CN105362415A - Medicine for treating appendicitis and method for preparing medicine - Google Patents
Medicine for treating appendicitis and method for preparing medicine Download PDFInfo
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- CN105362415A CN105362415A CN201510882190.9A CN201510882190A CN105362415A CN 105362415 A CN105362415 A CN 105362415A CN 201510882190 A CN201510882190 A CN 201510882190A CN 105362415 A CN105362415 A CN 105362415A
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- A61K2236/30—Extraction of the material
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Abstract
The invention discloses a medicine for treating appendicitis and a method for preparing the medicine. The medicine which is a traditional Chinese medicine composition mainly comprises aristolochia howii, launaea acaulis, patrinia rupestris, Artemisia sacrorum, trollius macropetalus, tanacetum variifolium (chang) ling, lxeris polycephala, picris divaricata, xanthium sibiricum roots, shuteria pampaninianna, lespedeza dunnii, lxeris debilis, osbeckia chinensis, hedyotis tenelliflora and glossogyne tenuifolia. The method on the basis of different service processes of various medicines includes decocting and extracting the aristolochia howii, the launaea acaulis, the patrinia rupestris, the trollius macropetalus, the tanacetum variifolium (chang) ling, the shuteria pampaninianna, the osbeckia chinensis, the hedyotis tenelliflora and the glossogyne tenuifolia thrice to obtain extract liquid; filtering the extract liquid; washing and squeezing the lxeris polycephala, the xanthium sibiricum roots and the lespedeza dunnii to obtain juice; filtering impurities in the juice; roasting and smashing the Artemisia sacrorum, the picris divaricata and the lxeris debilis to obtain powder; mixing filter liquid and the powder with each other to obtain mixtures; heating and concentrating the mixtures to obtain thick paste; drying the thick paste and adding excipients into the thick paste to prepare tablets. The medicine and the method have the advantages that unique curative effects can be realized by the medicine for treating the appendicitis, effects of activating blood, promoting qi circulation to relieve pain, resolving lump and diminishing swelling can be realized, and the medicine is convenient to take and free of optional toxic and side effects and can become effective fast.
Description
Technical field
The present invention relates to technical field of Chinese medicines, particularly relate to one and treat typhlitic medicine and preparation method.
Background technology
Appendicitis refers to that the inflammatory that vermiform appendix is formed due to many factors changes, a kind of common Abdominal Surgery.Early stage diagnosis and treatment, patient is many can rehabilitation in a short time, if delay diagnosis and treatment can play serious complication, even causes death.Transitivity right lower abdominal pain and McBurney's point tenderness, rebound tenderness are its common clinical manifestation, and clinical manifestation is the right lower abdominal pain, Nausea and vomiting, heating, inappetence etc. that continue the aggravation of companion's paroxysmal., the typhlitic method for the treatment of comprises operation and non-operative treatment at present, must perform the operation immediately for the serious situation of infection, generally, for avoiding operative treatment to injure and issuable sequela, takes non-operative treatment.Therefore, finding one effectively can treat typhlitic medicine is urgent problem.
Summary of the invention
The invention provides a kind of evident in efficacy, taking convenience, safe and reliable one and treat typhlitic medicine.
Another object of the present invention is to provide described a kind of preparation method for the treatment of typhlitic medicine.
For realizing above-mentioned first object, technical scheme of the present invention is: one treats typhlitic medicine, and component meter is made up of following raw material by weight: southern Guangdong Fructus Aristolochiae 50-68 part, Herba launaeae acaulis root 46-62 part, Herba Patriniae Rupestris 40-58 part, white lotus Artemisia 35-54 part, longpetal globeflower flower 32-51 part, Herba Tanaceti variifolii 30-48 part, Herba Ixeritis polycephalae 27-47 part, Picris divaricata 25-37 part, Radix Xanthii 22-32 part, HERBA SHUTERIAE 20-28 part, spring China Caulis Seu Folium Lespedezae Bicoloris 15-26 part, Herba ixeritis debilis 12-24 part, Radix Osbeckiae Crinitae 11-22 part, hedyotis tenelliflora Blume 10-20 part, Herba bidentis parviflorae 4-16 part.
