CN110538308A

CN110538308A - Traditional Chinese medicine composition for hair growth and preparation method thereof

Info

Publication number: CN110538308A
Application number: CN201910890356.XA
Authority: CN
Inventors: 曹花荣
Original assignee: Jiujiang Baihutang Rongfabao Biotechnology Co Ltd
Current assignee: Jiujiang Baihutang Rongfabao Biotechnology Co Ltd
Priority date: 2019-09-20
Filing date: 2019-09-20
Publication date: 2019-12-06
Anticipated expiration: 2039-09-20
Also published as: CN110538308B

Abstract

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition capable of growing hair, and a preparation method and application thereof. The invention combines the modern traditional Chinese medicine pharmacological research, mainly benefits qi, activates blood and dredges channels, and provides a novel external traditional Chinese medicine composition for promoting hair growth, which comprises the following raw material medicines: the traditional Chinese medicine composition is prepared from ginger, polygonum multiflorum, rhizoma drynariae, eclipta, mulberry, schisandra chinensis, glossy privet fruit, angelica sinensis, black sesame, gastrodia elata, safflower, ginseng and dried orange peel, industrial products are not used in the preparation of the traditional Chinese medicine composition, and the traditional Chinese medicine composition is safe, non-toxic and suitable for household use.

Description

Traditional Chinese medicine composition for hair growth and preparation method thereof

Technical Field

the invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition capable of growing hair, and a preparation method and application thereof.

background

In modern society, along with the change of life style and the acceleration of life rhythm, competition is increasingly violent, meanwhile, environmental pollution and unhealthy dietary structure are caused, the number of alopecia people is gradually increased, the alopecia is generated from old people to young people, the alopecia is younger and the alopecia stopping and growing become important points of modern society attention

At present, hair growth products in the society are numerous and uneven, are regulated by western medicines, have quick response, but have larger toxic and side effects, higher price and higher recurrence rate after stopping taking the medicines; there are oral traditional Chinese medicine decoction, oral liquid, etc., but oral decoction is often inconvenient, it is difficult to insist on taking for a long time, modern preparation exist add numerous supplementary product, may aggravate the injury of liver and kidney; the external shampoo product has poor effect, complex components and chemical products, and damages the hair and the scalp.

Because the reasons of alopecia are complex, no specific medicine is available in treatment, and the treatment of alopecia is still a difficult problem in the medical field. Therefore, the development of a safer and more effective hair growth promoting product is urgently needed.

Disclosure of Invention

The invention aims to provide a safe and effective hair-growing external traditional Chinese medicine composition, a preparation method and application, which aim at the defects in the prior art, utilize the traditional Chinese medicine theory, carry out dialectical compatibility and prescription aiming at various alopecia diseases and treat both symptoms and root causes.

The invention aims to provide a novel external traditional Chinese medicine composition for promoting hair growth, which comprises the following raw material medicines: ginger, polygonum multiflorum, rhizoma drynariae, eclipta, mulberry, schisandra chinensis, glossy privet fruit, angelica, black sesame, gastrodia elata, safflower, ginseng and dried orange peel.

the traditional Chinese medicine composition comprises the following raw material medicines in parts by weight: 10-30 parts of ginger, 10-30 parts of polygonum multiflorum, 1-10 parts of rhizoma drynariae, 1-10 parts of eclipta, 1-10 parts of mulberry, 1-10 parts of schisandra chinensis, 1-10 parts of glossy privet fruit, 1-10 parts of angelica sinensis, 1-10 parts of black sesame, 1-8 parts of gastrodia elata, 1-8 parts of safflower, 1-8 parts of ginseng and 1-6 parts of dried orange peel.

Preferably, the traditional Chinese medicine composition comprises the following raw material medicines in parts by weight: 15-25 parts of ginger, 15-25 parts of polygonum multiflorum, 2-8 parts of drynaria rhizome, 2-8 parts of eclipta, 2-8 parts of mulberry fruit, 2-8 parts of schisandra chinensis, 2-8 parts of glossy privet fruit, 2-8 parts of angelica sinensis, 1-5 parts of black sesame, 1-5 parts of gastrodia elata, 1-5 parts of safflower, 1-5 parts of ginseng and 1-3 parts of dried orange peel.

In a specific embodiment, the traditional Chinese medicine composition comprises the following raw material medicines in parts by weight: 18 parts of ginger, 16 parts of fleece-flower root, 5 parts of rhizoma drynariae, 5 parts of yerbadetajo herb, 5 parts of mulberry fruit, 5 parts of Chinese magnoliavine fruit, 5 parts of glossy privet fruit, 5 parts of Chinese angelica, 2 parts of black sesame, 2 parts of gastrodia elata, 2 parts of safflower, 2 parts of ginseng and 1 part of dried orange peel.

in a specific embodiment, the traditional Chinese medicine composition comprises the following raw material medicines in parts by weight: 20 parts of ginger, 20 parts of polygonum multiflorum, 6 parts of rhizoma drynariae, 6 parts of yerbadetajo herb, 6 parts of mulberry fruit, 6 parts of schisandra chinensis, 6 parts of glossy privet fruit, 6 parts of angelica, 2 parts of black sesame, 2 parts of gastrodia elata, 2 parts of safflower, 2 parts of ginseng and 1 part of dried orange peel.

In a specific embodiment, the traditional Chinese medicine composition comprises the following raw material medicines in parts by weight: 24 parts of ginger, 18 parts of polygonum multiflorum, 6 parts of rhizoma drynariae, 6 parts of eclipta, 6 parts of mulberry, 5 parts of schisandra chinensis, 5 parts of glossy privet fruit, 5 parts of angelica, 3 parts of black sesame, 2 parts of gastrodia elata, 2 parts of safflower, 2 parts of ginseng and 1 part of dried orange peel.

In a specific embodiment, the ginger in the Chinese medicinal composition of the present invention is dried ginger.

In a specific embodiment, the polygonum multiflorum is prepared polygonum multiflorum in the traditional Chinese medicine composition of the invention.

In a specific embodiment, the rhizoma drynariae in the traditional Chinese medicine composition of the invention is scalded rhizoma drynariae.

In a specific embodiment, the mulberry in the traditional Chinese medicine composition of the invention is dried mulberry.

