CN106466440A - A kind of Anhydrite liver heat removing and eyesight improving bath effervescent tablets and preparation method thereof - Google Patents

Abstract

A kind of Anhydrite liver heat removing and eyesight improving bath effervescent tablets and preparation method thereof, it is made up by following percentage by weight of raw material, Chinese medicine extract 20-35%, sour agent 10-20%, alkaline agent 10-20%, filler 30-50%, binding agent 1-10%, lubricant 1-10%, aromatic 0.1-1%；Raw materials by weight portion in described Chinese medicine extract, Anhydrite 50-70 part, Herba Potentillae Chinensis 15-20 part, Radix seu herba Heteropogonis Contorti 15-20 part, Herba Saniculae lamelligerae 8-12 part, Herba Canscorae 8-12 part, Fructus Broussonetiae 5-8 part, brown sugar (Saccharum Sinensis Roxb.) 5-8 part, Herba Orobanchess 5-8 part, Asbestuss 5-8 part, fruit 5-8 part, the mainly comprising the following steps of preparation method：Step 1, prepare Chinese medicine extract：Clean, remove impurity, mixing, extraction；Step 2, mixing：Prepare acid particles, prepare alkali grain, mixing, tabletting.A kind of Anhydrite liver heat removing and eyesight improving bath effervescent tablets of the present invention, life-time service has functions that liver heat removing and eyesight improving, promoting the circulation of QI to induce diuresis, removing toxic substances.

Description

A kind of Anhydrite liver heat removing and eyesight improving bath effervescent tablets and preparation method thereof

Technical field

The present invention relates to a kind of health body-wash articles for use, particularly a kind of Anhydrite liver heat removing and eyesight improving bath effervescent tablets and preparation method thereof.

Background technology

In the traditional Chinese medical science, dipping method is one of external treatment, that is, use medicinal liquid or a kind of method containing medicinal liquid water washing bath whole body or local, and its form is varied：Have full bath and claim " liquid medicine bath "；The title again having " scalding ", " fumigation and wash method ", " demibain ", " foot bath " etc. of local bathing, especially scalds the most commonly used.

Chinese dipping, have existed since ancient times.Earliest hospital of China<52 Bingfang>In just have the dipping side controlling baby's epilepsy.《Book of Rites》In say " head has skin ulcer then to wash one's hair, and body has infectionss then to bathe ",《Huang di's Canon of Medicine》In have the record of " its be subject to exopathogen person, bathing the body with hot decoction to induce diaphoresis ", can say, the history of dipping is of long standing and well established, be laid a foundation in the Qin Dynasty, be developed in Chinese Tang, enrich in Song Ming, ripe in the Qing Dynasty.

The common dipping species in current market is broadly divided into three classes, including：Full bath, demibain, foot bath, using method is also very simply it is only necessary in the liquid medicine having dissolved to the bidet entering to mix up water temperature and the water yield or bath bucket, then steep body in water；Client progressively can experience the change of body generation during bathing.

The dipping mechanism of action in general, be medicine act on whole body flesh table, locally, affected part, and through absorb, circulation meridians blood vessels, inside reach internal organs, from outward appearance to inner essence, thus produce effect.Dipping bathing, can play dredging the meridian, activating blood circulation to dissipate blood stasis, wind dispelling cold expelling, heat-clearing and toxic substances removing, reducing swelling and alleviating pain, regulating YIN and YANG, coordinate internal organs, current QI and blood, moisten the health maintenance effect such as foster whole body.Modern pharmacology also confirms that, can improve the content of some immunoglobulins in blood after dipping, strengthens elasticity and the vigor of skin.

Medicine used by dipping on market mostly is medicinal liquid or medicated powder, medicinal liquid or medicated powder is not portable, and composition easily runs off, and medicinal liquid that most of Chinese herbal medicine process or medicated powder cannot the sufficiently effective effective ingredient playing Chinese crude drug, loss or the waste of drug effect can be caused, and be prepared into effervescent tablet and be then easy to preserve and carry, dissolution velocity is fast, bioavailability is high, can improve clinical efficacy.