Further, described one treats typhlitic medicine, and component meter is made up of following raw material by weight: southern Guangdong Fructus Aristolochiae 59 parts, Herba launaeae acaulis root 54 parts, Herba Patriniae Rupestris 49 parts, white lotus Artemisia 44.5 parts, longpetal globeflower flower 41.5 parts, Herba Tanaceti variifolii 39 parts, Herba Ixeritis polycephalae 37 parts, Picris divaricata 30 parts, Radix Xanthii 27 parts, HERBA SHUTERIAE 24 parts, the spring China Caulis Seu Folium Lespedezae Bicoloris 20.5 parts, Herba ixeritis debilis 18 parts, Radix Osbeckiae Crinitae 16.5 parts, hedyotis tenelliflora Blume 15 parts, Herba bidentis parviflorae 10 parts.
Further, described one treats typhlitic medicine, also comprises following adjuvant: carboxymethylstach sodium 4-10 part, mannitol 3-9 part, crosslinked polyethylene pyrrole alkane ketone 2-5 part, magnesium stearate 2-4 part, sodium alginate 1-3 part.
In described adjuvant, carboxymethylstach sodium is modified starch, tasteless, and the five poisonous creatures: scorpion, viper, centipede, house lizard, toad not easily go mouldy, and soluble in waterly mixes as disintegrating agent with crosslinked polyethylene pyrrole alkane ketone, promotes medicine entrance rapid solution; Mannitol and sodium alginate are binding agent, and wherein mannitol is dilution property binding agent, slightly sweet taste, and can improve medicine taste, sodium alginate possesses stability needed for adjuvant, dissolubility, viscosity and safety; Magnesium stearate is not soluble in water, has soapy feeling with contact skin, as lubricant.
Further, described adjuvant by weight component meter comprise: carboxymethylstach sodium 7 parts, 4 parts, mannitol, crosslinked polyethylene pyrrole alkane ketone 3.5 parts, magnesium stearate 3 parts, sodium alginate 2 parts.
Further, described Herba Ixeritis polycephalae, Radix Xanthii, the spring China Caulis Seu Folium Lespedezae Bicoloris be fresh goods.Fresh goods directly twists the biological activity that juice can keep medicine, can fully extract its effective ingredient.
Further, described a kind of dosage form for the treatment of typhlitic medicine is peroral tablets.
For realizing above-mentioned second object, the technical scheme that the present invention takes is:
Treat a preparation method for typhlitic medicine, comprise the following steps:
(1) the southern Guangdong Fructus Aristolochiae of formula ratio, Herba launaeae acaulis root, Herba Patriniae Rupestris, longpetal globeflower flower, Herba Tanaceti variifolii, HERBA SHUTERIAE, Radix Osbeckiae Crinitae, hedyotis tenelliflora Blume, Herba bidentis parviflorae sorting remove impurity is got, be placed in marmite with cold boiled water wash clean, add 6-8 times amount distilled water, decoct after soaking half an hour, big fire is heated to boiling, turn little fiery 4-6 hour, extract; Add 4-6 times amount distilled water again, big fire is boiled, and turns little fiery 2-4 hours, extracts; Finally, add 2-4 times amount distilled water, boil and turn little fiery 1-2 hour, extract; Merge three extracting solution, filter, liquid stay is for subsequent use;
(2) get the Herba Ixeritis polycephalae of formula ratio, Radix Xanthii fresh goods, clean, chopping, strand juice, filters out impurities, stays juice for subsequent use;
(3) that gets formula ratio gets formula ratio spring China Caulis Seu Folium Lespedezae Bicoloris, and clean with cold boiled water and smash to pieces, add 1-3 times amount second time washing water of rice mix homogeneously (washing water of rice is cold boiled water), heated and boiled 30 minutes, cooling, filter, liquid stay is for subsequent use;
(4) get the white lotus Artemisia of formula ratio, Picris divaricata, Herba ixeritis debilis remove impurity clean, spray rice vinegar infiltrate 12-24 minute, insert frying pan slow fire heating, dry in the air after fried dry cool, then pulverize, grind into powder, 80-100 order fine powder must be, for subsequent use;
(5) thick paste, juice and fine powder mixing above-mentioned steps (1), (2), (3), (4) obtained, it is the thick paste of 1.20-1.24 that heating is condensed into relative density at 60 DEG C, dry, pulverize as 16-18 order granule, add carboxymethylstach sodium in mass ratio, mannitol, crosslinked polyethylene pyrrole alkane ketone, magnesium stearate, sodium alginate stir, be compressed to tablet.