In a specific embodiment, the fructus ligustri lucidi in the traditional Chinese medicine composition of the present invention is wine fructus ligustri lucidi or steamed fructus ligustri lucidi.

In a specific embodiment, the angelica in the Chinese medicinal composition of the invention is wine-processed angelica.

In a specific embodiment, the safflower in the traditional Chinese medicine composition of the invention is a processed product thereof, such as fried safflower, safflower charcoal and vinegar safflower.

The invention treats based on syndrome differentiation, treats various alopecia diseases by tonifying qi and activating blood circulation and dredging channels, can promote metabolism function and hair root nutrient absorption, and can promote blood circulation to remove blood stasis and stimulate hair follicle growth. In the invention, the polygonum multiflorum is used for enriching blood and growing hair, and the rhizoma drynariae is used for activating blood and growing hair, and is used as monarch drug together; ginger has the effects of relieving exterior syndrome, dispelling cold and controlling oil, black sesame has the effects of tonifying qi and liver and kidney, tall gastrodia tuber has the effects of calming endogenous wind, relieving spasm, expanding capillary vessels and hair follicles, ginseng has the effect of tonifying primordial qi, Chinese magnoliavine fruit has the effects of tonifying qi and promoting the production of body fluid, and glossy privet fruit has the effect of nourishing liver and kidney and is used; the yerbadetajo herb, the safflower, the angelica and the mulberry fruit are used as adjuvant drugs for assisting in enriching the blood; chen Pi guides qi and guides the herbs downward, which is used as guiding drug. The medicines are combined to play the roles of tonifying qi, activating blood circulation and dredging channels and vessels, and have the effect of growing hair.

(1) Ginger (fresh ginger)

Fresh rhizomes of Zingiber officinale Rosc. Pungent and warm. It enters lung, spleen and stomach meridians. Relieve exterior syndrome, dispel cold, warm middle energizer, arrest vomiting, resolve phlegm and stop cough. Can be used for treating common cold due to wind-cold, emesis due to stomach cold, and cough due to cold phlegm.

the ginger contains 0.25 to 3.0 percent of volatile oil, and the main components of the ginger comprise gingerol, shogaol, phellandrene, camphene, citral, linalool, methyl heptenone, nonanal, d-borneol and the like. Contains pungent component gingerol, and is decomposed into oily pungent component zingiberenone and crystalline pungent component zingerone and gingerpinone mixture. Also contains asparagines, pipecolic acid-2, glutamic acid, aspartic acid, serine, glycine, etc. In addition, it contains a resinous material and starch.

The pharmacological action is as follows: rhizoma Zingiberis recens can be used in digestive system, circulation system and respiratory system, and has effects of promoting secretion of gastric juice and free hydrochloric acid, stopping vomit, regulating intestinal tension, regulating central nervous system and respiratory system, and resisting bacteria and protozoan.

(2) Polygonum multiflorum Thunb

Root tuber of Polygonum multiflorum Thunb of Polygonaceae. Bitter, sweet, astringent and slightly warm. It enters liver, heart and kidney meridians. Detoxify, cure abscess, check malaria, moisten intestines to relieve constipation. It can be used for treating skin ulcer, carbuncle, scrofula, rubella, pruritus, deficiency-type chronic malaria, constipation due to intestinal dryness. The prepared fleece-flower root, radix polygoni multiflori preparata product can tonify liver and kidney, replenish essence and blood, blacken beard and hair and strengthen tendons and bones. Can be used for treating blood deficiency, sallow complexion, giddiness, tinnitus, early white beard and hair, soreness of waist and knees, numbness of limbs, metrorrhagia, leukorrhagia, and asthenia due to chronic malaria.

Mainly contains anthraquinone compounds, wherein the main components comprise chrysophanol, emodin, physcion, rhein, aloe-emodin, lecithin, crude fat and the like.

the pharmacological action is as follows: anthraquinone in Polygoni Multiflori radix has effects of reducing blood lipid, resisting atherosclerosis, resisting bacteria, loosening bowel to relieve constipation, resisting tumor, improving immunity, resisting aging and promoting learning and memory ability. Radix Polygoni Multiflori Preparata can increase blood erythrocyte count and hemoglobin content.

(3) Rhizoma drynariae

Dried rhizome of Drynaria fortunei (Kunze) J.Sm. Bitter and warm. It enters kidney and liver meridians. Tonify kidney, strengthen bone, heal wound and alleviate pain. Can be used for treating lumbago due to kidney deficiency, tinnitus, deafness, odontoseisis, traumatic injury, contusion, and fracture of bones and muscles; it is used externally to treat alopecia areata and vitiligo.

The rhizome of drynaria fortunei contains starch 16.4%, glucose 5.37%, and naringin.

The pharmacological action is as follows: the Drynariae rhizoma is used for promoting healing of experimental rat bone injury, stimulating compensatory proliferation of osteochondral cells of rat experimental arthritis, increasing beating frequency of myocardial cells of rat suckling mice cultured in vitro, and preventing streptomycin toxicity and anaphylaxis and treating clavus.

(4) Herba Ecliptae

Dried aerial parts of Eclipta prostrata L. of Eclipta prostrata of Compositae. Sweet, sour and cold. It enters kidney and liver meridians. Nourishing liver and kidney, cooling blood and stopping bleeding. Can be used for treating odontoseisis, premature gray hair, giddiness, tinnitus, soreness of waist and knees, yin deficiency, blood heat, hematemesis, epistaxis, hematuria, dysentery with bloody stool, metrorrhagia, metrostaxis, and traumatic hemorrhage.

The eclipta contains various active ingredients, and reported separated chemical ingredients mainly comprise triterpenoid saponin, flavonoid compounds, various thiophene compounds, vanillyl ether compounds, steroids and the like.

the pharmacological action is as follows: has hemostatic, tranquilizing and analgesic effects on central nervous system, and can be used for treating dysentery and diphtheria.

(5) Mulberry fruit

Fruit cluster of Morus alba L. Sweet, sour and cold in nature. It enters liver and kidney meridians. Nourishing yin and blood, promoting fluid production, moisturizing intestine, treating dizziness, soreness of waist, tinnitus, premature gray hair, insomnia, dreaminess, thirst, diabetes, and constipation due to intestinal dryness caused by deficiency of liver and kidney and blood deficiency.

