CN101837109B - Foot-bath effervescent tablet for improving sleep - Google Patents
Foot-bath effervescent tablet for improving sleep Download PDFInfo
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Abstract
The invention relates to a TCM (traditional Chinese medicine) compound preparation, in particular to a foot-bath effervescent tablet for improving sleep. The foot-bath effervescent tablet mainly comprises active components, effervescent excipient and adhesive and is characterized in that the active components comprise the following components by weight percentage: 10% to 30% of rhizoma acori graminei, 5% to 20% of rhizoma cyperi, 5% to 20% of tuber fleeceflower stem, 5% to 20% of radix curcumae, 8% to 25% of tuckahoe, 5% to 20% of Chinese magnoliavine fruit and 4% to 15% of radix bupleuri. The foot-bath effervescent tablet of the invention can regulate the Zang-Fu functions and achieve the purposes of invigorating the qi, enriching the blood, dredging the brain, balancing yin and yang and improving the sleep.
Description
Invention field
The present invention relates to medicinal preparation, be specifically related to a kind of compound Chinese medicinal preparation.
Technical background
Insomnia is often can not obtain a kind of disease that ortho sleep is a feature, for a variety of causes causes that difficulty falling asleep, Depth of sleep or frequency too short (the shallow aypnia of sleeping), early awakening and the length of one's sleep are not enough or of poor quality etc., usually be called DIMS (D1MS), motherland's medical science is referred to as " being insomnia ", " insomnia ", " must not crouch ", " unable to close the eyes ".At present, not clear and definite fully as yet for the mechanism of insomnia, modern medicine does not also have the better prevention way to it.Yet, motherland's medical science the insomnia prevent and treat aspect have remarkable advantages.Because the incidence rate of insomnia is very high, this just requires must be popular to its means of prevention and method, therefore, seeks that a kind of can to bring into play the popular again insomnia method of preventing and treating of tcm characteristic be desirability.
The Chinese medicine of existing improvement sleep is in the majority with oral formulations, and first pass effect is difficult to avoid, and takes bigger side effect for a long time.The tradition traditional Chinese medical science thinks that human five internal organs's six internal organs all have corresponding echo area on foot, and foot is the terminal of 6 meridians of human body, and more than 60 acupuncture point arranged.Therefore, adopt dipping pedicure a kind of desirable selection of can yet be regarded as.When bathing foot, both can make the effective ingredient Transdermal absorption of medicine, but the holographic echo area in effective stimulus vola again, thus regulate function, strengthening vital QI to eliminate pathogenic factors reaches the effect of building body.The product of at present commercially available dipping pedicure is powder and packed dosage form, form by direct pulverizing of medicine, the effective ingredient stripping of medicine is slow, and the especially fully stripping of effective ingredient of medicine under the acceptable water temperature of human body has obviously reduced bioavailability.
For the abundant technical problem of stripping of the effective ingredient that solves medicine under the acceptable water temperature of human body, the patent application that is disclosed as CN1947684A has disclosed a kind of " effervescence tablets for feet-washing ", this effervescence tablets for feet-washing comprises the organic acid that accounts for gross mass 20%-40%, the sodium bicarbonate of 20-40%, the surfactant of 0.2-2.0% and the lubricant of 0.1%-5%, it is characterized in that: described Chinese medicine effervescence tablets for feet-washing also contains the Oleum Curcumae that accounts for gross mass 1-10%, 3-10% Radix Sophorae Flavescentis, 5-30% sodium chloride and an amount of binding agent.Raw material of Chinese medicine in the described scheme of above-mentioned patent application is Oleum Curcumae and Radix Sophorae Flavescentis, by the description of its description as can be known, described Radix Sophorae Flavescentis crude drug just just has been used as medicine through pulverizing, although therefore made effervescent tablet, dissolve rapidly in the time of making tablet meet water, but still fully stripping rapidly of the effective ingredient in the Radix Sophorae Flavescentis material powder under the acceptable water temperature of human body.In addition, limit, report that from its description and effect experiment visible described effervescence tablets for feet-washing is by the antibacterial anti-inflammatory anti-itch of realizing although the theme of above-mentioned patent application scheme does not carry out purposes.
Summary of the invention
In view of there is above-mentioned deficiency in prior art, technical problem to be solved by this invention provides a kind of foot-bath effervescent tablet that improves sleep.
The technical scheme that the present invention addresses the above problem is as described below:
A kind of foot-bath effervescent tablet that improves sleep, this foot-bath effervescent tablet mainly is made up of active ingredient, effervescent excipient and binding agent, it is characterized in that, described active ingredient is to be made up of 5%～20% the Rhizoma Chuanxiong power and the water extract of following crude drug by the percentage by weight of crude drug: Rhizoma Acori Graminei 10%～30%, Rhizoma Cyperi 5%～20%, Caulis Polygoni Multiflori 5%～20%, Radix Curcumae 5%～20%, Poria 8%～25%, Fructus Schisandrae Chinensis 5%～20%, Radix Bupleuri 4%～15%.
Foot-bath effervescent tablet of the present invention, wherein said active ingredient better is to be made up of 8.75%～16.25% the Rhizoma Chuanxiong power and the water extract of following crude drug by the percentage by weight of crude drug: Rhizoma Acori Graminei 15.00%～25.00%, Rhizoma Cyperi 8.75%～16.25%, Caulis Polygoni Multiflori 8.75%～16.25%, Radix Curcumae 8.75%～16.25%, Poria 12.25%～20.75%, Fructus Schisandrae Chinensis 8.75%～16.25%, Radix Bupleuri 6.75%～12.25%; The percentage by weight of preferably pressing crude drug is made up of 11.5% the Rhizoma Chuanxiong power and the water extract of following crude drug: Rhizoma Acori Graminei 18.5%, Rhizoma Cyperi 11.5%, Caulis Polygoni Multiflori 11.5%, Radix Curcumae 11.5%, Poria 15.3%, Fructus Schisandrae Chinensis 11.5%, Radix Bupleuri 8.7%.
Foot-bath effervescent tablet of the present invention, wherein said active ingredient can adopt this area water extracting method commonly used to prepare, the method that the present invention recommends is as described below: get Rhizoma Acori Graminei, Rhizoma Cyperi, Caulis Polygoni Multiflori, Radix Curcumae, Poria, Fructus Schisandrae Chinensis and Radix Bupleuri by proportioning, add 6-10 times of water gaging earlier, decocted 1.5-3 hour, and filtered; Filtering residue adds 6-10 times of water gaging again, decocts 1.5-3 hour, filters; Merge filtrate twice, concentrate, be drying to obtain.