The pharmacologically active of each raw material of Chinese medicine of the present invention is as follows:
Guangdong, south Fructus Aristolochiae: [nature and flavor] are bitter, cold.[function cures mainly] heat-clearing and toxic substances removing.Asthmatic tracheitis; Infantile pneumonia; Bacillary dysentery and mastitis; Appendicitis; Cutization pyogenic infection.
Herba launaeae acaulis root: [nature and flavor] sweet, bitter, cold.[function cures mainly] heat-clearing and toxic substances removing.Dyspepsia, urinary tract infection, conjunctivitis, appendicitis; Furuncle and phyma, parotitis, mastitis.
Herba Patriniae Rupestris: [nature and flavor] are bitter, cold.[function cures mainly] heat-clearing and toxic substances removing, invigorates blood circulation, evacuation of pus; Enteritis, dysentery, appendicitis, hepatitis.
White lotus Artemisia: [nature and flavor] are bitter, pungent, flat.[function cures mainly] cooling blood and relieving pain.Hepatitis, appendicitis, infantile convulsion, deficiency of YIN hectic fever; Wound hemorrhage.
Longpetal globeflower flower: [nature and flavor] bitter in the mouth; Cold in nature.[function cures mainly] heat-clearing and toxic substances removing.Your Majesty's respiratory tract infection; Acute and chronic tonsillitis; Acute conjunctivitis; Acute otitis media; Acute dysentery; Acute appendicitis.
Herba Tanaceti variifolii: [nature and flavor] pungent micro-hardship; Flat.[function cures mainly] dispels the wind calmness, heat-clearing and toxic substances removing.Control infantile convulsion, rheumatic numbness, appendicitis.
Herba Ixeritis polycephalae: [nature and flavor] are bitter, sweet, cool.[function cures mainly] heat-clearing and toxic substances removing, dampness removing disappears painful abdominal mass; Externally applied anti-inflammation detumescent.Cure mainly lung-heat laryngalgia, stomachache, mass in the abdomen, appendicitis; Furuncle swelling toxin is controlled in external, acute mastitis, conjunctival congestion and swelling pain, skin rubella.
Picris divaricata: [nature and flavor] are bitter, cold.[function cures mainly] heat-clearing and toxic substances removing, cooling blood for hemostasis.For enteritis, dysentery, acute icteric infectious hepatitis, appendicitis, mastitis, stomatitis, pharyngitis, tonsillitis, spits blood, epistaxis, and spitting of blood, has blood in stool, metrorrhagia; Carbuncle pyogenic infections from tumour or sore is controlled in external, otitis media
Radix Xanthii: [nature and flavor] temperature.[function cures mainly] controls furuncle, carbuncle, bond-throat syndrome, erysipelas, hypertension.
HERBA SHUTERIAE: [nature and flavor] are bitter, cold.[function cures mainly] heat-clearing and toxic substances removing, detumescence.For appendicitis, mastitis, parotitis, hemoptysis of pulmonary tuberculosis.
Spring China Caulis Seu Folium Lespedezae Bicoloris: [function cures mainly] controls acute appendicitis.
Herba ixeritis debilis: [nature and flavor] are bitter, cold.[function cures mainly]: clearing away heat and cooling blood, inducing diuresis to remove edema.For cough due to lung-heat, laryngalgia, oral ulcer, acute conjunctivitis, appendicitis, edema, dysuria; Mastitis are controlled in external, furuncle toxic swelling, skin pruritus.
Radix Osbeckiae Crinitae: [nature and flavor] are light is flat.[function cures mainly] clearing away heat-damp and promoting diuresis, subduing swelling and detoxicating, relieving cough and resolving phlegm.For acute bacillary dysentery, amebic dysentery, ameba liver abscess, enteritis, cold cough, laryngopharynx swelling and pain, bronchial asthma of child, hemoptysis of pulmonary tuberculosis, appendicitis, venom, furuncle furuncle and phyma.
Hedyotis tenelliflora Blume: [nature and flavor] are bitter, pungent, cool.[function cures mainly] reducing swelling and alleviating pain.For cancer, appendicitis, dysentery; Traumatic injury is controlled in external, venom.
Herba bidentis parviflorae: [nature and flavor] are bitter, cool.[function cures mainly] blood circulation and promoting silt.Cure cold heating, laryngalgia, enteritis, diarrhea, appendicitis, traumatic injury, carbuncle furuncle.