At present, the medicine of liver heat removing and eyesight improving or health product have much on market, but the effect of most drug is not very well, and the side effect of most drug is more, and health can be damaged, and therefore, market is badly in need of a kind of Anhydrite liver heat removing and eyesight improving bath effervescent tablets and preparation method thereof.

Content of the invention

It is an object of the invention to provide a kind of Anhydrite liver heat removing and eyesight improving bath effervescent tablets and preparation method thereof, life-time service has liver heat removing and eyesight improving, promoting the circulation of QI to induce diuresis, the effect of removing toxic substances.

The purpose of the present invention is achieved through the following technical solutions：

A kind of Anhydrite liver heat removing and eyesight improving bath effervescent tablets and preparation method thereof, it is made up by following percentage by weight of raw material, Chinese medicine extract 20-35%, sour agent 10-20%, alkaline agent 10-20%, filler 30-50%, binding agent 1-10%, lubricant 1-10%, aromatic 0.1-1%；Raw materials by weight portion in described Chinese medicine extract, Anhydrite 50-70 part, Herba Potentillae Chinensis 15-20 part, Radix seu herba Heteropogonis Contorti 15-20 part, Herba Saniculae lamelligerae 8-12 part, Herba Canscorae 8-12 part, Fructus Broussonetiae 5-8 part, brown sugar (Saccharum Sinensis Roxb.) 5-8 part, Herba Orobanchess 5-8 part, Asbestuss 5-8 part, fruit 5-8 part.

In described Chinese medicine extract raw material press optimum weight number, 60 parts of Anhydrite, 18 parts of Herba Potentillae Chinensis, 17 parts of Radix seu herba Heteropogonis Contorti, 12 parts of Herba Saniculae lamelligerae, 10 parts of Herba Canscorae, 8 parts of Fructus Broussonetiae, 7 parts of brown sugar (Saccharum Sinensis Roxb.), 6 parts of Herba Orobanchess, 5 parts of Asbestuss, really 5 parts.

Described sour agent is citric acid or tartaric acid or citric acid or fumaric acid.

Described alkaline agent is sodium carbonate or sodium bicarbonate.

Described filler is Microcrystalline Cellulose, sucrose, Lactose, sodium chloride, the calcium sulfate mixing of one or more therein.

Described binding agent is starch slurry or Microcrystalline Cellulose.

Described lubricant is the mixing of one of magnesium stearate, sodium lauryl sulphate or two kinds.

Described a kind of Anhydrite liver heat removing and eyesight improving bath effervescent tablets and preparation method thereof, the mainly comprising the following steps of its preparation method：

Step 1, prepare Chinese medicine extract：

a , by weight, choose the Anhydrite of high-quality, Herba Potentillae Chinensis, Radix seu herba Heteropogonis Contorti, Herba Saniculae lamelligerae, Herba Canscorae, Fructus Broussonetiae, brown sugar (Saccharum Sinensis Roxb.), Herba Orobanchess, Asbestuss, really, clean and remove impurity, mix homogeneously after remove impurity, add water to cook three times, the water small fire adding 12-15 times for the first time decocts 90-120 minute, filters, and extracts filtrate, second plus 10-12 times of water moderate heat decocts 60-90 minute, filter, extract filtrate, the water big fire that third time adds 6-8 times decocts 30-45 minute, filter, extract filtrate, mix three filtrates, obtain mixed extract；

b , mixed extract is concentrated, be dried using spray dryer after concentration, obtain solid mixed extract, pulverized 60-80 mesh sieve, and obtained solid particle；

Step 2, mixing：

a , the solid particle obtaining in step 1 is divided into uniform two parts, choose sour agent, alkaline agent, filler, binding agent, carry out respectively pulverizing 60 mesh sieves；

b , first part of solid particle add the sour agent after pulverizing, filler, binding agent; it is then placed in trough type mixing machine; open trough type mixing machine to mix 30 minutes, add the PVP K30 ethanol solution that concentration is 1%, soft material processed into trough type mixing machine; add to soft material moderate after; soft material is put in oscillating granulator, makes granule, 60 eye mesh screen on oscillating granulator; dry, obtain acid particles；

c , second part Solid particle adds the alkaline agent after pulverizing, filler, binding agent; it is then placed in trough type mixing machine; open trough type mixing machine to mix 30 minutes, add the PVP K30 ethanol solution that concentration is 1%, soft material processed into trough type mixing machine; add to soft material moderate after; soft material is put in oscillating granulator, makes granule, 60 eye mesh screen on oscillating granulator; dry, obtain alkali grain；

d , by acid particles, alkali grain, lubricant, aromatic mixing, put into tabletting in automatic tableting press after fully mixing, aluminum-plastic packaged, obtain a kind of Anhydrite liver heat removing and eyesight improving bath effervescent tablets.

