CN113577137B - Traditional Chinese medicine composition for treating acne and preparation method and application thereof - Google Patents
Traditional Chinese medicine composition for treating acne and preparation method and application thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
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- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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Abstract
The invention provides a traditional Chinese medicine composition for treating acne, a preparation method of the traditional Chinese medicine composition and application of the traditional Chinese medicine composition in preparation of a medicine for treating acne, wherein the traditional Chinese medicine composition is composed of pure traditional Chinese medicines such as mulberry leaves, caltrops and the like.
Description
Technical Field
The invention belongs to the technical field of acne prevention and treatment, and particularly relates to a traditional Chinese medicine composition containing mulberry leaves, a preparation method thereof and application of the traditional Chinese medicine composition in acne treatment.
Background
Acne, commonly known as "whelk" or "acne", is a chronic inflammatory skin disease caused by obstruction of hair follicles and sebaceous glands and inflammation. The disease is common in young people, and after the disease enters the puberty stage, the level of in-vivo sex hormone is increased, so that the hyperplasia and the hypertrophy of sebaceous glands are promoted, the secretion of sebaceous glands is increased, sebum is accumulated, the follicular orifice is blocked, and the increased sebum cannot be discharged in time, so that acne is formed. However, the generation of acne is not completely limited by the age groups, and people in almost all ages, from children to adults, can develop diseases, and high fat, high sugar diet, long-term constipation and the like are important causes of acne. Traditional Chinese medicine considers that excessive eating of oily and spicy food, accumulated heat of spleen and stomach and damp generation, invasion of exogenous evil to skin cause acne, and in addition, the excessive working pressure, mental stress cause qi depression and fire transformation, too little exercise quantity and stay up at night, cause qi and blood deficiency and qi and blood stasis are also important reasons.
As acne usually occurs on the face, chest and back parts of patients, the appearance is affected. If not treated in time, local pigmentation and even scars can be caused, which has adverse effects on the psychological and social aspects of the patient. The traditional acne treatment method is more, but the effect is not satisfactory, and the external medicines such as tretinoin, benzoyl peroxide, adapalene and the like have the problems of slow effect, long-term use and easy local reaction; the oral medicine such as antibiotics, compound acetic acid cycloacetone tablet and the like has great side effect and can induce other skin diseases.
While the traditional Chinese medicine in China accumulates very abundant experiences in the aspect of acne treatment, the traditional Chinese medicine considers that the incidence of acne and damp-heat cause internal toxin accumulation, but the internal toxin is present, and the external surface is hot. Therefore, in clinical application, the method for eliminating damp-heat and internal toxin is often used for both principal and secondary aspect, and the purpose of eliminating acne is achieved by expelling toxin from medicinal materials with damp-heat.
The present invention combines the kuh-seng with the functions of expelling toxin and removing dampness and the mulberry leaf with the functions of clearing heat and detoxicating, and is matched with the caltrop with the functions of activating blood and expelling wind, so that the acne is naturally eliminated by playing the effects of expelling wind, dampness and heat.
Disclosure of Invention
The present invention aims to solve at least one of the technical problems existing in the prior art. Therefore, the invention provides a traditional Chinese medicine composition for preventing and treating acne.
The invention also provides a preparation method of the traditional Chinese medicine composition.
In addition, the invention also provides application of the traditional Chinese medicine composition.
The invention provides a traditional Chinese medicine composition for treating acne, which is prepared from the following raw materials in parts by weight: 20-70 parts of mulberry leaf, 30-80 parts of caltrop, 10-30 parts of sea buckthorn and 1-15 parts of kuh-seng.
In order to achieve a better treatment effect, the traditional Chinese medicine composition is preferably prepared from the following raw materials in parts by weight: 35-50 parts of mulberry leaf, 40-60 parts of caltrop, 15-25 parts of sea buckthorn and 3-10 parts of kuh-seng.
In order to optimize the treatment effect, more preferably, the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 40 parts of mulberry leaf, 50 parts of caltrop, 20 parts of sea buckthorn and 5 parts of kuh-seng.
