CN112826875A - Traditional Chinese medicine hair growing cream for treating alopecia and preparation method thereof - Google Patents
Traditional Chinese medicine hair growing cream for treating alopecia and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to the field of hair growing cream, and particularly relates to traditional Chinese medicine hair growing cream for treating alopecia and a preparation method thereof. The traditional Chinese medicine hair growing cream comprises traditional Chinese medicine dry powder and dispersion liquid for dispersing the traditional Chinese medicine dry powder, wherein the traditional Chinese medicine dry powder is mainly formed by mixing and drying traditional Chinese medicine composition and lipid; the traditional Chinese medicine composition comprises the following components: rhizoma Drynariae, Sal, radix Saposhnikoviae, folium Mori, fructus Vitics Simplicifoliae, folium Pini and cimicifugae rhizoma; the dispersion includes a surfactant and water. The preparation method comprises the following steps: micronizing the components of the Chinese medicinal composition respectively to obtain powder, mixing to obtain Chinese medicinal powder, adding oil, soybean lecithin and nonionic surfactant to obtain suspension, and drying to obtain Chinese medicinal dry powder; dissolving the components for preparing the dispersion liquid in water, and homogenizing to obtain the dispersion liquid; and uniformly stirring the traditional Chinese medicine dry powder and the dispersion liquid, and concentrating to obtain the traditional Chinese medicine hair growing cream. The traditional Chinese medicine hair growing cream prepared according to the method has good effects of treating alopecia and promoting hair growth.
Description
Technical Field
The invention relates to a traditional Chinese medicine hair growing cream, in particular to a traditional Chinese medicine hair growing cream for treating alopecia and a preparation method thereof.
Background
Alopecia is a very common phenomenon in people, and serious alopecia not only affects the appearance of appearance instruments, but also suggests some problems possibly occurring in organisms. In recent years, this phenomenon has been gradually advancing toward the younger. The factors of endocrine disturbance, excessive use of hairdressing products, excessive pressure, diet, diseases and the like are the first causes of alopecia. These factors are often manifold and often difficult to predict and control, and thus hair loss is a problem that many people are always troubling.
TCM holds that "when qi and blood are excessive, mustache will cause mustache and white blood will cause failure of qi and blood, which must be treated by the theory. The hair is the excess of blood and can be deficient or excessive. Deficiency syndrome is caused by deficiency of liver and kidney, failure of blood to nourish and pathogenic wind attacking the body due to deficiency; this is an excess syndrome due to stagnation of liver qi, resulting in qi stagnation, blood stasis and malnutrition. Therefore, the local environment of the scalp, qi stagnation and blood stasis are also one of the most important reasons for alopecia.
In the invention patent with the patent application number of 201710374713.8, a novel postpartum recovery shampoo preparation is disclosed, which is prepared from the following raw materials: rhizoma ligustici wallichii, raw arisaema, raw rhizoma typhonii, fistular onion stalk, fresh ginger, angelica sinensis, schizonepeta, angelica dahurica, asarum, soapberry, frosted mulberry leaf, chinaberry fruit, catechu, nux vomica, chaulmoogra seed, cochinchina momordica seed, dampness transforming medicine, crinis carbonisatus, ligusticum, duckweed, burdock, salix chebula, chastetree fruit, equisetum, schizonepeta, divaricate saposhnikovia root, mint leaf, gardenia kernel, scutellaria baicalensis, platycodon grandiflorum and fructus forsythiae. Although the product has a certain hair growth function, the main function is to repair hair, and the hair growth effect is not good.
The invention patent with application number 201510699882.X discloses a hair growing film and a preparation method thereof, and the application date is as follows: 2015-10-26, a hair growth promoting film is introduced, which is prepared from a Usimma grass juice, an aloe gel, a polygonum multiflorum water extract, seaweed gel particles and the like according to a proportion. However, the hair growth promoting film may have problems in terms of use compliance such as pungent odor during use.
At present, hair growth liquid products are various in variety, are mainly used for shaping or setting, and are rarely developed and applied to functional products for blackening hair, preventing hair loss and the like.
Disclosure of Invention
Technical problem to be solved
In order to solve the problems in the prior art, the invention provides a traditional Chinese medicine hair growing cream which is externally used and can effectively promote hair growth and a preparation method thereof.
(II) technical scheme
In order to achieve the purpose, the invention adopts the main technical scheme that:
a traditional Chinese medicine hair tonic cream comprises traditional Chinese medicine dry powder and dispersion liquid for dispersing the traditional Chinese medicine dry powder, wherein the traditional Chinese medicine dry powder is mainly prepared by mixing and drying traditional Chinese medicine composition and lipid-containing auxiliary materials; the dispersion comprises the following components: a surfactant and water. The traditional Chinese medicine composition comprises the following components: rhizoma Drynariae and salt.
Wherein the rhizoma Drynariae is rhizome of Epilobium fern of Drynariae of Drynariaceae. Bitter taste and warm nature. Enter liver and kidney meridians. Regulating blood, dredging collaterals, nourishing liver and kidney, and replenishing essence and blood.
The salt is sea salt, mineral salt, lake salt, well salt, etc., and contains NaCl as main component and trace elements including Mg, Al, Si, K, Ca, Fe, S, etc. except NaCl, the functional groups are mainly in the form of sulfate radical, carbonate radical, silicate radical, hydroxyl radical in free and combined form, etc. Salty and cold. It enters heart and kidney meridians. Cool blood, improve vision. The present invention is preferably a halite.