In medicine：Anhydrite liver heat removing and eyesight improving；Promoting the circulation of QI to induce diuresis；Main fever of the body excessive thirst；Cataract；Dysuria；Herba Potentillae Chinensis wind-damp dispelling, removing toxic substances；Control dysentery, rheumatism bones and muscles pain, paralysis, epilepsy, sore scabies；Radix seu herba Heteropogonis Contorti relieves heat and thirst；Expelling wind and removing dampness；Main calentura is quenched one's thirst；Rheumatic arthralgia；Cough；Vomit and diarrhoea；Herba Saniculae lamelligerae dissipates wind, lung heat clearing, resolving sputum, promoting the circulation of blood；Cure flu, cough, asthma, amenorrhea；Herba Canscorae heat-clearing and toxic substances removing, cough-relieving, pain relieving；For cough due to lung-heat, have a stomachache, icterohepatitises, venom；Fructus Broussonetiae nourishing kidney, liver heat removing, improving eyesight；Control asthenia, blurred vision, corneal nebula, aqueous vapor edema；Liver is delayed in brown sugar (Saccharum Sinensis Roxb.) spleen reinforcing；Promoting blood circulation to remove blood stasis；Main disease that postpartum lochia can't go；Xerostomia is vomitted the sound of vomiting；Weakness with emaciation cold and heat；Herba Orobanchess the kidney invigorating, strong muscle；Control kidney deficiency chills and pain of the waist and kness, sexual impotence, seminal emission；Asbestuss heat clearing away, relieving restlessness, diuresis；Control cough due to lung-heat, laryngopharynx swelling and pain, dysphoria with smothery sensation sun is fainted, dysuria, miliaria alba skin ulcer；Fruit stomach reinforcing；Promote the production of body fluid；Preventing or arresting vomiting；Cough-relieving；Master is thirsty；Vomiting；Lack of appetite；Cough .

Beneficial effects of the present invention：One kind of the present invention Anhydrite liver heat removing and eyesight improving bath effervescent tablets, to fever of the body excessive thirst, cataract etc. Main Disease Card serves to varying degrees Liver heat removing and eyesight improving, promoting the circulation of QI to induce diuresis, removing toxic substances Effect, There are health care, instant effect, pure natural, no side effectses.

The present invention uses the present invention through two groups of clinical verifications, one of which for treatment group, uses the present invention once daily, is within 7 days a course for the treatment of, and another group of matched group is taken Liver heat removing and eyesight improving Fructus Lycii tea , take once a day, be within 7 days a course for the treatment of, every group selection outpatient 110, wherein man 55, female 55, max age 75 years old, minimal ages 23 years old, clinical manifestation is fever of the body excessive thirst, cataract, dysuria, paralysis, epilepsy, sore scabies , table one is the contrasting data after taking a course for the treatment of：

Table 1 is taken two groups of courses for the treatment of of before and after and is compared (unit:People)

There were significant differences for treatment group and matched group, it will thus be seen that present invention application clinically has significant curative effect.

Specific embodiment

Embodiment 1

A kind of Anhydrite liver heat removing and eyesight improving bath effervescent tablets and preparation method thereof, it is made up by following percentage by weight of raw material, Chinese medicine extract 20-35%, sour agent 10-20%, alkaline agent 10-20%, filler 30-50%, binding agent 1-10%, lubricant 1-10%, aromatic 0.1-1%；Raw materials by weight portion in described Chinese medicine extract, Anhydrite 50-70 part, Herba Potentillae Chinensis 15-20 part, Radix seu herba Heteropogonis Contorti 15-20 part, Herba Saniculae lamelligerae 8-12 part, Herba Canscorae 8-12 part, Fructus Broussonetiae 5-8 part, brown sugar (Saccharum Sinensis Roxb.) 5-8 part, Herba Orobanchess 5-8 part, Asbestuss 5-8 part, fruit 5-8 part.