The mulberry fruit contains sugar, mixed acid, malic acid, vitamins B1, B2, C and carotene. The fatty acids of mulberry oil are mainly composed of linoleic acid and amounts of stearic acid, oleic acid, etc.

The pharmacological action is as follows: the mulberry decoction has the function of moderately stimulating lymphocyte transformation.

(6) schisandra chinensis

Dried ripe fruit of Schisandra chinensis (Turcz.) Baill, Magnoliaceae. Sour, sweet and warm. It enters lung, heart and kidney meridians. Astringe to arrest discharge, benefit qi and promote the production of body fluid, tonify kidney and calm heart. Can be used for treating chronic cough, asthma, nocturnal emission, enuresis, frequent micturition, chronic diarrhea, spontaneous perspiration, night sweat, thirst due to body fluid consumption, short breath, weak pulse, internal heat, diabetes, palpitation, and insomnia. Schisandra chinensis contains schizandrin, deoxyschizandrin, kadsurin, schizandrin, schisantherin, A, B, C, D, E, F, G, H, J, K1, K2, K3, L1, L2, M1, M2, N2, O, R and the like.

The pharmacological action is as follows: has exciting effect on nervous system central nervous system, and has influence on exciting and inhibiting processes of cerebral cortex, so as to balance. Has effects of exciting respiratory system, relieving cough and eliminating phlegm. Can reduce blood pressure. Has effects in promoting bile flow, reducing serum transaminase, and protecting liver cells. Has adaptogen effect similar to that of ginseng, and can enhance the defense capacity of organism to nonspecific stimulation. Can increase cellular immunity, and significantly enhance SOD activity of brain, liver and spleen, so as to improve immunity, resist oxidation and resist aging. Has inhibitory effect on Staphylococcus aureus, pneumonia bacillus, intestinal Salmonella, and Pseudomonas aeruginosa.

(7) Glossy privet fruit

Dried ripe fruit of Ligustrum lucidum ait. Sweet, bitter and cool. It enters liver and kidney meridians. Nourishing liver and kidney, improving eyesight and blackening hair. Can be used for treating vertigo, tinnitus, soreness of waist and knees, premature gray hair, and dim eyesight.

Fructus Ligustri Lucidi contains fructus Ligustri Lucidi glycoside (nuzhenide), Oleuropein (oleuropein), oleanolic acid (oleanic acid), 4-hydroxy-B-phenethyl-B-D-glucoside, betulin, etc.

The pharmacological action is as follows: has effects in reducing blood lipid, resisting arteriosclerosis, lowering blood sugar, resisting liver injury, improving immunity, inhibiting phagocytic activity of reticuloendothelial system, resisting inflammation, cancer and mutation, regulating endocrine system, improving hemopoietic ability, tonifying heart, dilating coronary blood vessel, and dilating peripheral blood vessel; diuresis, cough relieving, laxative, antibacterial, etc.

(8) Radix Angelicae sinensis

Dried roots of Angelica sinensis (Oliv.) Diels of Umbelliferae. Sweet, pungent and warm. It enters liver, heart and spleen meridians. Tonify blood, activate blood, regulate menstruation, alleviate pain, moisten intestines to relieve constipation. Can be used for treating blood deficiency, sallow complexion, giddiness, palpitation, menoxenia, amenorrhea, dysmenorrhea, asthenia cold, abdominal pain, constipation due to intestinal dryness, rheumatic arthralgia, traumatic injury, superficial infection, pyocutaneous disease. The wine angelica sinensis can activate blood and promote menstruation. Can be used for treating amenorrhea, dysmenorrhea, rheumatalgia, and traumatic injury.

The root contains volatile oil. The essential components of the volatile oil are as follows: butylene phthalide, o-carboxyphenyln-pentanone and delta 2, 4-dihydrophthalic anhydride. The essential oil is complex in composition and contains more than 10 kinds of low boiling point components alone, and there are many kinds of hydrocarbons, including 3 kinds of terpenes.

The pharmacological action is as follows: can be used for treating muscle and joint pain, neuralgia, chronic tracheitis, menopathy, hypertension, herpes zoster, and rhinitis.

(9) black sesame

black seeds of sesame of the family Pedaliaceae. Sweet and neutral. It enters liver, spleen and kidney meridians. Tonifying the liver and kidney; nourishing blood and replenishing vital essence; to moisten intestines and relax bowels. Mainly treats dizziness and tinnitus, flaccidity of waist and feet, premature beard and hair and dry skin caused by deficiency of liver and kidney; constipation due to intestinal dryness; women have less human milk; carbuncle, sore and eczema; treating rheumatic arthritis; scrofula of children; injury due to fire and soup; hemorrhoids are treated.

The semen Sesami Niger seed contains fatty oil, which contains glyceride of oleic acid, linoleic acid, palmitic acid, stearic acid, arachidic acid, and tetracosanoic acid, sesamin, sesamolin, sesamol, vitamin E, phytosterol, and lecithin. Contains sesamin, protein, oligosaccharide, plantago sugar, and sesame sugar. And small amount of phosphorus, potassium, cytochrome, folic acid, nicotinic acid, sucrose, pentosan, and calcium.

The pharmacological action is as follows: the black sesame has the functions of reducing blood sugar, promoting adrenal gland, resisting inflammation and inducing diarrhea, and the linoleic acid in the black sesame can reduce the content of cholesterol in blood and has the function of preventing and treating coronary arteriosclerosis.

(10) Gastrodia tuber

Dried tubers of Gastrodia elata Blume, Orchidaceae. Sweet and neutral. It enters liver meridian. For stopping endogenous wind and spasm, calming liver yang, dispelling pathogenic wind and dredging collaterals, and can be used for treating infantile convulsion, epilepsy, tetanus, headache, giddiness, extremity paralysis, limbs anesthesia, and rheumatalgia.

wherein the medicinal component is gastrodine, also called gastrodine, whose chemical composition is p-hydroxymethyl benzene-beta-D-glucopyranoside; in addition, the gastrodia elata ether glycoside has the chemical composition of bis- (4-hydroxybenzyl) -ether-mono-beta-D-glucopyranoside.

The pharmacological action is as follows: has effects in tranquilizing mind, relieving convulsion, protecting brain nerve cells, preventing vertigo, lowering blood pressure, resisting platelet aggregation, resisting thrombosis, relieving inflammation, relieving pain, resisting myocardial ischemia, protecting cardiac muscle cells, improving memory, delaying aging, and enhancing immunity.

