CN106466442A - A kind of Radix achyranthis asperae (Herba Achyranthis Asperae) clearing away heat and expelling pathogen in the exterior bath effervescent tablets and preparation method thereof - Google Patents
A kind of Radix achyranthis asperae (Herba Achyranthis Asperae) clearing away heat and expelling pathogen in the exterior bath effervescent tablets and preparation method thereof Download PDFInfo
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- CN106466442A CN106466442A CN201510513477.4A CN201510513477A CN106466442A CN 106466442 A CN106466442 A CN 106466442A CN 201510513477 A CN201510513477 A CN 201510513477A CN 106466442 A CN106466442 A CN 106466442A
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Abstract
A kind of Radix achyranthis asperae (Herba Achyranthis Asperae) clearing away heat and expelling pathogen in the exterior bath effervescent tablets and preparation method thereof, it is made up by following percentage by weight of raw material, Chinese medicine extract 20-35%, sour agent 10-20%, alkaline agent 10-20%, filler 30-50%, binding agent 1-10%, lubricant 1-10%, aromatic 0.1-1%；Raw materials by weight portion in described Chinese medicine extract, Radix achyranthis asperae (Herba Achyranthis Asperae) 50-70 part, Pericarpium Granati 15-20 part, Flos dolichoris 15-20 part, Styrax 8-12 part, Rhizoma Polygoni Cuspidati 8-12 part, Receptaculum Nelumbiniss 5-8 part, Radix Scutellariae 5-8 part, Herba Chrysopogonis Aciculati 5-8 part, Radix Sanguisorbae 5-8 part, Lignum Sappan 5-8 part, the mainly comprising the following steps of preparation method：Step 1, prepare Chinese medicine extract：Clean, remove impurity, mixing, extraction；Step 2, mixing：Prepare acid particles, prepare alkali grain, mixing, tabletting.A kind of Radix achyranthis asperae (Herba Achyranthis Asperae) clearing away heat and expelling pathogen in the exterior bath effervescent tablets of the present invention, life-time service has functions that clearing away heat and expelling pathogen in the exterior, diuretic, promoting blood circulation.
Description
Technical field
The present invention relates to a kind of health body-wash articles for use, particularly a kind of Radix achyranthis asperae (Herba Achyranthis Asperae) clearing away heat and expelling pathogen in the exterior bath effervescent tablets and preparation method thereof.
Background technology
In the traditional Chinese medical science, dipping method is one of external treatment, that is, use medicinal liquid or a kind of method containing medicinal liquid water washing bath whole body or local, and its form is varied：Have full bath and claim " liquid medicine bath "；The title again having " scalding ", " fumigation and wash method ", " demibain ", " foot bath " etc. of local bathing, especially scalds the most commonly used.
Chinese dipping, have existed since ancient times.Earliest hospital of China<52 Bingfang>In just have the dipping side controlling baby's epilepsy.《Book of Rites》In say " head has skin ulcer then to wash one's hair, and body has infectionss then to bathe ",《Huang di's Canon of Medicine》In have the record of " its be subject to exopathogen person, bathing the body with hot decoction to induce diaphoresis ", can say, the history of dipping is of long standing and well established, be laid a foundation in the Qin Dynasty, be developed in Chinese Tang, enrich in Song Ming, ripe in the Qing Dynasty.
The common dipping species in current market is broadly divided into three classes, including：Full bath, demibain, foot bath, using method is also very simply it is only necessary in the liquid medicine having dissolved to the bidet entering to mix up water temperature and the water yield or bath bucket, then steep body in water；Client progressively can experience the change of body generation during bathing.
The dipping mechanism of action in general, be medicine act on whole body flesh table, locally, affected part, and through absorb, circulation meridians blood vessels, inside reach internal organs, from outward appearance to inner essence, thus produce effect.Dipping bathing, can play dredging the meridian, activating blood circulation to dissipate blood stasis, wind dispelling cold expelling, heat-clearing and toxic substances removing, reducing swelling and alleviating pain, regulating YIN and YANG, coordinate internal organs, current QI and blood, moisten the health maintenance effect such as foster whole body.Modern pharmacology also confirms that, can improve the content of some immunoglobulins in blood after dipping, strengthens elasticity and the vigor of skin.