The traditional Chinese medicine composition formed by the formula is used for treating alopecia and promoting hair growth, does not relate to nationally protected animal and plant mineral varieties, is natural in raw material source, is safe, nontoxic, mild, effective, green and environment-friendly.
Wherein the traditional Chinese medicine dry powder is solid lipid nanoparticles, and the particle size of the prepared nanoparticles is 160-170 nm.
According to the scheme, the drynaria rhizome which does not have the effect of treating alopecia is prepared into the solid lipid nanoparticles after being compatible with the salt, and the solid lipid nanoparticles are dispersed and dissolved in the dispersion liquid containing the surfactant to form the hair growing cream which has good effects of treating alopecia and promoting hair growth, and the effect is unexpected.
In the preferable scheme of the traditional Chinese medicine hair growing cream, the traditional Chinese medicine composition also comprises one or the combination of more than two of the following components: radix Saposhnikoviae, folium Mori, fructus Vitics Simplicifoliae, folium Pini and cimicifugae rhizoma.
Ledebouriella root, a root of the plant Saposhnikovia divaricata (Turcz.) switzerland, of the family umbelliferae, scheschchk. Pungent and sweet with mild temperature. It enters bladder, liver and spleen meridians. Dispel wind and relieve exterior syndrome, subdue dampness and alleviate pain, stop spasm.
Mulberry leaves, which are leaves of mulberry trees belonging to deciduous arbors of Moraceae, are bitter, sweet and cold in nature. It enters lung and liver meridians. Promote blood circulation to cool blood, dispel wind and clear heat.
Fructus Vitics Simplicifoliae is dried mature fruit of Vitex trifoliata Vitex trifolia L.var. Pungent, bitter and slightly cold. It enters bladder, liver and stomach meridians. Disperse wind-heat, clear head and eyes.
Pine leaves are needles of Pinus armandi Franch, Pinus taiwanensis Hayata, Pinus massoniana lamb, Pinus thunbergii Parl, Pinus tabulaeformis Carr, Pinus yunnanensis Franch, Pinus koraiensis Koraiensis Sieb et al. Bitter and warm. It enters heart and spleen meridians. Dispel wind and dry dampness, kill parasites and relieve itching, activate blood and tranquilize mind.
Cimicifuga foetida is dried rhizome of Cimicifuga trifoliata Cimicifuga herculeolia Kom., Cimicifuga dahurica (Turcz.) Maxim., Cimicifuga xing A Dahurica (Turcz.) or Cimicifuga foetida L. Pungent, slightly sweet and slightly cold. It enters lung, spleen, stomach and large intestine meridians. Relieve exterior syndrome, promote eruption, clear heat and remove toxicity, and promote yang qi.
The solid lipid nanoparticles are prepared by further matching the divaricate saposhnikovia root, the mulberry leaves, the fructus viticis, the pine needles or the cimicifuga foetida which does not have the effect of treating the alopecia with the rhizoma drynariae and the salt, and the solid lipid nanoparticles are dispersed and dissolved in the dispersion liquid containing the surfactant to form the hair growing cream which has good effects of treating the alopecia and promoting the hair growth, and the effect is unexpected.
In a preferable scheme of the traditional Chinese medicine hair growing cream, the traditional Chinese medicine composition comprises the following components in parts by weight: 1-20 parts of rhizoma drynariae, 1-20 parts of salt, 1-20 parts of divaricate saposhnikovia root, 1-10 parts of mulberry leaf, 1-20 parts of fructus viticis, 1-10 parts of pine needle and 1-10 parts of cimicifugae foetidae.
According to the scheme, the compatibility of the components in the traditional Chinese medicine composition is optimal through the proportion, and the finally prepared hair growing cream has stronger effects of treating alopecia and growing hair.
In the preferable technical scheme of the traditional Chinese medicine hair growing cream, the auxiliary materials also comprise the following components, namely soybean lecithin and a nonionic surfactant; the auxiliary materials comprise the following components in parts by weight: 1-50 parts of lipid, 1-50 parts of soybean lecithin and 1-50 parts of nonionic surfactant.
The lipid is preferably glyceryl tristearate and the nonionic surfactant is preferably poloxamer 188.
In the preferable technical scheme of the traditional Chinese medicine hair growing cream, the surfactant comprises 0.1-0.5 part of sodium benzoate by weight, and the dispersion liquid also comprises the following components by weight: 0.5-2 parts of EDTA tetrasodium, 10-20 parts of glycerin, 10-20 parts of sodium hyaluronate, 20-40 parts of horse fat, 10-20 parts of silk hydrolysate and 0.1-1 part of citric acid; further, the dispersion liquid also comprises 0.1-0.5 weight part of essence.
In the scheme, the Sodium Benzoate and Sodium Benzoate play a role in corrosion prevention and bacteriostasis, are broad-spectrum antimicrobial reagents and have good effects on saccharomycetes, mycete and the like. The raw material is white particles or crystalline powder, is easily soluble in water and ethanol, and is slightly soluble in non-polar solvents such as ether and acetone;
tetrasodium EDTA, also known as tetrasodium salt of ethylenediaminetetraacetic acid, is a white powder, is easily soluble in water, and is used as a chelating agent in a hair tonic cream;
glycerin, also known as glycerol, is a colorless, odorless, sweet viscous liquid. Boiling point 290 deg.C, melting point 17.9 deg.C, relative density 1.2613. Can be infinitely miscible with water, and the anhydrous glycerin has strong water absorption. The hair tonic cream is used as a cosolvent;
sodium hyaluronate is an acidic mucopolysaccharide. Has special water retention function, and is the natural moisturizing factor with the best moisturizing effect in the natural world at present;
the horse fat is fat extracted from horsehair parts on a horse body, contains rich nutrients and can make skin more tender;
the silk hydrolysate is hydrolysate of natural silk, is a composition containing abundant amino acids, peptides and proteins, and can promote skin improvement;
the essence mainly comprises various natural spices and essential oil, mainly comprises thymol and storax, and has various fragrance types, and the essence referred in the patent comprises essences of all types;
the citric acid is buffer in hair growth promoting cream, and pure citric acid is colorless transparent crystal or white powder, has no odor and attractive sour taste, and can be used for regulating pH value of hair growth promoting cream.