In described Chinese medicine extract raw material press optimum weight number, 60 parts of Anhydrite, 18 parts of Herba Potentillae Chinensis, 17 parts of Radix seu herba Heteropogonis Contorti, 12 parts of Herba Saniculae lamelligerae, 10 parts of Herba Canscorae, 8 parts of Fructus Broussonetiae, 7 parts of brown sugar (Saccharum Sinensis Roxb.), 6 parts of Herba Orobanchess, 5 parts of Asbestuss, really 5 parts.

Described sour agent is citric acid or tartaric acid or citric acid or fumaric acid.

Described alkaline agent is sodium carbonate or sodium bicarbonate.

Described filler is Microcrystalline Cellulose, sucrose, Lactose, sodium chloride, the calcium sulfate mixing of one or more therein.

Described binding agent is starch slurry or Microcrystalline Cellulose.

Described lubricant is the mixing of one of magnesium stearate, sodium lauryl sulphate or two kinds.

Described a kind of Anhydrite liver heat removing and eyesight improving bath effervescent tablets and preparation method thereof, the mainly comprising the following steps of its preparation method：

Step 1, prepare Chinese medicine extract：

a , by weight, choose the Anhydrite of high-quality, Herba Potentillae Chinensis, Radix seu herba Heteropogonis Contorti, Herba Saniculae lamelligerae, Herba Canscorae, Fructus Broussonetiae, brown sugar (Saccharum Sinensis Roxb.), Herba Orobanchess, Asbestuss, really, clean and remove impurity, mix homogeneously after remove impurity, add water to cook three times, the water small fire adding 12-15 times for the first time decocts 90-120 minute, filters, and extracts filtrate, second plus 10-12 times of water moderate heat decocts 60-90 minute, filter, extract filtrate, the water big fire that third time adds 6-8 times decocts 30-45 minute, filter, extract filtrate, mix three filtrates, obtain mixed extract；

b , mixed extract is concentrated, be dried using spray dryer after concentration, obtain solid mixed extract, pulverized 60-80 mesh sieve, and obtained solid particle；

Step 2, mixing：

a , the solid particle obtaining in step 1 is divided into uniform two parts, choose sour agent, alkaline agent, filler, binding agent, carry out respectively pulverizing 60 mesh sieves；

b , first part of solid particle add the sour agent after pulverizing, filler, binding agent; it is then placed in trough type mixing machine; open trough type mixing machine to mix 30 minutes, add the PVP K30 ethanol solution that concentration is 1%, soft material processed into trough type mixing machine; add to soft material moderate after; soft material is put in oscillating granulator, makes granule, 60 eye mesh screen on oscillating granulator; dry, obtain acid particles；

c , second part Solid particle adds the alkaline agent after pulverizing, filler, binding agent; it is then placed in trough type mixing machine; open trough type mixing machine to mix 30 minutes, add the PVP K30 ethanol solution that concentration is 1%, soft material processed into trough type mixing machine; add to soft material moderate after; soft material is put in oscillating granulator, makes granule, 60 eye mesh screen on oscillating granulator; dry, obtain alkali grain；

d , by acid particles, alkali grain, lubricant, aromatic mixing, put into tabletting in automatic tableting press after fully mixing, aluminum-plastic packaged, obtain a kind of Anhydrite liver heat removing and eyesight improving bath effervescent tablets.

Claims (8)

1. a kind of Anhydrite liver heat removing and eyesight improving bath effervescent tablets it is characterised in that：It is made up by following percentage by weight of raw material, Chinese medicine extract 20-35%, sour agent 10-20%, alkaline agent 10-20%, filler 30-50%, binding agent 1-10%, lubricant 1-10%, aromatic 0.1-1%；Raw materials by weight portion in described Chinese medicine extract, Anhydrite 50-70 part, Herba Potentillae Chinensis 15-20 part, Radix seu herba Heteropogonis Contorti 15-20 part, Herba Saniculae lamelligerae 8-12 part, Herba Canscorae 8-12 part, Fructus Broussonetiae 5-8 part, brown sugar (Saccharum Sinensis Roxb.) 5-8 part, Herba Orobanchess 5-8 part, Asbestuss 5-8 part, fruit 5-8 part.