The invention also aims at providing a method for preparing a medicine for treating acne, and the preparation method of the traditional Chinese medicine composition for treating acne is as follows:
A. Weighing folium Mori, fructus Tribuli, fructus Hippophae and radix Sophorae Flavescentis according to the ratio;
B. pulverizing the taken lightyellow sophora root with a balance weight, adding 5-10 times of water for soaking, filtering, and respectively collecting filtrate and filter residues for later use;
C. adding ethanol into the lightyellow sophora root filter residues obtained in the step B, carrying out reflux extraction, standing for 24 hours, filtering, and recovering ethanol from the filtrate for later use;
D. reflux extracting folium Mori juice for later use after Sang Shezha juice, folium Mori residue, fructus Tribuli and fructus Hippophae with 3-12 times of water for 2-5 times, each time for 0.5-3 hr, filtering, and keeping filtrate for later use;
E. Mixing the filtrate obtained in step B, C and D with the mulberry leaf juice obtained in step B, concentrating, vacuum drying to obtain dry extract, adding corresponding medicinal adjuvants, and mixing to obtain other oral medicinal preparation or external preparation.
B, crushing the radix sophorae flavescentis into particles which are sieved by a 60-80-mesh sieve, soaking for 3-5 hours, preferably crushing the radix sophorae flavescentis into particles which are sieved by a 70-mesh sieve, and soaking for 4 hours;
The concentration of the ethanol in the step C is 50-75%, the feed liquid ratio of the filter residue to the ethanol is 1:3-10 times, the extraction is carried out for 2-4 times, each time for 1-3 hours, the preferable concentration of the ethanol is 60-70%, the feed liquid ratio of the filter residue to the ethanol is 1:5-8 times, the extraction is carried out for 3 times, and each time for 2 hours.
And D, reflux-extracting the mulberry leaf residue, the caltrop and the sea buckthorn with 5-8 times of water for 3 times, wherein each time of extraction is 1-2 hours, preferably, reflux-extracting the mulberry leaf, the caltrop and the sea buckthorn with 6 times of water for 3 times, and each time of extraction is 1.5 hours.
The oral pharmaceutical preparation is any one of oral dosage forms such as tablets, capsules, dripping pills, buccal tablets, granules, pills, powder and the like. The active ingredients of the medicine can be added with various conventional auxiliary materials such as disintegrating agents, lubricants, adhesives and the like required by preparing different dosage forms, and can be prepared into any common oral dosage form such as pills, powder, tablets, capsules, oral liquid and the like by a conventional traditional Chinese medicine preparation method.
The external preparation is any external preparation form such as liniment, cream, spray, gel, lotion and the like. The active ingredients of the medicine can be added with various conventional auxiliary materials such as lubricant, adhesive and the like required by preparing different dosage forms, and can be prepared into any common external dosage form such as powder, lotion, ointment, spray, gel, cream and the like by a conventional traditional Chinese medicine preparation method.
The medicine of the invention can be prepared into any conventional preparation by adopting a conventional method of a traditional Chinese medicine preparation. For example, the raw materials can be ground into powder and mixed uniformly to prepare powder for administration; or decocting the above materials with water, and concentrating the decoction; in order to make each raw material of the drug exert better efficacy, it is preferable to extract turmeric and the like in the raw material drug specifically, for example, volatile oil and the like. None of these should be used to limit the scope of the present invention.
Another object of the present invention is to provide a pharmaceutical composition obtained by the above preparation method, which is an application in preparing a medicine for treating acne.