Medicine used by dipping on market mostly is medicinal liquid or medicated powder, medicinal liquid or medicated powder is not portable, and composition easily runs off, and medicinal liquid that most of Chinese herbal medicine process or medicated powder cannot the sufficiently effective effective ingredient playing Chinese crude drug, loss or the waste of drug effect can be caused, and be prepared into effervescent tablet and be then easy to preserve and carry, dissolution velocity is fast, bioavailability is high, can improve clinical efficacy.
At present, the medicine of clearing away heat and expelling pathogen in the exterior or health product have much on market, but the effect of most drug is not very well, and the side effect of most drug is more, and health can be damaged, and therefore, market is badly in need of a kind of
Radix achyranthis asperae (Herba Achyranthis Asperae) clearing away heat and expelling pathogen in the exterior bath effervescent tablets and preparation method thereof.
Content of the invention
It is an object of the invention to provide a kind of Radix achyranthis asperae (Herba Achyranthis Asperae) clearing away heat and expelling pathogen in the exterior bath effervescent tablets and preparation method thereof, life-time service has clearing away heat and expelling pathogen in the exterior, diuretic, the effect of promoting blood circulation.
The purpose of the present invention is achieved through the following technical solutions：
A kind of Radix achyranthis asperae (Herba Achyranthis Asperae) clearing away heat and expelling pathogen in the exterior bath effervescent tablets and preparation method thereof, it is made up by following percentage by weight of raw material, Chinese medicine extract 20-35%, sour agent 10-20%, alkaline agent 10-20%, filler 30-50%, binding agent 1-10%, lubricant 1-10%, aromatic 0.1-1%；Raw materials by weight portion in described Chinese medicine extract, Radix achyranthis asperae (Herba Achyranthis Asperae) 50-70 part, Pericarpium Granati 15-20 part, Flos dolichoris 15-20 part, Styrax 8-12 part, Rhizoma Polygoni Cuspidati 8-12 part, Receptaculum Nelumbiniss 5-8 part, Radix Scutellariae 5-8 part, Herba Chrysopogonis Aciculati 5-8 part, Radix Sanguisorbae 5-8 part, Lignum Sappan 5-8 part.
In described Chinese medicine extract, raw material presses optimum weight number, 60 parts of Radix achyranthis asperae (Herba Achyranthis Asperae), 18 parts of Pericarpium Granati, 17 parts of Flos dolichoris, 12 parts of Styrax, 10 parts of Rhizoma Polygoni Cuspidati, 8 parts of Receptaculum Nelumbiniss, 7 parts of Radix Scutellariae, 6 parts of Herba Chrysopogonis Aciculati, 5 parts of Radix Sanguisorbae, 5 parts of Lignum Sappan.
Described sour agent is citric acid or tartaric acid or citric acid or fumaric acid.
Described alkaline agent is sodium carbonate or sodium bicarbonate.
Described filler is Microcrystalline Cellulose, sucrose, Lactose, sodium chloride, the calcium sulfate mixing of one or more therein.
Described binding agent is starch slurry or Microcrystalline Cellulose.
Described lubricant is the mixing of one of magnesium stearate, sodium lauryl sulphate or two kinds.
