CN106466449A - A kind of stony edema is brought down a fever bath effervescent tablets and preparation method thereof of relieving summer heat - Google Patents

Abstract

A kind of stony edema is brought down a fever bath effervescent tablets and preparation method thereof of relieving summer heat, it is made up by following percentage by weight of raw material, Chinese medicine extract 20-35%, sour agent 10-20%, alkaline agent 10-20%, filler 30-50%, binding agent 1-10%, lubricant 1-10%, aromatic 0.1-1%；Raw materials by weight portion in described Chinese medicine extract, stony edema 50-70 part, Rhizoma Smilacis Bockii 15-20 part, Semen Trigonellae 15-20 part, pyrolusitum 8-12 part, Radix Urariae crinitae 8-12 part, Herba Damnacanthi 5-8 part, careless 5-8 part, Pericarpium Lagenariae sicerariae 5-8 part, Caulis Seu Folium Lespedezae Bicoloris 5-8 part, Herba Alternantherae Versicoloriss 5-8 part, the mainly comprising the following steps of preparation method：Step 1, prepare Chinese medicine extract：Clean, remove impurity, mixing, extraction；Step 2, mixing：Prepare acid particles, prepare alkali grain, mixing, tabletting.A kind of stony edema of the present invention is brought down a fever bath effervescent tablets of relieving summer heat, life-time service have functions that to bring down a fever relieve summer heat, relieving restlessness of quenching one's thirst, removing toxicity for eliminating carbuncles.

Description

A kind of stony edema is brought down a fever bath effervescent tablets and preparation method thereof of relieving summer heat

Technical field

The present invention relates to a kind of health body-wash articles for use, particularly a kind of stony edema is brought down a fever bath effervescent tablets and preparation method thereof of relieving summer heat.

Background technology

In the traditional Chinese medical science, dipping method is one of external treatment, that is, use medicinal liquid or a kind of method containing medicinal liquid water washing bath whole body or local, and its form is varied：Have full bath and claim " liquid medicine bath "；The title again having " scalding ", " fumigation and wash method ", " demibain ", " foot bath " etc. of local bathing, especially scalds the most commonly used.

Chinese dipping, have existed since ancient times.Earliest hospital of China<52 Bingfang>In just have the dipping side controlling baby's epilepsy.《Book of Rites》In say " head has skin ulcer then to wash one's hair, and body has infectionss then to bathe ",《Huang di's Canon of Medicine》In have the record of " its be subject to exopathogen person, bathing the body with hot decoction to induce diaphoresis ", can say, the history of dipping is of long standing and well established, be laid a foundation in the Qin Dynasty, be developed in Chinese Tang, enrich in Song Ming, ripe in the Qing Dynasty.

The common dipping species in current market is broadly divided into three classes, including：Full bath, demibain, foot bath, using method is also very simply it is only necessary in the liquid medicine having dissolved to the bidet entering to mix up water temperature and the water yield or bath bucket, then steep body in water；Client progressively can experience the change of body generation during bathing.

The dipping mechanism of action in general, be medicine act on whole body flesh table, locally, affected part, and through absorb, circulation meridians blood vessels, inside reach internal organs, from outward appearance to inner essence, thus produce effect.Dipping bathing, can play dredging the meridian, activating blood circulation to dissipate blood stasis, wind dispelling cold expelling, heat-clearing and toxic substances removing, reducing swelling and alleviating pain, regulating YIN and YANG, coordinate internal organs, current QI and blood, moisten the health maintenance effect such as foster whole body.Modern pharmacology also confirms that, can improve the content of some immunoglobulins in blood after dipping, strengthens elasticity and the vigor of skin.

Medicine used by dipping on market mostly is medicinal liquid or medicated powder, medicinal liquid or medicated powder is not portable, and composition easily runs off, and medicinal liquid that most of Chinese herbal medicine process or medicated powder cannot the sufficiently effective effective ingredient playing Chinese crude drug, loss or the waste of drug effect can be caused, and be prepared into effervescent tablet and be then easy to preserve and carry, dissolution velocity is fast, bioavailability is high, can improve clinical efficacy.

At present, bring down a fever in market the medicine relieved summer heat or health product have a lot, but the effect of most drug is not very well, and the side effect of most drug is more, and health can be damaged, and therefore, market is badly in need of a kind of Stony edema is brought down a fever bath effervescent tablets and preparation method thereof of relieving summer heat.