(11) Safflower carthamus

Dried flower of Carthamus tinctorius L. of Compositae. Pungent and warm in nature. It enters heart and liver meridians. Promoting blood circulation, dredging channels, removing blood stasis and relieving pain. Can be used for treating amenorrhea, dysmenorrhea, lochiorrhea, abdominal mass, thoracic obstruction, cardialgia, abdominal pain due to blood stasis, thoracic and hypochondriac pain, traumatic injury, and pain and swelling of skin and external diseases.

Safflower mainly contains carthamin, neocarthamin, safflower quinoside, carthamin, safflower yellow, nonacosane, beta-sitosterol, palmitic acid, myristic acid, lauric acid, dipalmitic acid, glyceride, oleic acid and linoleic acid, the main component of the volatile oil in the flower is a mixture of polyacetylenes, and 85 other components are also identified. In addition, safflower also contains xylan, fatty oil, safflower polysaccharide and 16 amino acids, wherein the content of lysine is 0.8%.

The pharmacological action is as follows: carthami flos has effects of dilating blood vessel, increasing blood flow, improving microcirculation and inhibiting platelet aggregation, and can be used for treating thrombotic cerebrovascular diseases and protecting brain tissue of cerebral infarction animals.

(12) ginseng radix

Dried root of Panax ginseng C.A.Mey. belonging to Araliaceae family. Sweet, slightly bitter and warm. It enters spleen, lung, heart and kidney meridians. Tonify primordial qi, recover pulse to stop collapse, tonify spleen and lung, promote the production of body fluid and nourish blood, induce tranquilization and promote intelligence. Can be used for treating asthenia, collapse, cold limbs, weak pulse, spleen deficiency, anorexia, lung deficiency, cough, asthma, body fluid deficiency, thirst, internal heat, diabetes, deficiency of both qi and blood, asthenia, palpitation, insomnia, sexual impotence, and cold womb.

The root contains ginsenoside 0.4% and small amount of volatile oil. The main component of the oil is 0.072 percent of ginseng alkene. Saponin and panaxynol can also be added. In addition, it also contains monosaccharide, ginseng acid, multivitamin, various amino acids, choline, enzyme and spermine.

The pharmacological action is as follows: ginseng radix has exciting effect on central nervous system, but has inhibiting effect when large amount is used; has direct effect on cardiac muscle and blood vessel; strengthening the resistance of the body to harmful factors; the composition has the effect of reducing blood sugar of animals with hyperglycemia caused by epinephrine; can promote the gonad function of animals; improve anemia and the like.

(13) Dried orange peel

Dried mature pericarp of Citrus reticulata Blanco of the Rutaceae family and its cultivars. Bitter, pungent and warm. It enters lung and spleen meridians. Regulate qi to invigorate spleen, dry dampness and resolve phlegm. Can be used for treating fullness in chest and abdomen, anorexia, vomiting, diarrhea, cough, and excessive phlegm.

Pericarpium Citri Tangerinae contains volatile oil 1.5% (squeezing method) to 2% (distillation method), the oil contains D-limonene, beta-myrcene alpha-and beta-pinene, and other main components, and contains flavonoid such as hesperidin, neohesperidin, naringenin, dihydronobiletin and 5-nordihydronobiletin; it is also reported that Chuan Chenpi contains about 8.4% of hesperidin and about 0.15% of nobiletin, and additionally contains 0.28% -2.54% of synephrine (parahydroxyfolin).

the pharmacological action is as follows: the volatile oil contained in the dried orange peel has mild stimulation effect on gastrointestinal tracts, can promote the secretion of digestive juice and eliminate pneumatosis in intestinal tracts; the tangerine peel decoction, the alcohol extract and the like can excite cardiac muscle, but the suppression is generated when the dosage is too large, the slight contraction of blood vessels can be generated, the blood pressure can be rapidly increased, and the pectin in the tangerine peel also has a certain prevention effect on arteriosclerosis caused by high fat diet; the volatile oil contained in the dried orange peel has the effects of stimulating and passively eliminating phlegm, so that the phlegm is easy to be expectorated; can contract renal blood vessel and reduce urine volume; the decoction of pericarpium Citri Tangerinae can be used together with vitamin C and vitamin K to enhance antiinflammatory effect.

In a specific embodiment, the traditional Chinese medicine composition further comprises a pharmaceutically acceptable adjuvant.

The traditional Chinese medicine composition can be prepared into various external preparations, such as liniment, nano-emulsion, gel, transdermal patch, powder, lotion, aerosol, spray, microemulsion gel, patch, liposome gel and foam.

In a specific embodiment, the Chinese medicinal composition of the present invention further comprises a cosmetic base.

The traditional Chinese medicine composition can be prepared into various cosmetics, such as hair conditioner, hair spray, shampoo, essence and hair tonic.

Another object of the present invention is a method for preparing the Chinese medicinal composition of the present invention.

The traditional Chinese medicine composition can be prepared by the following steps: drying the above materials, grinding into powder, and mixing to obtain effective components.

The traditional Chinese medicine composition can also be prepared by the following steps:

the method comprises the following steps: extracting the raw materials with water to obtain effective components of the Chinese medicinal composition;

The second method comprises the following steps: extracting the raw materials with water, and fermenting to obtain the effective components of the Chinese medicinal composition.

In the preparation steps of the effective components contained in the traditional Chinese medicine composition,

The water extraction conditions are as follows: adding water 6-12 times of the total weight of the raw materials, decocting for 1-3 hr, and soaking for 24-72 hr;

The water extraction and fermentation conditions are as follows: adding water 6-12 times of the total weight of the raw materials, decocting for 1-3 hr, and soaking for 24-72 hr to obtain decoction; cooling the decoction to 30-50 deg.C, adding yeast and acetic acid, and sealing for 1-2 months.

In the prior art, the external hair-growing traditional Chinese medicine composition is mostly soaked in industrial ethanol or white spirit for alcohol extraction, so that the dissolution of active ingredients of traditional Chinese medicine raw material medicines is promoted, and the extraction rate is improved. The preparation method does not use industrial ethanol extraction or white spirit soaking, and if the method II uses a water extraction fermentation technology, the preparation method reduces the industrial cost, is safe and nontoxic, and can be used for families.