Described a kind of Radix achyranthis asperae (Herba Achyranthis Asperae) clearing away heat and expelling pathogen in the exterior bath effervescent tablets and preparation method thereof, the mainly comprising the following steps of its preparation method：
Step 1, prepare Chinese medicine extract：
a
, by weight, the Radix achyranthis asperae (Herba Achyranthis Asperae) of selection high-quality, Pericarpium Granati, Flos dolichoris, Styrax, Rhizoma Polygoni Cuspidati, Receptaculum Nelumbiniss, Radix Scutellariae, Herba Chrysopogonis Aciculati, Radix Sanguisorbae, Lignum Sappan, clean and remove impurity, mix homogeneously after remove impurity, add water to cook three times, the water small fire adding 12-15 times for the first time decocts 90-120 minute, filters, and extracts filtrate, second plus 10-12 times of water moderate heat decocts 60-90 minute, filter, extract filtrate, the water big fire that third time adds 6-8 times decocts 30-45 minute, filter, extract filtrate, mix three filtrates, obtain mixed extract；
b
, mixed extract is concentrated, be dried using spray dryer after concentration, obtain solid mixed extract, pulverized 60-80 mesh sieve, and obtained solid particle；
Step 2, mixing：
a
, the solid particle obtaining in step 1 is divided into uniform two parts, choose sour agent, alkaline agent, filler, binding agent, carry out respectively pulverizing 60 mesh sieves；
b
, first part of solid particle add the sour agent after pulverizing, filler, binding agent; it is then placed in trough type mixing machine; open trough type mixing machine to mix 30 minutes, add the PVP K30 ethanol solution that concentration is 1%, soft material processed into trough type mixing machine; add to soft material moderate after; soft material is put in oscillating granulator, makes granule, 60 eye mesh screen on oscillating granulator; dry, obtain acid particles；
c
, second part
Solid particle adds the alkaline agent after pulverizing, filler, binding agent; it is then placed in trough type mixing machine; open trough type mixing machine to mix 30 minutes, add the PVP K30 ethanol solution that concentration is 1%, soft material processed into trough type mixing machine; add to soft material moderate after; soft material is put in oscillating granulator, makes granule, 60 eye mesh screen on oscillating granulator; dry, obtain alkali grain；
d
, by acid particles, alkali grain, lubricant, aromatic mixing, put into tabletting in automatic tableting press after fully mixing, aluminum-plastic packaged, obtain a kind of Radix achyranthis asperae (Herba Achyranthis Asperae) clearing away heat and expelling pathogen in the exterior bath effervescent tablets.
In medicine：Radix achyranthis asperae (Herba Achyranthis Asperae) heat clearing away, induces sweat, diuretic, promoting blood circulation, and cure cold heating, dysentery, malaria, laryngalgia, tinea pedis, gonorrhea, edema, traumatic injury；Pericarpium Granati relieving diarrhea with astringents, hemostasis, anthelmintic；For chronic diarrhea, chronic dysentery, have blood in stool, proctoptosis, metrorrhagia, leucorrhea, abdominal pain due to worm stagnation；Flos dolichoris invigorating the spleen and regulating the stomach, removing dampness of relieving summer heat；Control dysentery, have loose bowels, leucorrhea with red and white discharge；Styrax is opened surreptitiously, wards off dirty, pain relieving；For apoplexy syncope due to accumulation of phlegm, suddenly faint, chest and abdomen cold type of pain, infantile convulsion；Rhizoma Polygoni Cuspidati expelling wind and removing dampness, scattered stasis pain, relieving cough and resolving phlegm；For arthralgia, jaundice due to damp-heat, amenorrhea, lump in the abdomen, burn due to hot liquid or fire, injury from falling down, carbuncle sore tumefacting virus, cough with copious phlegm；Receptaculum Nelumbiniss repercussive stops blooding；Main metrorrhagia；Menorrhagia；Have blood in stool；Hematuria；Radix Scutellariae removing the relative excess fire, except damp and hot, hemostasis, antiabortive；Control high fever excessive thirst, cough due to lung-heat, damp-heat dysentery, jaundice, pyretic stranguria, tell, be defeated in battle, collapse, leak, conjunctival congestion and swelling pain, frequent fetal movement, carbuncle swells furunculosis；Herba Chrysopogonis Aciculati clearing away heat-damp and promoting diuresis；For upper respiratory tract infection, acute gastroenteritiss, summer-heat oliguria with reddish urine；Radix Sanguisorbae cooling blood for hemostasis, removing toxic substances sore, it is used for having blood in stool, hemorrhoidal bleeding, dysentery, metrorrhagia, burn due to hot liquid or fire, carbuncle sore tumefacting virus；Lignum Sappan promoting the circulation of blood blood stasis dispelling, reducing swelling and alleviating pain, for closed dysmenorrhea, postpartum stagnation, chest and abdomen shouting pain, wound swells and ache
.
