger amylase and 12.5g aspergillus oryzae protease are digested in 57 DEG C of stirrings
3.5h after the completion of enzymatic hydrolysis, is warming up to 92 DEG C, keeps 12min enzyme deactivation, obtain corresponding enzymolysis liquid；
Step c, following operation is respectively adopted in each enzymolysis liquid resulting for step b: with decanter centrifuge in 3600r/min
Revolving speed under be centrifuged, be filtered to remove solid content, then centrifugal filtration is purified under the revolving speed of 18000r/min with three-phase centrifuge, filter
Liquid is further concentrated with dual-effect concentrator, by concentrate 40~50 DEG C at a temperature of be spray-dried, obtain soybean peptide and described
Each zymolyte.Gained soybean peptide and each zymolyte are weighed by above-mentioned weight percent, is uniformly mixed to get compound to sow Chinese medicine
Peptide feed addictive.
The usage and dosage of products obtained therefrom are as follows: daily addition, feed usage amount per ton are 500g.
Embodiment 2
Present embodiments provide a broad sow Chinese medicine complex peptides feed addictive, including following components: soybean peptide 73.4g,
Radix Astragali zymolyte 4.2g, Radix Angelicae Sinensis zymolyte 4.2g, Rhizoma Chuanxiong zymolyte 4.0g, Cortex Eucommiae zymolyte 3.6g, seed of cowherb zymolyte
2.4g, hawthorn zymolyte 2.0g, dandelion zymolyte 1.5g, coloured malt zymolyte 1.5g, luffa zymolyte 1.2g, peppermint enzyme
Solve object 1.0g and rhizoma zingiberis zymolyte 1.0g.Preparation method specifically includes the following steps:
Step a, Soybean Meal, Radix Astragali, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Cortex Eucommiae, the seed of cowherb, hawthorn, dandelion, coloured malt, sponge gourd are chosen
Network, peppermint and each 1kg of rhizoma zingiberis, are separately added into 7kg purified water and stir evenly, and decoct 7h under the conditions of 90 DEG C, are decocted accordingly
Decoct medicinal herbs liquid (including the raw material in decoction liquor and decoction liquor)；
Step b, each decoction liquor obtained by step a is cooled to 56 DEG C respectively, addition 15g Li Shi trichoderma cellulase
Enzyme, 15g Rhizopus oryzae lipase, 10g aspergillus niger amylase and 10g aspergillus oryzae protease digest 3.0h in 56 DEG C of stirrings, have digested
Cheng Hou is warming up to 90 DEG C, keeps 10min enzyme deactivation, obtains corresponding enzymolysis liquid；
Step c, following operation is respectively adopted in each enzymolysis liquid resulting for step b: with decanter centrifuge in 3400r/min
Revolving speed under be centrifuged, be filtered to remove solid content, then centrifugal filtration is purified under the revolving speed of 17000r/min with three-phase centrifuge, filter
Liquid is further concentrated with dual-effect concentrator, by concentrate 40~50 DEG C at a temperature of be spray-dried, obtain soybean peptide and described
Each zymolyte.Gained soybean peptide and each zymolyte are weighed by above-mentioned weight percent, is uniformly mixed to get compound to sow Chinese medicine
Peptide feed addictive.
The usage and dosage of products obtained therefrom are as follows: daily addition, feed usage amount per ton are 300g.