In a specific embodiment, in the preparation method of the traditional Chinese medicine composition, one or more of salt, acetin and edible essence can be added, and preferably, the acetin is brewed by 1% edible rice.

In a specific embodiment, the preparation method of the traditional Chinese medicine composition comprises the following steps: the preparation method comprises the following steps of baking raw material medicines in parts by weight, placing the baked raw material medicines into an extraction tank, adding water which is 10 times of the total weight of the raw material medicines, decocting for 1 hour, and soaking for 24 hours to obtain effective components.

In a specific embodiment, the preparation method of the traditional Chinese medicine composition comprises the following steps: baking raw material medicines in parts by weight, putting the baked raw material medicines into an extraction tank, adding water which is 8-10 times of the total weight of the raw material medicines, decocting for 1-2 hours, and soaking for 24 hours to obtain a decoction; cooling the decoction to 30-50 deg.C, adding yeast and acetic acid, sealing the tank for 1-2 months to obtain fermentation liquid, and filtering to obtain effective components.

In a specific embodiment, the preparation method of the traditional Chinese medicine composition comprises the following steps: the fermentation liquor can also be added with trace salt and 1% edible rice to brew vinegar essence and edible essence.

The obtained effective components can be directly used as medicine or added with pharmaceutically acceptable adjuvants or cosmetic matrix to make into desired preparation or cosmetic.

The effective components of the traditional Chinese medicine composition can be prepared into various external preparations by screening auxiliary materials, such as liniment, gel, transdermal patches, powder, lotion, aerosol, spray and the like, and can also be prepared into novel hair-growing external preparations such as nano-emulsion machines, micro-emulsion gels, patches, liposome gels, foam preparations and the like, and excellent effects such as good transdermal effect, long action time and the like can be achieved.

The active ingredients of the traditional Chinese medicine composition can also be prepared into various cosmetics, such as hair conditioner, hair spray, shampoo, essence and hair tonic.

In a specific embodiment, the hair tonic prepared from the effective components of the Chinese medicinal composition of the present invention can be prepared by: bottling the effective components to obtain hair growth promoting liquid.

In a specific embodiment, the essence made of the effective components of the traditional Chinese medicine composition can be prepared by the following steps: adding glycerol, dipeptide diaminobutyrylbenzyl amide diacetate, grape seed oil, antioxidant and water in balance into the effective components, mixing, heating to 60-80 ℃, and uniformly stirring to obtain the essence.

In a specific embodiment, the gel prepared from the effective components of the Chinese medicinal composition can be prepared by the following steps: adding carbomer into appropriate amount, swelling completely, and adjusting pH to 5-7 with sodium hydroxide; mixing the effective components with propylene glycol and appropriate amount of water, stirring, adding appropriate amount of azone, and stirring to obtain gel.

In a specific embodiment, the microemulsion gel prepared from the effective components of the Chinese medicinal composition can be prepared by the following steps: mixing ethanol, linoleic acid glyceride and microemulsion concentrate, adding effective components, and dissolving completely to obtain transparent microemulsion; weighing gel matrix, adding into water, stirring, standing, swelling, mixing, slowly adding microemulsion, adding azone, stirring, and adjusting pH to 6-8 to obtain microemulsion gel.

in a specific embodiment, the patch made of the effective components of the Chinese medicinal composition of the present invention can be prepared by: heating and concentrating the effective components, adding silicone pressure sensitive adhesive, mixing, coating on anti-sticking material, drying at 65-85 deg.C, compounding with backing material, and punching to obtain patch.

In a specific embodiment, the nanoemulsion prepared from the effective components of the Chinese medicinal composition can be prepared by the following steps: mixing the effective components, soybean phospholipid, oleic acid and refined soybean oil, heating to 65-80 deg.C to clarify to obtain oil solution, dispersing poloxamer and propylene glycol into water for injection, stirring while adding the oil solution of the effective components to obtain oil-water phase dispersion system, making into crude emulsion, adding water, emulsifying the crude emulsion under 100-150Mpa by emulsifying machine, sterilizing at 110-120 deg.C, and packaging to obtain nanometer emulsion.

The above preparation method is only illustrative of the preparation method of the present invention, but it should not be understood that the preparation method of the present invention is limited to the above-listed method.

The third purpose of the invention is to provide the application of the traditional Chinese medicine composition in preparing a hair growth medicine.

In the present invention, unless otherwise specified, wherein:

the term "water extraction" refers to the process of decoction of the raw materials followed by extraction of the juice.

The term "water extraction and fermentation" refers to the process that after a decoction (containing dregs) of a raw material medicine is subjected to water extraction, the solubility of certain medicine components in the decoction is increased after the fermentation of yeast and acetic acid, so that the content of an extract in the decoction is increased.

The term "active ingredient" refers to a solution of the extract of a drug substance that has been extracted or fermented to provide a therapeutic effect.

Compared with the prior art, the invention has the following beneficial effects:

1. The traditional Chinese medicine composition disclosed by the invention is combined with the pharmacological research of modern traditional Chinese medicines, mainly benefits qi and activates blood and dredges channels, adopts the traditional Chinese medicine composition to grow hair, treats both principal and secondary aspects of diseases, and is flexible in prescription application and low in cost.

2. The preparation of the traditional Chinese medicine composition does not use industrial products, is safe and nontoxic, and can be suitable for families.

3. The traditional Chinese medicine composition is prepared into an external preparation or a cosmetic, and has the advantages of obvious curative effect, no relapse, convenient use and small irritation.

Drawings

FIG. 1 is a graph showing the effect of the Chinese medicinal composition of the present invention on case 1 before and after use in individual test examples; among them, 1.1 shows the hair growth state of the top of the head before use, and 1.2 shows the hair growth state of the top of the head after three months of use.

FIG. 2 is a graph showing the effect of the Chinese medicinal composition of the present invention on case 2 before and after use in individual test examples: among them, 2.1 shows the hair growth condition on the front of the top of the head before use, and 2.2 shows the hair growth condition on the front of the top of the head after one month of use.

FIG. 3 is a graph showing the effect of the Chinese medicinal composition of the present invention on case 3 before and after use in individual test cases: among them, 3.1 shows the hair growth condition on the front of the top of the head before use, and 3.2 shows the hair growth condition on the front of the top of the head after six months of use.