Beneficial effect of the present invention is embodied in: it is reasonable that one of the present invention treats typhlitic pharmaceutical formulation, selected medical material compatibility is suitable, meets Chinese medicine and pharmacy and modern medicine theory, has unique curative effect to treatment appendicitis, have invigorate blood circulation, promoting the circulation of QI to relieve pain, mass dissipating and swelling eliminating, effect of heat-clearing and toxic substances removing, evident in efficacy, safe and reliable, without any side effects, be used for the treatment of vermiform appendix inflammation and cause stomachache, feel sick, the symptom such as heating, cost is lower, wide popularization and application on clinic.
Detailed description of the invention
Below in conjunction with detailed description of the invention, the present invention is described in more detail:
Embodiment 1: one treats typhlitic medicine, component meter is made up of following raw material by weight: southern Guangdong Fructus Aristolochiae 50 parts, Herba launaeae acaulis root 46 parts, Herba Patriniae Rupestris 40 parts, white lotus Artemisia 35 parts, longpetal globeflower flower 32 parts, Herba Tanaceti variifolii 30 parts, Herba Ixeritis polycephalae 27 parts, Picris divaricata 25 parts, Radix Xanthii 22 parts, HERBA SHUTERIAE 20 parts, the spring China Caulis Seu Folium Lespedezae Bicoloris 15 parts, Herba ixeritis debilis 12 parts, Radix Osbeckiae Crinitae 11 parts, hedyotis tenelliflora Blume 10 parts, Herba bidentis parviflorae 4 parts, carboxymethylstach sodium 4 parts, 3 parts, mannitol, crosslinked polyethylene pyrrole alkane ketone 2 parts, magnesium stearate 2 parts, sodium alginate 1 part.
Wherein, carboxymethylstach sodium is modified starch, tasteless, and the five poisonous creatures: scorpion, viper, centipede, house lizard, toad not easily go mouldy, and soluble in waterly mixes as disintegrating agent with crosslinked polyethylene pyrrole alkane ketone, promotes medicine entrance rapid solution; Mannitol and sodium alginate are binding agent, and wherein mannitol is dilution property binding agent, slightly sweet taste, and can improve medicine taste, sodium alginate possesses stability needed for adjuvant, dissolubility, viscosity and safety; Magnesium stearate is not soluble in water, has soapy feeling with contact skin, as lubricant.
A kind of preparation method for the treatment of typhlitic medicine is:
(1) the southern Guangdong Fructus Aristolochiae of formula ratio, Herba launaeae acaulis root, Herba Patriniae Rupestris, longpetal globeflower flower, Herba Tanaceti variifolii, HERBA SHUTERIAE, Radix Osbeckiae Crinitae, hedyotis tenelliflora Blume, Herba bidentis parviflorae sorting remove impurity is got, be placed in marmite with cold boiled water wash clean, add 6 times amount distilled water, decoct after soaking half an hour, big fire is heated to boiling, turn little fiery 4 hours, extract; Add 4 times amount distilled water again, big fire is boiled, and turns little fiery 2 hours, extracts; Finally, add 2 times amount distilled water, boil and turn little fiery 1 hour, extract; Merge three extracting solution, filter, liquid stay is for subsequent use;
(2) get the Herba Ixeritis polycephalae of formula ratio, Radix Xanthii fresh goods, clean, chopping, strand juice, filters out impurities, stays juice for subsequent use;
(3) that gets formula ratio gets formula ratio spring China Caulis Seu Folium Lespedezae Bicoloris, and clean with cold boiled water and smash to pieces, add 1 times amount second time washing water of rice mix homogeneously (washing water of rice is cold boiled water), heated and boiled 30 minutes, cooling, filter, liquid stay is for subsequent use;
(4) get the white lotus Artemisia of formula ratio, Picris divaricata, Herba ixeritis debilis remove impurity clean, spray rice vinegar infiltrate 12 minutes, insert frying pan slow fire heating, dry in the air after fried dry cool, then pulverize, grind into powder, 80 order fine powders must be, for subsequent use;
(5) thick paste, juice and fine powder mixing above-mentioned steps (1), (2), (3), (4) obtained, it is the thick paste of 1.20 that heating is condensed into relative density at 60 DEG C, dry, pulverizing is 16 order granules, add carboxymethylstach sodium in mass ratio, mannitol, crosslinked polyethylene pyrrole alkane ketone, magnesium stearate, sodium alginate stir, be compressed to tablet.