Content of the invention

Bath effervescent tablets and preparation method thereof of relieving summer heat it is an object of the invention to provide a kind of stony edema is brought down a fever, life-time service have bring down a fever relieve summer heat, relieving restlessness of quenching one's thirst, the effect of removing toxicity for eliminating carbuncles.

The purpose of the present invention is achieved through the following technical solutions：

A kind of stony edema is brought down a fever bath effervescent tablets and preparation method thereof of relieving summer heat, it is made up by following percentage by weight of raw material, Chinese medicine extract 20-35%, sour agent 10-20%, alkaline agent 10-20%, filler 30-50%, binding agent 1-10%, lubricant 1-10%, aromatic 0.1-1%；Raw materials by weight portion in described Chinese medicine extract, stony edema 50-70 part, Rhizoma Smilacis Bockii 15-20 part, Semen Trigonellae 15-20 part, pyrolusitum 8-12 part, Radix Urariae crinitae 8-12 part, Herba Damnacanthi 5-8 part, careless 5-8 part, Pericarpium Lagenariae sicerariae 5-8 part, Caulis Seu Folium Lespedezae Bicoloris 5-8 part, Herba Alternantherae Versicoloriss 5-8 part.

In described Chinese medicine extract, raw material presses optimum weight number, 60 parts of stony edema, 18 parts of Rhizoma Smilacis Bockii, 17 parts of Semen Trigonellae, 12 parts of pyrolusitum, 10 parts of Radix Urariae crinitae, 8 parts of Herba Damnacanthi, 7 parts of grass, 6 parts of Pericarpium Lagenariae sicerariae, 5 parts of Caulis Seu Folium Lespedezae Bicoloris, 5 parts of Herba Alternantherae Versicoloriss.

Described sour agent is citric acid or tartaric acid or citric acid or fumaric acid.

Described alkaline agent is sodium carbonate or sodium bicarbonate.

Described filler is Microcrystalline Cellulose, sucrose, Lactose, sodium chloride, the calcium sulfate mixing of one or more therein.

Described binding agent is starch slurry or Microcrystalline Cellulose.

Described lubricant is the mixing of one of magnesium stearate, sodium lauryl sulphate or two kinds.

A kind of described stony edema is brought down a fever bath effervescent tablets and preparation method thereof of relieving summer heat, the mainly comprising the following steps of its preparation method：

Step 1, prepare Chinese medicine extract：

a , by weight, the stony edema of selection high-quality, Rhizoma Smilacis Bockii, Semen Trigonellae, pyrolusitum, Radix Urariae crinitae, Herba Damnacanthi, grass, Pericarpium Lagenariae sicerariae, Caulis Seu Folium Lespedezae Bicoloris, Herba Alternantherae Versicoloriss, clean and remove impurity, mix homogeneously after remove impurity, add water to cook three times, the water small fire adding 12-15 times for the first time decocts 90-120 minute, filters, and extracts filtrate, second plus 10-12 times of water moderate heat decocts 60-90 minute, filter, extract filtrate, the water big fire that third time adds 6-8 times decocts 30-45 minute, filter, extract filtrate, mix three filtrates, obtain mixed extract；

b , mixed extract is concentrated, be dried using spray dryer after concentration, obtain solid mixed extract, pulverized 60-80 mesh sieve, and obtained solid particle；

Step 2, mixing：

a , the solid particle obtaining in step 1 is divided into uniform two parts, choose sour agent, alkaline agent, filler, binding agent, carry out respectively pulverizing 60 mesh sieves；

b , first part of solid particle add the sour agent after pulverizing, filler, binding agent; it is then placed in trough type mixing machine; open trough type mixing machine to mix 30 minutes, add the PVP K30 ethanol solution that concentration is 1%, soft material processed into trough type mixing machine; add to soft material moderate after; soft material is put in oscillating granulator, makes granule, 60 eye mesh screen on oscillating granulator; dry, obtain acid particles；

c , second part Solid particle adds the alkaline agent after pulverizing, filler, binding agent; it is then placed in trough type mixing machine; open trough type mixing machine to mix 30 minutes, add the PVP K30 ethanol solution that concentration is 1%, soft material processed into trough type mixing machine; add to soft material moderate after; soft material is put in oscillating granulator, makes granule, 60 eye mesh screen on oscillating granulator; dry, obtain alkali grain；

d , by acid particles, alkali grain, lubricant, aromatic mixing, put into tabletting in automatic tableting press after fully mixing, aluminum-plastic packaged, obtain a kind of stony edema and bring down a fever bath effervescent tablets of relieving summer heat.