Detailed Description

Embodiments of the present invention will be described in detail below with reference to examples, but those skilled in the art will appreciate that the following examples are only illustrative of the present invention and should not be construed as limiting the scope of the present invention. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products commercially available.

Examples 1-8 preparation of the Chinese medicinal composition of the present invention

Example 1

Taking 10g of dried ginger, 10g of polygonum multiflorum, 1g of rhizoma drynariae, 1g of eclipta, 1g of mulberry, 1g of schisandra chinensis, 1g of glossy privet fruit, 1g of angelica, 1g of black sesame, 1g of gastrodia elata, 1g of safflower, 1g of ginseng and 1g of dried orange peel, baking, putting the baked ginger, the glossy privet fruit, the angelica, the black sesame, the gastrodia elata, the safflower, the ginseng and the dried orange peel into an extraction tank, adding 310ml of water, decocting; cooling the decoction to 40 deg.C, adding yeast and acetic acid, sealing the jar for 2 months to obtain 155ml fermentation liquid; adding trace amount of salt and 1% edible rice into the fermentation liquid, brewing vinegar essence and edible essence, filtering to obtain 140ml effective components, and bottling to obtain hair growth promoting liquid.

Example 2

Taking 15g of dried ginger, 15g of polygonum multiflorum, 2g of rhizoma drynariae, 2g of eclipta, 2g of mulberry, 2g of schisandra chinensis, 2g of wine-processed glossy privet fruit, 2g of angelica, 2g of black sesame, 2g of gastrodia elata, 2g of safflower, 2g of ginseng and 2g of dried orange peel, baking, putting the baked ginger, the wine-processed glossy privet fruit into an extraction tank, adding 380ml of water, decocting for 2 hours, and soaking for 48 hours to obtain 225ml of decoction; cooling the decoction to 40 deg.C, adding yeast and acetic acid, sealing the tank for 1 month to obtain 220ml fermentation liquid; adding 1% edible rice into the fermentation liquor to brew acetin, and filtering to obtain 198ml of effective components; adding 12g of yolk phospholipid and 4g of oleic acid into 100g of refined soybean oil, heating to 85 ℃, and mixing until the mixture is clear to obtain 300ml of oil solution; dispersing poloxamer 12g and propylene glycol 22g into water for injection to obtain water phase, dripping oil solution under stirring to obtain oil-water phase dispersion system, making into coarse emulsion, and adding water to 1000 ml; further emulsifying the obtained coarse emulsion with homogenizing machine under 100Mpa, sterilizing at 110 deg.C for 20min, and packaging to obtain nanometer emulsion.

Example 3

Taking 18g of dried ginger, 16g of prepared fleece-flower root, 5g of rhizoma drynariae, 5g of eclipta, 5g of mulberry, 5g of schisandra chinensis, 5g of steamed glossy privet fruit, 5g of angelica, 2g of black sesame, 2g of gastrodia elata, 2g of safflower, 2g of ginseng and 1g of dried orange peel, baking, putting the baked dried ginger into an extraction tank, adding 700ml of water, decocting for 2 hours, and soaking for 24 hours to obtain 430ml of decoction; cooling the decoction to 50 deg.C, adding yeast and acetic acid, sealing the tank for 2 months to obtain 425ml fermentation liquid; adding trace salt and 1% edible rice into the fermentation liquid to brew acetin, filtering to obtain 395ml effective component, heating the effective component to 100 deg.C, concentrating for 1 hr, adding 200g silicone pressure sensitive adhesive, mixing, coating on anti-sticking material, drying at 65-85 deg.C, compounding with backing material, and die-cutting to obtain patch.

Example 4

Taking 20g of dried ginger, 20g of polygonum multiflorum, 6g of rhizoma drynariae, 6g of eclipta, 6g of mulberry, 6g of schisandra chinensis, 6g of glossy privet fruit, 6g of angelica, 2g of black sesame, 2g of gastrodia elata, 2g of safflower, 2g of ginseng and 1g of dried orange peel, baking, putting the mixture into an extraction tank, adding 850ml of water, decocting for 2 hours, and soaking for 24 hours to obtain 485ml of decoction; cooling the decoction to 50 deg.C, adding yeast and acetic acid, sealing the jar for 2 months to obtain 480ml fermentation liquid; adding trace amount of salt and 1% edible rice into the fermentation liquid, brewing vinegar essence and edible essence, filtering to obtain 460ml effective components, and bottling to obtain hair growth promoting liquid.

Example 5

taking 20g of dried ginger, 15g of polygonum multiflorum, 5g of scalded rhizoma drynariae, 5g of eclipta, 5g of mulberry, 5g of schisandra chinensis, 5g of glossy privet fruit, 5g of angelica, 2g of black sesame, 1g of gastrodia elata, 1g of safflower, 1g of ginseng and 1g of dried orange peel, baking, putting the mixture into an extraction tank, adding 640ml of water, decocting for 1 hour, and soaking for 72 hours to obtain 485ml of decoction; cooling the decoction to 30 deg.C, adding yeast and acetic acid, sealing the jar for 1 month to obtain 480ml fermentation liquid; adding trace amount of salt and 1% edible rice brewed acetin and edible essence into the fermentation liquor, filtering to obtain 465ml of effective components, adding 23g of glycerol, 70g of dipeptide diaminobutyrylbenzyl amide diacetate, 37g of grape seed oil and 3g of antioxidant into the effective components, supplementing the balance to 500ml, mixing, heating to 60 ℃, and uniformly stirring to obtain the essence.

