CN101837085B - Foot-bath effervescent tablet for improving constipation - Google Patents
Foot-bath effervescent tablet for improving constipation Download PDFInfo
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Abstract
The invention relates to a TCM (traditional Chinese medicine) compound preparation, in particular to a foot-bath effervescent tablet for improving constipation. The foot-bath effervescent tablet mainly comprises active components, effervescent excipient and adhesive and is characterized in that the active components comprise the following components by weight percentage: 8% to 25% of rheum officinale powder, 0.5% to 1.5% of borneol powder and the water extract of the following bulk drugs: 4% to 10% of immature bitter orange, 4% to 10% of pericarpium arecae, 4% to 10% of Chinese honeylocust fruit, 5% to 15% of dandelion, 8% to 25% of dried rhizome rehmannia and 5% to 25% of Magnolia officinalis.
Description
Invention field
The present invention relates to medicinal preparation, be specifically related to a kind of compound Chinese medicinal preparation.
Technical background
Constipation is the common a kind of disease of modern society, and its complex genesis is how relevant with gastrointestinal function, the kind of ingesting and custom, living habit, environmental factors, the mental status etc.The traditional Chinese medical science thinks that constipation is mainly caused by dryness-heat stagnating in the interior, depression and stagnation of QI, deficiency of body fluid and spleen-kidney vacuity cold.At present, still do not have specific medicament and be used for the treatment of various constipation, motherland's medical science has remarkable advantages aspect the preventing and treating of constipation.Because the incidence rate of constipation is higher, this just requires must be popular to its means of prevention and method, therefore, seeks that a kind of can to bring into play the popular again constipation method of preventing and treating of tcm characteristic be desirability.
It is in the majority with oral formulations to have the Chinese medicine that improves constipation now, and first pass effect is difficult to avoid, and takes bigger side effect for a long time.The tradition traditional Chinese medical science thinks that human five internal organs's six internal organs all have corresponding echo area on foot, and foot is the terminal of 6 meridians of human body, and more than 60 acupuncture point arranged.Therefore, adopt dipping pedicure a kind of desirable selection of can yet be regarded as.When bathing foot, both can make the effective ingredient Transdermal absorption of medicine, but the holographic echo area in effective stimulus vola again, thus regulate function, strengthening vital QI to eliminate pathogenic factors reaches the effect of building body.The product of at present commercially available dipping pedicure is powder and packed dosage form, form by direct pulverizing of medicine, the effective ingredient stripping of medicine is slow, and the especially fully stripping of effective ingredient of medicine under the acceptable water temperature of human body has obviously reduced bioavailability.
For the abundant technical problem of stripping of the effective ingredient that solves medicine under the acceptable water temperature of human body, publication number is that the patent application of CN1947684A has disclosed a kind of " effervescence tablets for feet-washing ", this effervescence tablets for feet-washing comprises the organic acid that accounts for gross mass 20%-40%, the sodium bicarbonate of 20-40%, the surfactant of 0.2-2.0% and the lubricant of 0.1%-5%, it is characterized in that: described Chinese medicine effervescence tablets for feet-washing also contains the Oleum Curcumae that accounts for gross mass 1-10%, 3-10% Radix Sophorae Flavescentis, 5-30% sodium chloride and an amount of binding agent.Raw material of Chinese medicine in the described scheme of above-mentioned patent application is Oleum Curcumae and Radix Sophorae Flavescentis, by the description of its description as can be known, described Radix Sophorae Flavescentis crude drug just just has been used as medicine through pulverizing, although therefore made effervescent tablet, dissolve rapidly in the time of making tablet meet water, but still fully stripping rapidly of the effective ingredient in the Radix Sophorae Flavescentis material powder under the acceptable water temperature of human body.In addition, limit, report that from its description and effect experiment visible described effervescence tablets for feet-washing is by the antibacterial anti-inflammatory anti-itch of realizing although the theme of above-mentioned patent application scheme does not carry out purposes.
Summary of the invention
In view of there is above-mentioned deficiency in prior art, technical problem to be solved by this invention provides a kind of foot-bath effervescent tablet that improves constipation.
The technical scheme that the present invention addresses the above problem is as described below:
A kind of foot-bath effervescent tablet that improves constipation, this foot-bath effervescent tablet mainly is made up of active ingredient, effervescent excipient and binding agent, it is characterized in that described active ingredient is to be made up of 8%～25% Radix Et Rhizoma Rhei powder, 0.5%～1.5% Borneolum Syntheticum powder and the water extract of following crude drug by the percentage by weight of crude drug: Fructus Aurantii Immaturus 4%～10%, Pericarpium Arecae 4%～10%, Fructus Gleditsia 4%～10%, Herba Taraxaci 5%～15%, the Radix Rehmanniae 8%～25%, Cortex Magnoliae Officinalis 5%～25%.
Foot-bath effervescent tablet of the present invention, wherein said active ingredient better is made up of 12.25%～23.25% Radix Et Rhizoma Rhei powder, 0.75%～1.40% Borneolum Syntheticum powder and the water extract of following crude drug: Fructus Aurantii Immaturus 5.50%～9.38%, Pericarpium Arecae 5.50%～9.38%, Fructus Gleditsia 5.50%～9.38%, Herba Taraxaci 7.50%～13.97%, the Radix Rehmanniae 12.25%～23.25%, Cortex Magnoliae Officinalis 10.00%～22.94%; The percentage by weight of preferably pressing crude drug is made up of 20.6% Radix Et Rhizoma Rhei powder, 1.2% Borneolum Syntheticum powder and the water extract of following crude drug: Fructus Aurantii Immaturus 8.4%, Pericarpium Arecae 8.4%, Fructus Gleditsia 8.4%, Herba Taraxaci 12.4%, the Radix Rehmanniae 20.6%, Cortex Magnoliae Officinalis 20%.
Foot-bath effervescent tablet of the present invention, wherein said active ingredient can adopt this area water extracting method commonly used to prepare, the method that the present invention recommends is as described below: get Fructus Aurantii Immaturus, Pericarpium Arecae, Fructus Gleditsia, Herba Taraxaci, the Radix Rehmanniae, Cortex Magnoliae Officinalis by proportioning, add 6-10 times of water gaging earlier, decocted 1.5-3 hour, and filtered; Filtering residue adds 6-10 times of water gaging again, decocts 1.5-3 hour, filters; Merge filtrate twice, concentrate, be drying to obtain.
Foot-bath effervescent tablet of the present invention, wherein said effervescent excipient is acid source and alkali source commonly used, wherein, described acid source is one or more in citric acid, tartaric acid, fumaric acid, adipic acid and the malic acid; Described alkali source is one or more in sodium carbonate, sodium bicarbonate, potassium carbonate, potassium bicarbonate and the calcium carbonate.Above-mentioned acid source is the best with citric acid or tartaric acid.Above-mentioned alkali source is the best with sodium carbonate, sodium bicarbonate or potassium bicarbonate.
Foot-bath effervescent tablet of the present invention, wherein said binding agent are a kind of or two or more in PEG4000～6000 of isopropyl alcohol, alcoholic solution and low relative molecular mass of hypromellose aqueous solution, PVP ethanol (water) solution, olefin(e) acid resin aqueous solution, starch slurry, ethanol, syrup, isopropyl alcohol, PEG (12000～20000).