In medicine：Stony edema is brought down a fever and is relieved summer heat；Quench one's thirst relieving restlessness；Main typhoid fever YANG toxin syndrome；Heat is very gone into a coma；Heatstroke excessive thirst；Rhizoma Smilacis Bockii expelling wind and removing dampness；Removing toxicity for eliminating carbuncles；Main air pain of dampness syndrome；Stranguria with turbid discharge；Leukorrhagia；Have loose bowels；Dysentery；Carbuncle sore tumefacting virus；Stubborn dermatitis；Burn and scald；Semen Trigonellae kidney-replenishing, dispelling cold and dampness；Control colic of cold type, abdomen coerces distension, the disturbance of lower legs due to pathogenic cold and dampness, the kidney deficiency soreness of waist, sexual impotence；Pyrolusitum blood stasis removing pain relieving, detumescence and promoting granulation；Control traumatic injury, incised wound, carbuncle；Radix Urariae crinitae promoting the circulation of QI to relieve pain；By drink resolving sputum；Main heart peratodynia；Cough due to fluid-retention；Herba Damnacanthi expelling wind and removing dampness, promoting blood circulation and stopping pain, for hepatitis, bones and muscles pain due to rheumatism, traumatic injury, caries pain；Careless liver heat removing removing heat from blood；Control hyperpyrexia dyspnea with rapid and short breath, hemoptysis, hematuria, acute conjunctivitis, erysipelas, carbuncle swells furunculosis；Pericarpium Lagenariae sicerariae diuretic, treating stranguria；Control edema, abdominal distention, jaundice, gonorrhea；Caulis Seu Folium Lespedezae Bicoloris moistening lung and clearing heat, relieving stranguria by diuresis；Control cough due to lung-heat, pertussis, epistaxis, gonorrhea；Herba Alternantherae Versicoloriss heat-clearing and toxic substances removing, cooling blood for hemostasis, removing food stagnancy removing blood stasis .

Beneficial effects of the present invention：One kind of the present invention Stony edema is brought down a fever bath effervescent tablets of relieving summer heat, and to typhoid fever YANG toxin syndrome, heat is very gone into a coma Main Disease Card serves to varying degrees Bring down a fever relieve summer heat, relieving restlessness of quenching one's thirst, removing toxicity for eliminating carbuncles Effect, There are health care, instant effect, pure natural, no side effectses.

The present invention uses the present invention through two groups of clinical verifications, one of which for treatment group, uses the present invention once daily, is within 7 days a course for the treatment of, and another group of matched group is taken Soup for relieving summer heat , daily using once, being within 7 days a course for the treatment of, every group selection outpatient 110, wherein man 55, female 55, max age 75 years old, minimal ages 25 years old, clinical manifestation is typhoid fever YANG toxin syndrome, and heat is very gone into a coma, heatstroke excessive thirst, Limbs asthenia , Rheumatic arthralgia, stranguria with turbid discharge , table one is the contrasting data after taking a course for the treatment of：

Table 1 is taken two groups of courses for the treatment of of before and after and is compared (unit:People)

There were significant differences for treatment group and matched group, it will thus be seen that present invention application clinically has significant curative effect.

Specific embodiment

Embodiment 1

A kind of stony edema is brought down a fever bath effervescent tablets and preparation method thereof of relieving summer heat, it is made up by following percentage by weight of raw material, Chinese medicine extract 20-35%, sour agent 10-20%, alkaline agent 10-20%, filler 30-50%, binding agent 1-10%, lubricant 1-10%, aromatic 0.1-1%；Raw materials by weight portion in described Chinese medicine extract, stony edema 50-70 part, Rhizoma Smilacis Bockii 15-20 part, Semen Trigonellae 15-20 part, pyrolusitum 8-12 part, Radix Urariae crinitae 8-12 part, Herba Damnacanthi 5-8 part, careless 5-8 part, Pericarpium Lagenariae sicerariae 5-8 part, Caulis Seu Folium Lespedezae Bicoloris 5-8 part, Herba Alternantherae Versicoloriss 5-8 part.