The traditional Chinese medicine composition is formed by combining mulberry leaves, caltrops, sea buckthorn and kuh-seng. Wherein, the mulberry leaf is cold in nature, sweet and bitter in taste, and enters lung and liver meridians. The Chinese medicinal composition has the effects of dispelling wind and heat, clearing lung and moistening dryness, is a monarch drug in the recipe, has pungent and bitter taste and slight warm nature, enters liver meridian, is firstly carried out in Shennong's herbal meridian, is listed as an upper product, has the effects of soothing liver and relieving depression, activating blood and dispelling wind and relieving itching, can promote blood circulation and relieve depression while helping mulberry leaves to dispel wind and heat and dissipate heat, and can relieve symptoms and itching, and is a ministerial drug in the recipe; hippophae rhamnoides is a Mongolian medicine with warm nature and sour and astringent taste. The traditional Chinese medicine has the effects of invigorating spleen channel, stomach channel, lung channel and heart channel, and is considered by modern pharmacology to have the effects of activating blood and dissolving stasis and promoting ulcer healing, so that the traditional Chinese medicine is favorable for promoting blood circulation of caltrop, and can promote acne wound healing, and the diseases of kuh-seng, such as bitter bone, radix sophorae flavescentis, and the like, such as clearing heat and drying dampness, dispelling wind and killing parasites, skin itch, yin sore and the like; the kuh-seng has the effects of clearing heat and detoxicating, promoting blood circulation and dispelling wind, and promoting diuresis and resolving masses, so the sea-buckthorn and the kuh-seng are used as adjuvant drugs. The medicines are combined together, so that the medicine has good curative effect on treating acne and less side effect, and is worthy of clinical popularization and use.
Test example one:
In order to verify the application of the composition in preparing the medicine for treating acne, the inventor performs clinical pre-experiments in a first people hospital in Liuyang, and the specific conditions are as follows:
1. Case selection
All cases were adult patients diagnosed with acne at the clinic, who had not been orally administered or topically administered antibiotics or corticosteroids for 1 week, and who agreed to receive this therapy. The pregnant women and the patients with serious systemic diseases can not finish the treatment course due to reasons.
2. Case profile
A total of 120 patients were selected for this clinical trial, 58 male patients and 62 female patients. The ages are 13-30 years, average 20.6 years, the course of disease is 4 weeks-3 years, average 1.4 years.
3. Data equalization verification
The cases were randomly divided into 2 groups, treatment and control. 60 cases for each group. The two groups of patients have no significance in terms of sex, age, disease course, disease period, acne distribution and the like, and are comparable.
4. Research method
Random, control study.
5. Therapeutic method
The Chinese medicinal composition preparation of the embodiment 1 is administered to patients in treatment groups, 3 times per day, 4 granules each time, and 1 week as 1 treatment course. The control group of patients were given tanshinone capsules (Hebei Xinglong Hill pharmaceutical Co., ltd.) 3 times per day, 4 granules each time.
6. Results
1. Comparison of clinical efficacy in the treatment group versus the control group: clinical verification shows that the traditional Chinese medicine composition has obvious curative effect on treating acne (see the table one).
Table one, comparison table of clinical efficacy of treatment group and control group
(P < 0.01, the difference is very significant)
2. Adverse reaction conditions
No significant adverse reaction was observed in both the treatment and control groups.
The clinical test results show that the traditional Chinese medicine composition has the cure rate of 73% for acne and the effective rate of 91.5%, has obvious effect compared with the control medicine, and has no obvious adverse reaction.
Detailed Description
Example 1 preparation of the Chinese medicinal composition Capsule of the invention
400G of mulberry leaf, 500g of caltrop, 200g of sea buckthorn and 50g of kuh-seng are respectively weighed and prepared into capsules according to the following method:
Pulverizing the obtained weight of radix Sophorae Flavescentis, sieving with 70 mesh sieve, soaking in 8 times of water for 4 hr, filtering, reflux extracting the residue with 75% ethanol at a ratio of 1:10 by mass to volume for 3 times, standing for 24 hr, filtering, and recovering ethanol to obtain filtrate; reflux extracting folium Mori juice after Sang Shezha juice with 8 times of water for 3 times, each time for 1.5 hr, filtering, and collecting filtrate; mixing the filtrates obtained in the above steps, adding the obtained mulberry leaf juice, mixing uniformly, concentrating, vacuum drying to obtain dry extract, adding the corresponding medicinal capsule auxiliary materials, mixing uniformly, and preparing 100 capsules.