Foot-bath effervescent tablet of the present invention, wherein said effervescent excipient is acid source and alkali source commonly used, wherein, described acid source is one or more in citric acid, tartaric acid, fumaric acid, adipic acid and the malic acid; Described alkali source is one or more in sodium carbonate, sodium bicarbonate, potassium carbonate, potassium bicarbonate and the calcium carbonate.Above-mentioned acid source is the best with citric acid or tartaric acid.Above-mentioned alkali source is the best with sodium carbonate, sodium bicarbonate or potassium bicarbonate.
Foot-bath effervescent tablet of the present invention, wherein said binding agent are a kind of or two or more in PEG4000～6000 of isopropyl alcohol, alcoholic solution and low relative molecular mass of hypromellose aqueous solution, PVP ethanol (water) solution, olefin(e) acid resin aqueous solution, starch slurry, ethanol, syrup, isopropyl alcohol, PEG (12000～20000).
Foot-bath effervescent tablet of the present invention, can also add the lubricant of being convenient to granulate according to the production technology needs, described lubricant is a kind of or two or more in Macrogol 4000, polyethylene glycol 6000, sodium lauryl sulphate, Stepanol MG, L-leucine, sodium benzoate, enuatrol, sodium chloride, sodium acetate, boric acid, magnesium stearate, Pulvis Talci, micropowder silica gel, sucrose fatty acid ester and the sodium stearyl fumarate.
Foot-bath effervescent tablet of the present invention can also add other adjuvant commonly used, as, filler, foaming agent are or/and correctives, and wherein, described filler is one or more in starch, microcrystalline Cellulose, dextrin lactose, mannitol, sucrose and the glucose; Described foaming agent is a kind of or two or more in tween 80, sodium lauryl sulphate and the hexadecanol; Described correctives is one or more in Oleum menthae, Oleum Rosae Rugosae, Fructus Citri Limoniae oil, apple essence, flavoring orange essence, Oleum Anisi Stellati and the flavoring banana essence.
Foot-bath effervescent tablet of the present invention is a kind of pharmaceutical preparation commonly used, and the selection of its adjuvant and preparation method can be implemented with reference to " the technical study overview of Chinese medicine effervescent tablet " literary composition of " traditional medicine " 2008 the 17th volumes the 10th phase the 72nd page of publication.
It is clinical sleeping to be difficult for to have a sleepless night, and easily waking up in the back of sleeping, can not sleep sometimes sleeping and sometimes waking again after waking up, or be insomnia all night and be its syndrome characteristics, and often with lassitude in the daytime, bradykinesia, fatigue and asthenia, very then vexed annoyance has a strong impact on physical and mental health and work, studying and living.Ancient Chinese medicine doctor think the etiology and pathogenesis of insomnia be main diseases with the internal injury caused by excess of seven emotions because of, its internal organs that relate to nothing more than the heart, spleen, liver, gallbladder, kidney, its pathogenesis always belongs to battalion to be defended and becomes estranged, imbalance of YIN and YANG be disease, or the deficiency of YIN can not receive sun, or the excess of YANG must not be gone into the moon.Active ingredient of the present invention is made by Fructus Schisandrae Chinensis, Rhizoma Chuanxiong, Rhizoma Acori Graminei, Rhizoma Cyperi, Caulis Polygoni Multiflori, Radix Curcumae, Poria, Radix Bupleuri etc., its monarch drug is Fructus Schisandrae Chinensis, Caulis Polygoni Multiflori, Rhizoma Chuanxiong, and Bearberry Extract is astringent or styptic treatment for spontaneous sweating, the merit of supplementing QI for promoting the production of body fluid, kidney calming, tranquilizing by nourishing the heart, collateral dredging circulation of qi promoting; Ministerial drug is Radix Curcumae, Radix Bupleuri, Rhizoma Cyperi, the pain relieving of energy blood-activating and qi-promoting, dispersing the stagnated live-QI to relieve the stagnation of QI; Adjuvant drug is Poria, Rhizoma Acori Graminei, has the merit of mind tranquilizing and the heart calming.Full side eight flavor compatibilities, combined effect reaches benefiting vital QI and blood, relaxes and lead to brain network, Yin Yang balancing, improves effects such as sleep.
Foot-bath effervescent tablet of the present invention is put into water, under the effect of gas-producing disintegrant, at once producing a large amount of bubbles (carbon dioxide) rolls tablet up and down in water, quicken its disintegrate and thawing, and then make the rapid stripping of active ingredient in the tablet, when bathing foot, but effective ingredient is Transdermal absorption both, but function is regulated in the holographic echo area in effective stimulus vola again, and then realizes improving the purpose of sleep.
In order to understand the present invention better, improve the clinical trial and the result that sleep with foot-bath effervescent tablet of the present invention below its effect is described.
Clinical experiment
One, physical data
All cases are the volunteer that insomnia is arranged, male's 32 examples, age 66-76 year, the course of disease 1～15 year; Women's 28 examples, 67～74 years old age; The course of disease 1.5～12 years.Be divided at random and bathe foot group 30 examples (male 16 examples, women 14 examples); Blank group 30 examples (male 16 examples, women 14 examples).Treat preceding two groups of patients' sex, age, insomnia integration there are no significant difference (P＞0.05), have comparability.
Two, include standard in
Classical symptom with insomnia continues to meet Chinese medical discrimination standard person more than one month.Its traditional Chinese medical science diagnostic criteria promptly has the classical symptom of following insomnia with reference to " new Chinese medicine clinical research guideline " (1993) of Ministry of Public Health promulgation: difficulty falling asleep, awakening often, sleep and unstable or wake up after can not sleep again; Wake up too early morning, and can not fall asleep night, and daytime is drowsy, does not have enough sleep 5 hours, and history of repeated attack is arranged.
Three, exclusion standard:
Get rid of systemic disease such as pain, heating, cough, operation etc., and external interference factor causer and psychotic and look into EKG, hepatic and renal function when being admitted to hospital, just blood, urine, conventional unusual person.
Four, method
Bathe the foot group: the hot water of 10 of the foot-bath effervescent tablets of embodiment 1 being put into 4 liters 38～40 ℃ is bathed foot, and each 30 minutes, once a day, continuous 2 weeks.
Blank group: bathe foot with 4 liters 38～40 ℃ clear water, each 30 minutes, once a day, continuous 2 weeks.