In described Chinese medicine extract, raw material presses optimum weight number, 60 parts of stony edema, 18 parts of Rhizoma Smilacis Bockii, 17 parts of Semen Trigonellae, 12 parts of pyrolusitum, 10 parts of Radix Urariae crinitae, 8 parts of Herba Damnacanthi, 7 parts of grass, 6 parts of Pericarpium Lagenariae sicerariae, 5 parts of Caulis Seu Folium Lespedezae Bicoloris, 5 parts of Herba Alternantherae Versicoloriss.

Described sour agent is citric acid or tartaric acid or citric acid or fumaric acid.

Described alkaline agent is sodium carbonate or sodium bicarbonate.

Described filler is Microcrystalline Cellulose, sucrose, Lactose, sodium chloride, the calcium sulfate mixing of one or more therein.

Described binding agent is starch slurry or Microcrystalline Cellulose.

Described lubricant is the mixing of one of magnesium stearate, sodium lauryl sulphate or two kinds.

A kind of described stony edema is brought down a fever bath effervescent tablets and preparation method thereof of relieving summer heat, the mainly comprising the following steps of its preparation method：

Step 1, prepare Chinese medicine extract：

a , by weight, the stony edema of selection high-quality, Rhizoma Smilacis Bockii, Semen Trigonellae, pyrolusitum, Radix Urariae crinitae, Herba Damnacanthi, grass, Pericarpium Lagenariae sicerariae, Caulis Seu Folium Lespedezae Bicoloris, Herba Alternantherae Versicoloriss, clean and remove impurity, mix homogeneously after remove impurity, add water to cook three times, the water small fire adding 12-15 times for the first time decocts 90-120 minute, filters, and extracts filtrate, second plus 10-12 times of water moderate heat decocts 60-90 minute, filter, extract filtrate, the water big fire that third time adds 6-8 times decocts 30-45 minute, filter, extract filtrate, mix three filtrates, obtain mixed extract；

b , mixed extract is concentrated, be dried using spray dryer after concentration, obtain solid mixed extract, pulverized 60-80 mesh sieve, and obtained solid particle；

Step 2, mixing：

a , the solid particle obtaining in step 1 is divided into uniform two parts, choose sour agent, alkaline agent, filler, binding agent, carry out respectively pulverizing 60 mesh sieves；

b , first part of solid particle add the sour agent after pulverizing, filler, binding agent; it is then placed in trough type mixing machine; open trough type mixing machine to mix 30 minutes, add the PVP K30 ethanol solution that concentration is 1%, soft material processed into trough type mixing machine; add to soft material moderate after; soft material is put in oscillating granulator, makes granule, 60 eye mesh screen on oscillating granulator; dry, obtain acid particles；

c , second part Solid particle adds the alkaline agent after pulverizing, filler, binding agent; it is then placed in trough type mixing machine; open trough type mixing machine to mix 30 minutes, add the PVP K30 ethanol solution that concentration is 1%, soft material processed into trough type mixing machine; add to soft material moderate after; soft material is put in oscillating granulator, makes granule, 60 eye mesh screen on oscillating granulator; dry, obtain alkali grain；

d , by acid particles, alkali grain, lubricant, aromatic mixing, put into tabletting in automatic tableting press after fully mixing, aluminum-plastic packaged, obtain a kind of stony edema and bring down a fever bath effervescent tablets of relieving summer heat.

Claims (8)

1. a kind of stony edema bring down a fever relieve summer heat bath effervescent tablets it is characterised in that：It is made up by following percentage by weight of raw material, Chinese medicine extract 20-35%, sour agent 10-20%, alkaline agent 10-20%, filler 30-50%, binding agent 1-10%, lubricant 1-10%, aromatic 0.1-1%；Raw materials by weight portion in described Chinese medicine extract, stony edema 50-70 part, Rhizoma Smilacis Bockii 15-20 part, Semen Trigonellae 15-20 part, pyrolusitum 8-12 part, Radix Urariae crinitae 8-12 part, Herba Damnacanthi 5-8 part, careless 5-8 part, Pericarpium Lagenariae sicerariae 5-8 part, Caulis Seu Folium Lespedezae Bicoloris 5-8 part, Herba Alternantherae Versicoloriss 5-8 part.