Foot-bath effervescent tablet of the present invention, can also add the lubricant of being convenient to granulate according to the production technology needs, described lubricant is a kind of or two or more in Macrogol 4000, polyethylene glycol 6000, sodium lauryl sulphate, Stepanol MG, L-leucine, sodium benzoate, enuatrol, sodium chloride, sodium acetate, boric acid, magnesium stearate, Pulvis Talci, micropowder silica gel, sucrose fatty acid ester and the sodium stearyl fumarate.
Foot-bath effervescent tablet of the present invention can also add other adjuvant commonly used, as, filler, foaming agent are or/and correctives, and wherein, described filler is one or more in starch, microcrystalline Cellulose, dextrin lactose, mannitol, sucrose and the glucose; Described foaming agent is a kind of or two or more in tween 80, sodium lauryl sulphate and the hexadecanol; Described correctives is one or more in Oleum menthae, Oleum Rosae Rugosae, Fructus Citri Limoniae oil, apple essence, flavoring orange essence, Oleum Anisi Stellati and the flavoring banana essence.
Foot-bath effervescent tablet of the present invention is a kind of pharmaceutical preparation commonly used, and the selection of its adjuvant and preparation method can be implemented with reference to " the technical study overview of Chinese medicine effervescent tablet " literary composition of " traditional medicine " 2008 the 17th volumes the 10th phase the 72nd page of publication.
The traditional Chinese medical science thinks that constipation is mainly caused by dryness-heat stagnating in the interior, depression and stagnation of QI, deficiency of body fluid.This Chinese medicine compound is made up of Radix Et Rhizoma Rhei, Fructus Aurantii Immaturus, Pericarpium Arecae, Fructus Gleditsia, Herba Taraxaci, the Radix Rehmanniae, Cortex Magnoliae Officinalis, Borneolum Syntheticum etc., and its monarch drug is Radix Et Rhizoma Rhei, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, has the merit of purging heat and dredging bowels, eliminating blood stasis and inducing menstruation, dispelling the stagnated QI removing food stagnancy, the diffusing painful abdominal mass of reducing phlegm, therapeutic method to keep the adverse QI flowing downwards alleviating distention in middle-JIAO; Ministerial drug is Fructus Gleditsia, Herba Taraxaci, the Radix Rehmanniae, energy clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting; Adjuvant drug is a Pericarpium Arecae, the energy promoting the circulation of QI to alleviate the stagnation in middle-JIAO; Messenger drug is a Borneolum Syntheticum, and the energy waking up the patient from unconsciousness by clearing away heat has the merit of priming.The eight flavor mutual reinforcements between of full side, Xiang Zuo reach loosening bowel to relieve constipation, improve effects such as gastrointestinal function.
Foot-bath effervescent tablet of the present invention is put into water, under the effect of gas-producing disintegrant, at once producing a large amount of bubbles (carbon dioxide) rolls tablet up and down in water, quicken its disintegrate and thawing, and then make the rapid stripping of active ingredient in the tablet. when bathing foot, but effective ingredient is Transdermal absorption both, but function is regulated in the holographic echo area in effective stimulus vola again, and then realizes improving the purpose of constipation.
In order to understand the present invention better, clinical trial and the result who improves constipation with foot-bath effervescent tablet of the present invention illustrates its effect below.
Clinical experiment
One, physical data
All cases are the volunteer that the constipation symptom is arranged, male's 30 examples, age 40-76 year; Women's 30 examples, 37～74 years old age.Be divided at random and bathe foot group 30 examples (male 15 examples, women 15 examples); Blank group 30 examples (male 15 examples, women 15 examples).Treat preceding two groups of patients' sex, age, symptom integral there are no significant difference (P＞0.05), have comparability.
Two, include standard in
For including standard in, promptly in the past 12 months, have at least 12 weeks (needn't continuously) that following situation more than 2 or 2 takes place: 1. the defecation more than 1/4 is had a sense of urgency with Rome standard II; 2. the defecation more than 1/4 is dry and hard or hard; 3. there is defecation to feel not to the utmost during 1/4 above defecation; 4. there is anorectal to block during 1/4 above defecation or blocks sense; 5. 1/4 above defecation person to additionally help (as point scratch dig, massage at the bottom of the basin); 6. defecation＜3 time weekly do not have the passage of loose stools phenomenon, and are not enough to diagnose IBS.
Three, method
Bathe the foot group: the hot water of 10 of the foot-bath effervescent tablets of embodiment 1 being put into 4 liters 38～40 ℃ is bathed foot, and each 30 minutes, once a day, continuous 2 weeks.
Blank group: bathe foot with 4 liters 38～40 ℃ clear water, each 30 minutes, once a day, continuous 2 weeks.
Four, observation of curative effect
The clinical symptoms standards of grading: adopt " the constipation symptom and the curative effect evaluation questionnaire " of surgery branch of Chinese Medical Association anorectal surgical group establishment in 2005, this questionnaire is divided into 6 aspect problems: 1. difficult defecation; 2. feces character; 3. defecation time; 4. tenesmus, not to the utmost, the sense of expanding; 5. defecation frequency; 6. abdominal distention.Each problem score is 4 grade standards, and being respectively does not have 0 fen, and slight 1 minute, moderate 2 minutes, severe 3 minutes.According to score respectively in various degree, high more this symptom of representative of score is heavy more, and 6 aspect problem score additions just are constipation symptom total points.Evaluation time is respectively before the treatment beginning and after the treatment end.
Concrete standards of grading are as follows:
Difficult defecation: no difficult defecation is counted 0 fen, the idol have difficult defecation to count 1 fen, the time have difficult defecation to count 2 fens, often have difficult defecation to count 3 fens;
The feces character: according to stool character Bristol standard, 4-7 counts 0 fen, and 3 count 1 fen, and 2 count 2 fens, and 1 counts 3 fens;
Defecation time: defecation time＜10min/ time, count 0 fen, defecation time 10-15min/ time is counted 1 fen, and defecation time 15-25min/ time is counted 2 fens, and defecation time＞25min/ time is counted 3 fens;
Tenesmus, not to the utmost, the sense of expanding: do not have tenesmus, not to the utmost, the sense of expanding counts 0 fen, idol have tenesmus, not to the utmost, the sense of expanding counts 1 fen, the time have tenesmus, not to the utmost, the sense of expanding counts 2 fens, often have tenesmus, not to the utmost, the sense of expanding counts 3 fens;
The defecation frequency: 1-2 time/day, count 0 fen, 3 times/day, count 1 fen, 4-5 time/day, count 2 fens,＞5 times/day, count 3 fens;
Difficult defecation: no abdominal distention is counted 0 fen, the idol have abdominal distention to count 1 fen, the time have abdominal distention to count 2 fens, often have abdominal distention to count 3 fens;
Efficacy assessment standard: formulate score value * 100% before clinical symptoms integrated value improvement rate=(symptom integral value before the treatment-treatment back symptom integral value)/treatment with reference to " new Chinese medicine clinical research guideline ".
Efficacy assessment standard:
Produce effects: symptom integral value improvement rate 〉=70%;
Effectively: symptom integral value improvement rate 〉=50%;
Invalid: symptom is not seen obvious improvement or is instead seen deterioration, symptom integral value improvement rate＜50%.