Five, observation of curative effect
The clinical symptoms standards of grading: the sleep quality index (PSQI) of this standard reference Pittsburgh is formulated, respectively at bathe foot begin before and bathe foot when finishing by professional through training, according to 9 problems in the following sleep quality index questionnaire, the sleep quality that each case is nearest 1 month is divided into sleep quality, time for falling asleep, Sleep efficiency, sleep disorder, hypnotic drug and 6 factors of daytime function obstacle and scores respectively, each factor is pressed 0-3 and is divided score, total points scope 0～18 minute, total points is high more, and sleep quality is poor more.
Sleep quality index questionnaire
According to above-mentioned sleep quality index questionnaire, concrete scoring rule is as described below:
Sleep quality: sleep quality is divided into, better, relatively poor and very poor 4 grades, and wherein good do not wake up night for sleeping fast, and few dream was counted 0 fen; Be preferably sleeping very fast, night, idol was waken up, and than dreaminess, counted 1 fen; Relatively poor is sleeping difficulty, more easily wakes up night or easy early awakening, and dreaminess was counted 2 fens; Very poor is difficulty falling asleep, easily wakes up night or easy early awakening, and many nightmares were counted 3 fens.
Time for falling asleep:
Calculate the score of the sleeping time that needs usually earlier, sleeping time "≤15 minutes " meter that needs usually 0 minute, the sleeping time " 16-30 branch " that needs usually counted 1 fen, was " 31-60 " meter 2 minutes when the sleeping time that needs usually, time " 〉=60 minutes " meter that needs usually when falling asleep 3 minutes; Calculate the score of the back 30 minutes wakeful situations of going to bed again, go to bed and counted 0 fen when wakeful situation was for " nothing " in back 30 minutes, the back 30 minutes wakeful situations of going to bed meter 1 minute during for "＜1 week/time ", the back 30 minutes wakeful situations of going to bed meter 2 minutes during, the back 30 minutes wakeful situations of going to bed meter 3 minutes during for " 〉=3 week/time " for " 1-2 week/time "; Then, the score of the sleeping time that needs usually and the score of the back 30 minutes wakeful situations of going to bed are added up, be divided into " 0 " meter 0 minute if add up, " 1-2 " meter 1 minute, " 3-4 " meter 2 minutes, " 5-6 " counted 3 fens.
Sleep efficiency: earlier deduct the time of going to bed and obtain the last time of bed with the time of getting up, reuse multiply by 100% divided by the time on the bed and obtain Sleep efficiency percent the actual length of one's sleep, when gained Sleep efficiency percent, counted 0 fen greater than 85% o'clock, meter is 1 minute when equaling 75-84%, meter is 2 minutes when equaling 65-74%, counts 3 fens less than 65% o'clock.
Sleep disorder: earlier in the above-mentioned sleep quality index questionnaire of meter the 5th ask in each score of asking of b to j, its scoring rule is, do not count 0 fen at previous month, a week, on every Mondays to twice 2 minutes, time above meter was 3 minutes on every Wendesdays less than once counting 1 fen; Each score of asking adds up with b to j again, if, add up and counted 0 fen when being divided into " 0 ", add up and counted 1 fen when being divided into " 1-9 ", add up and counted 2 fens when being divided into " 10-18 ", adding up is divided into " 19-27 " meter 3 minutes.
Hypnotic drug: in previous month, do not take the situation meter 0 minute that hypnotic helps sleep; Arranged less than once taking the situation meter 1 minute that hypnotic helps sleep one week; Have on every Mondays to taking the situation meter 2 minutes that hypnotic helps sleep for twice; Take the situation meter 3 minutes that hypnotic helps sleep more than having on every Wendesdays time.
Daytime function obstacle: calculate earlier and feel sleepy situation score, promptly, in previous month, drive, after meal or when being engaged in social activity, feel that sleepy situation do not count 0 fen, feel that sleepy one week of situation is less than once counting 1 fen, feel sleepy situation on every Mondays to twice 2 minutes, feel sleepy situation time above meter 3 minutes on every Wendesdays; Calculate to do things again and feel the score of deficient in energy situation, that is, in previous month, do things and feel deficient in energy situation, do not count 0 fen, meter 1 minute is arranged once in a while, meter 2 minutes are arranged sometimes, meter 3 minutes are often arranged; Then, will feel that sleepy situation score adds up with the score of feeling deficient in energy situation of doing things, be divided into " 0 " meter 0 minute, " 1-2 " meter 1 minute, " 3-4 " meter 2 minutes, " 5-6 " meter 3 minutes if add up.
Efficacy assessment standard: this standard reference " new Chinese medicine clinical research guideline " is formulated, score value * 100% before clinical symptoms integrated value improvement rate=(symptom integral value before the treatment-treatment back symptom integral value)/treatment.
Efficacy assessment standard:
Produce effects: symptom integral value improvement rate 〉=70%;
Effectively: symptom integral value improvement rate 〉=50%;
Invalid: symptom is not seen obvious improvement or is instead seen deterioration, symptom integral value improvement rate＜50%.
Statistical procedures: total data adopts SPSS 13.0 statistics softwares to carry out statistical analysis, measurement data mean ± standard deviation (x ± s) expression.Symptom score more all adopted the t check before and after two groups of experimenters treated, and two groups of experimenter's clinical efficacies relatively adopt X
2Check.
Result of the test
The clinical symptoms integration relatively sees Table 1 before and after foot bath group and the blank group; Curative effect relatively sees Table 2; The improvement of cardinal symptom sign relatively sees Table 3.As known from Table 2, bathing foot group effect organizes apparently higher than blank.N in table 1～table 3 represents number.
Clinical symptoms was marked relatively (x ± s divides) before and after table 1 a liang group was bathed foot
| Group | n | Before bathing foot | After bathing foot |
| Bathe the foot group | 30 | 12.41±6.05 | 7.48±4.73a?b |
| Blank group | 30 | 12.73±5.94 | 11.14±4.76 |
Foot bath is preceding compares with bath foot back: Pa＜0.05; Bathe foot group bath foot back and bathe the foot back relatively: Pb＜0.05 with blank the group
Table 2 liang group curative effect relatively
The foot group bathed by table 3 and blank group cardinal symptom sign is improved relatively
Foot bath is preceding compares with bath foot back: Pa＜0.05; Bathe foot group bath foot back and bathe the foot back relatively: Pb＜0.05 with blank the group
The specific embodiment
Embodiment 1
Prescription:
Crude drug: Rhizoma Chuanxiong 690g, Rhizoma Acori Graminei 1110g, Rhizoma Cyperi 690g, Caulis Polygoni Multiflori 690g, Radix Curcumae 690g, Poria 918g, Fructus Schisandrae Chinensis 690g, Radix Bupleuri 522g;
Adjuvant: citric acid 600g (in anhydride), sodium bicarbonate 780g, polyethylene glycol 6000 120g.
