CN106466451A - A kind of Herba Sedi Bulbiferi cold expelling bath effervescent tablets and preparation method thereof - Google Patents
A kind of Herba Sedi Bulbiferi cold expelling bath effervescent tablets and preparation method thereof Download PDFInfo
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- CN106466451A CN106466451A CN201510513436.5A CN201510513436A CN106466451A CN 106466451 A CN106466451 A CN 106466451A CN 201510513436 A CN201510513436 A CN 201510513436A CN 106466451 A CN106466451 A CN 106466451A
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Abstract
A kind of Herba Sedi Bulbiferi cold expelling bath effervescent tablets and preparation method thereof, it is made up by following percentage by weight of raw material, Chinese medicine extract 20-35%, sour agent 10-20%, alkaline agent 10-20%, filler 30-50%, binding agent 1-10%, lubricant 1-10%, aromatic 0.1-1%；Raw materials by weight portion in described Chinese medicine extract, Herba Sedi Bulbiferi 50-70 part, Auricularia Sophorae 15-20 part, Cortex sophorae 15-20 part, Cortex betulae platyphyllae 8-12 part, Testa arachidis hypogaeae 8-12 part, Radix Diospyroris foochowensiss 5-8 part, Rhizoma Sparganii 5-8 part, Radix cocculi trilobi 5-8 part, Radix seu cortex hberberidis heteropodae 5-8 part, Plantula Excoecariae Acerifoliae 5-8 part, the mainly comprising the following steps of preparation method：Step 1, prepare Chinese medicine extract：Clean, remove impurity, mixing, extraction；Step 2, mixing：Prepare acid particles, prepare alkali grain, mixing, tabletting.A kind of Herba Sedi Bulbiferi cold expelling bath effervescent tablets of the present invention, life-time service has functions that cold expelling, qi-regulating, hemostasis.
Description
Technical field
The present invention relates to a kind of health body-wash articles for use, particularly a kind of Herba Sedi Bulbiferi cold expelling bath effervescent tablets and preparation method thereof.
Background technology
In the traditional Chinese medical science, dipping method is one of external treatment, that is, use medicinal liquid or a kind of method containing medicinal liquid water washing bath whole body or local, and its form is varied：Have full bath and claim " liquid medicine bath "；The title again having " scalding ", " fumigation and wash method ", " demibain ", " foot bath " etc. of local bathing, especially scalds the most commonly used.
Chinese dipping, have existed since ancient times.Earliest hospital of China<52 Bingfang>In just have the dipping side controlling baby's epilepsy.《Book of Rites》In say " head has skin ulcer then to wash one's hair, and body has infectionss then to bathe ",《Huang di's Canon of Medicine》In have the record of " its be subject to exopathogen person, bathing the body with hot decoction to induce diaphoresis ", can say, the history of dipping is of long standing and well established, be laid a foundation in the Qin Dynasty, be developed in Chinese Tang, enrich in Song Ming, ripe in the Qing Dynasty.
The common dipping species in current market is broadly divided into three classes, including：Full bath, demibain, foot bath, using method is also very simply it is only necessary in the liquid medicine having dissolved to the bidet entering to mix up water temperature and the water yield or bath bucket, then steep body in water；Client progressively can experience the change of body generation during bathing.
The dipping mechanism of action in general, be medicine act on whole body flesh table, locally, affected part, and through absorb, circulation meridians blood vessels, inside reach internal organs, from outward appearance to inner essence, thus produce effect.Dipping bathing, can play dredging the meridian, activating blood circulation to dissipate blood stasis, wind dispelling cold expelling, heat-clearing and toxic substances removing, reducing swelling and alleviating pain, regulating YIN and YANG, coordinate internal organs, current QI and blood, moisten the health maintenance effect such as foster whole body.Modern pharmacology also confirms that, can improve the content of some immunoglobulins in blood after dipping, strengthens elasticity and the vigor of skin.
Medicine used by dipping on market mostly is medicinal liquid or medicated powder, medicinal liquid or medicated powder is not portable, and composition easily runs off, and medicinal liquid that most of Chinese herbal medicine process or medicated powder cannot the sufficiently effective effective ingredient playing Chinese crude drug, loss or the waste of drug effect can be caused, and be prepared into effervescent tablet and be then easy to preserve and carry, dissolution velocity is fast, bioavailability is high, can improve clinical efficacy.
At present, the medicine of cold expelling or health product have much on market, but the effect of most drug is not very well, and the side effect of most drug is more, and health can be damaged, and therefore, market is badly in need of a kind of
Herba Sedi Bulbiferi cold expelling bath effervescent tablets and preparation method thereof.