A preparation method of traditional Chinese medicine hair growing cream comprises the following steps:
s1: preparing Chinese medicinal dry powder, micronizing each component of the Chinese medicinal composition into powder, mixing to obtain Chinese medicinal powder, adding oil, soybean lecithin and nonionic surfactant to obtain suspension, and drying to obtain Chinese medicinal dry powder;
s2: preparing a dispersion liquid, namely dissolving all components prepared into the dispersion liquid in water, and homogenizing to obtain the dispersion liquid;
s3: and (4) uniformly stirring the traditional Chinese medicine dry powder and the dispersion liquid in the step (S1), and concentrating to obtain the traditional Chinese medicine hair growing cream.
In the preferable technical scheme of the preparation method, in the step S1, lipid is added into the traditional Chinese medicine powder to prepare an oil phase; mixing soybean lecithin and nonionic surfactant, and adding water to obtain water phase; adding the oil phase into the water phase, sequentially shearing, performing ultrasonic treatment and homogenizing treatment to obtain suspension, and freeze-drying to obtain Chinese medicinal dry powder.
According to the preferable technical scheme of the preparation method, the traditional Chinese medicine powder is added with lipid and then heated to 60-100 ℃ to obtain an oil phase; mixing the soybean lecithin and a nonionic surfactant, adding water, and heating to 60-100 ℃ to obtain a water phase; the shearing is high-speed shearing, and the rotating speed is as follows: 10000-20000 rpm; the power of ultrasonic treatment is 500-1000W, the frequency is 20-60 kHz, and the treatment time is 1-20 min; the homogenizing time is 1-10 min; pre-freezing the suspension at-15 to 0 ℃ for 1 to 10 hours, and then freeze-drying the suspension at-40 to-80 ℃ for 12 to 24 hours to obtain the traditional Chinese medicine dry powder.
In the preferable technical scheme of the preparation method of the invention, in the step S1, the lipid is tristearin, and the nonionic surfactant is poloxamer 188.
In the preferable technical scheme of the preparation method, in the step S3, the rotation speed of homogenizing and stirring is 10-100 rpm, and the time is 10-60 min; the concentration temperature is 20-60 ℃, and the time is 1-5 h.
(III) advantageous effects
The invention has the beneficial effects that:
1. the invention is formed by taking the theory of traditional Chinese medicine as guidance and carefully composing the prescription. The bone in the formula is broken and supplemented, the taste is bitter, the property is warm, and the formula can dredge the scalp, dispel the depression, promote the blood circulation and supply nutrition for the growth of hair follicles; fructus Viticis is pungent, bitter and cold in property, and can dispel wind and head heat, so it has the actions of clearing heat, dispelling wind and stopping oxygen. The two are monarch drugs, and can dispel head qi stagnation and blood stasis caused by various reasons regardless of cold and heat. The mulberry leaves are bitter and sweet in taste, cold in nature, bacteriostatic, anti-inflammatory and heat-clearing; the salt can soften hard mass and dissipate stagnation, and can diminish inflammation and clear heat; the pine needles are bitter, astringent and warm, have the functions of dispelling wind, activating blood circulation, detoxifying, killing parasites and relieving itching, and can promote blood circulation and improve the functions of capillary vessels. The three medicines are used as ministerial medicines, and the qi-tonifying and blood stasis-removing effects of the two monarch medicines are increased. The divaricate saposhnikovia root is pungent, sweet and slightly warm in property, and can expel wind, release exterior, dispel cold, relieve itching, remove dampness and relieve pain; the rhizoma cimicifugae is pungent, sweet and slightly cold in property, pungent can release exterior syndrome, slightly cold can clear heat and remove damp heat and greasiness on the surface of the scalp, further plays the roles of dispelling cold and diminishing inflammation, and promoting blood circulation and removing meridian obstruction in the whole formula, and is used as an adjuvant drug together. The traditional Chinese medicine composition has the effects of dispelling cold, clearing heat, dispelling wind, removing dampness, relieving itching and detoxifying, enables the scalp environment to achieve the healthy states of dispelling cold, removing heat, dispelling wind, removing dampness, and relieving itching, improves the living environment condition, and enables the hair in the scalp environment to naturally stop alopecia, grow more and grow healthily.
2. The invention uses the principle of oil/water phase, and uses liposome and surfactant to prepare solid lipid nanoparticles, thus enhancing the stability of active ingredients of traditional Chinese medicine and realizing the effects of stable release and sustained release. The particle size of the prepared nanoparticles is 160-170 nm, so that the small size of the nanoparticles greatly increases the contact surface area of the nanoparticles with hair and scalp, and the action time is correspondingly improved. By the characteristics of the liposome, the hair growth promoting liquid can form a film on the surface of the scalp and encapsulate the hair to reduce the water loss, and meanwhile, the good adhesiveness is not lost, so that the traditional Chinese medicine components of the hair growth promoting liquid are beneficial to percutaneous absorption, and the bioavailability is improved.