Embodiment 2: one treats typhlitic medicine, component meter is made up of following raw material by weight: southern Guangdong Fructus Aristolochiae 59 parts, Herba launaeae acaulis root 54 parts, Herba Patriniae Rupestris 49 parts, white lotus Artemisia 44.5 parts, longpetal globeflower flower 41.5 parts, Herba Tanaceti variifolii 39 parts, Herba Ixeritis polycephalae 37 parts, Picris divaricata 30 parts, Radix Xanthii 27 parts, HERBA SHUTERIAE 24 parts, the spring China Caulis Seu Folium Lespedezae Bicoloris 20.5 parts, Herba ixeritis debilis 18 parts, Radix Osbeckiae Crinitae 16.5 parts, hedyotis tenelliflora Blume 15 parts, Herba bidentis parviflorae 10 parts, carboxymethylstach sodium 7 parts, 6 parts, mannitol, crosslinked polyethylene pyrrole alkane ketone 3.5 parts, magnesium stearate 3 parts, sodium alginate 2 parts.
Wherein, carboxymethylstach sodium is modified starch, tasteless, and the five poisonous creatures: scorpion, viper, centipede, house lizard, toad not easily go mouldy, and soluble in waterly mixes as disintegrating agent with crosslinked polyethylene pyrrole alkane ketone, promotes medicine entrance rapid solution; Mannitol and sodium alginate are binding agent, and wherein mannitol is dilution property binding agent, slightly sweet taste, and can improve medicine taste, sodium alginate possesses stability needed for adjuvant, dissolubility, viscosity and safety; Magnesium stearate is not soluble in water, has soapy feeling with contact skin, as lubricant.
A kind of preparation method for the treatment of typhlitic medicine is:
(1) the southern Guangdong Fructus Aristolochiae of formula ratio, Herba launaeae acaulis root, Herba Patriniae Rupestris, longpetal globeflower flower, Herba Tanaceti variifolii, HERBA SHUTERIAE, Radix Osbeckiae Crinitae, hedyotis tenelliflora Blume, Herba bidentis parviflorae sorting remove impurity is got, be placed in marmite with cold boiled water wash clean, add 7 times amount distilled water, decoct after soaking half an hour, big fire is heated to boiling, turn little fiery 5 hours, extract; Add 5 times amount distilled water again, big fire is boiled, and turns little fiery 3 hours, extracts; Finally, add 3 times amount distilled water, boil and turn little fiery 1.5 hours, extract; Merge three extracting solution, filter, liquid stay is for subsequent use;
(2) get the Herba Ixeritis polycephalae of formula ratio, Radix Xanthii fresh goods, clean, chopping, strand juice, filters out impurities, stays juice for subsequent use;
(3) that gets formula ratio gets formula ratio spring China Caulis Seu Folium Lespedezae Bicoloris, and clean with cold boiled water and smash to pieces, add 2 times amount second time washing water of rice mix homogeneously (washing water of rice is cold boiled water), heated and boiled 30 minutes, cooling, filter, liquid stay is for subsequent use;
(4) get the white lotus Artemisia of formula ratio, Picris divaricata, Herba ixeritis debilis remove impurity clean, spray rice vinegar infiltrate 18 minutes, insert frying pan slow fire heating, dry in the air after fried dry cool, then pulverize, grind into powder, 90 order fine powders must be, for subsequent use;
(5) thick paste, juice and fine powder mixing above-mentioned steps (1), (2), (3), (4) obtained, it is the thick paste of 1.22 that heating is condensed into relative density at 60 DEG C, dry, pulverizing is 17 order granules, add carboxymethylstach sodium in mass ratio, mannitol, crosslinked polyethylene pyrrole alkane ketone, magnesium stearate, sodium alginate stir, be compressed to tablet.