Beneficial effects of the present invention：One kind of the present invention
Radix achyranthis asperae (Herba Achyranthis Asperae) clearing away heat and expelling pathogen in the exterior bath effervescent tablets, to cold, fever, dysentery etc.
Main
Disease
Card serves to varying degrees
Clearing away heat and expelling pathogen in the exterior, diuretic, promoting blood circulation
Effect,
There are health care, instant effect, pure natural, no side effectses.
The present invention uses the present invention through two groups of clinical verifications, one of which for treatment group, uses the present invention once daily, is within 7 days a course for the treatment of, and another group of matched group is taken
QINGRE JIEDU KOUFUYE
, daily using once, being within 7 days a course for the treatment of, every group selection outpatient 110, wherein man 55, female 55, max age 75 years old, minimal ages 20 years old, clinical manifestation is cold, fever, dysentery, malaria, laryngalgia, tinea pedis, gonorrhea
, table one is the contrasting data after taking a course for the treatment of：
Table 1 is taken two groups of courses for the treatment of of before and after and is compared (unit:People)
There were significant differences for treatment group and matched group, it will thus be seen that present invention application clinically has significant curative effect.
Specific embodiment
Embodiment 1
A kind of Radix achyranthis asperae (Herba Achyranthis Asperae) clearing away heat and expelling pathogen in the exterior bath effervescent tablets and preparation method thereof, it is made up by following percentage by weight of raw material, Chinese medicine extract 20-35%, sour agent 10-20%, alkaline agent 10-20%, filler 30-50%, binding agent 1-10%, lubricant 1-10%, aromatic 0.1-1%；Raw materials by weight portion in described Chinese medicine extract, Radix achyranthis asperae (Herba Achyranthis Asperae) 50-70 part, Pericarpium Granati 15-20 part, Flos dolichoris 15-20 part, Styrax 8-12 part, Rhizoma Polygoni Cuspidati 8-12 part, Receptaculum Nelumbiniss 5-8 part, Radix Scutellariae 5-8 part, Herba Chrysopogonis Aciculati 5-8 part, Radix Sanguisorbae 5-8 part, Lignum Sappan 5-8 part.
In described Chinese medicine extract, raw material presses optimum weight number, 60 parts of Radix achyranthis asperae (Herba Achyranthis Asperae), 18 parts of Pericarpium Granati, 17 parts of Flos dolichoris, 12 parts of Styrax, 10 parts of Rhizoma Polygoni Cuspidati, 8 parts of Receptaculum Nelumbiniss, 7 parts of Radix Scutellariae, 6 parts of Herba Chrysopogonis Aciculati, 5 parts of Radix Sanguisorbae, 5 parts of Lignum Sappan.
Described sour agent is citric acid or tartaric acid or citric acid or fumaric acid.
Described alkaline agent is sodium carbonate or sodium bicarbonate.
Described filler is Microcrystalline Cellulose, sucrose, Lactose, sodium chloride, the calcium sulfate mixing of one or more therein.
Described binding agent is starch slurry or Microcrystalline Cellulose.
Described lubricant is the mixing of one of magnesium stearate, sodium lauryl sulphate or two kinds.