Example 2 preparation of the Chinese medicinal composition oral liquid of the invention
500G of mulberry leaf, 400g of caltrop, 250g of sea buckthorn and 30g of kuh-seng are respectively weighed and prepared into capsules according to the following method:
Pulverizing the obtained weight of radix Sophorae Flavescentis, sieving with 60 mesh sieve, soaking in 10 times of water for 3 hr, filtering, reflux extracting the residue with 55% ethanol at a ratio of 1:5 for 2 times, standing for 24 hr, filtering, recovering ethanol from the filtrate, and collecting filtrate; reflux extracting folium Mori juice after Sang Shezha juice, folium Mori residue, fructus Tribuli and fructus Hippophae with 5 times of water for 3 times, each for 2 hr, filtering, and collecting filtrate; mixing the filtrates obtained in the above steps, adding the obtained mulberry leaf juice, mixing uniformly, concentrating, vacuum drying to obtain dry extract, adding the obtained extract into the corresponding oral liquid auxiliary material, mixing uniformly, adding water to 1000ml, and making into 100 pieces of oral liquid.
EXAMPLE 3 preparation of the gel of the Chinese medicinal composition of the invention
Respectively weighing 200g of mulberry leaves, 800g of caltrop, 300g of sea buckthorn and 10g of kuh-seng, and preparing the capsule according to the following method:
pulverizing the obtained weight of radix Sophorae Flavescentis, sieving with 80 mesh sieve, soaking in 5 times of water for 5 hr, filtering, reflux extracting the residue with 60% ethanol at a ratio of 1:8 for 4 times, standing for 24 hr each time, filtering, and recovering ethanol from the filtrate to obtain filtrate; reflux extracting folium Mori juice after Sang Shezha juice with 6 times of water for 3 times, each time for 1.5 hr, filtering, and collecting filtrate; mixing the filtrates, adding the obtained mulberry leaf juice, mixing, concentrating, adding proper medicinal adjuvants, and making into gel 100 tube.
EXAMPLE 4 preparation of the Chinese medicinal composition ointment of the invention
Respectively weighing 700g of mulberry leaves, 300g of caltrop, 100g of sea buckthorn and 150g of kuh-seng, and preparing the capsule according to the following method:
Pulverizing the obtained weight of radix Sophorae Flavescentis, sieving with 60 mesh sieve, soaking in 8 times of water for 4 hr, filtering, reflux extracting the residue with 70% ethanol at a ratio of 1:3 for 4 times, standing for 24 hr, filtering, recovering ethanol from the filtrate, and collecting filtrate; reflux extracting folium Mori juice after Sang Shezha juice, folium Mori residue, fructus Tribuli and fructus Hippophae with 5 times of water for 3 times, each for 2 hr, filtering, and collecting filtrate; mixing the filtrates, adding the mulberry leaf juice, mixing, concentrating, vacuum drying to obtain dry extract, adding appropriate medicinal adjuvants, mixing, and making into ointment 100 tubes.
Claims (13)
1. The traditional Chinese medicine composition for treating acne is characterized by being prepared from the following raw materials in parts by weight: 20-70 parts of mulberry leaf, 30-80 parts of caltrop, 10-30 parts of sea buckthorn and 1-15 parts of kuh-seng.
2. The traditional Chinese medicine composition according to claim 1, which is characterized by being prepared from the following raw materials in parts by weight: 35-50 parts of mulberry leaf, 40-60 parts of caltrop, 15-25 parts of sea buckthorn and 3-10 parts of kuh-seng.
3. The traditional Chinese medicine composition according to claim 1, which is characterized by being prepared from the following raw materials in parts by weight: 40 parts of mulberry leaf, 50 parts of caltrop, 20 parts of sea buckthorn and 5 parts of kuh-seng.