Embodiment 3: one treats typhlitic medicine, component meter is made up of following raw material by weight: southern Guangdong Fructus Aristolochiae 68 parts, Herba launaeae acaulis root 62 parts, Herba Patriniae Rupestris 58 parts, white lotus Artemisia 54 parts, longpetal globeflower flower 51 parts, Herba Tanaceti variifolii 48 parts, Herba Ixeritis polycephalae 47 parts, Picris divaricata 37 parts, Radix Xanthii 32 parts, HERBA SHUTERIAE 28 parts, the spring China Caulis Seu Folium Lespedezae Bicoloris 26 parts, Herba ixeritis debilis 24 parts, Radix Osbeckiae Crinitae 22 parts, hedyotis tenelliflora Blume 20 parts, Herba bidentis parviflorae 16 parts, carboxymethylstach sodium 10 parts, 9 parts, mannitol, crosslinked polyethylene pyrrole alkane ketone 5 parts, magnesium stearate 4 parts, sodium alginate 3 parts.
Wherein, carboxymethylstach sodium is modified starch, tasteless, and the five poisonous creatures: scorpion, viper, centipede, house lizard, toad not easily go mouldy, and soluble in waterly mixes as disintegrating agent with crosslinked polyethylene pyrrole alkane ketone, promotes medicine entrance rapid solution; Mannitol and sodium alginate are binding agent, and wherein mannitol is dilution property binding agent, slightly sweet taste, and can improve medicine taste, sodium alginate possesses stability needed for adjuvant, dissolubility, viscosity and safety; Magnesium stearate is not soluble in water, has soapy feeling with contact skin, as lubricant.
A kind of preparation method for the treatment of typhlitic medicine is:
(1) the southern Guangdong Fructus Aristolochiae of formula ratio, Herba launaeae acaulis root, Herba Patriniae Rupestris, longpetal globeflower flower, Herba Tanaceti variifolii, HERBA SHUTERIAE, Radix Osbeckiae Crinitae, hedyotis tenelliflora Blume, Herba bidentis parviflorae sorting remove impurity is got, be placed in marmite with cold boiled water wash clean, add 8 times amount distilled water, decoct after soaking half an hour, big fire is heated to boiling, turn little fiery 6 hours, extract; Add 6 times amount distilled water again, big fire is boiled, and turns little fiery 4 hours, extracts; Finally, add 4 times amount distilled water, boil and turn little fiery 3 hours, extract; Merge three extracting solution, filter, liquid stay is for subsequent use;
(2) get the Herba Ixeritis polycephalae of formula ratio, Radix Xanthii fresh goods, clean, chopping, strand juice, filters out impurities, stays juice for subsequent use;
(3) that gets formula ratio gets formula ratio spring China Caulis Seu Folium Lespedezae Bicoloris, and clean with cold boiled water and smash to pieces, add 3 times amount second time washing water of rice mix homogeneously (washing water of rice is cold boiled water), heated and boiled 30 minutes, cooling, filter, liquid stay is for subsequent use;
(4) get the white lotus Artemisia of formula ratio, Picris divaricata, Herba ixeritis debilis remove impurity clean, spray rice vinegar infiltrate 24 minutes, insert frying pan slow fire heating, dry in the air after fried dry cool, then pulverize, grind into powder, 100 order fine powders must be, for subsequent use;
(5) thick paste, juice and fine powder mixing above-mentioned steps (1), (2), (3), (4) obtained, it is the thick paste of 1.24 that heating is condensed into relative density at 60 DEG C, dry, pulverizing is 18 order granules, add carboxymethylstach sodium in mass ratio, mannitol, crosslinked polyethylene pyrrole alkane ketone, magnesium stearate, sodium alginate stir, be compressed to tablet.
Clinical trial:
1. clinical case is selected
Choice criteria: choose appendicitis morbidity more anxious, there is transitivity right lower abdominal pain severe pain, companion's nausea and vomiting and heating in various degree, Right Lower Abdomen local tenderness, rebound tenderness and tension of abdominal muscle, numeration of leukocyte and neutrophil cell increase, and routine urinalysis and breast abdomen perspective normally, get rid of patient 315 example of other intestinal tract diseases, gynecological and internal disease, man 183 example, female 132 example, is divided into three groups at random, often organizes 105 people.