3. The traditional Chinese medicine hair growing cream provided by the invention can be used for maintaining scalp and hair and treating alopecia. Experiments prove that: the traditional Chinese medicine has an obvious treatment effect on alopecia and an exact curative effect, and the effective rate is 70-95%.
4. The preparation method of the traditional Chinese medicine hair-growing cream combines the traditional Chinese medicine theory and the traditional Chinese medicine prescription with the modern scientific and technical means, overcomes the defects of complicated process, low utilization rate, inconvenient use and the like of the traditional process, replaces the high-efficiency preparation process, and ensures that the product of the invention is easier to be integrated into the life of people and can play the role of the product.
Detailed Description
For a better understanding of the present invention, reference will now be made in detail to the present invention by way of specific embodiments thereof.
Example 1: the invention relates to a traditional Chinese medicine hair growing ointment for treating alopecia, which comprises a main medicine containing a traditional Chinese medicine composition and a dispersion liquid, wherein the traditional Chinese medicine composition comprises the following components in parts by weight: 1 part of rhizoma drynariae and 20 parts of green salt. The dispersion comprises the following components in parts by weight: 0.1 part of sodium benzoate, 2 parts of EDTA tetrasodium, 15 parts of glycerin, 10 parts of sodium hyaluronate, 40 parts of horse fat, 13 parts of silk hydrolysate, 0.1 part of essence and 1 part of citric acid.
Example 2: the invention relates to a traditional Chinese medicine hair growing ointment for treating alopecia, which comprises a main medicine containing a traditional Chinese medicine composition and a dispersion liquid, wherein the traditional Chinese medicine composition comprises the following components in parts by weight: 20 parts of rhizoma drynariae and 1 part of green salt. The dispersion comprises the following components in parts by weight: 0.1 part of sodium benzoate, 2 parts of EDTA tetrasodium, 15 parts of glycerin, 10 parts of sodium hyaluronate, 40 parts of horse fat, 13 parts of silk hydrolysate, 0.1 part of essence and 1 part of citric acid.
Example 3: the invention relates to a traditional Chinese medicine hair growing ointment for treating alopecia, which comprises a main medicine containing a traditional Chinese medicine composition and a dispersion liquid, wherein the traditional Chinese medicine composition comprises the following components in parts by weight: 16 parts of rhizoma drynariae and 15 parts of green salt. The dispersion comprises the following components in parts by weight: 0.1 part of sodium benzoate, 2 parts of EDTA tetrasodium, 15 parts of glycerin, 10 parts of sodium hyaluronate, 40 parts of horse fat, 13 parts of silk hydrolysate, 0.1 part of essence and 1 part of citric acid.
Example 4:
the invention relates to a traditional Chinese medicine hair growing ointment for treating alopecia, which comprises a main medicine containing a traditional Chinese medicine composition and a dispersion liquid, wherein the traditional Chinese medicine composition comprises the following components in parts by weight: 16 parts of rhizoma drynariae, 1 part of green salt, 20 parts of divaricate saposhnikovia root, 5 parts of mulberry leaf, 1 part of fructus viticis, 10 parts of pine needle and 6 parts of cimicifugae foetidae. The dispersion comprises the following components in parts by weight: 0.1 part of sodium benzoate, 2 parts of EDTA tetrasodium, 15 parts of glycerin, 10 parts of sodium hyaluronate, 40 parts of horse fat, 13 parts of silk hydrolysate, 0.1 part of essence and 1 part of citric acid.
The preparation method of the traditional Chinese medicine hair growing cream for treating alopecia comprises the following steps:
s1: the preparation of the dry powder of the traditional Chinese medicine,
(1) respectively carrying out superfine grinding on the components in the traditional Chinese medicine composition for 60s, sieving by a 60-mesh sieve to obtain powder of each component, mixing and stirring for 30min according to the corresponding parts by weight, adding 25 parts by weight of glyceryl tristearate, and heating to 60 ℃ to obtain an oil phase;
(2) taking 50 parts by weight of soybean lecithin and 35 parts by weight of poloxamer 188, adding 1 part by weight of water, and heating to 100 ℃ to obtain a water phase;
(3) adding the oil phase into the water phase, shearing at 15000rpm for 1min, ultrasonic treating with power of 1000W and frequency of 40kHz for 1min, and homogenizing at 60000psi under high pressure for 5min to obtain suspension; pre-freezing the suspension at-15 deg.C for 10 hr, and lyophilizing at-45 deg.C for 12 hr to obtain Chinese medicinal dry powder.
S2: preparing a dispersion liquid: dissolving the components in the dispersion liquid in corresponding weight parts in deionized refined water 100 parts, homogenizing at 3000rpm for 80s with homogenizer, and repeating for 1 time;
s3: and (4) mixing the dispersion liquid obtained in the step (S2) and the dry Chinese medicine powder obtained in the step (S1) in a vertical stirrer, and stirring at 100rpm for 30 min. Taking out, placing into a concentrating machine, concentrating at 20 deg.C for 5 hr to obtain Chinese medicinal hair growth promoting paste.