4. A method of preparing a Chinese medicinal composition according to any one of claims 1 to 3, wherein the Chinese medicinal composition is prepared by:
A. Weighing folium Mori, fructus Tribuli, fructus Hippophae and radix Sophorae Flavescentis according to the ratio;
B. pulverizing the taken lightyellow sophora root with a balance weight, adding 5-10 times of water for soaking, filtering, and respectively collecting filtrate and filter residues for later use;
C. adding ethanol into the lightyellow sophora root filter residues obtained in the step B, carrying out reflux extraction, standing for 24 hours, filtering, and recovering ethanol from the filtrate for later use;
D. reflux extracting folium Mori juice for later use after Sang Shezha juice, folium Mori residue, fructus Tribuli and fructus Hippophae with 3-12 times of water for 2-5 times, each time for 0.5-3 hr, filtering, and keeping filtrate for later use;
E. mixing the filtrate obtained in step B, C and step D with the mulberry leaf juice obtained in step D, concentrating, vacuum drying to obtain dry extract, adding corresponding medicinal adjuvants, and mixing to obtain other oral medicinal preparation or external preparation.
5. The method for preparing a Chinese medicinal composition according to claim 4, wherein the radix Sophorae Flavescentis in the step B is crushed into granules passing through a 60-80 mesh sieve, and soaked for 3-5 hours.
6. The method for preparing a Chinese medicinal composition according to claim 4, wherein the radix Sophorae Flavescentis in the step B is crushed into 70 mesh granules, and soaked for 4 hours.
7. The method for preparing a Chinese medicinal composition according to claim 4, wherein the concentration of ethanol in the step C is 50-75%, and the feed liquid ratio of the filter residue to the ethanol is 1: 3-10 times, 2-4 times of extraction, each time for 1-3 hours.
8. The method for preparing a Chinese medicinal composition according to claim 4, wherein the concentration of ethanol in the step C is 60-70%, and the feed liquid ratio of the filter residue to ethanol is 1: 5-8 times, extracting for 3 times each for 2 hours.
9. The method for preparing the Chinese medicinal composition according to claim 4, wherein in the step D, the mulberry leaf residue, the caltrop and the sea buckthorn are added with 5-8 times of water for reflux extraction for 3 times, and each time is extracted for 1-2 hours.
10. The method for preparing the Chinese medicinal composition according to claim 4, wherein in the step D, the mulberry leaf, the caltrop and the sea buckthorn are extracted by reflux with 6 times of water for 3 times, each time for 1.5 hours.
11. The traditional Chinese medicine composition according to claim 1, characterized in that the traditional Chinese medicine composition is an oral preparation.
12. The traditional Chinese medicine composition according to claim 1, characterized in that the traditional Chinese medicine composition is an external preparation.
13. The use of the Chinese medicinal composition according to claim 1 in the preparation of a medicament for treating acne.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1895593A (en) * | 2006-06-23 | 2007-01-17 | 段阳泉 | Medicine for treating acne and its preparation |
| CN102370759A (en) * | 2011-11-17 | 2012-03-14 | 中国中医科学院中医临床基础医学研究所 | Compound Chinese medicinal preparation for treating acne and preparation method thereof |
| CN103169915A (en) * | 2011-12-22 | 2013-06-26 | 湖南九典制药有限公司 | Application of preparation of traditional Chinese medicine composition for treating acne |
| CN103169800A (en) * | 2011-12-22 | 2013-06-26 | 湖南九典制药有限公司 | Traditional Chinese medicine composition for treating acne and preparation method and application thereof |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1895593A (en) * | 2006-06-23 | 2007-01-17 | 段阳泉 | Medicine for treating acne and its preparation |
| CN102370759A (en) * | 2011-11-17 | 2012-03-14 | 中国中医科学院中医临床基础医学研究所 | Compound Chinese medicinal preparation for treating acne and preparation method thereof |
| CN103169915A (en) * | 2011-12-22 | 2013-06-26 | 湖南九典制药有限公司 | Application of preparation of traditional Chinese medicine composition for treating acne |
| CN103169800A (en) * | 2011-12-22 | 2013-06-26 | 湖南九典制药有限公司 | Traditional Chinese medicine composition for treating acne and preparation method and application thereof |
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