2. test method:
To the medicine that first group is prepared by the embodiment of the present invention 1, oral, every day three times, each 2, warm water takes after meal; 10 days courses for the treatment of, be used in conjunction 3 courses for the treatment of;
To the medicine that second group is prepared by the embodiment of the present invention 2, oral, every day three times, each 2, warm water takes after meal; 8 days courses for the treatment of, be used in conjunction 3 courses for the treatment of;
To the medicine that the 3rd group is prepared by the embodiment of the present invention 3, oral, every day three times, each 2, warm water takes after meal; 6 days courses for the treatment of, be used in conjunction 3 courses for the treatment of;
3. criterion of therapeutical effect and therapeutic outcome
3.1 criterion of therapeutical effect
(1) fully recover: the symptoms such as right lower abdomen pain, vomiting, heating all disappear, and physical recovery is normal;
(2) effective: the symptoms such as right lower abdomen pain, vomiting, heating alleviate to some extent, and health takes a turn for the better to some extent;
(3) invalid: the symptoms such as right lower abdomen pain, vomiting, body temperature rising are without alleviating or increasing the weight of.
3.2 treatment statistical results
Three groups of data merge statistics, recovery from illness: 282 examples, effectively: 27 examples, invalid: 6 examples.
4. conclusion: in clinical trial process, the patient accepting Drug therapy of the present invention finds no any untoward reaction, and stomachache in various degree, vomiting etc. that patient occurs mostly can be fully recovered, and do not occur untoward reaction, physical recovery is normal, suitably increases further can improve cure rate the course for the treatment of depending on the state of an illness.From data, medicine of the present invention is to treatment appendicitis Be very effective, and total effective rate reaches more than 98%, can cure and without recurrence, safe and reliable, cost is lower, wide popularization and application on clinic.
5. clinical individual case
Case 1: go into business certain, man, 27 years old, people from Wuhan, Hubei.Patient's Right Lower Abdomen pain, during cough, the pain increased, vermiform appendix cave tenderness, rebound tenderness, and tension of abdominal muscle is not obvious, take antibiotic medication, therapeutic effect is not good, after take Drug therapy of the present invention, after taking a course for the treatment of, symptom obviously alleviates, after continuing to take 2 courses for the treatment of, and transference cure, recovery from illness.
Case 2: Zhang, female, 21 years old, people from Yichuan, Shaanxi.Patient's Right Lower Abdomen pain, with heating, body temperature 39 DEG C, feel sick and diarrhoea, be diagnosed as appendicitis, after taking a course for the treatment of of medicine of the present invention, symptom is alleviated to some extent, and after taking three courses for the treatment of, transference cure, recovery from illness, without recurrence.
Case 3: Lee, female, 40 years old, Henan people from Zhoukou City.Having an intense pain appears in patient's abdominal part, can not directly waist, and heating, takes other drug and do not take a turn for the better, and after taking a course for the treatment of of medicine of the present invention by doctor formula, stomachache obviously alleviates, and without heating, after continuing to take two courses for the treatment of, transference cure, health is fully recovered.
Last it is noted that above embodiment is only in order to illustrate technical scheme of the present invention, be not intended to limit; Although with reference to previous embodiment to invention has been detailed description, those of ordinary skill in the art is to be understood that: it still can be modified to the technical scheme described in previous embodiment, or carries out equivalent replacement to wherein portion of techniques feature; And these amendments or replacement, do not make the essence of appropriate technical solution depart from the spirit and scope of embodiment of the present invention technical scheme.
Claims (8)
1. treat a typhlitic medicine, it is characterized in that component meter is made up of following raw material by weight: southern Guangdong Fructus Aristolochiae 50-68 part, Herba launaeae acaulis root 46-62 part, Herba Patriniae Rupestris 40-58 part, white lotus Artemisia 35-54 part, longpetal globeflower flower 32-51 part, Herba Tanaceti variifolii 30-48 part, Herba Ixeritis polycephalae 27-47 part, Picris divaricata 25-37 part, Radix Xanthii 22-32 part, HERBA SHUTERIAE 20-28 part, spring China Caulis Seu Folium Lespedezae Bicoloris 15-26 part, Herba ixeritis debilis 12-24 part, Radix Osbeckiae Crinitae 11-22 part, hedyotis tenelliflora Blume 10-20 part, Herba bidentis parviflorae 4-16 part.
2. one as claimed in claim 1 treats typhlitic medicine, it is characterized in that component meter is made up of following raw material by weight: southern Guangdong Fructus Aristolochiae 59 parts, Herba launaeae acaulis root 54 parts, Herba Patriniae Rupestris 49 parts, white lotus Artemisia 44.5 parts, longpetal globeflower flower 41.5 parts, Herba Tanaceti variifolii 39 parts, Herba Ixeritis polycephalae 37 parts, Picris divaricata 30 parts, Radix Xanthii 27 parts, HERBA SHUTERIAE 24 parts, the spring China Caulis Seu Folium Lespedezae Bicoloris 20.5 parts, Herba ixeritis debilis 18 parts, Radix Osbeckiae Crinitae 16.5 parts, hedyotis tenelliflora Blume 15 parts, Herba bidentis parviflorae 10 parts.