2. a kind of Anhydrite liver heat removing and eyesight improving bath effervescent tablets according to claim 1 it is characterised in that：In described Chinese medicine extract raw material press optimum weight number, 60 parts of Anhydrite, 18 parts of Herba Potentillae Chinensis, 17 parts of Radix seu herba Heteropogonis Contorti, 12 parts of Herba Saniculae lamelligerae, 10 parts of Herba Canscorae, 8 parts of Fructus Broussonetiae, 7 parts of brown sugar (Saccharum Sinensis Roxb.), 6 parts of Herba Orobanchess, 5 parts of Asbestuss, really 5 parts.

3. a kind of Anhydrite liver heat removing and eyesight improving bath effervescent tablets according to claim 1 it is characterised in that：Described sour agent is citric acid or tartaric acid or citric acid or fumaric acid.

4. a kind of Anhydrite liver heat removing and eyesight improving bath effervescent tablets according to claim 1 it is characterised in that：Described alkaline agent is sodium carbonate or sodium bicarbonate.

5. a kind of Anhydrite liver heat removing and eyesight improving bath effervescent tablets according to claim 1 it is characterised in that：Described filler is Microcrystalline Cellulose, sucrose, Lactose, sodium chloride, the calcium sulfate mixing of one or more therein.

6. a kind of Anhydrite liver heat removing and eyesight improving bath effervescent tablets according to claim 1 it is characterised in that：Described binding agent is starch slurry or Microcrystalline Cellulose.

7. a kind of Anhydrite liver heat removing and eyesight improving bath effervescent tablets according to claim 1 it is characterised in that：Described lubricant is the mixing of one of magnesium stearate, sodium lauryl sulphate or two kinds.

8. a kind of Anhydrite liver heat removing and eyesight improving bath effervescent tablets according to claim 1-7 and preparation method thereof it is characterised in that：The mainly comprising the following steps of its preparation method：

Step 1, prepare Chinese medicine extract：

A, by weight, choose the Anhydrite of high-quality, Herba Potentillae Chinensis, Radix seu herba Heteropogonis Contorti, Herba Saniculae lamelligerae, Herba Canscorae, Fructus Broussonetiae, brown sugar (Saccharum Sinensis Roxb.), Herba Orobanchess, Asbestuss, really, clean and remove impurity, mix homogeneously after remove impurity, add water to cook three times, the water small fire adding 12-15 times for the first time decocts 90-120 minute, filters, and extracts filtrate, second plus 10-12 times of water moderate heat decocts 60-90 minute, filter, extract filtrate, the water big fire that third time adds 6-8 times decocts 30-45 minute, filter, extract filtrate, mix three filtrates, obtain mixed extract；

B, mixed extract is concentrated, be dried using spray dryer after concentration, obtain solid mixed extract, pulverized 60-80 mesh sieve, and obtained solid particle；

Step 2, mixing：

A, the solid particle obtaining in step 1 is divided into uniform two parts, chooses sour agent, alkaline agent, filler, binding agent, carry out respectively pulverizing 60 mesh sieves；

B, first part of solid particle add the sour agent after pulverizing, filler, binding agent; it is then placed in trough type mixing machine; open trough type mixing machine to mix 30 minutes, add the PVP K30 ethanol solution that concentration is 1%, soft material processed into trough type mixing machine; add to soft material moderate after; soft material is put in oscillating granulator, makes granule, 60 eye mesh screen on oscillating granulator; dry, obtain acid particles；

C, second part of solid particle add the alkaline agent after pulverizing, filler, binding agent; it is then placed in trough type mixing machine; open trough type mixing machine to mix 30 minutes, add the PVP K30 ethanol solution that concentration is 1%, soft material processed into trough type mixing machine; add to soft material moderate after; soft material is put in oscillating granulator, makes granule, 60 eye mesh screen on oscillating granulator; dry, obtain alkali grain；

D, by acid particles, alkali grain, lubricant, aromatic mixing, put into tabletting in automatic tableting press after fully mixing, aluminum-plastic packaged, obtain a kind of Anhydrite liver heat removing and eyesight improving bath effervescent tablets.