Statistical procedures: total data adopts SPSS 13.0 statistics softwares to carry out statistical analysis, measurement data mean ± standard deviation (x ± s) expression.Symptom score more all adopted the t check before and after two groups of experimenters treated, and two groups of experimenter's clinical efficacies relatively adopt X
2Check.
Result of the test
The clinical symptoms integration relatively sees Table 1 before and after foot bath group and the blank group; Curative effect relatively sees Table 2; The improvement of cardinal symptom sign relatively sees Table 3.As known from Table 2, bathing foot group effect organizes apparently higher than blank.N in table 1～table 3 represents number.
Clinical symptoms was marked relatively (x ± s divides) before and after table 1 a liang group was bathed foot
| Group | n | Before bathing foot | After bathing foot |
| Bathe the foot group | 30 | 14.75±4.72 | 8.36±3.15ab |
| Blank group | 30 | 14.40±4.19 | 13.86±4.07 |
Foot bath is preceding compares with bath foot back: Pa＜0.05; Bathe foot group bath foot back and bathe the foot back relatively: Pb＜0.05 with blank the group
Table 2 liang group curative effect relatively
The foot group bathed by table 3 and blank group cardinal symptom sign is improved relatively
Foot bath is preceding compares with bath foot back: Pa＜0.05; Bathe foot group bath foot back and bathe the foot back relatively: Pb＜0.05 with blank the group
The specific embodiment
Embodiment 1
Prescription:
Crude drug: Radix Et Rhizoma Rhei 1236g, Fructus Aurantii Immaturus 504g, Pericarpium Arecae 504g, Fructus Gleditsia 504g, Herba Taraxaci 744g, Radix Rehmanniae 1236g, Cortex Magnoliae Officinalis 1200g, Borneolum Syntheticum 72g;
Adjuvant: citric acid 600g (in anhydride), sodium bicarbonate 780g, polyethylene glycol 6000 120g.
Method for making:
More than eight the flavor crude drug, get Radix Et Rhizoma Rhei powder and be broken into fine powder, sieve; Get Borneolum Syntheticum powder and be broken into fine powder, sieve; Six-element medical materials such as all the other Fructus Aurantii Immaturuss decoct with water secondary, add for the first time 8 times of water gagings, add 6 times of water gagings, each 3 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.25-1.30 (60 ℃ of survey), adds 7/10 Radix Et Rhizoma Rhei fine powder, mixing, 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, sodium bicarbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid fine powder that adds, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Get residue Radix Et Rhizoma Rhei fine powder, add polyethylene glycol 6000, the Borneolum Syntheticum mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly.
Embodiment 2
Prescription:
Crude drug: Radix Et Rhizoma Rhei 804g, Fructus Aurantii Immaturus 453g, Pericarpium Arecae 539g, Fructus Gleditsia 600g, Herba Taraxaci 900g, Radix Rehmanniae 1470g, Cortex Magnoliae Officinalis 1204g, Borneolum Syntheticum 30g;
Adjuvant: citric acid 300g (in anhydride), fumaric acid 300g, sodium bicarbonate 480g, sodium carbonate 300g, polyethylene glycol 6000 100g, Macrogol 4000 40g.
Method for making:
More than eight the flavor crude drug, get Radix Et Rhizoma Rhei powder and be broken into fine powder, sieve; Get Borneolum Syntheticum powder and be broken into fine powder, sieve; Six-element medical materials such as all the other Fructus Aurantii Immaturuss decoct with water secondary, add for the first time 10 times of water gagings, add 10 times of water gagings, each 3 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.25-1.30 (60 ℃ of survey), adds 7/10 Radix Et Rhizoma Rhei fine powder, mixing, 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Get residue Radix Et Rhizoma Rhei fine powder, add polyethylene glycol 6000, Macrogol 4000, Borneolum Syntheticum mixing, cross 80 mesh sieves, add above-mentioned two kinds of granules, mixing is pressed into 1000, promptly.
Embodiment 3
Prescription:
Crude drug: Radix Et Rhizoma Rhei 1054g, Fructus Aurantii Immaturus 256g, Pericarpium Arecae 352g, Fructus Gleditsia 447g, Herba Taraxaci 855g, Radix Rehmanniae 1500g, Cortex Magnoliae Officinalis 1491g, Borneolum Syntheticum 45g;
Adjuvant: citric acid 300g (in anhydride), fumaric acid 300g, potassium bicarbonate 480g, potassium carbonate 300g, Polyethylene Glycol 5000 100g, Macrogol 4000 30g, sodium lauryl sulphate 10g, mannitol 100g, Oleum menthae, Oleum Rosae Rugosae (in right amount).
Method for making:
More than eight the flavor crude drug, get Radix Et Rhizoma Rhei powder and be broken into fine powder, sieve; Get Borneolum Syntheticum powder and be broken into fine powder, sieve; Six-element medical materials such as all the other Fructus Aurantii Immaturuss decoct with water secondary, add for the first time 6 times of water gagings, add 6 times of water gagings, each 1.5 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.25-1.30 (60 ℃ of survey), adds 7/10 Radix Et Rhizoma Rhei fine powder, mixing, 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, potassium bicarbonate and potassium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds potassium bicarbonate and potassium carbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Get residue Radix Et Rhizoma Rhei fine powder, spray into Oleum menthae, Oleum Rosae Rugosae, add Polyethylene Glycol 5000, Macrogol 4000, sodium lauryl sulphate, mannitol, the Borneolum Syntheticum mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly.
Embodiment 4
Prescription:
Crude drug: Radix Et Rhizoma Rhei 1443g, Fructus Aurantii Immaturus 427g, Pericarpium Arecae 244g, Fructus Gleditsia 336g, Herba Taraxaci 610g, Radix Rehmanniae 1442g, Cortex Magnoliae Officinalis 1440g, Borneolum Syntheticum 60g;
Adjuvant: citric acid 300g (in anhydride), fumaric acid 300g, sodium bicarbonate 480g, sodium carbonate 300g, polyethylene glycol 6000 100g, Polyethylene Glycol 5000 30g, sodium lauryl sulphate 10g, Pulvis Talci 10g, mannitol 100g, Oleum menthae (in right amount).
Method for making:
More than eight the flavor crude drug, get Radix Et Rhizoma Rhei powder and be broken into fine powder, sieve; Get Borneolum Syntheticum powder and be broken into fine powder, sieve; Six-element medical materials such as all the other Fructus Aurantii Immaturuss decoct with water secondary, add for the first time 8 times of water gagings, add 8 times of water gagings, each 8 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.25-1.30 (60 ℃ of survey), adds 9/10 Radix Et Rhizoma Rhei fine powder, mixing, 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Get residue Radix Et Rhizoma Rhei fine powder, spray into Oleum menthae, add polyethylene glycol 6000, Borneolum Syntheticum, Polyethylene Glycol 5000, sodium lauryl sulphate, Pulvis Talci, the mannitol mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly.