Example 6

Taking 24g of dried ginger, 18g of prepared fleece-flower root, 6g of rhizoma drynariae, 6g of eclipta, 6g of mulberry fruit, 5g of Chinese magnoliavine fruit, 5g of glossy privet fruit, 5g of Chinese angelica, 3g of black sesame, 2g of tall gastrodia tuber, 2g of fried safflower, 2g of ginseng and 1g of tangerine peel, baking, placing in an extraction tank, adding 800ml of water, decocting for 2 hours, and soaking for 48 hours to obtain 675ml of decoction; cooling the decoction to 60 deg.C, adding yeast and acetic acid, sealing the tank for 1.5 months to obtain 660ml fermentation liquid, and filtering to obtain 645ml effective components; adding 100g carbomer into appropriate amount, swelling completely, adjusting pH to 6 with trace amount of sodium hydroxide, mixing the effective components with 1000g propylene glycol and 2000ml water, stirring, adding 80g azone, and stirring to obtain gel.

example 7

Taking 24g of dried ginger, 20g of polygonum multiflorum, 8g of scalded rhizoma drynariae, 6g of eclipta, 6g of mulberry, 6g of schisandra chinensis, 5g of glossy privet fruit, 5g of angelica, 2g of black sesame, 2g of gastrodia elata, 2g of safflower, 2g of ginseng and 2g of dried orange peel, baking, putting the baked ginger into an extraction tank, adding 900ml of water, decocting for 2 hours, and soaking for 48 hours to obtain 640ml of decoction; cooling the decoction to 60 deg.C, adding yeast and acetic acid, sealing the tank for 2 months to obtain 635ml fermentation liquid; adding trace amount of salt and 1% edible rice into the fermentation liquid, brewing vinegar essence and edible essence, filtering to obtain 610ml effective components, and bottling to obtain hair growth promoting liquid.

Example 8

Taking 25g of dried ginger, 25g of polygonum multiflorum, 8g of rhizoma drynariae, 8g of eclipta, 8g of mulberry, 8g of schisandra chinensis, 8g of glossy privet fruit, 8g of angelica, 5g of black sesame, 5g of gastrodia elata, 5g of safflower, 5g of ginseng and 3g of dried orange peel, baking, putting the baked materials into an extraction tank, adding 1100ml of water, decocting for 1 hour, and soaking for 24 hours to obtain 890ml of decoction; cooling the decoction to 50 deg.C, adding yeast and acetic acid, sealing the tank for 2 months to obtain 883ml fermentation liquid; the fermentation liquor is added with trace salt and 1% edible rice to brew vinegar essence and edible essence, and 845ml of effective components are obtained after filtration. Uniformly mixing 40g of ethanol and 40g of linoleic acid glyceride, adding the effective components, and fully dissolving to obtain uniform and transparent microemulsion; weighing 10g of gel matrix, adding into 50g of water, stirring, standing, swelling, mixing, slowly adding the microemulsion, adding 5g of azone, stirring, and adjusting pH to 7 to obtain the microemulsion gel.

The beneficial effects of the traditional Chinese medicine composition in hair growth are further illustrated by the following test examples.

Population test example:

1. test drugs and subjects

The invention comprises the following steps: example 6 gel preparation

Comparative drug 1: octopus 101 hair tonic (Beijing Octopus 101 science and technology Co., Ltd., approved document: G20140397)

Comparative drug 2: finasteride tablets (Bao Fang, Hangzhou Shishadong pharmaceutical Co., Ltd., national Standard: J20150142)

The test records 96 patients with 31-65 years old alopecia areata, alopecia totalis and alopecia, wherein 50 men and 46 women are divided into three groups, and the hair growth liquid group comprises 39 men and 23 women; 101 control group of 39 persons, 16 persons male, 23 persons female; finasteride group 18, all males (finasteride tablets were only indicated for male baldness).

2. Test method

The invention group: each patient washed and wiped dry hair, then 10mL of the hair tonic prepared in example 4 was applied to the scalp, and kneaded for 3-5 minutes once a day for six months (three months for baldness, hair was allowed to grow out, and six months for hair fixation).

101 control group: each patient washed and wiped dry hair, then applied 10mL of comparative drug 1 octopus 101 hair tonic to the scalp, massaged for 3-5 minutes twice a day for six months.

Finasteride group: each male patient was administered once a day, one tablet (1mg) at a time, and the comparative drug 2 finasteride was administered orally for six months.

3. Criteria for evaluating therapeutic effects

1) The effect is shown: stopping hair loss and regrowing hair in the hairless area;

2) The method has the following advantages: stopping alopecia, and growing hair again in part of hairless area;

3) And (4) invalidation: the hair loss is not improved, and no new hair grows on the hair-free part.

4. Therapeutic results

The overall treatment after three months of treatment was as follows:

Group of	Treatment of diseases	Show effect	Is effective	invalidation	Total effective rate
						Group of the invention	39	16	17	6	84.6％
101 control group	39	12	14	13	67.7％
						Finasteride group	18	0	4	14	22.2％

The overall treatment after six months of treatment was as follows:

Group of	Treatment of diseases	Show effect	Is effective	Invalidation	Total effective rate
						Group of the invention	39	28	9	2	94.8％
101 control group	39	19	11	9	76.9％
						Finasteride group	18	4	8	6	66.7％

After the six-month treatment period, the follow-up visit after six months is as follows:

The results show that the hair growth liquid is used for hair growth, has the advantages of quick response, short treatment course, high cure rate and low recurrence rate compared with the traditional external traditional Chinese medicine hair growth agent and western medicines, and is worthy of clinical popularization and application.

Individual test examples:

case 1: in a certain season, women are 48 years old, have serious hair loss at the top of the head, have a large amount of hair loss and have a baldness tendency. Patients take a large amount of medicines for conditioning after self-describing, but the problem of alopecia is not improved. When the patient uses the hair growth liquid prepared in the embodiment 4 of the invention once a day in 2018 and 7 months, the hair loss problem is greatly improved within one week, new hair grows up after the hair growth liquid is used for one month, and the hair density is normal after the hair growth liquid is continuously used for three months. The disease does not relapse after the later return visit. A comparison before and after use is shown in fig. 1.

Case 2: song Dynasty, women, age 33, postpartum alopecia, oily hair, patients self-reported that hair loss is most obvious after shampooing, no obvious improvement is realized in the period of nearly one year, dreaminess, night sweat and insomnia are caused. After the patient uses the hair growth liquid prepared in the embodiment 4 of the invention once a day in 7 months in 2018, the hair loss problem is improved within one week, and the hair density is normal after the hair growth liquid is continuously used for one month. The disease does not relapse after the later return visit. A comparison before and after use is shown in fig. 2.

case 3: li Jie, male, 55 years old, severe baldness, extremely little hair on the top of the head and the back of the brain, the patient has had a self-reported disease for more than 10 years, and the effect is not seen when taking various medicines and using the octopus 101 hair-growing agent. When the hair growth lotion prepared in example 4 of the invention is used by a patient in 2018 and 8 months, the hair loss problem is improved within one week, and villi grow within one month. The medicine can not be used every day for various reasons, the medicine is not used until two months, the medicine is used for three or five days after half a month, the hair quantity of the head part and the head part is obviously increased after six months, and the medicine is continuously used. A comparison before and after use is shown in fig. 3.