3. one as claimed in claim 1 or 2 treats typhlitic medicine, characterized by further comprising following adjuvant: carboxymethylstach sodium 4-10 part, mannitol 3-9 part, crosslinked polyethylene pyrrole alkane ketone 2-5 part, magnesium stearate 2-4 part, sodium alginate 1-3 part.
4. one as claimed in claim 3 treats typhlitic medicine, it is characterized in that described adjuvant by weight component meter comprise: carboxymethylstach sodium 7 parts, 6 parts, mannitol, crosslinked polyethylene pyrrole alkane ketone 3.5 parts, magnesium stearate 3 parts, sodium alginate 2 parts.
5. one as claimed in claim 1 or 2 treats typhlitic medicine, it is characterized in that described Herba Ixeritis polycephalae, Radix Xanthii, the spring China Caulis Seu Folium Lespedezae Bicoloris be fresh goods.
6. one as claimed in claim 1 or 2 treats typhlitic medicine, it is characterized in that described white lotus Artemisia, Picris divaricata, Herba ixeritis debilis need fried dry to pulverize.
7. the one as described in claim 1 to 6 treats typhlitic medicine, it is characterized in that the dosage form of described medicine is peroral tablets.
8. a kind of preparation method for the treatment of typhlitic medicine as claimed in claim 7, is characterized in that comprising the following steps:
(1) the southern Guangdong Fructus Aristolochiae of formula ratio, Herba launaeae acaulis root, Herba Patriniae Rupestris, longpetal globeflower flower, Herba Tanaceti variifolii, HERBA SHUTERIAE, Radix Osbeckiae Crinitae, hedyotis tenelliflora Blume, Herba bidentis parviflorae sorting remove impurity is got, be placed in container with cold boiled water wash clean, add 6-8 times amount distilled water, decoct after soaking half an hour, big fire is heated to boiling, turn little fiery 4-6 hour, extract; Add 4-6 times amount distilled water again, big fire is boiled, and turns little fiery 2-4 hour, extracts; Finally, add 2-4 times amount distilled water, boil and turn little fiery 1-2 hour, extract; Merge three extracting solution, filter, liquid stay is for subsequent use;
(2) get the Herba Ixeritis polycephalae of formula ratio, Radix Xanthii fresh goods, clean, chopping, strand juice, filters out impurities, stays juice for subsequent use;
(3) get formula ratio spring China Caulis Seu Folium Lespedezae Bicoloris, clean and smash to pieces, add 1-3 times amount second time washing water of rice mix homogeneously, heated and boiled, cooling, filter, liquid stay is for subsequent use;
(4) get the white lotus Artemisia of formula ratio, Picris divaricata, Herba ixeritis debilis remove impurity clean, spray rice vinegar infiltrate 12-24 minute, slow fire heat, dry in the air after fried dry cool, then pulverize, grind into powder, 80-100 order fine powder must be, for subsequent use;
(5) thick paste, juice and fine powder mixing above-mentioned steps (1) obtained to (4), it is the thick paste of 1.20-1.24 that heating is condensed into relative density at 60 DEG C, dry, pulverize as 16-18 order granule, add carboxymethylstach sodium in mass ratio, mannitol, crosslinked polyethylene pyrrole alkane ketone, magnesium stearate, sodium alginate stir, be compressed to tablet.
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| CN104474108A (en) * | 2014-12-11 | 2015-04-01 | 吕桂兰 | Traditional Chinese medicine preparation for treating acute appendicitis and preparation method of traditional Chinese medicine preparation |
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| CN104257805A (en) * | 2014-09-26 | 2015-01-07 | 史玉占 | Pharmaceutical composition for treating acute appendicitis |
| CN104474108A (en) * | 2014-12-11 | 2015-04-01 | 吕桂兰 | Traditional Chinese medicine preparation for treating acute appendicitis and preparation method of traditional Chinese medicine preparation |
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| CN106389537A (en) * | 2016-06-27 | 2017-02-15 | 上海交通大学 | Traditional Chinese medicinal composition for treating lung-heat cough |
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