Method for making:
More than eight the flavor, get Rhizoma Chuanxiong power and be broken into fine powder, sieve; Seven flavor medicine materials such as all the other Rhizoma Acori Graminei decoct with water secondary, add for the first time 9 times of water gagings, add 9 times of water gagings, each 3 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.25-1.30 (60 ℃ of survey), adds 7/10 Rhizoma Chuanxiong fine powder, mixing, 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, sodium bicarbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid fine powder that adds, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Get residue Rhizoma Chuanxiong fine powder, add polyethylene glycol 6000, mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly.
Embodiment 2
Prescription:
Crude drug: Rhizoma Chuanxiong 300g, Rhizoma Acori Graminei 824g, Rhizoma Cyperi 685g, Caulis Polygoni Multiflori 893g, Radix Curcumae 1099g, Poria 1140g, Fructus Schisandrae Chinensis 688g, Radix Bupleuri 370g;
Adjuvant: citric acid 300g (in anhydride), fumaric acid 300g, sodium bicarbonate 480g, sodium carbonate 300g, polyethylene glycol 6000 100g, Macrogol 4000 40g.
Method for making:
More than eight the flavor, get Rhizoma Chuanxiong power and be broken into fine powder, sieve; Seven flavor medicine materials such as all the other Rhizoma Acori Graminei decoct with water secondary, add for the first time 10 times of water gagings, add 10 times of water gagings, each 1.5 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.25-1.30 (60 ℃ of survey), adds 7/10 Rhizoma Chuanxiong fine powder, mixing, 90 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 90 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 90 ℃ of dryings, No. two sieve granulate; Get residue Rhizoma Chuanxiong fine powder, add polyethylene glycol 6000, the Macrogol 4000 mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly.
Embodiment 3
Prescription:
Crude drug: Rhizoma Chuanxiong 300g, Rhizoma Acori Graminei 600g, Rhizoma Cyperi 506g, Caulis Polygoni Multiflori 722g, Radix Curcumae 938g, Poria 1445g, Fructus Schisandrae Chinensis 938g, Radix Bupleuri 550g;
Adjuvant: citric acid 300g (in anhydride), fumaric acid 300g, sodium bicarbonate 480g, sodium carbonate 300g, polyethylene glycol 6000 100g, Macrogol 4000 30g, sodium lauryl sulphate 10g, mannitol 100g, Oleum menthae (in right amount)
Method for making:
More than eight the flavor, get Rhizoma Chuanxiong power and be broken into fine powder, sieve; Seven flavor medicine materials such as all the other Rhizoma Acori Graminei decoct with water secondary, add for the first time 8 times of water gagings, add 8 times of water gagings, each 2 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.25-1.30 (60 ℃ of survey), adds 7/10 Rhizoma Chuanxiong fine powder, mixing, 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Get residue Rhizoma Chuanxiong fine powder, spray into Oleum menthae, add polyethylene glycol 6000, Macrogol 4000, sodium lauryl sulphate, the mannitol mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly.
Embodiment 4
Prescription:
Crude drug: Rhizoma Chuanxiong 538g, Rhizoma Acori Graminei 615g, Rhizoma Cyperi 308g, Caulis Polygoni Multiflori 538g, Radix Curcumae 769g, Poria 1275g, Fructus Schisandrae Chinensis 1200g, Radix Bupleuri 755g;
Adjuvant: citric acid 300g (in anhydride), fumaric acid 300g, potassium bicarbonate 480g, potassium carbonate 300g, polyethylene glycol 6000 100g, Polyethylene Glycol 5000 30g, sodium lauryl sulphate 10g, Pulvis Talci 10g, mannitol 100g, Oleum menthae, Oleum Rosae Rugosae (in right amount).
Method for making:
More than eight the flavor, get Rhizoma Chuanxiong power and be broken into fine powder, sieve; Seven flavor medicine materials such as all the other Rhizoma Acori Graminei decoct with water secondary, add for the first time 6 times of water gagings, add 6 times of water gagings, each 3 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.25-1.30 (60 ℃ of survey), adds 5/10 Rhizoma Chuanxiong fine powder, mixing, 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, potassium bicarbonate and potassium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds potassium bicarbonate and potassium carbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Get residue Rhizoma Chuanxiong fine powder, spray into Oleum menthae, Oleum Rosae Rugosae, add polyethylene glycol 6000, Polyethylene Glycol 5000, sodium lauryl sulphate, Pulvis Talci, the mannitol mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly.
Embodiment 5
Prescription:
Crude drug: Rhizoma Chuanxiong 805g, Rhizoma Acori Graminei 968g, Rhizoma Cyperi 323g, Caulis Polygoni Multiflori 323g, Radix Curcumae 565g, Poria 1065g, Fructus Schisandrae Chinensis 1049g, Radix Bupleuri 900g;
Adjuvant: citric acid 600g (in anhydride), sodium bicarbonate 1200g, polyethylene glycol 6000 120g.
Method for making:
More than eight the flavor, get Rhizoma Chuanxiong power and be broken into fine powder, sieve; Seven flavor medicine materials such as all the other Rhizoma Acori Graminei decoct with water secondary, add for the first time 8 times of water gagings, add 6 times of water gagings, each 3 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.25-1.30 (60 ℃ of survey), adds 7/10 Rhizoma Chuanxiong fine powder, mixing, 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, sodium bicarbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid fine powder that adds, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Get residue Rhizoma Chuanxiong fine powder, add Polyethylene Glycol 5000, mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly.
Embodiment 6
Prescription:
Crude drug: Rhizoma Chuanxiong 1060g, Rhizoma Acori Graminei 1304g, Rhizoma Cyperi 570g, Caulis Polygoni Multiflori 326g, Radix Curcumae 326g, Poria 798g, Fructus Schisandrae Chinensis 815g, Radix Bupleuri 800g;
Adjuvant: citric acid 300g (in anhydride), fumaric acid 300g, sodium bicarbonate 600g, sodium carbonate 600g, Polyethylene Glycol 5000 100g, Macrogol 4000 40g.
Method for making:
More than eight the flavor, get Rhizoma Chuanxiong power and be broken into fine powder, sieve; Seven flavor medicine materials such as all the other Rhizoma Acori Graminei decoct with water secondary, add for the first time 8 times of water gagings, add 9 times of water gagings, each 3 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.25-1.30 (60 ℃ of survey), adds 9/10 Rhizoma Chuanxiong fine powder, mixing, 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Get residue Rhizoma Chuanxiong fine powder, add Polyethylene Glycol 5000, the Macrogol 4000 mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly.