Content of the invention
It is an object of the invention to provide a kind of Herba Sedi Bulbiferi cold expelling bath effervescent tablets and preparation method thereof, life-time service has cold expelling, qi-regulating, the effect of hemostasis.
The purpose of the present invention is achieved through the following technical solutions：
A kind of Herba Sedi Bulbiferi cold expelling bath effervescent tablets and preparation method thereof, it is made up by following percentage by weight of raw material, Chinese medicine extract 20-35%, sour agent 10-20%, alkaline agent 10-20%, filler 30-50%, binding agent 1-10%, lubricant 1-10%, aromatic 0.1-1%；Raw materials by weight portion in described Chinese medicine extract, Herba Sedi Bulbiferi 50-70 part, Auricularia Sophorae 15-20 part, Cortex sophorae 15-20 part, Cortex betulae platyphyllae 8-12 part, Testa arachidis hypogaeae 8-12 part, Radix Diospyroris foochowensiss 5-8 part, Rhizoma Sparganii 5-8 part, Radix cocculi trilobi 5-8 part, Radix seu cortex hberberidis heteropodae 5-8 part, Plantula Excoecariae Acerifoliae 5-8 part.
In described Chinese medicine extract, raw material presses optimum weight number, 60 parts of Herba Sedi Bulbiferi, 18 parts of Auricularia Sophorae, 17 parts of Cortex sophorae, 12 parts of Cortex betulae platyphyllae, 10 parts of Testa arachidis hypogaeae, 8 parts of Radix Diospyroris foochowensiss, 7 parts of Rhizoma Sparganii, 6 parts of Radix cocculi trilobi, 5 parts of Radix seu cortex hberberidis heteropodae, 5 parts of Plantula Excoecariae Acerifoliae.
Described sour agent is citric acid or tartaric acid or citric acid or fumaric acid.
Described alkaline agent is sodium carbonate or sodium bicarbonate.
Described filler is Microcrystalline Cellulose, sucrose, Lactose, sodium chloride, the calcium sulfate mixing of one or more therein.
Described binding agent is starch slurry or Microcrystalline Cellulose.
Described lubricant is the mixing of one of magnesium stearate, sodium lauryl sulphate or two kinds.
Described a kind of Herba Sedi Bulbiferi cold expelling bath effervescent tablets and preparation method thereof, the mainly comprising the following steps of its preparation method：
Step 1, prepare Chinese medicine extract：
a
, by weight, the Herba Sedi Bulbiferi of selection high-quality, Auricularia Sophorae, Cortex sophorae, Cortex betulae platyphyllae, Testa arachidis hypogaeae, Radix Diospyroris foochowensiss, Rhizoma Sparganii, Radix cocculi trilobi, Radix seu cortex hberberidis heteropodae, Plantula Excoecariae Acerifoliae, clean and remove impurity, mix homogeneously after remove impurity, add water to cook three times, the water small fire adding 12-15 times for the first time decocts 90-120 minute, filters, and extracts filtrate, second plus 10-12 times of water moderate heat decocts 60-90 minute, filter, extract filtrate, the water big fire that third time adds 6-8 times decocts 30-45 minute, filter, extract filtrate, mix three filtrates, obtain mixed extract；
b
, mixed extract is concentrated, be dried using spray dryer after concentration, obtain solid mixed extract, pulverized 60-80 mesh sieve, and obtained solid particle；
Step 2, mixing：
a
, the solid particle obtaining in step 1 is divided into uniform two parts, choose sour agent, alkaline agent, filler, binding agent, carry out respectively pulverizing 60 mesh sieves；
b
, first part of solid particle add the sour agent after pulverizing, filler, binding agent; it is then placed in trough type mixing machine; open trough type mixing machine to mix 30 minutes, add the PVP K30 ethanol solution that concentration is 1%, soft material processed into trough type mixing machine; add to soft material moderate after; soft material is put in oscillating granulator, makes granule, 60 eye mesh screen on oscillating granulator; dry, obtain acid particles；
c
, second part
Solid particle adds the alkaline agent after pulverizing, filler, binding agent; it is then placed in trough type mixing machine; open trough type mixing machine to mix 30 minutes, add the PVP K30 ethanol solution that concentration is 1%, soft material processed into trough type mixing machine; add to soft material moderate after; soft material is put in oscillating granulator, makes granule, 60 eye mesh screen on oscillating granulator; dry, obtain alkali grain；
d
, by acid particles, alkali grain, lubricant, aromatic mixing, put into tabletting in automatic tableting press after fully mixing, aluminum-plastic packaged, obtain a kind of Herba Sedi Bulbiferi cold expelling bath effervescent tablets.