Embodiment 5
Prescription:
Crude drug: Radix Et Rhizoma Rhei 1486g, Fructus Aurantii Immaturus 600g, Pericarpium Arecae 452g, Fructus Gleditsia 286g, Herba Taraxaci 500g, Radix Rehmanniae 1100g, Cortex Magnoliae Officinalis 1500g, Borneolum Syntheticum 76g;
Adjuvant: citric acid 600g (in anhydride), sodium bicarbonate 1200g, polyethylene glycol 6000 120g.
Method for making:
More than eight the flavor crude drug, get Radix Et Rhizoma Rhei powder and be broken into fine powder, sieve; Get Borneolum Syntheticum powder and be broken into fine powder, sieve; Six-element medical materials such as all the other Fructus Aurantii Immaturuss decoct with water secondary, add for the first time 8 times of water gagings, add 7 times of water gagings, each 2.5 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.25-1.30 (60 ℃ of survey), adds 8/10 Radix Et Rhizoma Rhei fine powder, mixing, 60 ℃ of dryings are ground into fine powder, sieve.Citric acid, sodium bicarbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid fine powder that adds, mixing is made granule, 60 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate fine powder, and mixing is made granule, 60 ℃ of dryings, No. two sieve granulate; Get residue Radix Et Rhizoma Rhei fine powder, add polyethylene glycol 6000, the Borneolum Syntheticum mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly.
Embodiment 6
Prescription:
Crude drug: Radix Et Rhizoma Rhei 1500g, Fructus Aurantii Immaturus 592g, Pericarpium Arecae 600g, Fructus Gleditsia 541g, Herba Taraxaci 498g, Radix Rehmanniae 970g, Cortex Magnoliae Officinalis 1209g, Borneolum Syntheticum 90g;
Adjuvant: citric acid 300g (in anhydride), fumaric acid 300g, sodium bicarbonate 600g, sodium carbonate 600g, polyethylene glycol 6000 100g, Macrogol 4000 40g.
Method for making:
More than eight the flavor crude drug, get Radix Et Rhizoma Rhei powder and be broken into fine powder, sieve; Get Borneolum Syntheticum powder and be broken into fine powder, sieve; Six-element medical materials such as all the other Fructus Aurantii Immaturuss decoct with water secondary, add for the first time 9 times of water gagings, add 9 times of water gagings, each 1.5 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.25-1.30 (60 ℃ of survey), adds 6/10 Radix Et Rhizoma Rhei fine powder, mixing, 90 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 90 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 90 ℃ of dryings, No. two sieve granulate; Get residue Radix Et Rhizoma Rhei fine powder, add polyethylene glycol 6000, Borneolum Syntheticum, the Macrogol 4000 mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly.
Embodiment 7
Prescription:
Crude drug: Radix Et Rhizoma Rhei 1428g, Fructus Aurantii Immaturus 600g, Pericarpium Arecae 569g, Fructus Gleditsia 600g, Herba Taraxaci 863g, Radix Rehmanniae 892g, Cortex Magnoliae Officinalis 1018g, Borneolum Syntheticum 30g;
Adjuvant: citric acid 300g (in anhydride), fumaric acid 300g, sodium bicarbonate 580g, sodium carbonate 400g, Polyethylene Glycol 5000 100g, Macrogol 4000 30g, sodium lauryl sulphate 10g, mannitol 100g, Oleum menthae (in right amount).
Method for making:
More than eight the flavor crude drug, get Radix Et Rhizoma Rhei powder and be broken into fine powder, sieve; Get Borneolum Syntheticum powder and be broken into fine powder, sieve; Six-element medical materials such as all the other Fructus Aurantii Immaturuss decoct with water secondary, add for the first time 6 times of water gagings, add 8 times of water gagings, each 3 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.25-1.30 (60 ℃ of survey), adds 8/10 Radix Et Rhizoma Rhei fine powder, mixing, 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Get residue Radix Et Rhizoma Rhei fine powder, spray into Oleum menthae, add Polyethylene Glycol 5000, Borneolum Syntheticum, Macrogol 4000, sodium lauryl sulphate, the mannitol mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly.
Embodiment 8
Prescription:
Crude drug: Radix Et Rhizoma Rhei 1163g, Fructus Aurantii Immaturus 590g, Pericarpium Arecae 600g, Fructus Gleditsia 600g, Herba Taraxaci 900g, Radix Rehmanniae 1416g, Cortex Magnoliae Officinalis 731g, Borneolum Syntheticum 45g;
Adjuvant: citric acid 400g (in anhydride), fumaric acid 300g, sodium bicarbonate 580g, sodium carbonate 400g, polyethylene glycol 6000 100g, Macrogol 4000 30g, sodium lauryl sulphate 10g, Pulvis Talci 10g, mannitol 100g, Oleum menthae (in right amount).
Method for making:
More than eight the flavor crude drug, get Radix Et Rhizoma Rhei powder and be broken into fine powder, sieve; Get Borneolum Syntheticum powder and be broken into fine powder, sieve; Six-element medical materials such as all the other Fructus Aurantii Immaturuss decoct with water secondary, add for the first time 7 times of water gagings, add 7 times of water gagings, each 2 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.25-1.30 (60 ℃ of survey), adds 7/10 Radix Et Rhizoma Rhei fine powder, mixing, 75 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 75 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 75 ℃ of dryings, No. two sieve granulate; Get residue Radix Et Rhizoma Rhei fine powder, spray into Oleum menthae, add polyethylene glycol 6000, Borneolum Syntheticum, Macrogol 4000, sodium lauryl sulphate, Pulvis Talci, the mannitol mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly.
Embodiment 9
Prescription:
Crude drug: Radix Et Rhizoma Rhei 1074g, Fructus Aurantii Immaturus 557g, Pericarpium Arecae 585g, Fructus Gleditsia 585g, Herba Taraxaci 870g, Radix Rehmanniae 1331g, Cortex Magnoliae Officinalis 938g, Borneolum Syntheticum 60g;
Adjuvant: Oleum Rosae Rugosae (in right amount), citric acid 1200g (in anhydride), sodium bicarbonate 600g, polyethylene glycol 6000 120g.
Method for making:
More than eight the flavor crude drug, get Radix Et Rhizoma Rhei powder and be broken into fine powder, sieve; Get Borneolum Syntheticum powder and be broken into fine powder, sieve; Six-element medical materials such as all the other Fructus Aurantii Immaturuss decoct with water secondary, add for the first time 6 times of water gagings, add 6 times of water gagings, each 2.5 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.25-1.30 (60 ℃ of survey), adds 7/10 Radix Et Rhizoma Rhei fine powder, mixing, 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, sodium bicarbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid fine powder that adds, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Get residue Radix Et Rhizoma Rhei fine powder, spray into Oleum Rosae Rugosae, add polyethylene glycol 6000, the Borneolum Syntheticum mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly.
Embodiment 10
Prescription:
Crude drug: Radix Et Rhizoma Rhei 956g, Fructus Aurantii Immaturus 418g, Pericarpium Arecae 507g, Fructus Gleditsia 625g, Herba Taraxaci 900g, Radix Rehmanniae 1500g, Cortex Magnoliae Officinalis 1119g, Borneolum Syntheticum 75g;
Adjuvant: citric acid 600g (in anhydride), fumaric acid 600g, sodium bicarbonate 300g, sodium carbonate 300g, polyethylene glycol 6000 100g, Macrogol 4000 40g.