Embodiment 7
Prescription:
Crude drug: Rhizoma Chuanxiong 1200g, Rhizoma Acori Graminei 1548g, Rhizoma Cyperi 773g, Caulis Polygoni Multiflori 542g, Radix Curcumae 310g, Poria 495g, Fructus Schisandrae Chinensis 543g, Radix Bupleuri 588g;
Adjuvant: citric acid 300g (in anhydride), fumaric acid 300g, sodium bicarbonate 580g, sodium carbonate 400g, polyethylene glycol 6000 100g, Polyethylene Glycol 5000 30g, sodium lauryl sulphate 10g, mannitol 100g, Oleum menthae, Oleum Rosae Rugosae (in right amount).
Method for making:
More than eight the flavor, get Rhizoma Chuanxiong power and be broken into fine powder, sieve; Seven flavor medicine materials such as all the other Rhizoma Acori Graminei decoct with water secondary, add for the first time 8 times of water gagings, add 6 times of water gagings, each 3 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.25-1.30 (60 ℃ of survey), adds 7/10 Rhizoma Chuanxiong fine powder, mixing, 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Get residue Rhizoma Chuanxiong fine powder, spray into Oleum menthae, Oleum Rosae Rugosae, add polyethylene glycol 6000, Polyethylene Glycol 5000, sodium lauryl sulphate, the mannitol mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly.
Embodiment 8
Prescription:
Crude drug: Rhizoma Chuanxiong 937g, Rhizoma Acori Graminei 1730g, Rhizoma Cyperi 938g, Caulis Polygoni Multiflori 720g, Radix Curcumae 505g, Poria 480g, Fructus Schisandrae Chinensis 300g, Radix Bupleuri 389g;
Adjuvant: citric acid 400g (in anhydride), fumaric acid 300g, sodium bicarbonate 580g, sodium carbonate 400g, polyethylene glycol 6000 100g, Macrogol 4000 30g, sodium lauryl sulphate 10g, Pulvis Talci 10g, mannitol 100g, Oleum menthae (in right amount).
Method for making:
More than eight the flavor, get Rhizoma Chuanxiong power and be broken into fine powder, sieve; Seven flavor medicine materials such as all the other Rhizoma Acori Graminei decoct with water secondary, add for the first time 10 times of water gagings, add 10 times of water gagings, each 3 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.25-1.30 (60 ℃ of survey), adds 7/10 Rhizoma Chuanxiong fine powder, mixing, 60 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 60 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 60 ℃ of dryings, No. two sieve granulate; Get residue Rhizoma Chuanxiong fine powder, spray into Oleum menthae, add polyethylene glycol 6000, Macrogol 4000, sodium lauryl sulphate, Pulvis Talci, the mannitol mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly.
Embodiment 9
Prescription:
Crude drug: Rhizoma Chuanxiong 693g, Rhizoma Acori Graminei 1386g, Rhizoma Cyperi 1108g, Caulis Polygoni Multiflori 901g, Radix Curcumae 693g, Poria 679g, Fructus Schisandrae Chinensis 300g, Radix Bupleuri 240g;
Adjuvant: Oleum menthae (in right amount), citric acid 1200g (in anhydride), sodium bicarbonate 600g, polyethylene glycol 6000 120g.
Method for making:
More than eight the flavor, get Rhizoma Chuanxiong power and be broken into fine powder, sieve; Seven flavor medicine materials such as all the other Rhizoma Acori Graminei decoct with water secondary, add for the first time 8 times of water gagings, add 6 times of water gagings, each 3 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.25-1.30 (60 ℃ of survey), adds 7/10 Rhizoma Chuanxiong fine powder, mixing, 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, sodium bicarbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid fine powder that adds, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Get residue Rhizoma Chuanxiong fine powder, spray into Oleum menthae, add polyethylene glycol 6000, mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly.
Embodiment 10
Prescription:
Crude drug: Rhizoma Chuanxiong 473g, Rhizoma Acori Graminei 1082g, Rhizoma Cyperi 879g, Caulis Polygoni Multiflori 1082g, Radix Curcumae 879g, Poria 892g, Fructus Schisandrae Chinensis 473g, Radix Bupleuri 240g;
Adjuvant: citric acid 600g (in anhydride), fumaric acid 600g, sodium bicarbonate 300g, sodium carbonate 300g, polyethylene glycol 6000 100g, Polyethylene Glycol 5000 40g.
Method for making:
More than eight the flavor, get Rhizoma Chuanxiong power and be broken into fine powder, sieve; Seven flavor medicine materials such as all the other Rhizoma Acori Graminei decoct with water secondary, add for the first time 10 times of water gagings, add 10 times of water gagings, each 3 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.25-1.30 (60 ℃ of survey), adds 7/10 Rhizoma Chuanxiong fine powder, mixing, 85 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 85 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 85 ℃ of dryings, No. two sieve granulate; Get residue Rhizoma Chuanxiong fine powder, add polyethylene glycol 6000, Polyethylene Glycol 5000 mixings are crossed 80 mesh sieves, add above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly.
Embodiment 11
Prescription:
Crude drug: Rhizoma Chuanxiong 465g, Rhizoma Acori Graminei 800g, Rhizoma Cyperi 667g, Caulis Polygoni Multiflori 867g, Radix Curcumae 1067g, Poria 1107g, Fructus Schisandrae Chinensis 667g, Radix Bupleuri 360g;
Adjuvant: citric acid 400g (in anhydride), fumaric acid 800g, sodium bicarbonate 200g, sodium carbonate 400g, polyethylene glycol 6000 100g, Macrogol 4000 30g, sodium lauryl sulphate 10g, mannitol 100g, Oleum menthae (in right amount).
Method for making:
More than eight the flavor, get Rhizoma Chuanxiong power and be broken into fine powder, sieve; Seven flavor medicine materials such as all the other Rhizoma Acori Graminei decoct with water secondary, add for the first time 8 times of water gagings, add 10 times of water gagings, each 3 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.25-1.30 (60 ℃ of survey), adds 7/10 Rhizoma Chuanxiong fine powder, mixing, 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Get residue Rhizoma Chuanxiong fine powder, spray into Oleum menthae, add polyethylene glycol 6000, Macrogol 4000, sodium lauryl sulphate, the mannitol mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly.