Example 5:
the invention relates to a traditional Chinese medicine hair growing ointment for treating alopecia, which comprises a main medicine containing a traditional Chinese medicine composition and a dispersion liquid, wherein the traditional Chinese medicine composition comprises the following components in parts by weight: 1 part of rhizoma drynariae, 20 parts of green salt, 16 parts of divaricate saposhnikovia root, 1 part of mulberry leaf, 20 parts of fructus viticis, 6 parts of pine needle and 1 part of cimicifugae foetidae. The dispersion comprises the following components in parts by weight: 0.5 part of sodium benzoate, 1.3 parts of EDTA tetrasodium, 10 parts of glycerin, 20 parts of sodium hyaluronate, 29 parts of horse fat, 10 parts of silk hydrolysate, 0.5 part of essence and 0.6 part of citric acid.
The preparation method of the traditional Chinese medicine hair growing cream for treating alopecia comprises the following steps:
s1: the preparation of the dry powder of the traditional Chinese medicine,
(1) respectively carrying out superfine grinding on the components in the traditional Chinese medicine composition for 30s, sieving the powder with a 200-mesh sieve to obtain powder of each component, mixing and stirring the powder for 25min according to the corresponding parts by weight, adding 1 part by weight of glyceryl tristearate, and heating to 100 ℃ to obtain an oil phase;
(2) taking 25 parts by weight of soybean lecithin and 1 part by weight of poloxamer 188, adding 100 parts by weight of water, and heating to 70 ℃ to obtain a water phase;
(3) adding the oil phase into the water phase, shearing at 10000rpm for 10min, performing ultrasonic treatment at power of 700W and frequency of 20kHz for 20min, and homogenizing at 40000psi for 1min to obtain suspension; pre-freezing the suspension at 0 deg.C for 6 hr, and lyophilizing at-40 deg.C for 24 hr to obtain dry powder of Chinese medicinal materials.
S2: preparing a dispersion liquid: dissolving the components in the dispersion liquid in corresponding weight parts in 1000 parts deionized refined water, homogenizing at 2000rpm for 30s with a homogenizer, and repeating for 5 times;
s3: and (4) mixing the dispersion liquid obtained in the step (S2) and the dry Chinese medicine powder obtained in the step (S1) in a vertical stirrer, and stirring at 50rpm for 10 min. Taking out, placing into a concentration machine set, concentrating at 60 deg.C for 3 hr to obtain Chinese medicinal hair growth promoting paste.
Example 6:
the invention relates to a traditional Chinese medicine hair growing ointment for treating alopecia, which comprises a main medicine containing a traditional Chinese medicine composition and a dispersion liquid, wherein the traditional Chinese medicine composition comprises the following components in parts by weight: 20 parts of rhizoma drynariae, 15 parts of green salt, 1 part of divaricate saposhnikovia root, 10 parts of mulberry leaf, 15 parts of fructus viticis, 1 part of pine needle and 10 parts of rhizoma cimicifugae. The dispersion comprises the following components in parts by weight: 0.3 part of sodium benzoate, 0.5 part of EDTA tetrasodium, 20 parts of glycerin, 15 parts of sodium hyaluronate, 20 parts of horse fat, 20 parts of silk hydrolysate, 0.3 part of essence and 0.1 part of citric acid.
The preparation method of the traditional Chinese medicine hair growing cream for treating alopecia comprises the following steps:
s1: the preparation of the dry powder of the traditional Chinese medicine,
(1) respectively carrying out superfine grinding on the components in the traditional Chinese medicine composition for 90s, sieving the powder with a 130-mesh sieve to obtain powder of each component, mixing and stirring the powder for 10min according to the corresponding parts by weight, adding 50 parts by weight of glyceryl tristearate, and heating to 70 ℃ to obtain an oil phase;
(2) taking 1 part by weight of soybean lecithin and 50 parts by weight of poloxamer 188, adding 50 parts by weight of water, and heating to 60 ℃ to obtain a water phase;
(3) adding the oil phase into the water phase, shearing at 20000rpm for 5min, treating with 500W ultrasonic wave with frequency of 60kHz for 15min, and homogenizing at 20000psi for 10min to obtain suspension; pre-freezing the suspension at-6 deg.C for 1 hr, and lyophilizing at-80 deg.C for 18 hr to obtain dry powder of Chinese medicinal materials.
S2: preparing a dispersion liquid: dissolving the components in the dispersion liquid in corresponding weight parts in deionized refined water in 800 parts, homogenizing at 1000rpm for 120s with a homogenizer, and repeating for 3 times;
s3: and (4) mixing the dispersion liquid obtained in the step (S2) and the dry Chinese medicine powder obtained in the step (S1) in a vertical stirrer, and stirring at 10rpm for 60 min. Taking out, putting into a concentrating machine set, concentrating at 45 deg.C for 1 hr to obtain Chinese medicinal hair growth promoting paste.
Example 7:
the invention relates to a traditional Chinese medicine hair growing ointment for treating alopecia, which comprises a main medicine containing a traditional Chinese medicine composition and a dispersion liquid, wherein the traditional Chinese medicine composition comprises the following components in parts by weight: 1 part of rhizoma drynariae, 1 part of salt, 1 part of radix sileris, 1 part of mulberry leaf, 1 part of fructus viticis, 1 part of pine needle and 1 part of cimicifugae foetidae. The dispersion comprises the following components in parts by weight: 0.1 part of sodium benzoate, 0.5 part of EDTA tetrasodium, 10 parts of glycerin, 10 parts of sodium hyaluronate, 20 parts of horse fat, 10 parts of silk hydrolysate, 0.1 part of essence and 0.1 part of citric acid.