Described a kind of Radix achyranthis asperae (Herba Achyranthis Asperae) clearing away heat and expelling pathogen in the exterior bath effervescent tablets and preparation method thereof, the mainly comprising the following steps of its preparation method：
Step 1, prepare Chinese medicine extract：
a
, by weight, the Radix achyranthis asperae (Herba Achyranthis Asperae) of selection high-quality, Pericarpium Granati, Flos dolichoris, Styrax, Rhizoma Polygoni Cuspidati, Receptaculum Nelumbiniss, Radix Scutellariae, Herba Chrysopogonis Aciculati, Radix Sanguisorbae, Lignum Sappan, clean and remove impurity, mix homogeneously after remove impurity, add water to cook three times, the water small fire adding 12-15 times for the first time decocts 90-120 minute, filters, and extracts filtrate, second plus 10-12 times of water moderate heat decocts 60-90 minute, filter, extract filtrate, the water big fire that third time adds 6-8 times decocts 30-45 minute, filter, extract filtrate, mix three filtrates, obtain mixed extract；
b
, mixed extract is concentrated, be dried using spray dryer after concentration, obtain solid mixed extract, pulverized 60-80 mesh sieve, and obtained solid particle；
Step 2, mixing：
a
, the solid particle obtaining in step 1 is divided into uniform two parts, choose sour agent, alkaline agent, filler, binding agent, carry out respectively pulverizing 60 mesh sieves；
b
, first part of solid particle add the sour agent after pulverizing, filler, binding agent; it is then placed in trough type mixing machine; open trough type mixing machine to mix 30 minutes, add the PVP K30 ethanol solution that concentration is 1%, soft material processed into trough type mixing machine; add to soft material moderate after; soft material is put in oscillating granulator, makes granule, 60 eye mesh screen on oscillating granulator; dry, obtain acid particles；
c
, second part
Solid particle adds the alkaline agent after pulverizing, filler, binding agent; it is then placed in trough type mixing machine; open trough type mixing machine to mix 30 minutes, add the PVP K30 ethanol solution that concentration is 1%, soft material processed into trough type mixing machine; add to soft material moderate after; soft material is put in oscillating granulator, makes granule, 60 eye mesh screen on oscillating granulator; dry, obtain alkali grain；
d
, by acid particles, alkali grain, lubricant, aromatic mixing, put into tabletting in automatic tableting press after fully mixing, aluminum-plastic packaged, obtain a kind of Radix achyranthis asperae (Herba Achyranthis Asperae) clearing away heat and expelling pathogen in the exterior bath effervescent tablets.
Claims (8)
1. a kind of Radix achyranthis asperae (Herba Achyranthis Asperae) clearing away heat and expelling pathogen in the exterior bath effervescent tablets it is characterised in that：It is made up by following percentage by weight of raw material, Chinese medicine extract 20-35%, sour agent 10-20%, alkaline agent 10-20%, filler 30-50%, binding agent 1-10%, lubricant 1-10%, aromatic 0.1-1%；Raw materials by weight portion in described Chinese medicine extract, Radix achyranthis asperae (Herba Achyranthis Asperae) 50-70 part, Pericarpium Granati 15-20 part, Flos dolichoris 15-20 part, Styrax 8-12 part, Rhizoma Polygoni Cuspidati 8-12 part, Receptaculum Nelumbiniss 5-8 part, Radix Scutellariae 5-8 part, Herba Chrysopogonis Aciculati 5-8 part, Radix Sanguisorbae 5-8 part, Lignum Sappan 5-8 part.
2. a kind of Radix achyranthis asperae (Herba Achyranthis Asperae) clearing away heat and expelling pathogen in the exterior bath effervescent tablets according to claim 1 it is characterised in that：In described Chinese medicine extract, raw material presses optimum weight number, 60 parts of Radix achyranthis asperae (Herba Achyranthis Asperae), 18 parts of Pericarpium Granati, 17 parts of Flos dolichoris, 12 parts of Styrax, 10 parts of Rhizoma Polygoni Cuspidati, 8 parts of Receptaculum Nelumbiniss, 7 parts of Radix Scutellariae, 6 parts of Herba Chrysopogonis Aciculati, 5 parts of Radix Sanguisorbae, 5 parts of Lignum Sappan.
3. a kind of Radix achyranthis asperae (Herba Achyranthis Asperae) clearing away heat and expelling pathogen in the exterior bath effervescent tablets according to claim 1 it is characterised in that：Described sour agent is citric acid or tartaric acid or citric acid or fumaric acid.
4. a kind of Radix achyranthis asperae (Herba Achyranthis Asperae) clearing away heat and expelling pathogen in the exterior bath effervescent tablets according to claim 1 it is characterised in that：Described alkaline agent is sodium carbonate or sodium bicarbonate.