Embodiment 3
Present embodiments provide a broad sow Chinese medicine complex peptides feed addictive, including following components: soybean peptide 62.4g,
Radix Astragali zymolyte 5.2g, Radix Angelicae Sinensis zymolyte 5.2g, Rhizoma Chuanxiong zymolyte 5.0g, Cortex Eucommiae zymolyte 4.6g, seed of cowherb zymolyte
3.4g, hawthorn zymolyte 3.0g, dandelion zymolyte 2.5g, coloured malt zymolyte 2.5g, luffa zymolyte 2.2g, peppermint enzyme
Solve object 2.0g and rhizoma zingiberis zymolyte 2.0g.Preparation method specifically includes the following steps:
Step a, Soybean Meal, Radix Astragali, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Cortex Eucommiae, the seed of cowherb, hawthorn, dandelion, coloured malt, sponge gourd are chosen
Network, peppermint and each 1kg of rhizoma zingiberis, are separately added into 8.0kg purified water and stir evenly, and decoct 8.0h under the conditions of 95 DEG C, obtain corresponding
Decoction medical fluid (including the raw material in decoction liquor and decoction liquor)；
Step b, each decoction liquor obtained by step a is cooled to 58 DEG C respectively, addition 20g Li Shi trichoderma cellulase
Enzyme, 20g Rhizopus oryzae lipase, 15g aspergillus niger amylase and 15g aspergillus oryzae protease digest 4.0h in 58 DEG C of stirrings, have digested
Cheng Hou is warming up to 95 DEG C, keeps 15min enzyme deactivation, obtains corresponding enzymolysis liquid；
Step c, following operation is respectively adopted in each enzymolysis liquid resulting for step b: with decanter centrifuge in 3800r/min
Revolving speed under be centrifuged, be filtered to remove solid content, then centrifugal filtration is purified under the revolving speed of 19000r/min with three-phase centrifuge, filter
Liquid is further concentrated with dual-effect concentrator, by concentrate 40~50 DEG C at a temperature of be spray-dried, obtain soybean peptide and described
Each zymolyte.Gained soybean peptide and each zymolyte are weighed by above-mentioned weight percent, is uniformly mixed to get compound to sow Chinese medicine
Peptide feed addictive.
The usage and dosage of products obtained therefrom are as follows: daily addition, feed usage amount per ton are 1000g.
Embodiment 4
Present embodiments provide a broad sow Chinese medicine complex peptides feed addictive, including following components: soybean peptide 65.4g,
Radix Astragali zymolyte 4.9g, Radix Angelicae Sinensis zymolyte 4.9g, Rhizoma Chuanxiong zymolyte 4.7g, Cortex Eucommiae zymolyte 4.3g, seed of cowherb zymolyte
3.2g, hawthorn zymolyte 2.8g, dandelion zymolyte 2.2g, coloured malt zymolyte 2.2g, luffa zymolyte 2.0g, peppermint enzyme
Solve object 1.7g and rhizoma zingiberis zymolyte 1.7g.Preparation method specifically includes the following steps:
Step a, Soybean Meal, Radix Astragali, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Cortex Eucommiae, the seed of cowherb, hawthorn, dandelion, coloured malt, sponge gourd are chosen
Network, peppermint and each 1kg of rhizoma zingiberis, are separately added into 8.0kg purified water and stir evenly, and decoct 7.0h under the conditions of 95 DEG C, obtain corresponding
Decoction medical fluid (including the raw material in decoction liquor and decoction liquor)；
Step b, each decoction liquor obtained by step a is cooled to 58 DEG C respectively, addition 15g Li Shi trichoderma cellulase
Enzyme, 15g Rhizopus oryzae lipase, 10g aspergillus niger amylase and 10g aspergillus oryzae protease digest 4.0h in 58 DEG C of stirrings, have digested
Cheng Hou is warming up to 90 DEG C, keeps 15min enzyme deactivation, obtains corresponding enzymolysis liquid；
Step c, following operation is respectively adopted in each enzymolysis liquid resulting for step b: with decanter centrifuge in 3800r/min
Revolving speed under be centrifuged, be filtered to remove solid content, then centrifugal filtration is purified under the revolving speed of 17000r/min with three-phase centrifuge, filter
Liquid is further concentrated with dual-effect concentrator, by concentrate 40~50 DEG C at a temperature of be spray-dried, obtain soybean peptide and described
Each zymolyte.Gained soybean peptide and each zymolyte are weighed by above-mentioned weight percent, is uniformly mixed to get compound to sow Chinese medicine
Peptide feed addictive.
The usage and dosage of products obtained therefrom are as follows: daily addition, feed usage amount per ton are 300g.