Method for making:
More than eight the flavor crude drug, get Radix Et Rhizoma Rhei powder and be broken into fine powder, sieve; Get Borneolum Syntheticum powder and be broken into fine powder, sieve; Six-element medical materials such as all the other Fructus Aurantii Immaturuss decoct with water secondary, add for the first time 8 times of water gagings, add 8 times of water gagings, each 2 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.25-1.30 (60 ℃ of survey), adds 7/10 Radix Et Rhizoma Rhei fine powder, mixing, 85 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 85 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 85 ℃ of dryings, No. two sieve granulate; Get residue Radix Et Rhizoma Rhei fine powder, add polyethylene glycol 6000, Borneolum Syntheticum, the Macrogol 4000 mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly.
Embodiment 11
Prescription:
Crude drug: Radix Et Rhizoma Rhei 1030g, Fructus Aurantii Immaturus 343g, Pericarpium Arecae 343g, Fructus Gleditsia 437g, Herba Taraxaci 886g, Radix Rehmanniae 1511g, Cortex Magnoliae Officinalis 1460g, Borneolum Syntheticum 90g;
Adjuvant: citric acid 400g (in anhydride), fumaric acid 800g, sodium bicarbonate 200g, sodium carbonate 400g, polyethylene glycol 6000 100g, Macrogol 4000 30g, sodium lauryl sulphate 10g, mannitol 100g, Oleum menthae (in right amount).
Method for making:
More than eight the flavor crude drug, get Radix Et Rhizoma Rhei powder and be broken into fine powder, sieve; Get Borneolum Syntheticum powder and be broken into fine powder, sieve; Six-element medical materials such as all the other Fructus Aurantii Immaturuss decoct with water secondary, add for the first time 7.5 times of water gagings, add 6 times of water gagings, each 2.5 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.25-1.30 (60 ℃ of survey), adds 7/10 Radix Et Rhizoma Rhei fine powder, mixing, 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Get residue Radix Et Rhizoma Rhei fine powder, spray into Oleum menthae, add polyethylene glycol 6000, Borneolum Syntheticum, Macrogol 4000, sodium lauryl sulphate, the mannitol mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly.
Embodiment 12
Prescription:
Crude drug: Radix Et Rhizoma Rhei 1414g, Fructus Aurantii Immaturus 404g, Pericarpium Arecae 329g, Fructus Gleditsia 329g, Herba Taraxaci 598g, Radix Rehmanniae 1400g, Cortex Magnoliae Officinalis 1496g, Borneolum Syntheticum 30g;
Adjuvant: citric acid 900g (in anhydride), fumaric acid 300g, sodium bicarbonate 100g, sodium carbonate 500g, Polyethylene Glycol 5000 100g, Macrogol 4000 30g, sodium lauryl sulphate 10g, Pulvis Talci 10g, mannitol 100g, Oleum menthae (in right amount).
Method for making:
More than eight the flavor crude drug, get Radix Et Rhizoma Rhei powder and be broken into fine powder, sieve; Get Borneolum Syntheticum powder and be broken into fine powder, sieve; Six-element medical materials such as all the other Fructus Aurantii Immaturuss decoct with water secondary, add for the first time 8 times of water gagings, add 6 times of water gagings, each 3 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.25-1.30 (60 ℃ of survey), adds 7/10 Radix Et Rhizoma Rhei fine powder, mixing, 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Get residue Radix Et Rhizoma Rhei fine powder, spray into Oleum menthae, add Polyethylene Glycol 5000, Borneolum Syntheticum, Macrogol 4000, sodium lauryl sulphate, Pulvis Talci, the mannitol mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly.
Embodiment 13
Prescription:
Crude drug: Radix Et Rhizoma Rhei 1500g, Fructus Aurantii Immaturus 556g, Pericarpium Arecae 458g, Fructus Gleditsia 363g, Herba Taraxaci 497g, Radix Rehmanniae 1081g, Cortex Magnoliae Officinalis 1500g, Borneolum Syntheticum 45g;
Adjuvant: citric acid 900g (in anhydride), sodium bicarbonate 900g, Polyethylene Glycol 5000 120g.
Method for making:
More than eight the flavor crude drug, get Radix Et Rhizoma Rhei powder and be broken into fine powder, sieve; Get Borneolum Syntheticum powder and be broken into fine powder, sieve; Six-element medical materials such as all the other Fructus Aurantii Immaturuss decoct with water secondary, add for the first time 10 times of water gagings, add 6.5 times of water gagings, each 3 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.25-1.30 (60 ℃ of survey), adds 7/10 Radix Et Rhizoma Rhei fine powder, mixing, 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, sodium bicarbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid fine powder that adds, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Get residue Radix Et Rhizoma Rhei fine powder, add Polyethylene Glycol 5000, the Borneolum Syntheticum mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly.
Embodiment 14
Prescription:
Crude drug: Radix Et Rhizoma Rhei 1500g, Fructus Aurantii Immaturus 600g, Pericarpium Arecae 540g, Fructus Gleditsia 523g, Herba Taraxaci 611g, Radix Rehmanniae 1003g, Cortex Magnoliae Officinalis 1163g, Borneolum Syntheticum 60g;
Adjuvant: citric acid 450g (in anhydride), fumaric acid 450g, sodium bicarbonate 480g, sodium carbonate 420g, polyethylene glycol 6000 100g, Macrogol 4000 40g.
Method for making:
More than eight the flavor crude drug, get Radix Et Rhizoma Rhei powder and be broken into fine powder, sieve; Get Borneolum Syntheticum powder and be broken into fine powder, sieve; Six-element medical materials such as all the other Fructus Aurantii Immaturuss decoct with water secondary, add for the first time 7 times of water gagings, add 6 times of water gagings, each 3 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.25-1.30 (60 ℃ of survey), adds 7/10 Radix Et Rhizoma Rhei fine powder, mixing, 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Get residue Radix Et Rhizoma Rhei fine powder, add polyethylene glycol 6000, Borneolum Syntheticum, the Macrogol 4000 mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly.
Embodiment 15
Prescription:
Crude drug: Radix Et Rhizoma Rhei 1353g, Fructus Aurantii Immaturus 526g, Pericarpium Arecae 600g, Fructus Gleditsia 600g, Herba Taraxaci 818g, Radix Rehmanniae 1085g, Cortex Magnoliae Officinalis 943g, Borneolum Syntheticum 75g;
Adjuvant: citric acid 600g (in anhydride), fumaric acid 300g, sodium bicarbonate 600g, sodium carbonate 300g, polyethylene glycol 6000 100g, Macrogol 4000 30g, sodium lauryl sulphate 10g, mannitol 100g, Oleum menthae (in right amount).
Method for making:
More than eight the flavor crude drug, get Radix Et Rhizoma Rhei powder and be broken into fine powder, sieve; Get Borneolum Syntheticum powder and be broken into fine powder, sieve; Six-element medical materials such as all the other Fructus Aurantii Immaturuss decoct with water secondary, add for the first time 9 times of water gagings, add 7.5 times of water gagings, each 3 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.25-1.30 (60 ℃ of survey), adds 7/10 Radix Et Rhizoma Rhei fine powder, mixing, 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Get residue Radix Et Rhizoma Rhei fine powder, spray into Oleum menthae, add polyethylene glycol 6000, Borneolum Syntheticum, Macrogol 4000, sodium lauryl sulphate, the mannitol mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly.