In medicine：Herba Sedi Bulbiferi cold expelling, qi-regulating, control cold and heat malaria, abdominal pain due to retention of food, rheumatism paralysis and pestilence dermexanthesis；Auricularia Sophorae stops blooding；Dysentery relieving；Anticancer；Main bleeding hemorrhoidss；Have blood in stool；Metrorrhagia；Dysentery；Hepatocarcinoma；Hepatitis；Cortex sophorae expelling wind and removing dampness, reducing swelling and alleviating pain；In controlling outside ailment said due to cold or exposure, orthotonus, numbness of the skin, calentura aphtha, ulcerative gingivitis, sore throat, discharging fresh blood stool, cellulitis, hemorrhoid, rotten sore, pudendum is itched bitterly, soup, burning hot wound；Cortex betulae platyphyllae clearing away heat-damp and promoting diuresis；Expelling phlegm for arresting cough；Removing toxic substances；Main pharyngalgia sore throat；Cough and asthma；Jaundice；Diarrhoea；Dysentery；Stranguria；Dysuria；Acute mastitis；Sore；Prurigo；Testa arachidis hypogaeae hemostasis, dissipating blood stasis, detumescence；For hemophilia, hemophilioid disease, constitutional and secondary thrombocytopenic purpura, hepatopathy hemorrhage, postoperative hemorrhage, cancerous protuberance bleeding, the bleeding such as stomach, intestinal, lung, uterus；Radix Diospyroris foochowensiss heat clearing away, removing heat from blood, stimulate the menstrual flow, diuretic, control cough due to lung-heat, spit blood, discharging fresh blood stool, stop over, tympanites；Rhizoma Sparganii blood-breaking, Xiao Ji Zhi Tong, for abdominal mass lump in the abdomen, blood stasis closed, food stagnation distending pain；Radix cocculi trilobi expelling wind and removing dampness, removing toxic substances and promoting subsidence of swelling, control acute filthy disease stomachache, rheumatic arthritis, hemiplegia, oedema due to nephritis, urinary tract infection, furuncle, eczema, innominate toxic swelling；Radix seu cortex hberberidis heteropodae heat clearing and damp drying, eliminating fire and detoxication, control dysentery, enteritis, pharyngitis, stomatitis, eczema, furuncle and phyma；Plantula Excoecariae Acerifoliae circulation of qi promoting；Removing blood stasis；Removing food stagnancy；Malaria；Primary symptom abdominal mass；Food stagnation；Tympanites；Jaundice；Malaria
.
Beneficial effects of the present invention：One kind of the present invention
Herba Sedi Bulbiferi cold expelling bath effervescent tablets, to cold and heat malaria, abdominal pain due to retention of food etc.
Main
Disease
Card serves to varying degrees
Cold expelling, qi-regulating, hemostasis
Effect,
There are health care, instant effect, pure natural, no side effectses.
The present invention uses the present invention through two groups of clinical verifications, one of which for treatment group, uses the present invention once daily, is within 7 days a course for the treatment of, and another group of matched group is taken
Flos Nelumbinis clear pestilence capsule
, daily using once, being within 7 days a course for the treatment of, every group selection outpatient 110, wherein man 55, female 55, max age 85 years old, minimal ages 35 years old, clinical manifestation is cold and heat malaria, abdominal pain due to retention of food, and rheumatism is paralysed, and pestilence dermexanthesis is had blood in stool, metrorrhagia
, table one is the contrasting data after taking a course for the treatment of：
Table 1 is taken two groups of courses for the treatment of of before and after and is compared (unit:People)
There were significant differences for treatment group and matched group, it will thus be seen that present invention application clinically has significant curative effect.
Specific embodiment
Embodiment 1
A kind of Herba Sedi Bulbiferi cold expelling bath effervescent tablets and preparation method thereof, it is made up by following percentage by weight of raw material, Chinese medicine extract 20-35%, sour agent 10-20%, alkaline agent 10-20%, filler 30-50%, binding agent 1-10%, lubricant 1-10%, aromatic 0.1-1%；Raw materials by weight portion in described Chinese medicine extract, Herba Sedi Bulbiferi 50-70 part, Auricularia Sophorae 15-20 part, Cortex sophorae 15-20 part, Cortex betulae platyphyllae 8-12 part, Testa arachidis hypogaeae 8-12 part, Radix Diospyroris foochowensiss 5-8 part, Rhizoma Sparganii 5-8 part, Radix cocculi trilobi 5-8 part, Radix seu cortex hberberidis heteropodae 5-8 part, Plantula Excoecariae Acerifoliae 5-8 part.