2. a kind of stony edema according to claim 1 bring down a fever relieve summer heat bath effervescent tablets it is characterised in that：In described Chinese medicine extract, raw material presses optimum weight number, 60 parts of stony edema, 18 parts of Rhizoma Smilacis Bockii, 17 parts of Semen Trigonellae, 12 parts of pyrolusitum, 10 parts of Radix Urariae crinitae, 8 parts of Herba Damnacanthi, 7 parts of grass, 6 parts of Pericarpium Lagenariae sicerariae, 5 parts of Caulis Seu Folium Lespedezae Bicoloris, 5 parts of Herba Alternantherae Versicoloriss.

3. a kind of stony edema according to claim 1 bring down a fever relieve summer heat bath effervescent tablets it is characterised in that：Described sour agent is citric acid or tartaric acid or citric acid or fumaric acid.

4. a kind of stony edema according to claim 1 bring down a fever relieve summer heat bath effervescent tablets it is characterised in that：Described alkaline agent is sodium carbonate or sodium bicarbonate.

5. a kind of stony edema according to claim 1 bring down a fever relieve summer heat bath effervescent tablets it is characterised in that：Described filler is Microcrystalline Cellulose, sucrose, Lactose, sodium chloride, the calcium sulfate mixing of one or more therein.

6. a kind of stony edema according to claim 1 bring down a fever relieve summer heat bath effervescent tablets it is characterised in that：Described binding agent is starch slurry or Microcrystalline Cellulose.

7. a kind of stony edema according to claim 1 bring down a fever relieve summer heat bath effervescent tablets it is characterised in that：Described lubricant is the mixing of one of magnesium stearate, sodium lauryl sulphate or two kinds.

8. a kind of stony edema according to claim 1-7 bring down a fever relieve summer heat bath effervescent tablets and preparation method thereof it is characterised in that：The mainly comprising the following steps of its preparation method：

Step 1, prepare Chinese medicine extract：

A, by weight, the stony edema of selection high-quality, Rhizoma Smilacis Bockii, Semen Trigonellae, pyrolusitum, Radix Urariae crinitae, Herba Damnacanthi, grass, Pericarpium Lagenariae sicerariae, Caulis Seu Folium Lespedezae Bicoloris, Herba Alternantherae Versicoloriss, clean and remove impurity, mix homogeneously after remove impurity, add water to cook three times, the water small fire adding 12-15 times for the first time decocts 90-120 minute, filters, and extracts filtrate, second plus 10-12 times of water moderate heat decocts 60-90 minute, filter, extract filtrate, the water big fire that third time adds 6-8 times decocts 30-45 minute, filter, extract filtrate, mix three filtrates, obtain mixed extract；

B, mixed extract is concentrated, be dried using spray dryer after concentration, obtain solid mixed extract, pulverized 60-80 mesh sieve, and obtained solid particle；

Step 2, mixing：

A, the solid particle obtaining in step 1 is divided into uniform two parts, chooses sour agent, alkaline agent, filler, binding agent, carry out respectively pulverizing 60 mesh sieves；

B, first part of solid particle add the sour agent after pulverizing, filler, binding agent; it is then placed in trough type mixing machine; open trough type mixing machine to mix 30 minutes, add the PVP K30 ethanol solution that concentration is 1%, soft material processed into trough type mixing machine; add to soft material moderate after; soft material is put in oscillating granulator, makes granule, 60 eye mesh screen on oscillating granulator; dry, obtain acid particles；

C, second part of solid particle add the alkaline agent after pulverizing, filler, binding agent; it is then placed in trough type mixing machine; open trough type mixing machine to mix 30 minutes, add the PVP K30 ethanol solution that concentration is 1%, soft material processed into trough type mixing machine; add to soft material moderate after; soft material is put in oscillating granulator, makes granule, 60 eye mesh screen on oscillating granulator; dry, obtain alkali grain；

D, by acid particles, alkali grain, lubricant, aromatic mixing, put into tabletting in automatic tableting press after fully mixing, aluminum-plastic packaged, obtain a kind of stony edema and bring down a fever bath effervescent tablets of relieving summer heat.