The preparation method of the traditional Chinese medicine hair growing cream for treating alopecia comprises the following steps:
s1: the preparation of the dry powder of the traditional Chinese medicine,
(1) respectively carrying out superfine grinding on the components in the traditional Chinese medicine composition for 30s, sieving the powder with a 60-mesh sieve to obtain powder of each component, mixing and stirring the powder for 10min according to the corresponding parts by weight, adding 1 part by weight of glyceryl tristearate, and heating to 60 ℃ to obtain an oil phase;
(2) taking 1 part by weight of soybean lecithin and 1 part by weight of poloxamer 188, adding 1 part by weight of water, and heating to 60 ℃ to obtain a water phase;
(3) adding the oil phase into the water phase, shearing at 10000rpm for 1min, performing ultrasonic treatment at power of 500W and frequency of 20kHz for 1min, and homogenizing at 20000psi for 1min to obtain suspension; pre-freezing the suspension at-15 deg.C for 1h, and lyophilizing at-40 deg.C for 12h to obtain Chinese medicinal dry powder.
S2: preparing a dispersion liquid: dissolving the components in the dispersion liquid in corresponding weight parts in deionized refined water 100 parts, homogenizing at 1000rpm for 30s with a homogenizer, and repeating for 1 time;
s3: and (4) mixing the dispersion liquid obtained in the step (S2) and the dry Chinese medicine powder obtained in the step (S1) in a vertical stirrer, and stirring at 10rpm for 10 min. Taking out, placing into a concentrating machine, concentrating at 20 deg.C for 1 hr, and making into ointment to obtain Chinese medicinal hair growth promoting ointment.
Example 8:
the invention relates to a traditional Chinese medicine hair growing ointment for treating alopecia, which comprises a main medicine containing a traditional Chinese medicine composition and a dispersion liquid, wherein the traditional Chinese medicine composition comprises the following components in parts by weight: 20 parts of rhizoma drynariae, 20 parts of salt, 20 parts of divaricate saposhnikovia root, 10 parts of mulberry leaf, 20 parts of fructus viticis, 10 parts of pine needle and 10 parts of rhizoma cimicifugae. The dispersion comprises the following components in parts by weight: 0.5 part of sodium benzoate, 2 parts of EDTA tetrasodium, 20 parts of glycerin, 20 parts of sodium hyaluronate, 40 parts of horse fat, 20 parts of silk hydrolysate, 0.5 part of essence and 1 part of citric acid.
The preparation method of the traditional Chinese medicine hair growing cream for treating alopecia comprises the following steps:
s1: the preparation of the dry powder of the traditional Chinese medicine,
(1) respectively carrying out superfine grinding on the components in the traditional Chinese medicine composition for 90s, sieving the powder with a 200-mesh sieve to obtain powder of each component, mixing and stirring the powder for 30min according to the corresponding parts by weight, adding 50 parts by weight of glyceryl tristearate, and heating to 100 ℃ to obtain an oil phase;
(2) taking 50 parts by weight of soybean lecithin and 50 parts by weight of poloxamer 188, adding 100 parts by weight of water, and heating to 100 ℃ to obtain a water phase;
(3) adding the oil phase into the water phase, shearing at 20000rpm for 10min, ultrasonic treating with power of 1000W and frequency of 60kHz for 20min, and homogenizing at 60000psi under high pressure for 10min to obtain suspension; pre-freezing the suspension at 0 deg.C for 10 hr, and lyophilizing at-80 deg.C for 24 hr to obtain dry powder of Chinese medicinal materials.
S2: preparing a dispersion liquid: dissolving the components in the dispersion liquid in corresponding weight parts in 1000 parts of deionized refined water, homogenizing at 3000rpm for 120s with a homogenizer, and repeating for 5 times;
s3: and (4) mixing the dispersion liquid obtained in the step (S2) and the dry Chinese medicine powder obtained in the step (S1) in a vertical stirrer, and stirring at 100rpm for 60 min. Taking out, placing into a concentration machine set, concentrating at 60 deg.C for 5 hr to obtain Chinese medicinal hair growth promoting paste.
Example 9:
the invention relates to a traditional Chinese medicine hair growing ointment for treating alopecia, which comprises a main medicine containing a traditional Chinese medicine composition and a dispersion liquid, wherein the traditional Chinese medicine composition comprises the following components in parts by weight: 11 parts of rhizoma drynariae, 8 parts of salt, 12 parts of divaricate saposhnikovia root, 5 parts of mulberry leaf, 16 parts of fructus viticis, 4 parts of pine needle and 5 parts of rhizoma cimicifugae. The dispersion comprises the following components in parts by weight: 0.3 part of sodium benzoate, 1.2 parts of EDTA tetrasodium, 13 parts of glycerin, 11 parts of sodium hyaluronate, 30 parts of horse fat, 11 parts of silk hydrolysate, 0.3 part of essence and 0.4 part of citric acid.
The preparation method of the traditional Chinese medicine hair growing cream for treating alopecia comprises the following steps:
s1: the preparation of the dry powder of the traditional Chinese medicine,
(1) respectively carrying out superfine grinding on the components in the traditional Chinese medicine composition for 80, sieving by a 80-mesh sieve to obtain powder of each component, mixing and stirring the powder for 20min according to the corresponding parts by weight, adding 21 parts by weight of glyceryl tristearate, and heating to 75 ℃ to obtain an oil phase;
(2) taking 22 parts by weight of soybean lecithin and 37 parts by weight of poloxamer 188, adding 63 parts by weight of water, and heating to 68 ℃ to obtain a water phase;
(3) adding the oil phase into the water phase, shearing at 17000rpm for 3min, ultrasonic processing at power of 800W and frequency of 30kHz for 14min, and homogenizing at 40000psi for 5min to obtain suspension; pre-freezing the suspension at-7 deg.C for 6 hr, and lyophilizing at-60 deg.C for 20 hr to obtain Chinese medicinal dry powder.