In described Chinese medicine extract, raw material presses optimum weight number, 60 parts of Herba Sedi Bulbiferi, 18 parts of Auricularia Sophorae, 17 parts of Cortex sophorae, 12 parts of Cortex betulae platyphyllae, 10 parts of Testa arachidis hypogaeae, 8 parts of Radix Diospyroris foochowensiss, 7 parts of Rhizoma Sparganii, 6 parts of Radix cocculi trilobi, 5 parts of Radix seu cortex hberberidis heteropodae, 5 parts of Plantula Excoecariae Acerifoliae.
Described sour agent is citric acid or tartaric acid or citric acid or fumaric acid.
Described alkaline agent is sodium carbonate or sodium bicarbonate.
Described filler is Microcrystalline Cellulose, sucrose, Lactose, sodium chloride, the calcium sulfate mixing of one or more therein.
Described binding agent is starch slurry or Microcrystalline Cellulose.
Described lubricant is the mixing of one of magnesium stearate, sodium lauryl sulphate or two kinds.
Described a kind of Herba Sedi Bulbiferi cold expelling bath effervescent tablets and preparation method thereof, the mainly comprising the following steps of its preparation method：
Step 1, prepare Chinese medicine extract：
a
, by weight, the Herba Sedi Bulbiferi of selection high-quality, Auricularia Sophorae, Cortex sophorae, Cortex betulae platyphyllae, Testa arachidis hypogaeae, Radix Diospyroris foochowensiss, Rhizoma Sparganii, Radix cocculi trilobi, Radix seu cortex hberberidis heteropodae, Plantula Excoecariae Acerifoliae, clean and remove impurity, mix homogeneously after remove impurity, add water to cook three times, the water small fire adding 12-15 times for the first time decocts 90-120 minute, filters, and extracts filtrate, second plus 10-12 times of water moderate heat decocts 60-90 minute, filter, extract filtrate, the water big fire that third time adds 6-8 times decocts 30-45 minute, filter, extract filtrate, mix three filtrates, obtain mixed extract；
b
, mixed extract is concentrated, be dried using spray dryer after concentration, obtain solid mixed extract, pulverized 60-80 mesh sieve, and obtained solid particle；
Step 2, mixing：
a
, the solid particle obtaining in step 1 is divided into uniform two parts, choose sour agent, alkaline agent, filler, binding agent, carry out respectively pulverizing 60 mesh sieves；
b
, first part of solid particle add the sour agent after pulverizing, filler, binding agent; it is then placed in trough type mixing machine; open trough type mixing machine to mix 30 minutes, add the PVP K30 ethanol solution that concentration is 1%, soft material processed into trough type mixing machine; add to soft material moderate after; soft material is put in oscillating granulator, makes granule, 60 eye mesh screen on oscillating granulator; dry, obtain acid particles；
c
, second part
Solid particle adds the alkaline agent after pulverizing, filler, binding agent; it is then placed in trough type mixing machine; open trough type mixing machine to mix 30 minutes, add the PVP K30 ethanol solution that concentration is 1%, soft material processed into trough type mixing machine; add to soft material moderate after; soft material is put in oscillating granulator, makes granule, 60 eye mesh screen on oscillating granulator; dry, obtain alkali grain；
d
, by acid particles, alkali grain, lubricant, aromatic mixing, put into tabletting in automatic tableting press after fully mixing, aluminum-plastic packaged, obtain a kind of Herba Sedi Bulbiferi cold expelling bath effervescent tablets.
Claims (8)
1. a kind of Herba Sedi Bulbiferi cold expelling bath effervescent tablets it is characterised in that：It is made up by following percentage by weight of raw material, Chinese medicine extract 20-35%, sour agent 10-20%, alkaline agent 10-20%, filler 30-50%, binding agent 1-10%, lubricant 1-10%, aromatic 0.1-1%；Raw materials by weight portion in described Chinese medicine extract, Herba Sedi Bulbiferi 50-70 part, Auricularia Sophorae 15-20 part, Cortex sophorae 15-20 part, Cortex betulae platyphyllae 8-12 part, Testa arachidis hypogaeae 8-12 part, Radix Diospyroris foochowensiss 5-8 part, Rhizoma Sparganii 5-8 part, Radix cocculi trilobi 5-8 part, Radix seu cortex hberberidis heteropodae 5-8 part, Plantula Excoecariae Acerifoliae 5-8 part.