Case 4: zhangqi, male, 32 years old, the pattern of alopecia is alopecia areata, which is characterized in that a piece of hair on the side of the head is completely lost, the family genetic history exists, and the alopecia is increased or decreased after a plurality of Chinese and western medicines are taken. After the hair growth liquid prepared in the example 7 of the invention is used by a patient in 2018 and 9 months, the scalp begins to grow villi once a day, after the hair growth liquid is used for six months, the hair on the original bald part is blackened and thickened, and no relapse occurs after the hair growth liquid is revisited.

The above description is only for the specific embodiments of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art can easily conceive of the changes or substitutions within the technical scope of the present invention, and all the changes or substitutions should be covered within the scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the appended claims.

Claims

1. The traditional Chinese medicine composition for hair growth is characterized by comprising the following raw material medicines in parts by weight: 10-30 parts of ginger, 10-30 parts of polygonum multiflorum, 1-10 parts of rhizoma drynariae, 1-10 parts of eclipta, 1-10 parts of mulberry, 1-10 parts of schisandra chinensis, 1-10 parts of glossy privet fruit, 1-10 parts of angelica sinensis, 1-10 parts of black sesame, 1-8 parts of gastrodia elata, 1-8 parts of safflower, 1-8 parts of ginseng and 1-6 parts of dried orange peel.

2. The traditional Chinese medicine composition according to claim 1, wherein the traditional Chinese medicine composition comprises the following raw material medicines in parts by weight: 15-25 parts of ginger, 15-25 parts of polygonum multiflorum, 2-8 parts of drynaria rhizome, 2-8 parts of eclipta, 2-8 parts of mulberry, 2-8 parts of schisandra chinensis, 2-8 parts of glossy privet fruit, 2-8 parts of angelica, 1-5 parts of black sesame, 1-5 parts of gastrodia elata, 1-5 parts of safflower, 1-5 parts of ginseng and 1-3 parts of dried orange peel;

Preferably, the traditional Chinese medicine composition comprises the following raw material medicines in parts by weight: 18 parts of ginger, 16 parts of fleece-flower root, 5 parts of rhizoma drynariae, 5 parts of yerbadetajo herb, 5 parts of mulberry fruit, 5 parts of Chinese magnoliavine fruit, 5 parts of glossy privet fruit, 5 parts of Chinese angelica, 2 parts of black sesame, 2 parts of gastrodia elata, 2 parts of safflower, 2 parts of ginseng and 1 part of dried orange peel;

Preferably, the traditional Chinese medicine composition comprises the following raw material medicines in parts by weight: 20 parts of ginger, 20 parts of polygonum multiflorum, 6 parts of rhizoma drynariae, 6 parts of yerbadetajo herb, 6 parts of mulberry fruit, 6 parts of schisandra chinensis, 6 parts of glossy privet fruit, 6 parts of angelica, 2 parts of black sesame, 2 parts of gastrodia elata, 2 parts of safflower, 2 parts of ginseng and 1 part of dried orange peel;

Preferably, the traditional Chinese medicine composition comprises the following raw material medicines in parts by weight: 24 parts of ginger, 18 parts of polygonum multiflorum, 6 parts of rhizoma drynariae, 6 parts of eclipta, 6 parts of mulberry, 5 parts of schisandra chinensis, 5 parts of glossy privet fruit, 5 parts of angelica, 3 parts of black sesame, 2 parts of gastrodia elata, 2 parts of safflower, 2 parts of ginseng and 1 part of dried orange peel.

3. The traditional Chinese medicine composition according to claim 1, characterized by one or more of the following 1) to 7):

1) The ginger is dried ginger;

2) The fleece-flower root is prepared fleece-flower root;

3) The safflower is fried safflower or safflower charcoal or vinegar safflower;

4) the mulberry is dried mulberry;

5) The fructus Ligustri Lucidi is wine fructus Ligustri Lucidi or steamed fructus Ligustri Lucidi;

6) The angelica is wine angelica;

7) The rhizoma Drynariae is scalded rhizoma Drynariae.

4. The Chinese medicinal composition according to claim 1, further comprising a pharmaceutically acceptable adjuvant or a cosmetic base.

5. The traditional Chinese medicine composition according to claim 1, wherein the traditional Chinese medicine composition can be prepared into an external preparation or a cosmetic, and preferably, the preparation or the cosmetic is one of liniment, nano-emulsion, gel, transdermal patch, powder, lotion, aerosol, spray, micro-emulsion gel, patch, liposome gel, foam preparation, hair conditioner, hair spray, shampoo, essence and hair tonic.

6. A method for preparing the traditional Chinese medicine composition of claim 1 is characterized in that the raw materials are dried and ground into powder and evenly mixed to obtain effective components; or extracting the raw material medicines with water to obtain the effective components of the traditional Chinese medicine composition; or extracting the raw material medicines with water and fermenting to obtain the effective components of the traditional Chinese medicine composition.

7. The method of claim 6, wherein:

8. The preparation method according to claim 6, wherein one or more of salt, acetin and flavoring essence can be added, preferably, the acetin is prepared from 1% edible rice.

9. The production method according to claim 6, characterized by the following 1) or 2):

1) baking the raw material medicines in parts by weight, putting the baked raw material medicines into an extraction tank, adding water which is 10 times of the total weight of the raw material medicines, decocting for 1 hour, and soaking for 24 hours to obtain effective components;

2) Baking the raw material medicines in parts by weight, putting the baked raw material medicines into an extraction tank, adding water which is 8-10 times of the total weight of the raw material medicines, decocting for 1-2 hours, and soaking for 24 hours to obtain a decoction; cooling the decoction to 30-50 deg.C, adding yeast and acetic acid, sealing the tank for 1-2 months to obtain fermentation liquid, and filtering to obtain effective components.

10. The use of a Chinese medicinal composition according to any one of claims 1-5 in the preparation of a hair growth promoting medicament.