S2: preparing a dispersion liquid: dissolving the components in the dispersion liquid in corresponding weight parts in 600 parts of deionized refined water, homogenizing at 2000rpm for 80s with a homogenizer, and repeating for 3 times;
s3: and (4) mixing the dispersion liquid obtained in the step (S2) and the dry Chinese medicine powder obtained in the step (S1) in a vertical stirrer, and stirring at 80rpm for 40 min. Taking out, placing into a concentrating machine, concentrating at 40 deg.C for 3 hr to obtain Chinese medicinal hair growth promoting paste.
The reliability and the safety of the traditional Chinese medicine hair growing cream for treating alopecia prepared by the methods of the embodiments 1 to 9 of the invention completely meet the requirements of the relevant national standards through detection.
In order to further investigate the clinical efficacy of the traditional Chinese medicine hair growing cream, 100 outpatients are selected for clinical tests, and the traditional Chinese medicine hair growing cream prepared by the invention is used for clinically treating alopecia, and the specific method and the result are as follows:
clinical treatment examples:
1. diagnostic criteria
Refer to the relevant standards in "dermatology of traditional Chinese medicine".
Removing genetic tendency, and giving priority to weak or excessive mental;
② the hair is thin, thin and soft, and can be shed for a long time or even bald, the skin of the bald area is smooth, and the fine vellus hairs can be seen;
thirdly, the symptoms such as dizziness, insomnia, poor memory, soreness and weakness of waist and knees, tinnitus, dysphoria with smothery sensation in chest, palms and soles and the like are accompanied;
fourthly, the tongue is red, the coating is little, and the pulse is thready and rapid.
2. Inclusion criteria
Meeting the diagnosis standard;
② the age is 20-65 years old;
③ the course of disease is within 5 years;
and fourthly, voluntarily receiving the test and signing an informed consent.
3. Exclusion criteria
Firstly, the Chinese and western medicines for treating the disease and other medicines which can interfere the hair growth are taken within nearly 6 months;
② patients with liver and kidney insufficiency and serious diseases accompanied with other systems;
③ patients with alopecia caused by other reasons (such as endocrine diseases such as polycystic ovary syndrome, alopecia areata, congenital alopecia totalis or congenital alopecia paucity, traumatic alopecia, chemotherapy, etc.);
women in gestation period, preparatory pregnancy, 12 months or lactation period after delivery and psychopaths;
fifthly, for those allergic to the test drugs.
4. Standard of detachment
Firstly, the medicine is not taken according to the regulation, the compliance is poor, and the judgment of the curative effect is influenced;
② incomplete test data;
finding a pregnant person during the test period;
and fourthly, the laboratory index is abnormal or other adverse events occur during the test period, and the tester can not continue the test.
5. Clinical sample size
Eligible patients were selected, with a total of 100 clinical samples of the product per example, and 50 men and women within the age range.
6. Application method
The medicine is taken twice a day, and is used when getting up to wash in the morning and before sleeping in the evening, the dosage is preferably to be applied to the head, and the massage time is five to ten minutes. One treatment course is seven days. A total of five courses of treatment were performed.
7. Standard of therapeutic effect
And (3) curing: in patients with alopecia totalis and alopecia areata, more than 90% of new hairs grow on hair at the bald part, and new vellus hairs grow at the lowest;
improvement: the growth of new vellus hairs in part and in large part;
and (4) invalidation: no new hair is produced.
8. Therapeutic results
(1) The clinical curative effect results are as follows: after treatment, 48 cases are cured, 47 cases are improved, 5 cases are not effective, and the total effective rate is 95%.
(2) New hair growth time: in the effective case of statistical observation, the patients can be found in different time periods after the medicines are taken within 0-7 days: the patient can stop alopecia, new hair is generated in 7-15 days, and hair is thickened in 15-30 days.
(3) The side effect is shown as follows: the side effect of 100 patients in the treatment process is counted, and no obvious adverse reaction occurs.
The results show that the traditional Chinese medicine hair growing cream is used for treating alopecia, has the advantages of quick response, short treatment course, high cure rate, no side effect and the like, and is worthy of clinical popularization and application.
The curative effect of the traditional Chinese medicine hair growing ointment is further verified by specific cases as follows:
case 1
In 34 years old of Wang and women, a patient has sparse hair and white hair, and various anti-hair loss products and pilatory have been tried, but the anti-hair loss products and pilatory have no obvious curative effect, high cost, physical and mental fatigue of the patient and poor mental state. Through the recommendation of people, the traditional Chinese medicine hair growing cream is used for treatment from our places. After the medicine is taken for 7 days, the patient stops baldness from the head, large white vellus hairs begin to grow at the lacking part in 7-15 days, the scalp becomes black, the yellow and white hair quality begins to gradually turn black, the mental state begins to improve, after the medicine is taken for 15 days, the yellow and white hair quality of the patient turns black and bright, the hairs are dense, the mental state is excellent, the whole person feels full of vitality, and the effect is obvious.