Embodiment 5
Present embodiments provide a broad sow Chinese medicine complex peptides feed addictive, including following components: soybean peptide 70.4g,
Radix Astragali zymolyte 4.5g, Radix Angelicae Sinensis zymolyte 4.5g, Rhizoma Chuanxiong zymolyte 4.3g, Cortex Eucommiae zymolyte 3.8g, seed of cowherb zymolyte
2.6g, hawthorn zymolyte 2.2g, dandelion zymolyte 1.8g, coloured malt zymolyte 1.8g, luffa zymolyte 1.5g, peppermint enzyme
Solve object 1.3g and rhizoma zingiberis zymolyte 1.3g.Preparation method specifically includes the following steps:
Step a, Soybean Meal, Radix Astragali, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Cortex Eucommiae, the seed of cowherb, hawthorn, dandelion, coloured malt, sponge gourd are chosen
Network, peppermint and each 1kg of rhizoma zingiberis, are separately added into 7.0kg purified water and stir evenly, and decoct 8.0h under the conditions of 95 DEG C, obtain corresponding
Decoction medical fluid (including the raw material in decoction liquor and decoction liquor)；
Step b, each decoction liquor obtained by step a is cooled to 56 DEG C respectively, addition 20g Li Shi trichoderma cellulase
Enzyme, 20g Rhizopus oryzae lipase, 15g aspergillus niger amylase and 15g aspergillus oryzae protease digest 3.0h in 56 DEG C of stirrings, have digested
Cheng Hou is warming up to 95 DEG C, keeps 10min enzyme deactivation, obtains corresponding enzymolysis liquid；
Step c, following operation is respectively adopted in each enzymolysis liquid resulting for step b: with decanter centrifuge in 3400r/min
Revolving speed under be centrifuged, be filtered to remove solid content, then centrifugal filtration is purified under the revolving speed of 19000r/min with three-phase centrifuge, filter
Liquid is further concentrated with dual-effect concentrator, by concentrate 40~50 DEG C at a temperature of be spray-dried, obtain soybean peptide and described
Each zymolyte.Gained soybean peptide and each zymolyte are weighed by above-mentioned weight percent, is uniformly mixed to get compound to sow Chinese medicine
Peptide feed addictive.
The usage and dosage of products obtained therefrom are as follows: daily addition, feed usage amount per ton are 1000g.
Comparative example 1
A broad sow Chinese medicine complex peptides feed addictive has been made in this comparative example based on embodiment 1, and coloured malt is replaced
It changes stir-baked MASSA FERMENTATA MEDICI-NALIS similar with its pharmacological property, effect into, luffa is substituted for pueraria lobata similar with its pharmacological property, effect, other compositions
It is constant.Preparation method and application method are the same as embodiment 1.
Comparative example 2
A broad sow Chinese medicine complex peptides feed addictive has been made in this comparative example based on embodiment 1, will all have work
The Radix Angelicae Sinensis of blood stagnation resolvation effect is exchanged with hawthorn dosage, and the Rhizoma Chuanxiong for all having promoting the circulation of qi effect is adjusted with coloured malt dosage
Change, specifically include following components: soybean peptide 67.4g, Radix Astragali zymolyte 4.7g, Radix Angelicae Sinensis zymolyte 2.5g, Rhizoma Chuanxiong zymolyte 2.0g,
Cortex Eucommiae zymolyte 4.1g, seed of cowherb zymolyte 2.9g, hawthorn zymolyte 4.7g, dandelion zymolyte 2.0g, coloured malt enzymatic hydrolysis
Object 4.5g, luffa zymolyte 1.7g, peppermint zymolyte 1.5g and rhizoma zingiberis zymolyte 1.5g.Preparation method and application method are same
Embodiment 1.
Effect example
Embodiment 1,4,5 and comparative example 1,2 products obtained therefroms are analyzed.
Experimental animal: weight differences < 5%, production performance, the 2nd~4 tire Suprapubic arch sling 120 (being deep county pig),
6 groups, respectively blank group, example 1 group, 4 groups of embodiment, 5 groups of embodiment, 1 group of comparative example and 2 groups of comparative example are randomly divided into,
Every group 20.
Test method: selection rate lower July~August living young is tested, and after breeding, each group is using identical conventional day
Grain is fed, and feeding environment condition, management condition are completely the same.Embodiment 1,4,5 and comparative example 1,2 products obtained therefroms are pressed
500g/ tons of dosage is added in the other feed of respective sets, and blank group uses un-added feed.It is continuous to feed 60 days, record
Each group litter size, Birth weight, the average weight of wean, nursery-age pig morbidity number and death toll, continue to feed 30 days after wean, record
The feed conversion rate of each group sow, the results are shown in Table 1.