2. a kind of Herba Sedi Bulbiferi cold expelling bath effervescent tablets according to claim 1 it is characterised in that：In described Chinese medicine extract, raw material presses optimum weight number, 60 parts of Herba Sedi Bulbiferi, 18 parts of Auricularia Sophorae, 17 parts of Cortex sophorae, 12 parts of Cortex betulae platyphyllae, 10 parts of Testa arachidis hypogaeae, 8 parts of Radix Diospyroris foochowensiss, 7 parts of Rhizoma Sparganii, 6 parts of Radix cocculi trilobi, 5 parts of Radix seu cortex hberberidis heteropodae, 5 parts of Plantula Excoecariae Acerifoliae.
3. a kind of Herba Sedi Bulbiferi cold expelling bath effervescent tablets according to claim 1 it is characterised in that：Described sour agent is citric acid or tartaric acid or citric acid or fumaric acid.
4. a kind of Herba Sedi Bulbiferi cold expelling bath effervescent tablets according to claim 1 it is characterised in that：Described alkaline agent is sodium carbonate or sodium bicarbonate.
5. a kind of Herba Sedi Bulbiferi cold expelling bath effervescent tablets according to claim 1 it is characterised in that：Described filler is Microcrystalline Cellulose, sucrose, Lactose, sodium chloride, the calcium sulfate mixing of one or more therein.
6. a kind of Herba Sedi Bulbiferi cold expelling bath effervescent tablets according to claim 1 it is characterised in that：Described binding agent is starch slurry or Microcrystalline Cellulose.
7. a kind of Herba Sedi Bulbiferi cold expelling bath effervescent tablets according to claim 1 it is characterised in that：Described lubricant is the mixing of one of magnesium stearate, sodium lauryl sulphate or two kinds.
8. a kind of Herba Sedi Bulbiferi cold expelling bath effervescent tablets according to claim 1-7 and preparation method thereof it is characterised in that：The mainly comprising the following steps of its preparation method：
Step 1, prepare Chinese medicine extract：
A, by weight, the Herba Sedi Bulbiferi of selection high-quality, Auricularia Sophorae, Cortex sophorae, Cortex betulae platyphyllae, Testa arachidis hypogaeae, Radix Diospyroris foochowensiss, Rhizoma Sparganii, Radix cocculi trilobi, Radix seu cortex hberberidis heteropodae, Plantula Excoecariae Acerifoliae, clean and remove impurity, mix homogeneously after remove impurity, add water to cook three times, the water small fire adding 12-15 times for the first time decocts 90-120 minute, filters, and extracts filtrate, second plus 10-12 times of water moderate heat decocts 60-90 minute, filter, extract filtrate, the water big fire that third time adds 6-8 times decocts 30-45 minute, filter, extract filtrate, mix three filtrates, obtain mixed extract；
B, mixed extract is concentrated, be dried using spray dryer after concentration, obtain solid mixed extract, pulverized 60-80 mesh sieve, and obtained solid particle；
Step 2, mixing：
A, the solid particle obtaining in step 1 is divided into uniform two parts, chooses sour agent, alkaline agent, filler, binding agent, carry out respectively pulverizing 60 mesh sieves；
B, first part of solid particle add the sour agent after pulverizing, filler, binding agent; it is then placed in trough type mixing machine; open trough type mixing machine to mix 30 minutes, add the PVP K30 ethanol solution that concentration is 1%, soft material processed into trough type mixing machine; add to soft material moderate after; soft material is put in oscillating granulator, makes granule, 60 eye mesh screen on oscillating granulator; dry, obtain acid particles；
C, second part of solid particle add the alkaline agent after pulverizing, filler, binding agent; it is then placed in trough type mixing machine; open trough type mixing machine to mix 30 minutes, add the PVP K30 ethanol solution that concentration is 1%, soft material processed into trough type mixing machine; add to soft material moderate after; soft material is put in oscillating granulator, makes granule, 60 eye mesh screen on oscillating granulator; dry, obtain alkali grain；
D, by acid particles, alkali grain, lubricant, aromatic mixing, put into tabletting in automatic tableting press after fully mixing, aluminum-plastic packaged, obtain a kind of Herba Sedi Bulbiferi cold expelling bath effervescent tablets.
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|---|---|---|---|
| CN201510513436.5A CN106466451A (en) | 2015-08-20 | 2015-08-20 | A kind of Herba Sedi Bulbiferi cold expelling bath effervescent tablets and preparation method thereof |
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