Case 2
Zhao, male, 45 years old, the patient began to have alopecia phenomenon 3 years ago, the back is convex, the alopecia is serious, the patient has depressed mood and low, vexation and dysphoria, no essence is collected, insomnia and dreaminess due to the alopecia, and the treatment with various anti-alopecia shampoos and Chinese and western medicines has no obvious effect. Under the recommendation of friends, the doctor visits the doctor and diagnoses the baldness, and the traditional Chinese medicine hair growing cream is used. After the medicine is applied for 7 days, the patient stops baldness from the head, large white vellus hairs begin to grow at the lacking part in 7-15 days, the scalp becomes black, the mental state starts to improve, after the medicine is applied for 15 days, the patient grows new hairs on the full head, the patient is excited, the face is ruddy, and the effect is obvious.
Case 3
When a person recommends to visit a doctor, the traditional Chinese medicine hair growing cream is used. After the medicine is applied for 7 days, the patient stops baldness from the head, large white vellus hairs begin to grow at the lacking part for 7-15 days, the scalp becomes black, after the medicine is applied for 15 days, the hair of the patient is dense, the mental state is excellent, the whole person feels full of vitality, and the effect is obvious.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (10)
1. The traditional Chinese medicine hair growing cream is characterized by comprising traditional Chinese medicine dry powder and dispersion liquid for dispersing the traditional Chinese medicine dry powder, wherein the traditional Chinese medicine dry powder is mainly prepared by mixing and drying a traditional Chinese medicine composition and lipid-containing auxiliary materials; the traditional Chinese medicine composition comprises the following components: rhizoma Drynariae, and salt.
2. The traditional Chinese medicine hair growing cream for treating alopecia according to claim 1, which is characterized in that: the traditional Chinese medicine composition also comprises one or the combination of more than two of the following components: radix Saposhnikoviae, folium Mori, fructus Vitics Simplicifoliae, folium Pini and cimicifugae rhizoma.
3. The traditional Chinese medicine hair growing cream for treating alopecia according to claim 1, wherein the traditional Chinese medicine composition comprises the following components in parts by weight: 1-20 parts of rhizoma drynariae, 1-20 parts of salt, 1-20 parts of divaricate saposhnikovia root, 1-10 parts of mulberry leaf, 1-20 parts of fructus viticis, 1-10 parts of pine needle and 1-10 parts of cimicifugae foetidae.
4. The traditional Chinese medicine hair growing cream for treating alopecia according to claim 3, which is characterized in that: the auxiliary material also comprises the following components of soybean lecithin and a nonionic surfactant; the auxiliary materials comprise the following components in parts by weight: 1-50 parts of lipid, 1-50 parts of soybean lecithin and 1-50 parts of nonionic surfactant.
5. The traditional Chinese medicine hair growing cream for treating alopecia according to claim 1, which is characterized in that: the dispersion comprises the following components in parts by weight: 0.1-0.5 part of sodium benzoate, 0.5-2 parts of EDTA tetrasodium, 10-20 parts of glycerin, 10-20 parts of sodium hyaluronate, 20-40 parts of horse fat, 10-20 parts of silk hydrolysate and 0.1-1 part of citric acid.
6. The preparation method of the traditional Chinese medicine hair growing cream for treating alopecia according to any one of claims 1 to 5, which comprises the following steps:
s1: preparing Chinese medicinal dry powder, micronizing each component of the Chinese medicinal composition into powder, mixing to obtain Chinese medicinal powder, adding oil, soybean lecithin and nonionic surfactant to obtain suspension, and drying to obtain Chinese medicinal dry powder;
s2: preparing a dispersion liquid, namely dissolving all components prepared into the dispersion liquid in water, and homogenizing to obtain the dispersion liquid;
s3: and (3) uniformly stirring the traditional Chinese medicine dry powder in the step (S1) and the dispersion liquid in the step (S2), and concentrating to obtain the traditional Chinese medicine hair growing cream.
7. The preparation method of the traditional Chinese medicine hair growing cream for treating alopecia according to claim 6, which is characterized by comprising the following steps: in step S1, adding lipid into the Chinese medicinal powder to obtain oil phase; mixing soybean lecithin and nonionic surfactant, and adding water to obtain water phase; adding the oil phase into the water phase, sequentially shearing, performing ultrasonic treatment and homogenizing treatment to obtain suspension, and freeze-drying to obtain Chinese medicinal dry powder.
8. The preparation method of the traditional Chinese medicine hair growing cream for treating alopecia according to claim 7, which is characterized by comprising the following steps: adding lipid into the traditional Chinese medicine powder, and heating to 60-100 ℃ to obtain an oil phase; mixing the soybean lecithin and a nonionic surfactant, adding water, and heating to 60-100 ℃ to obtain a water phase; the shearing is carried out at a high shearing speed: 10000-20000 rpm; the power of ultrasonic treatment is 500-1000W, the frequency is 20-60 kHz, and the treatment time is 1-20 min; the homogenizing time is 1-10 min; pre-freezing the suspension at-15 to 0 ℃ for 1 to 10 hours, and then freeze-drying the suspension at-40 to-80 ℃ for 12 to 24 hours to obtain the traditional Chinese medicine dry powder.
9. The preparation method of the traditional Chinese medicine hair growing cream for treating alopecia according to claim 7, which is characterized by comprising the following steps: in step S1, the lipid is glyceryl tristearate and the nonionic surfactant is poloxamer 188.
10. The preparation method of the traditional Chinese medicine hair growing cream for treating alopecia according to claim 6, which is characterized by comprising the following steps: in step S3, the rotation speed of the homogenizing and stirring is 10-100 rpm, and the time is 10-60 min; the concentration temperature is 20-60 ℃, and the time is 1-5 h.
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