Embodiment 16
Prescription:
Crude drug: Radix Et Rhizoma Rhei 1442g, Fructus Aurantii Immaturus 600g, Pericarpium Arecae 570g, Fructus Gleditsia 540g, Herba Taraxaci 871g, Radix Rehmanniae 1173g, Cortex Magnoliae Officinalis 716g, Borneolum Syntheticum 90g;
Adjuvant: citric acid 500g (in anhydride), fumaric acid 400g, sodium bicarbonate 4000g, calcium carbonate 500g, polyethylene glycol 6000 100g, Macrogol 4000 30g, sodium lauryl sulphate 10g, Pulvis Talci 10g, mannitol 100g, Oleum menthae (in right amount).
Method for making:
More than eight the flavor crude drug, get Radix Et Rhizoma Rhei powder and be broken into fine powder, sieve; Get Borneolum Syntheticum powder and be broken into fine powder, sieve; Six-element medical materials such as all the other Fructus Aurantii Immaturuss decoct with water secondary, add for the first time 8 times of water gagings, add 8 times of water gagings, each 2.5 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.25-1.30 (60 ℃ of survey), adds 7/10 Radix Et Rhizoma Rhei fine powder, mixing, 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and calcium carbonate sodium are dry respectively, are ground into fine powder, sieve, and is standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and calcium carbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Get residue Radix Et Rhizoma Rhei fine powder, spray into Oleum menthae, add polyethylene glycol 6000, Borneolum Syntheticum, Macrogol 4000, sodium lauryl sulphate, Pulvis Talci, the mannitol mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly.
Embodiment 17
Prescription:
Crude drug: Radix Et Rhizoma Rhei 896g, Fructus Aurantii Immaturus 585g, Pericarpium Arecae 600g, Fructus Gleditsia 570g, Herba Taraxaci 900g, Radix Rehmanniae 1404g, Cortex Magnoliae Officinalis 1015g, Borneolum Syntheticum 30g;
Adjuvant: Oleum menthae (in right amount), citric acid 600g (in anhydride), potassium bicarbonate 1200g, polyethylene glycol 6000 120g.
Method for making:
More than eight the flavor crude drug, get Radix Et Rhizoma Rhei powder and be broken into fine powder, sieve; Get Borneolum Syntheticum powder and be broken into fine powder, sieve; Six-element medical materials such as all the other Fructus Aurantii Immaturuss decoct with water secondary, add for the first time 9 times of water gagings, add 9 times of water gagings, each 2.5 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.25-1.30 (60 ℃ of survey), adds 5/10 Radix Et Rhizoma Rhei fine powder, mixing, 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, potassium bicarbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid fine powder that adds, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds the potassium bicarbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Get residue Radix Et Rhizoma Rhei fine powder, spray into Oleum menthae, add polyethylene glycol 6000, Borneolum Syntheticum, mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly.
Embodiment 18
Prescription:
Crude drug: Radix Et Rhizoma Rhei 989g, Fructus Aurantii Immaturus 343g, Pericarpium Arecae 518g, Fructus Gleditsia 600g, Herba Taraxaci 900g, Radix Rehmanniae 1500g, Cortex Magnoliae Officinalis 1150g, Borneolum Syntheticum 45g;
Adjuvant: citric acid 300g (in anhydride), fumaric acid 300g, sodium bicarbonate 600g, sodium carbonate 600g, polyethylene glycol 6000 100g, Macrogol 4000 40g.
Method for making:
More than eight the flavor crude drug, get Radix Et Rhizoma Rhei powder and be broken into fine powder, sieve; Get Borneolum Syntheticum powder and be broken into fine powder, sieve; Six-element medical materials such as all the other Fructus Aurantii Immaturuss decoct with water secondary, add for the first time 8.5 times of water gagings, add 6.5 times of water gagings, each 3 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.25-1.30 (60 ℃ of survey), adds 6/10 Radix Et Rhizoma Rhei fine powder, mixing, 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Get residue Radix Et Rhizoma Rhei fine powder, add polyethylene glycol 6000, Borneolum Syntheticum, the Macrogol 4000 mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly.
Embodiment 19
Prescription:
Crude drug: Radix Et Rhizoma Rhei 1054g, Fructus Aurantii Immaturus 352g, Pericarpium Arecae 256g, Fructus Gleditsia 447g, Herba Taraxaci 900g, Radix Rehmanniae 1440g, Cortex Magnoliae Officinalis 1491g, Borneolum Syntheticum 60g;
Adjuvant: citric acid 100g (in anhydride), fumaric acid 500g, sodium bicarbonate 900g, sodium carbonate 300g, polyethylene glycol 6000 100g, Macrogol 4000 30g, sodium lauryl sulphate 10g, mannitol 100g, Oleum menthae (in right amount).
Method for making:
More than eight the flavor crude drug, get Radix Et Rhizoma Rhei powder and be broken into fine powder, sieve; Get Borneolum Syntheticum powder and be broken into fine powder, sieve; Six-element medical materials such as all the other Fructus Aurantii Immaturuss decoct with water secondary, add for the first time 9 times of water gagings, add 7 times of water gagings, each 2 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.25-1.30 (60 ℃ of survey), adds 7/10 Radix Et Rhizoma Rhei fine powder, mixing, 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Get residue Radix Et Rhizoma Rhei fine powder, spray into Oleum menthae, add polyethylene glycol 6000, Borneolum Syntheticum, Macrogol 4000, sodium lauryl sulphate, the mannitol mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly.
Embodiment 20
Prescription:
Crude drug: Radix Et Rhizoma Rhei 1442g, Fructus Aurantii Immaturus 427g, Pericarpium Arecae 336g, Fructus Gleditsia 244g, Herba Taraxaci 610g, Radix Rehmanniae 1366g, Cortex Magnoliae Officinalis 1500g, Borneolum Syntheticum 75g;
Adjuvant: citric acid 500g (in anhydride), fumaric acid 100g, sodium bicarbonate 200g, sodium carbonate 1000g, polyethylene glycol 6000 100g, Macrogol 4000 30g, sodium lauryl sulphate 10g, Pulvis Talci 10g, mannitol 100g, Oleum menthae (in right amount).
Method for making:
More than eight the flavor crude drug, get Radix Et Rhizoma Rhei powder and be broken into fine powder, sieve; Get Borneolum Syntheticum powder and be broken into fine powder, sieve; Six-element medical materials such as all the other Fructus Aurantii Immaturuss decoct with water secondary, add for the first time 8 times of water gagings, add 8 times of water gagings, each 2 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.25-1.30 (60 ℃ of survey), adds 7/10 Radix Et Rhizoma Rhei fine powder, mixing, 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid Borneolum Syntheticum of adding, fine powder, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Get residue Radix Et Rhizoma Rhei fine powder, spray into Oleum menthae, add polyethylene glycol 6000, Macrogol 4000, sodium lauryl sulphate, Pulvis Talci, the mannitol mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly.