Table 1
Note: average to live young rate, wean averagely weight, the embodiment each group of feedstuff-meat ratio and comparative example group compared to the blank group, P <
0.05；Embodiment each group is compared with comparative example group, P < 0.05.
As 1 test result of table as it can be seen that sow Chinese medicine complex peptides feed addictive provided by the embodiment of the present invention can be shown
The nest production young rate living that improves, average heavy, the average weight of wean of birth and feedstuff-meat ratio are write, and is substantially reduced the disease incidence of nursery-age pig
And the death rate, and indices are better than comparative example.Illustrate that sow Chinese medicine complex peptides feed provided by the present invention can be mentioned obviously
The sow general level of the health is risen, feed conversion rate, piglet survival ratio, nursing period weight gain and disease resistance are significantly improved.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all in essence of the invention
Made any modification, equivalent replacement or improvement etc., should all be included in the protection scope of the present invention within mind and principle.
Claims (10)
1. a broad sow Chinese medicine complex peptides feed addictive, which is characterized in that including following components in percentage by weight: soybean peptide
62.4~73.4%, Radix Astragali zymolyte 4.2~5.2%, Radix Angelicae Sinensis zymolyte 4.2~5.2%, Rhizoma Chuanxiong zymolyte 4.0~5.0%,
Cortex Eucommiae zymolyte 3.6~4.6%, seed of cowherb zymolyte 2.4~3.4%, hawthorn zymolyte 2.0~3.0%, dandelion enzymatic hydrolysis
Object 1.5~2.5%, coloured malt zymolyte 1.5~2.5%, luffa zymolyte 1.2~2.2%, peppermint zymolyte 1.0~
2.0% and rhizoma zingiberis zymolyte 1.0~2.0%, the soybean peptide and each zymolyte are by corresponding raw material through cellulase, fat
Enzyme, amylase and neutral proteinase obtain after being digested.
2. sow Chinese medicine complex peptides feed addictive according to claim 1, which is characterized in that including following weight percent
The component of ratio: soybean peptide 65.4~70.4%, Radix Astragali zymolyte 4.5~4.9%, Radix Angelicae Sinensis zymolyte 4.5~4.9%, Rhizoma Chuanxiong enzyme
Solution object 4.3~4.7%, Cortex Eucommiae zymolyte 3.8~4.3%, seed of cowherb zymolyte 2.6~3.2%, hawthorn zymolyte 2.2~
2.8%, dandelion zymolyte 1.8~2.2%, coloured malt zymolyte 1.8~2.2%, luffa zymolyte 1.5~2.0%, thin
Lotus zymolyte 1.3~1.7% and rhizoma zingiberis zymolyte 1.3~1.7%.
3. sow Chinese medicine complex peptides feed addictive according to claim 2, which is characterized in that including following weight percent
The component of ratio: soybean peptide 67.9%, Radix Astragali zymolyte 4.7%, Radix Angelicae Sinensis zymolyte 4.7%, Rhizoma Chuanxiong zymolyte 4.5%, Cortex Eucommiae enzyme
Solve object 4.1%, seed of cowherb zymolyte 2.9%, hawthorn zymolyte 2.5%, dandelion zymolyte 2.0%, coloured malt zymolyte
2.0%, luffa zymolyte 1.7%, peppermint zymolyte 1.5% and rhizoma zingiberis zymolyte 1.5%.
4. a kind of preparation method of any one of claims 1 to 3 sow Chinese medicine complex peptides feed addictive, feature exist
In, specifically includes the following steps:
Step a, by the raw soybeans dregs of rice, Radix Astragali, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Cortex Eucommiae, the seed of cowherb, hawthorn, dandelion, coloured malt, sponge gourd
Network, peppermint and rhizoma zingiberis are respectively placed in 7~8h of decoction in purified water, obtain decocting medical fluid accordingly；
Step b, cellulase, lipase, amylase and neutral proteinase are used respectively into each decoction medical fluid obtained by step a
It is digested, obtains corresponding enzymolysis liquid；
Step c, each enzymolysis liquid obtained by step b is separated by solid-liquid separation respectively, gained liquid is purified respectively, be concentrated, is done
It is dry, soybean peptide and each zymolyte are obtained, weighs the soybean peptide and each zymolyte by weight percentages of components, is mixed
Uniformly to get.