5. a kind of Radix achyranthis asperae (Herba Achyranthis Asperae) clearing away heat and expelling pathogen in the exterior bath effervescent tablets according to claim 1 it is characterised in that：Described filler is Microcrystalline Cellulose, sucrose, Lactose, sodium chloride, the calcium sulfate mixing of one or more therein.
6. a kind of Radix achyranthis asperae (Herba Achyranthis Asperae) clearing away heat and expelling pathogen in the exterior bath effervescent tablets according to claim 1 it is characterised in that：Described binding agent is starch slurry or Microcrystalline Cellulose.
7. a kind of Radix achyranthis asperae (Herba Achyranthis Asperae) clearing away heat and expelling pathogen in the exterior bath effervescent tablets according to claim 1 it is characterised in that：Described lubricant is the mixing of one of magnesium stearate, sodium lauryl sulphate or two kinds.
8. a kind of Radix achyranthis asperae (Herba Achyranthis Asperae) clearing away heat and expelling pathogen in the exterior bath effervescent tablets according to claim 1-7 and preparation method thereof it is characterised in that：The mainly comprising the following steps of its preparation method：
Step 1, prepare Chinese medicine extract：
A, by weight, the Radix achyranthis asperae (Herba Achyranthis Asperae) of selection high-quality, Pericarpium Granati, Flos dolichoris, Styrax, Rhizoma Polygoni Cuspidati, Receptaculum Nelumbiniss, Radix Scutellariae, Herba Chrysopogonis Aciculati, Radix Sanguisorbae, Lignum Sappan, clean and remove impurity, mix homogeneously after remove impurity, add water to cook three times, the water small fire adding 12-15 times for the first time decocts 90-120 minute, filters, and extracts filtrate, second plus 10-12 times of water moderate heat decocts 60-90 minute, filter, extract filtrate, the water big fire that third time adds 6-8 times decocts 30-45 minute, filter, extract filtrate, mix three filtrates, obtain mixed extract；
B, mixed extract is concentrated, be dried using spray dryer after concentration, obtain solid mixed extract, pulverized 60-80 mesh sieve, and obtained solid particle；
Step 2, mixing：
A, the solid particle obtaining in step 1 is divided into uniform two parts, chooses sour agent, alkaline agent, filler, binding agent, carry out respectively pulverizing 60 mesh sieves；
B, first part of solid particle add the sour agent after pulverizing, filler, binding agent; it is then placed in trough type mixing machine; open trough type mixing machine to mix 30 minutes, add the PVP K30 ethanol solution that concentration is 1%, soft material processed into trough type mixing machine; add to soft material moderate after; soft material is put in oscillating granulator, makes granule, 60 eye mesh screen on oscillating granulator; dry, obtain acid particles；
C, second part of solid particle add the alkaline agent after pulverizing, filler, binding agent; it is then placed in trough type mixing machine; open trough type mixing machine to mix 30 minutes, add the PVP K30 ethanol solution that concentration is 1%, soft material processed into trough type mixing machine; add to soft material moderate after; soft material is put in oscillating granulator, makes granule, 60 eye mesh screen on oscillating granulator; dry, obtain alkali grain；
D, by acid particles, alkali grain, lubricant, aromatic mixing, put into tabletting in automatic tableting press after fully mixing, aluminum-plastic packaged, obtain a kind of Radix achyranthis asperae (Herba Achyranthis Asperae) clearing away heat and expelling pathogen in the exterior bath effervescent tablets.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510513477.4A CN106466442A (en) | 2015-08-20 | 2015-08-20 | A kind of Radix achyranthis asperae (Herba Achyranthis Asperae) clearing away heat and expelling pathogen in the exterior bath effervescent tablets and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510513477.4A CN106466442A (en) | 2015-08-20 | 2015-08-20 | A kind of Radix achyranthis asperae (Herba Achyranthis Asperae) clearing away heat and expelling pathogen in the exterior bath effervescent tablets and preparation method thereof |
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| Publication Number | Publication Date |
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| CN106466442A true CN106466442A (en) | 2017-03-01 |
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