Embodiment 21
Prescription:
Crude drug: Radix Et Rhizoma Rhei 1500g, Fructus Aurantii Immaturus 600g, Pericarpium Arecae 482g, Fructus Gleditsia 390g, Herba Taraxaci 385g, Radix Rehmanniae 1143g, Cortex Magnoliae Officinalis 1410g, Borneolum Syntheticum 90g;
Adjuvant: fumaric acid 1200g, sodium bicarbonate 800g, polyethylene glycol 6000 120g.
Method for making:
More than eight the flavor crude drug, get Radix Et Rhizoma Rhei powder and be broken into fine powder, sieve; Get Borneolum Syntheticum powder and be broken into fine powder, sieve; Six-element medical materials such as all the other Fructus Aurantii Immaturuss decoct with water secondary, add for the first time 7 times of water gagings, add 7 times of water gagings, each 2.5 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.25-1.30 (60 ℃ of survey), adds 7/10 Radix Et Rhizoma Rhei fine powder, mixing, 80 ℃ of dryings are ground into fine powder, sieve.Fumaric acid, sodium bicarbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a fumaric acid fine powder that adds, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Get residue Radix Et Rhizoma Rhei fine powder, add polyethylene glycol 6000, Borneolum Syntheticum, mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly.
Embodiment 22
Prescription:
Crude drug: Radix Et Rhizoma Rhei 1500g, Fructus Aurantii Immaturus 570g, Pericarpium Arecae 600g, Fructus Gleditsia 552g, Herba Taraxaci 660g, Radix Rehmanniae 848g, Cortex Magnoliae Officinalis 1240g, Borneolum Syntheticum 30g;
Adjuvant: citric acid 700g (in anhydride), fumaric acid 500g, sodium bicarbonate 480g, sodium carbonate 400g, polyethylene glycol 6000 100g, Macrogol 4000 40g.
Method for making:
More than eight the flavor crude drug, get Radix Et Rhizoma Rhei powder and be broken into fine powder, sieve; Get Borneolum Syntheticum powder and be broken into fine powder, sieve; Six-element medical materials such as all the other Fructus Aurantii Immaturuss decoct with water secondary, add for the first time 8 times of water gagings, add 8 times of water gagings, each 2.5 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.25-1.30 (60 ℃ of survey), adds 7/10 Radix Et Rhizoma Rhei fine powder, mixing, 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Get residue Radix Et Rhizoma Rhei fine powder, add polyethylene glycol 6000, the Macrogol 4000 mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly.
Embodiment 23
Prescription:
Crude drug: Radix Et Rhizoma Rhei 1485g, Fructus Aurantii Immaturus 600g, Pericarpium Arecae 570g, Fructus Gleditsia 584g, Herba Taraxaci 714g, Radix Rehmanniae 947g, Cortex Magnoliae Officinalis 1055g, Borneolum Syntheticum 45g;
Adjuvant: citric acid 800g (in anhydride), fumaric acid 400g, sodium bicarbonate 400g, sodium carbonate 800g, polyethylene glycol 6000 100g, Macrogol 4000 30g, sodium lauryl sulphate 10g, mannitol 100g, Oleum menthae (in right amount).
Method for making:
More than eight the flavor crude drug, get Radix Et Rhizoma Rhei powder and be broken into fine powder, sieve; Get Borneolum Syntheticum powder and be broken into fine powder, sieve; Six-element medical materials such as all the other Fructus Aurantii Immaturuss decoct with water secondary, add for the first time 7.5 times of water gagings, add 6.5 times of water gagings, each 3 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.25-1.30 (60 ℃ of survey), adds 7/10 Radix Et Rhizoma Rhei fine powder, mixing, 70 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 70 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 70 ℃ of dryings, No. two sieve granulate; Get residue Radix Et Rhizoma Rhei fine powder, spray into Oleum menthae, add polyethylene glycol 6000, Borneolum Syntheticum, Macrogol 4000, sodium lauryl sulphate, the mannitol mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly.
Embodiment 24
Prescription:
Crude drug: Radix Et Rhizoma Rhei 1250g, Fructus Aurantii Immaturus 540g, Pericarpium Arecae 600g, Fructus Gleditsia 600g, Herba Taraxaci 900g, Radix Rehmanniae 1250g, Cortex Magnoliae Officinalis 800g, Borneolum Syntheticum 60g;
Adjuvant: citric acid 700g (in anhydride), fumaric acid 300g, sodium bicarbonate 700g, sodium carbonate 300g, polyethylene glycol 6000 100g, Macrogol 4000 30g, sodium lauryl sulphate 10g, Pulvis Talci 10g, mannitol 100g, Oleum menthae (in right amount).
Method for making:
More than eight the flavor crude drug, get Radix Et Rhizoma Rhei powder and be broken into fine powder, sieve; Get Borneolum Syntheticum powder and be broken into fine powder, sieve; Six-element medical materials such as all the other Fructus Aurantii Immaturuss decoct with water secondary, add for the first time 10 times of water gagings, add 6 times of water gagings, each 3 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.25-1.30 (60 ℃ of survey), adds 9/10 Radix Et Rhizoma Rhei fine powder, mixing, 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Get residue Radix Et Rhizoma Rhei fine powder, spray into Oleum menthae, add the polyethylene glycol 6000 Borneolum Syntheticum, Macrogol 4000, sodium lauryl sulphate, Pulvis Talci, the mannitol mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly.
Embodiment 25
Prescription:
Crude drug: Radix Et Rhizoma Rhei 923g, Fructus Aurantii Immaturus 506g, Pericarpium Arecae 600g, Fructus Gleditsia 540g, Herba Taraxaci 885g, Radix Rehmanniae 1429g, Cortex Magnoliae Officinalis 1042g, Borneolum Syntheticum 75g;
Adjuvant: citric acid 600g (in anhydride), sodium bicarbonate 780g, polyethylene glycol 6000 120g.
Method for making:
More than eight the flavor crude drug, get Radix Et Rhizoma Rhei powder and be broken into fine powder, sieve; Get Borneolum Syntheticum powder and be broken into fine powder, sieve; Six-element medical materials such as all the other Fructus Aurantii Immaturuss decoct with water secondary, add for the first time 8 times of water gagings, add 6 times of water gagings, each 3 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.25-1.30 (60 ℃ of survey), adds 7/10 Radix Et Rhizoma Rhei fine powder, mixing, 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, sodium bicarbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid fine powder that adds, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Get residue Radix Et Rhizoma Rhei fine powder, add polyethylene glycol 6000, Borneolum Syntheticum, mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly.
Embodiment 26
Prescription:
Crude drug: Radix Et Rhizoma Rhei 1021g, Fructus Aurantii Immaturus 356g, Pericarpium Arecae 443g, Fructus Gleditsia 600g, Herba Taraxaci 815g, Radix Rehmanniae 1500g, Cortex Magnoliae Officinalis 1180g, Borneolum Syntheticum 90g;
Adjuvant: citric acid 800g (in anhydride), fumaric acid 250g, sodium bicarbonate 580g, sodium carbonate 300g, polyethylene glycol 6000 100g, Macrogol 4000 40g.