Embodiment 12
Prescription:
Crude drug: Rhizoma Chuanxiong 300g, Rhizoma Acori Graminei 828g, Rhizoma Cyperi 483g, Caulis Polygoni Multiflori 690g, Radix Curcumae 897g, Poria 1380g, Fructus Schisandrae Chinensis 897g, Radix Bupleuri 525g;
Adjuvant: citric acid 900g (in anhydride), fumaric acid 300g, sodium bicarbonate 100g, sodium carbonate 500g, Polyethylene Glycol 5000 100g, Macrogol 4000 30g, sodium lauryl sulphate 10g, Pulvis Talci 10g, mannitol 100g, Oleum menthae (in right amount).
Method for making:
More than eight the flavor, get Rhizoma Chuanxiong power and be broken into fine powder, sieve; Seven flavor medicine materials such as all the other Rhizoma Acori Graminei decoct with water secondary, add for the first time 8 times of water gagings, add 8 times of water gagings, each 3 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.25-1.30 (60 ℃ of survey), adds 7/10 Rhizoma Chuanxiong fine powder, mixing, 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Get residue Rhizoma Chuanxiong fine powder, spray into Oleum menthae, add Polyethylene Glycol 5000, Macrogol 4000, sodium lauryl sulphate, Pulvis Talci, the mannitol mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly.
Embodiment 13
Prescription:
Crude drug: Rhizoma Chuanxiong 515g, Rhizoma Acori Graminei 600g, Rhizoma Cyperi 515g, Caulis Polygoni Multiflori 515g, Radix Curcumae 736g, Poria 1221g, Fructus Schisandrae Chinensis 1177g, Radix Bupleuri 721g;
Adjuvant: citric acid 900g (in anhydride), sodium bicarbonate 900g, Polyethylene Glycol 5000 120g.
Method for making:
More than eight the flavor, get Rhizoma Chuanxiong power and be broken into fine powder, sieve; Seven flavor medicine materials such as all the other Rhizoma Acori Graminei decoct with water secondary, add for the first time 9 times of water gagings, add 6 times of water gagings, each 3 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.25-1.30 (60 ℃ of survey), adds 7/10 Rhizoma Chuanxiong fine powder, mixing, 70 ℃ of dryings are ground into fine powder, sieve.Citric acid, sodium bicarbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid fine powder that adds, mixing is made granule, 70 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Get residue Rhizoma Chuanxiong fine powder, add Polyethylene Glycol 5000, mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly.
Embodiment 14
Prescription:
Crude drug: Rhizoma Chuanxiong 770g, Rhizoma Acori Graminei 925g, Rhizoma Cyperi 308g, Caulis Polygoni Multiflori 540g, Radix Curcumae 540g, Poria 1017g, Fructus Schisandrae Chinensis 1000g, Radix Bupleuri 900g;
Adjuvant: citric acid 450g (in anhydride), fumaric acid 450g, sodium bicarbonate 480g, sodium carbonate 420g, polyethylene glycol 6000 100g, Polyethylene Glycol 5000 40g.
Method for making:
More than eight the flavor, get Rhizoma Chuanxiong power and be broken into fine powder, sieve; Seven flavor medicine materials such as all the other Rhizoma Acori Graminei decoct with water secondary, add for the first time 8 times of water gagings, add 10 times of water gagings, each 3 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.25-1.30 (60 ℃ of survey), adds 7/10 Rhizoma Chuanxiong fine powder, mixing, 90 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 90 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 90 ℃ of dryings, No. two sieve granulate; Get residue Rhizoma Chuanxiong fine powder, add polyethylene glycol 6000, Polyethylene Glycol 5000 mixings are crossed 80 mesh sieves, add above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly.
Embodiment 15
Prescription:
Crude drug: Rhizoma Chuanxiong 1020g, Rhizoma Acori Graminei 1254g, Rhizoma Cyperi 548g, Caulis Polygoni Multiflori 313g, Radix Curcumae 548g, Poria 767g, Fructus Schisandrae Chinensis 783g, Radix Bupleuri 767g;
Adjuvant: citric acid 600g (in anhydride), fumaric acid 300g, sodium bicarbonate 600g, sodium carbonate 300g, polyethylene glycol 6000 100g, Macrogol 4000 30g, sodium lauryl sulphate 10g, mannitol 100g, Oleum menthae (in right amount).
Method for making:
More than eight the flavor, get Rhizoma Chuanxiong power and be broken into fine powder, sieve; Seven flavor medicine materials such as all the other Rhizoma Acori Graminei decoct with water secondary, add for the first time 10 times of water gagings, add 8 times of water gagings, each 3 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.25-1.30 (60 ℃ of survey), adds 7/10 Rhizoma Chuanxiong fine powder, mixing, 90 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 90 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 90 ℃ of dryings, No. two sieve granulate; Get residue Rhizoma Chuanxiong fine powder, spray into Oleum menthae, add polyethylene glycol 6000, Macrogol 4000, sodium lauryl sulphate, the mannitol mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly.
Embodiment 16
Prescription:
Crude drug: Rhizoma Chuanxiong 1178g, Rhizoma Acori Graminei 1474g, Rhizoma Cyperi 736g, Caulis Polygoni Multiflori 515g, Radix Curcumae 300g, Poria 722g, Fructus Schisandrae Chinensis 515g, Radix Bupleuri 560g;
Adjuvant: citric acid 500g (in anhydride), fumaric acid 400g, sodium bicarbonate 4000g, sodium carbonate 500g, polyethylene glycol 6000 100g, Macrogol 4000 30g, sodium lauryl sulphate 10g, Pulvis Talci 10g, mannitol 100g, Oleum menthae (in right amount).
Method for making:
More than eight the flavor, get Rhizoma Chuanxiong power and be broken into fine powder, sieve; Seven flavor medicine materials such as all the other Rhizoma Acori Graminei decoct with water secondary, add for the first time 10 times of water gagings, add 9 times of water gagings, each 2 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.25-1.30 (60 ℃ of survey), adds 6/10 Rhizoma Chuanxiong fine powder, mixing, 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Get residue Rhizoma Chuanxiong fine powder, spray into Oleum menthae, add polyethylene glycol 6000, Polyethylene Glycol 5000, sodium lauryl sulphate, Pulvis Talci, the mannitol mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly.
Embodiment 17
Prescription:
Crude drug: Rhizoma Chuanxiong 904g, Rhizoma Acori Graminei 1668g, Rhizoma Cyperi 904g, Caulis Polygoni Multiflori 695g, Radix Curcumae 487g, Poria 480g, Fructus Schisandrae Chinensis 487g, Radix Bupleuri 375g;
Adjuvant: Oleum menthae (in right amount), fumaric acid 600g, sodium bicarbonate 1200g, polyethylene glycol 6000 120g.