5. the preparation method of sow Chinese medicine complex peptides feed addictive according to claim 4, which is characterized in that step a
Described in water weight be the Soybean Meal, Radix Astragali, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Cortex Eucommiae, the seed of cowherb, hawthorn, dandelion, coloured malt, silk
7~8 times of the respective weight of melon network, peppermint and rhizoma zingiberis.
6. the preparation method of sow Chinese medicine complex peptides feed addictive according to claim 4, which is characterized in that step a
The temperature of middle decoction is 90~95 DEG C.
7. the preparation method of sow Chinese medicine complex peptides feed addictive according to claim 4, which is characterized in that step b
Described in cellulase be Li Shi trichoderma cellulase, dosage be step a described in each raw material original weight amount 1.5~2%；It is described
For lipase by Rhizopus oryzae lipase, dosage is 1.5~2% of each raw material original weight amount described in step a；The amylase is black song
Mould amylase, dosage are 1~1.5% of each raw material original weight amount described in step a；The neutral proteinase is Aspergillus oryzae protease
Enzyme, dosage are 1~1.5% of each raw material original weight amount described in step a.
8. the preparation method of sow Chinese medicine complex peptides feed addictive according to claim 7, which is characterized in that step b
The condition of middle enzymatic hydrolysis are as follows: 3.0~4.0h of stirring enzymatic hydrolysis under the conditions of 56~58 DEG C then heats to 90~95 DEG C, keep 10~
15min enzyme deactivation.
9. the preparation method of sow Chinese medicine complex peptides feed addictive according to claim 4, which is characterized in that step c
Described in separation of solid and liquid operation be centrifugation after filter, centrifugal rotational speed be 3400~3800r/min；And/or
Purifying described in step c carries out in three-phase centrifuge, and centrifugal rotational speed is 17000~19000r/min.
10. the preparation method of sow Chinese medicine complex peptides feed addictive according to claim 4, which is characterized in that step c
Described in it is dry for spray drying.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112641009A (en) * | 2020-12-22 | 2021-04-13 | 清远一生自然生物研究院有限公司 | Boar health-care feed additive composition and application thereof |
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| CN103355499A (en) * | 2013-07-29 | 2013-10-23 | 广南(湛江)家丰饲料有限公司 | Feed addictive for improving pork quality and increasing efficiency of feed utilization and preparation thereof |
| CN106036121A (en) * | 2016-07-28 | 2016-10-26 | 无为县三公山特种养殖场 | Feed for lactation sow |
| CN108065077A (en) * | 2017-12-23 | 2018-05-25 | 湖南盛东生物科技有限公司 | Improve the Chinese herbal feed additive and preparation and application of sow production performance |
| CN109481513A (en) * | 2018-12-28 | 2019-03-19 | 河北肽都生物科技有限公司 | A kind of Chinese medicine peptide and preparation method thereof for preventing and treating pig blue-ear disease |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103355499A (en) * | 2013-07-29 | 2013-10-23 | 广南(湛江)家丰饲料有限公司 | Feed addictive for improving pork quality and increasing efficiency of feed utilization and preparation thereof |
| CN106036121A (en) * | 2016-07-28 | 2016-10-26 | 无为县三公山特种养殖场 | Feed for lactation sow |
| CN108065077A (en) * | 2017-12-23 | 2018-05-25 | 湖南盛东生物科技有限公司 | Improve the Chinese herbal feed additive and preparation and application of sow production performance |
| CN109481513A (en) * | 2018-12-28 | 2019-03-19 | 河北肽都生物科技有限公司 | A kind of Chinese medicine peptide and preparation method thereof for preventing and treating pig blue-ear disease |
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| CN112641009A (en) * | 2020-12-22 | 2021-04-13 | 清远一生自然生物研究院有限公司 | Boar health-care feed additive composition and application thereof |
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