Method for making:
More than eight the flavor crude drug, get Radix Et Rhizoma Rhei powder and be broken into fine powder, sieve; Get Borneolum Syntheticum powder and be broken into fine powder, sieve; Six-element medical materials such as all the other Fructus Aurantii Immaturuss decoct with water secondary, add for the first time 10 times of water gagings, add 10 times of water gagings, each 3 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.25-1.30 (60 ℃ of survey), adds 7/10 Radix Et Rhizoma Rhei fine powder, mixing, 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Get residue Radix Et Rhizoma Rhei fine powder, add polyethylene glycol 6000, Borneolum Syntheticum, the Macrogol 4000 mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly.
Embodiment 27
Prescription:
Crude drug: Radix Et Rhizoma Rhei 1091g, Fructus Aurantii Immaturus 368g, Pericarpium Arecae 274g, Fructus Gleditsia 368g, Herba Taraxaci 900g, Radix Rehmanniae 1470g, Cortex Magnoliae Officinalis 1500g, Borneolum Syntheticum 30g;
Adjuvant: citric acid 800g (in anhydride), fumaric acid 300g, sodium bicarbonate 780g, sodium carbonate 300g, polyethylene glycol 6000 100g, Macrogol 4000 30g, sodium lauryl sulphate 10g, mannitol 100g, Oleum menthae (in right amount).
Method for making:
More than eight the flavor crude drug, get Radix Et Rhizoma Rhei powder and be broken into fine powder, sieve; Get Borneolum Syntheticum powder and be broken into fine powder, sieve; Six-element medical materials such as all the other Fructus Aurantii Immaturuss decoct with water secondary, add for the first time 7.5 times of water gagings, add 6 times of water gagings, each 3 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.25-1.30 (60 ℃ of survey), adds 8/10 Radix Et Rhizoma Rhei fine powder, mixing, 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Get residue Radix Et Rhizoma Rhei fine powder, spray into Oleum menthae, add polyethylene glycol 6000, Borneolum Syntheticum, Macrogol 4000, sodium lauryl sulphate, the mannitol mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly.
Embodiment 28
Prescription:
Crude drug: Radix Et Rhizoma Rhei 1492g, Fructus Aurantii Immaturus 442g, Pericarpium Arecae 347g, Fructus Gleditsia 253g, Herba Taraxaci 474g, Radix Rehmanniae 1492g, Cortex Magnoliae Officinalis 1455g, Borneolum Syntheticum 45g;
Adjuvant: citric acid 600g (in anhydride), fumaric acid 400g, sodium bicarbonate 480g, sodium carbonate 600g, polyethylene glycol 6000 100g, Macrogol 4000 30g, sodium lauryl sulphate 10g, Pulvis Talci 10g, mannitol 100g, Oleum menthae (in right amount).
Method for making:
More than eight the flavor crude drug, get Radix Et Rhizoma Rhei powder and be broken into fine powder, sieve; Get Borneolum Syntheticum powder and be broken into fine powder, sieve; Six-element medical materials such as all the other Fructus Aurantii Immaturuss decoct with water secondary, add for the first time 8 times of water gagings, add 9 times of water gagings, each 3 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.25-1.30 (60 ℃ of survey), adds 7/10 Radix Et Rhizoma Rhei fine powder, mixing, 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Get residue Radix Et Rhizoma Rhei fine powder, spray into Oleum menthae, add polyethylene glycol 6000, Borneolum Syntheticum, Macrogol 4000, sodium lauryl sulphate, Pulvis Talci, the mannitol mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly.
Claims (4)
1. foot-bath effervescent tablet that improves constipation, this foot-bath effervescent tablet mainly is made up of effective ingredient, effervescent excipient and binding agent, it is characterized in that described active ingredient is to be made up of 8%～25% Radix Et Rhizoma Rhei powder, 0.5%～1.5% Borneolum Syntheticum powder and the water extract of following crude drug by the percentage by weight of crude drug:
Fructus Aurantii Immaturus 4%～10%, Pericarpium Arecae 4%～10%, Fructus Gleditsia 4%～10%, Herba Taraxaci 5%～15%, the Radix Rehmanniae 8%～25%, Cortex Magnoliae Officinalis 5%～25%.
2. a kind of foot-bath effervescent tablet that improves constipation according to claim 1 is characterized in that described effective ingredient is to be made up of 12.25%～23.25% Radix Et Rhizoma Rhei powder, 0.75%～1.40% Borneolum Syntheticum powder and the water extract of following crude drug by the percentage by weight of crude drug:
Fructus Aurantii Immaturus 5.50%～9.38%, Pericarpium Arecae 5.50%～9.38%, Fructus Gleditsia 5.50%～9.38%, Herba Taraxaci 7.50%～13.97%, the Radix Rehmanniae 12.25%～23.25%, Cortex Magnoliae Officinalis 10.00%～22.94%.
3. a kind of foot-bath effervescent tablet that improves constipation according to claim 2 is characterized in that described effective ingredient is to be made up of 20.6% Radix Et Rhizoma Rhei powder, 1.2% Borneolum Syntheticum powder and the water extract of following crude drug by the percentage by weight of crude drug:
Fructus Aurantii Immaturus 8.4%, Pericarpium Arecae 8.4%, Fructus Gleditsia 8.4%, Herba Taraxaci 12.4%, the Radix Rehmanniae 20.6%, Cortex Magnoliae Officinalis 20%.
4. according to claim 1,2 or 3 described a kind of foot-bath effervescent tablets that improve constipation, it is characterized in that described water extract is prepared by following method:
Get Fructus Aurantii Immaturus, Pericarpium Arecae, Fructus Gleditsia, Herba Taraxaci, the Radix Rehmanniae, Cortex Magnoliae Officinalis by proportioning, add 6-10 times of water gaging earlier, decocted 1.5-3 hour, filter; Filtering residue adds 6-10 times of water gaging again, decocts 1.5-3 hour, filters; Merge filtrate twice, concentrate, be drying to obtain.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010101797357A CN101837085B (en) | 2010-05-17 | 2010-05-17 | Foot-bath effervescent tablet for improving constipation |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010101797357A CN101837085B (en) | 2010-05-17 | 2010-05-17 | Foot-bath effervescent tablet for improving constipation |
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| Publication Number | Publication Date |
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| CN101837085A CN101837085A (en) | 2010-09-22 |
| CN101837085B true CN101837085B (en) | 2011-10-05 |
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| CN2010101797357A Expired - Fee Related CN101837085B (en) | 2010-05-17 | 2010-05-17 | Foot-bath effervescent tablet for improving constipation |
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| CN104887564A (en) * | 2015-05-14 | 2015-09-09 | 北京同仁堂安徽中药材有限公司 | Health care footbath powder for invigorating blood circulation and fending off cold and preparation method thereof |
| CN114053209A (en) * | 2021-12-27 | 2022-02-18 | 江西九华药业有限公司 | Traditional Chinese medicine suppository for clearing bowels and defecation and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1194151A (en) * | 1997-03-26 | 1998-09-30 | 蒲绍卿 | Traditional Chinese medicine changtongning for curing chronic constipation |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1194151A (en) * | 1997-03-26 | 1998-09-30 | 蒲绍卿 | Traditional Chinese medicine changtongning for curing chronic constipation |
Non-Patent Citations (1)
| Title |
|---|
| 郑学宝等.虚性便秘的研究思路.《中国中医基础医学杂志》.2001,第7卷(第10期),22-24. * |
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