Method for making:
More than eight the flavor, get Rhizoma Chuanxiong power and be broken into fine powder, sieve; Seven flavor medicine materials such as all the other Rhizoma Acori Graminei decoct with water secondary, add for the first time 10 times of water gagings, add 7 times of water gagings, each 2.5 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.25-1.30 (60 ℃ of survey), adds 9/10 Rhizoma Chuanxiong fine powder, mixing, 80 ℃ of dryings are ground into fine powder, sieve.Fumaric acid, sodium bicarbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a fumaric acid fine powder that adds, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Get residue Rhizoma Chuanxiong fine powder, spray into Oleum menthae, add polyethylene glycol 6000, mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly.
Embodiment 18
Prescription:
Crude drug: Rhizoma Chuanxiong 677g, Rhizoma Acori Graminei 1354g, Rhizoma Cyperi 1083g, Caulis Polygoni Multiflori 880g, Radix Curcumae 677g, Poria 663g, Fructus Schisandrae Chinensis 300g, Radix Bupleuri 366g;
Adjuvant: citric acid 300g (in anhydride), fumaric acid 300g, sodium bicarbonate 600g, sodium carbonate 600g, polyethylene glycol 6000 100g, Polyethylene Glycol 5000 40g.
Method for making:
More than eight the flavor, get Rhizoma Chuanxiong power and be broken into fine powder, sieve; Seven flavor medicine materials such as all the other Rhizoma Acori Graminei decoct with water secondary, add for the first time 8 times of water gagings, add 8 times of water gagings, each 3 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.25-1.30 (60 ℃ of survey), adds 5/10 Rhizoma Chuanxiong fine powder, mixing, 88 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 88 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 88 ℃ of dryings, No. two sieve granulate; Get residue Rhizoma Chuanxiong fine powder, add polyethylene glycol 6000, Polyethylene Glycol 5000 mixings are crossed 80 mesh sieves, add above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly.
Embodiment 19
Prescription:
Crude drug: Rhizoma Chuanxiong 653g, Rhizoma Acori Graminei 1045g, Rhizoma Cyperi 849g, Caulis Polygoni Multiflori 1045g, Radix Curcumae 849g, Poria 862g, Fructus Schisandrae Chinensis 457g, Radix Bupleuri 240g;
Adjuvant: citric acid 100g (in anhydride), fumaric acid 500g, sodium bicarbonate 900g, sodium carbonate 300g, polyethylene glycol 6000 100g, Macrogol 4000 30g, sodium lauryl sulphate 10g, mannitol 100g, Oleum menthae (in right amount).
Method for making:
More than eight the flavor, get Rhizoma Chuanxiong power and be broken into fine powder, sieve; Seven flavor medicine materials such as all the other Rhizoma Acori Graminei decoct with water secondary, add for the first time 9 times of water gagings, add 7 times of water gagings, each 3 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.25-1.30 (60 ℃ of survey), adds 8/10 Rhizoma Chuanxiong fine powder, mixing, 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Get residue Rhizoma Chuanxiong fine powder, spray into Oleum menthae, add polyethylene glycol 6000, Macrogol 4000, sodium lauryl sulphate, the mannitol mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly.
Embodiment 20
Prescription:
Crude drug: Rhizoma Chuanxiong 447g, Rhizoma Acori Graminei 1021g, Rhizoma Cyperi 638g, Caulis Polygoni Multiflori 830g, Radix Curcumae 1021g, Poria 1060g, Fructus Schisandrae Chinensis 638g, Radix Bupleuri 345g;
Adjuvant: citric acid 500g (in anhydride), fumaric acid 100g, sodium bicarbonate 200g, sodium carbonate 1000g, polyethylene glycol 6000 100g, Polyethylene Glycol 5000 30g, sodium lauryl sulphate 10g, Pulvis Talci 10g, mannitol 100g, Oleum menthae (in right amount).
Method for making:
More than eight the flavor, get Rhizoma Chuanxiong power and be broken into fine powder, sieve; Seven flavor medicine materials such as all the other Rhizoma Acori Graminei decoct with water secondary, add for the first time 8 times of water gagings, add 6 times of water gagings, each 3 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.25-1.30 (60 ℃ of survey), adds 7/10 Rhizoma Chuanxiong fine powder, mixing, 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Get residue Rhizoma Chuanxiong fine powder, spray into Oleum menthae, add polyethylene glycol 6000, Polyethylene Glycol 5000, sodium lauryl sulphate, Pulvis Talci, the mannitol mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly.
Embodiment 21
Prescription:
Crude drug: Rhizoma Chuanxiong 300g, Rhizoma Acori Graminei 799g, Rhizoma Cyperi 666g, Caulis Polygoni Multiflori 666g, Radix Curcumae 866g, Poria 1332g, Fructus Schisandrae Chinensis 866g, Radix Bupleuri 505g;
Adjuvant: citric acid 1200g (in anhydride), sodium bicarbonate 800g, Macrogol 4000 120g.
Method for making:
More than eight the flavor, get Rhizoma Chuanxiong power and be broken into fine powder, sieve; Seven flavor medicine materials such as all the other Rhizoma Acori Graminei decoct with water secondary, add for the first time 8 times of water gagings, add 6 times of water gagings, each 3 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.25-1.30 (60 ℃ of survey), adds 7/10 Rhizoma Chuanxiong fine powder, mixing, 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, sodium bicarbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid fine powder that adds, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Get residue Rhizoma Chuanxiong fine powder, add Macrogol 4000, mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly.
Embodiment 22
Prescription:
Crude drug: Rhizoma Chuanxiong 495g, Rhizoma Acori Graminei 600g, Rhizoma Cyperi 495g, Caulis Polygoni Multiflori 707g, Radix Curcumae 707g, Poria 1173g, Fructus Schisandrae Chinensis 1130g, Radix Bupleuri 693g;
Adjuvant: citric acid 700g (in anhydride), fumaric acid 500g, sodium bicarbonate 480g, sodium carbonate 400g, polyethylene glycol 6000 100g, Macrogol 4000 40g.
Method for making:
More than eight the flavor, get Rhizoma Chuanxiong power and be broken into fine powder, sieve; Seven flavor medicine materials such as all the other Rhizoma Acori Graminei decoct with water secondary, add for the first time 8 times of water gagings, add 6.5 times of water gagings, each 3 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.25-1.30 (60 ℃ of survey), adds 7/10 Rhizoma Chuanxiong fine powder, mixing, 70 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 70 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 70 ℃ of dryings, No. two sieve granulate; Get residue Rhizoma Chuanxiong fine powder, add Polyethylene Glycol 5000, the Macrogol 4000 mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly.
Embodiment 23
Prescription:
Crude drug: Rhizoma Chuanxiong 738g, Rhizoma Acori Graminei 886g, Rhizoma Cyperi 300g, Caulis Polygoni Multiflori 517g, Radix Curcumae 738g, Poria 975g, Fructus Schisandrae Chinensis 960g, Radix Bupleuri 886g;
Adjuvant: citric acid 800g (in anhydride), fumaric acid 400g, sodium bicarbonate 400g, sodium carbonate 800g, polyethylene glycol 6000 100g, Macrogol 4000 30g, sodium lauryl sulphate 10g, mannitol 100g, Oleum menthae (in right amount).
Method for making:
More than eight the flavor, get Rhizoma Chuanxiong power and be broken into fine powder, sieve; Seven flavor medicine materials such as all the other Rhizoma Acori Graminei decoct with water secondary, add for the first time 8 times of water gagings, add 6 times of water gagings, each 3 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.25-1.30 (60 ℃ of survey), adds 9/10 Rhizoma Chuanxiong fine powder, mixing, 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Get residue Rhizoma Chuanxiong fine powder, spray into Oleum menthae, add polyethylene glycol 6000, Macrogol 4000, sodium lauryl sulphate, the mannitol mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly.
Embodiment 24
Prescription:
Crude drug: Rhizoma Chuanxiong 975g, Rhizoma Acori Graminei 1200g, Rhizoma Cyperi 525g, Caulis Polygoni Multiflori 300g, Radix Curcumae 525g, Poria 990g, Fructus Schisandrae Chinensis 750g, Radix Bupleuri 735g;
Adjuvant: citric acid 700g (in anhydride), fumaric acid 300g, sodium bicarbonate 700g, sodium carbonate 300g, polyethylene glycol 6000 100g, Macrogol 4000 30g, sodium lauryl sulphate 10g, Pulvis Talci 10g, mannitol 100g, Oleum menthae (in right amount).
Method for making:
More than eight the flavor, get Rhizoma Chuanxiong power and be broken into fine powder, sieve; Seven flavor medicine materials such as all the other Rhizoma Acori Graminei decoct with water secondary, add for the first time 8 times of water gagings, add 7.5 times of water gagings, each 3 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.25-1.30 (60 ℃ of survey), adds 8/10 Rhizoma Chuanxiong fine powder, mixing, 90 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 90 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 90 ℃ of dryings, No. two sieve granulate; Get residue Rhizoma Chuanxiong fine powder, spray into Oleum menthae, add polyethylene glycol 6000, Macrogol 4000, sodium lauryl sulphate, Pulvis Talci, the mannitol mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly.
Claims (4)
1. foot-bath effervescent tablet that improves sleep, this foot-bath effervescent tablet mainly is made up of active ingredient, effervescent excipient and binding agent, it is characterized in that described active ingredient is to be made up of 5%～20% the Rhizoma Chuanxiong power and the water extract of following crude drug by the percentage by weight of crude drug:
Rhizoma Acori Graminei 10%～30%, Rhizoma Cyperi 5%～20%, Caulis Polygoni Multiflori 5%～20%, Radix Curcumae 5%～20%, Poria 8%～25%, Fructus Schisandrae Chinensis 5%～20%, Radix Bupleuri 4%～15%.
2. a kind of foot-bath effervescent tablet that improves sleep according to claim 1 is characterized in that, described active ingredient is to be made up of 8.75%～16.25% the Rhizoma Chuanxiong power and the water extract of following crude drug by the percentage by weight of crude drug:
Rhizoma Acori Graminei 15.00%～25.00%, Rhizoma Cyperi 8.75%～16.25%, Caulis Polygoni Multiflori 8.75%～16.25%, Radix Curcumae 8.75%～16.25%, Poria 12.25%～20.75%, Fructus Schisandrae Chinensis 8.75%～16.25%, Radix Bupleuri 6.75%～12.25%.
3. a kind of foot-bath effervescent tablet that improves sleep according to claim 2, it is characterized in that, described active ingredient is to be made up of 11.5% the Rhizoma Chuanxiong power and the water extract of following crude drug by the percentage by weight of crude drug: Rhizoma Acori Graminei 18.5%, Rhizoma Cyperi 11.5%, Caulis Polygoni Multiflori 11.5%, Radix Curcumae 11.5%, Poria 15.3%, Fructus Schisandrae Chinensis 11.5%, Radix Bupleuri 8.7%.
4. according to claim 1,2 or 3 described a kind of foot-bath effervescent tablets that improve sleep, it is characterized in that described water extract is prepared by following method:
Get Rhizoma Acori Graminei, Rhizoma Cyperi, Caulis Polygoni Multiflori, Radix Curcumae, Poria, Fructus Schisandrae Chinensis and Radix Bupleuri by proportioning, add 6-10 times of water gaging earlier, decocted 1.5-3 hour, filter; Filtering residue adds 6-10 times of water gaging again, decocts 1.5-3 hour, filters; Merge filtrate twice, concentrate, be drying to obtain.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2010101797751A CN101837109B (en) | 2010-05-17 | 2010-05-17 | Foot-bath effervescent tablet for improving sleep |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2010101797751A CN101837109B (en) | 2010-05-17 | 2010-05-17 | Foot-bath effervescent tablet for improving sleep |
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| CN101837109B true CN101837109B (en) | 2011-07-13 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103054044B (en) * | 2012-12-26 | 2014-09-03 | 北京康比特体育科技股份有限公司 | Sleep-improving health food composition |
| CN104887564A (en) * | 2015-05-14 | 2015-09-09 | 北京同仁堂安徽中药材有限公司 | Health care footbath powder for invigorating blood circulation and fending off cold and preparation method thereof |
| CN115518135A (en) * | 2021-06-12 | 2022-12-27 | 左点实业（湖北）有限公司 | Health-care foot bath liquid and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1123137A (en) * | 1994-11-17 | 1996-05-29 | 赵新胜 | "Mengtianxin"-natural health-care bath lotion capable of permeating skin and preparation thereof |
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2010
- 2010-05-17 CN CN2010101797751A patent/CN101837109B/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1123137A (en) * | 1994-11-17 | 1996-05-29 | 赵新胜 | "Mengtianxin"-natural health-care bath lotion capable of permeating skin and preparation thereof |
Non-Patent Citations (1)
| Title |
|---|
| 刘均仪等.中医药治疗失眠的研究进展.《中西医结合心脑血管病杂志》.2008,第6卷(第11期),1332-1335. * |
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